Originally published in 1935, this volume contains the text of the fifth Horsley Memorial Lecture, delivered by Sir Walter Langdon-Brown. This book will be of value to anyone with an interest in medical history, particularly the history of the discovery of the endocrine system.

In this sweeping exploration of the relatively recent obesity epidemic, Michael L. Power and Jay Schulkin probe evolutionary biology, history, physiology, and medical science to uncover the causes of our growing girth. The unexpected answer? Our own evolutionary success. For most of the past few million years, our evolutionary ancestors' survival depended on being able to consume as much as possible when food was available and to store the excess energy for periods when it was scarce. In the developed world today, high-calorie foods are readily obtainable, yet the propensity to store fat is part of our species' heritage, leaving an increasing number of the world's people vulnerable to obesity. In an environment of abundant food, we are anatomically, physiologically, metabolically, and behaviorally programmed in a way that makes it difficult for us to avoid gaining weight. Power and Schulkin's engagingly argued book draws on popular examples and sound science to explain our expanding waistlines and to discuss the consequences of being overweight for different demographic groups. They review the various studies of human and animal fat use and storage, including those that examine fat deposition and metabolism in men and women; chronicle cultural differences in food procurement, preparation, and consumption; and consider the influence of sedentary occupations and lifestyles. A compelling and comprehensive examination of the causes and consequences of the obesity epidemic, "The Evolution of Obesity" offers fascinating insights into the question, Why are we getting fatter?

Effectively manage parathyroid and bone metabolism disorders with "The Parathyroid Gland and Bone Metabolism! "Brought to you by the same leading endocrinologists responsible for the highly acclaimed two-volume textbook, "Endocrinology: Adult and Pediatric, " this derivative book presents a compilation of chapters covering all endocrinology material related to parathyroid and bone metabolism. Never before available as a stand-alone offering, this content will enable you to give your patients the benefit of today's best know-how on parathyroid and bone metabolism from the leading resource in endocrinology.

 Endocrinology - as only "HARRISON'S" can cover it

A Doody's Core Title for 2015.

Featuring a superb compilation of chapters on endocrinology that appear in "Harrison's Principles of Internal Medicine, Eighteenth Edition," this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined "Harrison's." You will find content from renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation.

Features An organization that reflects the physiologic roots of endocrinology: Pituitary, Thyroid, and Adrenal Disorders; Reproductive Endocrinology; Diabetes Mellitus, Obesity, Lipoprotein Metabolism; Disorders Affecting Multiple Endocrine Systems; and Disorders of Bone and Calcium Metabolism An important introduction that uses numerous examples of translational research to link genetics, cell biology, and physiology with pathophysiology and treatment Integration of pathophysiology with clinical management 108 high-yield questions and answers drawn from "Harrison's Principles of Internal Medicine Self-Assessment and Board Review, 18e" Updates and new developments since the publication of "Harrison's Principles of Internal Medicine, 18e" 29 chapters written by physicians who are recognized experts in the field of endocrinology Helpful appendix of laboratory values of clinical importance

Meet the growing challenges of diabetes and obesity management with "Diabetes Mellitus and Obesity," a compilation of chapters from the highly acclaimed two-volume textbook, "Endocrinology: Adult and Pediatric." Never before available as a stand-alone offering, this derivative book will enable you to put today's best endocrinology practices in diabetes and obesity management to work for your patients.

For more than 65 years, Williams Textbook of Endocrinology has been the gold standard in the field, delivering authoritative guidance on every aspect of adult and pediatric endocrine system disorders. The 13th Edition has been thoroughly updated by Drs. Shlomo Melmed, Kenneth S. Polonsky, P. Reed Larsen, and Henry M. Kronenberg, to bring you state-of-the-art coverage of diabetes, metabolic syndrome, obesity, thyroid disease, testicular disorders, and much more, all designed to help you provide optimal care to every patient. Bridging the gap between basic science and clinical information, it is an essential, relevant resource for endocrinologists, endocrine surgeons, gynecologists, internists, and pediatricians - any clinician who needs the most reliable coverage available on the diverse features across the spectrum of endocrine disease.

Management of Prader-Willi Syndrome brings together the contributions of professionals with considerable expertise in diagnosis and management of PWS. Clinical, social, family, and community issues are explored and management strategies identified. The text presents historical, medical, and genetic information to orient the reader. The major portion deals with pragmatic guidelines, rather than research and diagnosis, and is directed to health and educational specialists in academic, clinical, and community settings. This manual is endorsed by The Prader-Willi Syndrome Association, which is recognized world-wide.

Features:
• Provides a cutting-edge, problem-orientated approach to the management of clinical problems in endocrinology
• Presents complete updates of existing chapters and new research data, diagnostic techniques, treatment options, and safety concerns
• Discusses neuroendocrine disease and examines strides made by the identification of aryl hydrocarbon receptor–interacting protein mutations
• Reviews changes in diagnostic imaging
• Explores the rapidly increasing incidence of neuroendocrine tumors and their management
• Reviews the endocrinology of aging
• Includes protocols for pituitary function testing

Summary:
Endocrinology is a complex specialty that spans a wide range of diseases, disorders, and conditions. The field is now moving toward an increasingly personalized approach to patient management, with a greater focus on mechanisms of disease and biomarkers. Written by internationally renowned specialists, the second edition of Endocrinology in Clinical Practice provides a cutting-edge, problem-orientated approach to the management of clinical problems in endocrinology.
Highlights of the new edition include:
• An overview of neuroendocrine disease
• Strides made by the identification of aryl hydrocarbon receptor–interacting protein mutations in patients with familial isolated pituitary adenomas
• The diverse roles of IGF-I
• Changes in diagnostic imaging and the increasing use of positron emission tomography
• The rapidly increasing incidence of neuroendocrine tumors and their management
• Hereditary primary hyperparathyroidism and multiple endocrine neoplasia
• Mechanistic and genomic advances related to disorders of calcium regulation and infertility
• The endocrinology of aging
• Protocols for pituitary function testing With complete updates to existing chapters, the second edition also presents new research data, diagnostic techniques, treatment options, and safety concerns related to existing therapies. This edition offers current guidance and scientifically focused information relevant to a range of clinical problems, making it an essential reference for practicing endocrinologists and specialist clinicians.

• First textbook to be devoted entirely to hypoparathyroidism
• Provides essential, up-to-date information on the pathology, diagnosis, and treatment of hypoparathyroidism 
• Covers a wide range of hypoparathyroid disorders Discusses novel replacement therapy with PTH 1-34 and 1-84 
• Includes a chapter on surgical hypoparathyroidism

About this book

Hypoparathyroidism, a condition in which insufficient parathyroid hormone (PTH) is produced to maintain normocalcemia is associated with a variety of acute and chronic symptoms and complications due to hypocalcemia. Replacement therapy utilizing PTH has long been awaited, and this book is new and very timely as it coincides with the  publication of results on the role of the PTH molecule in the pharmacological management of this disorder. This advance is sparking renewed interest in hypoparathyroidism, which is attributable to neck surgery in most cases and to inherited disorders in a minority.

Hypoparathyroidism has been written by acknowledged experts in the field and provides essential, up-to-date information on the pathology, diagnosis, and treatment of the condition. It opens by addressing in detail the anatomy and physiology of the parathyroids and describing the epidemiology and clinical presentation of hypoparathyroidism. The full range of hypoparathyroid disorders are then discussed, including the various genetic forms, postoperative hypoparathyroidism, and other forms of acquired hypoparathyroidism. Individual chapters focus on refractory disease, the impact of the condition on bone, and the management of acute hypocalcemia. Both conventional treatment for hypoparathyroidism and the novel replacement therapy with PTH  peptides are then thoroughly examined. Pseudohypoparathyroidism is also extensively discussed, with information on the various forms, differential diagnosis, and genetic testing. This book will be of interest to all endocrinologists, and also to surgeons and internal medicine physicians.

Table of contents (38 chapters)

·         The History: From Ivar Sandström to the Sequence of Parathyroid Hormone

Mannstadt, Michael (et al.)

Pages 3-10

·         Embryology of the Parathyroid Glands

Manley, Nancy R.

Pages 11-18

·         PTH and PTH-Related Peptides

Isaia, Giancarlo (et al.)

Pages 19-24

·         PTH Assays and Their Clinical Significance

D’Amour, Pierre

Pages 25-32

·         Control of Parathyroid Hormone Secretion by Extracellular Ca

Brown, Edward M.

Pages 33-48

·         Phosphate Control of PTH Secretion

Messa, Piergiorgio

Pages 49-59

·         Role of Magnesium in Parathyroid Physiology

Steen, Oren (et al.)

Pages 61-67

·         The PTH/Vitamin D/FGF23 Axis

Goltzman, David (et al.)

Pages 69-79

·         The PTH Receptorsome and Transduction Pathways

Gardella, Thomas J.

Pages 81-87

·         G Protein Gsα and

Bastepe, Murat

Pages 89-98

·         Parathyroid Hormone Actions on Bone and Kidney

Pajevic, Paola Divieti (et al.)

Pages 99-109

·         PTH and PTHrP: Nonclassical Targets

Cianferotti, Luisella

Pages 111-126

·         In Vitro Cellular Models of Parathyroid Cells

Gomez, Ana Rita (et al.)

Pages 127-135

·         Epidemiology of Hypoparathyroidism

Clarke, Bart L.

Pages 139-154

·         Clinical Presentation of Hypoparathyroidism

Wheeler, Amber L. (et al.)

Pages 155-165

·         Familial Isolated Hypoparathyroidism

Hendy, Geoffrey N. (et al.)

Pages 167-175

·         Autoimmune Hypoparathyroidism

Kemp, E. Helen (et al.)

Pages 177-188

·         DiGeorge Syndrome

Tarsitano, Marina (et al.)

Pages 189-197

·         Hypoparathyroidism, Deafness, and Renal Anomaly Syndrome

Nesbit, M. Andrew

Pages 199-213

·         Hypoparathyroidism, Dwarfism, Medullary Stenosis of Long Bones, and Eye Abnormalities (Kenny-Caffey Syndrome) and Hypoparathyroidism, Retardation, and Dysmorphism (Sanjad-Sakati) Syndrome

Hershkovitz, Eli (et al.)

Pages 215-224

·         Hypoparathyroidism in Mitochondrial Disorders

Orsucci, Daniele (et al.)

Pages 225-230

·         Postoperative Hypoparathyroidism

Tonelli, Francesco (et al.)

Pages 231-247

·         Hypoparathyroidism During Pregnancy, Lactation, and Fetal/Neonatal Development

Kovacs, Christopher S.

Pages 249-269

·         Rare Causes of Acquired Hypoparathyroidism

Wémeau, Jean-Louis

Pages 271-278

·         Refractory Hypoparathyroidism

Masi, Laura

Pages 279-286

·         Bone Histomorphometry in Hypoparathyroidism

Dempster, David W.

Pages 287-296

·         Management of Acute Hypocalcemia

Cooper, Mark Stuart (et al.)

Pages 297-301

·         Conventional Treatment of Chronic Hypoparathyroidism

Rejnmark, Lars

Pages 303-312

·         Follow-up in Chronic Hypoparathyroidism

Mannstadt, Michael (et al.)

Pages 313-318

·         Treatment of Hypoparathyroidism with Parathyroid Hormone 1–34

Winer, Karen K. (et al.)

Pages 319-331

·         Replacement Therapy with PTH(1–84)

Rubin, Mishaela R. (et al.)

Pages 333-342

·         Classification of Pseudohypoparathyroidism and Differential Diagnosis

Mantovani, Giovanna (et al.)

Pages 345-354

·         Pseudohypoparathyroidism Type 1a, Pseudopseudohypoparathyroidism, and Albright Hereditary Osteodystrophy

Weinstein, Lee S.

Pages 355-362

·         Pseudohypoparathyroidism Type Ib (PHP-Ib): PTH-Resistant Hypocalcemia and Hyperphosphatemia Due to Abnormal

Jüppner, Harald

Pages 363-372

·         Genetic Testing in Pseudohypoparathyroidism

Linglart, Agnès (et al.)

Pages 373-388

·         Blomstrand’s Chondrodysplasia

Giusti, Francesca (et al.)

Pages 389-395

·         Hypoparathyroidism During Magnesium Deficiency or Excess

Rizzoli, René

Pages 397-403

·         Advocacy and Hypoparathyroidism in the Twenty-First Century

Sanders, James E. (et al.)

Pages 407-414

Yen Jaffe's Reproductive Endocrinology helps you successfully diagnose and manage the spectrum of female and male reproductive system diseases, from impaired fertility, infertility, and recurrent pregnancy loss through problems of sexual development, puberty, menstrual disturbances, fibroids, endometriosis, and reproductive aging. This trusted endocrinology reference book is ideal for fellows, endocrinologists, or as a quick reference when making daily diagnostic and therapeutic decisions. It is just the resource you need to offer your patients the best possible reproductive care. "This new edition helps the reader to stay on top of recent developments. It is a must for subspecialists in reproductive medicine and a valuable source of information in the library of any department and clinical unit involved in reproductive medicine." Reviewed by Acta Obstetricia et Gynecologica Scandinavica February 2015 "It is a must for subspecialists in reproductive medicine and a valuable source of information in the library of any department and clinical unit involved in reproductive medicine." Reviewed by Acta Obstetricia et Gynecologica Scandinavica , March 2015

This much-anticipated book presents the procedural phases required to achieve optimal results in the esthetic rehabilitation of patients in need of fixed prostheses. Communication between the clinician and the technician, which is essential to the aesthetic, biologic, and functional integration of the prosthetic rehabilitation, is highlighted through a step-by-step presentation of all clinical and laboratory procedures. Chapters demonstrate methods to obtain accurate facebow recordings, impression materials and techniques, fabrication of provisional restorations, and incorporation of interdisciplinary therapies for ideal comfort and aesthetics. All this information is transferred to the final restorations, which should provide patients with long-term prosthetic solutions exhibiting appropriate fit, form, and function. Hundreds of full-colour clinical photographs and detailed illustrations accompany each treatment phase and situation. This beautiful book picks up where Volume 1 ended and delivers its message with equal clarity and precision.

 A much-needed comprehensive resource, Endocrine Pathology covers clinical, radiologic, biochemical, molecular, cytogenetic, immunologic and histopathologic aspects of endocrine disorders, including the full spectrum of both neoplastic and non-neoplastic lesions. The first section of the book provides an overview of the clinical presentations of endocrine diseases, while the second section reviews the wide variety of investigative techniques used in their diagnosis. The third and largest section provides a comprehensive tissue- and organ-based approach to the diagnosis of endocrine disorders, including morphologic, genetic and proteomic features with clinicopathologic correlations. All chapters are richly illustrated with numerous color images, tables and algorithms, and the book is packaged with a password, giving the user online access to all text and images. Written and edited by the world's leading experts, this comprehensive and up-to-date book is the definitive resource on endocrine pathology for all pathologists, endocrinologists and researchers.

o    Highlights advances in laboratory technology and new concepts in the molecular basis of endocrine diseases, allowing readers to understand and adopt modern approaches to the diagnosis and management of endocrine disorders

o    Integrates numerous illustrations, tables, algorithms, charts and high-quality color images, all of which are available to the reader in both print and electronic formats

o    Provides a definite review of the evolving landscape of endocrine pathology practice, illustrating the role of the pathologist in the multidisciplinary medical team

Table of Contents

List of contributors
Preface
Part I. Clinical Approaches:
1. Clinical presentations of endocrine diseases Karen Gomez Hernandez and Shereen Ezzat
2. Familial endocrine tumor syndromes Charalampos Lyssikatos, Fabio R. Faucz and Constantine A. Stratakis
3. Immunologic basis of endocrine diseases Shawn Winer, Hubert Tsui, and Daniel Winer
Part II. Investigative Techniques:
4. Biochemical testing Paul M. Yip, Karen Gomez-Hernandez, and Shereen Ezzat
5. Radiologic imaging Artur Salmaslioglu, Baris Bakir, M. Gulbiz Dagoglu Kartal, Michael Chan, Juan Pablo Cruz, Walter Kucharczyk, Eugene Yu, and Karen Gulenchyn
6. Cytologic assessment Scott L. Boerner
7. Intraoperative consultations Ozgur Mete and Sylvia L. Asa
8. Morphology and immunohistochemistry Robert Osamura
9. Cytogenetic testing methods Hong Wang and Cuihong Wei
10. Experimental models of endocrine diseases Toru Tateno and Tae Nakano-Tateno
Part III. Anatomical Endocrine Pathology:
11. The brain as an endocrine organ (including the pineal gland) M. Beatriz S. Lopes, Sugoto Mukherjee, Michael A. Reardon, and Carrie A. Mohila
12. The pituitary gland Sylvia L. Asa and Ozgur Mete
13. Thyroid Vania Nosé, Ana Carolina de Jesus, Ozgur Mete, Sylvia L. Asa, Marco Volante, Mauro Papotti and Darcy Kerr
14. Parathyroid gland Lori A. Erickson
15. Adrenal cortex Kai Duan, Thomas J. Giordano and Ozgur Mete
16. Adrenal medulla and extra-adrenal paraganglia Lindsey Oudijk, Ronald R. de Krijger, Karel Pacak, and Arthur S. Tischler
17. Endocrine lesions of the gastrointestinal tract Stefano Serra
18. The endocrine pancreas Stefano Serra, Frediano Inzani and Guido Rindi
19. Liver in endocrine disease Oyedele A. Adeyi and Sandra E. Fischer
20. Pulmonary, thymic and mediastinal neuroendocrine lesions Mauro Papotti, Sylvie Lantuejoul, Giulio Rossi, and Marco Volante
21. The kidney in endocrine disease Clariss Cassol and Carmen Avila-Casado
22. Endocrine aspects of the male genitourinary system Michelle Downes
23. Endocrine lesions in the mammary gland Tadao Nakazawa and Tetsuo Kondo
24. The placenta N. J. Sebire and A. R. Bamber
25. The gynecologic tract – neuroendocrine tumors and ovarian tumors with endocrine association Marjan Rouzbahman and Blaise Clarke
26. Skin manifestations in endocrine diseases Karen A. Naert, Nadya Al-Faraidy, Ayman Al-Habeeb, Danny Ghazarian, Cuyan Demirkesen and Can Baykal
27. Cardiovascular system in endocrine disease Pooja Singhal and Jagdish Butany
28. Soft tissue in endocrine disease Brendan Dickson
29. Bone in endocrine disease Brendan Dickson, David Goltzman and Richard Kremer
30. The approach to metastatic endocrine tumors of unknown primary site Sara Hafezi-Bakthiari and Ozgur Mete
Index.

The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.