Originally published in 1935, this volume contains the text of the fifth Horsley Memorial Lecture, delivered by Sir Walter Langdon-Brown. This book will be of value to anyone with an interest in medical history, particularly the history of the discovery of the endocrine system.

In this sweeping exploration of the relatively recent obesity epidemic, Michael L. Power and Jay Schulkin probe evolutionary biology, history, physiology, and medical science to uncover the causes of our growing girth. The unexpected answer? Our own evolutionary success. For most of the past few million years, our evolutionary ancestors' survival depended on being able to consume as much as possible when food was available and to store the excess energy for periods when it was scarce. In the developed world today, high-calorie foods are readily obtainable, yet the propensity to store fat is part of our species' heritage, leaving an increasing number of the world's people vulnerable to obesity. In an environment of abundant food, we are anatomically, physiologically, metabolically, and behaviorally programmed in a way that makes it difficult for us to avoid gaining weight. Power and Schulkin's engagingly argued book draws on popular examples and sound science to explain our expanding waistlines and to discuss the consequences of being overweight for different demographic groups. They review the various studies of human and animal fat use and storage, including those that examine fat deposition and metabolism in men and women; chronicle cultural differences in food procurement, preparation, and consumption; and consider the influence of sedentary occupations and lifestyles. A compelling and comprehensive examination of the causes and consequences of the obesity epidemic, "The Evolution of Obesity" offers fascinating insights into the question, Why are we getting fatter?

Despite advances in the diagnosis and treatment of osteoporosis in the last ten years, the condition still poses major clinical challenges. Non-adherence to drug therapy is a widespread problem in patients with rheumatic diseases and osteoporosis in particular.
Part of the Oxford Rheumatology Library, this second edition summarizes the latest developments in the management of osteoporosis and includes new chapters covering the clinical role of denosumab and orthopaedic issues in the management of fractures in patients with osteoporosis. This practical pocketbook is an essential resource for trainees and clinicians in rheumatology, endocrinology, and geriatric medicine, as well as general practitioners and paramedical staff involved in osteoporosis care.

Osteoporosis is a common, underdiagnosed, and undertreated condition, complicated by fractures which lead to significant mortality and morbidity. The prevalence of osteoporotic fractures in postmenopausal women exceeds the combined prevalence of breast cancer, stroke, heart failure, and myocardial infarction. Often called "the silent disease," it does not reveal itself with obvious symptoms until a fracture occurs. In the first year after sustaining a hip fracture, mortality is increased by almost 24% in women and is even higher in men. About half of those who sustain an osteoporotic hip fracture become so disabled that they are no longer able to resume their daily activities, and as many as 20% require long-term institutional care. Effective treatments for osteoporosis are now available if it is diagnosed and addressed in a timely manner. Unfortunately, this disease remains shockingly underdiagnosed and undertreated, even in patients who sustain low-trauma hip fractures.
The past two decades have witnessed radical changes in the diagnosis and management of osteoporosis. The densitometric diagnosis of osteoporosis is noninvasive, quick, and relatively simple. Tools are now available to predict the patient's probability of sustaining fractures, to identify patients who are particularly vulnerable, and to determine which patients will benefit from further investigation and treatment. Various associations have developed guidelines to help clinicians reach a diagnosis and initiate treatment. Due to better understanding of the basic pathophysiology of bone turnover, potent and relatively safe medications that significantly reduce the risk of fractures are now widely available. It is of paramount importance that this disease be diagnosed and treated as early as possible in order to take advantage of these developments and reduce the enormous socioeconomic and psychological impact of osteoporosis.
Given the burden of osteoporotic fractures, all clinicians should have a working knowledge of e diagnosis, treatment, and prevention of the disease. Clinicians should feel comfortable diagnosing and initiating treatment for the majority of patients with osteoporosis. Only complicated cases or patients who are unresponsive to treatment should be referred to specialists. The aim of this book is to distill the available information on osteoporosis into an easily comprehensible format that will serve as a practical guide for busy clinicians. Numerous boxes, tables, diagrams, and figures present the information in an accessible manner. This book will be of particular use to general practitioners, endocrinologists, rheumatologists, gynecologists, internists, geriatricians, and orthopedic surgeons.

Effectively manage parathyroid and bone metabolism disorders with "The Parathyroid Gland and Bone Metabolism! "Brought to you by the same leading endocrinologists responsible for the highly acclaimed two-volume textbook, "Endocrinology: Adult and Pediatric, " this derivative book presents a compilation of chapters covering all endocrinology material related to parathyroid and bone metabolism. Never before available as a stand-alone offering, this content will enable you to give your patients the benefit of today's best know-how on parathyroid and bone metabolism from the leading resource in endocrinology.

 Endocrinology - as only "HARRISON'S" can cover it

A Doody's Core Title for 2015.

Featuring a superb compilation of chapters on endocrinology that appear in "Harrison's Principles of Internal Medicine, Eighteenth Edition," this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined "Harrison's." You will find content from renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation.

Features An organization that reflects the physiologic roots of endocrinology: Pituitary, Thyroid, and Adrenal Disorders; Reproductive Endocrinology; Diabetes Mellitus, Obesity, Lipoprotein Metabolism; Disorders Affecting Multiple Endocrine Systems; and Disorders of Bone and Calcium Metabolism An important introduction that uses numerous examples of translational research to link genetics, cell biology, and physiology with pathophysiology and treatment Integration of pathophysiology with clinical management 108 high-yield questions and answers drawn from "Harrison's Principles of Internal Medicine Self-Assessment and Board Review, 18e" Updates and new developments since the publication of "Harrison's Principles of Internal Medicine, 18e" 29 chapters written by physicians who are recognized experts in the field of endocrinology Helpful appendix of laboratory values of clinical importance

Meet the growing challenges of diabetes and obesity management with "Diabetes Mellitus and Obesity," a compilation of chapters from the highly acclaimed two-volume textbook, "Endocrinology: Adult and Pediatric." Never before available as a stand-alone offering, this derivative book will enable you to put today's best endocrinology practices in diabetes and obesity management to work for your patients.

 At the dawn of precision medicine, there is a new opportunity for novel approaches to understand, diagnose and treat endometrial disorders that affect fertility, reproductive outcomes, and women’s health more broadly. Herein, the editors have assembled critically evaluated state-of-the-art chapters presenting basic and clinical knowledge about the human endometrium that impacts or will impact clinical practice. All clinicians and researchers in Reproductive Medicine will find this book useful as a reference and a valuable tool for continued advancement in the understanding and management of the "endometrial factor".

Imaging in Endocrinology will provide endocrinologists and radiologists of all levels with an outstanding diagnostic imaging atlas to aid them in the diagnosis and management of all the major endocrine diseases they are likely to encounter. In full colour throughout, the 300 high–quality images consist of CT scans, MRI, NMR and histopathology slides, and are arranged by each specific endocrine condition, resulting in a visually outstanding and easily accessible tool that guides the user through exactly what to look out for and provides a practical and extremely useful aid in helping them formulate a diagnosis.

Every major endocrine condition is covered in a specific section, including diseases of the thyroid, pituitary, reproductive and adrenal glands, the pancreas, bone metabolism problems, and the various forms of endocrine cancers. Each disease covered will offer a comparison of the normal findings so as to further assist in diagnosis.
An accompanying website contains an online slide–atlas of all the figures in the book, to allow users to download all figures for use in presentations. Led by Paolo Pozzilli, an internationally–recognised expert in this field, the authors have assembled a wonderful collection of images that will be greatly valued by endocrinologists and radiologists alike, ensuring this is the perfect tool to consult when assessing patients with endocrine disease.

This timely and clinically oriented book uniquely addresses the entire spectrum of treatment for severe obesity and diabetes. It thoroughly examines all aspects from robotic surgery to cell therapy, from the latest antidiabetic drugs to endoscopic procedures and devices, from appetite-inhibiting signals and nutrients to gastric arterial embolization. It offers objective and authoritative information for practicing professionals; not only are successful interventions discussed and updated, but cutting-edge and experimental pathways are also anticipated.

Obesity is the foremost nutritional challenge worldwide. Its companion is type-2 diabetes, the most prevalent metabolic disease. Together they represent the diabesity epidemic, which is draining resources, overwhelming healthcare facilities, and impacting life expectancy and quality of life everywhere. No country has been spared, and most medical specialties have been affected. Many books focus on the surgical options for obesity and diabetes, namely bariatric and metabolic operations. Information on the clinical and pharmacological treatment is also available, conveyed by standard texts on internal medicine and endocrinology. Yet endoscopic maneuvers and prostheses, cell therapy for diabetes, and other innovative approaches are hard to come by, as conventional texts overlook such therapies. This timely publication bridges the gaps between all different therapeutic options, also covering advances in the conservative, surgical and parasurgical domains.

This book will appeal to seasoned specialists, students and healthcare professionals in training alike.

For more than 65 years, Williams Textbook of Endocrinology has been the gold standard in the field, delivering authoritative guidance on every aspect of adult and pediatric endocrine system disorders. The 13th Edition has been thoroughly updated by Drs. Shlomo Melmed, Kenneth S. Polonsky, P. Reed Larsen, and Henry M. Kronenberg, to bring you state-of-the-art coverage of diabetes, metabolic syndrome, obesity, thyroid disease, testicular disorders, and much more, all designed to help you provide optimal care to every patient. Bridging the gap between basic science and clinical information, it is an essential, relevant resource for endocrinologists, endocrine surgeons, gynecologists, internists, and pediatricians - any clinician who needs the most reliable coverage available on the diverse features across the spectrum of endocrine disease.

Management of Prader-Willi Syndrome brings together the contributions of professionals with considerable expertise in diagnosis and management of PWS. Clinical, social, family, and community issues are explored and management strategies identified. The text presents historical, medical, and genetic information to orient the reader. The major portion deals with pragmatic guidelines, rather than research and diagnosis, and is directed to health and educational specialists in academic, clinical, and community settings. This manual is endorsed by The Prader-Willi Syndrome Association, which is recognized world-wide.

The acclaimed clinical guide to managing both pediatric endocrine disorders and inborn errors of metabolism

No other text so skillfully blends the disciplines of endocrinology and inborn metabolic disorders into one clinically focused, highly visual resource as Pediatric Endocrinology and Inborn Errors of Metabolism.

In this practical, user-friendly tutorial, a team of international contributors delivers the latest information and clinical insights clinicians need to confidently diagnose and manage pediatric patients. This full-color resource guides readers through the etiology, pathophysiology, presenting signs and symptoms, diagnostic laboratory examinations, and treatments regimens of each disorder. Pediatric Endocrinology and Inborn Errors of Metabolism successfully balances authority and comprehensiveness with a strong clinical, practical approach that delivers an unmatched integrated discussion of the fields.

• Full-color presentation with numerous photos, illustrations, diagnostic algorithms, tables, and text boxes that summarize key concepts and assist in the decision-making process

• At-a-Glance feature beginning each disease-based chapter summarizes all the clinical information you need to differentiate between disorder sub-types in one easy-to-find place 

• Complete and detailed information on all laboratory and radiographic testing used to diagnose disorders in both disciplines

An up-to-date reference for managing thyroid and parathyroid diseases

 A highly illustrated, detailed and didactic text on medical and surgical aspects of thyroid and parathyroid diseases. -- Pediatric Endocrinology Reviews

The book is well illustrated...and serves as an up-to-date and comprehensive guide to the evaluation and treatment of those with thyroid and parathyroid disorders. It is well resourced and written with insight, and includes the newer surgical techniques, such as minimally invasive surgery and robotics. -- Journal of Laryngology & Otology

...an excellent foundation for understanding all aspects of thyroid and parathyroid disease. -- Head & Neck

Thyroid and Parathyroid Diseases, Second Edition, has been revised and updated to reflect recent advances in the medical and surgical management of thyroid and parathyroid diseases. This new edition serves as both a comprehensive guide to patient evaluation as well as an atlas of advanced surgical techniques for managing patients needing operative intervention. Separate chapters are devoted to minimally invasive techniques and remote access/robotic thyroidectomy techniques, both of which have enjoyed increased application throughout the world.

New in the second edition:

·         A section on state-of-the-art, evidence-based management of challenging parathyroid conditions such as multiple endocrine neoplasia and renal hyperparathyroidism

·         A more detailed discussion of thyroid cancer evaluation and staging

·         A new chapter dedicated to parathyroid cancer

·         Nearly 200 additional full-color illustrations

This new edition is a valuable resource for all surgeons, endocrinologists, and residents seeking to expand their knowledge of thyroid and parathyroid diseases, as well as seasoned clinicians who want to improve patient care and incorporate the latest surgical advancements into their practice.

The WHO Classification of Tumours of Endocrine Organs is the 10th volume in the 4th Edition of the WHO series on histological and genetic typing of human tumours. This authoritative, concise reference provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies evaluating response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, epidemiology, clinical features, pathology, genetics, prognosis, and predictive factors. The book, prepared by 166 authors from 25 countries, contains more than 700 color images and tables and more than 3100 references.

 The Essential Guide to Recognizing and Treating Acute Endocrine and Metabolic Illness

Endocrinology covers some of the most common conditions and serious public health challenges facing medicine today, and endocrine and metabolic emergencies constitute a large proportion of the clinical workload. Endocrine and Metabolic Medical Emergencies: A Clinician’s Guide provides a singular reference to help endocrinologists, acute and general medicine clinicians, hospitalists and critical care physicians, and general practitioners recognize the symptoms of endocrine emergencies and provide the highest standards of care. Already the definitive and most comprehensive guide to endocrine emergency care, this new second edition: provides acute care guidance for a range of both common and unusual endocrine emergencies; details the effects of acute medical and critical illness on metabolic and endocrine systems, and their impacts on endocrine investigations; discusses special patient populations, including the impacts of aging, pregnancy, transplantation, late-effects, perioperative, inherited metabolic disorders and HIV/AIDS on presentation and management; and features detailed coverage of disorders by system, as well as, metabolic bone diseases, neuroendocrine tumors, and more.

Packed with case studies, images, and chapters written by distinguished authors, this guide is designed for both quick reference and study. Coverage includes the presentation, diagnosis, management, and treatment of endocrine and metabolic disorders in an acute care setting, as well as the most up-to-date guidance on issues including clinical lipidology, glucose, sodium, calcium and phosphate, and more.

Features:
• Provides a cutting-edge, problem-orientated approach to the management of clinical problems in endocrinology
• Presents complete updates of existing chapters and new research data, diagnostic techniques, treatment options, and safety concerns
• Discusses neuroendocrine disease and examines strides made by the identification of aryl hydrocarbon receptor–interacting protein mutations
• Reviews changes in diagnostic imaging
• Explores the rapidly increasing incidence of neuroendocrine tumors and their management
• Reviews the endocrinology of aging
• Includes protocols for pituitary function testing

Summary:
Endocrinology is a complex specialty that spans a wide range of diseases, disorders, and conditions. The field is now moving toward an increasingly personalized approach to patient management, with a greater focus on mechanisms of disease and biomarkers. Written by internationally renowned specialists, the second edition of Endocrinology in Clinical Practice provides a cutting-edge, problem-orientated approach to the management of clinical problems in endocrinology.
Highlights of the new edition include:
• An overview of neuroendocrine disease
• Strides made by the identification of aryl hydrocarbon receptor–interacting protein mutations in patients with familial isolated pituitary adenomas
• The diverse roles of IGF-I
• Changes in diagnostic imaging and the increasing use of positron emission tomography
• The rapidly increasing incidence of neuroendocrine tumors and their management
• Hereditary primary hyperparathyroidism and multiple endocrine neoplasia
• Mechanistic and genomic advances related to disorders of calcium regulation and infertility
• The endocrinology of aging
• Protocols for pituitary function testing With complete updates to existing chapters, the second edition also presents new research data, diagnostic techniques, treatment options, and safety concerns related to existing therapies. This edition offers current guidance and scientifically focused information relevant to a range of clinical problems, making it an essential reference for practicing endocrinologists and specialist clinicians.

• First textbook to be devoted entirely to hypoparathyroidism
• Provides essential, up-to-date information on the pathology, diagnosis, and treatment of hypoparathyroidism 
• Covers a wide range of hypoparathyroid disorders Discusses novel replacement therapy with PTH 1-34 and 1-84 
• Includes a chapter on surgical hypoparathyroidism

About this book

Hypoparathyroidism, a condition in which insufficient parathyroid hormone (PTH) is produced to maintain normocalcemia is associated with a variety of acute and chronic symptoms and complications due to hypocalcemia. Replacement therapy utilizing PTH has long been awaited, and this book is new and very timely as it coincides with the  publication of results on the role of the PTH molecule in the pharmacological management of this disorder. This advance is sparking renewed interest in hypoparathyroidism, which is attributable to neck surgery in most cases and to inherited disorders in a minority.

Hypoparathyroidism has been written by acknowledged experts in the field and provides essential, up-to-date information on the pathology, diagnosis, and treatment of the condition. It opens by addressing in detail the anatomy and physiology of the parathyroids and describing the epidemiology and clinical presentation of hypoparathyroidism. The full range of hypoparathyroid disorders are then discussed, including the various genetic forms, postoperative hypoparathyroidism, and other forms of acquired hypoparathyroidism. Individual chapters focus on refractory disease, the impact of the condition on bone, and the management of acute hypocalcemia. Both conventional treatment for hypoparathyroidism and the novel replacement therapy with PTH  peptides are then thoroughly examined. Pseudohypoparathyroidism is also extensively discussed, with information on the various forms, differential diagnosis, and genetic testing. This book will be of interest to all endocrinologists, and also to surgeons and internal medicine physicians.

Table of contents (38 chapters)

·         The History: From Ivar Sandström to the Sequence of Parathyroid Hormone

Mannstadt, Michael (et al.)

Pages 3-10

·         Embryology of the Parathyroid Glands

Manley, Nancy R.

Pages 11-18

·         PTH and PTH-Related Peptides

Isaia, Giancarlo (et al.)

Pages 19-24

·         PTH Assays and Their Clinical Significance

D’Amour, Pierre

Pages 25-32

·         Control of Parathyroid Hormone Secretion by Extracellular Ca

Brown, Edward M.

Pages 33-48

·         Phosphate Control of PTH Secretion

Messa, Piergiorgio

Pages 49-59

·         Role of Magnesium in Parathyroid Physiology

Steen, Oren (et al.)

Pages 61-67

·         The PTH/Vitamin D/FGF23 Axis

Goltzman, David (et al.)

Pages 69-79

·         The PTH Receptorsome and Transduction Pathways

Gardella, Thomas J.

Pages 81-87

·         G Protein Gsα and

Bastepe, Murat

Pages 89-98

·         Parathyroid Hormone Actions on Bone and Kidney

Pajevic, Paola Divieti (et al.)

Pages 99-109

·         PTH and PTHrP: Nonclassical Targets

Cianferotti, Luisella

Pages 111-126

·         In Vitro Cellular Models of Parathyroid Cells

Gomez, Ana Rita (et al.)

Pages 127-135

·         Epidemiology of Hypoparathyroidism

Clarke, Bart L.

Pages 139-154

·         Clinical Presentation of Hypoparathyroidism

Wheeler, Amber L. (et al.)

Pages 155-165

·         Familial Isolated Hypoparathyroidism

Hendy, Geoffrey N. (et al.)

Pages 167-175

·         Autoimmune Hypoparathyroidism

Kemp, E. Helen (et al.)

Pages 177-188

·         DiGeorge Syndrome

Tarsitano, Marina (et al.)

Pages 189-197

·         Hypoparathyroidism, Deafness, and Renal Anomaly Syndrome

Nesbit, M. Andrew

Pages 199-213

·         Hypoparathyroidism, Dwarfism, Medullary Stenosis of Long Bones, and Eye Abnormalities (Kenny-Caffey Syndrome) and Hypoparathyroidism, Retardation, and Dysmorphism (Sanjad-Sakati) Syndrome

Hershkovitz, Eli (et al.)

Pages 215-224

·         Hypoparathyroidism in Mitochondrial Disorders

Orsucci, Daniele (et al.)

Pages 225-230

·         Postoperative Hypoparathyroidism

Tonelli, Francesco (et al.)

Pages 231-247

·         Hypoparathyroidism During Pregnancy, Lactation, and Fetal/Neonatal Development

Kovacs, Christopher S.

Pages 249-269

·         Rare Causes of Acquired Hypoparathyroidism

Wémeau, Jean-Louis

Pages 271-278

·         Refractory Hypoparathyroidism

Masi, Laura

Pages 279-286

·         Bone Histomorphometry in Hypoparathyroidism

Dempster, David W.

Pages 287-296

·         Management of Acute Hypocalcemia

Cooper, Mark Stuart (et al.)

Pages 297-301

·         Conventional Treatment of Chronic Hypoparathyroidism

Rejnmark, Lars

Pages 303-312

·         Follow-up in Chronic Hypoparathyroidism

Mannstadt, Michael (et al.)

Pages 313-318

·         Treatment of Hypoparathyroidism with Parathyroid Hormone 1–34

Winer, Karen K. (et al.)

Pages 319-331

·         Replacement Therapy with PTH(1–84)

Rubin, Mishaela R. (et al.)

Pages 333-342

·         Classification of Pseudohypoparathyroidism and Differential Diagnosis

Mantovani, Giovanna (et al.)

Pages 345-354

·         Pseudohypoparathyroidism Type 1a, Pseudopseudohypoparathyroidism, and Albright Hereditary Osteodystrophy

Weinstein, Lee S.

Pages 355-362

·         Pseudohypoparathyroidism Type Ib (PHP-Ib): PTH-Resistant Hypocalcemia and Hyperphosphatemia Due to Abnormal

Jüppner, Harald

Pages 363-372

·         Genetic Testing in Pseudohypoparathyroidism

Linglart, Agnès (et al.)

Pages 373-388

·         Blomstrand’s Chondrodysplasia

Giusti, Francesca (et al.)

Pages 389-395

·         Hypoparathyroidism During Magnesium Deficiency or Excess

Rizzoli, René

Pages 397-403

·         Advocacy and Hypoparathyroidism in the Twenty-First Century

Sanders, James E. (et al.)

Pages 407-414

This book brings together recognized experts in the field to describe their current techniques for the surgical treatment of diseased thyroid, parathyroid, and adrenal glands, as well as neuroendocrine tumors of small bowel, pancreas, liver, and skin. For each procedure, indications, operative steps, potential pitfalls and complications, and postoperative management are presented. The clear descriptions coupled with informative and beautiful illustrations will give the reader new perspectives and insights into the anatomy and conduct of these procedures. Endocrine surgery has been an area of special interest to surgeons for well over a century, while the increasing incidence of neuroendocrine tumors has more recently led to greater attention to these neoplasms. Significant advances have been made in a variety of areas, the most recent being the introduction of minimally invasive methods of removing diseased glands, and the improved understanding of the natural history of neuroendocrine tumors.

Yen Jaffe's Reproductive Endocrinology helps you successfully diagnose and manage the spectrum of female and male reproductive system diseases, from impaired fertility, infertility, and recurrent pregnancy loss through problems of sexual development, puberty, menstrual disturbances, fibroids, endometriosis, and reproductive aging. This trusted endocrinology reference book is ideal for fellows, endocrinologists, or as a quick reference when making daily diagnostic and therapeutic decisions. It is just the resource you need to offer your patients the best possible reproductive care. "This new edition helps the reader to stay on top of recent developments. It is a must for subspecialists in reproductive medicine and a valuable source of information in the library of any department and clinical unit involved in reproductive medicine." Reviewed by Acta Obstetricia et Gynecologica Scandinavica February 2015 "It is a must for subspecialists in reproductive medicine and a valuable source of information in the library of any department and clinical unit involved in reproductive medicine." Reviewed by Acta Obstetricia et Gynecologica Scandinavica , March 2015

The field of microbial endocrinology is expressly devoted to understanding the mechanisms by which the microbiota (bacteria within the microbiome) interact with the host (“us”). This interaction is a two-way street and the driving force that governs these interactions are the neuroendocrine products of both the host and the microbiota. Chapters include neuroendocrine hormone-induced changes in gene expression and microbial endocrinology and probiotics. This is the first in a series of books dedicated to understanding how bi-directional communication between host and bacteria represents the cutting edge of translational medical research, and hopefully identifies new ways to understand the mechanisms that determine health and disease.​

 The second edition of Endocrine Surgery is a comprehensive update of the previous edition published in 2003. Edited by three leading authorities in the field of surgical endocrinology, the book encompasses the clinical, imaging, nuclear, molecular, technological and evidence-based principles that are applied in the diagnosis and treatment of all categories of endocrine tumors. Authored by experts from across the globe, this textbook reflects the best international clinical practice and also provides an outstanding educational resource.

With full color illustrations throughout, the new edition emphasizes contemporary approaches in successive stages including: pituitary endocrine tumors; pathology and pathophysiology of pulmonary neuroendocrine cells; surgery of endocrine tumors of the lungs and thymus; robotic endocrine surgery; molecular testing of thyroid nodules; pediatric surgery for neuroblastoma and ganglioneuroma; multiple endocrine neoplasia; retroperitoneoscopic adrenalectomy; radionuclide imaging of carcinoid tumors, pancreas and adrenals; serotonin-induced cardiac valvular disease and surgical treatment; multimodal management of primary and metastatic neuroendocrine tumors; pathophysiology and surgery of Type II diabetes; post-bariatric surgery hyperinsulinemic hypoglycemia; and surgical management of metabolic syndrome.

Endocrine Surgery 2e provides the clinician with a definitive resource to reach curative outcomes in the treatment of patients with endocrine pituitary, thyroid, and parathyroid entities. Further coverage of broncho-pulmonary, adrenal, pancreatic, and intestinal neoplasia is also included, making this the definitive textbook on the subject.

Demetrius Pertsemlidis, MD FACS The Bradley H. Jack Professor of Surgery, Icahn School of Medicine at Mount Sinai, New York, USA

William B. Inabnet III, MD FACS Professor of Surgery and Chief, Division of Metabolic, Endocrine and Minimally Invasive Surgery, Icahn School of Medicine at Mount Sinai, New York, USA

Michel Gagner, M.D. FRCSC, FACS, FASMBS

Clinical Professor of surgery, Herbert Wertheim School of Medicine, Florida International 

This much-anticipated book presents the procedural phases required to achieve optimal results in the esthetic rehabilitation of patients in need of fixed prostheses. Communication between the clinician and the technician, which is essential to the aesthetic, biologic, and functional integration of the prosthetic rehabilitation, is highlighted through a step-by-step presentation of all clinical and laboratory procedures. Chapters demonstrate methods to obtain accurate facebow recordings, impression materials and techniques, fabrication of provisional restorations, and incorporation of interdisciplinary therapies for ideal comfort and aesthetics. All this information is transferred to the final restorations, which should provide patients with long-term prosthetic solutions exhibiting appropriate fit, form, and function. Hundreds of full-colour clinical photographs and detailed illustrations accompany each treatment phase and situation. This beautiful book picks up where Volume 1 ended and delivers its message with equal clarity and precision.

This book presents an overview of the research advances and clinical challenges of the pineal gland. The topics analysed cover a broad spectrum of functions played by the pineal gland and present new information in this area of research. These topics include: the physiology and pathology of skeletal and cardiac muscles; the beneficial actions of melatonin; n3 and n6 essential fatty acids, lipoxygenation and melatonin synthesis; the structure and functions of the fish pineal organ; therapeutical aspects of melatonin in bone marrow and thyroid-associated immune regulation; melatonin as a promising cytoprotective agent against ischemia-reperfusion injury in the liver; therapeutic approaches with melatonin; melatonin and neuroinflammation: encouraging findings vs. fundamental problems; melatonin and aging; pineal parenchymal tumor of intermediate differentiation; pineal glial cysts: features and clinical significance; melatonin as a modulator of radiosensibility and chemosensibility in cancer, circadian rhythm and melatonin associated with cancer development and treatment.

Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 % continuing to make osteoporosis a hot topic in medicine.

 A much-needed comprehensive resource, Endocrine Pathology covers clinical, radiologic, biochemical, molecular, cytogenetic, immunologic and histopathologic aspects of endocrine disorders, including the full spectrum of both neoplastic and non-neoplastic lesions. The first section of the book provides an overview of the clinical presentations of endocrine diseases, while the second section reviews the wide variety of investigative techniques used in their diagnosis. The third and largest section provides a comprehensive tissue- and organ-based approach to the diagnosis of endocrine disorders, including morphologic, genetic and proteomic features with clinicopathologic correlations. All chapters are richly illustrated with numerous color images, tables and algorithms, and the book is packaged with a password, giving the user online access to all text and images. Written and edited by the world's leading experts, this comprehensive and up-to-date book is the definitive resource on endocrine pathology for all pathologists, endocrinologists and researchers.

o    Highlights advances in laboratory technology and new concepts in the molecular basis of endocrine diseases, allowing readers to understand and adopt modern approaches to the diagnosis and management of endocrine disorders

o    Integrates numerous illustrations, tables, algorithms, charts and high-quality color images, all of which are available to the reader in both print and electronic formats

o    Provides a definite review of the evolving landscape of endocrine pathology practice, illustrating the role of the pathologist in the multidisciplinary medical team

Table of Contents

List of contributors
Preface
Part I. Clinical Approaches:
1. Clinical presentations of endocrine diseases Karen Gomez Hernandez and Shereen Ezzat
2. Familial endocrine tumor syndromes Charalampos Lyssikatos, Fabio R. Faucz and Constantine A. Stratakis
3. Immunologic basis of endocrine diseases Shawn Winer, Hubert Tsui, and Daniel Winer
Part II. Investigative Techniques:
4. Biochemical testing Paul M. Yip, Karen Gomez-Hernandez, and Shereen Ezzat
5. Radiologic imaging Artur Salmaslioglu, Baris Bakir, M. Gulbiz Dagoglu Kartal, Michael Chan, Juan Pablo Cruz, Walter Kucharczyk, Eugene Yu, and Karen Gulenchyn
6. Cytologic assessment Scott L. Boerner
7. Intraoperative consultations Ozgur Mete and Sylvia L. Asa
8. Morphology and immunohistochemistry Robert Osamura
9. Cytogenetic testing methods Hong Wang and Cuihong Wei
10. Experimental models of endocrine diseases Toru Tateno and Tae Nakano-Tateno
Part III. Anatomical Endocrine Pathology:
11. The brain as an endocrine organ (including the pineal gland) M. Beatriz S. Lopes, Sugoto Mukherjee, Michael A. Reardon, and Carrie A. Mohila
12. The pituitary gland Sylvia L. Asa and Ozgur Mete
13. Thyroid Vania Nosé, Ana Carolina de Jesus, Ozgur Mete, Sylvia L. Asa, Marco Volante, Mauro Papotti and Darcy Kerr
14. Parathyroid gland Lori A. Erickson
15. Adrenal cortex Kai Duan, Thomas J. Giordano and Ozgur Mete
16. Adrenal medulla and extra-adrenal paraganglia Lindsey Oudijk, Ronald R. de Krijger, Karel Pacak, and Arthur S. Tischler
17. Endocrine lesions of the gastrointestinal tract Stefano Serra
18. The endocrine pancreas Stefano Serra, Frediano Inzani and Guido Rindi
19. Liver in endocrine disease Oyedele A. Adeyi and Sandra E. Fischer
20. Pulmonary, thymic and mediastinal neuroendocrine lesions Mauro Papotti, Sylvie Lantuejoul, Giulio Rossi, and Marco Volante
21. The kidney in endocrine disease Clariss Cassol and Carmen Avila-Casado
22. Endocrine aspects of the male genitourinary system Michelle Downes
23. Endocrine lesions in the mammary gland Tadao Nakazawa and Tetsuo Kondo
24. The placenta N. J. Sebire and A. R. Bamber
25. The gynecologic tract – neuroendocrine tumors and ovarian tumors with endocrine association Marjan Rouzbahman and Blaise Clarke
26. Skin manifestations in endocrine diseases Karen A. Naert, Nadya Al-Faraidy, Ayman Al-Habeeb, Danny Ghazarian, Cuyan Demirkesen and Can Baykal
27. Cardiovascular system in endocrine disease Pooja Singhal and Jagdish Butany
28. Soft tissue in endocrine disease Brendan Dickson
29. Bone in endocrine disease Brendan Dickson, David Goltzman and Richard Kremer
30. The approach to metastatic endocrine tumors of unknown primary site Sara Hafezi-Bakthiari and Ozgur Mete
Index.

The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.

• Revises and expands on classic earlier editions, providing a comprehensive text on diabetes mellitus
• Covers all major topics including glucose metabolism, diagnosis and epidemiology, genetics, management and prevention
• Provides a global perspective on diabetes mellitus, diabetic syndromes and related disorders
• Delivers expertise in diabetes research and treatment, edited by a leading figure in the field

About this Reference Work

The third edition of this important work is a timely update to the comprehensive textbook first published in 2002 and reissued in a second edition in 2010. The past few years have witnessed major developments in our understanding of diabetes and in therapeutic approaches to this disease and its numerous complications. Thus, all chapters have been significantly revised and updated with current evidence and best practices, and four brand new chapters are included, discussing the potential role of vitamin D in the pathogenesis of diabetes, peculiarities of diabetes in the elderly, oral manifestations of diabetes, and the current state of bariatric surgery.