Pret
Limba
Disponibilitate
-
145.00 lei
In this sweeping exploration of the relatively recent obesity epidemic, Michael L. Power and Jay Schulkin probe evolutionary biology, history, physiology, and medical science to uncover the causes of our growing girth. The unexpected answer? Our own evolutionary success. For most of the past few million years, our evolutionary ancestors' survival depended on being able to consume as much as possible when food was available and to store the excess energy for periods when it was scarce. In the developed world today, high-calorie foods are readily obtainable, yet the propensity to store fat is part of our species' heritage, leaving an increasing number of the world's people vulnerable to obesity. In an environment of abundant food, we are anatomically, physiologically, metabolically, and behaviorally programmed in a way that makes it difficult for us to avoid gaining weight. Power and Schulkin's engagingly argued book draws on popular examples and sound science to explain our expanding waistlines and to discuss the consequences of being overweight for different demographic groups. They review the various studies of human and animal fat use and storage, including those that examine fat deposition and metabolism in men and women; chronicle cultural differences in food procurement, preparation, and consumption; and consider the influence of sedentary occupations and lifestyles. A compelling and comprehensive examination of the causes and consequences of the obesity epidemic, "The Evolution of Obesity" offers fascinating insights into the question, Why are we getting fatter?
-
Endocrinology Adult and Pediatric: The Parathyroid Gland and Bone Metabolism, 6th Edition
by John T PottsLa comanda in aproximativ 4 saptamani18000lei 160.00 leiDescription:
Effectively manage parathyroid and bone metabolism disorders with The Parathyroid Gland and Bone Metabolism! Brought to you by the same leading endocrinologists responsible for the highly acclaimed two-volume textbook, Endocrinology: Adult and Pediatric, this derivative book presents a compilation of chapters covering all endocrinology material related to parathyroid and bone metabolism. Never before available as a stand-alone offering, this content will enable you to give your patients the benefit of today’s best know-how on parathyroid and bone metabolism from the leading resource in endocrinology.
Features:
Stay abreast of the newest knowledge and advances on parathyroid and bone metabolism, including…
pediatric parathyroid disorders and bone metabolism disorders
major diseases common to the aging population such as osteoporosis
advances in the genetics of disorders involving calciotropic hormones
newer diagnostic approaches and therapies for bone diseases, from osteoporosis to Paget's disease
and much more.
Count on all the authority that has made Endocrinology, 6th Edition, edited by Drs. Jameson and De Groot, the go-to clinical medical reference for endocrinologists worldwide.
Make the best clinical decisions with an enhanced emphasis on evidence-based practice in conjunction with expert opinion.
Table Of Contents:
Parathyroid Hormone and Parathyroid Hormone-Related Peptide in the Regulation of Calcium Homeostasis and Bone Development
Calcitonin
Vitamin D: From Photosynthesis, Metabolism, and Action to Clinical Applications
Bone Development and Remodeling
Calcium Regulation, Calcium Homeostasis, and Genetic Disorders of Calcium Metabolism
Genetic Disorders of Phosphate Homeostasis
Primary Hyperparathyroidism
Malignancy-Associated Hypercalcemia and Medical Management
Surgical Management of Hyperparathyroidism
Pseudohypoparathyroidism, Albright’s Hereditary Osteodystrophy, and Progressive Osseus Heteroplasia: Disorders Caused by Inactivating GNAS Mutations
Genetic Defects in Vitamin D Metabolism and Action
Hereditary Disorders of the Skeleton
Bone Density and Imaging of Osteoporosis
Chronic Kidney Disease Mineral and Bone Disorder
Disorders of Calcification: Osteomalacia and Rickets
Paget’s Disease of Bone
Bottom of Form
-
165.00 lei
The book is in question and answer format, very easy and comfortable to read. It incorporates objective structures practical examination (OSPE) and other format on Endocrinology questions. Contents of the book have been updated as per the latest guidelines by various endocrine organizations all over the world, especially American Association of Clinical Endocrinology (AACE) guidelines, American Diabetes Association (ADA), European Association for the Study of Diabetes (EASD), American Thyroid Association (ATA) guidelines, and other organizations of the world.
-
Clinical Endocrinology and Diabetes at a Glance
La comanda in aproximativ 4 saptamani175.00 leiDescription:
Recognising a need to promote and enhance teaching of clinical endocrinology and diabetes in UK medical schools, the Society for Endocrinology, in collaboration with Diabetes UK and the Association of British Clinical Diabetologists, created a national curriculum that sets out the minimum recommended standards for undergraduate medical education.
Clinical Endocrinology and Diabetes at a Glance corresponds to the curriculum and covers all important areas of diabetes and endocrinology in a clinically relevant and concise manner, with complementary figures to ensure principles are explained clearly. It highlights key practical skills for undergraduates in line with the GMC recommendations that medical graduates should be well prepared for their Foundation posts. There is also emphasis on the importance of multidisciplinary teams in the management of endocrine diseases and diabetes. These include sections on structured education programmes, psychosocial aspects, and patient self-management and monitoring.
Clinical Endocrinology and Diabetes at a Glance will serve as a valuable resource for medical students and junior doctors treating patients with these conditions.
Table of Contents:
Part 1: Introduction
1: Introduction to endocrinology
Synthesis, release and transport
Mechanisms of hormone action
Control and feedback
Patterns of hormone secretion
Measurement of hormones
Dynamic endocrine tests
Part 2: Disorders of the hypothalamic–pituitary axis
2: The hypothalamic–pituitary axis and its assessment
Physiology
Assessment of the pituitary gland
Imaging
3: Acromegaly
Clinical features
Investigation
Management
4: Cushing’s syndrome
Clinical features
Investigation
Differential diagnosis
Management
Follow-up and monitoring
5: Hypopituitarism and non-functioning pituitary adenomas
Non-functioning pituitary adenomas
Hypopituitarism
6: Prolactinoma and hyperprolactinaemia
Hyperprolactinaemia
Prolactinoma
Pituitary incidentaloma
Part 3: Disorders of thirst and fluid balance
7: Hypernatraemia and diabetes insipidus
Posterior pituitary function and sodium homeostasis
Hypernatraemia
Diabetes insipidus
Acute severe hypernatraemia
8: Hyponatraemia and SIADH
Hyponatraemia
Syndrome of inappropriate ADH
Acute severe hyponatraemia
Part 4: Thyroid disorders
9: Thyroid function
Anatomy
Physiology
Actions of thyroid hormones
Interpreting thyroid function tests
Primary and secondary hypothyroidism
Hyperthyroidism
Factors affecting thyroid results
10: Hyperthyroidism: clinical presentation and investigation
Causes
Clinical presentation
Investigation
11: Hyperthyroidism: management and ophthalmopathy
Medical treatment
Definitive treatments
Thyroid ophthalmopathy
12: Hyperthyroidism: special circumstances
Hyperthyroidism and pregnancy
Subclinical hyperthyroidism
Elevated fT4 with unsuppressed TSH
Assay interference
TSHoma and thyroid hormone resistance
13: Hypothyroidism
Causes
Clinical features
Investigations
Treatment
Subclinical hypothyroidism
Hypothyroidism and pregnancy
Polyglandular autoimmune disease
14: Goitre, thyroid nodules and cancer
Goitre
Multinodular goitre
Solitary thyroid nodule
Thyroid cancer
Management of differentiated thyroid cancer
Part 5: Disorders of calcium homeostasis
15: Physiology of calcium, PTH and vitamin D metabolism
Parathyroid hormone
Vitamin D
Vitamin D deficiency
16: Hypercalcaemia
Hypercalcaemia with suppressed PTH
Hypercalcaemia with non-suppressed PTH
Acute severe hypercalcaemia
17: Hypocalcaemia
Causes
Clinical features
Investigation
Treatment
Pseudo-hypoparathyroidism
18: Osteoporosis
Causes
Clinical features
Investigation
Assessing fracture risk
Treatment
Part 6: Disorders of the adrenal gland
19: Steroid physiology and biochemical assessment
Steroid synthesis
Glucocorticoids
Adrenal androgens
Mineralocorticoids
Biochemical assessment of the adrenal axis
20: Adrenal insufficiency
Primary adrenal insufficiency
Secondary adrenal insufficiency
Steroid-induced hypoadrenalism
21: Adrenocortical tumours
Adrenal Cushing’s syndrome
Primary hyperaldosteronism
Adrenal incidentalomas
22: Disorders of the adrenal medulla
Phaeochromocytoma and paraganglioma
Part 7: Disorders of the reproductive system
23: Physiology of the reproductive system
Physiology of female reproduction
Physiology of male reproduction
24: Growth, puberty and sexual differentiation
Normal growth
Normal puberty
Short stature
Precocious puberty
Delayed puberty
Sexual differentiation
Transition of young people into the adult service
25: Menstrual disturbance
Definition
Causes
Assessment
Treatment
Premature ovarian failure
Turner’s syndrome
26: Hyperandrogenism
Hirsutism
Polycystic ovary syndrome
Congenital adrenal hyperplasia
27: Menopause and HRT
Definition
Clinical presentation
Assessment
Treatment
Long-term risks and benefits
Pre-menopausal oestrogen replacement
28: Male hypogonadism
Definition
Primary hypogonadism
Secondary hypogonadism
Late onset hypogonadism
Assessment
Treatment
29: Gynaecomastia
Definition
Causes
Assessment
Treatment
30: Infertility
Definition and aetiology
Evaluation of the infertile couple
Investigations
Management
Part 8: Neuroendocrine tumours
31: Neuroendocrine tumours
Definition
Aetiology
Symptoms and signs
Diagnosis
32: Neuroendocrine tumours: management
Treatment
Carcinoid heart disease
Prognosis
33: Inherited endocrine tumour syndromes
Multiple endocrine neoplasia type 1
Multiple endocrine neoplasia type 2
Carney complex
McCune–Albright syndrome
34: Spontaneous hypoglycaemia
Fasting hypoglycaemia
Postprandial hypoglycaemia
Assessment
Management
Part 9: Endocrine emergencies
35: Adrenal crisis
Clinical presentation
Management
36: Pituitary apoplexy
Clinical presentation
Management
37: Myxoedema coma
Clinical presentation
Management
38: Thyroid storm
Clinical presentation
Investigations
Management
39: Acute hyponatraemia
Clinical presentation
Management
40: Severe hypercalcaemia
Clinical presentation
Management
41: Acute hypocalcaemia
Clinical presentation
Management
Part 10: Diabetes mellitus
42: Overview
History
Landmark studies
Advances in care
Diabetes support organisations
Awareness
43: Diagnosis and monitoring
Diagnosis of diabetes
Oral glucose tolerance test
Impaired fasting glycaemia and impaired glucose tolerance
Screening
Monitoring diabetes
44: Classification
Type 1 diabetes
Type 2 diabetes
Maturity-onset diabetes of the young
Other genetic defects in β-cell function
Genetic defects in insulin action
Pancreatic diseases
Endocrine disorders
Drugs
Gestational diabetes
Other associations with diabetes
45: Type 1 diabetes: aetiology and clinical presentation
Aetiology
Pathophysiology
Clinical presentation
46: Type 1 diabetes: insulin and other therapies
Lifestyle
Insulin
Continuous subcutaneous insulin infusion
Pancreatic transplantation
The artificial pancreas
Immunotherapy
47: Type 2 diabetes: aetiology and clinical presentation
Aetiology
Pathophysiology
Clinical presentation
48: Type 2 diabetes: treatment
Diet and exercise
Metformin
Sulphonylureas
Meglitinides
Acarbose
Glitazones
DPP-4 inhibitors
GLP-1 receptor agonists
SGLT-2 inhibitors
Insulin
49: Macrovascular complications
Epidemiology
Aetiology
Clinical presentation
Management
50: Microvascular complications
Background
Aetiology
Neuropathy
Nephropathy
Retinopathy
51: Diabetic foot disease
Epidemiology
Aetiology
Clinical presentation
Management
Prognosis
52: Diabetic ketoacidosis
Definition and epidemiology
Aetiology
Symptoms and signs
Investigations
Management
Prognosis
53: Hyperglycaemic hyperosmolar state
Definition and epidemiology
Aetiology
Symptoms and signs
Investigations
Management
Prognosis
54: Hypoglycaemia
Definition and epidemiology
Aetiology
Symptoms and signs
Investigations
Management
Prognosis
55: Peri-operative management
Pathophysiological factors
Pre-operative management
Intra-operative management
Postoperative management
56: Management of acute illness
Aims of management
Monitoring
Drug management
Calorie and fluid intake
Special groups for consideration
57: Insulin infusions
Variable-rate intravenous insulin infusion
Fixed-rate intravenous insulin infusion
58: Pregnancy and diabetes
Epidemiology
Pathophysiology
Complications
Pre-conception care
Screening for GDM
Antenatal care
Peri- and postnatal care
Postnatal diabetes screening
59: Genetics of diabetes
Type 1 diabetes
Type 2 diabetes
Maturity onset diabetes of the young
Mitochondrial diabetes
Neonatal diabetes
Monogenic disorders of insulin resistance
60: The multidisciplinary team
Diagnosis and surveillance
Life stages
Disease stages
Setting
61: Lipid disorders
Primary hyperlipidaemias
Secondary hyperlipidaemias
62: Appetite and weight
Central regulation
Gut regulation
Long-term regulation
Clinical assessment
63: Obesity and anorexia
Obesity
Anorexia
Index
EULA
-
Osteoporosis (Oxford American Rheumatology Library)
La comanda in aproximativ 4 saptamani210.00 leiOsteoporosis is a common, underdiagnosed, and undertreated condition, complicated by fractures which lead to significant mortality and morbidity. The prevalence of osteoporotic fractures in postmenopausal women exceeds the combined prevalence of breast cancer, stroke, heart failure, and myocardial infarction. Often called "the silent disease," it does not reveal itself with obvious symptoms until a fracture occurs. In the first year after sustaining a hip fracture, mortality is increased by almost 24% in women and is even higher in men. About half of those who sustain an osteoporotic hip fracture become so disabled that they are no longer able to resume their daily activities, and as many as 20% require long-term institutional care. Effective treatments for osteoporosis are now available if it is diagnosed and addressed in a timely manner. Unfortunately, this disease remains shockingly underdiagnosed and undertreated, even in patients who sustain low-trauma hip fractures.
The past two decades have witnessed radical changes in the diagnosis and management of osteoporosis. The densitometric diagnosis of osteoporosis is noninvasive, quick, and relatively simple. Tools are now available to predict the patient's probability of sustaining fractures, to identify patients who are particularly vulnerable, and to determine which patients will benefit from further investigation and treatment. Various associations have developed guidelines to help clinicians reach a diagnosis and initiate treatment. Due to better understanding of the basic pathophysiology of bone turnover, potent and relatively safe medications that significantly reduce the risk of fractures are now widely available. It is of paramount importance that this disease be diagnosed and treated as early as possible in order to take advantage of these developments and reduce the enormous socioeconomic and psychological impact of osteoporosis.
Given the burden of osteoporotic fractures, all clinicians should have a working knowledge of e diagnosis, treatment, and prevention of the disease. Clinicians should feel comfortable diagnosing and initiating treatment for the majority of patients with osteoporosis. Only complicated cases or patients who are unresponsive to treatment should be referred to specialists. The aim of this book is to distill the available information on osteoporosis into an easily comprehensible format that will serve as a practical guide for busy clinicians. Numerous boxes, tables, diagrams, and figures present the information in an accessible manner. This book will be of particular use to general practitioners, endocrinologists, rheumatologists, gynecologists, internists, geriatricians, and orthopedic surgeons. -
215.00 lei
Description:
For more than 30 years, the highly regarded Secrets Series® has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Endocrine Secrets, 7th Edition, features the Secrets’ popular question-and-answer format that also includes lists, tables, pearls, memory aids, and an easy-to-read style - making inquiry, reference, and review quick, easy, and enjoyable.
Table Of Contents:
CHAPTER 1 DIABETES MELLITUS: ETIOLOGY, CLASSIFICATION, AND DIAGNOSIS
CHAPTER 2 DIABETES MELLITUS: ACUTE AND CHRONIC COMPLICATIONS
CHAPTER 3 TYPE 1 DIABETES MELLITUS
CHAPTER 4 TYPE 2 DIABETES MELLITUS
CHAPTER 5 DIABETES TECHNOLOGY: PUMPS, SENSORS, AND BEYOND
CHAPTER 6 CARBOHYDRATE COUNTING-GUIDED INSULIN DOSING: PRACTICE EXERCISES
CHAPTER 7 INPATIENT MANAGEMENT OF DIABETES AND HYPERGLYCEMIA
CHAPTER 8 DIABETES IN PREGNANCY
CHAPTER 9 HYPOGLYCEMIC DISORDERS
CHAPTER 10 LIPID DISORDERS
CHAPTER 11 OBESITY
CHAPTER 12 OSTEOPOROSIS AND OTHER METABOLIC BONE DISEASES: EVALUATION
CHAPTER 13 MEASUREMENT OF BONE MASS
CHAPTER 14 OSTEOPOROSIS MANAGEMENT
CHAPTER 15 OSTEOMALACIA, RICKETS, AND VITAMIN D INSUFFICIENCY
CHAPTER 16 PAGET’S DISEASE OF BONE
CHAPTER 17 HYPERCALCEMIA
CHAPTER 18 HYPERPARATHYROIDISM
CHAPTER 19 HYPERCALCEMIA OF MALIGNANCY
CHAPTER 20 HYPOCALCEMIA 164 Shari C. Fox
CHAPTER 21 NEPHROLITHIASIS 170
CHAPTER 22 PITUITARY INSUFFICIENCY
CHAPTER 23 NONFUNCTIONING PITUITARY TUMORS AND PITUITARY INCIDENTALOMAS
CHAPTER 24 PITUITARY STALK LESIONS
CHAPTER 25 PROLACTIN-SECRETING PITUITARY TUMORS
CHAPTER 26 GROWTH HORMONE-SECRETING PITUITARY TUMORS
CHAPTER 27 CUSHING’S SYNDROME
CHAPTER 28 GLYCOPROTEIN-SECRETING PITUITARY TUMORS
CHAPTER 29 WATER METABOLISM
CHAPTER 30 DISORDERS OF GROWTH
CHAPTER 31 GROWTH HORMONE USE AND ABUSE
CHAPTER 32 PRIMARY ALDOSTERONISM
CHAPTER 33 PHEOCHROMOCYTOMAS AND PARAGANGLIOMAS
CHAPTER 34 ADRENAL INCIDENTALOMAS
CHAPTER 35 ADRENAL MALIGNANCIES
CHAPTER 36 ADRENAL INSUFFICIENCY
CHAPTER 37 CONGENITAL ADRENAL HYPERPLASIA
CHAPTER 38 THYROID TESTING
CHAPTER 39 HYPERTHYROIDISM
CHAPTER 40 HYPOTHYROIDISM
CHAPTER 41 THYROIDITIS
CHAPTER 42 THYROID NODULES AND GOITER
CHAPTER 43 THYROID CANCER
CHAPTER 44 THYROID EMERGENCIES
CHAPTER 45 EUTHYROID SICK SYNDROME
CHAPTER 46 THYROID DISEASE IN PREGNANCY
CHAPTER 47 PSYCHIATRIC DISORDERS AND THYROID DISEASE
CHAPTER 48 DIFFERENCES (DISORDERS) OF SEXUAL
CHAPTER 49 DISORDERS OF PUBERTY
CHAPTER 50 MALE HYPOGONADISM
CHAPTER 51 ERECTILE DYSFUNCTION
CHAPTER 52 GYNECOMASTIA
CHAPTER 53 AMENORRHEA
CHAPTER 54 POLYCYSTIC OVARIAN SYNDROME
CHAPTER 55 HIRSUTISM AND VIRILIZATION
CHAPTER 56 MENOPAUSE
CHAPTER 57 G ENDER-AFFIRMING TREATMENT FOR ADULTS WITH GENDER INCONGRUENCE AND GENDER DYSPHORIA
CHAPTER 58 U SE AND ABUSE OF ANABOLIC-ANDROGENIC STEROIDS AND ANDROGEN PRECURSORS
CHAPTER 59 AUTOIMMUNE POLYGLANDULAR SYNDROMES
CHAPTER 60 MULTIPLE ENDOCRINE NEOPLASIA SYNDROMES
CHAPTER 61 PANCREATIC NEUROENDOCRINE TUMORS
CHAPTER 62 CARCINOID SYNDROME
CHAPTER 63 AGING AND ENDOCRINOLOGY
CHAPTER 64 ENDOCRINOPATHIES CAUSED BY IMMUNE CHECKPOINT INHIBITORS
CHAPTER 65 SLEEP AND ENDOCRINOLOGY
CHAPTER 66 THYROID AND PARATHYROID SURGERY
CHAPTER 67 ADRENAL SURGERY
CHAPTER 68 PANCREAS AND OTHER ENDOCRINE TUMOR SURGERY
CHAPTER 69 BARIATRIC SURGERY
CHAPTER 70 ENDOCRINOLOGY IN AFRICA
CHAPTER 71 FAMOUS PEOPLE WITH ENDOCRINE DISORDERS
CHAPTER 72 INTERESTING ENDOCRINE FACTS AND FIGURES
CHAPTER 73 ENDOCRINE CASE STUDIES -
260.00 lei
Description:
Providing summaries of the latest and best publications, clinical trials, and evidence in endocrinology, this portable handbook is a time-saving addition to your professional library. In a concise, easy-to-read format, it offers evidence-based recommendations for the diagnosis and treatment of endocrine disorders and provides a comprehensive summary of pertinent clinical studies supporting the practice recommendations
Table of Contents:
Chapter 1 Hypothalamic Pituitary Disease
Introduction of the Hypothalamic–Pituitary Axis
Pituitary Adenomas and Sellar Masses
Hypopituitarism
Imaging of the Hypothalamic–Pituitary System
Disorders of the Prolactin System
Acromegaly
Thyroid-Stimulating Hormone Secreting Pituitary Adenomas
Cushing Disease
Diabetes Insipidus
SIADH
References
Chapter 2 Thyroid Disorders
Evaluation of Thyroid Function
Thyroid Imaging
Hyperthyroidism
Hypothyroidism
Thyroid Nodules
Thyroid Cancer
Euthyroid Sick Syndrome
References
Chapter 3 Adrenal Disorders
Evaluation of Adrenal Function
Adrenal Imaging
Primary Hyperaldosteronism
Cushing Syndrome
Adrenal Incidentaloma
Adrenal Insufficiency
Pheochromocytoma
References
Chapter 4 Metabolic Bone Disorders
Evaluation of Metabolic Bone Disorders
Bone Imaging
Osteoporosis
Paget Disease of the Bone
Primary Hyperparathyroidism
Parathyroid Carcinoma
Hypercalcemia
Hypocalcemia
Osteomalacia
Vitamin D Deficiency
References
Chapter 5 Reproductive Disorders
Amenorrhea
Precocious Puberty
Hyperandrogenism
Polycystic Ovary Syndrome
Menopause
Infertility
Male Hypogonadism
References
Chapter 6 Diabetes Mellitus
Epidemiology and Prevalence
Types of Diabetes Mellitus
Clinical Presentation
Screening for Diabetes
Assessing Glycemic Control
Treatment of Diabetes
Inpatient Diabetes Management
Macrovascular Complications of Diabetes
The Impact of Multifactorial Intervention
The Cardiovascular Impact of Treatment of Hyperglycemia
The Cardiovascular Impact of Treatment of Hypertension
The Cardiovascular Impact of Treatment of Hyperlipidemia
The Cardiovascular Impact of Antiplatelet Therapy
Microvascular Complications of Diabetes
Hypoglycemia
Prevention of Diabetes Mellitus
References
Chapter 7 Lipid Disorders
Introduction
Treatment Options for Lowering LDL Cholesterol
Clinical Outcomes Data with PCSK9 Inhibition
Future Studies with PCSK9 Inhibitors
High-Density-Lipoprotein Cholesterol and Triglycerides
Treatment Options for Triglycerides
Summary
References
Chapter 8 Obesity
Definition
Epidemiology
Etiology
Pathophysiology
Evaluation
Treatment
Pharmacotherapy
Bariatric/Metabolic Surgery
References
Chapter 9 Multiple Endocrine Neoplasia
MEN Type 1
MEN Type 2
References
Chapter 10 Carcinoid Tumors
Definition
Pathology
Biology
Epidemiology
Diagnosis
Treatment
Summary
References
Chapter 11 Paraneoplastic Endocrine Syndromes
Hypercalcemia of Malignancy
Hypocalcemia
Tumor-Induced Osteomalacia
Ectopic Adrenocorticotropic Hormone Syndrome
Non–Islet Cell Tumor–Induced Hypoglycemia
Acromegaly
Hyperthyroidism
References
Chapter 12 Genetics
Definition
Etiology
Epidemiology
Pathophysiology
Diagnosis
References
Chapter 13 Transgender Care
Introduction
Definitions
Mental Health
Gender-Affirming Hormone Therapy in Adults
Special Considerations in Management of Gender Nonconforming Children and Transgender Youth
Gender-Affirming Surgery
Conclusion
References
Index
-
Diabetes: Epidemiology, Pathophysiology and Clinical Management
La comanda in aproximativ 4 saptamani260.00 leiDescription:
Diabetes: Epidemiology, Pathophysiology and Clinical Management aims to be the one-stop diabetes book for researchers, scientists and clinicians. It details the epidemiology, causes, molecular mechanisms, molecular markers, available drugs, experimental drugs, treatment modalities, and dietary and lifestyle approaches related to diabetes. It focuses on various molecular aspects of diabetes, and its related co-morbidities. Apart from the drug-based treatment approach based on international guidelines, this book also describes various surgical treatments available for cases of uncontrolled symptomatic diabetes. It also lays emphasis on the future possibilities of different approaches for diabetes management. Key Features Includes treatment guidelines and approaches to diabetes provided by major global diabetes associations Provides a thorough and comprehensive assimilation of detailed information and updates in the field of diabetes, helpful for researchers, scientists and clinicians Contains a chapter on anti-diabetic drugs, that covers both the commercially approved drugs as well as those that are in various phases of experimental, pre-clinical, and clinical trials
Table of Contents:
Chapter 1 Diabetes Epidemiology – 1980 and Beyond
Face-to-Face with the Global Diabetes Epidemiology
References
Chapter 2 Diabetes and Inflammation
Introduction
General Mechanism of Inflammation-Induced Insulin Resistance
Macrophage Activation and Insulin Resistance in Obesity
Role of Pro-Inflammatory Cytokines in Diabetes
Tumour Necrosis Factor – α
Interleukins
C – Reactive Protein (CRP)
Toll-Like Receptors
Conclusions
References
Chapter 3 Insulin Resistance and Glucose Regulation
Introduction to Insulin Resistance
Obesity as a Cause of Insulin Resistance
Free Fatty Acids
Adiponectin
TNF-α
Resistin and Interleukin-6
Leptin
Fibroblast Growth Factor 21
Dietary Effect on Insulin Resistance
Fatty Acid Mediated Insulin Resistance
Fructose-Induced Insulin Resistance
Conclusions
References
Chapter 4 Diabetes : A Leading Contributor to Other Disease Complications
Introduction
Pathophysiology of T2DM
Diabetes-Related Complications
Diabetic Retinopathy
Cardiovascular Disorders
Diabetic Nephropathy
Diabetic Neuropathy
Pulmonary Dysfunctions
Hepatic Dysfunction
Other Complications
Periodontitis
Genito-Urinary Infections
Tuberculosis
Gastroparesis
Conclusions
References
Chapter 5 Biomarkers of Diabetes
Biomarkers
Biomarkers for T1DM
Biomarkers for T2DM
Glycated Haemoglobin (HbA1c)
1, 5-Anhydroglucitol (1,5-AG)
Uric Acid
Chromogranin A
Skin and Lens Autofluorescence
References
Chapter 6 Anti-Diabetic Drugs
Introduction
Parenteral Anti-Diabetic Drugs (Insulin)
Oral Anti-Diabetic Drugs
Drugs for Diabetes Insipidus
Drugs from the Labs: The Story of Possibilities
GK Activators
FGF21 Mimetics
PTP-1B Inhibitors
RAGE Inhibitors
References
Chapter 7 Diagnosis and Treatment
Diagnosis of Diabetes
Pharmacological Treatment of Diabetes
Surgical Treatment of Diabetes
References
Chapter 8 Dietary and Lifestyle Management of Diabetes
Importance of Dietary and Lifestyle Management in Diabetes
Metabolic Effects of Exercise
Gut Microbiome and Diabetes: Old Companion with a New Angle
References
Chapter 9 Future Prospects and Recommendations
Index
-
Endocrine Pathophysiology: A Concise Guide to the Physical Exam
La comanda in aproximativ 4 saptamani33700lei 295.00 leiDescription:
This practical guide presents a concise approach to exploring endocrine pathophysiology through the physical exam, emphasizing common clinical signs in endocrinology that can be elicited through inspection, palpation, percussion or auscultation. The established and proposed mechanisms underlying these physical signs are highlighted, allowing students, residents and trainees to better appreciate endocrine pathophysiology at the bedside. The text is organized sensibly to facilitate quick and efficient review by medical trainees. Major diseases in endocrinology are grouped by organ systems - pituitary, thyroid, adrenal, and so on. Specific physical examination findings in each primary endocrine disease are reviewed and grouped under the categories of clinical features and pathophysiology, followed by related clinical and pathophysiology pearls. A brief description of the clinical finding is followed by a summary of the pathophysiologic mechanisms underlying the stated clinical finding. Relevant normal physiology and pathophysiology are reviewed where applicable, to facilitate learning. There are numerous texts on the pathophysiologic basis of diagnostic and laboratory findings in endocrinology. There is, however, no dedicated text to address questions that might be asked by trainees. Endocrine Pathophysiology satisfies this need in the literature.
Table of Contents:
1. Pituitary Gland Signs
2. Thyroid Gland Signs
3. Adrenal Gland Signs
4. Pancreatic Gland Signs
5. Parathyroid Gland and Musculoskeletal Signs
6. Reproductive Organ Signs
7. Signs in Disorders of Lipid Metabolism and Obesity
8. Eponymous Terms and Selected Historical Figures in Endocrinology
-
Manual of Endocrinology and Metabolism (Lippincott Manual Series)
La comanda in aproximativ 4 saptamani320.00 leiDescription:
Ideal for all health care professionals who evaluate, diagnose, treat, or refer patients with endocrine disease or disorders, Manual of Endocrinology and Metabolism, Fifth Edition, brings together nearly 150 global authorities who share their knowledge and expertise on endocrine disorders in children, adolescents, and adults. Using a concise outline format, this thoroughly updated manual presents clinical information and protocols needed in everyday practice, with an emphasis on diagnosis and treatment. Succinct chapters and an abundance of tables and diagrams make complex information easy to find and understand.
Table of Contents:
Section 1 Basic Science of Clinical Endocrinology
1 Clinical Molecular Endocrinology Laboratory Testing
2 Hormone-Resistant States
3 Genetics of Endocrinology
4 The Growth Plate
Section 2 Hypothalamic-Pituitary Dysfunction
5 Anterior Pituitary Diseases
6 Hypopituitarism after Traumatic Brain Injury
7 Prolactin
8 Nipple Discharge/Galactorrhea
9 Acromegaly/Gigantism
10 Clinical Disorders of Vasopressin
11 Preoperative, Intraoperative, and Postoperative Management Following Pituitary Surgery
12 Growth Hormone in Adults
13 Pituitary Disorders and Tall Stature in Children
14 Short Stature and Growth Hormone Therapy
15 Laron Syndrome
16 Prader–Willi Syndrome
Section 3 Adrenal Disorders
17 The Adrenal Cortex and Mineralocorticoid Hypertension
18 Pheochromocytoma and Paraganglioma
19 Hormonal Hypertension
20 Use of Salivary Cortisol Assay to Screen for Cushing Syndrome/Disease
21 Adrenal Hormones during Acute and Chronic Illness: Evaluation and Treatment
22 Congenital Adrenal Hyperplasia
23 Adrenal Steroid Excess in Childhood
24 Adrenal Insufficiency in Childhood
Section 4 Disorders of the Reproductive System
25 Female Reproductive Endocrinology in Adults
26 Polycystic Ovary Syndrome
27 Male Reproductive Disorders in Adults
28 Disorders of Sexual Development in the Pediatric and Adolescent Male
29 Early, Precocious, and Delayed Female Pubertal Development
30 Ambiguous Genitalia
Section 5 Mineral Disorders
31 Disorders of Calciotropic Hormones in Adults
32 Hypercalcemic Crisis
33 Metabolic Bone Disease
34 Parathyroid Hormone-Related Protein
35 Common Bone and Mineral Disorders of Childhood
Section 6 Thyroid Disorders
36 Evaluation of Thyroid Function
37 Thyroiditis
38 Hypothyroidism and Hyperthyroidism
39 Thyroid Tumors in Adults
40 Newborn Thyroid Disorders and Screening
41 Thyroid Nodules and Thyroid Cancer in Children and Adolescents
42 Thyroid Disorders in Children and Adolescents
Section 7 Metabolic Disorders
43 Obesity
44 Disorders of Lipid Metabolism
45 Hypoglycemia in Adults
46 Hypoglycemia in Infants and Children
47 Congenital Hyperinsulinism
Section 8 Inborn Errors of Metabolism
48 Introduction to Inborn Errors of Metabolism
49 Glycogen Storage Diseases
50 Hypokalemic Paralysis
Section 9 Diabetes Mellitus
51 Etiology, Pathogenesis, and Therapy of Type 1 Diabetes Mellitus
52 Diagnosis and Management of Type 1 Diabetes Mellitus in Children, Adolescents and Young Adults
53 Hypoglycemia-Associated Autonomic Failure (HAAF) in Diabetes Mellitus
54 Diabetic Ketoacidosis
55 Type 2 Diabetes Mellitus
56 Glucose Control in Glucocorticoid-Induced Hyperglycemia
57 Bariatric Surgery in Adults with Type 2 Diabetes
58 Diabetes Mellitus and the Geriatric Patient
59 Diabetes Mellitus Type 2, Obesity, Dyslipidemia, and the Metabolic Syndrome in Children
60 Type 1.5 Diabetes: Overlay between Type 1 and Type 2 Diabetes
61 C-Peptide
62 Cystic Fibrosis Related Diabetes
63 Diabetes in Pregnancy
64 Management of Diabetes Mellitus in the Perioperative Period
65 Diabetes Mellitus: Recent Developments and Clinical Implications
66 Artificial Pancreas
67 Glycated Proteins in the Diagnosis and Management of Type I and Type II Diabetes Mellitus
68 Inhaled Insulin
69 The Application of Stem Cells in Diabetes Mellitus
Section 10 Sex Hormone Treatments
70 The Care of Gender-nonconforming and Transgender Youth
71 Hormone Therapy in Transgender Adults
72 How to Manage Men with Low Testosterone
73 The Use of Hormones in Female Sexual Dysfunction
74 Menopausal Hormone Therapy
Section 11 Special Topics in Clinical Endocrinology
75 Endocrine Diseases in Pregnancy
76 Fetal Endocrinology and Neonatal Emergencies
77 Hormones and Aging
78 Neuroendocrine (APUD) Syndromes
79 Multiple Endocrine Neoplasia Syndromes
80 Radiology, Nuclear Medicine, and Endocrinology
81 Surgery for Endocrine Disorders
82 Surgical Management of Pediatric Endocrine Diseases
83 Biomarkers Used in the Screening, Diagnosis, Management, and Surveillance of Endocrine Cancers
84 Autoimmune Endocrine Syndromes
85 Management of Some Hormone-Dependent Cancers with Analogs of Hypothalamic Hormones
86 Endocrine-Disrupting Chemicals
87 Flushing and Sweating
88 Intranasal Hormones
89 The Female Athlete
Appendix A Protocols for Stimulation and Suppression Tests Commonly Used in Clinical Endocrinology
Index
-
Endocrinology Adult and Pediatric: Diabetes Mellitus and Obesity, 6th Edition
La comanda in aproximativ 4 saptamani325.00 leiDescription:
Meet the growing challenges of diabetes and obesity management with Diabetes Mellitus and Obesity, a compilation of chapters from the highly acclaimed two-volume textbook, Endocrinology: Adult and Pediatric. Never before available as a stand-alone offering, this derivative book will enable you to put today's best endocrinology practices in diabetes and obesity management to work for your patients.
Features:
Stay abreast of the newest knowledge and advances in diabetes and obesity management, including
today's increased focus on controlling autoimmunity and preserving or replenishing beta-cell mass in the management of type 1 diabetes
complications of diabetes and their pathogenesis, morbidity, and treatment
new findings and treatments for obesity
and much more.
Make the best clinical endocrinology decisions with an enhanced emphasis on evidence-based practice in conjunction with expert opinion.
Count on all the authority that has made Endocrinology, 6th Edition, edited by Drs. Jameson and De Groot, the go-to clinical medical reference for endocrinologists worldwide.
Table Of Contents:
Appetite Regulation and Thermogenesis
Obesity: The Problem and Its Management
Genetic Syndromes Associated with Obesity
Anorexia Nervosa, Bulimia Nervosa, and Other Eating Disorders
Development of the Endocrine Pancreas
Biosynthesis, Processing, and Secretion of the Islet Hormones: Insulin, Islet Amyloid Polypeptide (Amylin), Glucagon, Somatostatin, and Pancreatic Polypeptide
Insulin Secretion
The Mechanisms of Insulin Action
Glucagon and Glucagon-like Peptides
Regulation of Intermediatory Metabolism During Fasting and Feeding
Role of the Adipocyte in Metabolism and Endocrine Function
Lipodystrophy Syndromes
Classification and Diagnosis of Diabetes Mellitus
Type 1 (Insulin-dependent) Diabetes Mellitus: Etiology, Pathogenesis, Prediction, and Prevention
Type 2 Diabetes Mellitus: Etiology, Pathogenesis, and Natural History
Lipoprotein Metabolism and the Treatment of Lipid Disorders
Hyperglycemia Secondary to Nondiabetic Conditions and Therapies
The Metabolic Syndrome
Treatment of Type 1 Diabetes Mellitus in Adults
Ketoacidosis and Hyperosmolar Coma
Hypoglycemia and Hypoglycemic Syndromes
Management of Type 2 Diabetes Mellitus
Management of Diabetes Mellitus in Children
Pancreatic and Islet Transplantation
Diabetes Control, Long-Term Complications, and Large Vessel Disease
Diabetic Eye Disease
Diabetes Mellitus: Neuropathy
Diabetic Nephropathy
Diabetic Foot and Vascular Complications
Diabetes Mellitus and Pregnancy
Bottom of Form
-
Essentials of Endocrinology and Metabolism: A Practical Guide for Medical Students
La comanda in aproximativ 4 saptamani36500lei 330.00 leiDescription:
Developed from time-tested material utilized in endocrinology courses for medical students, this comprehensive and practical guide draws together a number of related disciplines to create a straightforward and accessible approach to the study of endocrine and metabolic diseases. Designed with the student in mind, each of the main endocrine organs and disorders are covered in thematic sections on diabetes, thyroid disorders, calcium disorders, adrenal disorders, and hypothalamus and pituitary disorders. Opening with clear learning objectives, chapters within each section discuss core concepts, anatomy, embryology, histology, testing, diagnosis and pharmacology, and include clinical case scenarios and multiple choice review questions. Full-color figures and diagrams enhance and extend the content. Perfect for in-class reference or board licensing review, Essentials of Endocrinology and Metabolism is an indispensable resource for medical and nursing students alike.
Table of Contents:
1. Introduction to Endocrinology Concepts
Part I. Diabetes
2. Getting Prepared Series for Diabetes
3. Diabetes Types and Diagnosis
4. Diabetes Complications
5. Diabetes Pharmacology
6. Diabetes Cases
Part II. Thyroid
7. Getting Prepared Series for Thyroid
8. Abnormal Thyroid Function
9. Thyroid Testing
10. Thyroid Pharmacology
11. Thyroid Nodules and Cancer
12. Thyroid Cases
Part III. Calcium
13. Getting Prepared Series for Calcium
14. Hypercalcemia
15. Hypocalcemia
16. Calcium Pharmacology
17. Calcium Cases
Part IV. Adrenal
18. Getting Prepared Series for Adrenal
19. Adrenal Cortex
20. Adrenal Testing
21. Adrenal Pharmacology
22. Secondary Hypertension
23. Adrenal Cases
Part V. Hypothalamus and Pituitary
24. Getting Prepared Series for Pituitary
25. Prolactin
26. Growth Hormone
27. Reproductive Function
28. Posterior Pituitary
29. Pituitary Cases
30. Puberty Cases
Back Matter
-
Pubertal Suppression in Transgender Youth, 1e
La comanda in aproximativ 4 saptamani47800lei 420.00 leiDescription:
Offering current guidelines on the relatively new practice of puberty suppression for gender-dysphoric adolescents, Pubertal Suppression in Transgender Youth provides a succinct, easy-to-digest overview of this timely topic. This concise, clinically-focused resource by Dr. Courtney Finlayson covers all relevant topics, from a brief history of medical care of transgender youth to emerging developments in the field.
Table of Contents
· Copyright
· List of Contributors
· Chapter 1. History of Care of Transgender Youth
· Dedication
· Chapter 2. Models of Care and Current Guidelines for Care of Transgender Individuals
· Gender-Affirming Care
· Multidisciplinary Care
· Practice Guidelines
· Mental Healthcare
· Medical Care
· Adjunctive Services
· Barriers to Care
· Summary
· Chapter 3. Puberty
· Physical Changes Associated With Puberty
· Physiology of Puberty
· Delayed Puberty or Absent Puberty (Sexual Infantilism)
· Precocious Puberty (Sexual Precocity)
· Chapter 4. GnRH Analogs (Mechanism, Past Studies, Drug Options, Use in Precocious Puberty, Use in Gender-Nonconforming Youth)
· Historical Perspective
· Physiology and Mechanism of Action
· Use in Central Precocious Puberty
· Outcomes in Central Precocious Puberty
· Use in Gender-Nonconforming Youth
· Options for Treatment
· Outcomes in Gender-Nonconforming Youth
· Challenges in Care
· Conclusion
· Chapter 5. Rationale for the Initiation, Use, and Monitoring of GnRHa in Gender Non-conforming Youth
· Introduction
· Rationale
· Initiation
· Monitoring
· Conclusion
· Chapter 6. Psychosocial Considerations in Pubertal Suppression Treatment
· Introduction
· Possible Effects of Gonadotropin-Releasing Hormone Analogues on Gender Identity and/or Sexuality Development
· Unknown Neurocognitive Sequelae of Pubertal Suppression Treatment
· Psychosocial Implications of Known Medical Side Effects of Gonadotropin-Releasing Hormone Analogue Treatment
· Family Factors
· Conclusion
· Chapter 7. Medical Side Effects of GnRH Agonists
· Bone Health
· Brain
· Fertility
· Body Mass Index and Body Composition
· Summary
· Chapter 8. Surgical Side Effects of GnRHa
· Introduction
· Goals of Surgery
· Timing of Surgery
· Surgical Considerations for Individuals on GnRHa
· Areas of Uncertainty
· Conclusion
· Chapter 9. Fertility Preservation: Considerations for Gender-Diverse Youth
· Risk of Infertility due to Hormonal Therapies
· Fertility Preservation Options in Birth-Assigned Males
· Fertility Preservation Options in Birth-Assigned Females
· Attitudes Toward FP and Other Psychological Considerations
· Ethical Considerations
· Financial Considerations
· Future Directions
· Conclusions
· Chapter 10. Duration of Pubertal Suppression and Initiation of Gender-Affirming Hormone Treatment in Youth
· Pubertal Suppression and Gender-Affirming Hormone Therapies
· Relevant Time Points in Clinical Guidelines and Protocols
· Unresolved Questions
· Case Examples
· Initiation of Gender-Affirming Hormones
· Testosterone
· Estrogen
· Conclusions
· Chapter 11. Ethical Considerations of GnRHa Treatment and Consent Process
· Introduction
· Pubertal Suppression
· Benefits of Pubertal Suppression
· Ethical Issues
· Conclusion
· Chapter 12. Emerging Developments in Pubertal Suppression for Gender Incongruent/Gender Dysphoric Youth
· Triptorelin, a New Gonadotropin-Releasing Hormone Agonist
· Prolonged Use of Histrelin acetate implant in Transgender Youth
· Gonadotropin-Releasing Hormone Agonist Use in Nonbinary Youth
· Gonadotropin-Releasing Hormone and Gonadotropin Antagonists
· Kisspeptin and Neurokinin B Antagonists
· Oxandrolone as an Alternative Gender-Affirming Masculinizing Hormone
· Low-Dose Estrogen and Testosterone
· Antiandrogens and Androgen Receptor Inhibitors
· Antiandrogens
· Conclusion
-
Advances in Treatment and Management in Surgical Endocrinology
La comanda in aproximativ 4 saptamani46000lei 430.00 leiDescription:
Up-to-date and evidence-based, Updates on Treatment and Management of Endocrinopathies [correct title?] provides an overview of recent developments regarding the most prevalent endocrine disorders. A concise, easy-to-read reference for endocrinologists and endocrine surgeons, this timely reference includes an overview of each disorder as well as diagnosis, management, treatment, prognosis, and a summary by a renowned expert who has contributed to the most current literature.
Features:
• Addresses endocrine diseases of the thyroid, parathyroid and adrenal glands as well as familial endocrine syndromes - multiple endocrine neoplasia type 1 and 2 (MEN).
• Includes both surgical and non-surgical treatments
• Consolidates today's available information on this timely topic into one convenient resource.
Table Of Contents:
1 Advances in the Diagnosis and Management of Papillary Thyroid Microcarcinoma
2 Advances in the Diagnosis and Surgical Management of Medullary Thyroid Carcinomas
3 Management of Undifferentiated (Anaplastic) Thyroid Cancer
4 Familial Nonmedullary Thyroid Cancer
5 Thyroid Cancer in Children and Adolescents
6 Brief Overview of Calcium, Vitamin D, Parathyroid Hormone Metabolism, and Calcium-Sensing Receptor Function
7 Advances in the Diagnosis and Surgical Management of Primary Hyperparathyroidism
8 Advances in Diagnosis and Management of Secondary and Tertiary Hyperparathyroidism
9 Advances in the Diagnosis and SurgicalManagement of Parathyroid Carcinoma
10 Advances in the Diagnosis and Management of Primary Hyperparathyroidism due to MEN Type 1 Syndrome
11 Advances in Diagnosis and Management of Primary Hyperparathyroidism due to Multiple Endocrine Neoplasia (MEN) Type 2 Syndrome
12 Advances in Diagnosis and Management of Primary Hyperparathyroidism During Pregnancy
13 Update on the Diagnosis and Management of Primary Aldosteronism
14 Update on Diagnosis and Management of Pheochromocytoma
15 Advances in the Diagnosis and Medical Management of Cushing’s Syndrome
16 Advances in the Diagnosis and Management of Adrenocortical Carcinoma
17 Adrenal Vein Sampling
18 Advances in the Diagnosis and Management of Insulinoma
19 Advances in the Diagnosis and Management of Gastrinoma
20 Advances in the Diagnosis and Management of Nonfunctional Pancreatic Neuroendocrine Tumors
21 Pituitary Adenomas: Evaluation and Management From a Surgical Perspective
22 Advances in the Orbital Decompressive Surgery for the Treatment of Graves’ Ophthalmopathy
23 Advances in the Minimally Invasive Surgical Approaches to Thyroid, Parathyroid, and Adrenal Disorders
24 Advances in Transoral Endoscopic Thyroidectomy Vestibular Approach(TOETVA)
25 Advances in Perioperative Management: Nursing Care, Anesthesia Considerations, and Nurse Navigation for Endocrine Surgical Patients -
47500lei 450.00 lei
Imaging in Endocrinology will provide endocrinologists and radiologists of all levels with an outstanding diagnostic imaging atlas to aid them in the diagnosis and management of all the major endocrine diseases they are likely to encounter. In full colour throughout, the 300 high–quality images consist of CT scans, MRI, NMR and histopathology slides, and are arranged by each specific endocrine condition, resulting in a visually outstanding and easily accessible tool that guides the user through exactly what to look out for and provides a practical and extremely useful aid in helping them formulate a diagnosis.
Every major endocrine condition is covered in a specific section, including diseases of the thyroid, pituitary, reproductive and adrenal glands, the pancreas, bone metabolism problems, and the various forms of endocrine cancers. Each disease covered will offer a comparison of the normal findings so as to further assist in diagnosis.
An accompanying website contains an online slide–atlas of all the figures in the book, to allow users to download all figures for use in presentations. Led by Paolo Pozzilli, an internationally–recognised expert in this field, the authors have assembled a wonderful collection of images that will be greatly valued by endocrinologists and radiologists alike, ensuring this is the perfect tool to consult when assessing patients with endocrine disease. -
Practical Endocrinology and Diabetes in Children
La comanda in aproximativ 4 saptamani49100lei 460.00 leiThe revised and updated fourth edition of Practical Endocrinology and Diabetes in Children offers a practical, highly clinical and up-to-date handbook of paediatric endocrinology and diabetes. The book is written in clear terms and offers a user-friendly format that is designed to be concise, yet comprehensive.. The international panel of expert contributors explore the range of endocrine disorders in children including growth, thyroid, adrenal and problems related to puberty.
-
The Diabetes Textbook: Clinical Principles, Patient Management and Public Health Issues
La comanda in aproximativ 4 saptamani500.00 leiAbout this Textbook
The purpose of this textbook is multiple: to offer a comprehensive resource covering all aspects of outpatient management; to address diabetes as a health problem from an epidemiological, economic and clinical perspective; to discuss the role of social determinants of health on the worldwide increase in diabetes; to highlight the challenges and obstacles in providing adequate care; and to outline a multidisciplinary approach to management in which medical visits retain their importance as part of a team comprising the patient, his or her family and a multidisciplinary group of health professionals who are able to move beyond the traditional approach of diabetes as a disease and greatly improve outcomes.Table of contents (64 chapters)
Preface: A New Disease?
Pages 1-8
Rodriguez-Saldana, Joel
The Dynamics of Diabetes Prevalence, Morbidity, and Mortality
Pages 11-21
Gregg, Edward W. (et al.)
Economic Costs, from Individuals to Health Systems: Evidence from a Middle-Income Country
Pages 23-32
Arredondo, Armando (et al.)
The Ecological Approach to Self-Management in Diabetes
Pages 33-59
Fisher, Edwin B. (et al.)
Social Determinants of Health and Diabetes Outcomes
Pages 61-69
Hashimoto, Hideki
Definition, Diagnostic Criteria, Screening, Diagnosis, and Classification of Diabetes and Categories of Glucose Intolerance
Pages 71-85
Nandhini, Lakshmana Perumal (et al.)
Pathophysiology of Type 1 Diabetes
Pages 89-99
Gómez-Díaz, Rita A.
Pathophysiology of Type 2 Diabetes
Pages 101-116
Kesavadev, Jothydev (et al.)
Genetic Determinants of Type 2 Diabetes
Pages 117-125
Cruz, Miguel (et al.)
Gene Expression Modifications in Type 2 Diabetes
Pages 127-144
Suarez-Sanchez, Fernando (et al.)
The Immune System and Inflammation in Type 2 Diabetes
Pages 145-167
Macedo, Rebeca García
Dysfunction and Death of Pancreatic Beta Cells in Type 2 Diabetes
Pages 169-184
Ortega-Camarillo, Clara
Obesity in the Pathophysiology of Diabetes
Pages 185-213
Paniagua González, Juan Antonio (et al.)
Pathogenesis of Gestational Diabetes Mellitus
Pages 215-225
Kintiraki, Evangelia (et al.)
Non-alcoholic Fatty Liver in the Pathogenesis of Diabetes
Pages 227-235
Villela Nogueira, Cristiane A. (et al.)
Diabetes Management in Asia
Pages 239-253
Shivashankar, Roopa (et al.)
Diabetes Management in the United States
Pages 255-271
Ali, Mohammed K. (et al.)
Diabetes Management in Africa
Pages 273-288
Choukem, Simeon Pierre (et al.)
The Patient-Centered Medical Home, Primary Care, and Diabetes
Pages 291-304
Rodriguez-Saldana, Joel
Outpatient Diabetes Management and the Chronic Care Model
Pages 305-332
Rodriguez-Saldana, Joel
Clinical Practice Guidelines, Evidence-Based Medicine, and Diabetes
Pages 333-355
Rodriguez-Saldana, Joel
Measuring Diabetes Quality of Care: Clinical Outcomes, Cost-Effectiveness, and Patient Experience of Care
Pages 357-365
O’Connor, Patrick J. (et al.)
Clinical Inertia: The Role of Physicians in Diabetes Outcomes
Pages 367-380
Rodriguez-Saldana, Joel
Patient Adherence: Challenges, Myths, and Realities
Pages 381-400
Rodriguez-Saldana, Joel
Challenges and Opportunities in Diabetes Education
Pages 403-416
Dickinson, Jane K. (et al.)
Diabetes and Mental Health: From Distress to Depression
Pages 417-428
Heinze, Gerhard (et al.)
Tools of Self-Care: Self-Monitoring of Blood Glucose and Tele-Health Resources
Pages 429-450
Ginsberg, Barry H.
Continuous Glucose Monitoring in Clinical Practice: Ambulatory Glucose Profile and the Application of Advanced Glucose Sensing Technologies to Clinical Decision-Making
Pages 451-462
Mazze, Roger S.
Type 2 Diabetes and Lifestyle Medicine
Pages 463-476
Galaviz, Karla I. (et al.)
Evidence and Implementation of Medical Nutrition Therapy in Persons with Diabetes
Pages 477-483
Maryniuk, Melinda Downie (et al.)
Evidence and Implementation of Physical Activity and Exercise
Pages 485-498
Jáuregui-Ulloa, Edtna (et al.)
The “Old” Oral Antidiabetics
Pages 501-513
Buhse, Susanne (et al.)
Incretin Therapies: Current Use and Emerging Possibilities
Pages 515-529
Schlögl, Haiko (et al.)
Sodium-Glucose Cotransporter 2 Inhibitors
Pages 531-539
Dailey, George, III (et al.)
Use of Insulin in Outpatient Diabetes Management
Pages 541-554
Faradji, Raquel N. (et al.)
Insulin Pump Therapy
Pages 555-570
Faradji, Raquel N. (et al.)
Diabetes and Hypertension
Pages 573-585
Khangura, D. (et al.)
Diabetes and Atherogenic Dyslipidemia
Pages 587-596
Mooradian, Arshag D.
Obesity and Diabetes
Pages 597-610
Wharton, Sean (et al.)
Diabetes and Smoking: The Burden of Evidence
Pages 611-616
Aggarwal, Sameer (et al.)
Diabetic Ketoacidosis
Pages 619-627
Umpierrez, Guillermo E.
Hypoglycemia: Diagnosis, Management, and Prevention
Pages 629-653
Faradji, Raquel N. (et al.)
Inpatient Management of Diabetes and Hyperglycemia
Pages 655-668
Horton, William B.
Diabetes and Infection
Pages 669-691
Atreja, Atulya (et al.)
Biochemical Mechanisms of Vascular Complications in Diabetes
Pages 695-707
Margarita Díaz-Flores, (et al.)
Diabetes and Cardiovascular Disease
Pages 709-730
Coutiño-Castelán, Daniel (et al.)
Diabetes and Stroke: The Role of Glucose Regulation
Pages 731-746
Lowe, Forrest (et al.)
Peripheral Arterial Disease and Diabetes Mellitus
Pages 747-763
Cheun, Tracy J. (et al.)
Ophthalmic Disease in Diabetes
Pages 765-775
Henriques, José (et al.)
Diabetes and Oral Health
Pages 777-790
Díaz-Romero, Rosa Maria (et al.)
Renal Disease in Diabetes
Pages 791-807
Garza-García, Carlos A. (et al.)
Peripheral Diabetic Neuropathies
Pages 809-823
Feher, Gergely
Diabetic Cardiac Autonomic Neuropathy
Pages 825-850
Serhiyenko, Viktoria (et al.)
Autonomic Visceral Neuropathy and Gastrointestinal Disorders
Pages 851-861
Drewes, Anne Mohr (et al.)
Urologic Complications in Patients with Diabetes
Pages 863-871
Casco, Stephania (et al.)
Musculoskeletal Complications of Diabetes Mellitus
Pages 873-881
Singla, Rajiv (et al.)
Diabetes and the Skin
Pages 883-898
Mestdagh, Justine (et al.)
Foot Complications
Pages 899-918
Harkless, Lawrence B. (et al.)
Diabetes and Cancer
Pages 919-937
Krajewska (Wojciechowska), Joanna (et al.)
Diabetes in Children and Adolescents
Pages 941-966
Miranda Lora, América Liliana (et al.)
Pregnancy: Pregestational and Gestational Management
Pages 967-976
García-Argueta, María Isabel (et al.)
The Elderly with Diabetes
Pages 977-989
Valencia-Rodrigo, Willy Marcos
The Artificial Pancreas
Pages 993-998
Ginsberg, Barry H. (et al.)
Unproven Therapies for Diabetes
Pages 999-1013
Kesavadev, Jothydev (et al.)
-
Progesterone: Functions, Uses & Research Insights
La comanda in aproximativ 4 saptamani58000lei 550.00 lei -
57800lei 560.00 lei
Description:
In a single, convenient volume, Pediatric Endocrinology offers complete coverage of all aspects of basic science and clinical practice, ideal for both pediatricians and endocrinologists. Pediatric endocrinology expert Dr. Mark Sperling teams up with world-renowned authors to bring you up to date with the latest key developments in every area of the field, providing invaluable guidance on how your clinical decision making will be affected by today?s technological and scientific advances. The user-friendly text is enhanced by all-new online access to the complete contents of the book and more.
"Inclusion of clinical vignettes and supported by ExpertConsult access makes the text almost as good as face-to-face teaching." Reviewed by: Neel Kamal on behalf of BACCH Newsletter, March 2015
Features:
Determine the best possible course for every patient with easy-to-follow algorithms in every clinical chapter.
New To This Edition:
Stay up to date with today’s hottest topics, including neonatal diabetes mellitus, Type II childhood diabetes, molecular endocrinology, and genetics.
Explore the impact of today’s advances and challenges, including explosive growth in molecular biology, sophisticated imaging techniques, and an increase in both pediatric diabetes and obesity.
NEW! Access the fully searchable contents of the book and new self-assessment questions online at Expert Consult.
Quickly access the information you need with a new, streamlined organization (Concepts, Endocrine Disorders of the Newborn, Endocrine Disorders of Childhood and Adolescence, and Laboratory Tests and Imaging).
Table Of Contents:
Section I: Principles and Methods of Pediatric Endocrinology
Chapter 1. Overview and Principles of Pediatric Endocrinology
Chapter 2. Molecular Endocrinology and Endocrine Genetics
Chapter 3. Receptor Transduction Pathways Mediating Hormone Action
Chapter 4. Laboratory Methods in Pediatric Endocrinology
Section II: Endocrine Disorders in the Neonate
Chapter 5. Ambiguous Genitalia
Chapter 6. Hypoglycemia in the Newborn and Infant
Chapter 7. Disorders of the Thyroid in the Newborn and Infant
Chapter 8. Disorders of Calcium and Phosphorus Homeostasis in the Newborn and Infant
Chapter 9. Neonatal Diabetes Mellitus
Section III: Endocrine Disorders in Children and Adolescents
Chapter 10. Disorders of Growth Hormone/Insulin-Like Growth Factor Secretion and Action
Chapter 11. Disorders of the Posterior Pituitary
Chapter 12. Thyroid Disorders in Children and Adolescents
Chapter 13. Adrenal Cortex and Its Disorders
Chapter 14. Pheochromocytoma and Multiple Endocrine Neoplasia Syndromes
Chapter 15. Puberty and Its Disorders in the Female
Chapter 16. Turner Syndrome
Chapter 17. Puberty and Its Disorders in the Male
Chapter 18. Disorders of Mineral Homeostasis in Children and Adolescents
Chapter 19. Diabetes Mellitus
Chapter 20. Autoimmune Polyglandular Syndromes
Chapter 21. Hypoglycemia in the Toddler and Child
Chapter 22. Obesity, Metabolic Syndrome and Disorders of Energy Balance
Chapter 23. Lipid Disorders in Children and Adolescents
-
Obesity and Diabetes: New Surgical and Nonsurgical Approaches
La comanda in aproximativ 4 saptamani67400lei 580.00 leiThis timely and clinically oriented book uniquely addresses the entire spectrum of treatment for severe obesity and diabetes. It thoroughly examines all aspects from robotic surgery to cell therapy, from the latest antidiabetic drugs to endoscopic procedures and devices, from appetite-inhibiting signals and nutrients to gastric arterial embolization. It offers objective and authoritative information for practicing professionals; not only are successful interventions discussed and updated, but cutting-edge and experimental pathways are also anticipated.
Obesity is the foremost nutritional challenge worldwide. Its companion is type-2 diabetes, the most prevalent metabolic disease. Together they represent the diabesity epidemic, which is draining resources, overwhelming healthcare facilities, and impacting life expectancy and quality of life everywhere. No country has been spared, and most medical specialties have been affected. Many books focus on the surgical options for obesity and diabetes, namely bariatric and metabolic operations. Information on the clinical and pharmacological treatment is also available, conveyed by standard texts on internal medicine and endocrinology. Yet endoscopic maneuvers and prostheses, cell therapy for diabetes, and other innovative approaches are hard to come by, as conventional texts overlook such therapies. This timely publication bridges the gaps between all different therapeutic options, also covering advances in the conservative, surgical and parasurgical domains.
This book will appeal to seasoned specialists, students and healthcare professionals in training alike.
-
64500lei 600.00 lei
Description:
An ideal resource for both pediatricians and endocrinologists, Sperling’s Pediatric Endocrinology, 5th Edition, brings you fully up to date with accelerating research; new discoveries in metabolic, biochemical and molecular mechanisms; and the resulting advances in today’s clinical care. The editorial team of world-renowned pediatric endocrinologists led by Dr. Mark Sperling, as well as expert contributing authors, cover comprehensive and current aspects of both basic science and clinical practice. Whether you’re preparing for certification or have extensive clinical experience, this detailed, authoritative reference helps you increase your knowledge and determine the best possible course for every patient.
Key Features:
Delivers trusted guidance in every area of the field: including Endocrine Disorders of the Newborn, Endocrine Disorders of Childhood and Adolescence, and Laboratory Tests.
Features new topics such as transgender issues in children and adolescents and endocrinology of pregnancy, the fetus and the placenta.
Offers expert coverage of hot topics such as disorders of sexual development, molecular basis of endocrine disorders, hypoglycemia in newborns and infants; neonatal and other monogenic forms of diabetes; Type I and Type II diabetes and their treatment with new insulins together with the progress in an artificial pancreas and new medications for T2DM in adolescents; the obesity epidemic and role of bariatric surgery; and advances toward personalized medicine.
Includes easy-to-follow algorithms and numerous quick-reference tables and boxes in every clinical chapter, plus interactive questions online for self-assessment.
Offers state-of-the-art information and fresh perspectives from new and award-winning authors in such areas as disorders of growth, multiple endocrine tumors, and puberty and its disorders in girls and boys.
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Table Of Contents:
SECTION I Principles and Methods of Pediatric Endocrinology, 1
1. Overview and Principles of Pediatric Endocrinology, 1
Mark A. Sperling
2. Molecular Endocrinology, Endocrine Genetics, and Precision Medicine, 9
Ram K. Menon, Massimo Trucco, Joseph A. Majzoub, Constantine A. Stratakis
3. Receptor Transduction Pathways Mediating Hormone Action, 30
Bassil Kublaoui, Michael A. Levine
4. Endocrinology Laboratory Testing, 86
Jon NakamotoSECTION II Endocrine Disorders in the Neonate, 106
5. Fetal-Maternal Endocrinology and Parturition, 106
Sam Mesiano, Helen N. Jones, Heide Aungst, Tani Malhotra, Louis J. Muglia
6. Ambiguous Genitalia, 123
Selma Feldman Witchel, Peter A. Lee
7. Hypoglycemia in the Newborn and Infant, 175
Diva D. De Leon, Paul Thornton, Charles A. Stanley, Mark A. Sperling
8. Disorders of the Thyroid in the Newborn and Infant, 202
Johnny Deladoey, Julia Elisabeth von Oettingen, Guy Van Vliet
9. Disorders of Mineral Metabolism: Normal Homeostasis, 220
Allen W. Root
10. Monogenic Diabetes Mellitus: Neonatal Diabetes and Maturity-Onset Diabetes of the Young, 279
Siri Atma W. Greeley*, Mary K. McCauley*, Louis H. Philipson, Mark A. Sperling
*Authors contributed equally to this chapterSECTION III Childhood and Adolescent Endocrinology, 299
11. Disorders of Childhood Growth, 299
Alexander A.L. Jorge, Adda Grimberg, Mehul T. Dattani, Jeffrey Baron
12. Disorders of the Posterior Pituitary, 357
Abhinash Srivatsa, Joseph A. Majzoub
13. Thyroid Disorders in Children and Adolescents, 395
Scott Rivkees, Andrew J. Bauer
14. The Adrenal Cortex and Its Disorders, 425
Walter L. Miller, Christa E. Flück, David T. Breault, Brian J. Feldman
15. Pheochromocytoma/Paraganglioma, Medullary Thyroid Carcinoma, and Hereditary Endocrine Neoplasia Syndromes, 491
Steven G. Waguespack, Lauren Fishbein
16. Puberty in the Female and Its Disorders, 528
Robert L. Rosenfield, David W. Cooke, Sally Radovick
17. Turner Syndrome, 627
Philippe Backeljauw, Steven D. Chernausek, Claus Højbjerg Gravholt, Paul Kruszka
18. Puberty and Its Disorders in the Male, 661
Mark R. Palmert, Yee-Ming Chan, Leo Dunkel
19. Care of Transgender/Gender Nonconforming Youth, 695
Stephen M. Rosenthal, Amy B. Wisniewski
20. Disorders of Mineral Metabolism II. Abnormalities of Mineral Homeostasis in the Newborn, Infant, Child, and Adolescent, 705
Allen W. Root, Michael A. Levine
21. Diabetes Mellitus, 814
Mark A. Sperling, Joseph I. Wolfsdorf, Ram K. Menon, William V. Tamborlane, David Maahs, Tadej Battelino, Moshe Phillip
22. Autoimmune Polyglandular Syndromes, 884
Bimota Nambam, Michael J. Haller, William E. Winter, Desmond Schatz
23. Hypoglycemia in the Toddler and Child, 904
Joseph I. Wolfsdorf, Charles A. Stanley
24. Obesity, Metabolic Syndrome and Disorders of Energy Balance, 939
Joan C. Han, Ram Weiss
25. Lipid Disorders in Children and Adolescents, 1004
Stephen R. Daniels, Sarah C. CouchIndex, 1022
Interactive questions for self-assessment can be found in the e-book; see inside front cover for details.
-
Atlas of the Diabetic Foot
La comanda in aproximativ 4 saptamani69000lei 600.00 leiDESCRIPTION
The revised and updated third edition of the essential guide to the diagnosis and treatment of the diabetic foot
The revised third edition of the Atlas of the Diabetic Foot is an updated guide to the information needed for the prevention and treatment of diabetic foot problems with the aim of reducing amputations. In addition to offering the theoretical knowledge, the book is filled with more than 500 color photos from real-life cases. The cases explore a wide-variety of foot issues and the text includes information about differential diagnosis and treatment. The authors—noted experts in the field—describe the epidemiology, pathophysiology and classification of diabetic foot ulcers. In addition, the book highlights the diagnosis of the main risk factors for the diabetic foot, namely diabetic neuropathy, peripheral arterial disease and the anatomic deformities of the lower extremities.
The updated third edition, include 5 videos that clearly demonstrate the methods of examination for diabetic neuropathy and peripheral arterial disease. The text includes methods of callus removal and debridement as well as offloading. In addition, it contains information on how a total contact cast is constructed. This essential resource:
· Contains a full color presentation of diabetic foot cases
· Explains the prevention and treatment of diabetic foot problems in a revised and updated edition
· Includes a larger format that allows for a better quality images
· Offers a companion website with high-resolution digital files of photographs of the case studies presented
· Presents a multidisciplinary approach appropriate for a wide audience foot and diabetic professionals
Written for diabetes specialists, endocrinologists and diabetic nurse specialists, podiatrists and podiatry nurse specialists, Atlas of the Diabetic Foot offers the information needed to help with the prevention, diagnosis and management of the diabetic foot.
TABLE OF CONTENTS
Preface to the Third Edition vii
Preface to the Second Edition ix
Preface to the First Edition xi
Acknowledgements xiii
About the Companion Website xv
1 Introduction 1
2 Diabetic Neuropathy 11
3 Anatomic Risk Factors for Diabetic Foot Ulceration 23
4 Other Foot-Related Risk Factors 49
5 Skin and Systemic Diseases with Manifestations in the Feet 63
6 Neuropathic Ulcers 75
7 Peripheral Vascular Disease 91
8 Ischemic and Neuro-Ischemic Ulcers and Gangrene 107
9 Heel Ulcers 135
10 Charcot Foot 147
11 Infections 169
12 Methods of Prevention 197
13 Methods of Ulcer Healing 205
14 Amputations 229
Appendix 237
Index 239
-
Handbook of Diagnostic Endocrinology
La comanda in aproximativ 4 saptamani68700lei 615.00 leiDescription
The clinical laboratory plays a critical role in the diagnosis and management of endocrine and related metabolic disorders, which are leading causes of morbidity and mortality in children and adults. The Handbook of Diagnostic Endocrinology, Third Edition, provides a ready reference for the evaluation, diagnosis, and monitoring of such disorders. This revision incorporates translational medicine, connecting what clinicians need to know with those in research providing a clinical context to which they can relate their molecular findings. This book solves the needs of clinicians and researchers by bringing together in one book endocrinology at the molecular and clinical levels. As the intricacies of intracellular signaling have become better understood, states of hormone resistance are now increasingly recognized. The most common endocrinopathy in westernized countries, the metabolic syndrome, results, to a large extent, from insulin resistance. The complexity of the circulating forms of various hormones are acknowledged in this revision.
Key Features
Each chapter focuses on the biochemical tests that are required, either in the basal state or following provocation or suppression, to assist in the diagnosis of the various disorders
Describes proper sample collection and relevant interpretations of laboratory tests
Contains essential molecular biology and incorporates it with the clinical information
Includes the discovery of new diagnostic and treatment methods
Readership
Clinical chemists, chemical pathologists, endocrinologists, and senior medical technologists to aid them in the investigation of endocrine and metabolic disorders
Table of Contents
Maximizing the value of laboratory tests
Raffick A.R. Bowen, Roger L. Bertholf and Brett Holmquist
2. Laboratory investigation of disorders of the pituitary gland
Verena Gounden, Charlotte C. Ellberg and Ishwarlal Jialal
3. Thyroid disease and laboratory assessment
Sridevi Devaraj and Emily Garnett
4. Disorders of the adrenal gland
Roger L. Bertholf
5. Endocrine disorders of the reproductive system
Angela M. Ferguson and Mark A. Cervinski
6. Gastroenteropancreatic tumors
Neeraj Ramarishnan, Seong Hyun Ahn and Ishwarlal Jialal
7. Evaluation of hypoglycemia
William E. Winter and Neil S. Harris
8. Evaluation of hyperglycemia
William E. Winter, David L. Pittman, Sridevi Devaraj, Danni Li and Neil S. Harris
9. Lipoproteins
Anna Wolska and Alan T. Remaley
10. Disorders of calcium metabolism
William E. Winter and Neil S. Harris
11. Laboratory evaluation of endocrine hypertension
William E. Winter and Neil S. Harris
12. Malignancy-associated endocrine disorders
Lori J. Sokoll and Daniel W. Chan
13. Laboratory assessment of acquired immunodeficiency syndrome endocrinopathies
Verena Gounden and Manisha Chandalia
14. Laboratory evaluation of short stature in children
William E. Winter
15. Pregnancy and the fetus
K. Aaron Geno, Mark A. Cervinski and Robert D. Nerenz
16. Disorders of sexual development
William E. Winter, Paul Hiers and Dina N. Greene
17. Transgender endocrinology
Dina N. Greene, Tamar Reisman and Zil Goldstein
18. The endocrinology of aging
Daniel T. Holmes and Gregory Kline -
86600lei 695.00 lei
Childhood obesity has reached epidemic proportions in the United States and continues to increase in prevalence in almost all countries in which it has been studied, including developed and developing countries around the globe. The causes of obesity are complex and multi-factorial. Childhood obesity becomes a life-long problem in most cases and is associated with long term chronic disease risk for a variety of diseases including type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, as well as psychosocial as issues and obesity seems to affect almost every organ system in the body.
In recent years there has been tremendous progress in the understanding of this problem and in strategies for prevention and treatment in the pediatric years. Childhood Obesity: Causes, Consequences, and Intervention Approaches presents current reviews on the complex problem of obesity from the multi-level causes throughout early life before adulthood and the implications for this for long-term disease risk. It reviews numerous types of strategies that have been used to address this issue from conventional clinical management to global policy strategies attempting to modify the global landscape of food, nutrition, and physical activity. Each chapter is written by a global authority in his or her respective field with a focus on reviewing the current status and recent developments.
The book features information on contributing factors to obesity, including developmental origins, social/family, birth cohort studies, influence of ethnicity, and global perspectives. It takes a life-course approach to the subject matter and includes exhaustive treatment of contributing factors to childhood obesity, such as assessment, environmental factors, nutrition and dietary factors, host factors, interventions and treatment, consequences, and further action for future prevention. This broad range of topics relevant to the rapidly changing field of childhood obesity is suitable for students, health care professionals, physicians,
-
The Endometrial Factor: A Reproductive Precision Medicine Approach
La comanda in aproximativ 4 saptamani86600lei 695.00 leiAt the dawn of precision medicine, there is a new opportunity for novel approaches to understand, diagnose and treat endometrial disorders that affect fertility, reproductive outcomes, and women’s health more broadly. Herein, the editors have assembled critically evaluated state-of-the-art chapters presenting basic and clinical knowledge about the human endometrium that impacts or will impact clinical practice. All clinicians and researchers in Reproductive Medicine will find this book useful as a reference and a valuable tool for continued advancement in the understanding and management of the "endometrial factor".
-
Medical Management of Thyroid Disease, Third Edition
La comanda in aproximativ 4 saptamani86600lei 695.00 leiThe Third Edition of Medical Management of Thyroid Disease provides the most up-to-date practical guidance for the diagnosis and management of common and uncommon thyroid diseases. It reflects the advancement in guidelines and research for thyroid cancer, nodules and hypothyroidism; all presented in an accessible format with more illustrations and algorithms for management. The contributions of internationally renowned endocrinologists present the clinical aspects from the world’s perspective.
Key Features
• Completely revised and updated
• Reorganized with more algorithms for quick reference and enhanced usability
• Edited by internationally renowned physicians in the field
• Authoritative, comprehensive and yet easily digestible
-
Pediatric Endocrinology and Inborn Errors of Metabolism, Second Edition
La comanda in aproximativ 4 saptamani82600lei 715.00 leiThe acclaimed clinical guide to managing both pediatric endocrine disorders and inborn errors of metabolism
No other text so skillfully blends the disciplines of endocrinology and inborn metabolic disorders into one clinically focused, highly visual resource as Pediatric Endocrinology and Inborn Errors of Metabolism.
In this practical, user-friendly tutorial, a team of international contributors delivers the latest information and clinical insights clinicians need to confidently diagnose and manage pediatric patients. This full-color resource guides readers through the etiology, pathophysiology, presenting signs and symptoms, diagnostic laboratory examinations, and treatments regimens of each disorder. Pediatric Endocrinology and Inborn Errors of Metabolism successfully balances authority and comprehensiveness with a strong clinical, practical approach that delivers an unmatched integrated discussion of the fields.
• Full-color presentation with numerous photos, illustrations, diagnostic algorithms, tables, and text boxes that summarize key concepts and assist in the decision-making process
• At-a-Glance feature beginning each disease-based chapter summarizes all the clinical information you need to differentiate between disorder sub-types in one easy-to-find place
• Complete and detailed information on all laboratory and radiographic testing used to diagnose disorders in both disciplines
-
Endocrinology in Clinical Practice, Second Edition
La comanda in aproximativ 4 saptamani92400lei 740.00 leiFeatures:
Provides a cutting-edge, problem-orientated approach to the management of clinical problems in endocrinology
Presents complete updates of existing chapters and new research data, diagnostic techniques, treatment options, and safety concerns
Discusses neuroendocrine disease and examines strides made by the identification of aryl hydrocarbon receptorinteracting protein mutations
Reviews changes in diagnostic imaging
Explores the rapidly increasing incidence of neuroendocrine tumors and their management
Reviews the endocrinology of aging
Includes protocols for pituitary function testing
Summary:
Endocrinology is a complex specialty that spans a wide range of diseases, disorders, and conditions. The field is now moving toward an increasingly personalized approach to patient management, with a greater focus on mechanisms of disease and biomarkers. Written by internationally renowned specialists, the second edition of Endocrinology in Clinical Practice provides a cutting-edge, problem-orientated approach to the management of clinical problems in endocrinology.
Highlights of the new edition include:
An overview of neuroendocrine disease
Strides made by the identification of aryl hydrocarbon receptorinteracting protein mutations in patients with familial isolated pituitary adenomas
The diverse roles of IGF-I
Changes in diagnostic imaging and the increasing use of positron emission tomography
The rapidly increasing incidence of neuroendocrine tumors and their management
Hereditary primary hyperparathyroidism and multiple endocrine neoplasia
Mechanistic and genomic advances related to disorders of calcium regulation and infertility
The endocrinology of aging
Protocols for pituitary function testing With complete updates to existing chapters, the second edition also presents new research data, diagnostic techniques, treatment options, and safety concerns related to existing therapies. This edition offers current guidance and scientifically focused information relevant to a range of clinical problems, making it an essential reference for practicing endocrinologists and specialist clinicians. -
Endocrine and Metabolic Medical Emergencies: A Clinician's Guide
by Glenn MatfinLa comanda in aproximativ 4 saptamani90000lei 800.00 leiThe Essential Guide to Recognizing and Treating Acute Endocrine and Metabolic Illness
Endocrinology covers some of the most common conditions and serious public health challenges facing medicine today, and endocrine and metabolic emergencies constitute a large proportion of the clinical workload. Endocrine and Metabolic Medical Emergencies: A Clinicians Guide provides a singular reference to help endocrinologists, acute and general medicine clinicians, hospitalists and critical care physicians, and general practitioners recognize the symptoms of endocrine emergencies and provide the highest standards of care. Already the definitive and most comprehensive guide to endocrine emergency care, this new second edition: provides acute care guidance for a range of both common and unusual endocrine emergencies; details the effects of acute medical and critical illness on metabolic and endocrine systems, and their impacts on endocrine investigations; discusses special patient populations, including the impacts of aging, pregnancy, transplantation, late-effects, perioperative, inherited metabolic disorders and HIV/AIDS on presentation and management; and features detailed coverage of disorders by system, as well as, metabolic bone diseases, neuroendocrine tumors, and more.
Packed with case studies, images, and chapters written by distinguished authors, this guide is designed for both quick reference and study. Coverage includes the presentation, diagnosis, management, and treatment of endocrine and metabolic disorders in an acute care setting, as well as the most up-to-date guidance on issues including clinical lipidology, glucose, sodium, calcium and phosphate, and more.
Blending the latest science with clinical and practical advice, this invaluable resource helps clinicians stay up to date with the fields relevant body of knowledge while providing the practical, clinical insight they need in order to provide their patients with the utmost level of care. -
87000lei 800.00 lei
Presents comprehensive coverage of the many microvascular complications of diabetes
Diabetes remains one of the main causes, in the western world, of legal blindness, end stage renal disease, and amputation, despite the implementation of tight glycemic control and the great progress in the management and care of our patients. This book provides a useful and handy tool to professionals and students in the field of diabetes and its microvascular complications by integrating information from clinical settings as well as from the frontlines of diabetic research. It provides readers with up-to-date diagnostic criteria, classifications, and therapeutic approaches. and recent discoveries on mechanisms of disease, experimental therapeutic agents, and biomarkers of disease.
Written by top experts in the field, Microvascular Disease in Diabetes offers in-depth chapters covering pathophysiology; the genetics of diabetic microvascular disease; and the epigenetics of diabetic microvascular disease. It then provides sections featuring both clinical and research information on diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, and diabetic foot. It also looks at coronary microvascular dysfunction and cerebral microvascular disease.
· Integrates new and accessible material on diabetic microvascular comorbidities
· Covers all relevant microvascular systems
· Provides a much-needed resource synthesizing research and clinical applications to treating microvascular complications of diabetes
· Presents current diagnostic criteria, classifications, and therapeutic approaches, as well as recent discoveries on the mechanisms of disease, experimental therapeutic agents, and biomarkers of disease
Assembled in an easily consultable manner, Microvascular Disease in Diabetes is an excellent text for investigators, clinicians, and students looking to improve their understanding of diabetic complications.
ABOUT THE AUTHOR
FRANCESCO TECILAZICH, MD, PhD, is a physician and scientist in the Endocrinology and Metabolic Diseases department of the Ospedale San Raffaele—Vita Salute San Raffaele University in Milan, Italy.
TABLE OF CONTENTS
Foreword to: Microvascular Disease in Diabetes xv
Editor Biography xvii
List of Contributors xix
1 Introduction 1
Andrea Giustina and Stefano FraraReferences 3
2 Pathophysiology 5
Francesco TecilazichIntroduction 5
Anatomo-Physiology of Microvessels 5
Regulation of Microvascular Tone 6
Endothelial-Dependent Vasodilation 6
Endothelial-Independent Vasodilation 6
Nerve Axon Reflex (NARV) 7
Myogenic Response 7
Functional Hyperemia 7
Venoarteriolar Response (VAR) 8
Structural Changes in the Microcirculation 8
Functional Changes in the Microcirculation 8
Endothelial Dysfunction 8
VSMC Dysfunction 9
NARV Impairment 9
Defective Myogenic Response 10
Reduced Functional Hyperemia 10
Endothelial Dysfunction 11
Role of the Immune System and Leukostasis 11
Role of Hyperglycemia 12
AGEs 12
Polyol Pathway 12
Oxidative Stress 13
PKC 13
Transforming Growth Factor (TGF)-β 14
Hexosamine Pathway 14
PARP 14
ET-1 14
Vasoconstrictor Prostanoid Synthesis 15
Role of Insulin Resistance 15
Role of Inflammation 15
References 16
3 Genetics of Diabetic Microvascular Disease 23
Niina Sandholm and Carol ForsblomIntroduction 23
Genetics of DKD 23
Heritability of DKD 23
Candidate Genes for DKD 24
Linkage Studies for DKD 25
Genome-Wide Association Studies on DKD 25
Sequencing Efforts for DKD 29
Genetics of Diabetic Retinopathy 30
Heritability of Diabetic Retinopathy 30
Candidate Genes for Diabetic Retinopathy 30
Linkage Studies for Diabetic Retinopathy 31
GWAS on Diabetic Retinopathy 31
Sequencing Efforts for Diabetic Retinopathy 33
Genetics of Diabetic Neuropathy 33
Heritability of Diabetic Neuropathy 33
Candidate Genes for Diabetic Neuropathy 33
GWASs on Diabetic Neuropathy 34
Future Directions 34
Larger Studies are Needed 34
How to Define the Phenotype? 35
Variability in the Phenotypic Definitions 35
Criteria for Controls 36
Do Genetics of Microvascular Complications in T1D and T2D Differ? 36
Low-Frequency and Rare Variants May Affect Diabetic Complications 36
Sequencing of Rare and Low-Frequency Variants 36
Linkage Analysis with GWAS Data 37
Genetics May Reveal Biology and Infer Causality 37
Conclusions 37
References 37
4 Epigenetics of Diabetic Microvascular Disease 45
Luciano PirolaDiabetic Complications Include Microvascular and Macrovascular Injury 45
The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study in Type 1 Diabetic Patients, and the UKPDS Study in Type 2 Diabetic Patients, Support the Existence of the Hyperglycemic Memory Phenomenon 46
DCCT/EDIC Study 46
The UKPDS Study 46
Models of Hyperglycemic Memory 47
Animal Models 47
Cell Culture Models 48
The “Epigenetic Code” 48
DNA Methylation 49
Histone Methylation in Models of Hyperglycemic Variability 49
Epigenetic Changes in Microvascular Models of Glycemic Memory 50
MiRNAs Contribute to the Control of Glucose Homeostasis and are Dysregulated in Diabetes 52
Future Prospects 52
References 54
5 Diabetic Retinopathy – Clinical 59
Francesco Bandello, Rosangela Lattanzio, Alessandro Marchese, and Emanuela AragonaIntroduction 59
Epidemiology 60
Screening 60
Risk Factors 61
Clinical Patterns 61
Non-Proliferative Diabetic Retinopathy (NPDR) 61
Clinical Findings 62
Diagnostic Tools 64
Treatment Strategies 65
Proliferative Diabetic Retinopathy (PDR) 65
Clinical Findings 65
Diagnostic Tools 67
Treatment Strategies 67
Diabetic Macular Edema (DME) 69
Classification 70
Clinical Findings 71
Diagnostic Tools 71
Treatment Strategies 71
Conclusions 73
References 74
6 Diabetic Retinopathy – Research 79
Gopalan GnanaguruRetina and Induction of Hyperglycemia 79
Hyperglycemia and Retinal Microvasculature 80
Hyperglycemia and Reactive Gliosis 80
Hyperglycemia and Neurodegeneration 81
Hyperglycemia and Inflammation 81
References 82
7 Diabetic Nephropathy – Clinical 85
Gianpaolo ZerbiniEpidemiology 85
Natural History 86
Stages of DN 86
Morphologic Changes 87
Pathophysiology 88
Clinical Course 89
Treatment 90
Primary Prevention 90
Secondary Prevention 91
Tertiary Prevention 91
Perspectives 91
References 92
8 Diabetic Nephropathy – Research 97
Silvia Maestroni and Gianpaolo ZerbiniEssential Hypertension and DN 97
Role of Genetics in the Pathogenesis of DN 99
Polyol Pathway and Non-Enzymatic Glycation 100
Environment 100
Perspectives 101
Sodium–Glucose Cotransporter-2 (SGLT2) and DN 101
B7-1 and DN 101
Animal Models 102
DN in Induced Model of Type 1 Diabetes Mellitus (T1DM) 102
DN in Spontaneous Model of T1DM 103
Ins2Akita Mice 103
Non-Obese Diabetic (NOD) Mice 104
OVE26 Friend leukemia virus B (FVB) Mice 104
DN in Spontaneous Models of T2DM 105
db/db Mice 105
References 105
9 Diabetic Neuropathy – Clinical 111
Christopher H. GibbonsIntroduction 111
Classification of Diabetic Neuropathies 111
Distal Symmetric Polyneuropathy (DSPN) 112
Diagnosis 113
Management 113
Small Fiber Neuropathy 114
Diagnosis 115
Management 115
Autonomic Neuropathy 116
Diagnosis 117
Management 117
Treatment-Induced Neuropathy of Diabetes (TIND) 119
Diagnosis 119
Management 120
Diabetic Radiculoplexopathy 120
Diagnosis 120
Management 121
Mononeuropathies 121
Diagnosis 121
Management 121
Cranial Neuropathies 121
Diagnosis 121
Management 122
Screening for Neuropathy 122
Summary of Management of Diabetic Neuropathy 122
References 123
10 Diabetic Neuropathy – Research 129
Krish Chandrasekaran, Lindsay A. Zilliox, and James W. RussellBasic and Translational Research in Diabetic Neuropathy 129
Animal Models of Diabetic Neuropathy 129
Basic Pathophysiology of Diabetic Neuropathy 131
Changes in Redox Potential 131
Role of Mitochondrial Dysfunction in Diabetic Neuropathy 133
Protein Kinase C (PKC) and Neuropathy 137
Advanced Glycation End Products 137
Modifying Molecular Chaperones 138
Inflammation and Neuropathy 138
TGF-β and Neuropathy 138
Metabotropic Glutamate Receptors (mGluRs) and Oxidative Injury 139
Growth Factors and Diabetes 139
Clinical Research in Diabetic Neuropathy 140
Treatment of Hypertension 141
Improved Glycemic Control 141
Diet and Lifestyle Interventions 142
Alpha-Lipoic Acid 144
Benfotiamine and Neuropathy 145
Treatment of Neuropathic Pain 145
Acknowledgments 146
References 147
11 Diabetic Foot – Clinical 157
Cristian NicolettiIntroduction and Size of the Problem 157
Pathogenesis of Diabetic Foot Complications 158
Neuropathy 158
Peripheral Vascular Disease 158
Other Risk Factors 159
Prevention 159
Treatment 160
Treatment of Neuropathic Diabetic Foot Ulcers: Offloading 160
Treatment of PAD: Revascularization 161
Diabetic Foot Infections (DFIs) 163
Introduction 163
Diagnosis 163
Treatment 164
Wound Healing 166
Debridement 166
Dressings 167
Topical Negative Pressure Wound Therapy (NPWT) 167
Other Topical Treatments 167
References 167
12 Diabetic Foot – Research 173
Georgios Theocharidis and Aristidis VevesIntroduction 173
Anatomy of the Skin and Microcirculation 174
Structural Changes in the Microcirculation 174
Functional Changes in the Microcirculation 175
Functional Changes in the Diabetic Foot 176
Vasodilation 176
Endothelium-Dependent Vasodilation 177
Endothelium-Independent Vasodilation 178
Nerve Axon Reflex 179
Mechanisms of Endothelial Dysfunction 180
Endothelial Dysfunction and Hyperglycemia 180
Endothelial Dysfunction and Insulin Resistance 182
Endothelial Dysfunction and Inflammation 183
Pathophysiology of Diabetic Wound Healing 184
Hyperglycemia 184
Chronic Inflammation 184
Impaired Angiogenesis and Vasculogenesis 186
Hypoxia 186
Impaired Neuropeptide Signaling 186
Adjunctive Treatment Options 186
Bioengineered Skin Substitutes 187
Growth Factors 187
Hyperbaric Oxygen Therapy 188
Negative Pressure Wound Therapy 188
Electrical Stimulation and Shockwave Therapy 189
Future Therapeutic Perspectives 189
Gene Therapies 189
Stem Cell Therapies 189
Norleu3-Angiotensin-(1–7) 190
Neuropeptides 190
Cytokine Inhibition 190
Conclusion 191
References 191
13 Coronary Microvascular Dysfunction in Diabetes – Clinical and Research 201
Guglielmo Gallone, Francesco Moroni, and Marco MagnoniIntroduction 201
Clinical Classification and Mechanisms of CMD 202
CMD in Diabetic Patients 203
Clinical Assessment of CMD 205
Non-Invasive Imaging Technique for the Assessment of CMD 205
Transthoracic Doppler Evaluation 205
Contrast Echocardiography 206
Cardiovascular Magnetic Resonance (CMR) Imaging 206
Positron Emission Tomography (PET) 207
Invasive Techniques for the Evaluation of CBF 207
Indicator Dilution-Based Methods 207
Thermodilution 208
Gas Wash Out Method 208
Intracoronary Doppler Flow Wire 208
Treatment for CMD 210
The Effects of Glucose-Lowering Drugs on CMD 211
Future Perspectives for the Treatment of CMD in Diabetes 211
References 212
14 Cerebral Microvascular Disease in Diabetes – Clinical and Research 221
Eelco van Duinkerken and Richard G. IJzermanIntroduction 221
Postmortem Studies of the Brain in Diabetes 222
Cerebral Small Vessel Disease on MRI 223
MRI-Measured Cerebral Small Vessel Disease in Type 1 Diabetic Patients 224
White Matter Hyperintensities 224
Cerebral Microbleeds 226
Summary 226
Type 2 Diabetes and Cerebral Small Vessel Disease 227
Lacunar Infarcts 227
White Matter Hyperintensities 228
Cerebral Microbleeds 230
Synthesis 230
Clinical Impact of Cerebral Small Vessel Disease in Diabetes 231
Cognitive Functioning 231
Stroke 233
Dementia 234
The Influence of Microvascular Disease on the Structure and Functioning of the Diabetic Brain 235
Type 1 Diabetes 236
Type 2 Diabetes 237
Conclusions and Future Directions 239
References 240
Index 247
-
815.00 lei
An up-to-date reference for managing thyroid and parathyroid diseases
A highly illustrated, detailed and didactic text on medical and surgical aspects of thyroid and parathyroid diseases. -- Pediatric Endocrinology Reviews
The book is well illustrated...and serves as an up-to-date and comprehensive guide to the evaluation and treatment of those with thyroid and parathyroid disorders. It is well resourced and written with insight, and includes the newer surgical techniques, such as minimally invasive surgery and robotics. -- Journal of Laryngology & Otology
...an excellent foundation for understanding all aspects of thyroid and parathyroid disease. -- Head & Neck
Thyroid and Parathyroid Diseases, Second Edition, has been revised and updated to reflect recent advances in the medical and surgical management of thyroid and parathyroid diseases. This new edition serves as both a comprehensive guide to patient evaluation as well as an atlas of advanced surgical techniques for managing patients needing operative intervention. Separate chapters are devoted to minimally invasive techniques and remote access/robotic thyroidectomy techniques, both of which have enjoyed increased application throughout the world.
New in the second edition:
· A section on state-of-the-art, evidence-based management of challenging parathyroid conditions such as multiple endocrine neoplasia and renal hyperparathyroidism
· A more detailed discussion of thyroid cancer evaluation and staging
· A new chapter dedicated to parathyroid cancer
· Nearly 200 additional full-color illustrations
This new edition is a valuable resource for all surgeons, endocrinologists, and residents seeking to expand their knowledge of thyroid and parathyroid diseases, as well as seasoned clinicians who want to improve patient care and incorporate the latest surgical advancements into their practice.
-
Hypoparathyroidism
La comanda in aproximativ 4 saptamani840.00 lei- First textbook to be devoted entirely to hypoparathyroidism
- Provides essential, up-to-date information on the pathology, diagnosis, and treatment of hypoparathyroidism
- Covers a wide range of hypoparathyroid disorders Discusses novel replacement therapy with PTH 1-34 and 1-84
- Includes a chapter on surgical hypoparathyroidism
About this book
Hypoparathyroidism, a condition in which insufficient parathyroid hormone (PTH) is produced to maintain normocalcemia is associated with a variety of acute and chronic symptoms and complications due to hypocalcemia. Replacement therapy utilizing PTH has long been awaited, and this book is new and very timely as it coincides with the publication of results on the role of the PTH molecule in the pharmacological management of this disorder. This advance is sparking renewed interest in hypoparathyroidism, which is attributable to neck surgery in most cases and to inherited disorders in a minority.
Hypoparathyroidism has been written by acknowledged experts in the field and provides essential, up-to-date information on the pathology, diagnosis, and treatment of the condition. It opens by addressing in detail the anatomy and physiology of the parathyroids and describing the epidemiology and clinical presentation of hypoparathyroidism. The full range of hypoparathyroid disorders are then discussed, including the various genetic forms, postoperative hypoparathyroidism, and other forms of acquired hypoparathyroidism. Individual chapters focus on refractory disease, the impact of the condition on bone, and the management of acute hypocalcemia. Both conventional treatment for hypoparathyroidism and the novel replacement therapy with PTH peptides are then thoroughly examined. Pseudohypoparathyroidism is also extensively discussed, with information on the various forms, differential diagnosis, and genetic testing. This book will be of interest to all endocrinologists, and also to surgeons and internal medicine physicians.
Table of contents (38 chapters)
· The History: From Ivar Sandström to the Sequence of Parathyroid Hormone
Mannstadt, Michael (et al.)
Pages 3-10
· Embryology of the Parathyroid Glands
Manley, Nancy R.
Pages 11-18
· PTH and PTH-Related Peptides
Isaia, Giancarlo (et al.)
Pages 19-24
· PTH Assays and Their Clinical Significance
DAmour, Pierre
Pages 25-32
· Control of Parathyroid Hormone Secretion by Extracellular Ca
Brown, Edward M.
Pages 33-48
· Phosphate Control of PTH Secretion
Messa, Piergiorgio
Pages 49-59
· Role of Magnesium in Parathyroid Physiology
Steen, Oren (et al.)
Pages 61-67
· The PTH/Vitamin D/FGF23 Axis
Goltzman, David (et al.)
Pages 69-79
· The PTH Receptorsome and Transduction Pathways
Gardella, Thomas J.
Pages 81-87
· G Protein Gsα and
Bastepe, Murat
Pages 89-98
· Parathyroid Hormone Actions on Bone and Kidney
Pajevic, Paola Divieti (et al.)
Pages 99-109
· PTH and PTHrP: Nonclassical Targets
Cianferotti, Luisella
Pages 111-126
· In Vitro Cellular Models of Parathyroid Cells
Gomez, Ana Rita (et al.)
Pages 127-135
· Epidemiology of Hypoparathyroidism
Clarke, Bart L.
Pages 139-154
· Clinical Presentation of Hypoparathyroidism
Wheeler, Amber L. (et al.)
Pages 155-165
· Familial Isolated Hypoparathyroidism
Hendy, Geoffrey N. (et al.)
Pages 167-175
· Autoimmune Hypoparathyroidism
Kemp, E. Helen (et al.)
Pages 177-188
· DiGeorge Syndrome
Tarsitano, Marina (et al.)
Pages 189-197
· Hypoparathyroidism, Deafness, and Renal Anomaly Syndrome
Nesbit, M. Andrew
Pages 199-213
· Hypoparathyroidism, Dwarfism, Medullary Stenosis of Long Bones, and Eye Abnormalities (Kenny-Caffey Syndrome) and Hypoparathyroidism, Retardation, and Dysmorphism (Sanjad-Sakati) Syndrome
Hershkovitz, Eli (et al.)
Pages 215-224
· Hypoparathyroidism in Mitochondrial Disorders
Orsucci, Daniele (et al.)
Pages 225-230
· Postoperative Hypoparathyroidism
Tonelli, Francesco (et al.)
Pages 231-247
· Hypoparathyroidism During Pregnancy, Lactation, and Fetal/Neonatal Development
Kovacs, Christopher S.
Pages 249-269
· Rare Causes of Acquired Hypoparathyroidism
Wémeau, Jean-Louis
Pages 271-278
· Refractory Hypoparathyroidism
Masi, Laura
Pages 279-286
· Bone Histomorphometry in Hypoparathyroidism
Dempster, David W.
Pages 287-296
· Management of Acute Hypocalcemia
Cooper, Mark Stuart (et al.)
Pages 297-301
· Conventional Treatment of Chronic Hypoparathyroidism
Rejnmark, Lars
Pages 303-312
· Follow-up in Chronic Hypoparathyroidism
Mannstadt, Michael (et al.)
Pages 313-318
· Treatment of Hypoparathyroidism with Parathyroid Hormone 134
Winer, Karen K. (et al.)
Pages 319-331
· Replacement Therapy with PTH(184)
Rubin, Mishaela R. (et al.)
Pages 333-342
· Classification of Pseudohypoparathyroidism and Differential Diagnosis
Mantovani, Giovanna (et al.)
Pages 345-354
· Pseudohypoparathyroidism Type 1a, Pseudopseudohypoparathyroidism, and Albright Hereditary Osteodystrophy
Weinstein, Lee S.
Pages 355-362
· Pseudohypoparathyroidism Type Ib (PHP-Ib): PTH-Resistant Hypocalcemia and Hyperphosphatemia Due to Abnormal
Jüppner, Harald
Pages 363-372
· Genetic Testing in Pseudohypoparathyroidism
Linglart, Agnès (et al.)
Pages 373-388
· Blomstrands Chondrodysplasia
Giusti, Francesca (et al.)
Pages 389-395
· Hypoparathyroidism During Magnesium Deficiency or Excess
Rizzoli, René
Pages 397-403
· Advocacy and Hypoparathyroidism in the Twenty-First Century
Sanders, James E. (et al.)
Pages 407-414
- First textbook to be devoted entirely to hypoparathyroidism
-
Osteoporosis in Older Persons
La comanda in aproximativ 4 saptamani840.00 leiThis new edition includes the most up-to-date information about the pathophysiology and new therapeutic alternatives for osteoporosis of advanced age. It is written by investigators (clinicians and basic scientists) in the field of aging bone research.
It was just recently that a new syndrome, osteoporosis of advanced age, was recognized as a new entity with its own pathophysiology and potential treatments. Unfortunately, and despite the fact that hip fractures are mostly a consequence of this process, and apart from the first edition of this book, there are few publications about this subject.
The first edition of this book demonstrated that there is a need to understand the particular features of osteoporosis in older persons, which is the main aim of this book. The institutions where the authors are affiliated are highly recognized as the main centers in aging bone research. As an innovation, the second edition includes some aspects of muscle and bone interaction focusing of the impact of age-related muscle loss (sarcopenia) on the pathogenesis of falls and fractures in older persons. As in the previous edition, this book is expected to be the reference guide for geriatricians, gerontologists, and bone biologists as well as medical trainees in order to understand the mechanisms of senile osteoporosis with a practical approach to the treatment of its consequences. -
Williams Textbook of Endocrinology, 14th Edition
La comanda in aproximativ 4 saptamani1,02000lei 855.00 leiExpertly bridging the gap between basic science and clinical information, Williams Textbook of Endocrinology, 14th Edition, brings together an outstanding collection of world-renowned authors to provide authoritative discussions of the full spectrum of adult and pediatric endocrine system disorders. New chapters and significant revisions throughout keep you up to date with recent advances in medications, therapies, clinical trials, and more. This essential reference is a must-have resource for endocrinologists, endocrine surgeons, gynecologists, internists, pediatricians, and other clinicians who need current, comprehensive coverage of this multifaceted field.
Table Of Contents:
Section I: HORMONES AND HORMONE ACTION
1. Principles of Endocrinology
2. Principles of Hormone Action
3. Genetics of Endocrinology
4. Laboratory Techniques for Recognition of Endocrine Disorders
5. The Global Burden of Endocrine Disease
6. Navigating Through Clinical Practice Guidelines in Endocrinology
Section II: HYPOTHALAMUS AND PITUITARY
7. Neuroendocrinology
8. Pituitary Physiology and Diagnostic Evaluation
9. Pituitary Masses and Tumors
10. Posterior Pituitary
Section III: THYROID
11. Thyroid Physiology and Diagnostic Evaluation
12. Hyperthyroid Disorders
13. Hypothyroidism and Thyroiditis
14. Nontoxic Diffuse Goiter, Nodular Thyroid Disorders, and Thyroid Malignancies
Section IV: ADRENAL CORTEX AND ENDOCRINE HYPERTENSION
15. The Adrenal Cortex
16. Endocrine Hypertension
Section V: SEXUAL DEVELOPMENT AND FUNCTION
17. Physiology and Pathology of the Female Reproductive Axis
18. Hormonal Contraception
19. Testicular Disorders
20. Sexual Dysfunction in Men and Women
21. Transgender Endocrinology
Section VI: ENDOCRINOLOGY AND THE LIFE SPAN
Section VI A: Maternal-Fetal
22. Endocrine Changes in Pregnancy
23. Endocrinology of Fetal Development
Section VI B: Childhood
24. Disorders of Sex Development
25. Normal and Aberrant Growth in Children
26. Physiology and Disorders of Puberty
Section VI C: Adult
27. Hormones and Athletic Performance
28. Endocrinology and Aging
Section VII: MINERAL METABOLISM
29. Hormones and Disorders of Mineral Metabolism
30. Osteoporosis: Basic and Clinical Aspects
31. Rickets and Osteomalacia
32. Kidney Stones
Section VIII: DISORDERS OF CARBOHYDRATE AND FAT METABOLISM
33. Physiology of Insulin Secretion
34. Pathophysiology of Type 2 Diabetes Mellitus
35. Therapeutics of Type 2 Diabetes Mellitus
36. Type 1 Diabetes Mellitus
37. Complications of Diabetes Mellitus
38. Hypoglycemia
39. Neuroendocrine Control of Energy Stores
40. Obesity
41. Disorders of Lipid Metabolism
Section IX: POLYENDOCRINE AND NEOPLASTIC DISORDERS
42. Multiple Endocrine Neoplasia
43. The Immunoendocrinopathy Syndromes
44. Endocrinology of HIV/AIDS
45. Neuroendocrine Tumors
46. Endocrinology of Cancer Survivors -
Management of Prader-Willi Syndrome
La comanda in aproximativ 4 saptamani1,00000lei 900.00 leiManagement of Prader-Willi Syndrome brings together the contributions of professionals with considerable expertise in diagnosis and management of PWS. Clinical, social, family, and community issues are explored and management strategies identified. The text presents historical, medical, and genetic information to orient the reader. The major portion deals with pragmatic guidelines, rather than research and diagnosis, and is directed to health and educational specialists in academic, clinical, and community settings. This manual is endorsed by The Prader-Willi Syndrome Association, which is recognized world-wide.
-
Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease
La comanda in aproximativ 4 saptamani1,01100lei 900.00 leiThe field of microbial endocrinology is expressly devoted to understanding the mechanisms by which the microbiota (bacteria within the microbiome) interact with the host (“us”). This interaction is a two-way street and the driving force that governs these interactions are the neuroendocrine products of both the host and the microbiota. Chapters include neuroendocrine hormone-induced changes in gene expression and microbial endocrinology and probiotics. This is the first in a series of books dedicated to understanding how bi-directional communication between host and bacteria represents the cutting edge of translational medical research, and hopefully identifies new ways to understand the mechanisms that determine health and disease.
-
1,23500lei 1100.00 lei
This book brings together recognized experts in the field to describe their current techniques for the surgical treatment of diseased thyroid, parathyroid, and adrenal glands, as well as neuroendocrine tumors of small bowel, pancreas, liver, and skin. For each procedure, indications, operative steps, potential pitfalls and complications, and postoperative management are presented. The clear descriptions coupled with informative and beautiful illustrations will give the reader new perspectives and insights into the anatomy and conduct of these procedures. Endocrine surgery has been an area of special interest to surgeons for well over a century, while the increasing incidence of neuroendocrine tumors has more recently led to greater attention to these neoplasms. Significant advances have been made in a variety of areas, the most recent being the introduction of minimally invasive methods of removing diseased glands, and the improved understanding of the natural history of neuroendocrine tumors.
-
Kidney Transplantation, Bioengineering, and Regeneration, Kidney Transplantation in the Regenerative Medicine Era
La comanda in aproximativ 4 saptamani1,33800lei 1150.00 leiDescription:
Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement.
In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney.
- Focuses on the synergy between renal organ transplantation and regenerative medicine, highlighting the advances within transplantation, bioengineering, regeneration, and repair
- Educates the transplant community on important regenerative medicine research pertinent to kidney transplantation
- Develops a shared language for clinicians, surgeons, and basic researchers to reach across the fields of transplantation and regenerative medicine, and facilitate more productive investigation and research
- Catalogs the technologies being developed and methods being implemented to bioengineer or regenerate kidneys to restore function
· Introduction
· Part I: Kidney Transplantation
· Section I: Epidemiology of Kidney Disease and Transplantation
· Chapter 1. Epidemiology of End-Stage Renal Failure: The Burden of Kidney Diseases to Global Health
· Chapter 2. Transplant Programs Worldwide and the Spanish Miracle
· Section II: Donor Selection and Allocation
· Chapter 3. The Deceased Kidney Donor
· Chapter 4. The Living Donor
· Chapter 5. Criteria for Kidney Allocation in the United States
· Chapter 6. Strategies to Increase the Donor Pool
· Section III: Kidney Preservation and Transplant Procedures
· Chapter 7. Kidney Preservation
· Chapter 8. Ex-vivo Normothermic Perfusion in Renal Transplantation
· Chapter 9. Kidney Transplant Recipient Surgery
· Chapter 10. Robotic-Assisted Kidney Transplantation
· Chapter 11. Orthotopic Kidney Transplantation
· Chapter 12. Kidney Transplantation Combined With Other Organs
· Chapter 13. Pediatric Renal Transplantation
· Section IV: Kidney Recipient: Before and Peritransplant
· Chapter 14. Indications for Renal Transplantation: Evaluation of Transplant Candidates
· Abstract
· Chapter 15. Early Postoperative ICU Care of the Kidney Transplant Recipient
· Chapter 16. Approaches to Minimize Delayed Graft Function in Renal Transplantation
· Section V: Transplantation Immunology and Immunomodulation
· Chapter 17. Histocompatibility Testing in the Transplant Setting
· Chapter 18. The Immune Response to the Allograft
· Chapter 19. Induction Immunosuppression in Kidney Transplantation
· Chapter 20. Maintenance Immunosuppression in Kidney Transplantation
· Chapter 21. Novel Drugs in Kidney Transplantation
· Chapter 22. Hematopoietic Stem Cell Transplantation for Induction of Allograft Tolerance
· Chapter 23. Regulatory T Cell Therapy in Transplantation
· Chapter 24. Mesenchymal Stromal Cells to Improve Solid Organ Transplant Outcome:
· Chapter 25. Renal Transplantation Across HLA and ABO Barriers
· Section VI: Graft Monitoring Tools
· Chapter 26. Pathology of the Renal Allograft
· Chapter 27. Imaging-Based Monitoring of the Renal Graft
· Chapter 28. Immune Monitoring in Kidney Transplantation
· Chapter 29. Renal Function Measurements
· Chapter 30. Pharmacokinetics and Genomics of Immunosuppressive Drugs
· Chapter 31. Gene Expression Technology Applied to Kidney Transplantation
· Section VII: Early Posttransplant Immune Events
· Chapter 32. Acute Cellular Rejection
· Chapter 33. Acute Antibody-Mediated Rejection
· Section VIII: Early and Late Complications
· Chapter 34. Vascular Complications in Renal Transplantation
· Chapter 35. Infections in Kidney Transplant Recipients
· Chapter 36. Metabolic Disorders Following Kidney Transplantation
· Chapter 37. Cancer After Kidney Transplantation
· Chapter 38. Cardiovascular Disease and Renal Transplantation
· Chapter 39. Graft and Patient Survival
· Chapter 40. Urological Complications of the Renal Graft
· Chapter 41. Impact of De Novo Donor-specific Alloantibody in Primary Renal Allografts
· Chapter 42. De Novo and Recurrence of Renal Disease
· Section X: Transplant Issues in Specific Patient Groups
· Chapter 43. Kidney Transplantation in the Elderly
· Chapter 44. Dual Kidney Transplantation
· Chapter 45. Kidney Transplantation in the Diabetic Patient
· Chapter 46. Kidney Transplantation in the Hepatitis C Infected Recipient
· Chapter 47. Pregnancy After Kidney Transplantation
· Chapter 48. Nutrition of the Kidney Transplant Recipients
· Section XI: Ethics and Costs
· Chapter 49. Kidney Transplantation in Developing Countries
· Chapter 50. Health-Related Quality of Life Outcomes After Kidney Transplantation
· Chapter 51. Costs of Kidney Transplantation
· Section XII: Unmet Needs
· Chapter 52. Kidney Transplantation: Have the Promises Been Kept and Needs Met
· Chapter 53. Innovations in Kidney Transplant Research
· Part II: Kidney Bioengineering and Regeneration
· Section I: Introduction
· Chapter 54. Converging Organ Transplantation Towards Regenerative Medicine
· Chapter 55. A Systems Engineering Approach to Restoring Kidney Structure and Function
· Abstract
· Section II: Kidney Development
· Chapter 56. Kidney Development in the Mammal
· Chapter 57. Renal Branching Morphogenesis
· Section III: Bioengineering
· Chapter 58. Principles of Stem Cell Biology Applied to the Kidney
· Chapter 59. Extracellular Matrix Biology Applied to the Kidney
· Chapter 60. Interplay Between Growth Factor Receptors, Small GTPases, and Mechanical Stress in the Maintenance of Kidney Glomerular Homeostasis
· Chapter 61. Bioengineering Approach to Immunomodulation
· Chapter 62. Principles of Organ Bioengineering
· Chapter 63. Recellularization of Kidney Scaffold With Stem Cells
· Section IV: Bioreactors and Biomaterials
· Chapter 64. Bioreactors for Cell Culture Systems and Organ Bioengineering
· Chapter 65. Synthetic Biomaterial for Regenerative Medicine Applications
· Chapter 66. Immune Responses to Biomaterials Used in Renal Engineering
· Section V: Regeneration
· Chapter 67. Regeneration of Kidney From Human Reprogrammed Stem Cells
· Chapter 68. Bioprinting Complex 3D Tissue and Organs
· Chapter 69. Principles of Kidney Regeneration
· Chapter 70. Markers of Repair and Regeneration in the Marginal Kidney
· Chapter 71. Nephron Repair in Mammals and Fish
· Chapter 72. Imaging of Glomerular Regeneration
· Chapter 73. Reversibility of Renal Fibrosis
· Chapter 74. Pharmacological Induction of Kidney Regeneration
· Chapter 75. Developmental Approaches to Kidney Regeneration
· Section VI: Adult Cells for Regeneration
· Chapter 76. Nephron Progenitors
· Chapter 77. Urine Progenitor Cells for Potential Application in Renal Tissue Repair
· Chapter 78. Endothelial Progenitor Cells in Kidney Disease
· Section VII: Cell Therapy For Renal Tissue Repair
· Chapter 79. Mesenchymal Stromal Cells for Acute Renal Injury
· Chapter 80. Amniotic Fluid Cells: Kidney Injury and Regeneration
· Chapter 81. Renal Cells From Spermatogonial Germline Stem Cells for Protection Against Kidney Injury
· Chapter 82. Kidney-on-a-Chip: Technologies for Studying Pharmacological and Therapeutic Approaches to Kidney Repair
· Chapter 83. Renal Replacement Devices
· Chapter 84. Xenotransplantation and Kidney Regenerative Technology
· Chapter 85. Embryonic Organoid Transplantation
· Chapter 86. Lineage Reprogramming Toward Kidney Regeneration
· Chapter 87. Regenerating Kidney Structure and Function: An Industry Perspective
- Focuses on the synergy between renal organ transplantation and regenerative medicine, highlighting the advances within transplantation, bioengineering, regeneration, and repair
-
Endocrine Surgery, Second Edition
La comanda in aproximativ 4 saptamani1,44500lei 1160.00 leiThe second edition of Endocrine Surgery is a comprehensive update of the previous edition published in 2003. Edited by three leading authorities in the field of surgical endocrinology, the book encompasses the clinical, imaging, nuclear, molecular, technological and evidence-based principles that are applied in the diagnosis and treatment of all categories of endocrine tumors. Authored by experts from across the globe, this textbook reflects the best international clinical practice and also provides an outstanding educational resource.
With full color illustrations throughout, the new edition emphasizes contemporary approaches in successive stages including: pituitary endocrine tumors; pathology and pathophysiology of pulmonary neuroendocrine cells; surgery of endocrine tumors of the lungs and thymus; robotic endocrine surgery; molecular testing of thyroid nodules; pediatric surgery for neuroblastoma and ganglioneuroma; multiple endocrine neoplasia; retroperitoneoscopic adrenalectomy; radionuclide imaging of carcinoid tumors, pancreas and adrenals; serotonin-induced cardiac valvular disease and surgical treatment; multimodal management of primary and metastatic neuroendocrine tumors; pathophysiology and surgery of Type II diabetes; post-bariatric surgery hyperinsulinemic hypoglycemia; and surgical management of metabolic syndrome.
Endocrine Surgery 2e provides the clinician with a definitive resource to reach curative outcomes in the treatment of patients with endocrine pituitary, thyroid, and parathyroid entities. Further coverage of broncho-pulmonary, adrenal, pancreatic, and intestinal neoplasia is also included, making this the definitive textbook on the subject.
Demetrius Pertsemlidis, MD FACS The Bradley H. Jack Professor of Surgery, Icahn School of Medicine at Mount Sinai, New York, USA
William B. Inabnet III, MD FACS Professor of Surgery and Chief, Division of Metabolic, Endocrine and Minimally Invasive Surgery, Icahn School of Medicine at Mount Sinai, New York, USA
Michel Gagner, M.D. FRCSC, FACS, FASMBS
Clinical Professor of surgery, Herbert Wertheim School of Medicine, Florida International
-
Brook's Clinical Pediatric Endocrinology, 7th Edition
La comanda in aproximativ 4 saptamani1,30000lei 1200.00 leiThe seventh edition of Brook's Clinical Pediatric Endocrinology has been compiled by an experienced editorial team and internationally renowned contributors; it presents basic science and clinical management of endocrine disorders for all involved in the care of children and adolescents. It provides treatments for a variety of hormonal diseases, including diabetes and hypoglycaemia, growth problems, thyroid disease and disorders of puberty, sexual differentiation, calcium metabolism, steroid metabolism and hypopituitarism.
ABOUT THE AUTHOR
MEHUL T. DATTANI, MD, FRCP, FRCPCH, is Professor of Pediatric Endocrinology at the UCL GOS Institute of Child Health and Head of Pediatric Endocrinology at Great Ormond Street Hospital for Children, University College London Hospitals, and Institute of Child Health. He is currently the Chair of the Programme Organising Committee of the European Society for Paediatric Endocrinology.
CHARLES G.D. BROOK, MA, MD, FRCP, was the first Professor of Pediatric Endocrinology in the UK and the founder of the London Centre for Pediatric Endocrinology at Great Ormond Street Hospital and University College London Hospitals. He was the recipient of the Andrea Prader Prize in 2000, the most prestigious award for outstanding leadership and research in the gift of the European Society for Paediatric Endocrinology.
TABLE OF CONTENTS
List of Contributors xix
Preface xxiii
About the Companion Website xxv
1 Genetics and Genomics 1
Anu Bashamboo and Ken McElreaveyIntroduction 1
Basic Concepts in Human Genetics and Genomics 1
Classes of RNA Molecules and their Functions 4
Gene Mutations and Inheritance 7
Human Populations and Genetic Variation 12
Epigenetics 14
Advances in Genomic Analysis 15
Establishing Variant Causality 19
The Age of Precision Medicine 24
Clinical Guidelines 24
Acknowledgments 25
Glossary of Terms 25
Further Reading 29
2 Measuring Hormones 31
Gerhard BinderIntroduction 31
Hormone Assays 31
Assay Validity 33
Technical Pitfalls When Measuring Hormones 36
Clinical Assay Validity 38
Stimulation Tests, Suppression Tests and Profiles 42
Optimal Clinical Use of Hormone Tests 44
Acknowledgements 44
References 44
3 Fetal Endocrinology 47
Harshini Katugampola, Evelien F. Gevers, and Mehul T. DattaniIntroduction 48
Transplacental Passage of Hormones 48
Development of Fetal Endocrine Systems 50
Neutralization of Hormone Activity in the Fetus 82
Plasticity of Fetal Endocrine Systems 84
Fetal Adaptations for Transition to Extrauterine Life 85
Frontiers in Fetal and Neonatal Endocrinology 89
References 90
4 Disorders of Sex Development 105
Martine Cools and Birgit KöhlerNormal Sex Development 105
Terminology 106
Causes of DSD 107
Impaired Gonadal Development 108
Disturbances of Testicular Hormone Production or Action 113
Virilization of an XX Individual 116
Management of DSD 118
Clinical Management 122
Other Examples of XY DSD 126
Future Perspectives 127
References 127
Weblinks 131
5 Disorders of Hypothalamo‐Pituitary Axis 133
Hoong‐Wei Gan, Kyriaki‐Sandy Alatzoglou, and Mehul T. DattaniIntroduction 133
The Hypothalamo‐Pituitary Neuroendocrine Axis 134
Hypothalamo‐Pituitary Development 134
Congenital Disorders of Hypothalamo‐Pituitary Development 144
Acquired Disorders of Hypothalamo‐Pituitary Dysfunction 155
Investigation of Hypopituitarism 172
Management of Hypopituitarism 173
Conclusion 174
References 174
6 Disorders of Growth 199
P.G. Murray and P.E. ClaytonNormal Growth 200
Short Stature 205
Acquired GH Deficiency 211
Disorders of GH Action and GH Sensitivity (Primary IGF‐I Deficiency) 213
Growth Disorders not Related to the GH‐IGF Axis 216
Syndromes Associated with Short Stature 219
Idiopathic Short Stature 225
Skeletal Dysplasias 227
Tall Stature 229
References 233
7 Puberty and Its Disorders 235
Sasha R. Howard, Nicolas de Roux, Juliane Leger, Jean‐Claude Carel, and Leo DunkelNormal Puberty 235
Precocious Puberty 256
Delayed Puberty 265
Conclusions 283
References 284
8 The Thyroid Gland 289
Catherine Peters and Nadia SchoenmakersSection 1: Development of the Thyroid Axis 289
Section 2: Clinical Thyroid Disorders 301
Section 3: Diagnostic Pitfalls 315
References 320
Weblinks 334
9 The Adrenal Cortex and Its Disorders 335
Claire R. Hughes, Elim Man, and John C. AchermannIntroduction 335
Development, Function and Regulation of the Adrenal Gland 336
Adrenal Insufficiency (AI) 353
Adrenal Excess 393
Education, Support and Long‐Term Care 401
10 The Parathyroid and Disorders of Calcium and Bone Metabolism 409
Jeremy Allgrove and Moira CheungIntroduction 409
Physiology of Calcium and Bone Metabolism 409
Physiology of Bone Metabolism 421
Interactions between Calciotropic Agents 425
Fetal and Neonatal Calcium Metabolism 425
Post‐Neonatal Calcium, Phosphate and Magnesium Metabolism and the Calcium Cascade 426
Clinical Conditions 426
Drugs Used in the Treatment of Disorders of Calcium and Bone Metabolism 467
Summary 470
References 472
Weblinks 479
11 Polyglandular Autoimmune Syndromes 481
Catherine J. Owen, Mario Abinun, Simon H.S. Pearce, and Tim D. CheethamIntroduction 481
Autoimmune Polyendocrinopathy Syndrome Type 1 (APS1) 483
Autoimmune Polyendocrinopathy Syndrome Type 2 and Associated Disorders 494
Other Single Gene Disorders Associated with Immune Dysregulation and Autoimmune Endocrinopathies 499
Conclusion 502
References 502
12 Endocrine Neoplasia 507
Constantine A. Stratakis and Emmanouil SaloustrosThyroid Neoplasia: Nodules and Cancer 507
Paragangliomas and Phaeochromocytomas 511
Adrenocortical Cancers 521
Tumours of the Ovary 524
Tumours of the Testes 528
References 530
13 Endocrine Late Effects of Cancer Treatments 533
Wassim Chemaitilly and Melissa M. HudsonPrevalence and Risk Factors for Endocrine Late Effects 538
Diagnosis and Management of Common Endocrine Late Effects 546
Summary 550
References 550
Weblinks 552
14 Disorders of Water Balance 553
Natascia Di Iorgi, Flavia Napoli, Giovanni Morana, and Mohamad MaghnieRegulation of Water Balance 554
Diabetes Insipidus (DI) 558
Central Diabetes Insipidus and Adipsia 572
Primary Polydipsia 572
Nephrogenic Diabetes Insipidus 573
The Syndrome of Inappropriate Antidiuretic Hormone Secretion 573
Management of Central Diabetes Insipidus 573
Treatment of Nephrogenic Diabetes Insipidus 574
Treatment of Inappropriate Antidiuretic Hormone Secretion 574
Challenges 575
Conclusions 575
Clinical Guidelines 575
References 576
15 Diabetes Mellitus 583
G.R. Ambler, F.J. Cameron, K. Joshi, and D.K. WherrettType 1 Diabetes 583
Type 2 Diabetes 626
Cystic Fibrosis‐Related Diabetes 637
Monogenic Forms of Diabetes 639
Rare Forms of Diabetes 647
Living with Diabetes 648
References 649
16 Disorders Associated with Hypoglycaemia in Children 671
Pratik Shah, Emma Footit, and Ritika KapoorIntroduction 671
Physiology of Blood Glucose Control 672
Role of Gut Hormones in Glucose Homeostasis 673
Metabolic Adaptation to Birth 673
Metabolic Adaptation to Feeding and Fasting 674
The Regulation of Insulin Secretion and Role of KATP Channels 675
Definition of Hypoglycaemia 676
Aetiology and Clinical Approach to Hypoglycaemia 678
Investigations for Hypoglycaemia 680
Emergency Management of Hypoglycaemia 682
Causes of Hypoglycaemia 682
17 Obesity 701
Wieland KiessIntroduction 701
Definitions, Differential Diagnosis, Assessments and Measurements 701
Aetiology of Obesity 703
Common or Multifactorial Obesity and Fetal Programming 705
Neurobiology of Satiety and Hunger 705
Hedonistic Signals and Addiction 706
Behaviour, Hypothalamus and Obesogenic Environment 707
Biology of Adipose Tissue and Adipocytes 707
Microbiota 708
Endocrinology of Obesity 709
Epigenetics 709
Social Inheritance 709
Sociodemographics 710
Nutrition and Malnutrition 710
Physical Activity 711
Sedentary Behaviour 711
Endocrine‐Disrupting Chemicals and Toxicology 711
Media Use 712
Cultural Aspects 712
Evolution 712
Epidemiology 713
Developed Countries 713
Developing Countries 713
Co‐Morbidities and Consequences 713
Social Participation 718
Mortality 719
Health Economics 720
Treatments 720
Microbiota 723
Urban Living 724
Advertising Industries 724
Conclusions 725
Further Reading 726
Weblinks 728
18 Genetic Obesity Syndromes 729
Tinh‐Hai Collet and I. Sadaf FarooqiIntroduction 729
Genetic Contributors to Obesity: The Evidence 729
Genetic Obesity Syndromes: An Overview 730
Obesity with Developmental Delay 730
Obesity without Development Delay 732
Conclusions 734
References 734
Weblinks 736
19 Endocrine Care During Adolescence into Young Adulthood 737
Helena GleesonIntroduction 737
Adolescence and Young Adulthood 737
Exploratory and Health‐Related Behaviours 740
Addressing Adherence 743
Young People with Endocrine Conditions 744
Conclusion 750
References 751
Index 757
-
International Textbook of Diabetes Mellitus, 2 Volume Set 4th Edition
La comanda in aproximativ 4 saptamani1,50000lei 1300.00 leiThe International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.
-
1,51800lei 1400.00 lei
Through ten outstanding editions, Werner & Ingbar's The Thyroid: A Fundamental and Clinical Text has been the go-to reference for the most comprehensive coverage of the thyroid, including anatomy, development, biochemistry, physiology, pathophysiology, and treatment of all thyroid disorders. Now in full color throughout, the 11th Edition of this award-winning text remains the clinician’s preferred source of authoritative information on the thyroid—an essential resource for all endocrinologists and thyroid surgeons.
- Includes thorough updates and new content throughout the text, especially on thyroid cytopathology, thyroid imaging, and targeted therapy of thyroid cancer as well as a new full-color format.
- Covers all aspects of the thyroid, including thyroid hormone synthesis and secretion, thyroid function, and disorders such as thyrotoxicosis, hypothyroidism, and cancer.
- Discusses surgical management of thyroid cancer, thyroid disruptors, thyroid hormone analogs, thyroid dysfunction’s effects on other organ systems, the aging thyroid, subclinical hypothyroidism and hyperthyroidism, and thyroid disease in pregnancy.
- Features insights from international experts, including new editor Dr. Peter Kopp of Northwestern University’s Feinberg School of Medicine.
Enrich Your Ebook Reading Experience
- Read directly on your preferred device(s), such as computer, tablet, or smartphone.
- Easily convert to audiobook, powering your content with natural language text-to-speech.
Table of Contents:Cover
Title Page
Copyright
Dedication
Contributors
Preface to the Eleventh Edition
Preface to the First Edition
Contents
Section I: The Normal Thyroid
A. History, Development, Anatomy
Chapter 1: The heritage of the thyroid: A brief history
GOITER, CRETINISM, AND THE THYROID GLAND
GOITER AND IODINE
THYROTOXICOSIS
HYPOTHYROIDISM AND THE RECOGNITION OF THYROID FUNCTION
THERAPY OF HYPOTHYROIDISM
DISCOVERY OF THE ACTIVE PRINCIPLE AND THERAPY OF HYPOTHYROIDISM
SCREENING AND THERAPY OF CONGENITAL HYPOTHYROIDISM
DISCOVERY OF CURRENT CONCEPTS OF THYROID HORMONE SYNTHESIS, TRANSPORT, AND ACTION
AUTOIMMUNE ETIOLOGY OF GRAVES DISEASE AND HASHIMOTO THYROIDITIS
THYROID CANCER
OUTLOOK
REFERENCES
Chapter 2: Development and anatomy of the hypothalamic–pituitary–thyroid axis
THE HYPOTHALAMIC–PITUITARY AXIS
SIGNALING AND TRANSCRIPTIONAL MECHANISMS INVOLVED IN HYPOTHALAMUS ORGANOGENESIS
SIGNALING AND TRANSCRIPTIONAL MECHANISMS INVOLVED IN PITUITARY ORGANOGENESIS
THE THYROID GLAND
THYROID BUD FORMATION
THYROID MIGRATION
THYROID FOLLICULOGENESIS
DIFFERENTIATED THYROID FOLLICULAR CELLS
HISTOLOGY AND STRUCTURE
THYROID TRANSCRIPTION FACTORS
OTHER TRANSCRIPTION FACTORS INVOLVED IN THYROID DEVELOPMENT
IN VITRO GENERATION OF THYROID CELLS FROM PLURIPOTENT STEM CELLS
MODELING THYROID BY TRANSCRIPTION FACTORS OVEREXPRESSION
MODELING THYROID BY CHEMICAL PATHWAYS MANIPULATIONS
CONCLUSIONS
ACKNOWLEDGMENTS
REFERENCES
B. Thyroid Hormone Synthesis and Secretion
Chapter 3: Thyroid hormone synthesis: Thyroid iodide transport
IDENTIFICATION BY FUNCTIONAL EXPRESSION OF THE CDNA ENCODING RAT NIS
THE NIS MOLECULE
ISOLATION OF THE CDNA ENCODING HUMAN NIS (hNIS) AND ELUCIDATION OF THE GENOMIC ORGANIZATION OF hNIS
NIS IN EXTRATHYROIDAL TISSUES
NIS MECHANISM AND STOICHIOMETRY
SUBSTRATE SPECIFICITY OF NIS
NIS TRANSPORTS THE ENVIRONMENTAL POLLUTANT ClO4− WITH A 1 Na+:1 ClO4− STOICHIOMETRY
IODIDE TRANSPORT DEFECT, A CONGENITAL CONDITION CAUSED BY MUTATIONS IN THE NIS (SLC5A5) GENE
NIS KO MICE, A USEFUL MODEL FOR STUDYING MULTIPLE RAMIFICATIONS OF HYPOTHYROIDISM
REGULATION OF NIS TRANSCRIPTION
REGULATION OF NIS IN THE THYROID BY TSH
REGULATION OF NIS BY I−
REGULATION OF NIS BY A K+ CHANNEL
NIS IN THYROID CANCER
I− EFFLUX
NIS IN BREAST CANCER
IMPACT OF NIS ON PUBLIC HEALTH
NIS GENE TRANSFER
CONCLUDING REMARKS AND AVENUES FOR FUTURE INVESTIGATION
REFERENCES
Chapter 4: Thyroid hormone synthesis
IODIDE UPTAKE INTO THE THYROID
THE GENE AND PROTEIN STRUCTURE OF THE SODIUM/IODIDE SYMPORTER
FUNCTIONAL CHARACTERIZATION OF THE SODIUM/IODIDE SYMPORTER
REGULATION OF IODIDE UPTAKE AND SODIUM/IODIDE SYMPORTER FUNCTION AND EXPRESSION
MUTATIONS IN THE SODIUM/IODIDE SYMPORTER GENE
IODIDE EFFLUX FROM THE THYROID
PENDRED SYNDROME AND PENDRIN (PDS/SLC26A4)
PROTEIN STRUCTURE OF PENDRIN
EXPRESSION AND REGULATION OF PENDRIN
FUNCTIONAL CHARACTERIZATION OF PENDRIN
GOITER AND THYROID DYSFUNCTION IN PENDRED SYNDROME
ANOCTAMIN
SLC26A7
THYROGLOBULIN
STRUCTURE OF THE THYROGLOBULIN GENE AND PROTEIN
MUTATIONS IN THE THYROGLOBULIN GENE
THYROID PEROXIDASE
THE GENE AND PROTEIN STRUCTURE OF THYROID PEROXIDASE
FUNCTIONAL CHARACTERIZATION OF THYROID PEROXIDASE
EXPRESSION AND REGULATION OF THYROID PEROXIDASE
MUTATIONS IN THYROID PEROXIDASE
THE HYDROGEN PEROXIDE–GENERATING SYSTEM
CLONING OF THE DUAL OXIDASE AND THE DUAL OXIDASE MATURATION FACTOR GENES
THE PROTEIN STRUCTURE OF DUAL OXIDASES AND THE DUAL OXIDASE MATURATION FACTORS
EXPRESSION AND REGULATION OF DUAL OXIDASES AND THE DUAL OXIDASE MATURATION FACTORS
MECHANISM OF HYDROGEN PEROXIDE GENERATION
REGULATION OF HYDROGEN PEROXIDE ACTIVITY
GENETIC DEFECTS IN HYDROGEN PEROXIDE GENERATION
IODINATION AND THYROID HORMONE SYNTHESIS
OXIDATION OF THYROID PEROXIDASE TO COMPOUND I AND COMPOUND II
OXIDATION OF IODIDE
IODINATION AND COUPLING OF TYROSYL RESIDUES
INHIBITION OF THYROID PEROXIDASE BY THIONAMIDE DRUGS
CELLULAR UPTAKE AND PROTEOLYSIS OF THYROGLOBULIN
SECRETION OF THYROID HORMONES
DEHALOGENATION OF MONOIODOTYROSINE AND DIIODOTYROSINE
IODOTYROSINE (IYD/DEHAL1) DEIODINASE GENE AND PROTEIN
DEHALOGENASE DEFICIENCY
REFERENCES
C. Peripheral Thyroid Hormone Binding and Metabolism
Chapter 5: Thyroid hormone transport proteins
EVOLUTIONARY CONSIDERATIONS
FUNCTIONS OF THBPs
CLINICAL CONSIDERATIONS
THYROID-BINDING GLOBULIN
STRUCTURE AND FUNCTION
PHYSIOLOGIC REGULATION OF TBG IN HUMANS
PATHOLOGY
HUMAN SERPINA7 GENE SEQUENCE VARIANTS AFFECTING TBG CONCENTRATION OR FUNCTION
TRANSTHYRETIN
STRUCTURE AND FUNCTION
PHYSIOLOGIC REGULATION OF TTR IN HUMANS
PATHOLOGY
HUMAN TTR GENE SEQUENCE VARIANTS AFFECTING TTR CONCENTRATION OR FUNCTION
DYSTRANSTHYRETINEMIC HYPERTHYROXINEMIA
ALBUMIN
STRUCTURE AND FUNCTION
PATHOPHYSIOLOGY
HUMAN ALB GENE VARIANTS AFFECTING ALB CONCENTRATION OR FUNCTION
p.Arg242His
OTHER SEQUENCE VARIANTS AT Arg242
p.Arg246Ile
T3 VARIANTS OF FDH
MINOR CARRIERS
CLINICAL IMPLICATIONS OF THBPs
REFERENCES
Chapter 6: Intracellular pathways of iodothyronine metabolism/implications of deiodination for thyroid hormone action
STRUCTURE OF THE DEIODINASES
TOPOLOGY AND SUBCELLULAR LOCALIZATION
STRUCTURE–FUNCTION RELATIONSHIPS OF DEIODINASES AND MECHANISM OF DEIODINATION
SPECIFIC PROPERTIES OF THE DEIODINASES
TYPE 1 DEIODINASE
TYPE 2 DEIODINASE
TYPE 3 DEIODINASE
NONDEIODINATIVE METABOLISM OF IODOTHYRONINES
PHYSIOLOGIC ROLES OF THE SELENODEIODINASES
DEIODINASES AND THE REGULATION OF T3 PRODUCTION
ADAPTATION TO HYPOTHYROIDISM
INTRACELLULAR TRIIODOTHYRONINE HOMEOSTASIS
DEIODINASES AND REGULATION OF THYROTROPIN SECRETION
DEIODINASES AND THE BIOLOGIC EFFECTS OF THYROID HORMONE
DEIODINASES AND THE CENTRAL NERVOUS SYSTEM
DEIODINASES AND THE SKELETON
DEIODINASES AND METABOLISM
DEVELOPMENTAL ROLES OF THE DEIODINASES
MATERNAL–FETAL PHYSIOLOGY
TRIIODOTHYRONINE MODULATION OF PLACENTAL THYROID HORMONE TRANSFER
D3 EXPRESSION AND THE REQUIREMENT FOR THYROXINE IN NORMAL PREGNANCY
THE DEIODINASES IN HUMAN PATHOPHYSIOLOGY
NONTHYROIDAL ILLNESS
CONSUMPTIVE HYPOTHYROIDISM
DEIODINASES IN CANCER
HYPERTHYROIDISM AND OVEREXPRESSION OF DEIODINASES
DEIODINASES IN THE ISCHEMIC HEART
DEIODINASES IN LUNG INJURY
CONCLUSION
ACKNOWLEDGMENT
REFERENCES
D. Thyroid Hormone Action
Chapter 7: Intracellular actions by thyroid hormones
THYROID HORMONE TRANSPORT AND METABOLISM
TR-DEPENDENT SIGNALING OF TH WITH DIRECT BINDING TO DNA (TYPE 1)
THYROID HORMONE RESPONSE ELEMENTS
TRANSCRIPTIONAL REGULATION BY TRs
THYROID HORMONE RECEPTOR–INTERACTING COREPRESSORS/BASAL REPRESSION
THYROID HORMONE RECEPTOR–INTERACTING COACTIVATORS/TRANSCRIPTIONAL ACTIVATION
NEGATIVE REGULATION BY TRs
POSTTRANSLATIONAL MODIFICATION OF TR
RESISTANCE TO TH
THYROID HORMONE RECEPTOR ISOFORM KNOCKOUT AND KNOCKIN MICE
TRANSCRIPTIONAL CASCADES
TR-DEPENDENT SIGNALING OF TH WITH INDIRECT BINDING TO DNA (TYPE 2)
TR-DEPENDENT SIGNALING OF TH WITHOUT DNA BINDING (TYPE 3)
TR-INDEPENDENT TH SIGNALING (TYPE IV)
TH ANALOGS, DISRUPTORS, AND METABOLITES
SUMMARY
REFERENCES
Chapter 8: Thyroid hormone structure–function relationships
THYROID HORMONE STRUCTURE, METABOLISM, AND ACTIVITY
TR ACTIVATION BY NATURAL AND SYNTHETIC AGONISTS
DEVELOPMENT OF SELECTIVE TR SUBTYPE AGONISTS
STRUCTURE–FUNCTION RELATIONSHIPS AT TR MUTANTS—THE ISSUE OF TH RESISTANCE
TR ANTAGONISM
THYROID HORMONE INTERACTIONS WITH ALTERNATE RECEPTORS AND BINDING PROTEINS
THYRONAMINES AND ANALOGS
CONCLUSION
REFERENCES
E. Factors That Control Thyroid Function
Chapter 9: Chemistry and biosynthesis of thyrotropin
CHEMISTRY
GENES ENCODING THE SUBUNITS OF THYROTROPIN
CHROMOSOME LOCALIZATION
STRUCTURE OF THE COMMON α-SUBUNIT GENE
STRUCTURE OF THE THYROTROPIN-β–SUBUNIT GENE
CENTRAL HYPOTHYROIDISM DUE TO THYROTROPIN-β–SUBUNIT GENE ABNORMALITIES
PRETRANSLATIONAL REGULATION OF THYROTROPIN BIOSYNTHESIS
NEGATIVE REGULATORS
POSITIVE REGULATORS
SUMMARY OF PRETRANSLATION REGULATION OF THE HUMAN COMMON α- AND TSH-β–SUBUNIT GENE EXPRESSION
POSTTRANSLATIONAL PROCESSING OF THYROTROPIN
IN VITRO TRANSLATION OF THYROTROPIN-β–SUBUNIT AND α-SUBUNIT MESSENGER RNA
BIOSYNTHESIS OF THYROTROPIN IN INTACT CELLS
PROCESSING OF HIGH-MANNOSE PRECURSOR OLIGOSACCHARIDES
TERMINAL SULFATION AND SIALYLATION OF COMPLEX OLIGOSACCHARIDES
DEVELOPMENTAL AND ENDOCRINE REGULATION OF THYROTROPIN GLYCOSYLATION
BIOACTIVITY AND METABOLIC CLEARANCE OF THYROTROPIN
THREE-DIMENSIONAL CONFORMATION OF THYROTROPIN
RECOMBINANT HUMAN THYROTROPIN
REFERENCES
Chapter 10: The thyrotropin receptor
THE STRUCTURE OF THE THYROTROPIN RECEPTOR
THE THYROTROPIN RECEPTOR GENE
RECOGNITION OF THE RECEPTOR BY THYROTROPIN
PROPOSED MECHANISM OF ACTIVATION OF THE RECEPTOR BY TSH
ACTIVATION BY THYROSTIMULIN
ACTIVATION BY CHORIONIC GONADOTROPIN
ACTIVATION BY THYROTROPIN-RECEPTOR ANTIBODIES
ACTIVATION BY LOW–MOLECULAR-WEIGHT DRUG-LIKE CHEMICALS
DOWNREGULATION OF THE THYROTROPIN RECEPTOR
REFERENCES
Chapter 11: Aging and the thyroid
CHANGES IN THYROID ANATOMY WITH AGE
PHYSIOLOGIC CHANGES IN THYROID FUNCTION WITH AGE
CHALLENGES IN THE DIAGNOSIS AND MANAGEMENT OF THYROID DYSFUNCTION WITH AGE
CHALLENGES IN THE DIAGNOSIS AND MANAGEMENT OF NODULAR DISEASE AND THYROID CANCER
SUMMARY
REFERENCES
Chapter 12: Effects of drugs on TSH secretion, thyroid hormones’ absorption, synthesis, metabolism, and action
INTRODUCTION
DRUGS THAT ALTER SERUM TSH LEVELS (FIG. 12-1, PANEL 1)
DOPAMINE/DOPAMINE AGONISTS AND ANTAGONISTS
SOMATOSTATIN AND SOMATOSTATIN ANALOGS
REXINOIDS
OTHER DRUGS THAT SUPPRESS TSH SECRETION
DRUGS THAT REDUCE THYROID HORMONE ABSORPTION
BILE ACID SEQUESTRANTS
FERROUS SULFATE
SUCRALFATE AND ALUMINUM-CONTAINING ANTACIDS
CALCIUM CARBONATE AND PHOSPHATE BINDERS
OTHER MEDICATIONS THAT MAY REDUCE T4 INTESTINAL ABSORPTION
DRUGS THAT REDUCE SYNTHESIS AND SECRETION OF THYROID HORMONES (FIG. 12-1, PANEL 2)
THIONAMIDES (ANTITHYROID DRUGS)
IONIC INHIBITORS (PERCHLORATE, THIOCYANATE; SEE Chapter 13 ON THYROID DISRUPTORS)
LITHIUM
DRUGS THAT ALTER THE METABOLISM OF THYROID HORMONES (FIGS. 12-1, PANEL 3 AND 12-2)
DRUGS THAT INDUCE CYP3a (PHENYTOIN, CARBAMAZEPINE, PHENOBARBITAL, RIFAMPIN, RITONAVIR, SERTRALINE)
DRUGS THAT INHIBIT THE DEIODINATION OF T4 AND T3
PROPYLTHIOURACIL
PROPRANOLOL AND NADOLOL
DRUGS THAT ALTER THE TRANSPORT OR ACTION OF THYROID HORMONES (FIG. 12-1, PANEL 3)
NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (SALICYLATES, SALSALATE, FENCLOFENAC)
FUROSEMIDE
HEPARIN AND FATTY ACIDS
ESTROGEN AND SELECTIVE ESTROGEN MODULATORS (SERM) (TAMOXIFEN, RALOXIFENE)
ANDROGENS
OTHER DRUGS ALTERING TBG LEVELS
DRUGS ACTING AT MULTIPLE SITES TO ALTER THYROID HORMONE HOMEOSTASIS
IODINATED RADIOGRAPHIC CONTRAST AGENTS
PHENYTOIN
AMIODARONE
GLUCOCORTICOIDS
CYTOKINES (INTERFERON, INTERLEUKIN, AND TUMOR NECROSIS FACTOR)
TYROSINE KINASE INHIBITORS
DRUGS ALTERING THYROID FUNCTION THROUGH ALTERATIONS IN IMMUNITY
IMMUNE RECONSTITUTION SYNDROME
ANTI-CD52 ANTIBODY ALEMTUZUMAB
CHECKPOINT INHIBITORS
REFERENCES
Chapter 13: Thyroid disruptors
INTRODUCTION
SUBSTANCES THAT INHIBIT THYROIDAL IODINE UPTAKE
PERCHLORATE
THIOCYANATE
NITRATE
COMPOUNDS WITH DIRECT ACTIONS ON THE THYROID HORMONE RECEPTOR
POLYCHLORINATED BIPHENYLS
POLYBROMINATED DIPHENYL ETHERS
BISPHENOL-A AND PHTHALATES
TRICLOSAN
COMPOUNDS THAT DISPLACE T4 FROM SERUM THYROID BINDING PROTEINS
PCBs AND PBDEs
COMPOUNDS THAT INHIBIT THYROPEROXIDASE ACTIVITY
ISOFLAVONES
COMPOUNDS THAT DECREASE T4 HALF-LIFE BY ACTIVATING HEPATIC ENZYMES
ORGANOCHLORINE PESTICIDES
DIOXINS AND FURANS
COMPOUNDS THAT INHIBIT DEIODINASE ACTIVITY
OTHER EXPOSURES
STYRENES
PERFLUORINATED AND GEN X COMPOUNDS
ORGANOPHOSPHATE PESTICIDES
SUNSCREENS
LEAD
SUMMARY
REFERENCES
Chapter 14: Nonthyroidal illness syndrome
INTRODUCTION
DESCRIPTION OF NTIS
CHANGES IN SERUM THYROID HORMONE AND THYROTROPIN CONCENTRATIONS
CHANGES IN THYROID HORMONE KINETICS
CHANGES IN THE HYPOTHALAMIC–PITUITARY–THYROID AXIS
CHANGES IN PERIPHERAL THYROID HORMONE METABOLISM
PATHOGENESIS OF NTIS
PATHOGENESIS OF CHANGES IN THE HYPOTHALAMIC–PITUITARY–THYROID AXIS
CHANGES IN HPT AXIS DURING FASTING
CHANGES IN HPT AXIS DURING ILLNESS
PATHOGENESIS OF CHANGES IN PERIPHERAL THYROID HORMONE METABOLISM
CHANGES IN SERUM IODOTHYRONINE–BINDING PROTEINS
CHANGES IN IODOTHYRONINE TRANSPORT INTO TISSUES
CHANGES IN IODOTHYRONINE DEIODINASES
CHANGES IN IODOTHYRONINE NUCLEAR RECEPTORS
CLINICAL RELEVANCE OF NTIS
PROGNOSTIC IMPORTANCE OF NTIS
DIAGNOSIS OF THYROID DISEASE IN NTIS
TREATMENT OF PATIENTS WITH NTIS
SPECIFIC TYPES OF NTIS
CHRONIC RENAL FAILURE
LIVER DISEASE
HUMAN IMMUNODEFICIENCY VIRUS INFECTION
PSYCHIATRIC DISEASE
CONCLUSION
REFERENCES
Chapter 15: Iodine deficiency and excess, endemic cretinism
INTRODUCTION
THE ECOLOGY OF IODINE
DIETARY SOURCES, ABSORPTION, AND METABOLISM OF IODINE
GOITROGENS
IODINE REQUIREMENTS
ADULTHOOD
PREGNANCY AND LACTATION
INFANCY AND CHILDHOOD
ASSESSMENT OF IODINE DEFICIENCY
URINARY IODINE CONCENTRATION
BREAST MILK IODINE CONCENTRATION
THYROID SIZE
THYROID-STIMULATING HORMONE AND THYROID HORMONES
THYROGLOBULIN
EFFECTS OF IODINE DEFICIENCY
THYROIDAL ADAPTATION TO IODINE DEFICIENCY
EFFECTS OF HYPOTHYROIDISM DUE TO IODINE DEFICIENCY ON THE DEVELOPING BRAIN
CRETINISM
THE BENEFITS OF CORRECTION OF IODINE DEFICIENCY
IODINE INTERVENTIONS IN SEVERELY DEFICIENT PREGNANT WOMEN
IODINE INTERVENTIONS IN MILD TO MODERATELY DEFICIENT PREGNANT WOMEN
INFANCY
CHILDHOOD
ADULTHOOD
THYROID CANCER
EPIDEMIOLOGY
TREATMENT AND PREVENTION
SALT FORTIFICATION WITH IODINE
IODINE SUPPLEMENTATION
EFFECTS OF EXCESS IODIDE
PHYSIOLOGIC RESPONSE TO EXCESS IODIDE
TOLERABLE UPPER LIMITS FOR IODINE INTAKE
MONITORING OF IODINE EXCESS IN POPULATIONS
SOURCES OF EXCESS IODIDE
IODINE-INDUCED HYPOTHYROIDISM OR GOITER IN THE ABSENCE OF APPARENT UNDERLYING THYROID DISEASE
IODINE AND THYROIDITIS
IODINE-INDUCED THYROTOXICOSIS
AMIODARONE-INDUCED THYROID DISEASE (SEE Chapter 11)
REFERENCES
Section II: Assessment of Thyroid Structure and Function
Chapter 16: Physical examination of the thyroid gland
HISTORY
PHYSICAL EXAMINATION
INSPECTION
PALPATION
FACING THE PATIENT
STANDING BEHIND THE PATIENT
AUSCULTATION
PALPATING LOBES AND EVALUATING THYROID SIZE
THYROID NODULES
HEMIAGENESIS
CONSISTENCY
PAIN/TENDERNESS
LYMPHADENOPATHY
DISTINGUISHING BENIGN FROM MALIGNANT DISEASE
REFERENCES
Chapter 17: Laboratory measurement of thyroid-related hormones, proteins, and autoantibodies in serum
INTRODUCTION
NOMENCLATURE FOR SENSITIVITY AND ASSESSMENT OF ASSAYS
FUNCTIONAL VERSUS ANALYTICAL SENSITIVITY OF ASSAYS
THYROID-STIMULATING HORMONE
METHODS FOR SERUM TSH MEASUREMENTS
REQUIREMENTS FOR SERUM TSH MEASUREMENTS
TSH ISOFORMS
INDICATIONS FOR TRH TESTING
TSH REFERENCE INTERVALS
THE CLINICAL UTILITY OF TSH MEASUREMENT
TSH AND THYROID FUNCTION ASSESSMENT IN PREGNANCY (SEE Chapter 66)
HOSPITALIZED PATIENTS
THYROID HORMONE MEASUREMENTS
SERUM TOTAL THYROID HORMONE (TT4 AND TT3) ASSAY METHODOLOGY
CLINICAL UTILITY OF TT4 AND TT3 MEASUREMENTS
TT4 AND TT3 REFERENCE INTERVALS
SERUM FREE THYROID HORMONE TESTS (FT4 AND FT3)
DIRECT FT4 AND FT3 METHODS
INDIRECT FT4 AND FT3 ESTIMATE TESTS
SERUM-FREE THYROXINE AND FREE TRIIODOTHYRONINE INDEXES
THYROID HORMONE–BINDING PROTEINS
FAMILIAL DYSALBUMINEMIC AND TRANSTHYRETIN-ASSOCIATED HYPERTHYROXINEMIAS
SERUM THYROGLOBULIN (Tg)
REQUIREMENTS FOR SERUM Tg METHODS
FACTORS THAT INFLUENCE CIRCULATING Tg CONCENTRATIONS
ANALYTICAL AND TECHNICAL CONSIDERATION
THYROID-SPECIFIC AUTOANTIBODIES
ANTI–TSH RECEPTOR AUTOANTIBODIES
ANTITHYROID PEROXIDASE AUTOANTIBODIES
ANTITHYROGLOBULIN AUTOANTIBODIES
INTERFERENCES WITH THYROID TEST OUTCOMES
INTERFERENCES WITH THYROID MEASUREMENT METHODOLOGIES
ASSAY INTERFERENCES
AUTOMATION OF THYROID TESTS
REFERENCES
Chapter 18: Nonisotopic thyroid imaging
INTRODUCTION
PLAIN RADIOGRAPHY
ULTRASONOGRAPHY
BASIC PHYSICS AND TECHNICAL PRINCIPLES (1)
CONDUCTING THE EXAMINATION
CLINICAL APPLICATIONS
DEVELOPMENTAL ABNORMALITIES
THE NORMAL THYROID GLAND
GOITER
DIFFUSE NONNEOPLASTIC THYROID DISEASES
NODULES AND MULTINODULAR GOITER
INTERVENTIONAL PROCEDURES
COMPUTED TOMOGRAPHY
BASIC PHYSICS PRINCIPLES (22)
THE NORMAL THYROID GLAND
DIFFUSE THYROID DISEASE
INCIDENTALOMAS
CT IN LARGE BENIGN GOITERS
ECTOPIC THYROID TISSUE
CT AND PREOPERATIVE PLANNING OF THYROID CARCINOMAS, LYMPHOMAS, AND METASTASIS
CT AND FOLLOW-UP OF THYROID CARCINOMAS
MAGNETIC RESONANCE IMAGING
BASIC PHYSICS PRINCIPLES (41)
NORMAL THYROID TISSUE
DIFFUSE THYROID DISEASE
THYROID INCIDENTALOMAS AND NODULE CHARACTERIZATION
PREOPERATIVE PLANNING OF THYROID CARCINOMAS: ASSESSING INVASION (48)
FOLLOW-UP OF THYROID CARCINOMAS
CONCLUSION
REFERENCES
Chapter 19: Thyroid radionuclide uptake and imaging studies
INTRODUCTION
RADIOPHARMACEUTICALS
MODALITIES
RADIOIODINE
UPTAKE STUDIES
PLANAR IMAGING: HYPERTHYROIDISM
PLANAR IMAGING: THYROID CANCER
TOMOGRAPHY
DOSIMETRY
FDG PET/CT IN THYROID CANCER
FDG PET/CT IN INCIDENTAL THYROID DISEASE
IMAGING OF MEDULLARY THYROID CANCER
CONCLUSIONS
REFERENCES
Chapter 20: Cytopathology of the thyroid gland
INTRODUCTION
SPECIMEN PREPARATIONS
THYROID FNA CLASSIFICATION
NONDIAGNOSTIC OR UNSATISFACTORY (CATEGORY I)
BENIGN (CATEGORY II)
ATYPIA OF UNDETERMINED SIGNIFICANCE/FOLLICULAR LESION OF UNDETERMINED SIGNIFICANCE (AUS/FLUS) (CATEGORY III)
FOLLICULAR OR ONCOCYTIC (HüRTHLE-CELL) NEOPLASM OR SUSPICIOUS FOR FOLLICULAR OR ONCOCYTIC (HüRTHLE-CELL) NEOPLASM (CATEGORY IV)
SUSPICIOUS FOR MALIGNANCY (CATEGORY V)
MALIGNANT (CATEGORY VI)
CORE NEEDLE BIOPSY
KEY CYTOMORPHOLOGIC FEATURES OF THYROID FINE-NEEDLE ASPIRATION DIAGNOSES
DIFFUSE TOXIC GOITER
CHRONIC LYMPHOCYTIC THYROIDITIS (11,15)
ATYPIA OF UNDETERMINED SIGNIFICANCE/FOLLICULAR LESION OF UNDETERMINED SIGNIFICANCE (AUS/FLUS)
SUSPICIOUS FOR FOLLICULAR NEOPLASM/FOLLICULAR NEOPLASM (INCLUDING TUMORS WITH ONCOCYTIC FEATURES)
MALIGNANT LESIONS
PAPILLARY THYROID CARCINOMA AND ITS VARIANTS
MEDULLARY THYROID CARCINOMA
POORLY DIFFERENTIATED CARCINOMA
ANAPLASTIC CARCINOMA
ROLE OF ANCILLARY STUDIES IN THE DIAGNOSIS OF THYROID TUMORS IN CYTOLOGIC SPECIMENS’ IMMUNOHISTOCHEMISTRY
REFERENCES
Chapter 21: Histopathology of the thyroid gland
NORMAL THYROID
PATHOLOGIC DIAGNOSIS OF THYROID LESIONS
DEVELOPMENTAL VARIATIONS
GOITER
GRAVES DISEASE/DIFFUSE TOXIC GOITER
DYSHORMONOGENETIC GOITER
IATROGENIC AND RELATED HYPERPLASIAS
AUTOIMMUNE THYROIDITIS
SILENT THYROIDITIS
SPECIFIC INFECTIOUS THYROIDITIS
GRANULOMATOUS THYROIDITIS
PALPATION THYROIDITIS
AMIODARONE INJURY WITH THYROTOXICOSIS
RIEDEL THYROIDITIS (AKA RIEDEL STRUMA)
COMBINED RIEDEL STRUMA AND FIBROSING HASHIMOTO THYROIDITIS
MISCELLANEOUS DISORDERS
RADIATION EFFECTS
AMYLOIDOSIS
BLACK THYROID
NEOPLASMS
BENIGN NEOPLASMS
ADENOMAS AND ADENOMATOUS NODULES
MALIGNANT NEOPLASMS
PAPILLARY CARCINOMA
FOLLICULAR CARCINOMA
HÜRTHLE-CELL NEOPLASM/ONCOCYTIC FOLLICULAR NEOPLASM
PATHOLOGIC DIAGNOSIS OF PAPILLARY AND FOLLICULAR CARCINOMA OF THYROID: CONTROVERSIES
CLEAR CELL TUMORS
HIGH-GRADE THYROID CARCINOMA
POORLY DIFFERENTIATED THYROID CARCINOMA
ANAPLASTIC CARCINOMA
SQUAMOUS CELL CARCINOMA, MUCOEPIDERMOID CARCINOMA, AND INTRATHYROIDAL THYMOMA-LIKE NEOPLASMS
MEDULLARY THYROID CARCINOMA
CALCITONIN NEGATIVE NEUROENDOCRINE CARCINOMA OF THYROID
LYMPHOMA
SARCOMA
CARCINOMA IN ECTOPIC THYROID TISSUE
METASTATIC NEOPLASMS
REFERENCES
Section III: Thyroid Diseases: Thyrotoxicosis
A. Causes of Thyrotoxicosis
Chapter 22: Pathogenesis of Graves disease
INTRODUCTION
AUTOIMMUNITY
DEFINITION OF AN AUTOANTIGEN
THE NATURE OF T CELLS
ANTIBODY AND T-CELL INTERACTIONS WITH ANTIGEN
SECOND SIGNALS
CRITERIA FOR AN AUTOIMMUNE DISEASE
RESTRICTION VERSUS POLYCLONALITY
THYROID IMMUNOLOGY
INTRATHYROIDAL B CELLS
AUTOANTIBODIES TO THE HUMAN TSHR
BIOACTIVITY OF TSHR ANTIBODIES
PREVALENCE OF TSHR ANTIBODIES IN GRAVES DISEASE
IMMUNOLOGIC CHARACTERISTICS OF TSHR ANTIBODIES
TSHR FUNCTION IN GRAVES DISEASE
LESSONS FROM MONOCLONAL TSHR ANTIBODIES WITH STIMULATING ACTIVITY
OTHER THYROID ANTIBODIES IN GRAVES DISEASE
THE INTRATHYROIDAL LYMPHOCYTIC INFILTRATE
FUNCTIONAL ANALYSIS OF INTRATHYROIDAL T CELLS
T-CELL SELECTION
APOPTOSIS IN GRAVES DISEASE
THE INTRATHYROIDAL T-CELL RECEPTOR V GENE REPERTOIRE
REGULATORY EFFECTS OF T CELLS IN AUTOIMMUNE THYROID DISEASE
THE Th17 CELLS
IMMUNE MECHANISMS IN THE PATHOGENESIS OF GRAVES DISEASE
FAILURE OF IMMUNE CELL DELETION AND/OR SUPPRESSION
SPECIFICITY CROSSOVER (MOLECULAR MIMICRY)
BYSTANDER EFFECTS
EPIGENETIC CHANGES
THYROID CELL EXPRESSION OF HLA MOLECULES
ANIMAL MODELS OF GRAVES DISEASE
KNOWN RISK FACTORS FOR PRECIPITATING GRAVES DISEASE (TABLE 22-5)
SUSCEPTIBILITY GENES
INFECTION
THYROID AUTOANTIBODIES
THYROID TISSUE DAMAGE
STRESS
SEX STEROIDS
THE X CHROMOSOME
THE POSTPARTUM PERIOD
MATERNAL MICROCHIMERISM
IODINE
IRRADIATION
OVERVIEW OF THE ETIOLOGY OF GRAVES DISEASE
REFERENCES
Chapter 23: Thyrotropin-induced thyrotoxicosis
INTRODUCTION
EPIDEMIOLOGY
PATHOLOGIC AND PATHOGENIC ASPECTS
SIGNS AND SYMPTOMS
LABORATORY AND BIOCHEMICAL FEATURES
SERUM THYROTROPIN AND THYROID HORMONE LEVELS
PITUITARY GLYCOPROTEIN HORMONE α-SUBUNIT
PARAMETERS OF PERIPHERAL THYROID HORMONE ACTION
DIAGNOSTIC TESTING
IMAGING STUDIES AND LOCALIZATION
DIFFERENTIAL DIAGNOSIS
TREATMENT AND OUTCOME
CRITERIA OF CURE AND FOLLOW-UP
REFERENCES
Chapter 24: Toxic adenoma and toxic multinodular goiter
EPIDEMIOLOGY
CLINICAL ASPECTS OF THYROID AUTONOMY
DIAGNOSIS OF THYROID AUTONOMY
NATURAL HISTORY
MORPHOLOGY
ETIOLOGY
LESSONS FROM EPIDEMIOLOGIC STUDIES
FROM HYPERPLASTIC GROWTH TO NODULAR TRANSFORMATION
TRANSFORMATION TO HOT THYROID NODULES
TREATMENT OF AUTONOMOUS THYROID NODULES (SEE CHAPTER 32)
SURGERY
RADIOIODINE THERAPY
COST-EFFECTIVE MANAGEMENT OF THYROID AUTONOMY
FOLLOW-UP
ACKNOWLEDGMENT
REFERENCES
Chapter 25: Trophoblastic tumors
INTRODUCTION
HUMAN CHORIONIC GONADOTROPIN
GRADATIONS OF SEVERITY
CLINICAL FEATURES
DIAGNOSIS
HYPEREMESIS GRAVIDARUM
MUTANT THYROID-STIMULATING HORMONE RECEPTOR
THERAPY
REFERENCES
Chapter 26: Sporadic painless, painful subacute and acute infectious thyroiditis
INTRODUCTION
DESTRUCTION-INDUCED THYROIDITIS
PAINFUL THYROID
SPORADIC PAINLESS THYROIDITIS
ETIOLOGY
CLINICAL MANIFESTATIONS
LABORATORY FINDINGS
CYTOLOGY
IMAGING
PATHOLOGY
DIFFERENTIAL DIAGNOSIS
CLINICAL MANAGEMENT
SUBACUTE THYROIDITIS
ETIOLOGY
INFECTIOUS ASSOCIATION
AUTOIMMUNE ASSOCIATION
GENETIC ASSOCIATION
CLINICAL MANIFESTATIONS
LABORATORY FINDINGS
CYTOLOGY
IMAGING
PATHOLOGY
DIFFERENTIAL DIAGNOSIS
CLINICAL MANAGEMENT
ACUTE INFECTIOUS THYROIDITIS
ETIOLOGY
BACTERIAL INFECTIONS
FUNGAL INFECTIONS
MYCOBACTERIAL INFECTIONS
PARASITIC INFECTIONS
SYPHILITIC INFECTIONS
THYROIDAL INFECTIONS IN IMMUNOCOMPROMISED PATIENTS
CLINICAL MANIFESTATIONS
LABORATORY FINDINGS
CYTOLOGY
IMAGING STUDIES
CLINICAL MANAGEMENT
REFERENCES
Chapter 27: Thyrotoxicosis of extrathyroidal origin
INTRODUCTION
EXOGENOUS THYROID HORMONE
CAUSES
CLINICAL PRESENTATION AND DIAGNOSIS
TREATMENT
THYROTOXICOSIS DUE TO METASTATIC THYROID CARCINOMA
DEFINITION AND EPIDEMIOLOGY
CLINICAL PRESENTATION AND DIAGNOSIS
TREATMENT
STRUMA OVARII
DEFINITION AND EPIDEMIOLOGY
CLINICAL PRESENTATION AND DIAGNOSIS
TREATMENT
ACKNOWLEDGMENT
REFERENCES
B. Organ System Manifestations
Chapter 28: Overview of the clinical manifestations of thyrotoxicosis
INTRODUCTION
PREVALENCE OF CLINICAL FINDINGS
ORGAN SYSTEM–SPECIFIC MANIFESTATIONS
CENTRAL NERVOUS SYSTEM
BEHAVIORAL HEALTH MANIFESTATIONS
CARDIOVASCULAR MANIFESTATIONS
PULMONARY MANIFESTATIONS
GASTROINTESTINAL MANIFESTATIONS
RENAL MANIFESTATIONS
INTEGUMENTARY FINDINGS
MUSCULOSKELETAL MANIFESTATIONS
REPRODUCTIVE CHANGES
HEMATOLOGIC MANIFESTATIONS
MODULATING FACTORS
AGE
PREGNANCY
COMORBIDITY
ETIOLOGY OF THYROTOXICOSIS
CLINICAL ASSESSMENT
REFERENCES
Chapter 29: Ophthalmopathy
INTRODUCTION
EPIDEMIOLOGY AND NATURAL HISTORY
PATHOGENESIS
RISK FACTORS AND PREVENTION
CLINICAL PRESENTATION
DIAGNOSIS
TREATMENT OF HYPERTHYROIDISM IN PATIENTS WITH GO
MANAGEMENT OF GO
CONCLUSIONS
REFERENCES
Chapter 30: The cardiovascular system in thyrotoxicosis
THYROID HORMONE ACTION ON THE HEART AND VASCULAR SYSTEM
CLINICAL CONSEQUENCES OF THYROTOXICOSIS
CARDIOVASCULAR SYMPTOMS AND SIGNS IN THYROTOXICOSIS
ATRIAL FIBRILLATION
ELECTROCARDIOGRAPHIC CHANGES
HEART FAILURE
HYPERTENSION AND VASCULAR DYSFUNCTION
MAJOR ADVERSE CARDIOVASCULAR EVENTS
ROLE OF OTHER HORMONES IN THYROTOXICOSIS
SUBCLINICAL THYROTOXICOSIS
AMIODARONE AND IODINE CONTAINING CONTRAST AGENTS
REFERENCES
Chapter 31: Thyroid hormones in intermediary metabolism, thermogenesis, and obesity
THYROID HORMONE SIGNALING, TISSUE- AND TARGET GENE–SPECIFICITY IN RELATION TO INTERMEDIARY AND ENERGY METABOLISM
THYROID HORMONE ACTION ON INTERMEDIARY METABOLISM
CARBOHYDRATE METABOLISM
CLINICAL CORRELATES
PROTEIN METABOLISM
CLINICAL CORRELATES
LIPID METABOLISM
CLINICAL CORRELATES
THYROID HORMONE ACTION ON ENERGY METABOLISM
THYROID HORMONE ACTION ON RESTING ENERGY EXPENDITURE
THYROID HORMONE ACTION ON ADAPTIVE THERMOGENESIS
THYROID HORMONE ACTION ON ACTIVITY-RELATED ENERGY EXPENDITURE
THYROID HORMONE ACTION ON THERMIC EFFECT OF FOOD
ENERGY STATUS AND THYROID HORMONE HOMEOSTASIS
CLINICAL CORRELATES
POTENTIAL USE OF THYROID HORMONE AS TREATMENT FOR WEIGHT LOSS AND DYSLIPIDEMIA
CONCLUSIONS
ACKNOWLEDGMENTS
REFERENCES
Chapter 32: The skeletal system in thyrotoxicosis
REGULATION OF THYROID STATUS
CONTROL OF INTRACELLULAR T3 AVAILABILITY
MECHANISM OF THYROID HORMONE ACTION
ROLE OF TSH IN BONE
BONE REMODELING CYCLE
SKELETAL CONSEQUENCES OF CHILDHOOD THYROTOXICOSIS
SKELETAL EFFECTS OF THYROID HORMONES IN ADULTS
POPULATION STUDIES IN NORMAL EUTHYROID INDIVIDUALS
STUDIES OF ADULT THYROTOXICOSIS
EFFECTS OF TREATMENT FOR THYROTOXICOSIS
SUBCLINICAL HYPERTHYROIDISM
PATIENTS TREATED WITH SUPPRESSIVE DOSES OF THYROXINE
REFERENCES
Chapter 33: Thyroid dermopathy and thyroid acropachy
THYROID DERMOPATHY
HISTOLOGIC FINDINGS IN THYROID DERMOPATHY
CLINICAL MANIFESTATIONS
PATHOGENESIS
DIFFERENTIAL DIAGNOSIS
TREATMENT
OUTCOMES OF THERAPY OF THYROID DERMOPATHY
FUTURE DIRECTIONS FOR THERAPY
THYROID ACROPACHY
REFERENCES
Chapter 34: Psychiatric and cognitive effects of thyrotoxicosis
INTRODUCTION
NEUROPSYCHIATRIC MANIFESTATIONS OF OVERT THYROTOXICOSIS
COGNITIVE MANIFESTATIONS OF OVERT THYROTOXICOSIS
SUBCLINICAL THYROTOXICOSIS: NEUROPSYCHIATRIC AND COGNITIVE ASPECTS
DIFFERENTIAL DIAGNOSIS: BEHAVIORAL SYNDROMES THAT MAY MIMIC THYROTOXICOSIS
PSYCHOLOGICAL FACTORS IN THE PATHOPHYSIOLOGY OF THYROTOXICOSIS
TREATMENT OF THYROTOXICOSIS: NEUROPSYCHIATRIC ASPECTS
POSSIBLE LINK BETWEEN THYROID HORMONE AND ATTENTION DEFICIT/HYPERACTIVITY DISORDER
USE OF THYROID HORMONE IN AFFECTIVE DISORDERS
LITHIUM AND THYROID FUNCTION
REFERENCES
Chapter 35: Thyrotoxic storm
CLINICAL FEATURES
LABORATORY FINDINGS
PATHOGENESIS
TREATMENT
THERAPY TO REDUCE THYROID HORMONE SYNTHESIS AND SECRETION
THERAPY DIRECTED AGAINST SYSTEMIC DISTURBANCES
THERAPY DIRECTED AGAINST THE PERIPHERAL ACTIONS OF THYROID HORMONE
THERAPY DIRECTED AGAINST PRECIPITATING ILLNESS
REFERENCES
C. Diagnosis and Management of Thyrotoxicosis
Chapter 36: Diagnosis of thyrotoxicosis
INTRODUCTION
CLINICAL DIAGNOSIS
CLUES FROM ROUTINE LABORATORY TESTS
LABORATORY TESTING FOR THYROTOXICOSIS
SERUM THYROXINE DETERMINATIONS
SERUM TRIIODOTHYRONINE DETERMINATIONS
SERUM THYROTROPIN DETERMINATIONS
SCREENING, CASE FINDING, AND DIAGNOSIS
DIAGNOSING THE CAUSE OF THYROTOXICOSIS
REFERENCES
Chapter 37: Treatment of thyrotoxicosis
INTRODUCTION
THYROTOXICOSIS CAUSED BY GRAVES DISEASE
DRUG THERAPY OF THYROTOXICOSIS CAUSED BY GRAVES DISEASE
ANTITHYROID DRUGS (Fig. 37-1)
MECHANISMS OF ACTION
INTRATHYROIDAL ACTIONS
EXTRATHYROIDAL ACTIONS
EFFECTS ON THE IMMUNE SYSTEM
CLINICAL PHARMACOLOGY OF THE ANTITHYROID DRUGS
METHIMAZOLE
PROPYLTHIOURACIL
CLINICAL CONSIDERATIONS IN THE USE OF ANTITHYROID DRUGS
SIDE EFFECTS OF ANTITHYROID DRUGS
FOLLOW-UP OF PATIENTS TAKING AN ANTITHYROID DRUG FOR GRAVES DISEASE
REMISSIONS AND ANTITHYROID DRUG THERAPY
THERAPY FACTORS RELATING TO REMISSION OF GRAVES DISEASE
DISCONTINUATION OF ANTITHYROID DRUG THERAPY
OTHER DRUGS USED IN THE TREATMENT OF THYROTOXICOSIS CAUSED BY GRAVES DISEASE
INORGANIC IODIDE
ORAL CHOLECYSTOGRAPHIC AGENTS
β-ADRENERGIC ANTAGONIST DRUGS
RADIOACTIVE IODINE THERAPY FOR THYROTOXICOSIS (Fig. 37-1)
PRACTICAL THERAPEUTIC CONSIDERATIONS
COMPLICATIONS AND POTENTIAL RISKS OF RADIOIODINE THERAPY
POSTRADIOIODINE WORSENING OF THYROID FUNCTION
RADIOIODINE THERAPY AND GRAVES OPHTHALMOPATHY
INDICATIONS FOR RADIOIODINE THERAPY
SURGICAL THERAPY FOR THYROTOXICOSIS (Fig. 37-1)
SPECIAL CONSIDERATIONS IN THE TREATMENT OF THYROTOXICOSIS
TREATMENT OF CHILDREN AND ADOLESCENTS
TREATMENT OF ELDERLY PATIENTS
THYROTOXICOSIS IN PREGNANT WOMEN AND DURING LACTATION
THYROTOXIC STORM
THYROTOXICOSIS DUE TO TOXIC ADENOMA AND MULTINODULAR GOITER
TOXIC ADENOMA
TOXIC MULTINODULAR GOITER
REFERENCES
Chapter 38: Subclinical thyrotoxicosis
ETIOLOGY
ENDOGENOUS SUBCLINICAL THYROTOXICOSIS
EXOGENOUS SUBCLINICAL THYROTOXICOSIS
EVALUATION
DIFFERENTIAL DIAGNOSIS
EPIDEMIOLOGY AND NATURAL HISTORY
CLINICAL AND BIOLOGIC IMPORTANCE
PHYSIOLOGY OF SUPPRESSION OF TSH SECRETION
CARDIOVASCULAR CONSEQUENCES
BONE AND MINERAL METABOLISM
COGNITIVE DYSFUNCTION AND DEMENTIA
TREATMENT
CHOICE OF TREATMENT MODALITY
SIDE EFFECTS OF TREATMENT FOR SUBCLINICAL THYROTOXICOSIS
FUTURE DIRECTIONS
REFERENCES
Section IV: Thyroid Diseases: Hypothyroidism
A. Causes of Hypothyroidism
Chapter 39: Chronic autoimmune thyroiditis
INTRODUCTION
PREDISPOSITION TO CHRONIC AUTOIMMUNE THYROIDITIS
PATHOGENESIS OF CHRONIC AUTOIMMUNE THYROIDITIS
ANTIGEN PRESENTATION
T-CELL RESPONSES
B-CELL RESPONSES
EFFECTOR MECHANISMS
EXPERIMENTAL AUTOIMMUNE THYROIDITIS
CLINICAL ASPECTS
ASSOCIATED DISORDERS
REFERENCES
Chapter 40: Genetic defects causing hypothyroidism
MONOGENIC CAUSES OF THYROID DYSGENESIS
KEY TRANSCRIPTION FACTOR MUTATIONS IN TD
NKX2-1
PAX8
FOXE1
GLIS3
TSHR
ADDITIONAL GENES ASSOCIATED WITH TD
NKX2-5
JAG1
CDCA8 (BOREALIN)
TUBB1
NETRIN 1 (NTN1)
SYNDROMES WHICH MAY BE ASSOCIATED WITH CH
GENETIC CAUSES OF DYSHORMONOGENESIS
THYROGLOBULIN
TPO
DUOX2 AND DUOXA2
IYD (PREVIOUSLY KNOWN AS DEHAL1)
SLC5A5 (NIS)
SLC26A4 (PENDRIN)
SLC26A7
EVIDENCE FOR AN UNDIAGNOSED GENETIC COMPONENT IN TD
REFERENCES
Chapter 41: Primary hypothyroidism due to other causes
INTRODUCTION
RADIOACTIVE IODINE (131I THERAPY)
THYROIDECTOMY
TREATMENT OF TOXIC NODULAR GOITER
TREATMENT OF NONTOXIC NODULAR GOITER
EXTERNAL RADIATION
HYPOTHYROIDISM DUE TO THERAPEUTIC PHARMACOLOGIC AGENTS
LITHIUM CARBONATE
CYTOKINES
AMIODARONE
TYROSINE KINASE INHIBITORS
IMMUNE CHECKPOINT INHIBITORS
OTHER DRUGS
HYPOTHYROIDISM DUE TO INFILTRATIVE DISORDERS
RIEDEL THYROIDITIS (INVASIVE FIBROUS THYROIDITIS)
AMYLOIDOSIS
SARCOIDOSIS
SCLERODERMA
HEMOCHROMATOSIS
CYSTINOSIS
OTHER INFILTRATIVE OR INFECTIOUS DISORDERS (SEE CHAPTER 22)
PRIMARY THYROID LYMPHOMA
CONSUMPTIVE HYPOTHYROIDISM
INDUSTRIAL AND ENVIRONMENTAL AGENTS (SEE CHAPTER 12)
EMBRYOLOGIC VARIANTS
LINGUAL THYROID (SEE CHAPTER 63)
REFERENCES
Chapter 42: Central hypothyroidism
INTRODUCTION
EPIDEMIOLOGY
PATHOGENESIS
CLINICAL FEATURES AND DIAGNOSIS
TREATMENT OF CeH
REFERENCES
B. Organ System Manifestations of Hypothyroidism
Chapter 43: Overview of the clinical manifestations of hypothyroidism
INTRODUCTION
CLINICAL MANIFESTATIONS
OVERT HYPOTHYROIDISM
SUBCLINICAL HYPOTHYROIDISM
CARDIOVASCULAR DISEASE AND MORTALITY
PULMONARY SYSTEM
NEUROPSYCHIATRIC FEATURES
MUSCULOSKELETAL SYSTEM
INFECTIOUS COMPLICATIONS
SKIN AND CONNECTIVE TISSUE
KIDNEYS AND ELECTROLYTE METABOLISM
GASTROINTESTINAL TRACT AND LIVER
HEMATOLOGY AND HEMOSTASIS
PITUITARY DISORDERS IN HYPOTHYROIDISM
ADRENAL DISORDERS IN HYPOTHYROIDISM
SUMMARY
REFERENCES
Chapter 44: Hypothyroidism and the heart
CLINICAL CONSEQUENCES OF HYPOTHYROIDISM
CV SYMPTOMS AND SIGNS
ELECTROCARDIOGRAPHIC CHANGES IN HYPOTHYROIDISM
CORONARY ARTERY DISEASE IN HYPOTHYROIDISM
CV RISK FACTORS IN HYPOTHYROIDISM
LIPIDS
BLOOD PRESSURE AND VASCULAR DYSFUNCTION
THROMBOGENESIS
SUBCLINICAL HYPOTHYROIDISM
SPECIAL SITUATIONS IN HYPOTHYROIDISM RELATED TO THE HEART
POSTACUTE MYOCARDIAL INFARCTION
HEART FAILURE
TREATMENT OF HYPOTHYROIDISM IN PATIENTS WITH CORONARY ARTERY DISEASE
CARDIAC SURGERY AND CARDIAC TRANSPLANTATION PROCEDURES
REFERENCES
Chapter 45: The skeletal system in hypothyroidism
PHYSIOLOGIC CONTROL OF THYROID HORMONE ACTION
THYROID HORMONE TRANSPORT AND METABOLISM IN BONE
THYROID HORMONE RECEPTOR FUNCTION IN BONE
ROLE OF TSH ON SKELETAL GROWTH AND MATURATION
SKELETAL DEVELOPMENT
SKELETAL CONSEQUENCES OF CHILDHOOD HYPOTHYROIDISM
SKELETAL CONSEQUENCES OF IMPAIRED SENSITIVITY TO THYROID HORMONE
SKELETAL CONSEQUENCES OF ADULT HYPOTHYROIDISM
- Includes thorough updates and new content throughout the text, especially on thyroid cytopathology, thyroid imaging, and targeted therapy of thyroid cancer as well as a new full-color format.