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  • 495.00 lei

     Editia a opta Manualului AJCC de Stadializare a Cancerului reprezinta un compendiu al tuturor informatiilor disponibile referitoare la stadializarea tumorilor maligne ale adultului pentru toate localizarile anatomice vizate. Acest volum constituie rezultatul cooperarii dintre Comitetul Unit American pentru Cancer (AJCC) si Comitetul TNM al Uniunii pentru Controlul International al Cancerului (UICC), fiind un material esential utilizat de medici, pentru a facilita descrierea si raportarea uniforma a bolilor neoplazice. Sunt cuprinse 12 sisteme de stadializare complet noi, o gama largă de definitii modificate, iar accentul se muta asupra abordarii personalizate a cancerului. Cea de‑a opta editie a Manualului AJCC, tradusa excelent in limba romana, ramane resursa indispensabila pentru oncologi, hematologi, radioterapeuti, chirurgi, patologi, radiologi, pentru toti profesionistii implicati activ in lupta contra cancerului.

     

    De ce un manual de stadializare a cancerului?

    Stadializarea tumorilor maligne joaca un rol esential in lupta contra cancerului. Manualul AJCC de Stadializare a Cancerului este utilizat de medici si profesionisti din domeniul sanatatii din intreaga lume, pentru a facilita descrierea si raportarea uniforma a bolilor neoplazice. Clasificarea corecta si stadializarea afectiunilor oncologice sunt esențiale pentru un management terapeutic adecvat, pentru evaluarea rezultatelor din cadrul studiilor clinice si reprezinta totodata modelul standard pentru raportarea locala, regionala si internationala privind incidenta si evolutia cancerului.

     

    Cea de‑a opta Editie a Manualului AJCC de Stadializare a Cancerului ramane standardul indispensabil pentru oncologi, chirurgi, anatomopatologi, radiologi, registratori de cancer si pentru toțt profesionistii din domeniul medical din intreaga lume, fiind asigurat astfel faptul că toti specialistii care se ocupă de bolnavii de cancer sunt pe deplin pregatiti cu privire la termenii de stadializare a maladiilor oncologice.

     


  • 150.00 lei

     Editia a opta a manualului Clasificarea TNM a Tumorilor Maligne pune la dispozitie ultimele consensuri si standarde internationale utilizate pentru a descrie si a caracteriza corespunzator stadiile maladiilor oncologice. Editat in afiliere cu Uniunea pentru Controlul International al Cancerului (UICC), acest „ghid de buzunar”, autorizat si unanim recunoscut, contine importante clasificari reactualizate pentru localizari tumorale specifice, de catre medicii oncologi si profesionistii din domeniul sanatatii, implicati in managementul terapeutic al pacientilor afectati de aceste boli, trebuie sa țina cont pentru stadializarea, clasificarea, prognosticul si atitudinea terapeutica optima privind aceste maladii.

    •       In acest „ghid de buzunar” omologat international, se gasesc ultimele noutati privind atat stadializarea carcinoamelor de cap si gat, a carcinoamelor tiroidiene, esofagiene, gastrice, colorectale, pulmonare, pleurale, a tumorilor cutanate, ovariene, de prostata, ale glandului si ale cortexului suprarenal, cat si stadializarea tumorilor neuroendocrine, a sarcoamelor osoase si de tesuturi moi, dispuse intr‑o maniera simpla si precisa, pe regiuni anatomice.

    •       In această editie, sunt introduse noi clasificari pentru carcinoamele orofaringiene p16‑pozitive, tumorile timice, tumorile neuroendocrine cu origine pancreatica, pentru sarcoame ale coloanei vertebrale si ale pelvisului, sarcoame de tesuturi moi ale capului si ale gatului, toracice, tumori cu originea in viscerele abdominale si in spatiul retroperitoneal.

    •        Pentru a inlesni colectarea datelor necesare clasificarii si monitorizarii maladiilor oncologice in țarile cu venituri mici si mijlocii, au fost adaugate noi sectiuni in capitolul Schema Esentială TNM in ceea ce priveste tumorile de colon, rect, cele ale glandei mamare si ale colului uterin si carcinoamele prostatei, dar si stadializari simplificate pentru tumorile pediatrice.

    •       Structura limpede si prelucrata pe baza unor tipare usor de utilizat a capitolelor care cuprind subdiviziuni anatomice, retele de drenaj ganglionar, clasificarea clinică si patologică TNM, gradul histopatologic, gruparea pe stadii si, mai nou, gruparea in functie de prognostic (acolo unde este relevant) permite accesul fara intarziere la informatii‑cheie.

    Un format reactualizat si cromatica folosita rafineaza si sporeste gradul de întrebuintare a acestei resurse indispensabile pentru toți specialistii din medicina, oncologi, radioterapeuti, chirurgi, patologi, asistenti medicali, persoane abilitate sa ofere îngrijiri paliative, pentru centre internaționale dedicate terapiilor cu viza oncologica, organizații guvernamentale si non‑guvernamentale implicate activ in lupta contra cancerului.

    DESPRE UICC

    „Unim comunitatea afectata de maladiile oncologice pentru a reduce problema globala pe care acestea o reprezinta, promovam echitatea si integram controlul neoplaziilor in agenda universala pentru sanatate si dezvoltare”.

     

  • 21000lei 185.00 lei

    In curand si in limba romana!

    TNM Classification of Malignant Tumours eighth edition provides the latest, internationally agreed-upon standards to describe and categorize cancer stage. 
    • Published in affiliation with the Union for International Cancer Control (UICC)
    • Arranged by anatomical region, this authoritative pocket sized guide contains many important updated organ-specific classifications 
    • There are new classifications for p16 positive oropharyngeal carcinomas, carcinomas of the thymus, neuroendocrine tumours of the pancreas, and sarcomas 
    • To facilitate the collection of stage data for cancer surveillance in low and middle income countries there are new sections on Essential TNM and Paediatric Cancer Stage
    • New colour presentation

  • Pocket Radiation Oncology (Pocket Notebook)
    by Tang
    La comanda in aproximativ 4 saptamani
    20800lei 185.00 lei

     


    Pocket Radiation Oncology is a practical, high-yield reference offering current, evidence-based practices and expert guidance from physicians at the world-renowned MD Anderson Cancer Center. Featuring an easy-to-use, loose-leaf format, it serves as a concise clinical companion and board study guide for medical students, residents, and attending physicians in radiation oncology. Follows the popular Pocket Notebook format, featuring bulleted lists, tables, diagrams, and algorithms that make essential facts easy to find and retain. Emphasizes key literature and clinical trials in every section. Provides solutions to day-to-day management decisions in radiation oncology, including management of radiation induced symptoms, radiation physics, radiation biology, pediatrics, and radiation emergencies.

    ·  Contents

    ·  RADIATION ONCOLOGY PRINCIPLES

    ·  Radiation Biology

    ·  Radiation Physics

    ·  Imaging and Radiology

    ·  Chemotherapy and Immunotherapy

    ·  Clinical Statistics

    ·  SPECIAL RADIATION TECHNIQUES

    ·  Brachytherapy

    ·  Proton Therapy

    ·  Oligometastatic Disease

    ·  Stereotactic Body Radiation Therapy

    ·  Stereotactic CNS Radiosurgery

    ·  CENTRAL NERVOUS SYSTEM

    ·  Low-Grade Gliomas

    ·  High-Grade Gliomas

    ·  Meningioma

    ·  Benign CNS

    ·  Pituitary Adenoma and Craniopharyngioma

    ·  PEDIATRICS

    ·  Medulloblastoma

    ·  Ependymoma

    ·  Intracranial Germ Cell Tumor

    ·  Wilms Tumor

    ·  Neuroblastoma

    ·  Ewing Sarcoma

    ·  Rhabdomyosarcoma

    ·  Osteosarcoma/Retinoblastoma/Brainstem Glioma

    ·  Late Effects

    ·  HEAD & NECK

    ·  Oral Cavity

    ·  Oropharynx

    ·  Sinonasal and Nasopharynx

    ·  Larynx and Hypopharynx

    ·  Salivary Gland Neoplasms

    ·  Thyroid Cancer

    ·  Unknown Head and Neck Primary

    ·  THORACIC

    ·  Early-Stage NSCLC

    ·  Stage III NSCLC

    ·  Small Cell Lung Cancer

    ·  Thymoma and Thymic Carcinoma

    ·  Mesothelioma

    ·  Esophageal Cancer

    ·  GASTROINTESTINAL

    ·  Colorectal Cancer

    ·  Anal Cancer

    ·  Pancreatic Cancer

    ·  Gastric Cancer

    ·  Hepatobiliary Cancer

    ·  BREAST

    ·  General Breast Cancer

    ·  Ductal Carcinoma In Situ (DCIS)

    ·  Early-Stage Breast Cancer (ESBC)

    ·  Locally Advanced Breast Cancer (LABC)

    ·  Inflammatory/Recurrent Breast Cancer

    ·  GENITOURINARY

    ·  Prostate Cancer (Definitive)

    ·  Prostate Cancer (Adjuvant/Salvage)

    ·  Bladder Cancer

    ·  Testicular Cancer

    ·  Penile Cancer

    ·  GYNECOLOGIC

    ·  Cervical Cancer

    ·  Endometrial Cancer

    ·  Vaginal Cancer

    ·  Vulvar Cancer

    ·  Ovarian Cancer

    ·  SKIN/SARCOMA

    ·  Soft Tissue Sarcoma

    ·  Melanoma

    ·  Non-melanoma Skin Cancer

    ·  Merkel Cell Carcinoma

    ·  LYMPHOMA

    ·  Hodgkin Lymphoma

    ·  Diffuse Large B-Cell Lymphoma

    ·  Miscellaneous Hematologic Malignancies

    ·  RADIATION EMERGENCIES, BENIGN DISEASE, AND PALLIATION

    ·  Brain Metastases

    ·  Spine Metastases

    ·  Non-spine Bone Metastases

    ·  Radiation Emergencies

    ·  Benign Disease: Non-neural

    ·  Clinical Setup


  • A Beginner's Guide to Targeted Cancer Treatments
    La comanda in aproximativ 4 saptamani
    24400lei 200.00 lei

     

    The accessible guide to the principles behind new, more targeted drug treatments for cancer

    Written for anyone who encounters cancer patients, cancer data or cancer terminology, but have no more than a passing knowledge of cell biology. A Beginner's Guide to Targeted Cancer Treatments provides an understanding of how cancer works and the many new treatments available.

    Using over 100 original illustrations, this accessible handbook covers the biology and mechanisms behind a huge range of targeted drug treatments, including many new immunotherapies. Dr Vickers translates a complex and often overwhelming topic into something digestible and easily understood. She also explains what cancer is, how it behaves and how our understanding of cancer has changed in recent years.

    Each chapter takes the reader through how new cancer drugs work and their benefits and limitations. With the help of this book, readers will be able to better understand more complex, in-depth articles in journals and books and develop their knowledge. This vital resource:

    ·         Offers the latest insights into cancer biology

    ·         Provides a broad understanding of how targeted cancer treatments work

    ·         Describes many of the new immunotherapy approaches to cancer treatment, such as checkpoint inhibitors and CAR-modified T cells

    ·         Helps readers feel confident discussing treatment options with colleagues and patients

    ·         Provides an overview of which treatments are relevant to each of the most common solid tumours and haematological cancers, and the rationale behind them

    ·         Demystifies the jargon – terms such as the EMT, cancer stem cells, monoclonal antibodies, kinase inhibitors, angiogenesis inhibitors etc.

    ·         Explains the resistance mechanisms to many new treatments, including issues such as the way cancer cells diversify and evolve and the complex environment in which they live

     

  • Clinical Oncology: Basic Principles and Practice
    La comanda in aproximativ 4 saptamani
    220.00 lei

     

    Book Description:

     

    This popular textbook provides a clear and comprehensive introduction to the principles and practice of clinical oncology. Ideal for medical undergraduates, clinicians and other health professionals who want to increase their understanding of the challenges of managing patients with cancer, the book enables readers to learn and then test themselves on all aspects of cancer medicine, from epidemiology, aetiology, pathogenesis and presentation, through to diagnosis, staging, management and prognosis.

     

    Table of Contents:

     

    List of abbreviations

    Preface

    Acknowledgement

    1. Pathogenesis of cancer

    2. Principles of cancer diagnosis and staging

    3. Decision-making and communication

    4. Principles of surgical oncology

    5. Principles of radiotherapy

    6. Principles of systemic treatment

    7. Lung cancer and mesothelioma

    8. Breast cancer

    9. Gastrointestinal cancer

    10. Urological cancer

    11. Gynaecological cancer

    12. CNS tumours

    13. Head and neck cancer

    14. Endocrine tumours

    15. Sarcomas

    16. Lymphoma

    17. Haematological malignancy

    18. Paediatric cancer

    19. Skin cancer

    20. Carcinoma of unknown primary

    21. Oncological emergencies

    22. Palliative care

    Appendix 1: Worldwide cancer burden – males and females

    Appendix 2: Worldwide cancer burden – males

    Appendix 3: Worldwide cancer burden – females

    Appendix 4: Answers to self-assessment questions

    Index

     

  • 27300lei 220.00 lei

     

    Description:

    Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. A must-have resource for oncologists, researchers, and other cancer care professionals!

     

    Table of Contents:

     

    Section 1 Targets by Organ Site

    Abbreviations

    Adrenocortical Carcinoma (ACC)—Mouhammed A. Habra, Aung Naing

    Biliary Tract Adenocarcinoma (Gallbladder, Bile Duct)—Milind Javle, Ahmed O. Kaseb, Goldy C. George, Kathrina Marcelo-Lewis, David S. Hong

    Bladder Carcinoma (Urothelial Cancer)—Arlene O. Siefker-Radtke

    Brain Tumors—Vivek Subbiah, Michael Pearlman

    Glioblastoma/Malignant Gliomas

    Other NF-Related Tumors

    Medulloblastoma

    Meningiomas

    Breast Cancer—Senthil Damodaran, Debu Tripathy

    ER/PR+

    HER2+

    Triple-Negative/Basal

    Cervical Cancer—Laura L. Holman, Siqing Fu, Shannon N. Westin

    Colorectal Cancer—Allan A. L. Pereira, David S. Hong, Goldy C. George, E. Scott Kopetz

    Esophageal Cancer (Squamous Cell)—Mustafa Bozkurt, David S. Hong, Goldy C. George, Mariela B. Murphy

    Gastric/Gastroesophageal Junction (Adenocarcinoma)—Mustafa Bozkurt, David S. Hong, Goldy C. George, Mariela Blum Murphy

    Head and Neck Cancer—Renata Ferrarotto, Kathrina Marcelo-Lewis, Sarina A. Piha-Paul, Sangeeta Goswami, Erminia Massarelli

    Salivary Gland

    Squamous Cell

    Nasopharynx

    Kidney (Renal Cell) Cancer—Vivek Subbiah, Nizar M. Tannir

    Leukemia—Prajwal C. Boddu, Radhika Kainthla, Tapan M. Kadia, Naveen Pemmaraju

    Acute Myeloid Leukemia (AML)

    Acute Lymphoblastic Leukemia (ALL)

    Chronic Myeloid Leukemia (CML)

    Chronic Lymphocytic Leukemia (CLL)

    Myeloproliferative Neoplasm (MPN)

    Liver Cancer (Hepatocellular)—Shiraj Sen, Xiaochun Liu, Ahmed O. Kaseb

    Lung Cancer—Daniel D. Karp, Kathrina Marcelo-Lewis, Ralph G. Zinner, Lauren Byers

    NSCLC

    SCLC

    Lymphoma— Raphael Steiner, Xiaochun Liu, Jason R. Westin

    Multiple Myeloma—Hans C. Lee, Manojkumar Bupathi, Jatin J. Shah, Robert Orlowski

    Ovarian Cancer—Laura L. Holman, Siqing Fu, Shannon N. Westin

    Pancreatic Cancer (Ductal Carcinoma)—Milind Javle, Kathrina Marcelo-Lewis, Goldy C. George, David S. Hong

    Prostate Cancer (Adenocarcinoma)—Paul G. Corn, Kathrina Marcelo-Lewis

    Sarcoma (Gastrointestinal Stromal Tumors, GIST)—Jason Roszik, Vivek Subbiah, Anthony Conley

    Sarcoma

    Skin Cancer—Gerald S. Falchook, Scott. Woodman, Michael K. K. Wong

    Melanoma—Meredith A. McKean, Gerald S. Falchook, Hussein Tawbi, Scott E. Woodman

    Basal Cell—Gerald S. Falchook, Scott E. Woodman, Michael K. K. Wong

    Squamous Cell—Gerald S. Falchook, Scott E. Woodman, Michael K. K. Wong

    Merkel Cell—Gerald S. Falchook, Scott E. Woodman, Michael K. K. Wong

    Testicular Cancer (Germ Cell Carcinoma)—Vivek Subbiah, Lance C. Pagliaro

    Thymus Carcinoma (Thymic and Thymoma)—Gerald S. Falchook, Ralph G. Zinner

    Thyroid Cancer—Maria E. Cabanillas, Manojkumar Bupathi

    Papillary and Follicular Carcinoma

    Papillary, Follicular, and Hurthle Cell Carcinoma

    Medullary Carcinoma

    Anaplastic Carcinoma

    Uterine (Endometrial) Cancer—Laura L. Holman, Siqing Fu, Shannon N. Westin

    Section 2 Carcinogenesis from the Perspective of Targeted Therapy and Immunotherapy

    Section 3 Molecular Targets and Pathways

    Signal Transduction–The Big Picture—Daniel D. Karp

    Color Key

    Angiogenesis—Kathrina Marcelo-Lewis

    Angiogenesis Regulators—Kathrina Marcelo-Lewis

    Targeting HIF-1α—Kathrina Marcelo-Lewis180

    Receptor Tyrosine Kinases—Kathrina Marcelo-Lewis

    VEGFR Signaling and Targeting VEGFR —Kathrina Marcelo-Lewis

    FGFR Signaling and Targeting FGFR—Kathrina Marcelo-Lewis

    Aberrations in FGFR Associated with Cancer—Kathrina Marcelo-Lewis

    Targeting the FGFR Pathway—Kathrina Marcelo-Lewis

    PDGFR and Targeting PDGFR—Jennifer Herold, Ecaterina Ileana-Dumbrava

    TIE Receptors—Ecaterina Ileana-Dumbrava

    IGFR-1 and Insulin Receptor— Ashley Perkins, Ecaterina Ileana-Dumbrava

    Targeting IGFR-1 and Insulin Receptor—Ashley Perkins, Ecaterina Ileana-Dumbrava

    TGFβ/SMAD Pathway—Ashley Perkins, Ecaterina Ileana-Dumbrava

    Targeting TGFβ/SMAD Pathway—Ashley Perkins, Ecaterina Ileana-Dumbrava

    EGFR Family of Receptors—Kavitha Balaji

    EGFR Signaling in Cancer—Kavitha Balaji

    EGFR Alterations—Kavitha Balaji

    Targeting EGFR—Kavitha Balaji

    HER2—Kavitha Balaji

    ERBB2/HER2 Alterations in Cancer—Kavitha Balaji

    Targeting HER2—Kavitha Balaji

    HGF Receptors: MET—Matthew Reilley

    Targeting MET—Matthew Reilley

    RET Receptor—Matthew Reilley

    ALK Receptor—Matthew Reilley

    ALK Alterations—Matthew Reilley

    KIT—Jennifer Herold

    Targeting KIT—Jennifer Herold

    ROS-1 Receptor—Matthew Reilley

    Targeting ROS-1—Matthew Reilley

    G-Protein–Coupled Receptors—Ed Kheder

    RAS/MAPK Pathway—Ed Kheder

    MAPK Pathway—Ed Kheder

    Targeting RAS—Ed Kheder

    Targeting BRAF—Ed Kheder

    Targeting MEK—Ed Kheder

    PI3K Pathway—Ana Stuckett

    PI3K–AKT–mTOR Pathway—Ana Stuckett

    Targeting PI3K Mutations—Ana Stuckett

    Targeting AKT Mutations—Ana Stuckett

    Targeting PTEN and TSC Alterations—Ana Stuckett

    Targeting mTORC1 and mTORC2—Ana Stuckett

    JAK/STAT Pathway—Le Huang

    Targeting JAK—Le Huang

    Hedgehog Signaling Pathway—Shhyam Moorthy

    NOTCH Pathway—Shhyam Moorthy

    Wnt Pathway—Shhyam Moorthy

    SRC Pathway—Shhyam Moorthy

    NFκb Pathway—Shhyam Moorthy

    Death Receptors and Apoptosis—Patrick Pilie

    Cell Cycle Regulation—Patrick Pilie

    TP53—Patrick Pilie

    RB1—Patrick Pilie

    CDKN2A—Patrick Pilie

    DNA Damage Response—Ecaterina Ileana-Dumbrava

    Targeting DNA Damage Response—Ecaterina Ileana-Dumbrava

    Aurora Kinases—Ecaterina Ileana-Dumbrava

    Immunotherapy—Hossein Maymani

    Targeting PD-1 and PD-L1—Hossein Maymani

    Immunotherapy—Hossein Maymani

    Targeting CTLA-4—Hossein Maymani

    Immunotherapy—Hossein Maymani

    Management of Immune-Related Diarrhea and Colitis—Kathrina Marcelo-Lewis, Ecaterina Ileana-Dumbrava

    Management of Immune-Related Hepatitis—Kathrina Marcelo-Lewis, Ecaterina Ileana-Dumbrava

    Management of Immune-Related Pneumonitis—Kathrina Marcelo-Lewis, Ecaterina Ileana-Dumbrava

    Management of Immune-Related Nephritis—Kathrina Marcelo-Lewis, Ecaterina Ileana-Dumbrava

    Management of Immune-Related Skin Rash/Toxicities—Kathrina Marcelo-Lewis, Ecaterina Ileana-Dumbrava

    Management of Immune-Related Peripheral Neurologic Toxicities—Kathrina Marcelo-Lewis, Ecaterina Ileana-Dumbrava

    Management of Immune-Related Thyroid Function Adverse Events—Kathrina Marcelo-Lewis, Ecaterina Ileana-Dumbrava

    Epigenetics—Le Huang

    Targeting Epigenetics in Cancer—Le Huang

    Antibody–Drug Conjugates—Roman Groisberg

    TRK Signaling Pathway—Sandra Montez

    Targeting Cancer Metabolism—Shiraj Sen

    Ewing Sarcoma Gene Fusion Partners—Daniel D. Karp

    Section 4 Targeted and Immunotherapy Agents

    Color Key

    Abbreviations

    Abiraterone Acetate (Zytiga)

    Acalabrutinib (Calquence)

    Ado-Trastuzumab Emtansine (Kadcyla)

    Afatinib Dimaleate (Gilotrif)

    Afuresertib

    Alectinib (Alecensa)

    Alemtuzumab (Campath-1h)

    Alisertib

    Alpelisib

    Apatinib

    Atezolizumab (Tecentriq)

    Avelumab (Bavencio)

    Axicabtagene Ciloleucel (Yescarta)

    Axitinib (Inlyta)

    Anetumab Ravtansine

    AZD-1775

    AZD9150

    Belinostat (Beleodaq)

    Bevacizumab (Avastin)

    BI 811283

    Bicalutamide (Casodex/Cosudex)

    Binimetinib

    Blinatumomab (Blincyto)

    BMS-936559

    Bortezomib (Velcade)

    Bosutinib (Bosulif)

    Brentuximab Vedotin (Adcetris)

    Brigatinib (Alunbrig)

    Brivanib Alaninate

    Buparlisib

    Cabozantinib (Cometriq)

    Carfilzomib (Kyprolis)

    Cediranib

    Ceritinib (Zykadia)

    Cetuximab (Erbitux)

    Cixutumumab

    Cobimetinib (Cotellic)

    Combretastatin Disodium

    Copanlisib (Aliqopa)

    Crizotinib (Xalkori)

    Dabrafenib (Tafinlar)

    Dacomitinib

    Dactolisib

    Daratumumab (Darzalex)

    Dasatinib (Sprycel)

    Denosumab (Xgeva)

    Dovitinib

    Durvalumab (Imfinzi)

    Elotuzumab (Empliciti)

    Enasidenib Mesylate (Idhifa)

    Encorafenib

    Enzalutamide (Xtandi)

    Epratuzumab

    Erlotinib (Tarceva)

    Everolimus (Afinitor)

    Farletuzumab

    Figitumumab

    Foretinib

    Fostamatinib Disodium

    Galunisertib

    Ganitumab

    Gefitinib (Iressa)

    Gemtuzumab Ozogamicin (Mylotarg)

    Idelalisib (Zydelig)

    Ibrutinib (Imbruvica)

    Imatinib Mesylate (Gleevec)

    INC280

    Iniparib

    Inotuzumab Ozogamicin

    Ipilimumab (Yervoy)

    Ivosidenib

    Lapatinib Ditosylate (Tykerb)

    Lenalidomide (Revlimid)

    Lenvatinib Mesylate (Lenvima)

    LGK974

    Linifanib

    Linsitinib

    Lonafarnib

    LOR-253 HCL

    Larotrectinib

    LOXO-292

    LY2157299

    Mocetinostat

    Mogamulizumab (Poteligeo)

    Masitinib Mesylate

    Matuzumab

    MEDI0639

    Midostaurin (Rydapt)

    Mirvetuximab Soravtansine

    MK-0752

    MK-2206

    MK-8242

    MKC-1

    MSC2156119J

    Navitoclax

    Necitumumab (Portrazza)

    Neratinib (Nerlynx)

    Nilotinib (Tasigna)

    Nimotuzumab

    Nintedanib

    Niraparib (Zejula)

    Nivolumab (Opdivo)

    Obinutuzumab (Gazyva)

    Ofatumumab (Arzerra)

    Olaparib (Lynparza)

    Omipalisib

    Olaratumab (Lartruvo)

    OMP-54F28

    Onartuzumab

    Orantinib

    Osimertinib (Tagrisso)

    Pacritinib

    Palbociclib (Ibrance)

    Panitumumab (Vectibix)

    Panobinostat

    Pazopanib Hydrochloride (Votrient)

    PEG-interferon alfa-2b (Sylatron)

    Pembrolizumab (Keytruda)

    Pemetrexed (Alimta)

    Perifosine

    Pertuzumab (Perjeta)

    PF-03814735

    Pilaralisib

    Pimasertib

    Pomalidomide (Pomalyst)

    Ponatinib Hydrochloride (Iclusig)

    Poziotinib

    Pralatrexate (Folotyn)

    PRI-724

    Quizartinib

    Ramucirumab (Cyramza)

    Refametinib

    Regorafenib (Stivarga)

    Reolysin

    Ridaforolimus

    Rigosertib

    Rilotumumab

    Rituximab (Rituxan)

    Romidepsin (Istodax)

    Rovalpituzumab Tesirine

    Rucaparib Camsylate (Rubraca)

    Ruxolitinib Phosphate (Jakafi)

    Salirasib

    Saracatinib

    Selinexor

    Selumetinib

    Sipuleucel-T (Provenge)

    Sirolimus (Rapamune)

    Sonidegib (Odomzo)

    Sonolisib

    Sorafenib (Nexavar)

    Sunitinib (Sutent)

    Talimogene Laherparepvec (Imlygic)

    Talazoparib

    Telatinib

    Temsirolimus (Torisel)

    Teprotumumab

    Tipifarnib

    Tisagenlecleucel (Kymriah)

    Tivantinib

    Trabectidin (Yondelis)

    Trabedersen

    Trametinib (Mekinist)

    Trastuzumab (Herceptin)

    Tremelimumab

    Triciribine

    Trebananib

    Trifluridine and Tipiracil (Lonsurf)

    Valproic Acid (Depakote)

    Vandetanib (Caprelsa)

    Vantictumab

    Vanucizumab

    Veliparib

    Vemurafenib (Zelboraf)

    Venetoclax (Venclexta)

    Vismodegib (Erivedge)

    Vocimagene Amiretrorepvec

    Vorinostat (Zolinza)

    Zalutumumab

    Ziv-Aflibercept (Zaltrap)

    Index

     

  • Oxford Handbook of Oncology (Oxford Medical Handbooks)
    Pe comanda in aproximativ 4 saptamani
    225.00 lei

    Now fully revised and in its fourth edition, the Oxford Handbook of Oncology has been the essential go-to guide for students and practitioners in oncology for over a decade. The scientific basis and diagnosis of cancers is covered, as well as drugs, biomarkers, and the presentation and psychosocial aspects of oncology. Concise, practical, and comprehensive, there is no better companion for both common conditions and challenging emergencies. The field of oncology has surged forward since the last edition was published and the Oxford Handbook of Oncology has been fully revised and updated to reflect these recent advances so you can be sure that the vital information you need is in your hands. This handbook incorporates changes such as the understanding of the science of cancer, novel therapies in breast, lung, renal, and melanoma, molecular sub-classification of common solid cancers, personalized therapy approaches, new agents in hard to treat cancers, the benefits of new technologies in radiotherapy, and the emerging data on the importance of the immune response. Written by experts in the field to ensure that it is grounded in real life clinical practice, this handbook provides a concise guide to all aspects of oncology for all students, nurses, and junior faculty responsible for the care of cancer patients, while also providing further reading and highlighting areas of controversy for those who need a more detailed understanding.

  • Molecular Biology of Cancer
    La comanda in aproximativ 4 saptamani
    24800lei 225.00 lei

    Lauren Pecorino

    • Provides an engaging and manageable route into the complex subject of cancer biology
    • Describes the theoretical basis of cancer biology and shows how this theory is applied to develop new cancer therapies, giving students a clear appreciation of how theoretical knowledge can be translated into therapeutic strategies
    • Draws on the latest research in this dynamic field but presents it in a manner readily accessible to the student

    New to this Edition:

    • New full colour diagrams help students to visualize the key concepts explained in the text more effectively
    • Expanded coverage of tumour immunology and immunotherapy, discussing tumour suppression and tumour promotion mechanisms of the immune system and the exciting new applications of this knowledge towards developing cancer immunotherapies

  • 230.00 lei

     

    Description:

    Understanding Cancer is a brand new undergraduate textbook for students without prior training in biology that integrates an introduction to cancer medicine with descriptions of the biological processes that go wrong to cause cancer’s onset and progression. It also highlights the human side of cancer with stories of patients and loved ones touched by the disease, dealing with diagnosis, treatment, and the prospect of death as well as the broader societal aspects of cancer and its prevention. Key discoveries that have improved our understanding of cancer are presented in sidebars. In spite of this diversity, the book maintains precision and simplicity in describing what is and is not known about cancer, describing the strengths and limitations of current treatments

     

    Table of Contents:

     

    Student and Instructor e-Resources

    Acknowledgments

    1 Cancer and the Biology of Human Cells

    Learning goals

    What is a cell? The basics

    When normal cells misbehave

    Current treatments of cancer and prospects for the future

    Summary

    Essential concepts

    Key terms

    Further reading

    Questions for further thought

    Answers to side questions

    2 Cancer Detection, Diagnosis, and Prognosis

    Learning goals

    Simple screens to identify potentially cancerous growths

    Characterizing a potentially cancerous lesion

    Modern instrumentation to image a patient’s insides

    Evaluating the results from cancer screening tests and medical imaging

    Cancer prognosis: understanding what a diagnosis means

    Summary

    Essential concepts

    Key terms

    Further reading

    Questions for further thought

    Answers to side questions

    3 The Organization of Normal Human Cells

    Learning goals

    How scientists study cell structure

    The structures of cellular macromolecules

    Macromolecules in the context of cell structure

    Protein fibers for cytoplasmic structure and function

    Regulating a cell’s many processes

    Summary

    Essential concepts

    Key terms

    Further readings

    Questions for further thought

    Answers to side questions

    4 How Normal Cells Reproduce and Differentiate

    Learning goals

    Cell growth and division cycles

    Cell differentiation as an alternative to cell growth and division

    Signaling between cells

    How cells cope with mistakes

    Checkpoints arrest cell cycle progression to improve the fidelity of cell reproduction

    Summary

    Essential concepts

    Key terms

    Further readings

    Questions for further thought

    Answers to side questions

    5 Factors that Promote the Cancerous Transformation of Cells

    Learning goals

    Carcinogenic radiation

    Carcinogenic chemicals

    Carcinogenic viruses

    Cancer risk through inheritance and lifestyle

    Summary

    Essential concepts

    Key terms

    Further readings

    Questions for further thought

    Answers to side questions

    6 Oncogenes and their Roles in Cancerous Transformation

    Learning goals

    Cancer transmission by certain animal viruses

    The discovery of oncogenes in cancer cells

    Pursuing the functions of oncogenes and their products

    The discovery of oncogenes through analysis of dna sequence

    The many genetic changes needed for cancerous transformations that lead to malignancy

    Changes that contribute to the immortality of cancer cells

    Summary

    Essential concepts

    Key terms

    Further readings

    Questions for further thought

    Answers to side questions

    7 Tumor Suppressors and their Roles in Resisting Cancerous Transformation

    Learning goals

    Dna repair as a cancer-inhibiting process

    Tumor suppression by regulators of cell cycle progression

    Cancer-inducing mutations and apoptosis

    It takes multiple mutations to complete a cancerous transformation

    Summary

    Essential concepts

    Key terms

    Further readings

    Questions for further thought

    Answers to side questions

    8 Medical Treatments for Cancer

    Learning goals

    Diagnostic methods set the stage for cancer treatment

    Surgery

    Radiation treatment

    Chemotherapy

    New chemotherapies from basic cancer research

    Alternative medicine and cancer

    Summary

    Essential concepts

    Key terms

    Further readings

    Questions for further thought

    Answers to side questions

    9 The Immune System and its Relationship to Cancer

    Learning goals

    Innate immunity

    Adaptive immunity

    Humoral adaptive immunity

    Cellular adaptive immunity

    The immune system and prevention of cancerous progression

    The immune system and cancer treatment

    Summary

    Essential concepts

    Key terms

    Further readings

    Questions for further thought

    Answers to side questions

    10 A Perspective on Cancer Futures

    Learning goals

    Progress in screening for and characterizing cancer

    Progress in cancer diagnosis

    Progress in cancer treatment

    New immunological approaches to cancer therapy

    Integrated approaches

    Can the costs for this kind of progress be borne, and will they be worth it?

    Summary

    Essential concepts

    Key terms

    Further readings

    Questions for further thought

    Answers to side questions

    11 Minimizing Cancer Risk

    Learning goals

    Chance as a component of cancer risk

    Inherited cancer risk and possible actions to reduce it

    Reducing the environmental component of cancer risk

    Diet and cancer risk

    Behavior and cancer risk

    Medical efforts to reduce cancer risk and problems with their implementation

    Summary

    Essential concepts

    Key terms

    Further readings

    Questions for further thought

    Answers to side questions

    12 Living with Cancer

    Learning goals

    Point of view

    A focus on life, not death

    Seeing cancer treatments for what they are

    Remission and the renewal of hope

    Coping with pain

    Dealing with physical weakness

    Choosing an environment

    Caring for cancer caregivers

    Summary

    Essential concepts

    Key terms

    Further readings

    Answers to side questions

    Glossary

    Index

     

  • 26200lei 235.00 lei

     

    Description:

    Brachytherapy is continuously advancing. Years of accumulated experience have led to clinical evidence of its benefit in numerous clinical sites such as gynecological, prostate, breast, rectum, ocular, and many other cancers. Brachytherapy continues to expand in its scope of practice and complexity, driven by strong academic and commercial research, by advances in competing modalities, and due to the diversity in the political and economic landscape. It is a true challenge for practicing professionals and students to readily grasp the overarching trends of the field, especially of those technologies and innovative practices that are not yet established but are certainly on the rise. Addressing this challenge, Emerging Technologies in Brachytherapy presents a comprehensive collection of chapters on the latest trending/emerging technologies and expert opinions. It is divided into five broad sections: Section I: Physics of Brachytherapy Section II: Imaging for Brachytherapy Guidance Section III: Brachytherapy Suites Section IV: Is Brachytherapy a Competitive Modality? Section V: Vision 20/20: Industry Perspective Each section has a carefully selected collection of chapters, which covers the spectrum of topics in comprehensive detail. By drawing on recognized experts and key opinion leaders from academia and commercial sectors worldwide (100 contributors), Emerging Technologies in Brachytherapy provides readers with a wealth of relevant information needed to comprehend the rapidly advancing technologies and trends of today and the prospects for the future.

     

    Table of Contents:

     

    Chapter 1: Introduction

    Section I: Physics of Brachytherapy

    Chapter 2: Sources and Loading Technologies

    Chapter 3: Applicators

    Chapter 4: Applicator Reconstruction

    Chapter 5: Dose Calculation

    Chapter 6: Dose Optimization

    Chapter 7: Image Processing for Brachytherapy

    Chapter 8: FMEA for Brachytherapy

    Chapter 9: Real-Time In Vivo Dosimetry

    Chapter 10: Quality Assurance Technologies

    Chapter 11: Additive Manufacturing (3D Printing) in Brachytherapy

    Chapter 12: Robotics in Brachytherapy

    Section II: Imaging for Brachytherapy Guidance

    Chapter 13: Optical Imaging and Navigation Technologies

    Chapter 14: Ultrasound

    Chapter 15: X-Ray and Computed Tomography

    Chapter 16: Magnetic Resonance Imaging

    Chapter 17: Positron Emission Tomography

    Chapter 18: Imaging for Treatment Verification

    Section III: Brachytherapy Suites

    Chapter 19: Medical University of Vienna, Vienna, Austria

    Chapter 20: University Medical Center Utrecht, Utrecht, the Netherlands

    Chapter 21: University Hospital Erlangen, Erlangen, Germany

    Chapter 22: Charles LeMoyne Hospital, Montreal, Canada

    Chapter 23: Sunnybrook Health Sciences Centre, Toronto, Canad

    Chapter 24: Princess Margaret Cancer Centre, Toronto, Canada

    Chapter 25: Tata Memorial Hospital, Mumbai, India

    Chapter 26: Institut Joliot-Curie Cancer Center, Dakar, Senegal: Implementing a Brachytherapy Program in a Resource Limited Setting

    Section IV: Is Brachytherapy a Competitive Modality?

    Chapter 27: EBRT or Brachytherapy?

    Chapter 28: Particle Therapy or Brachytherapy?

    Chapter 29: Is Brachytherapy Cost Effective?

    Section V: Vision 20/20: Industry Perspective

    Chapter 30: Elekta Brachytherapy

    Chapter 31: Eckert & Ziegler BEBIG

    Index

     

  • 240.00 lei

     

    Propelling quantitative MRI techniques from bench to bedside, Quantitative MRI in Cancer presents a range of quantitative MRI methods for assessing tumor biology. It includes biophysical and theoretical explanations of the most relevant MRI techniques as well as examples of these techniques in cancer applications.

    The introductory part of the book covers basic cancer biology, theoretical aspects of NMR/MRI physics, and the hardware required to form MR images. Forming the core of the book, the next three parts illustrate how to characterize tissue properties with endogenous and exogenous contrast mechanisms and discuss common image processing techniques relevant for cancer. The final part explores emerging areas of MR cancer characterization, including radiation therapy planning, cellular and molecular imaging, pH imaging, and hyperpolarized MR. Each of the post-introductory chapters describes the salient qualitative and quantitative aspects of the techniques before proceeding to preclinical and clinical applications. Each chapter also contains references for further study.

    Leading the way toward more personalized medicine, this text brings together existing and emerging quantitative MRI techniques for assessing cancer. It provides a self-contained overview of the theoretical and experimental essentials and state of the art in cancer MRI.

     

  • 240.00 lei

     

    In the field of radiobiology, the linear-quadratic (LQ) equation has become the standard for defining radiation-induced cell killing. Radiotherapy Treatment Planning: Linear-Quadratic Radiobiology describes tumor cell inactivation from a radiation physics perspective and offers appropriate LQ parameters for modeling tumor and normal tissue responses.

    The book compiles radiation mechanism information from biophysical publications of the past 50 years, addressing how ionizing radiation produces the killing of stem cells in human tumors. It presents several physical and chemical parameters that can modulate the radiation response of clonogenic cells in tumors. The authors describe the use of the LQ model in basic radiation mechanism studies with cells of relatively homogeneous radiation response and then extend the model to the fitting of survival data generated with heterogeneous cell populations (tumors). They briefly discuss how to use the LQ model for predicting tumor (local) control probability (TCP) and normal tissue complication probability (NTCP). The book also examines potential molecular targets related to alpha- and beta-inactivation and gives suggestions for further molecular characterizations of these two independent processes.

     

    Focusing on quantitative radiobiology in LQ formulation, this book assists medical physicists and radiation oncologists in identifying improved cancer treatments. It also encourages investigators to translate potentially improved radiotherapy schedules based on TCP and NTCP modeling into actual patient benefit.

     

  • 240.00 lei

     

    The first text to focus solely on quality and safety in radiotherapy, this work encompasses not only traditional, more technically oriented, quality assurance activities, but also general approaches of quality and safety. It includes contributions from experts both inside and outside the field to present a global view. The task of assuring quality is no longer viewed solely as a technical, equipment-dependent endeavor. Instead, it is now recognized as depending on both the processes and the people delivering the service. Divided into seven broad categories, the text covers:

     

    Quality Management and Improvement includes discussions about lean thinking, process control, and access to services.

     

    Patient Safety and Managing Error looks at reactive and prospective error management techniques.

     

    Methods to Assure and Improve Quality deals broadly with techniques to monitor, assure, and improve quality.

     

    People and Quality focuses on human factors, changing roles, staffing, and training.

     

    Quality Assurance in Radiotherapy addresses the general issues of quality assurance with descriptions of the key systems used to plan and treat patients and includes specific recommendations on the types and frequencies of certain tests.

    Quality Control: Equipment and Quality Control: Patient-Specific provides explicit details of quality control relating to equipment and patient-specific issues.

     

    Recently, a transformation of quality and safety in radiotherapy has begun to take place. Among the key drivers of this transformation have been new industrial and systems engineering approaches that have come to the forefront in recent years following revelations of system failures. This book provides an approach to quality that is long needed, one that deals with both human and technical aspects that must be the part of any overall quality improvement program.

     

  • 240.00 lei

     

    Description:

    This book explores outcome modeling in cancer from a data-centric perspective to enable a better understanding of complex treatment response, to guide the design of advanced clinical trials, and to aid personalized patient care and improve their quality of life. It contains coverage of the relevant data sources available for model construction (panomics), ranging from clinical or preclinical resources to basic patient and treatment characteristics, medical imaging (radiomics), and molecular biological markers such as those involved in genomics, proteomics and metabolomics. It also includes discussions on the varying methodologies for predictive model building with analytical and data-driven approaches. This book is primarily intended to act as a tutorial for newcomers to the field of outcome modeling, as it includes in-depth how-to recipes on modeling artistry while providing sufficient instruction on how such models can approximate the physical and biological realities of clinical treatment. The book will also be of value to seasoned practitioners as a reference on the varying aspects of outcome modeling and their current applications. Features: Covers top-down approaches applying statistical, machine learning, and big data analytics and bottom-up approaches using first principles and multi-scale techniques, including numerical simulations based on Monte Carlo and automata techniques Provides an overview of the available software tools and resources for outcome model development and evaluation, and includes hands-on detailed examples throughout Presents a diverse selection of the common applications of outcome modeling in a wide variety of areas: treatment planning in radiotherapy, chemotherapy and immunotherapy, utility-based and biomarker applications, particle therapy modeling, oncological surgery, and the design of adaptive and SMART clinical trials

     

     

    Table of Contents:

     

    Section I Multiple Sources of Data

    Chapter 1 ■ Introduction to data sources and outcome models

    1.1 Introduction to Outcome Modeling

    1.2 Model Definition

    1.3 Types of Outcome Models

    1.3.1 Prognostic versus predictive models

    1.3.2 Top-down versus bottom-up models

    1.3.3 Analytical versus data-driven models

    1.4 Types of Data Used in Outcome Models

    1.5 The Five Steps Towards Building an Outcome Model

    1.6 Conclusions

    Chapter 2 ■ Clinical data in outcome models

    2.1 Introduction

    2.2 Collagen Vascular Disease

    2.3 Genetic Studies

    2.4 Biological Factors Impacting Toxicity After Sbrt

    2.4.1 Chest wall toxicity after SBRT

    2.4.2 Radiation-induced lung toxicity (RILT) after SBRT

    2.4.3 Radiation-induced liver damage (RILD) after SBRT

    2.5 Big Data

    2.6 Conclusions

    Chapter 3 ■ Imaging data (radiomics)

    3.1 Introduction

    3.2 Image Features Extraction

    3.2.1 Static image features

    3.2.2 Dynamic image features

    3.3 Radiomics Examples from Different Cancer Sites

    3.3.1 Predicting local control in lung cancer using PET/CT

    3.3.2 Predicting distant metastasis in sarcoma using PET/MR

    3.4 Conclusions

    Chapter 4 ■ Dosimetric data

    4.1 Introduction

    4.2 Dose Volume Metrics

    4.3 Equivalent Uniform Dose

    4.4 Dosimetric Model Variable Selection

    4.4.1 Model order based on information theory

    4.4.2 Model order based on resampling methods

    4.5 A Dosimetric Modeling Example

    4.5.1 Data set

    4.5.2 Data exploration

    4.5.3 Multivariate modeling with logistic regression

    4.5.4 Multivariate modeling with machine learning

    4.5.5 Comparison with other known models

    4.6 Software Tools for Dosimetric Outcome Modeling

    4.7 Conclusions

    Chapter 5 ■ Pre-clinical radiobiological insights to inform modelling of radiotherapy outcome

    5.1 Variability in Response to Highly Standardized Radiotherapy

    5.2 Variation in Sensitivity to Radiation

    5.3 Understanding Dose-Response of Tissues and Organs

    5.4 Animal Models to Study Radiation Response

    5.5 Processes Governing Outcome

    5.6 Patient-Individual Factors / Co-Morbidity

    5.7 Use in Models

    5.8 Conclusion

    Chapter 6 ■ Radiogenomics

    6.1 Introduction

    6.2 Biomarkers and the World of “-Omics”

    6.2.1 Structural variations

    6.2.1.1 Single nucleotide polymorphisms (SNPs)

    6.2.1.2 Copy number variations (CNVs)

    6.2.2 Gene expression: mRNA, miRNA, lncRNA

    6.2.3 Protein expression

    6.2.4 Metabolites

    6.3 Resources for Biological Data

    6.4 Examples of Radiogenomic Modeling

    6.4.1 Prostate cancer

    6.4.2 Breast cancer

    6.4.3 Lung cancer

    6.5 Conclusions

    Section II Top-down Modeling Approaches

    Chapter 7 ■ Analytical and mechanistic modeling

    7.1 Introduction

    7.2 Track Structure and DNA Damage

    7.3 Linear-Quadratic Model

    7.4 Kinetic Reaction Rate Models

    7.4.1 Repair-misrepair and lethal-potentially-lethal models

    7.4.2 Refined models

    7.4.3 The Giant LOop Binary LEsion (GLOBE)

    7.4.4 Local Effect Model (LEM)

    7.4.5 Microdosimetric-kinetic model (MKM)

    7.4.6 The Repair-misrepair-fixation model

    7.5 Mechanistic Modeling of Stereotactic Radiosurgery (SRS) and Stereotactic Body Radiotherapy (SBRT)

    7.5.1 LQ limitations and alternative models

    7.6 Incorporating Biological Data to Describe and Predict Biological Response

    7.7 Conclusions

    Chapter 8 ■ Data driven approaches I: conventional statistical inference methods, including linear and logistic regression

    8.1 What is a Regression

    8.2 Linear Regression

    8.2.1 Mathematical formalism

    8.2.2 Estimation of regression coefficients

    8.2.3 Accuracy of coefficient estimates

    8.2.4 Rejecting the null hypothesis

    8.2.5 Accuracy of the model

    8.2.6 Qualitative predictors

    8.2.7 Including interactions between variables

    8.2.8 Linear regression: example

    8.3 Logistic Regression

    8.3.1 Modelling of qualitative (binary) response

    8.3.2 Mathematical formalism

    8.3.3 Estimation of regression coefficients

    8.3.4 Accuracy of coefficient estimates

    8.3.5 Rejecting the null hypothesis, testing the significance of a model

    8.3.6 Accuracy of the model

    8.3.7 Qualitative predictors

    8.3.8 Including interaction between variables

    8.3.9 Statistical power for reliable predictions

    8.3.10 Time consideration

    8.4 Model Validation

    8.4.1 Apparent validation

    8.4.2 Internal validation

    8.4.3 External validation

    8.5 Evaluation of an Extended Model

    8.6 Feature Selection

    8.6.1 Classical approaches

    8.6.2 Shrinking and regularization methods: LASSO

    8.6.3 Bootstrap methods

    8.6.4 Logistic regression: example

    8.7 Conclusions

    Chapter 9 ■ Data driven approaches II: Machine Learning

    9.1 Introduction

    9.2 Feature Selection

    9.2.1 Principal Component Analysis (PCA)

    9.2.1.1 When should you use them?

    9.2.1.2 Who has already used them?

    9.3 Flavors of Machine Learning

    9.3.1 Artificial Neural Networks

    9.3.1.1 The basics

    9.3.1.2 When should you use them?

    9.3.1.3 Who has already used them?

    9.3.2 Support Vector Machine

    9.3.2.1 The basics

    9.3.2.2 When should you use them?

    9.3.2.3 Who has already used them?

    9.3.3 Decision Trees and Random Forests

    9.3.3.1 The basics

    9.3.3.2 When should you use them?

    9.3.3.3 Who has already used them?

    9.3.4 Bayesian approaches

    9.3.4.1 The basics

    9.3.4.2 When should you use them?

    9.3.4.3 Who has already used them?

    9.4 Practical Implementation

    9.4.1 The data

    9.4.2 Model fitting and assessment

    9.5 Conclusions

    9.6 Resources

    Section III Bottom-up Modeling Approaches

    Chapter 10 ■ Stochastic multi-scale modeling of biological effects induced by ionizing radiation

    10.1 Introduction

    10.2 Particle Tracks: Physical Stage

    10.3 Particle Tracks: Physico-Chemical and Chemical Stage

    10.4 Multi-Scale DNA and Chromatin Models

    10.5 Induction of DNA and Chromatin Damage

    10.6 DNA Damage Response

    10.7 Modeling Beyond Single-Cell Level

    10.8 Conclusions

    Chapter 11 ■ Multi-scale modeling approaches: application in chemo– and immuno–therapies

    11.1 Introduction

    11.2 Medical Oncology Treatments

    11.2.1 From chemotherapy to molecular targeted agents

    11.2.2 Immunotherapy

    11.3 Modeling Types

    11.3.1 Continuum tumor modeling

    11.3.2 Discrete tumor modeling

    11.3.3 Hybrid tumor modeling

    11.4 Modeling Examples

    11.4.1 Modeling of chemotherapy

    11.4.2 Modeling of immunotherapy

    11.5 Software Tools for Multi-Scale Modeling

    11.6 Conclusions

    Section IV Example Applications in Oncology

    Chapter 12 ■ Outcome modeling in treatment planning

    12.1 Introduction

    12.1.1 Review of the history and dose-volume based treatment planning and its limitations

    12.1.2 Emerging dose-response modeling in treatment planning and advantages

    12.2 Dose-Response Models

    12.2.1 Generalized equivalent uniform dose (gEUD)

    12.2.1.1 Serial and parallel organ models

    12.2.2 Linear-Quadratic (LQ) Model

    12.2.3 Biological effective dose (BED)

    12.2.4 Tumor control probability (TCP) models

    12.2.5 Normal Tissue Complication Model (NTCP) models

    12.2.5.1 Lyman-Kutcher-Burman (LKB) model

    12.2.5.2 Relative seriality (RS) model

    12.2.5.3 Model parameters and Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC)

    12.2.6 Combined TCP/NTCP models –Uncomplicated tumor control model (UTCP or P+)

    12.3 Dose-Response Models for Stereotactic Body Radiotherapy (SBRT)

    12.3.1 Linear-Quadratic (LQ) model applied to SBRT

    12.3.2 Universal survival curve (USC) model

    12.3.3 Linear-Quadratic-Linear (LQL) model

    12.3.4 Regrowth model

    12.3.5 Dose limits for SBRT treatments

    12.4 Biological Models in Treatment Planning

    12.4.1 Plan evaluation

    12.4.2 Plan optimization

    12.4.3 Dose summation using biological models

    12.4.4 Selection of outcome models and model parameters

    12.5 Commercially Available Treatment Planning Systems (TPS) Employing Outcome Models

    12.5.1 Elekta Monaco system (Maryland Heights, MO)

    12.5.2 Philips Pinnacle system (Andover, MA)

    12.5.2.1 Sensitivity of model parameters

    12.5.3 Varian Eclipse system (Palo Alto, CA)

    12.5.3.1 Objective functions in plan optimization

    12.5.3.2 Plan evaluation

    12.5.3.3 Sensitivity of model parameters

    12.5.4 RaySearch RayStation (Stockholm, Sweden)

    12.5.4.1 Plan evaluation tools

    12.5.4.2 Plan optimization tools

    12.5.5 MIM (MIM Software Inc., Cleveland, OH)

    12.5.5.1 Plan summation

    12.5.5.2 Plan evaluation

    12.6 Conclusions

    Chapter 13 ■ A utility based approach to individualized and adaptive radiation therapy

    13.1 Introduction

    13.2 Background

    13.2.1 Treatment planning in radiation therapy

    13.2.2 Biomarkers in RT

    13.3 Utility Approach to Plan Optimization

    13.3.1 In phase I trials

    13.3.2 In RT treatment planning

    13.3.3 Choice of the tradeoff parameter

    13.3.4 Virtual clinical trial

    13.4 Conclusions

    Chapter 14 ■ Outcome modeling in Particle therapy

    14.1 How are Particles Different from Photons?

    14.2 Linear Energy Transfer (LET)

    14.2.1 Dose averaging, track averaging and limitations

    14.3 Relative Biological Effectiveness

    14.3.1 The 1.1 conundrum in proton therapy

    14.3.2 LET based RBE models

    14.3.3 Non-LET based

    14.3.3.1 Track structure (δ-ray) model

    14.3.4 Uncertainties

    14.4 The Role of Monte Carlo

    14.4.1 Understanding dose and LET distributions

    14.4.1.1 Range uncertainties

    14.4.1.2 Considerations for dose and DVH

    14.4.1.3 LET

    14.4.2 RBE modeling

    14.4.3 Example MC simulations using TOPAS

    14.4.3.1 2-spot pencil setup

    14.4.3.2 Expansion to include patient setup, dose, LET and one RBE scorer

    14.5 Implications of Particle Therapy for Outcome Models

    14.5.1 Target effects

    14.5.2 Normal Tissue effects

    14.6 Application in Treatment Planning

    14.6.1 Vision for the future

    Chapter 15 ■ Modeling response to oncological surgery

    15.1 Introduction to Oncological Surgery

    15.1.1 Clinical and surgical factors modifying patients’ outcomes

    15.1.2 Complementary therapies to oncological surgery

    15.2 Modeling of Oncological Surgery

    15.2.1 Computational oncology models

    15.2.2 Mechanistic models from physical oncology

    15.2.2.1 Relevant variables

    15.2.2.2 Implemented models

    15.3 Example: A Bidimensional Oncological Surgery Simulation Model

    15.3.1 Step 1: diffusion of nutrients

    15.3.2 Step 2: CA rules and tumor growth constrained by the nutrients concentration and immune system response

    15.3.3 Step 3: surgery

    15.4 Discussion

    15.5 Conclusions and Perspectives

    15.6 Appendix 1: R Code

    Chapter 16 ■ Tools for the precision medicine era: developing highly adaptive and personalized treatment recommendations using SMARTs

    16.1 Introduction

    16.2 Studying Treatments in Sequence

    16.2.1 Adaptive treatment strategies

    16.2.2 Decision rules

    16.2.3 Tailoring variables are key for personalized recommendations

    16.2.4 Machine learning “teaches” us the optimal ATS

    16.3 Comparison to Traditional Methods

    16.3.1 Why might RCTs fail to identify good treatment sequences?

    16.3.2 Why can’t we combine results from separate, single-stage RCTs?

    16.3.3 What are the advantages of SMARTs?

    16.3.4 Motivating example

    16.4 Validating a Proposed ATS

    16.4.1 If we find an optimal ATS with a SMART, do we still need an RCT?

    16.4.2 Are SMARTs used in cancer?

    16.5 Challenges and Opportunities

    Bibliography

    Index

     

     

  • Paediatric Palliative Medicine
    La comanda in aproximativ 4 saptamani
    250.00 lei

    Looking after children with life-limiting conditions is very difficult for both parents and health care professionals. This second edition of Paediatric Palliative Medicine is full of easily-accessible, detailed information , and covers all aspects of the care of children with life-limiting illnesses. It is designed to equip clinicians with the knowledge, and its evidence base, to improve clinical care.

    Using the bestselling Oxford Specialist Handbook format to deliver practical and concise information, this handbook facilitates bedside delivery of effective palliative medicine to children. It includes a quick reference drug formulary and detailed information on medical conditions and symptom control. There are also specific management plans to guide professionals, whether the child is in their own home, in a hospital, or a hospice.

    Many children with long term conditions have symptoms which need management, and the principles of palliative care for children need to be known by all who are involved in their care. The unique significance of this handbook is its capacity to guide professionals who have not trained or had experience of caring for the dying child, as well as for students and trainees interested in paediatric palliative care.

    Children's palliative medicine encompasses symptom control but is not limited to it. This handbook also provides a wealth of information on the philosophy and models that support delivery of palliative medicine to children, as well as the learning and coping skills required in palliative care.

    Fully updated with an expanded formulary and a new chapter on the intensive care unit, this new edition continues to be the authoritative reference tool in paediatric palliative care.

  • 260.00 lei

     

    Reflecting the increased importance of the collaborations between radiation oncology and informatics professionals, Informatics in Radiation Oncology discusses the benefits of applying informatics principles to the processes within radiotherapy. It explores how treatment and imaging information is represented, stored, and retrieved as well as how this information relates to other patient data. The book deepens your knowledge of current and emerging information technology and informatics principles applied to radiation oncology so that all the data gathered―from laboratory results to medical images―can be fully exploited to make treatments more effective and processes more efficient.

    After introducing the basics of informatics and its connection to radiation oncology, the book examines the process of healthcare delivery in radiation oncology, the challenges of managing images in radiotherapy, and the burgeoning field of radiogenomics. It then presents teaching, clinical trials, and research tools and describes open access clinical imaging archives in radiotherapy, techniques for maximizing information from multimodality imaging, and the roles of images in treatment planning. It also looks at how informatics can improve treatment planning, the safety and efficiency of delivery systems, image-guided patient positioning, and patient assessment. The book concludes with discussions on how outcomes modeling evaluates the effectiveness of treatments, how quality control informatics improves the reliability of processes, and how to perform quality assurance on the informatics tools.


    With contributions from a host of top international experts in radiation oncology, medical physics, and informatics, this book leads the way in moving the field forward. It encourages you to find new ways of applying informatics to radiation oncology and help your patients in their fight against cancer.

     

  • 31000lei 260.00 lei

     

    Description:

    Offering expert guidance from seasoned clinicians at Massachusetts General Hospital, this bestselling handbook provides accurate, clinically essential information in a portable, quick-reference format. Broad-based, multidisciplinary coverage draws from the disciplines of anesthesiology, neurology, behavioral medicine, nursing, psychiatry, and physical therapy to provide practical, evidence-based information for sound therapeutic choices. Now in full color for the first time, The Massachusetts General Hospital Handbook of Pain Management, Fourth Edition, contains numerous new chapters, new illustrations, and other features that keep you up to date with today’s latest approaches to pain management.

     

     

    Table of Contents:

     

    SECTION I: GENERAL CONSIDERATIONS

    1 Neurophysiologic Basis of Pain

    I. PRIMARY SOMATOSENSORY NEURONS

    A. Definitions

    B. Nerve Fiber Types

    C. Nociceptors

    D. Peripheral Sensitization

    II. SPINAL CORD AND DORSAL HORN SYNAPTIC TRANSMISSION

    A. Dorsal Horn Laminar Organization

    B. Dorsal Horn Neurotransmission

    C. Central Sensitization

    III. SUPRASPINAL PAIN PROCESSING

    A. Ascending Nociceptive Tracts

    B. Brain Centers

    IV. DESCENDING PROJECTIONS

    A. Descending Systems

    B. Neurotransmitters Involved in Descending Modulation

    V. CONCLUSION

    2 Pain Mechanisms and Their Importance in Clinical Practice and Research

    I. CANONICAL NOCICEPTION PATHWAY

    II. PAIN ONTOLOGY AND PATIENT SYMPTOMOLOGY

    III. MECHANISMS OF PATHOLOGICAL PAIN

    A. Peripheral Sensitization

    B. Peripheral Respecification

    C. Synaptic Potentiation

    D. Synaptic Sprouting

    E. Opening the Gate

    1. Inhibitory Interneuron Death

    2. Modification of Chloride Gradient

    F. Descending Pain Control

    G. Encoding Pain in the Brain

    IV. TOWARD MECHANISM-BASED DIAGNOSIS AND THERAPY

    A. Genetics of Pain Mechanisms

    V. IMPLICATIONS FOR EVALUATION OF NEW THERAPIES

    VI. CONCLUSION

    3 Ethics of Pain Management

    I. ETHICAL FRAMEWORKS

    A. Four Principles

    1. Nonmaleficence

    2. Beneficence

    3. Autonomy

    4. Justice

    B. Four-Quadrant Approach

    1. Indications for Medical Intervention

    2. Patient Preferences

    3. Quality of Life

    4. Contextual Features

    C. CARE

    1. Core Beliefs: Interior Individual

    2. Actions: Exterior Individual

    3. Reasons: Interior Collective

    4. Experience: Exterior Collective

    D. Microethics

    1. Respecting and Constructing Patient Values and Preferences

    2. Self-awareness and Management of Clinician Values and Biases

    3. Managing Medical Information

    II. EXAMPLES OF ETHICAL APPLICATIONS IN PAIN MEDICINE

    A. Nonopioid Pharmacologic Options

    1. Case

    2. Discussion

    B. Opioids and Interventions

    1. Case

    2. Discussion

    III. CONCLUSIONS

    SECTION II: DIAGNOSIS OF PAIN

    4 The History and Clinical Examination

    I. PATIENT INTERVIEW

    A. Pain History

    1. Development and Timing

    2. Intensity

    3. Character

    4. Evolution

    5. Associated Symptoms

    6. Aggravating and Relieving Factors

    7. Previous Treatment

    B. Medical History

    1. Review of Systems

    2. Past Medical History

    3. Past Surgical History

    C. Drug History

    1. Current Medications

    2. Allergies

    D. Social History

    1. General Social History

    2. Family History

    3. Occupational History

    II. PATIENT EXAMINATION

    A. General Examination

    1. Constitutional Factors

    2. Pain Behavior

    3. Skin

    B. System Examination

    1. Cardiovascular System

    2. Lungs

    3. Musculoskeletal System

    C. Specific Tests

    1. Straight Leg Raising (SLR, Lasègue)

    2. Basic Sacroiliac Tests

    3. Spinal Flexibility

    4. Adson Test

    5. Neurologic Examination

    6. Mental Status Examination

    III. INCONSISTENCIES IN THE HISTORY AND PHYSICAL EXAMINATION

    IV. CONCLUSION

    5 Assessment of Pain

    I. PAIN HISTORY

    A. Pain Assessment Tools

    1. Unidimensional Self-report Scales

    2. Multiple Dimension Instruments

    3. Pain Diaries

    B. Pain Location

    C. Pain Etiology

    1. Types of Pain

    II. PHYSICAL EXAMINATION

    A. General Physical Examination

    B. Specific Pain Evaluation

    C. Neurologic Examination

    D. Sensory Testing

    E. Musculoskeletal System Examination

    F. Assessment of Psychological Factors

    III. DIAGNOSTIC STUDIES

    IV. CONCLUSION

    6 Psychological Assessment of Pain and Headache

    I. THE BIOPSYCHOSOCIAL MODEL OF PAIN ASSESSMENT

    II. PSYCHOLOGICAL RISK SCREENING VS COMPREHENSIVE PSYCHOSOCIAL ASSESSMENT

    III. THE PROGRESSION FROM ACUTE TO CHRONIC PAIN CONDITIONS

    IV. COMMON PSYCHOLOGICAL COMORBIDITIES WITH CHRONIC PAIN

    V. PAIN BEHAVIORS

    VI. STANDARDIZED MEASURES

    VII. SELF-REPORT MEASURES

    VIII. OBSERVATIONAL MEASURES

    IX. BEHAVIORAL ASSESSMENT FOR EFFECTIVE GOAL SETTING

    X. BARRIERS AND STIGMA ASSOCIATED WITH PSYCHOLOGICAL ASSESSMENT

    XI. SPECIAL CONSIDERATIONS FOR INDIVIDUALS RECEIVING CHRONIC OPIOID THERAPY

    XII. SPECIAL CONSIDERATIONS FOR WORK-INJURED POPULATIONS

    XIII. KEY POINTS

    7 Diagnostic Imaging and Pain Management

    I. OVERVIEW

    II. IMAGING TECHNIQUES AND STUDIES

    A. Plain Films

    B. Fluoroscopy

    C. Computed Tomography

    D. Magnetic Resonance Imaging

    E. Myelography

    F. Bone Scans and Nuclear Medicine

    G. Discography

    H. Positron Emission Tomography

    I. Functional Magnetic Resonance Imaging

    III. HEADACHE

    A. Primary Headache

    B. Secondary Headache

    IV. CRANIOFACIAL PAIN SYNDROMES

    A. Trigeminal Neuralgia

    B. Glossopharyngeal Neuralgia

    V. CENTRAL PAIN SYNDROMES

    VI. THALAMIC PAIN SYNDROMES

    VII. SPINAL CORD INJURY

    A. Axial Low Back Pain

    B. Plain X-ray Evaluation of Low Back Pain

    C. MRI and Low Back Pain

    D. Pain After Lumbar Surgery

    E. Arachnoiditis

    VIII. METASTATIC DISEASE OF THE SPINE

    IX. INFECTIOUS PROCESSES OF THE VERTEBRAL SPINE

    X. CONCLUSION

    8 Neurophysiologic Testing in Pain Management

    I. INTRODUCTION

    II. ELECTRODIAGNOSTIC TESTING

    A. Nerve Conduction Studies

    B. Needle Electrode Examination

    C. Localizing a Nerve Injury

    D. Aiding in Diagnosis

    E. Clinical Applications

    III. QUANTITATIVE SENSORY TESTING

    A. Thermal Stimuli

    B. Vibration Stimuli

    C. Mechanical Stimuli

    D. Electrical Stimuli

    IV. EVOKED POTENTIALS

    A. Somatosensory Evoked Potentials

    B. Laser Evoked Potentials

    V. AUTONOMIC TESTING

    VI. CONCLUSION

    9 Disability Assessment

    I. BURDEN OF DISABILITY ASSOCIATED WITH PAIN

    II. WHY PROVIDERS ARE ASKED TO ASSESS DISABILITY

    III. KEY INSIGHTS ON ASSESSING DISABILITY

    IV. HOW TO ASSESS DISABILITY

    A. Preparation

    B. Face-to-Face Interview

    C. Functional Assessment

    D. Document Observations, Answer Specific Questions, and Develop Report

    V. PITFALLS OF FORMAL FUNCTIONAL CAPACITY EVALUATIONS

    VI. MALINGERING AND NONMEDICAL INFORMATION

    VII. CONCLUSION

    SECTION III: THERAPEUTIC OPTIONS: PHARMACOLOGIC APPROACHES

    10 Neuropathic Pain Medications

    I. ANTIDEPRESSANTS

    II. TRICYCLIC ANTIDEPRESSANTS

    A. Mechanism of Action

    B. Pharmacology

    C. Dosing and Monitoring

    D. Adverse Side Effects

    E. Indications and Evidence

    III. SELECTIVE SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITORS

    A. Mechanism of Action

    B. Pharmacology

    C. Dosing and Monitoring

    D. Adverse Side Effects

    E. Indications and Evidence

    IV. SELECTIVE SEROTONIN REUPTAKE INHIBITORS

    A. Mechanism of Action

    B. Pharmacology

    C. Dosing and Monitoring

    D. Adverse Side Effects

    E. Indications and Evidence

    V. OTHER MEDICATIONS

    A. Trazodone

    1. Mechanism of Action

    2. Pharmacology

    3. Dosing and Monitoring

    4. Adverse Side Effects

    5. Indications and Evidence

    B. Mirtazapine

    1. Mechanism of Action

    2. Pharmacology

    3. Dosing and Monitoring

    4. Adverse Side Effects

    5. Indications and Evidence

    C. Bupropion

    1. Mechanism of Action

    2. Pharmacology

    3. Dosing and Monitoring

    4. Adverse Side Effects

    5. Indications and Evidence

    D. Ketamine

    1. Mechanism of Action

    2. Pharmacology

    3. Dosing and Monitoring

    4. Adverse Side Effects

    5. Indications and Evidence

    VI. CALCIUM CHANNEL BLOCKERS

    A. Gabapentin

    1. Mechanism of Action

    2. Pharmacology

    3. Dosing and Monitoring

    4. Adverse Side Effects

    5. Indications and Evidence

    B. Pregabalin

    1. Mechanism of Action

    2. Pharmacology

    3. Dosing and Monitoring

    4. Adverse Side Effects

    5. Indications and Evidence

    C. Ziconotide

    1. Mechanism of Action

    2. Pharmacology

    3. Dosing and Monitoring

    4. Adverse Side Effects

    5. Indications and Evidence

    D. Zonisamide

    1. Mechanism of Action

    2. Pharmacology

    3. Dosing and Monitoring

    4. Adverse Side Effects

    5. Indications and Evidence

    VII. ANTICONVULSANTS

    A. Carbamazepine

    1. Mechanism of Action

    2. Pharmacology

    3. Dosing and Monitoring

    4. Adverse Side Effects

    5. Indications and Evidence

    B. Oxcarbazepine

    1. Mechanism of Action

    2. Pharmacology

    3. Dosing and Monitoring

    4. Adverse Side Effects

    5. Indications and Evidence

    C. Lamotrigine

    1. Mechanism of Action

    2. Pharmacology

    3. Dosing and Monitoring

    4. Adverse Side Effects

    5. Indications and Evidence

    D. Topiramate

    1. Mechanism of Action

    2. Pharmacology

    3. Dosing and Monitoring

    4. Adverse Side Effects

    5. Indications and Evidence

    E. Lithium

    F. Phenytoin

    1. Mechanism of Action

    2. Pharmacology

    3. Dosing and Monitoring

    4. Adverse Side Effects

    5. Indications and Evidence

    VIII. LOCAL ANESTHETICS

    A. Lidocaine

    1. Mechanism of Action

    2. Pharmacology

    3. Dosing and Monitoring

    4. Adverse Side Effects

    5. Indications and Evidence

    B. Mexiletine

    1. Mechanism of Action

    2. Pharmacology

    3. Dosing and Monitoring

    4. Adverse Side Effects

    5. Indications and Evidence

    IX. NEUROLEPTICS

    A. Typical

    1. Mechanism of Action

    2. Pharmacology

    3. Adverse Side Effects

    4. Indications and Evidence

    B. Atypical

    1. Mechanism of Action

    2. Pharmacology

    3. Adverse Side Effects

    4. Indications and Evidence

    C. Capsaicin

    1. Mechanism of Action

    2. Pharmacology

    3. Dosing and Monitoring

    4. Adverse Side Effects

    5. Indications and Evidence

    11 Opioids

    I. DEFINITIONS

    A. Addiction

    B. Physical Dependence

    C. Tolerance

    D. Opium

    E. Opioid

    F. Opiate

    G. Narcotic

    H. Opioid-Induced Hyperalgesia

    II. HISTORY

    III. OPIOID CRISIS

    IV. MECHANISM OF ACTION

    V. DURATION OF TREATMENT

    VI. OPIOID RISK STRATIFICATION

    VII. COMMON OUTPATIENT OPIOIDS

    A. Buprenorphine

    B. Codeine

    C. Fentanyl

    D. Hydrocodone

    E. Hydromorphone

    F. Morphine

    G. Oxycodone

    H. Methadone

    I. Tramadol

    VIII. DIALYSIS-DEPENDENT PATIENTS

    IX. SIDE EFFECTS

    A. Endocrine Effects

    B. Falls Risks

    X. FUTURE OF OPIOIDS

    12 Nonsteroidal Anti-inflammatory Medications

    I. MECHANISM OF ACTION

    II. PHARMACOKINETICS

    III. ADVERSE EFFECTS

    A. Gastrointestinal Side Effects

    B. Cardiovascular Side Effects

    C. Hematologic Side Effects

    D. Renal and Hepatic Side Effects

    E. Miscellaneous Side Effects

    IV. SPECIFIC MEDICATIONS

    A. Acetaminophen

    13 Psychopharmacology for the Pain Specialist

    I. ANTIDEPRESSANTS

    A. Tricyclic Antidepressants

    1. Indications

    2. Mechanisms

    3. Adverse Effects

    4. Dosages and Monitoring

    B. Selective Serotonin Reuptake Inhibitors

    1. Indications

    2. Mechanisms

    3. Adverse Reactions

    4. Dosages and Monitoring

    C. Serotonin-NE Reuptake Inhibitors

    1. Indications

    2. Mechanisms

    3. Adverse Reactions

    4. Dosages and Monitoring

    D. Atypical Antidepressants

    1. Indications

    2. Mechanisms

    3. Adverse Reactions

    4. Dosages and Monitoring

    II. ANTIEPILEPTIC AGENTS (ANTICONVULSANTS)/MOOD STABILIZERS

    A. Indications

    B. Mechanisms

    C. Adverse Reactions

    D. Dosages and Monitoring (Table 13.6)

    III. ANXIOLYTICS

    A. Indications

    B. Mechanisms

    C. Adverse Reactions

    1. Dosages and Monitoring

    IV. ANTIPSYCHOTICS

    A. Indications

    B. Mechanisms

    C. Adverse Reactions

    D. Dosages and Monitoring

    V. PSYCHOSTIMULANTS

    A. Indications

    B. Mechanisms

    C. Adverse Reactions

    D. Dosages and Monitoring

    VI. CONCLUSIONS

    SECTION IV: THERAPEUTIC OPTIONS: INTERVENTIONAL APPROACHES

    14 Epidural Steroid Injection

    I. EFFICACY

    A. Evidence of Efficacy

    B. Mechanisms of Efficacy

    II. GENERAL PRINCIPLES

    A. Choice of Injectate

    1. Corticosteroids

    2. Local Anesthetic

    B. Physiologic Effects of Corticosteroids and Epidural Steroid Injections

    1. Immunosuppression

    2. Elevation of Blood Glucose

    3. Suppression of the Hypothalamic-Pituitary-Adrenal Axis

    4. Bone Demineralization

    C. Complications

    III. PROCEDURAL CONSIDERATIONS

    A. Preprocedure Management

    B. Contrast Media

    C. Postprocedure Management

    D. Lumbar and Cervical Interlaminar Approach

    E. Lumbar Transforaminal Approach

    F. Posterior S1 Foramen Approach

    G. Caudal Approach

    15 Radiofrequency Procedures for Chronic Pain

    I. TYPES OF RFA

    II. FACET JOINTS

    III. SACROILIAC JOINT

    IV. DORSAL ROOT GANGLIA

    V. HIP

    VI. KNEE

    VII. OCCIPITAL NERVES

    VIII. TRIGEMINAL NERVE

    IX. SYMPATHETIC GANGLIA

    X. CONCLUSIONS

    16 Sympathetic Blocks

    I. LUMBAR SYMPATHETIC BLOCK

    A. Anatomy

    B. Indications

    C. Technique

    D. Complications

    II. STELLATE GANGLION BLOCK

    A. Anatomy

    B. Indications

    C. Technique

    D. Complications

    III. CELIAC PLEXUS BLOCK

    A. Anatomy

    B. Indications

    C. Technique

    D. Complications

    IV. SUPERIOR HYPOGASTRIC BLOCK

    A. Anatomy

    B. Indications

    C. Techniques

    D. Complications

    V. GANGLION IMPAR BLOCK

    A. Anatomy

    B. Indications

    C. Technique

    D. Complications

    17 Lumbar Diskography and Intradiscal Treatments

    I. PROVOCATION DISKOGRAPHY/DISK STIMULATION

    A. Definitions

    B. Patient Selection

    C. Contraindications

    D. Procedure

    E. Level Determination

    F. Needle Positioning

    G. Disk Stimulation

    II. INTRADISCAL INTERVENTION PROCEDURES

    III. PERCUTANEOUS DISK DECOMPRESSION

    A. Intradiscal Electrothermal Therapy

    B. Nucleoplasty

    C. Biacuplasty

    18 Spinal Cord Stimulation

    I. MECHANISM OF ACTION

    II. INDICATIONS AND EVIDENCE

    III. TECHNICAL CONSIDERATIONS

    IV. COMPLICATIONS

    V. FUTURE DIRECTIONS

    19 Peripheral Nerve Blocks

    I. OCCIPITAL NERVE BLOCK

    A. Indications

    B. Equipment and Position

    C. Technique

    D. Complications

    E. Considerations

    II. TRIGEMINAL NERVE BRANCH BLOCKS

    A. Indications

    B. Equipment and Position

    C. Technique

    1. Pain in Ophthalmic (V1) Division

    2. Pain in Maxillary (V2) and Mandibular (V3) Divisions

    D. Complications

    E. Considerations

    III. SPHENOPALATINE GANGLION BLOCK

    A. Indications

    B. Equipment

    C. Technique

    D. Complications

    E. Considerations

    IV. SUPRASCAPULAR NERVE BLOCK

    A. Indications

    B. Equipment

    C. Techniques

    1. Landmark Technique

    2. Fluoroscopically Guided Technique

    3. Ultrasound Guided Technique

    D. Complications

    E. Considerations

    V. INTERCOSTAL NERVE BLOCK

    A. Indications

    B. Equipment and Position

    C. Technique

    1. Landmark Technique

    2. Fluoroscopy Guided Technique

    3. Ultrasound Guided Technique

    D. Specific Complications

    E. Considerations

    VI. ILIOINGUINAL AND ILIOHYPOGASTRIC NERVE BLOCK

    A. Indications

    B. Equipment

    C. Technique

    1. Landmark Technique

    2. Ultrasound Guided Technique

    D. Complications

    E. Considerations

    VII. PUDENDAL NERVE BLOCK

    A. Indications

    B. Equipment

    C. Technique

    D. Specific Complications

    E. Considerations

    VIII. LATERAL FEMORAL CUTANEOUS NERVE BLOCK

    A. Indications

    B. Equipment

    C. Technique

    1. Landmark Technique

    2. Ultrasound Guided Technique

    D. Complications

    E. Considerations

    IX. GENICULAR NERVE BLOCK

    A. Indications

    B. Equipment

    C. Technique

    D. Complications

    E. Considerations

    20 Implanted Spinal Drug Delivery Systems

    I. MECHANISM OF ACTION

    II. OVERVIEW OF IT PHARMACOLOGY

    A. Morphine

    B. Hydromorphone

    C. Fentanyl and Sufentanil

    D. Bupivacaine

    E. Clonidine

    F. Ziconotide

    III. PATIENT SELECTION

    IV. NONPHARMACOLOGICAL COMPLICATIONS

    V. CONCLUSIONS

    21 Infusion Therapies

    I. LIDOCAINE AND MEXILETINE

    A. Mechanism of Action and Pharmacology

    B. Uses in Specific Populations

    C. Dosing

    D. Routes of Administration

    E. Adverse Effects

    II. KETAMINE INFUSION

    A. Mechanism of Action and Pharmacology

    B. Uses in Specific Populations

    C. Dosing

    D. Routes of Administration

    E. Adverse Effects

    III. DEXMEDETOMIDINE INFUSION

    A. Mechanism of Action and Pharmacology

    B. Uses in Specific Populations

    C. Dosing

    D. Routes of Administration

    E. Adverse Effects

    IV. BISPHOSPHONATE INFUSION

    A. Mechanism of Action and Pharmacology

    B. Uses in Specific Populations

    C. Dosing

    D. Routes of Administration

    E. Adverse Effects

    V. PHENTOLAMINE

    A. Mechanism of Action and Pharmacology

    B. Uses in Specific Populations

    C. Dosing

    D. Routes of Administration

    E. Adverse Effects

    22 Neurosurgical Interventions for Pain

    I. GENERAL CONSIDERATIONS

    A. Timing and Patient Selection

    B. Treatment Modalities

    II. TRIGEMINAL NEURALGIA

    A. Diagnostic Considerations

    B. Microvascular Decompression

    C. Percutaneous Treatments

    D. Radiosurgery

    III. SPINAL INTERVENTIONS FOR NEUROPATHIC PAIN

    A. Dorsal Root Entry Zone Lesioning

    B. Spinal Cord Stimulation

    IV. CANCER PAIN

    A. Cordotomy

    B. Implantable Drug Delivery Pumps

    V. AFFECTIVE PAIN

    A. Cingulotomy

    VI. NEUROMODULATION FOR PAIN

    A. Deep Brain Stimulation

    B. Motor Cortex Stimulation

    VII. CONCLUSIONS

    23 Complications Associated With Interventional Pain Treatment

    I. OVERVIEW

    II. COMPLICATIONS ASSOCIATED WITH EPIDURAL, FACET JOINT, AND SACROILIAC INJECTION

    A. Neurotoxicity

    B. Neurologic Injury

    III. PHARMACOLOGIC EFFECTS OF CORTICOSTEROIDS

    IV. BLEEDING COMPLICATIONS

    V. INFECTIOUS COMPLICATIONS

    VI. COMPLICATIONS ASSOCIATED WITH TRANSFORAMINAL INJECTIONS

    VII. COMPLICATIONS ASSOCIATED WITH IMPLANTABLE DEVICES

    24 Fluoroscopy and Radiation Safety

    I. OVERVIEW

    II. BASIC RADIATION PHYSICS

    III. MINIMIZING PATIENT RADIATION EXPOSURE

    A. Minimize Dose and Time

    B. Optimize the Position of the X-ray Tube

    C. Employ Shielding Whenever Possible

    D. Employ Collimation

    IV. MINIMIZING PRACTITIONER EXPOSURE

    A. Employ Proper Shielding

    B. Practitioner Position

    C. Optimizing Image Quality

    25 Outcome Data and Interventional Pain Medicine

    I. INTRODUCTION

    II. TYPES OF OUTCOME DATA

    III. CHARACTERISTICS OF OUTCOME DATA

    IV. BIAS IN OUTCOME DATA

    V. SPECIAL FEATURES OF OUTCOME DATA IN PAIN MEDICINE

    VI. OUTCOME MEASUREMENT IN SPECIAL POPULATIONS

    VII. OUTCOME DATA FOR PAIN

    VIII. CONCLUSIONS

    SECTION V: THERAPEUTIC OPTIONS: NONPHARMACOLOGIC/NONINTERVENTIONAL APPROACHES

    26 Behavioral Treatments for Chronic Pain

    I. INTRODUCTION

    II. HISTORY

    A. Operant Behavioral

    B. Cognitive-Behavioral Therapy

    C. Mindfulness- and Acceptance-Based Treatments

    III. DSM-5 CHANGES: SOMATIC SYMPTOM DISORDER

    IV. PSYCHOLOGICAL FACTORS THAT IMPACT PAIN AND FUNCTION

    V. BEHAVIORAL HEALTH INTERVENTION FOR PATIENTS UTILIZING OPIOID MEDICATIONS

    VI. OPERANT BEHAVIORAL THERAPY

    VII. COGNITIVE-BEHAVIORAL THERAPY

    VIII. MINDFULNESS MEDITATION

    IX. ACCEPTANCE AND COMMITMENT THERAPY

    X. MOTIVATIONAL INTERVIEWING

    XI. CONCLUSIONS AND FUTURE DIRECTIONS

    27 Physical Therapy

    I. PHYSICAL THERAPY EVALUATION

    II. PHYSICAL THERAPY INTERVENTION/PAIN MANAGEMENT

    C. Education and Self-management

    D. Therapeutic Exercise

    E. Passive Modalities

    F. Coordination With Care Team

    III. CONCLUSION

    28 Myofascial Pain Syndrome and Fibromyalgia: Evaluation and Treatment

    I. OVERVIEW

    A. Myofascial Pain Syndrome

    B. Fibromyalgia

    II. EVALUATING THE PATIENT WITH CHRONIC WIDESPREAD PAIN

    A. Myofascial Pain Syndrome

    1. Clinical Presentation

    2. Diagnostic Criteria

    B. Fibromyalgia

    1. Clinical Presentation

    2. Diagnostic Criteria

    III. TREATMENT PRINCIPLES

    A. Myofascial Pain Syndrome

    1. Pharmacologic Management

    2. Interventional Treatments/Trigger Point Injections

    3. Rehabilitation Approaches

    4. Psychological Therapies

    B. Fibromyalgia

    1. Pharmacologic Management

    2. Interventional Treatments

    3. Rehabilitation Approaches

    4. Psychological Therapies

    IV. CONCLUSION

    29 Acupuncture

    I. INTRODUCTION

    II. THE THEORY OF ACUPUNCTURE TREATMENT

    III. COMPLICATIONS AND SIDE EFFECTS

    IV. SCIENTIFIC BASIS

    A. Central Nervous System

    B. Peripheral Nerve System

    C. Endogenous Opioid Peptides

    D. Neurotransmitters

    E. Nitric Oxide

    F. Functional Magnetic Resonance Imaging

    V. CLINICAL EVIDENCE

    A. Treatment Effect Categories From WHO

    B. Back Pain

    C. Neck and Shoulder Pain

    D. Headache

    E. Acupuncture for Other Pain

    F. Acupuncture for Other Medical Conditions

    VI. CHALLENGES OF ACUPUNCTURE TREATMENT

    VII. CONCLUSION

    SECTION VI: ACUTE PAIN

    30 Adult Postoperative Pain

    I. INTRODUCTION

    II. PRINCIPLES OF POSTOPERATIVE PAIN MANAGEMENT

    A. Preoperative Planning and Setting Expectations

    1. Physical Prehabilitation

    2. Psychological Prehabilitation

    III. METHODS OF POSTOPERATIVE ANALGESIA

    A. Pharmacology

    1. Opioids

    2. Nonsteroidal Anti-inflammatory Drugs

    3. Anticonvulsants

    4. Antidepressants

    5. N-Methyl-D-Aspartate (NMDA) Receptor Antagonists

    6. α2 Agonists

    7. Local Anesthetics

    B. Regional Anesthesia

    1. Epidural Analgesia

    2. Postoperative Pain Indications

    3. Management Principles

    4. Drug Choices

    5. Management of Inadequate Analgesia

    6. Patient-Controlled Epidural Analgesia

    7. Side Effects

    8. Complications

    9. Anticoagulation and Epidurals

    10. Single-Shot Neuraxial Morphine

    11. Peripheral Nerve Blockade

    12. Intraoperative Neural Blockade

    C. Nonpharmacologic Treatments

    1. Education

    2. Behavioral Therapy

    3. Physical Therapy

    IV. SPECIAL SUBPOPULATIONS

    A. The Elderly

    B. The Mentally and Physically Disabled

    C. Substance Use Disorder

    D. Intensive Care Patients

    E. Patients With Chronic Pain

    V. CONCLUSION

    31 Postoperative Pain in Children

    I. HISTORY

    II. PLANNING FOR POSTOPERATIVE ANALGESIA

    A. Multimodal Pain Therapy

    B. Communication

    III. ASSESSING ACUTE PAIN IN INFANTS AND CHILDREN

    A. Neonates, Infants, and Children Aged 4 Years and Younger

    B. Children Aged 4-8 Years

    C. Children Older Than 7 Years

    D. Children With Cognitive Impairment

    E. New Emerging Techniques to Assess for Pain

    IV. TREATMENT CHOICES

    A. Acetaminophen and Nonsteroidal Anti-inflammatory Drugs

    B. Opioids

    C. Emerging Coanalgesic Therapies

    D. Neuraxial and Regional Anesthesia and Analgesia

    E. Epidural Placement in Children

    F. Single-Shot Epidural and Caudal Analgesia

    G. Managing Epidural Infusions

    H. Treatment of Side Effects and Complications

    I. Spinals

    J. Peripheral Nerve Blocks

    K. Topical Analgesia

    L. Nonpharmacologic Techniques

    M. Cognitive Approaches

    N. Cutaneous Stimulation

    O. Acupuncture

    V. ANALGESIA FOR PEDIATRIC AMBULATORY SURGERY

    VI. ANALGESIA FOR NEONATES

    VII. CONCLUSION

    32 Care of Burn Patients

    I. EPIDEMIOLOGY

    II. ANATOMY AND PHYSIOLOGY

    A. Classification

    B. Mechanism of Burn Pain

    III. CLINICAL FEATURES

    A. Patterns of Burn Pain

    IV. MANAGEMENT

    A. Pharmacologic

    1. Opioids

    2. NSAIDs and Acetaminophen

    3. Anticonvulsants

    4. Antidepressants

    5. Alpha-2 Receptor Agonists

    V. ANESTHETICS

    A. Ketamine

    B. Propofol

    C. Regional Anesthesia

    VI. NONPHARMACOLOGIC

    33 Pain Management for Sickle Cell Disease

    I. INTRODUCTION

    II. OVERVIEW

    A. Epidemiology

    B. Pathophysiology

    C. Complications and Organ Systems Affected

    1. Hematologic

    2. Neurologic

    3. Cardiopulmonary

    4. Gastrointestinal and Renal

    5. Musculoskeletal

    III. ACUTE PAIN

    A. Vaso-occlusive Crisis (VOC)

    1. Overview

    2. Assessment of Pain

    B. Treatment

    C. Acute Chest Syndrome

    D. Preventive Therapy

    IV. CHRONIC PAIN

    A. Types of Chronic Pain in SCD

    B. Management

    C. Curative Therapy

    1. Stem Cell Transplant

    2. Gene Therapy

    V. PSYCHOSOCIAL CONSIDERATIONS

    34 Pain Management in the Trauma Patient

    I. INTRODUCTION

    II. MECHANISM OF PAIN IN TRAUMA

    A. Nociceptive Pain (Somatic or Visceral)

    B. Inflammatory Pain

    C. Neuropathic Pain

    III. CONSIDERATIONS

    A. Austere Settings

    B. Chronicity of Trauma Pain

    C. Surgery as Trauma

    IV. THERAPEUTIC OPTIONS

    A. Medications

    B. Regional Anesthesia

    V. SPECIAL POPULATIONS

    A. Chronic Pain Patient

    1. Opioid Dependence

    2. Methadone

    3. Buprenorphine

    VI. CONCLUSION

    SECTION VII: CHRONIC PAIN

    35 Neuropathic Pain Syndromes

    I. CLINICAL MANIFESTATIONS

    II. SPECIFIC NEUROPATHIC PAIN SYNDROMES

    A. Trigeminal Neuralgia

    B. Glossopharyngeal Neuralgia

    C. Occipital Neuralgia

    D. Brachial Plexus Syndromes

    E. Radiculopathy

    F. Postherpetic Neuralgia

    G. Meralgia Parethetica

    H. Postamputation Stump Pain and Phantom Limb Pain

    I. Complex Regional Pain Syndrome

    J. Painful Diabetic Neuropathy

    K. Diabetic Amyotrophy

    L. Small Fiber Neuropathy

    M. Erythromelalgia

    N. Central Post-stroke Pain

    O. Spinal Cord Injury

    P. Syringomyelia and Syringobulbia

    III. TREATMENT OF NEUROPATHIC PAIN

    IV. CONCLUSION

    36 Low Back Pain: Evaluation and Management

    I. LOW BACK PAIN OVERVIEW

    A. Location of Pain: Definitions

    B. Epidemiology

    C. Acute (<6 weeks) and Subacute (6-12 weeks) Low Back Pain

    D. Yellow Flags (Risk Factors for Development of Chronicity)

    E. Chronic Low Back Pain (>12 Weeks Duration)

    II. PATIENT ASSESSMENT

    A. History

    B. Physical Exam

    C. Diagnostic Testing

    III. ETIOLOGY OF LOWER BACK PAIN

    IV. TREATMENT FOR LOW BACK PAIN (TABLE 36.2)

    A. Multidisciplinary Approach to Treatment

    B. Pharmacologic Treatment

    1. Acetaminophen

    2. NSAIDs

    3. Skeletal Muscle Relaxants

    4. Tramadol and More Potent Opioids

    5. Tricyclic Antidepressants (TCAs)

    6. Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)

    7. Antiepileptics

    C. Psychological Treatments

    D. Physical and Rehabilitation Treatments

    1. Exercise Therapy

    2. Multidisciplinary Functional Rehabilitation Programs

    3. Other PT/Rehab Modalities Lacking RCT Support for Chronic LBP

    E. Complementary and Alternative Medicine Approaches

    1. Acupuncture

    2. Manual Medicine/Manipulation

    3. Sleep Support

    F. Interventional Minimally Invasive Percutaneous Approaches for Axial Low Back Pain

    1. General Principles

    2. Lumbar Facet (Zygapophyseal) Joint Interventions

    3. Sacroiliac Joint Interventions

    4. Lumbar Radicular Pain and Spinal Stenosis Treatment with Epidural Steroid Injections (ESI)

    5. Lumbar Postlaminectomy Syndrome and Spinal Cord Stimulation (SCS)

    37 Complex Regional Pain Syndrome

    I. HISTORY

    II. BASIC MECHANISMS

    III. CLINICAL PRESENTATION

    IV. DIAGNOSIS

    V. TREATMENT

    A. Physical Therapy

    B. Pharmacologic Treatments

    1. Neuropathic Pain Medications

    2. Nonsteroidal Anti-inflammatory Drugs

    3. Opioids

    4. Inhibitors of Osteoclast Activity

    5. Corticosteroids

    6. Others

    C. Regional Anesthesia

    1. Sympathetic Blockade

    2. Intravenous Regional Blockade

    3. Epidural Blockade

    4. Brachial Plexus Blockade

    D. Neuromodulation

    1. Spinal Cord Stimulation

    2. Peripheral Nerve Stimulation

    E. Psychotherapy

    VI. CONCLUSION

    38 Headache

    I. EPIDEMIOLOGY

    II. HEADACHE HISTORY

    A. Red Flags for Secondary Causes of Headache

    B. Distinguishing Primary Headache Disorders

    III. HEADACHE PHYSICAL EXAMINATION

    IV. HEADACHE LABORATORY TESTING AND IMAGING

    V. DIFFERENTIAL DIAGNOSIS

    A. Secondary Headache Disorders

    B. Primary Headache Disorders

    C. Selected Headache Disorders In-Depth

    VI. Treatments

    A. Lifestyle Treatments

    B. Preventive Migraine Treatments

    C. Interventional Treatments

    D. Acute Migraine Treatments

    E. Rescue Migraine Treatments

    F. Treatment of Trigeminal Autonomic Cephalgias and Selected Other Primary Headache Disorders

    VII. CONCLUSIONS AND KEY POINTS

    A. SNOOP Mnemonic

    B. Migrainous and Autonomic Features

    C. Patient Education

    D. Preventative Medications

    E. Rescue Treatment Plans

    39 Orofacial Pain

    I. DIAGNOSTIC EVALUATION

    A. Chief Complaint

    B. History of Present Complaint

    C. Medical History

    D. Physical Examination

    E. Intraoral Examination

    II. PAIN CAUSED BY PATHOLOGY OF THE HEAD, FACE, AND ORAL CAVITY

    A. Dental Pain (Table 39.1)

    B. Disorders of the Periodontium (Periodontal Disease)

    C. Oral Mucous Membrane Disorders (Table 39.2)

    D. Salivary Gland Disorders (Table 39.3)

    E. Disorders of Maxilla and Mandible

    F. Sinus Disorders

    G. Disorders of Eye and Ear

    H. Vascular Disorders

    I. Tumors

    III. TEMPOROMANDIBULAR DISORDERS (TABLE 39.7)

    A. Masticatory Muscle Disorders (Table 39.8)

    B. Temporomandibular Joint Disorders (Table 39.9)

    IV. NEUROPATHIC PAIN DISORDERS (TABLES 39.10 AND 39.11)

    A. Trigeminal Neuralgia

    B. Painful Posttraumatic Trigeminal Neuropathy

    C. Postherpetic Neuralgia

    D. Burning Mouth Syndrome

    SECTION VIII: CANCER PAIN AND PALLIATIVE CARE

    40 Pain in Adults With Cancer

    I. THE INCIDENCE AND IMPACT OF CANCER PAIN

    II. ASSESSMENT OF CANCER PAIN: THE IMPORTANCE OF A DIAGNOSTIC APPROACH

    III. TREATMENT OF CANCER PAIN

    A. The WHO Stepladder and Modern Approach to Pain

    B. Nonopioids

    C. Acetaminophen/NSAIDs

    D. Corticosteroids

    E. Neuropathic Agents

    F. Bisphosphonates and RANK Ligand Inhibitors

    G. Cannabinoids

    IV. OPIOID MANAGEMENT

    A. Opioid Selection

    B. Routes of Administration

    C. Renal and Hepatic Dysfunction

    D. Opioid Dosing and Titration

    E. Opioid Rotation

    F. Methadone

    G. Adverse Effects

    H. Addiction and Cancer Pain

    V. NONPHARMACOLOGIC THERAPIES FOR CANCER PAIN

    A. Radiation and Radionuclide Therapies

    B. Interventional Procedures: Vertebral Augmentation, Neurolytic Blockade, Cryoablation, and Cordotomy

    C. Neuraxial Drug Delivery: Epidural and Intrathecal Analgesia

    VI. REFRACTORY CANCER PAIN

    VII. CONCLUSION

    41 Pediatric Cancer Pain

    I. OVERVIEW OF PEDIATRIC CANCER

    A. Epidemiology

    B. Illness Trajectory

    II. PEDIATRIC CANCER PAIN PRESENTATION

    A. General

    B. Myths About Pediatric Pain

    C. Developmental Issues in the Expression of Pain

    III. ASSESSMENT OF PEDIATRIC CANCER PAIN

    A. Types of Pain

    B. Instruments to Report Pain

    IV. DISEASE AND TREATMENT-RELATED PAIN

    A. Disease-Related Pain

    B. Treatment-Related Pain

    V. TREATMENT OF CANCER-RELATED PAIN IN CHILDREN

    A. General Strategy

    B. Nonpharmacologic

    C. Nonopioids, Opioids, and Adjuvants

    D. Regional Anesthesia and Analgesia

    VI. CONCLUSION

    42 Palliative Medicine

    I. PALLIATIVE CARE OVERVIEW

    A. Palliative Care Vs Hospice

    II. CORE ELEMENTS OF PALLIATIVE CARE

    A. Symptom Control

    B. Patient-Centered Decision-Making

    C. Common Misconceptions

    D. Psychosocial and Spiritual Care

    III. MODES OF PALLIATIVE CARE DELIVERY

    IV. PAIN MANAGEMENT AT THE END OF LIFE

    A. Overview

    B. Patient Case: Pain Management at the End of Life

    V. NONPAIN SYMPTOM MANAGEMENT

    A. Overview

    B. Depression and Anxiety

    C. Constipation

    D. Delirium

    E. Dyspnea

    F. Nausea and Vomiting

    VI. SERIOUS ILLNESS COMMUNICATION WITH PATIENTS AND FAMILIES

    VII. PALLIATIVE SEDATION FOR REFRACTORY SYMPTOMS AT END OF LIFE

    VIII. CONCLUSION

    SECTION IX: SPECIAL CONSIDERATIONS IN PAIN MEDICINE

    43 Opioids in Chronic Nonterminal Pain

    I. INTRODUCTION

    II. RATIONALE FOR CHOOSING OPIOID THERAPY

    III. AREAS OF CONCERN

    A. Loss of Efficacy

    B. Unacceptable Side Effects

    C. Hormonal Effects

    D. Immune Effects

    E. Problematic Opioid Use

    F. Opioid Use in Elderly Populations

    IV. STRUCTURED, GOAL-ORIENTED APPROACH TO LONG-TERM TREATMENT

    A. Decision Phase

    B. Titration Phase

    C. Stable Phase

    1. Monthly Refills

    2. Comprehensive Follow-Up

    3. Toxicology Screening and Identifying Aberrant Behaviors

    D. Dose Escalation

    E. Criteria for Success and Failure

    F. Discontinuation

    V. CONCLUSION

    44 Identifying and Mitigating the Risks of Long-Term Opioid Treatment

    I. WEIGHING BENEFITS AND RISKS

    A. Benefits

    B. Risks

    C. Individual Risk Assessment

    II. RISK MITIGATION DURING LOT

    A. Monitoring

    B. Overdose Prevention

    C. Managing a Difficult Course of Treatment

    D. Discontinuation of LOT

    III. CONCLUSION

    45 Geriatric Pain Management

    I. GERIATRIC OVERVIEW

    A. Demographics and Prevalence

    B. Pharmacokinetics and Pharmacodynamics Considerations

    C. Changes in Pain Processing and Perception With Aging

    D. Consequences of Untreated Pain in the Older Adult

    E. American Geriatric Society Position on Pain Management

    II. PAIN ASSESSMENT

    A. General Overview

    B. Addressing Misconceptions

    C. Functional Pain Assessment

    D. Pain Assessment in Dementia

    E. Pain Assessment in Delirium

    III. PAIN THERAPEUTICS

    A. General Overview

    B. Pharmacotherapy

    1. Nonopioids

    2. Opioids

    C. Nonpharmacologic Interventions

    IV. CONCLUSION

    46 Management of Noncancer and Chronic Pain in Children With Life-Threatening Illness

    I. PRESENTATION OF NONCANCER AND CHRONIC PAIN IN CHILDREN WITH LIFE-THREATENING ILLNESSES

    A. Epidemiology

    B. Typical Trajectories

    II. GENERAL PRINCIPLES

    A. Development and the Pain System

    B. Maturation of the Nervous System

    C. Developmental Aspects of Drug Metabolism

    D. Cognitive Development

    E. Relational Aspects of Pain Presentation

    III. ASSESSMENT OF PAIN

    A. General Principles

    B. Pain Behavior and Physiologic Variables

    C. Self-report

    D. Conditions Presenting as Pain That Warrant Specific Attention

    E. The Assessment of Pain in Nonverbal Infants and Children

    IV. PAIN MANAGEMENT

    A. Pain Presentations and Types of Pain

    B. Pharmacologic Treatment

    C. Regional Anesthesia and Analgesia

    D. Other Techniques

    V. CONCLUSION

    47 Emergencies in Pain Medicine

    I. INTRODUCTION

    II. PROCEDURE-RELATED EMERGENCIES

    A. Vasovagal Syncope

    1. Symptoms and Signs

    2. Treatment

    B. Systemic Local Anesthetic Toxicity

    1. Treatment (Primary Goal to Prevent Acidosis and Hypoxemia)

    C. Complications of Epidural and Intrathecal Procedures

    1. Epidural Hematoma

    2. Epidural Abscess

    3. High Spinal Anesthetics

    4. Accidental Overdose via Neuraxial Pump

    5. Treatment

    D. Hypotension

    1. Treatment

    E. Hypertension

    1. Treatment

    F. Pneumothorax

    1. Symptoms

    2. Treatment

    III. MEDICATION-RELATED EMERGENCIES

    A. Anaphylaxis

    1. Symptoms and Signs

    2. Treatment

    B. Opioid Overdose

    1. Symptoms and Signs

    2. Treatment

    C. Opioid Withdrawal

    1. Symptoms and Signs

    2. Treatment

    D. Steroid Overdose and Adrenal Insufficiency

    1. Symptoms and Signs

    2. Treatment

    IV. CONCLUSION

    Appendix I: Dermatomes and Nerve Distribution

    Appendix II: Prescription Guidelines

    I. CDC PRESCRIBING RECOMMENDATIONS AND ERRATA

    II. FSMB PRESCRIBING GUIDELINES

    Appendix III: Drug Enforcement Administration (DEA) Drug Schedules

    I. DEFINITION OF CONTROLLED SUBSTANCE SCHEDULES

    Appendix IV: Medications Commonly Used in Pain Practice

    Appendix V: Definitions and Abbreviations

     

  • 30000lei 260.00 lei

     

    Description:

    Updated and expanded edition of this well-known Physics textbook provides an excellent Undergraduate introduction to the field

    This new edition of Nuclear and Particle Physics continues the standards established by its predecessors, offering a comprehensive and highly readable overview of both the theoretical and experimental areas of these fields. The updated and expanded text covers a very wide range of topics in particle and nuclear physics, with an emphasis on the phenomenological approach to understanding experimental data. It is one of the few publications currently available that gives equal treatment to both fields, while remaining accessible to undergraduates.

    Early chapters cover basic concepts of nuclear and particle physics, before describing their respective phenomenologies and experimental methods. Later chapters interpret data through models and theories, such as the standard model of particle physics, and the liquid drop and shell models of nuclear physics, and also discuss many applications of both fields. The concluding two chapters deal with practical applications and outstanding issues, including extensions to the standard model, implications for particle astrophysics, improvements in medical imaging, and prospects for power production. There are a number of useful appendices. Other notable features include:

    New or expanded coverage of developments in relevant fields, such as the discovery of the Higgs boson, recent results in neutrino physics, research to test theories beyond the standard model (such as supersymmetry), and important technical advances, such as Penning traps used for high-precision measurements of nuclear masses.

    Practice problems at the end of chapters (excluding the last chapter) with solutions to selected problems provided in an appendix, as well as an extensive list of references for further reading.

    Companion website with solutions (odd-numbered problems for students, all problems for instructors), PowerPoint lecture slides, and other resources.

    As with previous editions, the balanced coverage and additional resources provided, makes Nuclear and Particle Physics an excellent foundation for advanced undergraduate courses, or a valuable general reference text for early graduate studies. 

     

    Table of contents:

     

    1 Basic concepts

    1.1 History

    1.2 Relativity and antiparticles

    1.3 Space-time symmetries and conservation laws

    1.4 Interactions and Feynman diagrams

    1.5 Particle exchange: forces and potentials

    1.6 Observable quantities: cross-sections and decay rates

    1.7 Units

    Problems 1

    Notes

    2 Nuclear phenomenology

    2.1 Mass spectroscopy

    2.2 Nuclear shapes and sizes

    2.3 Semi-empirical mass formula: the liquid drop model

    2.4 Nuclear instability

    2.5 Decay chains

    2.6 β decay phenomenology

    2.7 Fission

    2.8 γ decays

    2.9 Nuclear reactions

    Problems 2

    Notes

    3 Particle phenomenology

    3.1 Leptons

    3.2 Quarks

    3.3 Hadrons

    Problems 3

    Notes

    4 Experimental methods

    4.1 Overview

    4.2 Accelerators and beams

    4.3 Particle interactions with matter

    4.4 Particle detectors

    4.5 Detector Systems

    Problems 4

    Notes

    5 Quark dynamics: the strong interaction

    5.1 Colour

    5.2 Quantum chromodynamics (QCD)

    5.3 New forms of matter

    5.4 Jets and gluons

    5.5 Deep inelastic scattering and nucleon structure

    5.6 Other processes

    5.7 Current and constituent quarks

    Problems 5

    Notes

    6 Weak interactions and electroweak unification

    6.1 Charged and neutral currents

    6.2 Charged current reactions

    6.3 The third generation

    6.4 Neutral currents and the unified theory

    6.5 Gauge invariance and the Higgs boson

    Problems 6

    Notes

    7 Symmetry breaking in the weak interaction

    7.1 P violation, C violation, and CP conservation

    7.2 Spin structure of the weak interactions

    7.3 Neutral kaons: particle–antiparticle mixing and CP violation

    7.4 CP violation and flavour oscillations in B decays

    7.5 CP violation in the standard model

    Problems 7

    Notes

    8 Models and theories of nuclear physics

    8.1 The nucleon–nucleon potential

    8.2 Fermi gas model

    8.3 Shell model

    8.4 Nonspherical nuclei

    8.5 Summary of nuclear structure models

    8.6 α decay

    8.7 β decay

    8.8 γ decay

    Problems 8

    Notes

    9 Applications of nuclear and particle physics

    9.1 Fission

    9.2 Fusion

    9.3 Nuclear weapons

    9.4 Biomedical applications

    9.5 Further applications

    Problems 9

    Notes

    10 Some outstanding questions and future prospects

    10.1 Overview

    10.2 Hadrons and nuclei

    10.3 Unification schemes

    10.4 The nature of the neutrino

    10.5 Particle astrophysics

    Notes

    A Some results in quantum mechanics

    A.1 Barrier penetration

    A.2 Density of states

    A.3 Perturbation theory and the Second Golden Rule

    A.4 Isospin formalism

    Problems A

    Notes

    B Relativistic kinematics

    B.1 Lorentz transformations and four-vectors

    B.2 Frames of reference

    B.3 Invariants

    Problems B

    Notes

    C Rutherford scattering

    C.1 Classical physics

    C.2 Quantum mechanics

    Problems C

    Note

    D Gauge theories

    D.1 Gauge invariance and the standard model

    D.2 Particle masses and the Higgs field

    Problems D

    Notes

    E Short answers to selected problems

    Problems 1

    Problems 2

    Problems 3

    Problems 4

    Problems 5

    Problems 6

    Problems 7

    Problems 8

    Problems 9

    Problems A

    Problems B

    Problems C

    References

    Index

    End User License Agreement

     

  • 29100lei 270.00 lei

    This book comprehensively and thoroughly reviews the current literature regarding the impact of health disparities and socioeconomic factors on allergic diseases outcomes: such as food allergies and anaphylaxis. The morbidity associated with these conditions is significantly higher in under-privileged populations around the world, including groups who have experienced greater social or economic obstacles to health based on racial, socioeconomic, gender, geographic location. Health Disparities in Allergic Diseases presents evidence and reviews studies from both developed and developing countries that witness health disparities in allergic disease. Concise in format, Health Disparities in Allergic Diseases: An Evidence-Based Look at Causes, Conditions, and Outcomes is made up of 11 expertly written chapters and divided into two parts. It begins with an introductory on global health through an analysis of the theoretical framework of epidemiologic transition. Subsequent chapters then review the socioeconomic and racial variables in treating allergic diseases using a multifactorial approach. Part II discusses disparities in allergic conditions, including asthma health, rhinitis and rhinosinusitis, food allergy, and atopic dermatitis. The book concludes with an exploration of potential strategies to providing solutions for asthmatic impoverished populations. Health Disparities in Allergic Diseases is a practical resource that can be used by researchers and clinicians in the field of allergy who are interested in learning about health related disparities in the context of allergic conditions or who seek solutions for this important issue.

    ·  Part I. Introductory Chapters

    ·  1. Global Health: Reimagining Perspectives

    ·  2. Allergic Diseases in the Developing World: An Emerging Problem or an Overseen Issue?

    ·  3. Racial and Ethnic Disparity in Allergic Diseases in the United States: Example of a Large Country with a Diverse Population

    ·  4. Disparity in Access to Care and Its Impact on Diagnosis and Outcomes of Allergic Diseases

    ·  Part II. Disparity on Allergic Conditions by Disease

    ·  5. Disparity in Rhinitis and Rhinosinusitis

    ·  6. Disparities in Food Allergy

    ·  7. Asthma Health Disparities

    ·  8. Disparity in Atopic Dermatitis

    ·  Part III. Providing Solutions

    ·  9. School-Based Educational Programs to Improve the Knowledge and Outcome in Allergic Conditions

    ·  10. Providing Feasible Solutions for an Asthmatic Impoverished Population

    ·  11. Global and National Networks and Their Role in Fighting Disparity in Allergic Diseases


  • 30000lei 270.00 lei


     

    Written and edited by leading cancer experts at Memorial Sloan Kettering Cancer Center, Pocket Oncology, Second Edition, is a practical, high-yield reference for trainees and practitioners of medical oncology and hematology. This easy-to-use, loose-leaf resource contains up-to-date information essential to caring for patients with cancer, from cancer biology, prevention, screening, treatment and supportive care to new advances in immuno-oncology and precision medicine. Includes new information on chimeric antigen receptor (CAR) T cell therapy, immunotherapy toxicity, and novel oral anticoagulants, as well as more information on precision targeted therapeutic strategies. Presents each oncologic disease on two facing pages that review initial clinical presentation, pathophysiology, staging, current standards of care treatments, and active areas of current research. Follows the popular Pockets Notebook format, featuring bulleted lists, tables, diagrams, and algorithms that make essential facts easy to find and retain. Contains helpful appendices on radiographic response criteria, quality of life assessments, tumor markers, and more, plus a section of clinically essential color photos. Ideal as a pocket reference for daily practice as well as an accepted and trusted resource for trainees and other members of the oncology care team. Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! Read directly on your preferred device(s), such as computer, tablet, or smartphone Customize for your language, including right-to-left reading, vertical writing, and enhanced annotation in over 30 languages Easily convert to audiobook, powering your content with natural language text-to-speech Adapt for unique reading needs, supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more

  • 270.00 lei



    Concise, portable, and packed with essential information, Manual of Clinical Oncology is an indispensable resource for understanding basic science, clinical findings, and available technology as they relate to the diagnosis and management patients with cancer.  The practical format provides high-yield content useful for participating in rounds ad making diagnostic and therapeutic decisions at the bedside.  Edited by Dr. Bartosz Chmielowski  and Dr. Mary Territo, both from UCLA School of Medicine, this eighth edition carries on the tradition of excellence set forth by longtime editor Dr. Dennis Casciato.

    Key Features:

    • Incorporates recent major achievements in immunotherapies, biologics, and targeted therapies.
    • Features new chapters on the biology of cancer, immunotherapy, and cancer survivorship.
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  • 280.00 lei

    The new edition of this book is a complete guide to the diagnosis and management of head and neck cancers. Divided into seven sections, the text covers thyroid, salivary glands and parapharyngeal tumours, neck, paranasal sinuses, oral cavity and oropharynx, larynx, hypopharynx and nasopharynx, with a final section on general topics. Each topic includes discussion on pathology, imaging, and medical and surgical management. The second edition has been fully revised to provide the latest advances in the field, and includes new chapters on parathyroid tumours, infratemporal fossa, temporal bone tumours, facial nerve tumours, tracheostomy, and skin cancers. Recent changes in the American Joint Cancer Committee (AJCC) 8th Edition staging system have been incorporated. More than 300 photographs, illustrations and tables further enhance the comprehensive text. Key points Comprehensive guide to diagnosis and management of head and neck cancers Fully revised, second edition with many new topics included Covers recent changes in the American Joint Cancer Committee (AJCC) 8th Edition staging system Previous edition (9789351527916) published in 2015

  • 30000lei 280.00 lei

     

    Description:

    Provides a clear and accessible summary of all stages and aspects of the discovery, design, development, validation and clinical use of anticancer drugs

    This new edition provides an update on the current state of the art of cancer chemotherapy and clinical practice and presents new pipeline anticancer agents and promising therapeutic strategies that are emerging alongside new breakthroughs in cancer biology. Its unique approach enables students to gain an understanding of the pathological, physiological, and molecular processes governing malignancy, while also introducing the role of health professionals and scientists in the research and treatment of cancer.

    Invaluable for its clarity and accessibility, Cancer Chemotherapy: Basic Science to the Clinic, 2nd Edition offers complete coverage of the scientific and clinical aspects of the creation, development, and administration of drugs or drug regimens used in the treatment of the disease. Chapters look at: cancer epidemiology and histopathology; carcinogenesis; current research; tumor hypoxia; antiangiogenic and antivascular agents; protein kinase and Ras blockers; new targets associated with development such as Hedgehog and Wnt signaling; stem cells; immunotherapy and oncolytic viruses; and more.

    Presents a clear, accessible, and comprehensive approach to cancer chemotherapy from basic science to clinical practice

    Offers a major update that reflects the latest developments in personalized chemotherapy

    Provides in-depth coverage of advances in biomarker diagnostics

    Includes new chapters/sections on bioinformatics and the ‘omic sciences’; pharmaceutical strategies used to achieve tumor-selective drug delivery; and cancer cell autophagy

    Combines descriptions of both clinical protocol and explanations of the drug design process in one self-contained book

    Features numerous diagrams and illustrations to enhance reader understanding

    Aimed at upper undergraduate, graduate, and medical students, Cancer Chemotherapy: Basic Science to the Clinic, 2nd Edition is also an excellent reference for health professional, especially clinicians specializing in Clinical Oncology, and their patients who want to gain an understanding of cancer and available treatment options.

     

    Table of contents:

     

    1 Cancer Epidemiology

    1.1 Cancer Incidence and Mortality

    1.2 Childhood Cancer

    1.3 Global Epidemiology

    1.4 Cancer Survival Rates

    1.5 Summary and Conclusions

    Further Reading

    2 Cancer Histopathology

    2.1 Cancer Morphology, Phenotype, and Nomenclature

    2.2 Apoptosis

    2.3 Necrosis

    2.4 Autophagy and Others

    2.5 Summary and Conclusions

    Further Reading

    3 Carcinogenesis

    3.1 Initiation

    3.2 Promotion

    3.3 Progression and Environmental Carcinogenesis

    3.4 Cell Cycle

    3.5 Summary and Conclusions

    Further Reading

    4 Molecular Biology of Cancer

    4.1 Oncogenes: Disruptors and Instigators

    4.2 Cellular Oncogenes

    4.3 Viral Oncogenes

    4.4 Altered Oncogenic Products

    4.5 Biological Carcinogens

    4.6 Tumor Suppressor Genes

    4.7 Familial Cancers and Cancer Syndromes

    4.8 Summary and Conclusions

    Further Reading

    5 Cancer Metastasis

    5.1 Detachment from the Primary Tumor

    5.2 Migration of Cancer Cells from Primary Tumor

    5.3 Intravasation of Tumor Cells into Vessels

    5.4 Metastatic Transport

    5.5 Extravasation

    5.6 Growth of the Metastatic Tumor Mass

    5.7 Summary and Conclusions

    Further Reading

    6 Health Professionals and Cancer Treatment

    6.1 Pathology

    6.2 Radiology

    6.3 Biopsies

    6.4 Surgical Treatment

    6.5 Oncology Pharmacy

    6.6 Oncology Nursing

    6.7 Artificial Intelligence and Healthcare

    6.8 Summary and Conclusions

    Further Reading

    7 Principles of Cancer Chemotherapy

    7.1 Staging, Treatment, and Monitoring

    7.2 General Types of Chemotherapy

    7.3 Biomarker Uses and Limitations

    7.4 Pharmacogenetics, Pharmacogenomics, Pharmacokinetics, Pharmacodynamics, and Personalized Medicine

    7.5 Summary and Conclusions

    Further Reading

    8 Cytotoxic Compounds

    8.1 Alkylating Agents

    8.2 Intercalating Agents

    8.3 Topoisomerase Blockers

    8.4 Tubulin Disruptors

    8.5 Summary and Conclusions

    Further Reading

    9 Antimetabolites and Hormonal Blockers

    9.1 Nucleic Acid Analogs

    9.2 Folate Analogs

    9.3 Amino Acid Blockers

    9.4 Hormone Modulators

    9.5 Estrogen Antagonists

    9.6 Aromatase Inhibitors

    9.7 Antiandrogens

    9.8 Endocrine Therapy

    9.9 Summary and Conclusions

    Further Reading

    10 Cancer Research

    10.1 Gel Electrophoresis Methods

    10.2 Polymerase Chain Reaction

    10.3 Molecular Cloning

    10.4 EnzymeLinked Immunosorbent Assay, Immunohistochemistry, and Immunofluorescence

    10.5 Mass Spectroscopy and Proteomics

    10.6 Genomics, Transcriptomics, and Metabolomics

    10.7 Microarrays

    10.8 Cell Culture and Exogenous Expression Strategies

    10.9 Protein Expression and Targeting

    10.10 Animal Models

    10.11 Delivery Systems

    10.12 Resources

    10.13 Summary and Conclusions

    Further Reading

    11 Clinical Trials

    11.1 Clinical Trial Design

    11.2 Clinical Trials Governance and Quality Assurance

    11.3 Clinical Trial Ethics

    11.4 Clinical Trial Study Schema

    11.5 Measurement of Clinical Endpoints, Response, and Outcomes

    11.6 Local and National Organization of Clinical Trials

    11.7 Summary and Conclusions

    Further Reading

    12 Tumor Hypoxia

    12.1 Effects of Hypoxia on Chemotherapy

    12.2 Energy Reprogramming and the Warburg Effect

    12.3 HypoxiaInducible Factor

    12.4 Lactate Dehydrogenase and Carbonic Anhydrase

    12.5 Hypoxic Vascularization and Imaging

    12.6 Bioreductive Drugs

    12.7 Summary and Conclusions

    Further Reading

    13 Antiangiogenic and Antivascular Agents

    13.1 History of Antiangiogenic Chemotherapy

    13.2 Endogenous Integrin Blockers

    13.3 Matrix Metalloproteinase Inhibitors

    13.4 Synthetic Integrin Blockers

    13.5 The Return of Thalidomide

    13.6 Vascular Disrupting Agents

    13.7 Antiangiogenic Antibodies

    13.8 Summary and Conclusions

    Further Reading

    Note

    14 Protein Kinase and Ras Blockers

    14.1 Signal Transduction

    14.2 Receptor Tyrosine Kinase Blockers

    14.3 Nonreceptor Tyrosine Kinase Blockers

    14.4 Receptor Serine/Threonine Kinase Blockers

    14.5 Nonreceptor Serine/Threonine and Multiple Kinase Blockers

    14.6 Ras and PLC Blockers

    14.7 Summary and Conclusions

    Further Reading

    15 Modulating Global Gene and Protein Expression

    15.1 Stress Protein Inhibitors

    15.2 Proteasome Inhibitors

    15.3 Ubiquitin Ligase Inhibitors

    15.4 Histone Deacetylase Inhibitors

    15.5 DNA Methylation Inhibitors

    15.6 Summary and Conclusions

    Further Reading

    16 Stem Cells – Telomerase, Wnt, Hedgehog, Notch, and Galectins

    16.1 Telomerase Blockers

    16.2 Wnt Blockers

    16.3 Hedgehog Blockers

    16.4 Notch Blockers

    16.5 Galectin Blockers

    16.6 Summary and Conclusions

    Further Reading

    17 Immunotherapy and Oncolytic Viruses

    17.1 Immunization

    17.2 Immune Checkpoint Blockers

    17.3 Chimeric Antigen Receptor TCells

    17.4 Oncolytic Viruses

    17.5 Summary and Conclusions

    Further Reading

    18 Pharmaceutical Problems in Cancer Chemotherapy

    18.1 Manifestation of Toxicity

    18.2 RegimenRelated Toxicity

    18.3 Secondary Malignancies

    18.4 Drug Resistance

    18.5 Pharmaceutical Complications

    18.6 Phlebitis and Venous Irritation

    18.7 Health and Safety

    18.8 National Guidance on the Safe Administration of Intrathecal Chemotherapy

    Further Reading

    Index

    End User License Agreement

     

  • 34100lei 290.00 lei

     

    Description:

    Sized to fit in your pocket for quick reference, Handbook for Principles and Practice of Gynecologic Oncology, 3rd Edition, is packed with the essential information you need on the diagnosis and management of gynecologic cancers. Now in full color for the first time, this bestselling handbook features coverage of the most recent developments in the field, clear and concise data that support treatment recommendations, and numerous algorithms and tables throughout. Fellows, residents, and specialist trainees will benefit from authoritative coverage in an easily accessible format.

     

    Table of Contents:

     

    1 Principles of Systemic Therapy in Gynecologic Cancer

    2 Biologic and Physical Aspects of Radiation Oncology

    3 Clinical Genetics of Gynecologic Cancer

    4 Preinvasive Lesions of the Genital Tract

    5 The Vulva

    6 The Vagina

    7 The Uterine Cervix

    8 The Corpus: Epithelial Tumors

    9 The Corpus: Mesenchymal Tumors

    10 Ovarian Cancer (Including the Fallopian Tube)

    11 Nonepithelial Ovarian Cancer

    12 Molar Pregnancy and Gestational Trophoblastic Neoplasms

     

  • 32000lei 290.00 lei

     

    Description:

    Now in its third edition, Practical Radiotherapy continues to keep pace with current and emerging technologies, patient pathways, and the rapidly expanding role of therapeutic radiographers.

    Extensively revised and updated, this accessible book examines all the essential aspects of radiotherapy, from the physics and mathematics of radiation beams, to in-depth descriptions of the equipment used by radiotherapy practitioners, to new and expanded coverage of MR-linac and Halcyon technology, proton therapy, stereotactic body radiotherapy, sealed-source verification and quality assurance for MV equipment.

    Covers all the core information essential to radiotherapy practice

    Describes the major aspects of therapeutic radiography in a practical context

    Includes updated self-assessment tests, images and diagrams, supplemental reading suggestions and more radiotherapy-specific examples

    Features expanded coverage of legislation, advanced treatment delivery, flattening filter free treatment and more

    Practical Radiotherapy is a valuable resource for radiotherapy and medical physics students, radiotherapists, therapeutic radiographers, radiation therapists, clinical oncologists and oncology nurses.

     

    Table of contents:

     

    Acknowledgement of Previous Contributors

    CHAPTER 1: Introduction to Radiotherapy Practice

    1.1 Introduction

    1.2 What Is Radiotherapy?

    1.3 Working with Ionising Radiations

    1.4 How Radiotherapy Works

    1.5 Radiotherapy Beam Production

    1.6 Treatment Delivery and Planning

    1.7 Treatment Accuracy and Patient Immobilisation

    1.8 Technology and Techniques

    1.9 Current Radiotherapy Practice

    References

    Further Reading

    CHAPTER 2: Mathematical Skills Relevant for Radiotherapy Physics, Atomic Structure, and Radioactivity

    2.1 Mathematical Skills Relevant for Radiotherapy Physics

    2.2 Basic Physics Relevant to Radiotherapy

    2.3 Heat and Temperature

    2.4 Electricity, Magnetism, and Electromagnetic Radiation

    2.5 The Electromagnetic Spectrum

    2.6.4 Electron Orbits

    2.6.5 Atomic Energy Levels

    2.7 Classification of Nuclides

    2.9 Background Radiation

    Further Reading

    CHAPTER 3: Xray Production

    3.1 Introduction

    3.2 The Xray Tube

    3.3 Xray Production

    3.4 Xray Output Intensity

    3.5 Beam Quality

    3.6 Factors Affecting the Output Intensity and Quality of the Beam

    3.7 Xray Production and Clinical Practice

    Further Reading

    CHAPTER 4: Radiation Detection and Measurement

    4.1 The Unit of Absorbed Dose

    4.2 FreeAir Ionisation Chamber

    4.3 Cavity Chamber (Cylindrical or Thimble Chamber)

    4.4 Parallel Plate (Pancake) Chambers

    4.5 Air Kerma

    4.6 Dosimetry of Megavoltage Photons

    4.7 Radiation Detection and Measurement

    4.8 Thermoluminescent Dosimeters

    4.9 TLD Detector Types

    4.10 Optically Stimulated Luminescence (OSL) Dosimetry

    4.11 Dosimetry in CT

    4.12 MRI LinAc

    References

    Further Reading

    CHAPTER 5: Xray Interactions with Matter

    5.1 Introduction

    5.2 Xray Interaction Processes

    5.3 Electron Interactions and Ranges

    Further Reading

    CHAPTER 6: Principles of Imaging Modalities

    6.1 Introduction

    6.2 2D Imaging

    6.3 Plain Radiography Image Generation

    6.4 CT

    6.5 MRI

    6.6 Ultrasound

    6.7 PET

    6.8 Image Registration, Image Fusion, and Multimodality Imaging

    6.9 Hybrid and Functional Imaging

    6.10 Future Perspectives of Pretreatment Imaging

    References

    Further Reading

    CHAPTER 7: Principles of Treatment Accuracy and Reproducibility

    7.1 Introduction

    7.2 Scanner Aperture Size

    7.3 Reference Points and Anatomical Landmarks

    7.4 Treatment Tattoos Versus Semipermanent Skin Marks

    7.5 Lasers and Treatment Setup

    7.6 Volume Definitions and Target Defining Concepts

    7.7 Treatment Bolus and 3D Bolus Printing

    7.8 Immobilisation Shells

    7.9 Immobilisation Equipment for Head and Neck Treatment

    7.10 Immobilisation Techniques and Proton Beam Radiotherapy

    7.11 Immobilisation Equipment for Breast Treatment

    7.12 Respiratory Movements

    7.13 Thorax Immobilisation

    7.14 Immobilisation Equipment for Pelvic Treatment

    7.15 Superficial Radiotherapy

    7.16 Position Reproducibility in Emergency or Palliative Radiotherapy

    7.17 Immobilisation for Less Common Techniques

    7.18 Immobilisation Equipment for Treatment of Extremities

    7.19 Immobilisation of the Paediatric Radiotherapy Patient

    7.20 Stereotactic Radiotherapy

    7.21 Conclusion

    Acknowledgements

    References

    Further Reading

    CHAPTER 8: Radiotherapy Beam Production

    8.1 Introduction

    8.2 Kilovoltage Equipment

    8.3 Superficial and Orthovoltage Equipment

    8.4 Inverse Square Law

    8.5 Quality Assurance Tests

    8.6 Linear Accelerators

    8.7 Production and Transport of the RF Wave

    8.8 Ancillary Equipment

    8.9 Treatment Head

    8.10 Patient Support System

    8.11 Imaging Systems

    8.12 Other Linear Accelerator Designs

    8.13 Quality Assurance of a Linear Accelerator

    8.14 Cyclotrons and Proton Beams

    8.15 Gamma Knife

    8.16 Intraoperative Radiotherapy

    8.17 Treatment Delivery Techniques

    Acknowledgements

    References

    CHAPTER 9: Principles and Practice of Treatment Planning

    9.1 Introduction

    9.2 Treatment Planning Principles

    9.3 ICRU Guidelines

    9.4 Treatment Planning Objectives

    9.5 Treatment Planning Process

    9.6 Advanced Treatment Planning

    9.7 Quality Assurance

    References

    CHAPTER 10: Imageguided Radiotherapy and Treatment Verification

    10.1 Introduction

    10.2 Fundamental Principles of Treatment Verification

    10.3 Sitespecific Uncertainties and Protocols

    10.4 Record and Verify Systems and ComputerControlled Delivery

    10.5 Conclusion

    References

    CHAPTER 11: Quality Management in Radiotherapy

    11.1 Introduction

    11.2 What Is Quality?

    11.3 Quality Assurance and Quality Control

    11.4 Quality Management

    11.5 QMS

    11.6 ISO 9000

    11.7 The Radiotherapy QMS

    11.8 Document Control

    11.9 Concessions and Nonconformances

    11.10 Clinical Governance

    11.11 Risk Management

    11.12 Risk Assessment

    11.13 Reducing Risk

    11.14 Clinical Incidents: Reporting and Learning

    11.15 Why Is it Important to Report?

    11.16 Clinical Audit

    References

    CHAPTER 12: Radiation Protection

    12.1 Dangers of Ionising Radiations

    12.2 Rationale for Radiation Protection

    12.3 Radiation Protection in Practice

    12.4 Radiation Protection by Design

    12.5 Personal Monitoring

    12.6 Radiation Protection Legislation

    12.7 Radiation Protection Organisations

    12.8 IR(ME)R 2018

    12.9 IRR 2017

    References

    CHAPTER 13: The Use of Radionuclides in Molecular Imaging and Molecular Radiotherapy

    13.1 Introduction

    13.2 Radionuclides

    13.3 Imaging Equipment

    13.4 Single Photon Emission Computed Tomography (SPECT)

    13.5 Positron Emission Tomography (PET)

    13.6 Hybrid Imaging Systems

    13.7 Radiopharmaceuticals

    13.8 Tumour (Molecular) Imaging and Molecular Radiotherapy (MRT)

    13.9 Radiation Protection Related to Radioactive Substances

    13.10 Dosimetry

    References

    CHAPTER 14: Brachytherapy Physics and Equipment

    14.1 Introduction

    14.2 The Journey from Live Loading to Remote Afterloading

    14.3 Brachytherapy Terminology

    14.4 The Impact of Dose Rate

    14.5 Afterloading Equipment

    14.6 HDR Afterloaders

    14.7 Brachytherapy Dosimetry

    14.8 Transfer of Information to the Treatment Unit and Checking of Data

    14.9 Principles of Safe Treatment Delivery

    14.10 Treatment Protocols in Brachytherapy

    14.11 Clinical Examples

    14.12 Conclusion

    References

    Index

    End User License Agreement

     

  • 300.00 lei

    Se tipărește la comandă în aproximativ 4-8 săptămâni.

    The single most important fact about breast cancer is the great variation in its natural history and its responsiveness to therapy from one patient to another. The clinician must integrate an assessment of the patient's likely course based on clinical and pathological staging and laboratory studies with objective evidence on the benefits of therapy. The primary aim of this book is to provide the clinician with the tools to do just that. Outcomes of clinical trials and details about commonly used drug regimens, drug dosage, and the expected side effects are summarized in generous tables and figures. Medical terminology has been defined and descriptions of the evolution in our thinking and understanding of the disease are often given to provide perspective in the interpretation of evidence from current studies for busy clinicians and trainees alike.

  • 305.00 lei

     

    Description:

    Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Perfect for any clinician short on time who needs to practice for oncology board exams, The Bethesda Review of Clinical Oncology is from the same authors who brought you the trusted and bestselling Bethesda Handbook of Clinical Oncology. It’s packed with hundreds of disease-specific questions that are formatted just like an actual board review exam—so you can prep as effectively as possible and achieve test success.

     

     

    Table of Contents:

     

    Chapter 1 Head and Neck

    Chapter 2 Non–Small Cell Lung Cancer

    Chapter 3 Small Cell Lung Cancer

    Chapter 4 Esophageal Cancer

    Chapter 5 Gastric Cancers

    Chapter 6 Biliary Tract Cancer

    Chapter 7 Primary Cancers of the Liver

    Chapter 8 Gastrointestinal Stromal Tumors (GIST)

    Chapter 9 Colorectal Cancer

    Chapter 10 Pancreatic Cancer

    Chapter 11 Anal Cancer

    Chapter 12 Breast Cancer

    Chapter 13 Renal Cell Cancer

    Chapter 14 Prostate Cancer

    Chapter 15 Bladder Cancer

    Chapter 16 Testicular Carcinoma

    Chapter 17 Ovarian Cancer

    Chapter 18 Endometrial Cancer

    Chapter 19 Cervical Cancer

    Chapter 20 Vulvar Cancer

    Chapter 21 Sarcomas and Malignancies of the Bone

    Chapter 22 Skin Cancers and Melanoma

    Chapter 23 Acute Leukemia

    Chapter 24 Chronic Lymphoid Leukemias

    Chapter 25 Chronic Myeloid Leukemias

    Chapter 26 Chronic Myeloproliferative Neoplasms

    Chapter 27 Multiple Myeloma

    Chapter 28 Non-Hodgkin’s Lymphoma

    Chapter 29 Hodgkin Lymphoma

    Chapter 30 Hematopoietic Cell Transplantation

    Chapter 31 Carcinoma of Unknown Primary

    Chapter 32 Central Nervous System Tumors

    Chapter 33 Endocrine Tumors

    Chapter 34 Hematopoietic Growth Factors

    Chapter 35 Infectious Complications in Oncology

    Chapter 36 Oncologic Emergencies and Paraneoplastic Syndromes

    Chapter 37 Psychopharmacologic Management in Oncology

    Chapter 38 Management of Emesis

    Chapter 39 Nutrition

    Chapter 40 Pain and Palliative Care

    Chapter 41 Central Venous Access Device

    Chapter 42 Procedures in Medical Oncology

    Chapter 43 Basic Principles of Radiation Oncology

    Chapter 44 Clinical Genetics

    Chapter 45 Basic Principles of Immuno-Oncology

    Chapter 46 Anticancer Agents

     

  • Cancer-Causing Viruses and Their Inhibitors
    La comanda in aproximativ 4 saptamani
    310.00 lei

     

    Description:

    Cancer-causing viruses, also called oncoviruses, play a key role in the development of certain cancers. They contribute to genetic changes that disrupt the cell cycle machinery, interfering with functions such as cell growth. Cancer-Causing Viruses and Their Inhibitors presents a plethora of research from internationally reputed contributors who discuss different types of oncoviruses, their mechanisms of invasion and growth, and their life cycles. The book begins with an overview of the oncoviruses discovered to date and includes a brief description of their structures, genotypes, replication, and mechanisms of infection leading to cancers. It then explores several of these viruses in detail, including: Human T-cell leukemia virus type 1 (HTLV-1) Hepatitis C virus (HCV) Epstein–Barr virus (EBV) Human papilloma virus (HPV) Human herpes virus 8 (HHV-8)/Kaposi’s sarcoma-associated herpes virus (KSHV) Human immunodeficiency virus (HIV/AIDS) Oncolytic viruses This book is an essential reference for those working in virology, oncology, and biotechnology. The discoveries presented will enable researchers and clinicians to optimize both historical and current approaches to anti-viral therapies.

     

     

    Table of contents:

     

    Chapter 1: Cancer-Causing Viruses : An Introduction

    Chapter 2: Targeting Human T-Cell Leukemia Virus Type 1 : Pathogenesis and Treatment Strategies

    Chapter 3: Hepatitis C Virus and Its Inhibitors : The Polymerase as a Target for Nucleoside and Nucl

    Chapter 4: Mechanisms of Hepatitis C Virus Clearance by Interferon and Ribavirin Combination : Lesso

    Chapter 5: Hepatitis B Virus Infection and Hepatocellular Carcinoma

    Chapter 6: Epstein–Barr Virus and Treatment of Its Infection

    Chapter 7: Landscape of Papillomavirus in Human Cancers : Prevention and Therapeutic Avenues

    Chapter 8: Role of High-Risk Human Papillomaviruses in Breast Carcinogenesis

    Chapter 9: Prospective Therapies of Genital Human Papillomavirus Infections

    Chapter 10: Human Herpesvirus Type 8/Kaposi Sarcoma Herpesvirus : An Overview of Viral Pathogenesis

    Chapter 11: Tea Polyphenolic Compounds against Herpes Simplex Viruses

    Chapter 12: HIV Integrase Inhibitors : Qualitative and Quantitative Structure–Activity Relationshi

    Chapter 13: Virus Wars : Oncolytic versus Oncogenic Viruses

    Chapter 14: Oncolytic Viruses and Histone Deacetylase Inhibitors

     

  • 310.00 lei

     

    Description:

    Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. The sixth edition of the MD Anderson Surgical Oncology Handbook focuses on multidisciplinary, cooperative approaches to issues confronting the surgical oncologist. Organized by disease and in full color for the first time, this volume is comprehensive yet concise, and takes into account all of the oncologic issues you need to consider in order to fully understand each disease and its relevant treatments.

     

    Table of Contents:

     

    1 Noninvasive Breast Cancer

    2 Invasive Breast Cancer

    3 Melanoma

    4 Nonmelanoma Skin Cancer

    5 Soft-Tissue and Bone Sarcoma

    6 Cancer of the Head and Neck

    7 Thoracic Malignancies

    8 Esophageal Carcinoma

    9 Primary Gastric Malignancies

    10 Small Bowel Malignancies

    11 Peritoneal Malignancies

    12 Cancer of the Colon, Rectum, and Anus

    13 Hepatobiliary Cancers

    14 Pancreatic Ductal Adenocarcinoma

    15 Pancreatic Neuroendocrine Tumors and Multiple Endocrine Neoplasia

    16 Adrenal Tumors

    17 Carcinoma of the Thyroid Gland and Neoplasms of the Parathyroid Glands

    18 Hematologic Malignancies and Splenic Tumors

    19 Genitourinary Cancer

    20 Gynecologic Cancers

    21 Neurosurgical Malignancies: Treating Tumors of Brain and Spine and Their Effects on the Nervous System

    22 Cancer of Unknown Primary Site

    23 Surgical Emergencies in Cancer Patients

    24 Principles of Radiation Oncology

    25 Reconstructive Surgery in Cancer Patients

    Index

     

  • The Bethesda Handbook of Clinical Oncology
    La comanda in aproximativ 4 saptamani
    36000lei 310.00 lei

     


    The Bethesda Handbook of Clinical Oncology is a comprehensive review of the management of numerous cancer types, emphasizing practical information that can be applied in everyday, fast-moving patient care situations. With contributions from experts and scholars at the National Cancer Institute, National Institutes of Health, Cleveland Clinic, and other renowned institutions, this latest edition has been thoroughly revised with new content and continues to provide practical guidance on how to evaluate, diagnose, and treat cancer patients. Designed for quick and easy accessibility of clinically relevant information. Features a new comprehensive chapter on the principles and practice of immunotherapy. Disease-specific chapters now include information on relevant and appropriate immunotherapeutic drugs. Covers a range of solid-tumor, blood, and other cancers, as well as infection management, nutrition, and palliative care. Combines concise and clear information with tables, images, and algorithms; now with even more algorithms to help fine-tune clinical decision-making. Useful for oncologists, oncology nurses, oncology fellows, residents, and allied health professionals. Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! Read directly on your preferred device(s), such as computer, tablet, or smartphone Customize for your language, including right-to-left reading, vertical writing, and enhanced annotation in over 30 languages Easily convert to audiobook, powering your content with natural language text-to-speech Adapt for unique reading needs, supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more.

     

     

    ·  Chapter 1 Head and Neck

    ·  Chapter 2 Non–Small Cell Lung Cancer

    ·  Chapter 3 Small Cell Lung Cancer

    ·  Chapter 4 Esophageal Cancer

    ·  Chapter 5 Gastric Cancers

    ·  Chapter 6 Biliary Tract Cancer

    ·  Chapter 7 Primary Cancers of the Liver

    ·  Chapter 8 Gastrointestinal Stromal Tumors (GIST)

    ·  Chapter 9 Colorectal Cancer

    ·  Chapter 10 Pancreatic Cancer

    ·  Chapter 11 Anal Cancer

    ·  Chapter 12 Breast Cancer

    ·  Chapter 13 Renal Cell Cancer

    ·  Chapter 14 Prostate Cancer

    ·  Chapter 15 Bladder Cancer

    ·  Chapter 16 Testicular Carcinoma

    ·  Chapter 17 Ovarian Cancer

    ·  Chapter 18 Endometrial Cancer

    ·  Chapter 19 Cervical Cancer

    ·  Chapter 20 Vulvar Cancer

    ·  Chapter 21 Sarcomas and Malignancies of the Bone

    ·  Chapter 22 Skin Cancers and Melanoma

    ·  Chapter 23 Acute Leukemia

    ·  Chapter 24 Chronic Lymphoid Leukemias

    ·  Chapter 25 Chronic Myeloid Leukemias

    ·  Chapter 26 Chronic Myeloproliferative Neoplasms

    ·  Chapter 27 Multiple Myeloma

    ·  Chapter 28 Non-Hodgkin’s Lymphoma

    ·  Chapter 29 Hodgkin Lymphoma

    ·  Chapter 30 Hematopoietic Cell Transplantation

    ·  Chapter 31 Carcinoma of Unknown Primary

    ·  Chapter 32 Central Nervous System Tumors

    ·  Chapter 33 Endocrine Tumors

    ·  Chapter 34 Hematopoietic Growth Factors

    ·  Chapter 35 Infectious Complications in Oncology

    ·  Chapter 36 Oncologic Emergencies and Paraneoplastic Syndromes

    ·  Chapter 37 Psychopharmacologic Management in Oncology

    ·  Chapter 38 Management of Emesis

    ·  Chapter 39 Nutrition

    ·  Chapter 40 Pain and Palliative Care

    ·  Chapter 41 Central Venous Access Device

    ·  Chapter 42 Procedures in Medical Oncology

    ·  Chapter 43 Basic Principles of Radiation Oncology

    ·  Chapter 44 Clinical Genetics

    ·  Chapter 45 Basic Principles of Immuno-Oncology

    ·  Chapter 46 Anticancer Agents

    ·  Appendix: Performance Status Scales/Scores: Performance Status Criteria


  • Manual of Interventional Oncology
    La comanda in aproximativ 4 saptamani
    315.00 lei

    This Manual of Interventional Oncology by Douglas Coldwell is the culmination of more than 30 years of training, hands-on practice, and skills learned from oncology colleagues. The successful practice of interventional oncology (IO) requires familiarity with all cancer interventions, and the ability to recognize each of their strengths and weaknesses. Acquiring basic knowledge of all facets of the vast, ever-evolving cancer treatment paradigm enables greater understanding of how IO fits into the broad cancer management continuum.

    The first five chapters lay a solid foundation, detailing essentials of medical and surgical oncology and radiation, followed by interventional radiology cancer treatments and agents used in cancer chemotherapy. Twelve cancer-specific chapters cover tumor management and discussion of minimally invasive, imageguided tumor ablation techniques for each type of cancer, as well as IO for pain management and palliative care.

    Key Highlights

    • IO interventions for prevalent cancers such as colorectal, pancreatic, prostate, liver, bladder, breast, lung, and gynecologic - and less common pathologies including neuroendocrine tumors of the gastrointestinal tract and cholangiocarcinoma
    • More than 125 illustrations accompany succinct discussions of pathology, epidemiology, genetics, staging, treatment, outcomes, and IO options for each type of tumor
    • An overview of clinical trials provides a glimpse of future IO innovations
    • A road map to a successful IO career includes pearls gleaned from years of managing a thriving practice

    This definitive guide is a must-have for clinicians working in the field of vascular and interventional radiology. It provides interventional radiologists with the necessary building blocks, information, and techniques to thrive in this rapidly evolving specialty.

  • Viral Therapy of Human Cancers
    La comanda in aproximativ 4 saptamani
    320.00 lei

     Featuring contributions from nearly 30 leading authorities, this pioneering work gauges the potential for viruses to act as oncolytic and anti-tumor agents for the treatment of cancers in humans-detailing the cancer-combative properties exhibited by viruses in nature, genetically engineered viruses, and viral oncolysates as evidenced in basic and experimental studies.

  • 320.00 lei

     

    Now in its second edition, this bestselling title has been extensively revised and expanded to include new topics on:




    ·         obesity and breast cancer




    ·         induction of anti-hormone and anti-growth factor resistance in breast cancer




    ·         clinical implications of testosterone and breast cancer




    ·         insulin-like growth factors




    ·         discussions on the biological, genetic, and molecular pathways linked to the development and progression of breast cancer




    ·         analyses on the latest therapeutic strategies, prognostic and predictive factors, and prevention strategies




    Examining new developments, Breast Cancer: Prognosis, Treatment, and Prevention, Second Edition also covers:




    ·         the mechanism involved in carcinogenesis




    ·         the relationship among a fetus, pregnancy, and breast cancer




    ·         recent developments in endocrine treatment




    ·         the relationship among hormone replacement therapy, cytotoxic therapy, and other non-hormonal approaches for the treatment of metastases




    ·         management of locally advanced breast cancer, and the importance of BRCA-1 and BRCA-2 in hereditary breast cancer



    With new topics and updated chapters, this new edition keeps both oncologists and radiologists abreast of the current trends and advancements in the prognosis, treatment, and prevention of breast cancer.

     

  • 320.00 lei

     

    Breast cancers are now detected earlier and are thus more likely to be confined to the breast itself and regional nodes. Many of these tumours will have minimal proclivity for hematogenous dissemination and formation of micrometastases. On the other hand, some patients have micrometastatic diseases which can remain dormant and be activated many years after initial diagnosis.

     

    Early Breast Cancer: From Screening to Multidisciplinary Management discusses the principles and practice of breast cancer management with respect to both screen-detected and symptomatic disease. It provides readers with sound understanding and critical insight into many aspects of the disease from epidemiology, genetics, and screening to pathology, diagnosis, treatment, and prevention. This latest edition continues the general ethos of the second edition with an emphasis on early screening and continued development of the multidisciplinary team.

     

     

  • Molecular Imaging in Oncology
    La comanda in aproximativ 4 saptamani
    320.00 lei

     

    Description:

     

    With molecular imaging becoming one the fastest growing topics in medical schools, Informa Healthcare presents Molecular Imaging in Oncology, the first comprehensive reference on molecular imaging in oncology.Giving clinicians and researchers a greater understanding of the current field, this text covers:instrumentation and techniquescancer imaging

     

    Table of Contents:

     

    A Word on “Molecular Imaging”

    Foundations

    1. Tumor Biology

    2. Introduction to Molecular Biology

    3. Methods in Molecular Biology

    4. The Analysis of Complex Data Sets: Challenges and Opportunities

    Instrumentation

    5. Molecular PET Instrumentation and Imaging Techniques

    6. Molecular SPECT Imaging Instrumentation and Techniques

    7. Ultrasound Instrumentation and Techniques

    8. Oncological Applications of MR Spectroscopy

    9. Physiological and Functional Imaging with CT: Techniques and Applications

    10. Multimodality Imaging Instrumentation and Techniques

    Probe Design

    11. Targeted Agents for MRI

    12. High-Throughput Screening for Probe Development

    13. Radiopharmaceuticals for SPECT

    14. Radionuclides for Therapy

    15. CEST Contrast Agents

    16. Optical Imaging Probes

    17. Nanoparticle-Based Molecular Imaging in Living Subjects

    18. Long-Lived and Unconventional PET Radionuclides

    19. Design of New Imaging Agents Using Positron-Emitting Radionuclides as the Reporter

    20. Targeted Radiolabeled Receptor-Avid Peptides

    21. Targeted Ultrasound Contrast Agents

    Small Animal Imaging

    22. Quantification in Small-Animal PET and SPECT Imaging

    23. In Vivo Imaging Mouse Models of Breast Cancer

    24. Basics of Small Animal Handling for In Vivo Imaging

    Molecular-genetic Imaging

    25. Imaging Cellular Networks and Protein-Protein Interactions In Vivo

    26. Novel Reporter Probes for HSV1-tk Gene Expression

    27. Clinical Potential of Gene Expression Imaging

    28. Molecular-Genetic Imaging

    Cellular Processes

    29. Imaging Angiogenesis

    30. Imaging Apoptosis

    31. Imaging Cell Trafficking with MR Imaging

    32. General Considerations for Labeling and Imaging of Cells

    33. Molecular Imaging of the Extracellular Matrix and Lymphatic Phenomena in Tumors

    34. Nuclear Imaging of Adoptive Cell Therapies

    35. Optical Techniques for Imaging of Cell Trafficking

    Clinical Translation

    36. Radiopharmaceutical Therapy of Cancer

    37. Radioimmunodetection of Cancer: The Next Dimension

    38. Diffusion Magnetic Resonance Imaging for Cancer Treatment Response Assessment

    39. Molecular Imaging of Breast Cancer

    40. FDG PET/CT Imaging: Clinical Uses and Opportunities

    41. Molecular Imaging in Prostate Cancer

    Opportunities from Industry/Government

    42. Anticancer Drug Development with Optical Imaging

    43. Drug Development with Radiopharmaceuticals

    44. NIH Funding Sources for Molecular Imaging in Oncology

    45. Drug Development with Magnetic Resonance Imaging

    46. Industrial-Academic Collaboration

    47. The Future of Molecular Imaging

    Index

    Read Less

     

  • 320.00 lei

     

    Description:

     

    Lung cancer is the leading cause of cancer-related deaths in the United States. Filling a gap in the literature, this resource translates recent laboratory findings into practical applications for the prevention and control of lung cancer. Featuring chapters by seasoned researchers in the field, this reference reviews current advances in imaging, d

     

     

    Table of Contents:

     

    1. Molecular Biology of Lung Cancer as the Basis for Targeted Therapy

    2. Early Clinical Trial Design Issues: Patient Populations, End Points, and Barriers

    3. Antiangiogenic Therapy for Lung Cancer: Small-Molecule Inhibitors

    4. Antiangiogenic Therapy for Lung Cancer: Antibodies and Other Novel Agents

    5. Epidermal Growth Factor Receptor Inhibition in Non–Small Cell Lung Cancer

    6. Epidermal Growth Factor Receptor Targeted Therapy—Markers of Sensitivity and Response

    7. Other Novel Targeted Therapies in Lung Cancer

    8. Lung Cancer Vaccines

    9. Advances in Chemoradiation Treatment of Locoregionally Advanced Non–Small Cell Lung Cancer

    10. Advances in the Treatment of Brain Metastases

    11. Recent Advances in Imaging for Lung Cancer

     

  • 36500lei 330.00 lei

     

    Description:

    Modern brachytherapy is one of the most important oncological treatment modalities requiring an integrated approach that utilizes new technologies, advanced clinical imaging facilities, and a thorough understanding of the radiobiological effects on different tissues, the principles of physics, dosimetry techniques and protocols, and clinical expert

     

    Table of Contents:

     

    Chapter 1 - Introduction and Innovations in Brachytherapy

    Chapter 2 - Standard Technology in Brachytherapy

    Chapter 3 - Radionuclides in Brachytherapy: Current and Potential New Sources

    Chapter 4 - Quality Assurance of Equipment

    Chapter 5 - Source Calibration

    Chapter 6 - Experimental Dosimetry Methods

    Chapter 7 - Computational Methods for Dosimetric Characterization of Brachytherapy Sources

    Chapter 8 - Historical Development of Predictive Dosimetry “Systems”

    Chapter 9 - Two-, Three-, and Four-Dimensional Brachytherapy

    Chapter 10 - TG-43 Dose Calculation Formalism: Development, Insights, and Modernization

    Chapter 11 - On the Introduction of Model-Based Algorithms Performing Nonwater Heterogeneity Correct

    Chapter 12 - Optimization and Evaluation

    Chapter 13 - Quality Management of Treatment Planning

    Chapter 14 - Practical Use, Limitations, and Quality Control of Imaging in Brachytherapy

    Chapter 15 - Uncertainties Associated with Brachytherapy Source Calibrations and Dose Calculations

    Chapter 16 - Uncertainties Associated with Clinical Aspects of Brachytherapy

    Chapter 17 - Margin Concepts in Image- Guided Brachytherapy

    Chapter 18 - Clinical Use of Brachytherapy

    Chapter 19 - Radiobiology for Brachytherapy

    Chapter 20 - Brachytherapy for Prostate Cancer

    Chapter 21 - Brachytherapy for Gynecologic Cancers

    Chapter 22 - Brachytherapy for Breast Cancer

    Chapter 23 - Brachytherapy for Other Treatment Sites

    Chapter 24 - Developments in Gynecologic Brachytherapy Dose Recording and Reporting: From ICRU Repor

    Chapter 25 - In Vivo Dosimetry in Brachytherapy

    Chapter 26 - Special Brachytherapy Modalities

    Chapter 27 - Advanced Brachytherapy Technologies: Encapsulation, Ultrasound, and Robotics

    Chapter 28 - Intraoperative Brachytherapy

    Chapter 29 - Radiation Protection in Brachytherapy

    Chapter 30 - New Paradigm for Quality Management in Brachytherapy

    Chapter 31 - Quality Audits in Brachytherapy

    Chapter 32 - Expert Training in Brachytherapy

    Back Cover

     

  • 37500lei 338.00 lei

    Clinicians and scientists are increasingly recognising the importance of an evolutionary perspective in studying the aetiology, prevention, and treatment of human disease; the growing prominence of genetics in medicine is further adding to the interest in evolutionary medicine. In spite of this, too few medical students or residents study evolution. This book builds a compelling case for integrating evolutionary biology into undergraduate and postgraduate medical education, as well as its intrinsic value to medicine. Chapter by chapter, the authors - experts in anthropology, biology, ecology, physiology, public health, and various disciplines of medicine - present the rationale for clinically-relevant evolutionary thinking. They achieve this within the broader context of medicine but through the focused lens of maternal and child health, with an emphasis on female reproduction and the early-life biochemical, immunological, and microbial responses influenced by evolution. The tightly woven and accessible narrative illustrates how a medical education that considers evolved traits can deepen our understanding of the complexities of the human body, variability in health, susceptibility to disease, and ultimately help guide treatment, prevention, and public health policy. However, integrating evolutionary biology into medical education continues to face several roadblocks. The medical curriculum is already replete with complex subjects and a long period of training. The addition of an evolutionary perspective to this curriculum would certainly seem daunting, and many medical educators express concern over potential controversy if evolution is introduced into the curriculum of their schools. Medical education urgently needs strategies and teaching aids to lower the barriers to incorporating evolution into medical training. In summary, this call to arms makes a strong case for incorporating evolutionary thinking early in medical training to help guide the types of critical questions physicians ask, or should be asking. It will be of relevance and use to evolutionary biologists, physicians, medical students, and biomedical research scientists.

  • Imaging for Clinical Oncology
    Not yet published- 4 saptamani de la data aparitiei
    340.00 lei

     

    Imaging is a critical component in the delivery of radiotherapy to patients with malignancy, and this book teaches the principles and practice of imaging specific to radiotherapy.

    Introductory chapters outline the basic principles of the available imaging modalities including x-rays, CT, ultrasound, MRI, nuclear medicine, and PET. Site specific chapters then cover the main tumour sites, reviewing optimal imaging techniques for diagnosis, staging, radiotherapy planning, and follow-up for each site. The important areas of radiation protection, exposure justification, and risks are also covered, exploring issues such as balancing radiation exposure with long-term risks of radiation effects, such as second cancer induction.

    This second edition has been fully revised and updated to reflect current techniques, and includes two brand new chapters on imaging for radiotherapy treatment verification, and the role of specialist MRI techniques and functional imaging for radiotherapy planning. With insights from experts in each field and over 200 illustrations, this comprehensive and easy-to-read guide will be an invaluable resource for radiation oncologists, clinical oncologists, and radiotherapists, both qualified and in training.

     

  • 340.00 lei

     

    Description:

    This book, now in an extensively revised second edition, summarizes the basic principles of nuclear medicine and describes the clinical applications of commonly used nuclear medicine procedures and techniques. Readers will find clear explanation of clinical indications, the pathophysiological basis of functional procedures, and the complementary role of nuclear medicine and molecular imaging in relation to diagnostic radiology. Throughout, emphasis is placed on the added diagnostic value offered by the new hybrid imaging modalities. The various therapeutic applications of nuclear medicine are also discussed. Compared with the first edition, technical details have been significantly simplified. The book will be an ideal introduction to nuclear medicine for medical students and will serve as an excellent quick reference for referring physicians, enabling them to utilize this modern medical specialty more efficiently.

     

    Table of Contents:

     

    1. Basic Principles of Nuclear Medicine

    2. Nuclear Medicine in the Genitourinary System

    3. Nuclear Medicine in the Digestive System

    4. Nuclear Medicine in the Endocrine System

    5. Nuclear Medicine in Soft-Tissue Infection and Inflammation

    6. Nuclear Medicine in the Respiratory System

    7. Nuclear Medicine in the Musculoskeletal System

    8. Nuclear Medicine in the Cardiovascular System

    9. Nuclear Medicine in the Nervous System

    10. Nuclear Medicine in Oncology

    11. Therapeutic Applications of Nuclear Medicine

     

  • 40000lei 345.00 lei

    Carte tiparita la comanda!

    Description:

    This issue of Surgical Oncology Clinics of North America, edited by Dr. Lawrence Wagman, is devoted to Hepatocellular Cancer, Cholangiocarcinoma, and Metastatic Tumors of the Liver. Articles in this issue include: Epidemiology of Hepatomas; Risk Modeling: disease prevalence, outcome from treatment; Imaging; Resection techniques; Ablation techniques; Complications of interventions; Trans-arterial chemo-embolization (TACE); Continuous hepatic artery infusion (CHAI); Selective interstitial radiation therapy (SIRT) and External beam radiation therapy (EBRT); Systemic chemotherapy of HCC and Cholangiocarcinoma; and Systemic chemotherapy and CRC metastases.

     Table of Contents:

    ·  Contributors

    ·  Consulting Editor

    ·  Editor

    ·  Authors

    ·  Forthcoming Issues

    ·  Forthcoming Issues

    ·  Recent Issues

    ·  Foreword: Hepatocellular Cancer, Cholangiocarcinoma, and Metastatic Tumors of the Liver

    ·  Preface: Hepatocellular Cancer, Cholangiocarcinoma, and Metastatic Tumors of the Liver

    ·  Epidemiology of Hepatocellular Carcinoma

    ·  Key points

    ·  Introduction

    ·  Incidence

    ·  Risk factors

    ·  Patient factors

    ·  Economic/public health aspect

    ·  Summary

    ·  Imaging Approach to Hepatocellular Carcinoma, Cholangiocarcinoma, and Metastatic Colorectal Cancer

    ·  Key points

    ·  Introduction

    ·  Liver imaging modalities

    ·  Imaging liver lesions

    ·  Summary

    ·  Prognostication Systems as Applied to Primary and Metastatic Hepatic Malignancies

    ·  Key points

    ·  Introduction

    ·  Primary hepatic malignancies

    ·  Hepatic colorectal adenocarcinoma metastases

    ·  Summary

    ·  Modern Technical Approaches in Resectional Hepatic Surgery

    ·  Key points

    ·  Introduction

    ·  Indications for liver resection

    ·  Preoperative functional evaluation

    ·  Anatomy and terminology of liver resection

    ·  Technical considerations and outcomes after liver surgery

    ·  Positioning and setup

    ·  Incisions and retraction

    ·  Intraoperative ultrasonography

    ·  Hepatic mobilization

    ·  Approach to inflow control

    ·  Approach to outflow control

    ·  Techniques of parenchymal transection

    ·  Specific procedures

    ·  Complications Following Hepatectomy

    ·  Key points

    ·  Post-hepatectomy hemorrhage

    ·  Post-hepatectomy venous thrombosis/thromboembolism

    ·  Post-hepatectomy portal vein and hepatic artery thrombosis

    ·  Bile leak

    ·  Post-hepatectomy liver failure

    ·  Summary

    ·  Ablative Technologies for Hepatocellular, Cholangiocarcinoma, and Metastatic Colorectal Cancer of the Liver

    ·  Key points

    ·  Introduction

    ·  Ablation technologies

    ·  Patient selection

    ·  Ablation approaches

    ·  Perioperative process

    ·  Outcomes

    ·  Hepatic Artery Infusion Chemotherapy for Liver Malignancy

    ·  Key points

    ·  Introduction

    ·  Technical aspects

    ·  Management of variant hepatic arterial anatomy

    ·  Postoperative management and treatment surveillance

    ·  Complications

    ·  Clinical outcomes with hepatic artery infusion chemotherapy

    ·  Unresectable colorectal cancer metastases

    ·  Hepatic artery infusion chemotherapy and primary liver tumors

    ·  Hepatic artery infusion chemotherapy and noncolorectal liver metastases

    ·  Summary

    ·  Transarterial Chemoembolization for Primary Liver Malignancies and Colorectal Liver Metastasis

    ·  Key points

    ·  Introduction

    ·  Principles of transarterial chemoembolization

    ·  Hepatocellular carcinoma

    ·  Intrahepatic cholangiocarcinoma

    ·  Metastatic colorectal carcinoma to the liver

    ·  Summary

    ·  Y90 Selective Internal Radiation Therapy

    ·  Key points

    ·  Introduction

    ·  Outcomes

    ·  Complications

    ·  Summary

    ·  Systemic Therapy for Hepatocellular Carcinoma and Cholangiocarcinoma

    ·  Key points

    ·  Scope of the problem

    ·  Hepatocellular carcinoma

    ·  Sorafenib

    ·  Challenges with treatment

    ·  Failure of clinical trials

    ·  Liver-directed therapy and sorafenib

    ·  Cholangiocarcinoma

    ·  Summary

    ·  Integrating Systemic and Surgical Approaches to Treating Metastatic Colorectal Cancer

    ·  Key points

    ·  Introduction

    ·  Systemic regimens for metastatic colorectal cancer

    ·  Maintenance regimens

    ·  Potentially curable advanced colorectal cancer

    ·  Role for resection of primary tumor

    ·  Summary and future directions

  • 43000lei 345.00 lei

     Carte tiparita la comanda!



    Proposed topics for this issue include: Overview of Colorectal Cancer Genetics; Familial Adenomatous Polyposis; MYH Associated Polyposis; Other genetic colorectal cancer syndromes; Hereditary Nonpolyposis Colorectal Cancer – emphasis on MSH2/MLH1; Hereditary Nonpolyposis Colorectal Cancer – emphasis on PMS2/MSH6; Familial Colorectal Cancer Syndrome Type X; Genome Wide Association Studies and Colorectal Cancer Risk; Genetic Counseling for Hereditary Colorectal Cancer; Genetic Testing for Hereditary Colorectal Cancer; Role of surgery in HNPCC and FAP.

  • 350.00 lei

    For more than 30 years, Skeel’s Handbook of Cancer Therapy (formerly Handbook of Cancer Chemotherapy) has been the resource of choice for current, reliable information on cancer treatment for most adults. The 9th Edition reflects recent significant advances in the systemic treatment of cancer, including innovations in immunotherapy, oncology genomics, and molecular targeted therapy. An invaluable reference for all levels of physicians, nurses, and allied health professionals who provide care to cancer patients, this bestselling guide combines the most current rationale and the details necessary to safely administer pharmacologic therapy, offering a balanced synthesis between science and clinical practice. · A new chapter on the Biologic Basis of Molecular Targeted Therapy, as well as a state-of-the-art review of the current development and use of novel immunotherapeutics, bring you up to date with the rationale and use of these newer agents in cancer treatment. · Completely updated throughout to reflect current best practices, including primary indications, usual dosage and schedule, special precautions, and expected toxicities for dozens of new drugs and biologic agents. · New contributors provide a fresh perspective on timely topics in cancer treatment and care. · An updated section on supportive care reflects this essential aspect of the oncology team’s focus. · Regularly updated Inkling content keeps you current with drug profiles and new immunotherapy advances. Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like: · Complete content with enhanced navigation · Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web · Cross-linked pages, references, and more for easy navigation · Highlighting tool for easier reference of key content throughout the text · Ability to take and share notes with friends and colleagues · Quick reference tabbing to save your favorite content for future use

  • 40000lei 358.00 lei

    Carte tiparita la comanda!


    Description:

    This issue of Surgical Oncology Clinics of North America, edited by Dr. John Ridge, is devoted to Head and Neck Cancer.Articles in this issue include: Epidemiology of Head and Neck Cancer; Molecular Biology and Immunology; Examination of the patient with Head and Neck Cancer; Imaging of Head and Neck Cancer; Principles of Radiation Treatment; Principles of Chemotherapy; Principles and Practice of Reconstructive Surgery; Oral Cavity; Oropharynx; Unknown primary; Larynx and Hypopharynx; Nasopharynx; Nose and Sinus; Head and Neck Skin Cancer; and Tumors of the major Salivary Glands.

     

     Table of Contents:

    ·  Copyright

    ·  Contributors

    ·  Consulting Editor

    ·  Editor

    ·  Authors

    ·  Forthcoming Issues

    ·  Forthcoming Issues

    ·  Recent Issues

    ·  Foreword: A Long Overdue Discussion of Head and Neck Cancer

    ·  Preface: Why “Head and Neck Cancer”?

    ·  Epidemiology of Head and Neck Cancer

    ·  Key points

    ·  Introduction

    ·  Risk factors for head and neck cancer

    ·  Trends in head and neck cancer incidence

    ·  Prognosis

    ·  Summary

    ·  Molecular Biology and Immunology of Head and Neck Cancer

    ·  Key points

    ·  Distinct etiologic subsets of head and neck squamous cell carcinoma

    ·  Genetic alterations

    ·  Major pathways

    ·  Examination of the Patient with Head and Neck Cancer

    ·  Key points

    ·  History taking in the head and neck

    ·  Overall function

    ·  Physical examination

    ·  Special considerations by anatomic site

    ·  Summary

    ·  Radiation Treatment of Head and Neck Cancer

    ·  Key points

    ·  Introduction

    ·  Technical principles of modern head and neck radiation therapy

    ·  Clinical evidence in support of highly conformal therapy

    ·  Results of induction and concurrent chemoradiation

    ·  Uniquely evolving issues in oropharyngeal carcinoma

    ·  Posttreatment surveillance

    ·  Postradiation resection

    ·  Sequencing of other therapies around surgery

    ·  Future advances in radiation therapy

    ·  Summary

    ·  Systemic Therapy for Squamous Cell Carcinoma of the Head and Neck

    ·  Key points

    ·  Systemic therapy for localized disease

    ·  Postoperative chemoradiation for squamous cell cancer of the head and neck

    ·  Palliative systemic therapy for recurrent and metastatic disease

    ·  Current investigational approaches

    ·  Summary

    ·  Imaging for Head and Neck Cancer

    ·  Key points

    ·  Head and neck cancer

    ·  Rationale for modality selection

    ·  Diagnostic imaging technique

    ·  Interpretation/assessment of clinical images

    ·  Summary

    ·  Principles and Practice of Reconstructive Surgery for Head and Neck Cancer

    ·  Key points

    ·  Patient evaluation overview

    ·  Soft tissue reconstruction

    ·  Maxilla reconstruction

    ·  Tongue reconstruction

    ·  Mandible reconstruction

    ·  Pharyngeal reconstruction

    ·