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  • Oxford Handbook of Rheumatology
    La comanda in aproximativ 4 saptamani
    21400lei 190.00 lei

    The Oxford Handbook of Rheumatology, 4th edition has been fully reviewed and updated to make it into an invaluable guide for students, trainees, consultant rheumatologists, and everyone caring for patients with musculoskeletal disease. With the addition of a paediatric rheumatologist to the editor team, this new edition is a fully functional rheumatology handbook for patients from childhood to adulthood.

    Practically structured, the handbook focuses first on presenting symptoms and then considers key diseases, emergencies, and rare diseases in detail. There is a comprehensive and updated account of assessment, guidelines, and treatment options. The text has been condensed with bullet points and summary boxes so the reader can focus on the essential information. To aid understanding over half of the images have been updated and the colour plate section has been expanded.

    Taking a clinical, evidence-based approach, written by experts, and presented in a clear, practical, bullet-point style for rapid reference, this handbook will be your constant companion and a joy to use.

  • 30500lei 270.00 lei


    ·         Covers the full spectrum of paediatric rheumatology presentations

    ·         Provides the relevant clinical guidelines and information needed to successfully manage a young patient

    ·         Includes a colour plate section for guidance on rashes in rheumatological conditions

    New to this Edition:

    ·         Fully revised and updated

    ·         New contributions from international experts

    ·         New contributions to reflect recommendations and standards of care

    ·         Extensively updated section on monogenic autoinflammatory diseases

    ·         Updated consensus treatment guidelines for systemic inflammatory conditions including Kawasaki disease, other systemic vasculitides, autoinflammatory diseases, and rarer connective tissue disorders


    Table of Contents

    1: Clinical skills and assessment
    2: Common and important clinical problems
    3: Juvenile idiopathic arthritis
    4: Systemic Diseases
    5: Bone diseases, skeletal dysplasias, disorders of collagen
    6: Infection and Immunization
    7: The multidisciplinary approach to management
    8: Specialized therapeutic approaches
    9: Clinical guidelines and protocols
    10: Rashes in Paediatric Rheumatology


  • Atlas of Rheumatoid Arthritis
    La comanda in aproximativ 4 saptamani
    31500lei 280.00 lei



    Atlas of Rheumatoid Arthritis is a high-quality educational initiative, written by leaders in the field of rheumatology, containing a collection of approximately 150 relevant images, with extended descriptive captions and a comprehensive bibliography. The Atlas of Rheumatoid Arthritis will provide clinicians with a visual guide to rheumatoid arthritis, focusing on assessment, diagnosis and treatment, including newer research into the signalling pathways involved in the pathogenesis of RA, before focusing on the treatment of RA. Rheumatoid arthritis (RA) is the most common and most serious of the inflammatory arthritic disorders, and it dominates clinical rheumatological practice. Effective, early treatment is vital as this can slow the course of the disease and reduce joint damage. RA is usually treated using disease-modifying anti-rheumatic drugs (DMARDs), most commonly methotrexate. The newest treatments target the disease-causing immune elements specifically and directly.


    Table of Contents:


    PART ONE Rheumatoid arthritis overview

    1 Classification of rheumatoid arthritis


    2 Pre- rheumatoid arthritis

    What is pre-rheumatoid arthritis?

    Risk factors for rheumatoid arthritis

    Systemic autoimmunity associated with rheumatoid arthritis

    Symptoms without clinical arthritis

    Unclassified arthritis


    3 Early rheumatoid arthritis


    Pathology in early rheumatoid arthritis

    Diagnosis of early rheumatoid arthritis

    Classification of rheumatoid arthritis

    Management of early rheumatoid arthritis

    Recommendations for the management of early rheumatoid arthritis


    4 Established rheumatoid arthritis


    Stages of established rheumatoid arthritis

    Common clinical presentations


    5 Remission and rheumatoid arthritis


    Defining remission

    Imaging remission

    Immune-mediated remission

    Drug-free remission

    Optimal dose reduction regimes for patients in remission


    PART TWO Imaging of rheumatoid arthritis

    6 Magnetic resonance imaging in rheumatoid arthritis


    Technical aspects

    Visualizing rheumatoid arthritis

    Diagnosing rheumatoid arthritis

    Monitoring disease activity and structural damage


    7 Ultrasound imaging in rheumatoid arthritis


    Ultrasound and rheumatoid arthritis

    Cartilage damage

    Management of rheumatoid arthritis with ultrasound: diagnosis,therapeutic follow-up, remission, and



    8 Dual energy X-ray absorptiometry in rheumatoid arthritis


    Bone remodeling in rheumatoid arthritis

    Bone damage imaging in rheumatoid arthritis

    Treatment of bone loss in rheumatoid arthritis


    PART THREE Treatment of rheumatoid arthritis

    9 Methotrexate


    Historical perspective

    Mechanism of action and pharmacokinetics




    Side effects


    10 Immunotherapy


    Nonbiologic disease-modifying antirheumatic drugs

    Biologic disease-modifying antirheumatic drugs

    Cost-effectiveness of immunotherapy in early rheumatoid arthritis

    Recommendations for the use of disease-modifying antirheumatic drug therapies

    Safety of immunotherapy

    Prospective new targets for immunotherapy


    11 Rituximab

    B-cell development and differentiation

    Efficacy of rituximab in rheumatoid arthritis

    12 Novel therapies in rheumatoid arthritis: small molecules


    Inhibiting intracellular signaling pathways



  • Biologics for the Treatment of Rheumatoid Arthritis
    La comanda in aproximativ 4 saptamani
    31500lei 280.00 lei




    This book provides a comprehensive overview of the available biologic therapies whilst comparing them to standard disease modifying anti-rheumatic drugs, and discusses how best to determine which therapy is most appropriate for an individual patient in the framework of current guidelines. Biologics for the Treatment of Rheumatoid Arthritis is an up-to-date and concise practical guide to the latest therapeutic developments in this field. This book is an invaluable source of topical information for all rheumatologists and health care professionals treating patients with rheumatoid arthritis.


    Table of Contents:


    1 Disease overview

    Clinical presentation

    Etiology and pathogenesis

    Pathophysiology of joint inflammation in rheumatoid arthritis

    Diagnosis and classification

    Long-term complications of rheumatoid arthritis


    2 General treatment aspects

    Goals of treatment

    Measuring disease activity and treatment response

    Overview of treatment approaches

    Overview of the non-biologic treatments for rheumatoid arthritis


    3 Overview of biologic therapies

    Brief historical review of the emergence of biologics for rheumatoid arthritis

    Overview of currently available biologic therapies

    Biologic versus synthetic disease modifying antirheumatic drugs: similarities and differences

    Current guidelines for biologic use in rheumatoid arthritis


    4 Cytokine inhibitors

    Tumor necrosis factor inhibitors

    Interleukin-6 inhibitors

    Interleukin-1 inhibitors


    5 B-cell directed therapy


    Overview of B-cell therapy for rheumatoid arthritis


    6 T-cell directed therapy

    Overview of T-cell directed therapy for rheumatoid arthritis


    7 Novel biologics and small molecules with biologic-like effects


    Novel biologics

    Novel synthetic antirheumatic medications with biologic-like properties


    8 Strategies for the optimal use of biologic agents in rheumatoid arthritis


    Treatment of the patient with an inadequate response to methotrexate

    Treatment of the patients with newly diagnosed methotrexate-naive rheumatoid arthritis

    Induction-maintenance strategies in rheumatoid arthritis

    Switching after failing an anti-tumor necrosis factor

    Dose optimization with biologics: dosing up,dosing down

    Head-to-head comparative studies of biologic agents

    Determining which therapy is most appropriate for an individual patient: personalized therapy


    9 Considerations for special patient populations

    Special considerations in the pregnant patient

    Special considerations in the pediatric patient

    Special considerations in the elderly patient


    10 Conclusions and future outlook

    Historical perspective

    Future perspective

    Future prospects for treatment strategies in rheumatoid arthritis: ‘treating to target’




  • 35200lei 315.00 lei




    This book presents concise, comprehensive summaries of topics necessary to understand rheumatoid arthritis (RA) management, aligned with patient needs, as a reference suitable for practitioners and students of all levels. Special attention is paid to the innovative RhMAT (Rheumatoid Arthritis Medication Assessment Tool), in addition to descriptions of the pharmacological management of RA, pharmacoeconomic and pharmacovigilance considerations, the benefits of seamless care, and case presentations.Rheumatoid arthritis is one of the most common forms of inflammatory arthritis in the world, with a prevalence of 0.5 to 1%. While no cure has yet been established, modern biotechnology has enabled highly effective management, if treatment begins early. However, cost and side effects, such as immune suppression, continue to present barriers, and monitoring of patients is pivotal to safe and effective disease management.
    Both hospital and community pharmacists are involved in RA patient management, and have responsibilities to this patient population.  Identifying pharmaceutical care issues and ensuring that the patients are managed in accordance to best evidence-based medicine are paramount. Best care is delivered when pharmacists effectively communicate with each other, the prescribers and the multidisciplinary team members involved in the care of the patient. This book aims to tackle the various aspects of the management of RA patients across all the settings.


    Table of Contents:


    Understanding Rheumatoid Arthritis

    Pages 1-18

    Mallia, Carmel, MD, FRCP (Lond., EDIN.) (et al.)


    Pharmacotherapy of Rheumatoid Arthritis

    Pages 19-37

    Bayraktar-Ekincioglu, Aygin, PhD (et al.)


    Pharmacoeconomics and Rheumatoid Arthritis

    Pages 39-52

    Zarb Adami, Maurice, PhD (et al.)


    Pharmaceutical Care Issues of Rheumatoid Arthritis Patients

    Pages 53-69

    Azzopardi, Lilian M., PhD (et al.)

    Transitional Care: Caring Across the Interface

    Pages 71-78

    Farrugia, Karen, BPharm (Hons) (Melit) (et al.)




  • 43000lei 390.00 lei



    There are numerous monographs devoted to rheumatoid arthritis. What sets this issue apart is that it keeps an eye to the future. Topics explored include measurement of RA disease activity today and in the future; epidemiology of RA – implications for prevention and risk assessment; genes that predispose to RA – relevance to current and future therapeutic strategies; multiple kinases – assessment of the best targets in treating RA; assessment, prevention and treatment of cardiovascular morbidity in RA; mechanistic insights and approaches to prevention of bone damage in RA; cell-cell interactions in RA synovium as potential new targets for treatment; alternative strategies for modulating the function of B lymphocytes in RA; innate immunity in RA; ascertainment and management of preclinical RA.


    Table of Contents:


    Forthcoming Issues


    Preclinical Rheumatoid Arthritis: Identification, Evaluation, and Future Directions for Investigation

    How Should Rheumatoid Arthritis Disease Activity Be Measured Today and in the Future in Clinical Care?

    Leveraging Human Genetics to Develop Future Therapeutic Strategies in Rheumatoid Arthritis

    Innate Immunity and Rheumatoid Arthritis

    Immune Aging and Rheumatoid Arthritis

    Cell-cell Interactions in Rheumatoid Arthritis Synovium

    B Cell Therapies for Rheumatoid Arthritis: Beyond B cell Depletion

    Targeting IL-17 and Th17 Cells in Rheumatoid Arthritis

    A Multitude of Kinases—Which are the Best Targets in Treating Rheumatoid Arthritis?

    Bone Damage in Rheumatoid Arthritis: Mechanistic Insights and Approaches to Prevention

    Cardiovascular Complications of Rheumatoid Arthritis: Assessment, Prevention, and Treatment


  • Axial Spondyloarthritis, 1e
    La comanda in aproximativ 4 saptamani
    45900lei 410.00 lei

     Focusing on the key essentials you need to know, Axial Spondyloarthritis provides a quick, expert overview of axSpA from a clinical perspective. This concise resource by Drs. Philip Mease and Muhammad Khan presents practical recommendations and guidelines for the diagnosis, management, and treatment of spondyloarthritis impacting the axial skeleton alongside an overview of epidemiology, special populations, and patient education.

    • Discusses key information on genetic factors and disease biomarkers.
    • Presents an overview of clinical features, classification criteria, and imaging to aid in diagnosis.
    • Covers management and treatment guidelines, including non-pharmacologic management and the use of biologics.
    • Consolidates essential information on this timely topic into a single, convenient resource.

  • Gout
    La comanda in aproximativ 4 saptamani
    47800lei 410.00 lei

    Concise and clinically focused, Gout, by Drs. Naomi Schlesinger and Peter E. Lipsky, provides a one-stop overview of recent developments regarding this common form of inflammatory arthritis. Impacting an estimated 8.3 million people in the U.S. alone, gout is seen frequently by both primary care physicians as well as rheumatologists. This resource provides detailed coverage of the epidemiology, causes, diagnosis, management, and treatment of patients with both acute and chronic gout. Features: Addresses key topics such as genetics, hyperuricemia, comorbidities of gout, treatment guidelines for acute and chronic gout, classification and diagnosis, and imaging. Discusses future outlooks for improving pharmacological and nonpharmacological treatment options, including an overview of drugs in the pipeline. Consolidates today's available information on this timely topic into one convenient resource.

  • 450.00 lei

    Rhumatologie pour les th�rapeutes manuels Kin�sith�rapeutes, Ost�opathes, Chiropracteurs �ternelle question de tout enseignant : o� placer la barre du savoir d�livr� en fonction du public vis� ? Que dois-je dire du m�tabolisme du calcium � l'�l�ve kin�sith�rapeute ou � l'�tudiant en m�decine, � l'interne se sp�cialisant en rhumatologie, au m�decin g�n�raliste ou au chirurgien orthop�diste ? Jusqu'o� descendre dans le d�tail pour ceux-ci, comment �purer l'essentiel pour ceux-l� ? La r�ponse apport�e varie selon les enseignants

  • 60400lei 550.00 lei




    This volume provides a summary of the standard laboratory protocols and methodology commonly used in basic and translational studies in the field of rheumatoid arthritis (RA) treatment. Chapters detail including basic RA models, evaluation of disease activity and immunological status, systemic drug delivery, and new research tools. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

     Authoritative and cutting-edge, Rheumatoid Arthritis: Methods and Protocols aims to be a basic manual for clinical researchers who are just getting started in the field of intervention study.


    Table of contents:


    Collagen-Induced Arthritis Models

    Pages 3-7

    Miyoshi, Maya (et al.)


    Human Xenograft Model

    Pages 9-15

    Liu, Shuang


    Long-Term Constant Subcutaneous Drug Administration

    Pages 17-22

    Liu, Shuang (et al.)


    Clinical Scoring of Disease Activity in Animal Models

    Pages 23-28

    Miyoshi, Maya (et al.)


    Histological Analysis of Arthritic Joints

    Pages 29-39

    Kiyoi, Takeshi


    Preparation of Joint Extracts

    Pages 41-45

    Liu, Shuang (et al.)


    Production of Immunizing Antigen Proteoliposome Using Cell-Free Protein Synthesis System

    Pages 49-67

    Zhou, Wei (et al.)


    Reconstruction of Protein/Liposome Complex

    Pages 69-77

    Suzuki, Yasuyuki


    Production of Neutralizing Antibody

    Pages 79-92

    Takemasa, Erika (et al.)


    Autoantibody Profiling Using Human Autoantigen Protein Array and AlphaScreen

    Pages 93-112

    Takeda, Hiroyuki


    Generation of Specific Aptamers

    Pages 113-121

    Liu, Shuang (et al.)


    Production of Lentiviral Particles

    Pages 123-128

    Liu, Shuang


    RNA Interference Ex Vivo

    Pages 129-135

    Liu, Shuang


    Lentiviral-Mediated Systemic RNA Interference In Vivo

    Pages 137-144

    Liu, Shuang


    Mesenchymal Stem Cell Engineering

    Pages 145-150

    Liu, Shuang


    Screening of Ca2+ Influx in Lymphocytes

    Pages 153-159

    Takemasa, Erika (et al.)


    Single-Cell Ca2+ Imaging

    Pages 161-168

    Liu, Shuang


    Electrophysiological Methods to Measure Ca2+ Current

    Pages 169-176

    Liu, Shuang (et al.)


    The Functional Assessment of T cells

    Pages 177-199

    Maruyama, Saho


    Release of Antibodies and Cytokines from B Cells

    Pages 201-207

    Liu, Shuang


    Evaluation of Autoreactive Responses

    Pages 209-213

    Liu, Shuang


    Bone Resorption Activity in Mature Osteoclasts

    Pages 215-222

    Kiyoi, Takeshi


    Animal Models of Vasculitis

    Pages 223-232

    Mogi, M. (et al.)


    Design an Intervention Study

    Pages 235-241

    Hasegawa, Hitoshi


    Assessment of Disease Activity, Structural Damage, and Function in Rheumatoid Arthritis

    Pages 243-250

    Hasegawa, Hitoshi


    Correction to : Production of Lentiviral Particles

    Pages E1-E1

    Liu, Shuang





  • 640.00 lei

    Les gestes en rhumatologie 3e �dition Apr�s le grand succ�s remport� par les �ditions pr�c�dentes, il �tait indispensable d'actualiser et de compl�ter ce travail sans �quivalent dans la litt�rature francophone. Cette nouvelle �dition est enrichie par un chapitre sur l'int�r�t et l'efficacit� des infiltrations en intra-articulaire sp�cifi�s pour chaque appareil anatomique, un chapitre sur les infiltrations �choguid�es ainsi que les cotations interventionnelles en �chographie et un chapitre sur les associations de produits en intra-articulaire. Le chapitre Pr�vention des infections associ�es aux infiltrations a �t� enti�rement revu. Les gestes locaux, qu'ils soient pratiqu�s au cabinet ou en structure institutionnelle - h�pital ou clinique - valorisent l'activit� du rhumatologue. La rhumatologie est une sp�cialit� dont l'aspect technique est actuellement insuffisamment pris en compte. Cette activit� th�rapeutique et diagnostique, exerc�e par un m�me praticien, est rassurante, valorisante et coh�rente pour le patient et le m�decin. Un des objectifs de cet ouvrage est d'accompagner le praticien dans la r�alisation de ces gestes locaux et de lui apporter un compl�ment de formation. Pour chacun des gestes expliqu�s, nous rappelons le but, les indications, le mat�riel n�cessaire, la nouvelle nomenclature des actes m�dicaux, la technique et les �ventuels complications. Pour certains gestes, une fiche de technique sous �cho-guidage �labor�e par Roland Hamisultane, ainsi qu'une fiche d'informations aux patients est propos�e.

  • 650.00 lei


     Imaging in Rheumatology: A Clinical Approach is ideal for radiologists and rheumatologists-as well as orthopedic surgeons and others interested in applying imaging to rheumatologic diseases-and stresses conventional radiography as the most effective imaging assessment technique to help diagnose various diseases and conditions. Greenspan and Gershwin-a radiologist and rheumatologist, respectively-focus on practical, everyday use, so you can apply knowledge you learn in any clinical setting. Features:Clearly and comprehensively details clinical, pathological, and imaging assessment of rheumatic diseases and conditions like arthritides and arthropathies.Trains radiologists learn how imaging fits into diagnostic processes-and non-radiologists how to better understand imaging techniques.Designed for practical, everyday use in clinical situations with patients.Chapters in the core middle section present clinically relevant and practical overviews of a disease or condition, accompanied by illustrated imaging features of that condition.Helps you recognize a disease process masquerading as arthritis.Your book purchase includes a complimentary download of the enhanced eBook for iOS, Android, PC & Mac. Take advantage of these practical features that will improve your eBook experience:The ability to download the eBook on multiple devices at one time - providing a seamless reading experience online or offline.Powerful search tools and smart navigation cross-links that allow you to search within this book, or across your entire library of VitalSource eBooks.Multiple viewing options that enable you to scale images and text to any size without losing page clarity as well as responsive design.The ability to highlight text and add notes with one click.

  • 72200lei 650.00 lei




    This brand new textbook of rheumatoid arthritis (RA) is an important addition to the Oxford Textbooks in Rheumatology series, and provides a comprehensive overview of both the scientific and clinical aspects of the disease. Divided into eight sections - from the history, diagnosis, and epidemiology of the disease, through the pathogenesis, clinical presentation, and assessment to treatments and management strategies, both drug- and non-drug based - each chapter is written by leading clinicians and scientists in the field to deliver a contemporary view of RA.

    During the past two decades there have been revolutionary changes in the understanding and management of rheumatoid arthritis, in particular the development of biological treatments. This has had wide-ranging effects on almost all aspects of treatment, from effectiveness and intensity to the nature and the cost. Providing a comprehensive account of the modern ideas about the disease, the Oxford Textbook of Rheumatoid Arthritis is a key new addition to the literature, with each chapter providing a detailed background, key recent advances, and areas of doubt and future developments.

    Featuring over 170 photographs, radiological images, and clinical charts to aid both diagnosis and illustrate the rationale behind key scientific studies, this new title will prove an indispensable resource for specialist rheumatologists, trainees in rheumatology, and other members of the multi-disciplinary team.




  • 720.00 lei

    •             A complete revision of the classic reference text in the field contains all you ned to know in one comprehensive volume

                 Along with new information on drug therapies, pathology, and imaging, the text now contains full colour illustrations which enhance the learning experience

                 Authored by international experts in the field, presenting a comprehensive world view

    The field of rheumatology has undergone numerous exciting advances in recent years, especially the development of biological drugs with novel targets, made possible by rapid advances in the basic science of musculoskeletal diseases together with improved imaging techniques. This thoroughly revised fourth edition of the Oxford Textbook of Rheumatology reflects the changing face of the specialty and the many recent advances in the science, treatment, and understanding of rheumatic diseases.

    The focus of this comprehensive reference work is the presentation and management of rheumatic conditions at all ages. Where relevant, treatment approaches are evidence-based and cross-referenced to national and international guidelines. Each clinical chapter provides up-to-date treatment advice illustrated with clinical vignettes as appropriate, and the authors consistently emphasize the overlap of rheumatology with other disciplines. With full colour illustrations throughout and a complementary online version, the Oxford Textbook of Rheumatology, Fourth Edition is an essential reference for all trainees and specialists in the field.

  • 725.00 lei


    • ​​​Serves as an up-to-date guide for diagnosing and monitoring a wide range of rheumatic diseases using musculoskeletal ultrasound
    • Provides numerous color figures, examples, check-off lists, and step-by-step scanning instructions
    • With contributions by international experts in rheumatology and musculoskeletal ultrasound

    About this book

    This book is a practical and evidence-based guide to performing clinical musculoskeletal ultrasound for patients suffering from various rheumatic diseases. It represents the best current thinking on the role of ultrasonography in the assessment of pathology, diagnosis and treatment of these disorders. Following introductory chapters covering fundamental techniques and pitfalls of musculoskeletal ultrasound, the book discusses the uses of ultrasound to identify and monitor different rheumatic conditions, including rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, pediatric musculoskeletal disorders, carpal tunnel syndrome and inflammatory conditions. It concludes with a chapter dedicated to ultrasound-guided interventional procedures, with illustrations depicting patients and probe positioning. Featuring contributions from a large international group of leaders in musculoskeletal ultrasonography, Musculoskeletal Ultrasonography in Rheumatic Diseases is an authoritative reference for rheumatologists, sonographers, radiologists and orthopedic specialists.


    Table of contents (14 chapters)

    ·         Fundamentals of Musculoskeletal Ultrasound

    El-Azizi, Hatem (et al.)

    Pages 1-20

    ·         Pitfalls in Musculoskeletal Ultrasound

    Vlad, Violeta Maria

    Pages 21-55

    ·         Rheumatoid Arthritis

    Naredo, Esperanza (et al.)

    Pages 57-87

    ·         Ankylosing Spondylitis

    Backhaus, Marina (et al.)

    Pages 89-106

    ·         Psoriatic Arthritis

    Acebes, Carlos (et al.)

    Pages 107-122

    ·         Osteoarthritis

    Iagnocco, Annamaria (et al.)

    Pages 123-135

    ·         Crystal-Induced Arthritis

    Nestorova, Rodina (et al.)

    Pages 137-167

    ·         Skin, Nail, and Hair in Rheumatology

    Wortsman, Ximena

    Pages 169-185

    ·         Pediatric Musculoskeletal Disorders

    Collado Ramos, Paz (et al.)

    Pages 187-205

    ·         Carpal Tunnel Syndrome

    El Miedany, Yasser

    Pages 207-237

    ·         Soft Tissue Rheumatism

    Khalil, Adham Aboul Fotouh (et al.)

    Pages 239-269

    ·         Inflammatory Allied Conditions

    Oliveira, Margarida Alexandre (et al.)

    Pages 271-313

    ·         Sports Medicine

    Czyrny, Zbigniew

    Pages 315-338

    ·         Ultrasound-Guided Interventional Maneuvers

    Micu, Mihaela C. (et al.)

    Pages 339-385

  • 88200lei 735.00 lei

    For more than 50 years, Dubois' Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It's an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes. Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients. Offers an increased focus on the clinical management of related disorders such as Sjogren's syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS). Presents the knowledge and expertise of more international contributors to provide new global perspectives on manifestations, diagnosis, and treatment. Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, and more schematic diagrams throughout. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

  • 735.00 lei

     Pret: 735 lei 460 lei (pret valabil pana la data de 25 septembrie 2020)



    Features schematic diagrams of gene and immune system pathways involved in autoinflammatory diseases assisting the reader in understanding the genes and mechanisms involved in these diseases

    Contains chapters focused on sub-specialities of the immune system as well as treatments and sequels common to many autoinflammatory diseases

    Provides the reader with an in depth understanding of the currently available and potential future treatments for autoinflammation


    About this Textbook


    This book, the first complete textbook on this novel field in Medicine, comprehensively covers the clinical presentation, pathogenesis, genetics, and latest management strategies for autoinflammatory disorders as well as the basic science of autoinflammation. Relevant concepts such as how translational science of genetics and immunology relates to the innate immune system and autoinflammation are covered. Descriptions of the monogenic and polygenic/complex diseases that fall under the umbrella of autoinflammatory diseases are provided. Further topics covered include the latest clinical and genetic diagnostic approaches, concepts on the relationship between autoinflammation and autoimmunity/immunodeficiency, the role of autoinflammation in cancer, treatments and management strategies for these diseases, and potential areas of future development.

      The Textbook of Autoinflammation systematically describes and reviews diagnostic and treatment options for autoinflammatory disorders as well as all aspects of the concept of autoinflammation, and represents a valuable resource for professionals in a variety of disciplines who encounter these patients or who study autoinflammation.


    Table of contents (42 chapters)


    Autoinflammation: Past, Present, and Future

    Pages 3-15

    Kastner, Daniel L.

    Genetic Aspects of Investigating and Understanding Autoinflammation

    Pages 19-48

    Ceccherini, Isabella (et al.)

    Epigenetics in Autoinflammation

    Pages 49-60

    Lorente-Sorolla, Clara (et al.)

    Pattern Recognition Receptors in Autoinflammation

    Pages 61-87

    Saavedra, Victor (et al.)

    Inflammasomes and Autoinflammation

    Pages 89-109

    Broderick, Lori

    Cytokines in Autoinflammation

    Pages 111-122

    Rösen-Wolff, Angela (et al.)

    Proteasomes in Autoinflammation

    Pages 123-136

    Brehm, Anja (et al.)

    Disruption of Protein Homeostasis and Activation of Cellular Stress Pathways in Autoinflammation

    Pages 137-147

    Cudrici, Cornelia D. (et al.)

    S100 Proteins in Autoinflammation

    Pages 149-163

    Holzinger, Dirk (et al.)

    Classification of Genetically Defined Autoinflammatory Diseases

    Pages 167-201

    Goldbach-Mansky, Raphaela (et al.)

    Clinical Approach to the Diagnosis of Autoinflammatory Diseases

    Pages 203-223

    Hashkes, Philip J. (et al.)

    Genetic Approach to the Diagnosis of Autoinflammatory Diseases

    Pages 225-237

    Touitou, Isabelle (et al.)

    Monitoring Disease Activity, Damage and Quality of Life

    Pages 239-252

    Haar, Nienke (et al.)

    The Role of International Registries for Rare Autoinflammatory Diseases

    Pages 253-265

    Finetti, Martina (et al.)

    Systemic Amyloidosis

    Pages 267-289

    Rezk, Tamer (et al.)

    Familial Mediterranean Fever

    Pages 293-313

    Padeh, Shai (et al.)

    Mevalonate Kinase Deficiency

    Pages 315-327

    Frenkel, Joost (et al.)

    Tumor Necrosis Factor (TNF) Receptor-Associated Periodic Syndrome (TRAPS)

    Pages 329-345

    Savic, Sinisa (et al.)

    Cryopyrin-Associated Periodic Syndromes (CAPS)

    Pages 347-365

    Hoffman, Hal M. (et al.)

    Autoinflammatory Granulomatous Disease: Blau Syndrome

    Pages 367-381

    Rose, Carlos D. (et al.)

    Very Early Onset Inflammatory Bowel Disease (VEOIBD)

    Pages 383-404

    Muise, Aleixo M.

    Pyogenic Arthritis Pyoderma Gangrenosum and Acne (PAPA) Syndrome

    Pages 405-415

    Punaro, Marilynn G. (et al.)

    Deficiency of Adenosine Deaminase 2 (DADA2)

    Pages 417-431

    Ombrello, Amanda (et al.)

    Genetic Interferonopathies

    Pages 433-453

    Eleftheriou, Despina (et al.)

    Genetic Causes of Inflammatory Bone Disease

    Pages 455-470

    Verbsky, James (et al.)

    Pustular Forms of Psoriasis Related to Autoinflammation

    Pages 471-484

    Mahil, Satveer K. (et al.)

    Hydatidiform Moles

    Pages 485-497

    Nguyen, Ngoc Minh Phuong (et al.)

    Monogenic Autoinflammatory Diseases Associated with Immunodeficiency

    Pages 499-514

    Ombrello, Michael J.

    Other Rare Monogenic Autoinflammatory Diseases

    Pages 515-538

    Jéru, Isabelle (et al.)

    Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Syndrome

    Pages 541-561

    Edwards, Kathryn M. (et al.)

    Chronic Non-Bacterial Osteomyelitis

    Pages 563-585

    Hedrich, Christian M. (et al.)

    Systemic Juvenile Idiopathic Arthritis and Adult Onset Still Disease

    Pages 587-616

    Nigrovic, Peter A. (et al.)

    Macrophage Activation Syndrome in Rheumatic Diseases

    Pages 617-633

    Grom, Alexei A. (et al.)

    Gouty Inflammation

    Pages 635-645

    Schlesinger, Naomi (et al.)

    Behçet Disease

    Pages 647-665

    Gül, Ahmet

    Idiopathic Recurrent Pericarditis

    Pages 667-677

    Imazio, Massimo (et al.)

    Schnitzler Syndrome

    Pages 679-689

    Koning, Heleen D. (et al.)

    Autoinflammation and Autoimmunity

    Pages 693-710

    McGonagle, Dennis (et al.)

    Interleukin-1 Mediated Autoinflammation from Heart Disease to Cancer

    Pages 711-725

    Dinarello, Charles A.


    Pages 729-749

    Ben-Chetrit, Eldad

    Interleukin (IL)-1 Blocking Compounds and Their Use in Autoinflammatory Diseases

    Pages 751-774

    Kallinich, Tilmann (et al.)

    Corticosteroid, Other Biologic and Small Molecule Therapies in Systemic Autoinflammatory Disorders

    Pages 775-791

    Lachmann, Helen J.



  • Textbook of Pediatric Rheumatology, 7e
    La comanda in aproximativ 4 saptamani
    97000lei 800.00 lei



    Matchless in reputation, content, and usefulness, Textbook of Pediatric Rheumatology, 7th Edition, is a must-have for any physician caring for children with rheumatic diseases. It provides an up-to-date, global perspective on every aspect of pediatric rheumatology, reflecting the changes in diagnosis, monitoring, and management that recent advances have made possible ? all enhanced by a full-color design that facilitates a thorough understanding of the science that underlies rheumatic disease.

    "The most comprehensive Pediatric Rheumatology textbook." Reviewed by The Egyptian Rheumatologist, Sep 2015


    Get an authoritative, balanced view of the field with a comprehensive and coherent review of both basic science and clinical practice.

    Apply the knowledge and experience of a who’s who of international experts in the field.

    Examine the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents, including the presentation, differential diagnosis, course, management, and prognosis of every major condition.

    Diagnose and treat effectively through exhaustive reviews of the complex symptoms and signs and lab abnormalities that characterize these clinical disorders.

    New To This Edition:

    Keep current with the latest information on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies.

    Increase your knowledge with three all-new chapters on laboratory investigations, CNS vasculitis, and other vasculitides.

    Understand the evolving globalization of pediatric rheumatology, especially as it is reflected in the diagnosis and management of childhood rheumatic diseases in the southern hemisphere.

    Choose treatment protocols based on the best scientific evidence available today.

    Table Of Contents:


    1 Pediatric Rheumatology: The Study of Rheumatic Diseases in Childhood and Adolescence

    2 Structure and Function

    3 Inflammation and Its Mediators

    4 Adaptive Immunity and Autoimmunity: Translation from Bench to Bedside

    5 Integrative Genomics

    6 Trial Design, Measurement, and Analysis of Clinical Investigations

    7 Assessment of Health Status, Function, and Quality of Life Outcomes

    8 Pain and Its Assessment

    9 Imaging in Pediatric Rheumatic Diseases

    10 Laboratory Investigations

    11 Managing Children with Rheumatic Diseases

    12 Pharmacology and Drug Therapy: Nonbiologic Therapies

    13 Pharmacology: Biologics

    14 Occupational and Physical Therapy for Children with Rheumatic Diseases


    15 Juvenile Idiopathic Arthritis

    16 Systemic Juvenile Idiopathic Arthritis

    17 Polyarticular Juvenile Idiopathic Arthritis

    18 Oligoarticular Juvenile Idiopathic Arthritis

    19 Enthesitis Related Arthritis

    20 Juvenile Psoriatic Arthritis

    21 Arthropathies of Inflammatory Bowel Disease

    22 Uveitis in Juvenile Idiopathic Arthritis


    23 Systemic Lupus Erythematosus

    24 Antiphospholipid Syndrome

    25 Neonatal Lupus Erythematosus

    26 Juvenile Dermatomyositis

    27 Systemic Sclerodermas

    28 Localized Scleroderma

    29 Mixed Connective Tissue Disease and Undifferentiated Connective Tissue Disease

    30 Sjögren Syndrome

    31 Raynaud Phenomenon and Vasomotor Syndromes


    32 Vasculitis and Its Classification

    33 Leukocytoclastic Vasculitis: Henoch–Schönlein Purpura and Hypersensitivity Vasculitis

    34 Polyarteritis Nodosa

    35 Kawasaki Disease

    36 Antineutrophil Cytoplasmic Antibody Associated Vasculitis

    37 Central Nervous System Vasculitis

    38 Other Vasculitis

    39 Pediatric Sarcoidosis

    40 Behçet Disease


    41 Infectious Arthritis and Osteomyelitis

    42 Lyme Disease

    43 Reactive Arthritis

    44 Acute Rheumatic Fever and Poststreptococcal Reactive Arthritis

    45 Musculoskeletal Manifestations of Systemic Disease

    46 Immunodeficiencies and the Rheumatic Diseases

    47 Periodic Fever Syndromes and Other Inherited Autoinflammatory Diseases

    48 Autoinflammatory Bone Disorders

    49 Macrophage Activation Syndrome

    50 Skeletal Malignancies and Related Disorders


    51 Noninflammatory Musculoskeletal Pain

    52 Pain Amplification Syndromes

    53 The Impact of Rheumatic Diseases and Their Treatment on Bone Strength Development in


    54 Primary Disorders of Connective Tissue



  • 1060.00 lei





    Offering up-to-date, comprehensive coverage of disease progression, diagnosis, management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference in the field. For physicians caring for children with rheumatic diseases, this revised 8th Edition is an unparalleled resource for the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents. Global leaders in the field provide reliable, evidence-based guidance, highlighted by superb full-color illustrations that facilitate a thorough understanding of the science that underlies rheumatic disease.

  • 1,38600lei 1200.00 lei

    Confer with leading surgeons on the most effective way to solve complex surgical problems.

    •             110+ pioneering surgeons share tips, pearls, and strategies

    •             Step-by-step guidance for 65+ challenging techniques

    •             600+ illustrations demonstrate crucial details

    Developed in collaboration with the American Orthopaedic Foot and Ankle Society (AOFAS), this techniques-oriented resource puts the expertise and wisdom of top surgeons at your fingertips.


    Sections include:

    •             Conditions of the Hallux

    •             Conditions of the Lesser Toes

    •             Adult-Acquired Flatfoot Deformity

    •             Degenerative Conditions of the Ankle

    •             Amputations

    •             Sports-Related Conditions

    •             Diabetic Conditions

    •             Trauma

    •             Neurologic Disorders

    Techniques chapters are clearly organized for efficient pre-surgical review:

    •             Indications

    •             Contraindications

    •             Alternative Treatments

    •             Results

    •             Techniques

    •             Setup and exposure

    •             Instruments / equipment / implants required

    •             Procedure

    •             Wound Closure

    •             Postoperative Regimen

    •             Avoiding Pitfalls and Complications

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    •             Read directly on your preferred device(s), such as computer, tablet, or smartphone

    •             Easily convert to audiobook, powering your content with natural language text-to-speech

  • 1,99500lei 1605.00 lei




    Through 10 outstanding editions, Kelley & Firestein’s Textbook of Rheumatology has provided authoritative, in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. The 11th Edition of this classic text continues this tradition of excellence, while keeping you abreast of recent advances in genetics and the microbiome, new therapies such as biologics and biosimilars, and other rapid changes in the field. It provides comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, in a user-friendly, full color reference.

    Key Features:

    Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes—including key data on therapeutic outcomes to better inform clinical decision making.

    Includes new chapters on Innate Lymphoid Cells and Natural Killer Cells, Pathogenesis of Inflammasome Mediated Diseases, Bisphosphonates, Ultrasound Evaluation of the Musculoskeletal System, and Evaluation of Monoarticular and Polyarticular Arthritis.

    Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs.

    Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editor Dr. Gary Koretzky, specialist in immunology and rheumatology.

    Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints.

    Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

    Table Of Contents:


    Part 1: Structure and Function of Bone, Joints, and Connective Tissue

    1. Biology of the Normal Joint, 1
    Carla R. Scanzello and Steven R. Goldring

    2. Synovium, 20
    Douglas J. Veale and Gary S. Firestein

    3. Cartilage and Chondrocytes, 34
    Ali Mobasheri, Mary B. Goldring, and Richard F. Loeser

    4. Biology, Physiology, and Morphology of Bone, 60
    Aline Bozec, Anika Grüneboom, and Georg Schett

    5. Muscle: Anatomy, Physiology, and Biochemistry, 67
    Mark S. Miller, Edward P. Debold, and Michael J. Toth

    6. Biomechanics, 80
    Kenton R. Kaufman and KaiNan An

    7. Regenerative Medicine and Tissue Engineering, 92
    Frank P. Luyten, Cosimo De Bari, and Francesco Dell’Accio

    8. Proteinases and Matrix Degradation, 109
    Yoshifumi Itoh

    Part 2: Cells Involved in Autoimmune Diseases and Inflammation

    9. Dendritic Cells, 132
    Mansi Saxena, Nicolas Vabret, Luciana Ribeiro Muniz, and Nina Bhardwaj

    10. Mononuclear Phagocytes, 149
    Deborah R. Winter, Anna Montgomery, and Harris Perlman

    11. Neutrophils, 161
    Binita Shah, Nathalie Burg, and Michael H. Pillinger

    12. T Lymphocytes, 182
    Ralph C. Budd

    13. B Cells, 199
    Yong-Rui Zou, Christine Grimaldi, and Betty Diamond

    14. Fibroblasts and Fibroblast-like Synoviocytes, 222
    Christopher D. Buckley and Andrew Filer

    15. Mast Cells, 241
    Peter A. Nigrovic

    16. Innate Lymphoid Cells and Natural Killer Cells, 254
    Michael A. Paley and Wayne M. Yokoyama

    17. Platelets and Megakaryocytes, 262
    Eric Boilard and Peter A. Nigrovic

    Part 3: Effector Mechanisms in Autoimmunity and Inflammation

    18. Principles of Signaling, 273
    Abel Suarez-Fueyo, Vaishali R. Moulton, and George C. Tsokos

    19. The Immunologic Repercussions of Cell Death, 286
    Helen M. Beere and Douglas R. Green

    20. Innate Immunity, 306
    Gregoire Lauvau and Steven A. Porcelli

    21. Adaptive Immunity, 320
    Martha S. Jordan and Gary A. Koretzky

    22. Autoimmunity and Tolerance, 337
    Dwight H. Kono and Argyrios N. Theofilopoulos

    23. The Microbiome in Health and Disease, 355
    Rob Knight

    24. Metabolic Regulation of Immunity, 368
    Ruoning Wang, Tingting Wang, and Stephen Tait

    25. Genetics of Rheumatic Diseases, 378
    Stephen Eyre and Anne Barton

    26. Epigenetics of Rheumatic Diseases, 393
    Amr H. Sawalha and Matlock A. Jeffries

    27. Complement System, 409
    V. Michael Holers and Leendert A. Trouw

    28. Prostaglandins, Leukotrienes, and Related Compounds, 420
    Robert B. Zurier

    29. Chemokines and Cellular Recruitment, 437
    Gerard Graham

    30. Angiogenesis, 445
    Ursula Fearon, Zoltán Szekanecz, and Douglas J. Veale

    31. Cytokines, 455
    Iain B. McInnes

    32. Experimental Models for Rheumatoid Arthritis, 467
    Rikard Holmdahl

    33. Neuronal Regulation of Pain and Inflammation, 480
    Camilla I. Svensson and Linda S. Sorkin

    Part 4: Broad Issues in the Approach to Rheumatic Disease

    34. Clinical Research Methods in Rheumatic Disease, 495
    Jeffrey R. Curtis, Yvonne M. Golightly, and Kenneth G. Saag

    35. Economic Impact of Arthritis and Rheumatic Conditions, 510
    Louise B. Murphy

    36. Assessment of Health Outcomes, 522
    Dorcas E. Beaton, Maarten Boers, Peter Tugwell, and Lara Maxwell

    37. Biomarkers in Rheumatology, 536
    Michael J. Townsend, Saloumeh K. Fischer, and Andrew C. Chan

    38. Occupational and Recreational Musculoskeletal Disorders, 551
    Richard S. Panush

    39. Cardiovascular Risk in Inflammatory Rheumatic Disease, 563
    Cynthia S. Crowson, Sherine E. Gabriel, and Anne Grete Semb

    40. Cancer Risk in Rheumatic Diseases, 579
    Eric L. Matteson

    41. Introduction to Physical Medicine and Rehabilitation, 592
    Sara J. Cuccurullo, Jaclyn Joki, and Ofure Luke

    42. Pregnancy and Rheumatic Diseases, 604
    Lisa R. Sammaritano and Bonnie L. Bermas

    Part 5: Evaluation of Generalized and Localized Symptoms

    43. History and Physical Examination of the Musculoskeletal System, 621
    John M. Davis III, Kevin G. Moder, and Gene G. Hunder

    44. Ultrasound in Rheumatology, 638
    Eugene Y. Kissin, Paul J. DeMarco, and Amy C. Cannella

    45. Evaluation of Monoarticular and Polyarticular Arthritis, 663
    Ronald F. van Vollenhoven

    46. Skin and Rheumatic Diseases, 678
    David F. Fiorentino and Victoria P. Werth

    47. The Eye and Rheumatic Diseases, 702
    James T. Rosenbaum

    Part 6: Differential Diagnosis of Regional and Diffuse Musculoskeletal  Pain

    48. Neck Pain, 711
    Jennifer Kosty, Rani Nasser, Raul A. Vasquez, Cyrus C. Wong, and Joseph S. Cheng

    49. Shoulder Pain, 727
    Scott David Martin and Thomas S. Thornhill

    50. Low Back Pain, 753
    Rajiv Dixit

    51. Hip and Knee Pain, 776
    James I. Huddleston, III, and Stuart Goodman

    52. Foot and Ankle Pain, 792
    Christopher P. Chiodo, Mark D. Price, and Adam P. Sangeorzan

    53. Hand and Wrist Pain, 800
    Kenneth W. Donohue, Felicity G. Fishman, and Carrie R. Swigart

    54. Temporomandibular Joint Pain, 813
    Daniel M. Laskin

    55. Fibromyalgia, 825
    Leslie J. Crofford

    Part 7: Diagnostic Tests and Procedures in Rheumatic Diseases

    56. Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology, 841
    Hani S. El-Gabalawy and Stacy Tanner

    57. Arthrocentesis and Injection of Joints and Soft Tissues, 859
    Ahmed S. Zayat, Andrea di Matteo, and Richard J. Wakefield

    58. Anti-nuclear Antibodies, 875
    Stanford L. Peng and Joseph E. Craft

    59. Autoantibodies in Rheumatoid Arthritis, 890
    Erika Darrah, Antony Rosen, and Felipe Andrade

    60. Acute Phase Reactants, 907
    Rebecca Haberman, Cesar E. Fors Nieves, Bruce N. Cronstein, and Amit Saxena

    61.Imaging in Rheumatic  Diseases,  920
    Mikkel Østergaard, Ho Jen, Jacob L. Jaremko, and Robert G.W. Lambert

    Part 8:  Pharmacology of Anti-rheumatic Drugs

    62. Therapeutic Targeting of Prostanoids, 965
    Leslie J. Crofford

    63. Glucocorticoid Therapy, 985
    Marlies C. van der Goes and Johannes W.G. Jacobs

    64. Traditional DMARDs: Methotrexate, Lefl, Sulfasalazine, Hydroxychloroquine, and Combination Therapies, 1007
    Amy C. Cannella and James R. O’Dell

    65. Immunosuppressive Drugs, 1031
    Jacob M. van Laar

    66. Anti-cytokine Therapies,   1046
    Katharine McCarthy, Arthur Kavanaugh, and Christopher T. Ritchlin

    67. Cell-Targeted Biologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics, 1068
    Peter C. Taylor

    68. Intra-cellular Targeting Agents in Rheumatic Disease, 1091
    Virginia Reddy and Stanley Cohen

    69. Urate-Lowering Therapy, 1111
    Ted R. Mikuls

    70. Bisphosphonates, 1125
    Arthur C. Santora II and Kenneth G. Saag

    71. Analgesic Agents in Rheumatic Disease, 1135
    Gregory R. Polston and Mark S. Wallace

    72. Nutrition and Rheumatic Diseases, 1156
    Lisa K. Stamp and Leslie G. Cleland

    73. Evaluation and Management of Early Undifferentiated Arthritis, 1173
    Karim Raza


    Part 9:  Rheumatoid Arthritis

    74. Etiology of Rheumatoid Arthritis, 1181
    Gary S. Firestein

    75. Pathogenesis of Rheumatoid Arthritis, 1200
    Gary S. Firestein

    76. Clinical Features of Rheumatoid Arthritis, 1236
    Bryant R. England and Ted R. Mikuls

    77. Treatment of Rheumatoid Arthritis, 1258
    James R. O’Dell

    78. Sjögren’s Syndrome, 1284
    E. William St. Clair and David L. Leverenz

    Part 10: Spondyloarthritis

    79. Etiology and Pathogenesis of Spondyloarthritis, 1307
    Keith A. Sikora and Robert A. Colbert

    80. Ankylosing Spondylitis and Other Forms of Axial Spondyloarthritis,  1319
    Sjef van der Linden, Matthew Brown, Lianne S. Gensler, Tony Kenna, Walter P. Maksymowych, and William J. Taylor

    81. Reactive Arthritis, 1344
    John D. Carter and Alan P. Hudson

    82. Psoriatic Arthritis, 1359
    Oliver FitzGerald and Conor Magee

    83. Inflammatory Bowel Disease-Associated Arthritis and Other Enteropathic Arthropathies, 1381
    Richard Zamore, Meenakshi Bewtra, and Alexis Ogdie

    Part 11: Systemic Lupus Erythematosus and Related Syndromes

    84. Etiology and Pathogenesis of Systemic Lupus Erythematosus, 1396
    Mary K. Crow

    85. Clinical Features of Systemic Lupus Erythematosus, 1413
    Maria Dall’Era and David Wofsy

    86. Treatment of Systemic Lupus Erythematosus, 1437
    Antonis Fanouriakis, George Bertsias, and Dimitrios T. Boumpas

    87. Antiphospholipid Syndrome, 1460
    Medha Barbhaiya, Jane E. Salmon, and Doruk Erkan

    Part 12: Systemic Sclerosis, Inflammatory Myopathies, and Overlap Syndromes

    88. Etiology and Pathogenesis of Systemic Sclerosis, 1473
    John Varga

    89. Clinical Features and Treatment of Scleroderma, 1499
    Fredrick M. Wigley and Francesco Boin

    90. Inflammatory Diseases of Muscle and Other Myopathies, 1539
    Kanneboyina Nagaraju, Rohit Aggarwal, and Ingrid E. Lundberg

    91. Overlap Syndromes, 1569
    Jonathan Graf

    Part 13:  Vasculitis

    92. Classification and Epidemiology of Systemic Vasculitis, 1584
    Rennie L. Rhee and Peter A. Merkel

    93. Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu’s Arteritis, 1595
    David B. Hellmann

    94. Anti-neutrophil Cytoplasmic Antibody- Associated Vasculitis, 1617
    Sharon A. Chung and Paul A. Monach

    95. Polyarteritis Nodosa and Related Disorders, 1634
    Raashid Luqmani and Abid Awisat

    96. Immune Complex-Mediated Small Vessel Vasculitis, 1649
    John H. Stone

    97. Primary Angiitis of the Central Nervous System, 1659
    Rula A. Hajj-Ali and Carol A. Langford

    98. Behçet’s Disease, 1666
    Christine S. Ahn, Lindsay C. Strowd, and Joseph L. Jorizzo

    Part 14: Crystal-Induced and Inflammasome- Mediated Inflammation

    99. Pathogenesis of Inflammasome-Mediated Diseases, 1676
    Hal M. Hoffman and Lori Broderick

    100. Etiology and Pathogenesis of Hyperuricemia and Gout, 1687
    Robert T. Keenan, Michael Toprover, and Michael H. Pillinger

    101. Clinical Features and Treatment of Gout, 1710
    Nicola Dalbeth

    102. Calcium Crystal Disease: Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate, 1732
    Robert Terkeltaub

    103. Familial Autoinflammatory Syndromes, 1752
    Catharina M. Mulders-Manders, Anna Simon, and Jos W.M. van der Meer

    Part 15: Cartilage, Bone, and Heritable Connective Tissue Disorders

    104. Pathogenesis of Osteoarthritis, 1770
    Paul E. Di Cesare, Dominik R. Haudenschild, Steven B. Abramson, and Jonathan Samuels

    105. Clinical Features of Osteoarthritis, 1789
    Amanda E. Nelson

    106. Treatment of Osteoarthritis, 1803
    Devyani Misra, Deepak Kumar, and Tuhina Neogi

    107. Metabolic Bone Disease, 1819
    Nancy E. Lane

    108. Proliferative Bone Diseases, 1839
    Reuven Mader

    109. Osteonecrosis, 1852
    Christopher Chang, Adam Greenspan, and M. Eric Gershwin

    110. Relapsing Polychondritis, 1876
    Gaye Cunnane

    111. Heritable Diseases of Connective Tissue, 1886
    Deborah Krakow

    Part 16: Rheumatic Diseases of Childhood

    112. Etiology and Pathogenesis of Juvenile Idiopathic Arthritis, 1905
    Edward M. Behrens

    113. Clinical Features and Treatment of Juvenile Idiopathic Arthritis, 1911
    Joyce J. Hsu, Tzielan C. Lee, and Christy I. Sandborg

    114. Childhood-Onset Systemic Lupus Erythematosus, Drug-Induced Lupus in Children, and Neonatal Lupus, 1931
    Stacy P. Ardoin and Fatima Barbar-Smiley

    115.Juvenile Dermatomyositis, Scleroderma, Vasculitis, and Autoimmune Brain Disease,  1942
    Angela B. Robinson, Jeffrey Dvergsten, Kathryn S. Torok, Heather Van Mater, William Gallentine, and Ann M. Reed

    Part 17: Infection and Arthritis

    116. Bacterial Arthritis, 1979
    Paul P. Cook and Dawd S. Siraj

    117. Lyme Disease, 1994
    Linda K. Bockenstedt

    118. Mycobacterial Infections of Bones and Joints, 2009
    Eric M. Ruderman and John P. Flaherty

    119. Fungal Infections of Bones and Joints, 2022
    Eric M. Ruderman and John P. Flaherty

    120. Rheumatic Manifestations of HIV Infection, 2033
    Jonathan Dau and John D. Reveille

    121. Viral Arthritis, 2048
    Philippe Gasque and Xavier Guillot

    122. Rheumatic Fever and Post-streptococcal Arthritis, 2061
    Luiza Guilherme, Pedro Ming Azevedo, and Jorge Kalil

    Part 18: Arthritis Accompanying Systemic Disease

    123. Amyloidosis, 2077
    Helen J. Lachmann and Faye A. Sharpley

    124. Sarcoidosis, 2088
    Peter Korsten, Nadera J. Sweiss, and Robert P. Baughman

    125. Hemochromatosis, 2105
    Gaye Cunnane

    126. Hemophilic Arthropathy, 2115
    Astrid E. Pulles, Lize F. D. van Vulpen, and Floris P.J.G. Lafeber

    127. Rheumatic Manifestations of Hemoglobinopathies,  2127
    Carlos J. Lozada and Elaine C. Tozman

    128. IgG4-Related Disease, 2135
    John H. Stone and Shiv Pillai

    129. Arthritis Accompanying Endocrine and Metabolic Disorders, 2149
    Sebastian E. Sattui and Joseph A. Markenson

    130. Rheumatic  Paraneoplastic  Syndromes-Links Between Malignancy and Autoimmunity, 2161
    Bernhard Manger and Georg Schett

    131. Tumors and Tumor-like Lesions of Joints and Related Structures, 2167
    Darcy A. Kerr and Andrew E. Rosenberg

    132. Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer, 2189
    Laura C. Cappelli, Clifton O. Bingham III, and Ami A. Shah

    Index, I-1




  • 2,13100lei 1740.00 lei



    Thoroughly revised and updated, the 7th Edition of Rheumatology remains a leading text in this fast-changing field, keeping you abreast of recent advances in medications, therapies, clinical trials, and much more. Dr. Mark Hochberg and his team of expert authors and editors cover everything you need to know -- from basic scientific principles to practical clinical management strategies, all in a user-friendly, accessible manner.


    Provides access to quick, concise videos depicting musculoskeletal ultrasound including anisotropy, "comet tail" needle artifact, rheumatoid arthritis synovitis, acute gout, and more.

    Uses a consistent, logical, reader-friendly format with templated content and large-scale images for efficient visual reference.

    New To This Edition:

    Features 14 completely new chapters covering biomedical and translational science, disease and outcome assessment, including new imaging modalities and early emerging disease, clinical therapeutics, and patient management and rehabilitation.

    Includes updated content on the latest diagnostic perspectives and approaches to therapy including tapering down of treatment, pulmonary hypertension and scleroderma, psoriatic arthritis, and the latest oral anticoagulants.

    Covers hot topics such as pathogenesis and pathophysiology of axial spondyloarthritis, DXA and measurement of bone, infectious arthritis, and more.

    Shares the knowledge and expertise of internationally recognized rheumatoid arthritis expert and new editor, Dr. Ellen Gravallese.

    Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.


  • 1,98500lei 1750.00 lei



    Consult the definitive resource in rheumatology for an in-depth understanding of scientific advances as they apply to clinical practice. Masterfully edited by Drs. Gary S. Firestein, Ralph C. Budd, Sherine E. Gabriel, Iain B. McInnes, and James R. O'Dell, and authored by internationally renowned scientists and clinicians in the field, Kelley and Firestein’s Textbook of Rheumatology, 10th Edition, delivers the knowledge you need for accurate diagnoses and effective patient care. From basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes, this state-of-the-art reference provides a global, authoritative perspective on the manifestations, diagnosis and treatment of rheumatic diseases.


    An ideal balance of the basic science you need to know and how to apply that information to clinical practice.

    An integrated chapter format allows you to review basic science advances and their clinical implications in one place and get dependable, evidence-based guidance for the full range of rheumatologic diseases and syndromes.

    Videos online demonstrate the complete musculoskeletal exam, including abnormal findings and the arthroscopic presentation of diseased joints.

    New To This Edition:

    New content on the latest diagnostic perspectives and approaches to therapy, including five brand-new chapters: Metabolic Regulation of Immunity, Principles of Signaling, Research Methods in the Rheumatic Diseases, Novel Intracellular Targeting Agents, and IgG4-Related Diseases.

    New and expanded chapter topics on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies.

    More schematic diagrams clearly summarize information and facilitate understanding.

    Table Of Contents:

    1 Biology of the Normal Joint

    2 Synovium

    3 Cartilage and Chondrocytes

    4 Biology, Physiology, and Morphology of Bone

    5 Muscle: Anatomy, Physiology, and Biochemistry

    6 Biomechanics

    7 Tissue Engineering

    8 Proteinases and Matrix Degradation

    9 Dendritic Cells


    11 Neutrophils

    12 T Lymphocytes

    13 B Cells

    14 Fibroblasts and Fibroblast-like Synoviocytes

    15 Mast Cells

    16 Platelets and Rheumatic Diseases

    17 Innate Immunity

    18 ADAPTIVE IMMUNITY and Organization of Lymphoid Tissues

    19 Autoimmunity


    21 Genetics of Rheumatic Diseases

    22 Epigenetics of rheumatic diseases

    23 Complement System

    24 Prostaglandins, Leukotrienes, and Related Compounds

    25 Cell Recruitment and Angiogenesis

    26 Cytokines


    28 Cell Survival and Death in Rheumatic Diseases

    29 Animal Models of Rheumatic Diseases

    30 Neural regulation of Pain and Inflammation



    33 Assessment of Health Outcomes IN RHEUMATIC DISEASES

    34 Biologic Markers

    35 Occupational and Recreational MSK Disorders

    36 Cardiovascular Risk in Rheumatic Disease

    37 Cancer Risk in Rheumatic Diseases

    38 Introduction to Physical Medicine, Physical Therapy and Rehabilitation

    39 Pregnancy and Rheumatic Diseases

    40 History and Physical Examination of the Musculoskeletal System



    43 The Skin and Rheumatic Diseases

    44 The Eye and Rheumatic Diseases

    45 Neck Pain

    46 Shoulder Pain

    47 Low Back Pain

    48 Hip and Knee Pain

    49 Ankle and Foot Pain

    50 Hand and Wrist Pain

    51 Temporomandibular Joint Pain

    52 Fibromyalgia

    53 Synovial Fluid Analysis, Synovial Biopsy, and Synovial Pathology

    54 Arthrocentesis and Injection of Joints and Soft Tissue

    55 Antinuclear Antibodies

    56 Autoantibodies in rheumatoid arthritis

    57 Acute Phase Reactants

    58 Imaging Modalities in Rheumatic Disease

    59 Prostanoid Biology and its Therapeutic Targeting

    60 Glucocorticoid Therapy

    61 Traditional DMARDS: Methotrexate, Leflunomide, Sulfasalazine, and Hydroxychloroquine and Combination Therapies

    62 TRADITIONAL Immunoregulatory Drugs

    63 Anticytokine Therapies

    64 Cell Targeted Biologics


    66 Urate Lowering Therapy

    67 Analgesic Agents in Rheumatic Diseases

    68 Nutrition and Rheumatic Disease

    69 Etiology and Pathogenesis of Rheumatoid Arthritis

    70 Clinical Features of Rheumatoid Arthriti

    71 Treatment of Rheumatoid Arthritis

    72 Early Synovitis and Early Undifferentiated Arthritis

    73 Sjogren's Syndrome

    74 Etiology and Pathogenesis of Spondyloarthropathies

    75 Ankylosing Spondylitis

    76 Undifferentiated Spondyloarthritis and Reactive Arthritis

    77 Psoriatic Arthritis

    78 Enteropathic Arthritis

    79 Etiology and Pathogenesis of SLE

    80 Clinical Features of SLE

    81 Treatment of SLE

    82 Antiphospholipid Syndrome

    83 Etiology and Pathogenesis of Scleroderma

    84 Clinical Features and Treatment of Scleroderma

    85 Inflammatory Diseases of Muscle and Other Myopathies

    86 Overlap Syndromes

    87 Classification and Epidemiology of Systemic Vasculitis

    88 Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu's Arteritis

    89 Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

    90 Polyarteritis and Related Disorders

    91 Immune Complex-Mediated Small Vessel Vasculitis

    92 Isolated Angiitis of the Nervous System

    93 Bechet's Disease

    94 Etiology and Pathogenesis of Gout and Hyperuricemia

    95 Clinical Features and Treatment of Gout

    96 Calcium Crystal Diseases: Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate

    97 Familial Autoinflammatory Syndromes

    98 Etiology and Pathogenesis of Osteoarthritis

    99 Clinical Features of Osteoarthritis

    100 Treatment of Osteoarthritis

    101 Metabolic Bone Disease

    102 Proliferative Bone Disease

    103 Osteonecrosis

    104 Relapsing Polychondritis

    105 Heritable Diseases of Connective Tissue

    106 Etiology and Pathogenesis of Juvenile Idiopathic Arthritis

    107 Treatment of Juvenile Inflammatory Arthritis

    108 SLE, Juvenile Dermatomyositis, Scleroderma and Vasculitis

    109 Bacterial Arthritis

    110 Lyme Disease

    111 Mycobacterial Infections of Bones and Joints

    112 Fungal Infections of Bones and Joints

    113 Rheumatic Manifestations of HIV Infection

    114 Viral Arthritis

    115 Rheumatic Fever and Post-Streptococcal Arthritis

    116 Amyloidosis

    117 Sarcoidosis

    118 Hemachromotosis

    119 Hemophilic Arthropathy

    120 Rheumatic Manifestations of Hemoglobinopathies


    122 Arthritis Accompanying Endocrine and Metabolic Disorders

    123 Musculoskeletal Syndromes Associated with Malignancy

    124 Tumors and Tumor-like Lesions of Joints and Related Structures