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  • Ebola: An Evolving Story
    La comanda in aproximativ 4 saptamani
    120.00 lei

    The book is a narrative of the unfolding of the Ebola virus disease outbreak from a scientific view point. The author provides an analysis of the scientific basis of public health policies that have influenced the public's, and the medical community's, abilities to understand the virus and the disease. This is done in the context of providing insights into the biology of the virus, and exploring open questions, including its likely modes of transmission. The author has included citations from the scientific literature and the press, as well as quotes from expert interviews. The book will help sort out the fact from fiction, given the confusion that arose after the virus arrived in the US. The author used his objective research skills and knowledge of evolutionary genetics and molecular biology to find out what was known, and what questions remained unanswered, and even what questions remained unasked.Written in an accessible style, it is intended for the educated general public, scientists, policy makers, health care workers, and politicians. It delves into the problems of trying to derive a logic-based understanding of a highly lethal emerging disease in 2014, when research funding cuts have gutted research institutions, and when public health institutions really were woefully unprepared. It is a highly distinct narrative analysis that is sure to stimulate new research and thinking in public policy. It will inform thousands of people of the nature of the virus, how it works, in terms they are likely to be able to understand. It will allow others to rapidly catch up with the story of Ebola.

  • 13400lei 130.00 lei

    First published in 1903, this book presents a wide-ranging study of rabies. Three key areas of the disease are explored: its causation in the individual organism, its place among germ diseases with the end of bacterial agency in the animal economy, and its origin in the animal kingdom. This book will be of value to anyone with an interest in epidemiology and the historical understanding of rabies.

  • 140.00 lei

    Originally published in 1915, this book gathers together a collection of papers on tuberculosis by the renowned British epidemiologist Arthur Ransome (1834–1922). The papers approach the subject from a number of different viewpoints, encompassing both scientific and public health perspectives, and draw on Ransome's experience of more than fifty years fighting tuberculosis. Illustrative figures and notes are also incorporated within the text. This book will be of value to anyone with an interest in tuberculosis and the history of medicine.

  • Cerebro-Spinal Fever
    La comanda in aproximativ 4 saptamani
    140.00 lei

    In 1915, an outbreak of meningitis affected the Eastern Command in the British Army. Foster and Gaskell, both Captains in the Royal Army Medical Corps in the Territorial Army, were on hand to witness the effect of the disease, and the following year they published this study of the disease's symptoms and treatment as they observed it. The text is accompanied by plates illustrating meningitis' effects on the skin and brain. This book will be of value to anyone with an interest in the history of epidemiology and the treatment of meningitis.

  • 15700lei 140.00 lei

    Nelson's Neonatal Antimicrobial Therapy is your go-to reference for treating neonates with infectious diseases. This handy reference provides evidence-based recommendations from leading experts in antimicrobial therapy for the treatment of infectious diseases in neonates. Get expert advice on: Dosing for neonates, including low-birth-weight newborns Drug selection for bacterial, fungal, viral and parasitic pathogens Drug Stewardship And more

  • Clinical Epidemiology
    La comanda in aproximativ 4 saptamani
    20000lei 170.00 lei


    Now in its Sixth Edition, Clinical Epidemiology: The Essentials is a comprehensive, concise, and clinically oriented introduction to the subject of epidemiology. Written by expert educators, this approachable, informative text introduces students to the principles of evidence-based medicine that will help them develop and apply methods of clinical observation in order to form accurate conclusions.  

    The updated Sixth Edition reflects the most current approaches to clinical epidemiology, including the latest coverage of modeling and expanded insight on applying concepts to clinical practice, with updated, clinical vignette-style end-of-chapter questions to help strengthen students understanding and ensure a confident transition to clinical settings. Updated content throughout reflects the latest practices in clinical epidemiology. Increased emphasis on clinical judgment helps students confidently evaluate the effectiveness of guidelines and integrate them into practice. Updated vignette-style end-of-chapter questions place concepts in a clinical context and reinforce students understanding. Key Word Lists at the start of each chapter familiarize students with critical terminology for clinical competence. Example boxes clarify the clinical implications of important concepts with relevant real-world patient care scenarios. Appendix of Additional Readings highlights trusted resources for further review. eBook available for purchase. Fast, smart, and convenient, today s eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and more.

  • 170.00 lei

    Originally published in 1917, as part of the Cambridge Public Health Series, this book was written to provide a guide for those 'interested in the stamping out of tuberculosis'. The text approaches the disease from an outlook based around experimental pathology, avoiding the clinical perspective already well represented in previous works by other researchers. Numerous illustrative figures and an appendices section are also included. This book will be of value to anyone with an interest in public health, the history of medicine and the historical understanding of tuberculosis.

  • 180.00 lei

    In this first volume of his history of epidemics in Britain, controversial physician Charles Creighton begins his examination of diseases in Britain from the first British epidemic in 664 AD to the end of the Great Plague in 1666. The work is broken down by time period and disease, ranging from Bede's record of the plague of 664–684 to 'the French pox', as well as outbreaks during sea voyages and in the early colonies. This work will be of value to medical historians and those with an interest in epidemiology.

  • 19600lei 185.00 lei

    Provides a detailed, evidence-based overview of a range of topics necessary for understanding infectious diseases. It is primarily aimed to offer important background on regional disease epidemiology, pathogenesis, social, and ethical aspects of disease control through the use of specific antimicrobial agents and preventive vaccines. Different aspects of infectious disease are addressed and each chapter begins with an annotation of key terms, and definitions and finishes with a concrete summary, using bullet points. The excellent tables and illustrative figures in each chapter are presented with useful proactive diagnostic essentials including nonculture-based molecular advances for early diagnosis and appropriate management. Thirty different chapters are dealt from subject matters on antibiotic uses, vaccine prevention strategies for all ages, and disease transmission control in hospital care environments. The second edition provides wealth of timely information and up-to-date overview of the commonly encountering infectious diseases in the clinical practice. Includes material on the most important newly emerging and re-emerging diseases. Each chapter is amply illustrated with photographs and figures provide unparalleled visual guidance. Contains reference tables with differential diagnoses, laboratory diagnoses and treatment aspects. Valuable appendices provide cross reference information for each of the bacterial, viral, fungal, and parasitic diseases.

  • 185.00 lei

    In this second volume of his history of epidemics in Britain, controversial physician Charles Creighton continues his examination of diseases in Britain from the time of Charles II to the time of the volume's publication in 1894. The work is broken down by disease, ranging from typhus to childhood diseases, as well as examining the origin and consequences of specific outbreaks in the United Kingdom, Ireland and among British troops abroad. This work will be of value to medical historians and those with an interest in epidemiology.

  • 21400lei 185.00 lei

    Fully reviewed and revised for its second edition, the Oxford Handbook of Infectious Diseases and Microbiology maintains its position as the must-have guide to all aspects of infectious diseases and microbiology. Reflecting the current approach to joint postgraduate training programmes, the handbook takes an integrated approach to both subjects. It covers the basic principles of bacteriology and virology, along with specific guidance on individual diseases and conditions, all in the accessible Oxford Handbook style.

    Now including new topics on important subjects such as microbiology specimen collection, commonly used media, molecular diagnostics, and antimicrobials in pregnancy, as well as incorporating new guidelines from WHO, NICE, and BASHH among others, this handbook ensures that the informaiton you need is accessible, clear, and easy-to-understand.

    Practical and comprehensive, this handbook includes coverage of National Frameworks and current legislation, together with information on topical issues such as bioterrorism and preventative medicine. Fully reviewed by specialist senior readers, and with useful links to up-to-date clinical information and online resources, this is an important addition to the Oxford Handbook Series.

  • 22500lei 200.00 lei


    • Concise pocketbook designed to support physicians, virologists, and immunologists in their day-to-day practice
    • Written and edited by key thought leaders and developed using the latest clinical evidence and guidelines
    • High quality full-color supportive illustrations, tables and graphs enable complicated concepts to be made clear to readers with different levels of background understanding

    About this book

    This concise pocketbook will provide readers with an overview and background of meningococcal disease, treatment options and emerging therapies, and methods of prevention. The book was originally commissioned due to recent developments in vaccinations to prevent meningococcal disease.

    This book reviews the disease progression and associated risk factors; its pathogenesis and diagnosis; methods of treatment and prevention, both current and emerging; and the future directions of meningococcal disease management. The book is ideal for busy healthcare professionals, as it covers all aspects of the disease and its treatment in a condensed and manageable format, whilst including the most up-to-date treatment guidelines and algorithms.


    Table of contents (7 chapters)


    ·         Introduction and epidemiology of meningococcal disease

    Trotter, Caroline (et al.)

    Pages 1-14

    ·         Carriage and transmission of

    Trotter, Caroline L. (et al.)

    Pages 15-23

    ·         Pathogenesis of invasive disease

    Øvstebo, Reidun (et al.)

    Pages 25-43

    ·         Diagnosis of meningococcal disease

    Tsang, Raymond (et al.)

    Pages 45-55

    ·         Clinical aspects of meningococcal disease

    Pelton, Stephen (et al.)

    Pages 57-73

    ·         Treatment of meningococcal disease

    Nadel, Simon (et al.)

    Pages 75-90

    ·         Prevention of meningococcal disease through vaccination

    Pollard, Andrew J. (et al.)

    Pages 91-103

  • Evidence-Based Neonatal Infections
    La comanda in aproximativ 4 saptamani
    33100lei 285.00 lei

    Evidence-Based Neonatal Infections is expertly written by David Isaacs, an experienced author renowned for his knowledge in both pediatric infections and evidence-based medicine. It critically analyses the evidence for decision making in neonatal infections. Evidence-Based Neonatal Infections * The first evidence-based text on neonatal infections * Provides practical guidance where evidence is poor * Complements David Isaacs Evidence-Based Pediatric Infectious Diseases (9781405148580) Practical and evidence-based, Evidence-Based Neonatal Infections is designed to help the clinician with day-to-day decisions on the care of newborn babies with possible, probable or proven infections. It considers clinical questions relevant to neonatologists, analysing the evidence carefully and providing recommendations for optimum management of neonatal infectious diseases, whilst reflecting on: * Efficacy and safety * Antibiotic resistance * Cost effectiveness * Adverse effects * Ethical considerations Evidence-Based Neonatal Infections provides a unique reference for neonatologists, pediatricians, trainees, specialist nurses; general practitioners, microbiologists, infection control doctors, and all staff in neonatal units.

  • Asthma and Infections
    La comanda in aproximativ 4 saptamani
    320.00 lei

    An invaluable resource, this book covers the full range of respiratory infections and explores the techniques used to detect the pathogens involved in asthma. Fifteen international experts representing the range of specialties involved in treating asthma examine the relationship between asthma and infection. They provide authoritative, time-tested guidance clinicians and researchers can utilize and trust. They cover bacterial and viral respiratory infections and pathogen detection, examining how microbes, infections, and antibiotic and anti-inflammatory agents affect asthma. The book helps readers identify the basic, translational, clinical aspects of asthma bacterial infection, inflammation, and allergic response. Not only does it present the facts but raises questions that will stimulate the clinical and research communities to explore new avenues that may provide clear answers to old questions.

  • Diagnosis of Fungal Infections
    La comanda in aproximativ 4 saptamani
    350.00 lei

    Analyzing a key cause of infectious morbidity in immunosuppressed and immunocompromised patients, this source spans the most recent strategies to improve and expedite the diagnosis, identification, and treatment of fungal infections.

    With authoritative contributions from experienced clinicians in the field, this reference tracks developments in imaging, susceptibility testing, and strain typing to combat these conditions in transplant, surgical, oncology, and intensive care units.


    Half Title

    Infectious Disease and Therapy

    Title Page

    Copyright Page




      Part I: General Considerations of Diagnostic Methods in Systemic Fungal Infections

      1. Pearls in Establishing a Clinical Diagnosis: Signs and Symptoms

      2. The Role of Conventional Diagnostic Tools

      3. The Role of Radiology in the Diagnosis of Fungal Infections

      4. Serodiagnosis: Antibody and Antigen Detection

      5. Detection of Fungal Metabolites

      6. Molecular Diagnostics: Present and Future

      Part II: Diagnostic Approaches to Specific Fungal Infections

      7. Superficial and Mucosal Fungal Infections

      8. Invasive Mold Infections

      9. Invasive Yeast Infections

      10. Diagnosis of Cryptococcosis

      11. A Diagnostic Approach to Pneumocystis jiroveci Pneumonia

      12. The Diagnosis of Endemic Mycoses

      13. Hypersensitivity and Allergic Fungal Manifestations: Diagnostic Approaches

      Part III: Moving Forward: “Futuristic” Issues

      14. Molecular Mycology and Emerging Fungal Pathogens


    About the Editors

  • 43000lei 350.00 lei

     Transplant and oncology patients present a challenge to the infectious disease specialist because many of the entities that infect them are hard to diagnose.  Chemotherapy may further complicate the situation, since it may contraindicate a biopsy or interfere with antibiotic therapy. This issue of Infectious Disease Clinics provides specific information on several entities with the purpose of helping physicians to best treat these difficult infections.

  • 375.00 lei

    CONGENITAL AND PERINATAL INFECTIONS provides a concise and clinically-oriented primer on the congenital and perinatal infections likely to present in clinical practice. Written with the busy clinician in mind, it combines easy accessibility with state-of-the-art information on the epidemiology, pathogenesis, clinical manifestations, diagnosis, treatment, and prevention of congenital and perinatal infections.

    Eschewing the notion that congenital and perinatal infections only encompass agents from the TORCH group of pathogens, this volume offers comprehensive information on the spectrum of viral, bacterial, and parasitic infections that can manifest in mother or child. Combined with its brevity and emphasis on clinical management, CONGENITAL AND PERINATAL INFECTIONS is a definitive new guide to understanding this challenging group of infections.

  • 44000lei 390.00 lei

    Written by an international team of authors specializing in microbiology and infectious disease, this new edition of Evidenced-based Infectious Diseases presents practical, up-to-date information on the care of individual patients suffering from infectious diseases. Each chapter addresses a series of focused clinical questions addressed in a systematic fashion, including a comprehensive literature search, and a rating of the quality of evidence using principles of the GRADE framework. Evidence-Based Infectious Diseases is the ideal reference work for all those involved with microbiology, infectious diseases, and clinical management. 

    Table of contents

    List of Contributors vii

    Preface xi

    1 Introduction to Evidence‐based Infectious Diseases 1

    Dominik Mertz, Nick Daneman, and Fiona Smaill

    Part 1 Specific Diseases 11

    2 Skin and Soft‐tissue Infections 13

    Douglas Austgarden and Guilio DiDiodato

    3 Bone and Joint Infections 23

    Nora Renz and Andrej Trampuz

    4 Infective Endocarditis 37

    Bahareh Ghadaki and Deborah Yamamura

    5 Meningitis and Encephalitis 53

    Christopher E. Kandel and Wayne L. Gold

    6 Community‐acquired Pneumonia 73

    Mark Downing and Jennie Johnstone

    7 Healthcare‐associated Pneumonia 81

    Jennie Johnstone and Mark Downing

    8 Tuberculosis 87

    Peter Daley and Marek Smieja

    9 Clostridium Difficile Infection in Adults 99

    Louis Valiquette

    10 Urinary Tract Infections 107

    Thomas Fekete

    11 Sexually Transmitted Infections 127

    Courtney A. Thompson, Darrell H. S. Tan, and Kaede Sullivan

    12 Human Immunodeficiency Virus (HIV) 149

    Ali Amini, Monique Andersson, Ravindra Gupta, and Brian Angus

    13 Hepatitis 181

    Lise Bondy and Michael S. Silverman

    14 Influenza 193

    Ashley Roberts and Joanne M. Langley

    15 Critical Care 201

    Bram Rochwerg and Jocelyn A. Srigley

    Part 2 Special Populations 215

    16 Infection Prevention and Control 217

    Graham M. Snyder and Eli N. Perencevich

    17 Antimicrobial Stewardship 235

    Alainna J. Jamal and Andrew M. Morris

    18 Infections in Neutropenic Hosts 251

    Eric J. Bow

    19 Infections in General Surgery 269

    Paul A. Moroz and Christine H. Lee

    20 Infections in Healthcare Workers 279

    Gregory W. Rose

    Index 287

  • 47700lei 400.00 lei

    This book aims to fill knowledge gap among healthcare workers about Clostridium difficile (also known as C.difficile and CDI) among aging patients, especially those in long-term care facilities (LTCFs).  Written by experts in infectious diseases and geriatric medicine, this book provides comprehensive information on all aspects of CDI pertaining to LTCF settings, including epidemiology, diagnosis, prevention, management and the unique challenges faced by LTCFs with regards to the CDI problem.

    The book begins by introducing the topic as it relates to aging patients before delving into the various aspects of CDI management.  Topics include infection control and prevention, treatment of CDI, and the establishment of antibiotic stewardship programs to reduce inappropriate antibiotic use and reduce CDI rates. The book also features a chapter on probiotics for the prevention of CDI and new strategies to monitor environmental cleaning practices of CDI patient rooms that do not appear in any other resource.

    Clostridium Difficile Infection in Long-Term Care Facilities is an excellent resource for geriatricians, infectious diseases specialists, long-term care administrators, nurses, pharmacists, researchers, and all clinicians working with infections in long-term care settings.


    Front Matter

      1. Introduction

      2. Epidemiology of Clostridioides difficile Infection in Long-Term Care Facilities

      3. Role of Asymptomatic Carriers in Long-Term Care Facility Clostridioides (Clostridium) difficile Transmission

      4. Clostridium difficile (Clostridioides difficile) Infection Surveillance in Long-Term Care Facilities

      5. Clostridium difficile Diagnostics in Long-Term Care Facilities

      6. Control of Clostridium (Clostridioides) difficile Infection in Long-Term Care Facilities/Nursing Homes

      7. Antibiotic Stewardship Related to CDI in Long-Term Care Facilities

    Back Matter

  • 44000lei 400.00 lei

    Written by an international, interdisciplinary team of physicians, veterinarians, virologists, medical microbiologists, and parasitologists, Zoonoses: Infectious Diseases Transmissible from Animals to Humans covers zoonotic pathogens as agents of emergence and reemergence of zoonotic diseases, opportunistic zoonotic infections, risks of iatrogenic transmission and xenotransplantation, imported zoonotic infections, food-borne zoonoses, transmissible spongiform encephalopathies, and of warfare. Zoonoses is a valuable physician's reference that covers all aspects of epidemiology, diagnosis and differential diagnosis as well as therapy and prophylaxis of zoonotic diseases caused by bacteria, viruses, parasites, and fungi. Today, more than 200 diseases occurring in humans and animals are known to be mutually transmitted. Classic infectious diseases such as rabies, plague, and yellow fever have not been eradicated despite major efforts. New zoonotic diseases are appearing due to global conditions such as overpopulation, wars, and food scarcity, which facilitate human contact with rodents, stray animals, and their parasites. In addition, humans are unwittingly becoming accidental hosts and new links in an infectious chain by engaging in activities such as survival training, which involves camping in open areas, and consumption of raw or insufficiently cooked food. Zoonotic infections cause a variety of symptoms that often do not provide clear evidence of a known disease. Zoonoses, Fourth Edition, describes most occurring worldwide zoonoses and facilitates the identification, diagnosis, and treatment of zoonotic infections. Written by a team of doctors, medical microbiologists and veterinarians, this revised and updated edition—translated from the noted German reference Zoonosen—covers all aspects of the epidemiology and prevention of zoonotic diseases supported by clear descriptions of various illnesses. Specifically, this fourth edition covers zoonoses caused by: • Viruses, bacteria, fungi, and parasites • infections caused by animal bites • infections and intoxications by animal foods • iatrogenic transmission of zoonotic pathogens

  • 410.00 lei

    Staying true to the unique, problem-oriented approach of Dr. Hugh Moffet’s previous editions, the fifth edition of Moffet’s Pediatric Infectious Diseases walks the reader step by step through diagnosis and management using a signs and symptoms approach. This patient-oriented structure leads to a logical development of a differential diagnosis and evaluation and treatment plan, offering clear steps to confirm the diagnosis and provide appropriate therapy.

    Key Features:

    • A patient-focused, problem-oriented approach helps you develop the thought process that leads to more accurate diagnoses and better patient care – no matter how complex the patient presentation.
    • Greatly revised content throughout, including new medications, new names of known pathogens, new practice guidelines, and extensive revisions to chapters on urinary syndromes, hepatitis syndromes, and HIV infection and AIDS.
    • Newly streamlined format features the most notable suggested readings, more boxes and tables, new clinical pearls, and new key points that summarize must-know information in each chapter.
    • New two-color design and updated and expanded illustrations bring the text visually up to date and facilitate faster and easier mastery of the material.
    • An experienced author team now includes Dr. Armando Correa, a pediatric infectious diseases physician who practices general pediatrics.
    Your book purchase includes a complimentary download of the enhanced eBook for iOS, Android, PC & Mac. Take advantage of these practical features that will improve your eBook experience: 
    • The ability to download the eBook on multiple devices at one time — providing a seamless reading experience online or offline
    • Powerful search tools and smart navigation cross-links allow you to search within this book, or across your entire library of VitalSource eBooks
    • Multiple viewing options offer the ability to scale images and text to any size without losing page clarity as well as responsive design
    • The ability to highlight text and add notes with one click — as well as share with friends and colleagues.

  • 50000lei 450.00 lei

    There are approximately 4 million newborns annually in the United States, including 400,000 infants born preterm.  This care occurs in nurseries of all acuity levels, sizes, and regions across the country and is provided by a variety of providers, including pediatricians, family practice doctors, nurse practitioners, and physician assistants.  The most common complication during the newborn period is suspected or proven infection – either those acquired during the delivery itself or before delivery in the womb.  Indeed, 4 of the 8 most commonly-prescribed medications in newborns annually are antibiotics. Therefore, these providers must all be knowledgeable about the clinical presentation, epidemiology, and approach to diagnosis, treatment and prevention of neonatal infections.  However, many of these nurseries do not have convenient access to pediatric infectious disease consultation or support, and would benefit from a convenient reference guide.

    This book effectively and succinctly covers the pathophysiology, epidemiology, clinical presentation, approach to diagnosis and treatment, and important aspects of preventative care for the most frequently encountered neonatal and congenital infections.  The first section discusses common neonatal infections (i.e., those acquired during or after delivery), including sepsis, meningitis, pneumonia, and other focal infections.  The second section covers the most frequently encountered congenital infections (i.e., those acquired via the placenta while the fetus is still in-utero).  Finally, the concluding section discusses the basics of infection prevention in the nursery setting, including general principles of infection prevention, how to apply those principles to families, and how to manage a suspected outbreak of infection within a nursery.

    This book is a unique contribution to the field. Existing texts such as the AAP Red Book fold neonatal infections in within chapters on a given pathogen, but the information is difficult to find and access quickly.  By covering neonatal and congenital infections thoroughly while still keeping each section clear and concise, this Handbook will be a valuable resource for the busy nursery provider.

  • 50600lei 450.00 lei

    This book is designed to present a comprehensive and state-of the-art update that covers the pathophysiology, epidemiology, and clinical presentation of the most frequently encountered STIs in adolescence and young adulthood. The introductory sections discuss more general themes including approaches to obtaining a sexual history and exam, concerns of sexual minority youth, ethical and legal considerations, and health disparities in STIs in this population. Subsequent chapters are organized by pathogen such as herpes simplex virus, and human immunodeficiency virus, or clinical syndrome including pelvic inflammatory disease, and vaginitis. Each chapter begins with a case study to illustrate key characteristics of the disease process in question and includes rich illustrations, resources, and guidelines. Written by experts in the field, the text includes a review of epidemiology, pathophysiology, treatment, prevention, and adolescent-specific considerations that is vital to working with this important population.

  • 58900lei 515.00 lei



    Now in four convenient volumes, Fields Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Fields Virology: Emerging Viruses, Seventh Edition covers recent changes in emerging viruses, providing new or extensively revised chapters that reflect these advances in this dynamic field.

    Bundled with the eBook, which will be updated regularly as new information about each virus is available, including coronavirus and COVID-19, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physicians, as well as medical students pursuing a career in infectious diseases.

    • Covers both basic science and medical features of each virus, emphasizing viruses of medical importance and interest, while also including other viruses in specific cases where more is known about their mechanisms of replication or pathogenesis.
    • Covers virus evolution, as well as Coronoviridae, Picornaviridae, Enteroviruses, Caliciviridae, Hepatitis C Virus, Filoviridae, Henipaviruses, Orthomyxoviruses, Bunyavirales, Arenaviridae, and much more.
    • Features over 500 full-color illustrations, including key figures for use as lecture slides.
    • Provides quick, flexible access to current information both in print and in an improved eBook format, searchable across all volumes.
    • Discusses virus structure, virus entry, replication, and assembly, virus-host cell interactions, host immune responses and vaccines, antiviral therapeutics, virus evolution and immunization.

     New and forthcoming Fields Virology volumes, available in print and eBook format, which are sold separately:

    • Emerging Viruses
    • DNA Viruses
    • RNA Viruses
    • Fundamental Viruses

    Enrich Your eBook Reading Experience

    • Read directly on your preferred device(s), such as computer, tablet, or smartphone.
    • Easily convert to audiobook, powering your content with natural language text-to-speech.


    Table of Contents:

    1.    Cover

    2.    Title Page

    3.    Copyright

    4.    Contibutors

    5.    Preface

    6.    Contents

    7.    1 Virus Evolution



    10.  The Origins of Viruses

    11.  The Time Scale of Virus Evolution

    12.  Codivergence and Cross-Species Transmission in Virus Evolution

    13.  Metagenomics and Virus Evolution


    15.  Mutation and Nucleotide Substitution in Viruses

    16.  Natural Selection and Genetic Drift in Virus Evolution

    17.  Intra- and Interhost Diversity and Transmission Bottlenecks

    18.  Evolutionary Interactions: Epistasis, Defecting Interfering Particles, and Complementation

    19.  The Evolution of Viral Recombination

    20.  The RNA Virus Quasispecies


    22.  The Evolution of Virus Genome Size

    23.  The Evolution of Genome Organization

    24.  Lateral Gene Transfer and Modular Evolution

    25.  2 Picornaviridae: The Viruses and Their Replication



    28.  Physical Properties

    29.  Ratio of Particles to Infectious Viruses

    30.  High-Resolution Structure of the Virus Particle

    31.  Surface of the Virus Particle

    32.  Interior of the Virus Particle

    33.  Hydrophobic Pocket

    34.  Myristate

    35.  Neutralizing Antigenic Sites


    37.  Genetics


    39.  Attachment

    40.  Entry into Cells

    41.  Translation of the Viral RNA

    42.  Processing of the Viral Polyprotein

    43.  Viral RNA Synthesis


    45.  Misincorporation of Nucleotides

    46.  Recombination

    47.  Codon Usage



    50.  Inhibition of 5′ End–Dependent mRNA Translation

    51.  Modulation of eIF4F Activity

    52.  Stress-Associated RNA Granules

    53.  Inhibition of Cellular RNA Synthesis

    54.  Inhibition of Nucleocytoplasmic Trafficking

    55.  Inhibition of Protein Secretion

    56.  Metabolic Reprogramming

    57.  Cell Death and Virus Release


    59.  3 Enteroviruses: Polioviruses, Coxsackieviruses, Echoviruses, and Newer Enteroviruses

    60.  HISTORY


    62.  Physical and Chemical Properties

    63.  Antigenic Characteristics and Taxonomy

    64.  Propagation and Assay in Cell Culture

    65.  Infection in Experimental Animals: Host Range

    66.  Other Human Picornaviruses


    68.  Entry into the Host

    69.  Site of Primary Replication

    70.  Spread in the Host

    71.  Cell and Tissue Tropism

    72.  Immune Response

    73.  Release from Host

    74.  Virulence

    75.  Persistence


    77.  Demographics

    78.  Transmission

    79.  Prevalence and Disease Incidence

    80.  Molecular Epidemiology


    82.  Poliomyelitis

    83.  Postpolio Syndrome and Amyotrophic Lateral Sclerosis

    84.  Acute Flaccid Myelitis

    85.  Meningitis and Encephalitis

    86.  Cardiac Disease

    87.  Muscle Disease Including Pleurodynia

    88.  Diabetes

    89.  Eye Infections

    90.  Respiratory Infections

    91.  Herpangina and Hand-Foot-and-Mouth Disease

    92.  Neonate and Infant Disease

    93.  DIAGNOSIS

    94.  Differential and Presumptive Diagnosis

    95.  Laboratory Diagnosis


    97.  Treatment

    98.  Vaccines

    99.  Poliovirus Vaccine and Eradication

    100.               PERSPECTIVES

    101.               4 Caliciviridae: The Viruses and Their Replication

    102.               HISTORY

    103.               CLASSIFICATION

    104.               VIRION STRUCTURE


    106.               Viral Proteins

    107.               STAGES OF REPLICATION

    108.               Replication Strategy

    109.               Mechanism of Attachment

    110.               Mechanism of Entry and Intracellular Trafficking

    111.               Uncoating

    112.               Translation

    113.               Replication of Genomic Nucleic Acid

    114.               Assembly

    115.               Release

    116.               PATHOGENESIS AND PATHOLOGY

    117.               Entry into the Host

    118.               Site of Primary Replication

    119.               Cell and Tissue Tropism

    120.               Spread in the Host

    121.               Immune Response

    122.               Release from Host and Transmission

    123.               Virulence

    124.               Persistence

    125.               EPIDEMIOLOGY

    126.               Age

    127.               Morbidity and Mortality

    128.               Origin and Spread of Epidemics

    129.               Prevalence and Seroepidemiology

    130.               Genetic Diversity of Virus

    131.               CLINICAL FEATURES

    132.               DIAGNOSIS

    133.               Differential

    134.               Laboratory

    135.               PREVENTION AND CONTROL

    136.               Treatment

    137.               Vaccines

    138.               Infection Control

    139.               PERSPECTIVE

    140.               5 Togaviridae: The Viruses and Their Replication


    142.               VIRION STRUCTURE

    143.               Structure of Mature Virion

    144.               Structure of Immature Virion

    145.               The Structural Proteins of the Virion


    147.               ALPHAVIRUS REPLICATION

    148.               Mechanism of Attachment and Receptors

    149.               Mechanisms of Entry, Membrane Fusion, and Uncoating

    150.               Translation and the Role of Viral-Encoded Replication Proteins

    151.               Transcription and Replication of Genomic Nucleic Acid

    152.               Assembly of Nucleocapsid Core, Glycoprotein Synthesis, and Processing

    153.               Virion Budding

    154.               Effects on the Host Cell

    155.               Defective Interfering Genomes and Replicon Systems

    156.               RUBIVIRUS REPLICATION

    157.               Virion Structure and Entry

    158.               Transcription, Translation, and Genome Replication

    159.               Virus Assembly

    160.               PERSPECTIVES

    161.               6 Alphaviruses

    162.               HISTORY

    163.               INFECTIOUS AGENTS

    164.               Propagation and Assay in Tissue Culture

    165.               Biological Characteristics

    166.               Antigenic Composition

    167.               Evolution and Phylogeny


    169.               Entry

    170.               Sites of Primary Replication

    171.               Spread

    172.               Cell and Tissue Tropism

    173.               Immune Responses

    174.               Pathological Changes

    175.               Release and Transmission

    176.               Veterinary Correlates and Animal Models

    177.               Virulence

    178.               Persistence

    179.               Congenital Infection


    181.               Entry and Sites of Primary Replication

    182.               Spread

    183.               Pathology, Persistence, and Host Response


    185.               Eastern Equine Encephalitis

    186.               Western Equine Encephalitis

    187.               Venezuelan Equine Encephalitis


    189.               Chikungunya

    190.               O’nyong-Nyong

    191.               Ross River

    192.               Sindbis

    193.               Barmah Forest

    194.               Mayaro and Una

    195.               OTHER ALPHAVIRUSES

    196.               Semliki Forest

    197.               Other SFV-Related Viruses

    198.               Salmonid Alphaviruses

    199.               DIAGNOSIS

    200.               PREVENTION AND CONTROL

    201.               Treatment

    202.               Vaccines

    203.               Other

    204.               PERSPECTIVE

    205.               7 Flaviviridae: The Viruses and Their Replication

    206.               INTRODUCTION

    207.               Family Classification

    208.               Family Characteristics and Replication Cycle

    209.               FLAVIVIRUSES

    210.               Background and Classification

    211.               Structure and Physical Properties of the Virion

    212.               Binding and Entry

    213.               Genome Structure

    214.               Translation and Proteolytic Processing

    215.               Features of the Structural Proteins

    216.               Features of the Nonstructural Proteins

    217.               Ultrastructure and Biogenesis of the Flavivirus Replication Organelle

    218.               RNA Replication

    219.               Assembly and Release of Particles from Flavivirus-Infected Cells

    220.               HEPACIVIRUSES

    221.               Background and Classification

    222.               Structure and Physical Properties of the Virion

    223.               Binding and Entry

    224.               Genome Structure

    225.               Translation and Proteolytic Processing

    226.               Features of the Structural Proteins

    227.               Features of the Nonstructural Proteins

    228.               Ultrastructure and Biogenesis of the HCV Replication Organelle

    229.               RNA Replication

    230.               Virus Assembly

    231.               PEGIVIRUSES

    232.               Background and Classification

    233.               Clinical Perspective

    234.               Virion Structure and Entry

    235.               Genome Structure and Expression

    236.               Structural Proteins

    237.               Nonstructural Proteins

    238.               PESTIVIRUSES

    239.               Background and Classification

    240.               Structure and Physical Properties of the Virion

    241.               Binding and Entry

    242.               Genome Structure

    243.               Translation and Polyprotein Processing

    244.               Npro Autoprotease

    245.               Pestivirus Structural Proteins

    246.               Pestivirus Nonstructural Proteins

    247.               RNA Replication

    248.               Assembly and Release of Virus Particles

    249.               Pathogenesis of Mucosal Disease and the Generation of cp Pestiviruses

    250.               PERSPECTIVES

    251.               8 Hepatitis C Virus

    252.               HISTORY

    253.               INFECTIOUS AGENT

    254.               Classification

    255.               HCV Particle Morphology

    256.               The HCV Replication Cycle

    257.               Genetic Diversity and Evolution

    258.               PATHOGENESIS AND PATHOLOGY

    259.               Spread

    260.               Entry into the Host

    261.               Cell and Tissue Tropism

    262.               Immune Response

    263.               EPIDEMIOLOGY

    264.               Morbidity and Mortality

    265.               Prevalence and Seroepidemiology

    266.               CLINICAL FEATURES

    267.               Acute HCV

    268.               Chronic HCV

    269.               DIAGNOSIS

    270.               Differential Diagnosis

    271.               Laboratory

    272.               Prevention and Control

    273.               PERSPECTIVE

    274.               9 Flaviviruses: Dengue, Zika, West Nile, Yellow Fever and Other Flaviviruses


    276.               Molecular Phylogeny and Evolution

    277.               Global Distribution

    278.               FLAVIVIRUS COMPOSITION

    279.               Flavivirus Structural Proteins

    280.               Flavivirus Assembly and Structure

    281.               Subviral Particles

    282.               Virion Heterogeneity and Dynamics


    284.               Dengue Virus

    285.               Zika Virus

    286.               Yellow Fever Virus

    287.               West Nile Virus

    288.               Japanese Encephalitis Virus

    289.               St. Louis Encephalitis Virus

    290.               Tick-Borne Encephalitis Viruses

    291.               PATHOGENESIS AND IMMUNITY

    292.               Virus Attachment

    293.               The Cell Biology of Flavivirus Entry

    294.               Flavivirus Tropism

    295.               Mechanisms of Dissemination

    296.               Mechanisms of Immune Control—Innate Immunity

    297.               Humoral Immunity

    298.               T-Cell–Mediated Control

    299.               Flavivirus Immune Evasion


    301.               Dengue Virus

    302.               Zika Virus

    303.               Yellow Fever Virus

    304.               West Nile Virus

    305.               FLAVIVIRUS VACCINES

    306.               Flavivirus Vaccine Platforms

    307.               Yellow Fever Virus

    308.               Dengue Virus

    309.               Japanese Encephalitis Virus

    310.               Tick-Borne Encephalitis Virus

    311.               Zika Virus

    312.               West Nile Virus

    313.               ACKNOWLEDGMENTS

    314.               10 Coronaviridae: The Viruses and Their Replication

    315.               HISTORY

    316.               CLASSIFICATION

    317.               VIRION STRUCTURE

    318.               Virus and Nucleocapsid

    319.               Virion Structural Proteins


    321.               Basic and Accessory Genes

    322.               Coronavirus Genetics

    323.               CORONAVIRUS REPLICATION

    324.               Virion Attachment to Host Cells

    325.               Viral Entry and Uncoating

    326.               Expression of the Replicase–Transcriptase Complex

    327.               Viral RNA Synthesis

    328.               Assembly and Release of Virions


    330.               General Principles

    331.               Animal Coronavirus Infections

    332.               Human Coronavirus Infections

    333.               Immune Response and Viral Evasion of the Immune Response

    334.               EPIDEMIOLOGY

    335.               Human Coronaviruses Other Than SARS-CoV and MERS-CoV

    336.               Severe Acute Respiratory Syndrome

    337.               Middle East Respiratory Syndrome

    338.               Genetic Diversity of Coronaviruses

    339.               CLINICAL FEATURES

    340.               Human Coronaviruses Other Than SARS-CoV and MERS-CoV

    341.               SARS-CoV Infections

    342.               MERS-CoV Infections

    343.               DIAGNOSIS

    344.               TREATMENT

    345.               PREVENTION

    346.               PERSPECTIVES

    347.               11 Filoviridae

    348.               HISTORY

    349.               Marburgviruses

    350.               Ebolaviruses

    351.               Cuevaviruses

    352.               Striaviruses

    353.               Thamnoviruses

    354.               Dianloviruses

    355.               Other Filoviruses

    356.               CLASSIFICATION

    357.               VIRION STRUCTURE


    359.               Filovirus Genomic Organization

    360.               Filovirus Genome Expression Products

    361.               Filovirus GP Gene Expression Products

    362.               STAGES OF REPLICATION

    363.               Filovirion Cell-Surface Attachment and Host Cell Entry

    364.               Filovirus Genome Replication and Transcription

    365.               Filovirion Assembly and Budding

    366.               PATHOGENESIS AND PATHOLOGY

    367.               Pathogenesis Following Filovirus Host Entry

    368.               Filovirus Intrahost Distribution and Pathologic Consequences

    369.               Immune Response to Filovirus Infection

    370.               Virulence

    371.               Persistence

    372.               EPIDEMIOLOGY

    373.               CLINICAL FEATURES

    374.               DIAGNOSIS

    375.               Differential Diagnosis

    376.               Laboratory Diagnosis

    377.               PREVENTION AND CONTROL

    378.               Prevention

    379.               Treatment

    380.               PERSPECTIVE

    381.               FOOTNOTE

    382.               ACKNOWLEDGMENTS

    383.               DISCLAIMER

    384.               12 Paramyxoviridae: The Viruses and Their Replication

    385.               INTRODUCTION

    386.               CLASSIFICATION


    388.               VIRION STRUCTURE


    390.               The Nucleocapsid Protein

    391.               The P Gene and Its Encoded Proteins

    392.               The Large Protein

    393.               The Matrix Protein

    394.               Envelope Glycoproteins

    395.               Other Envelope Proteins

    396.               STAGES OF REPLICATION

    397.               General Aspects

    398.               Virus Adsorption and Entry

    399.               Viral RNA Synthesis

    400.               Genome Replication

    401.               Virion Assembly and Release


    403.               Antagonists of Interferon Synthesis

    404.               Antagonists of Interferon Signaling Pathways


    406.               13 Henipaviruses: Hendra and Nipah Viruses

    407.               HISTORY

    408.               INFECTIOUS AGENT

    409.               Classification

    410.               Propagation in Cell Culture and Cytopathic Effect

    411.               Virus Morphology

    412.               Genome Length and Organization

    413.               Virus Proteins and Their Properties

    414.               Host Range

    415.               PATHOGENESIS AND PATHOLOGY

    416.               Entry Into the Host

    417.               Site of Primary Replication, Virus Spread, and Cell and Tissue Tropism

    418.               Immune Response

    419.               Release from Host and Transmission

    420.               Virulence

    421.               Persistence

    422.               EPIDEMIOLOGY

    423.               Age

    424.               Morbidity and Mortality

    425.               Origin and Spread of Epidemics

    426.               Genetic Diversity

    427.               CLINICAL FEATURES

    428.               Incubation Period

    429.               Acute Clinical Features

    430.               Outcome of Infection

    431.               DIAGNOSIS

    432.               PREVENTION AND CONTROL

    433.               Drugs and Small Molecules

    434.               Peptide Fusion Inhibitors

    435.               Vaccines

    436.               Passive Immunization

    437.               PERSPECTIVE

    438.               14 Orthomyxoviridae: The Viruses and Their Replication

    439.               INTRODUCTION

    440.               CLASSIFICATION

    441.               VIRION STRUCTURE


    443.               Influenza Viruses

    444.               Thogoto Virus

    445.               Quaranjavirus

    446.               Isavirus (Infectious Salmon Anemia Virus)

    447.               STAGES OF VIRAL REPLICATION

    448.               Mechanism of Attachment

    449.               Mechanism of Entry

    450.               Mechanism of Fusion and Uncoating

    451.               Influenza Virus Transcription and Replication

    452.               Polyadenylation

    453.               Splicing

    454.               Replication Products: cRNA and vRNA

    455.               The Switch from Transcription to Replication

    456.               Regulation of Viral Gene Expression

    457.               Virus Assembly and Release

    458.               Interactions of Influenza Virus with the Host Cell

    459.               REVERSE GENETICS


    461.               PERSPECTIVES

    462.               ACKNOWLEDGMENTS

    463.               15 Orthomyxoviruses

    464.               INTRODUCTION

    465.               NOMENCLATURE

    466.               Seroarcheology

    467.               Virus Isolation

    468.               Virus Propagation


    470.               Evolutionary Rates of Influenza A Viruses

    471.               Host-Specific Lineages, and Geographic Segregation of Influenza A Viruses

    472.               Host-Specific Amino Acids

    473.               Quasispecies

    474.               Evolution in Influenza B and C Viruses

    475.               INFLUENZA VIRUS GENETICS

    476.               Reassortment

    477.               Recombination

    478.               Defective Interfering (DI) Viral RNAs and Particles

    479.               Reverse Genetics


    481.               The Pandemic of 1918/1919—Spanish Influenza (H1N1)

    482.               The Pandemic of 1957—Asian Influenza (H2N2)

    483.               The Pandemic of 1968—Hong Kong Influenza (H3N2)

    484.               The Reemergence of H1N1 Viruses in 1977—Russian Influenza

    485.               The H1N1 Pandemic in 2009 [A(H1N1)pdm09]


    487.               Antigenic Drift

    488.               Antigenic Shift

    489.               Transmission Among Humans

    490.               Seasonality

    491.               Influenza Disease Burden

    492.               Surveillance


    494.               Infections of Humans with H5 Viruses of the A/goose/Guangdong/1/1996 Lineage

    495.               Infections of Humans with Low and Highly Pathogenic H7N9 Viruses

    496.               Infections of Humans with Other Avian Influenza Viruses

    497.               Infections of Humans with Swine Influenza Viruses


    499.               Influenza in Birds

    500.               Influenza in Swine

    501.               Influenza in Horses

    502.               Influenza in Dogs

    503.               Influenza in Cats

    504.               Influenza in Seals and Whales

    505.               Influenza in Mink

    506.               Influenza in Bats

    507.               Experimental Infections

    508.               Molecular Determinants of Host-Range Restriction and Pathogenesis

    509.               The HA Protein

    510.               The NS1 Protein

    511.               The Replication Complex

    512.               The PB1-F2 Protein

    513.               The NA Protein


    515.               Pattern of Virus Shedding

    516.               Pathology and Pathophysiology

    517.               Clinical Features

    518.               Lower Respiratory Tract Complications

    519.               Extrapulmonary Manifestations

    520.               Toxic Shock Syndrome

    521.               Infection During Pregnancy

    522.               Infection in Immunosuppressed Patients

    523.               Influenza B and C Virus Infections

    524.               Innate Immune Responses

    525.               Adaptive Immune Responses

    526.               DIAGNOSIS

    527.               Clinical Diagnosis

    528.               Virus Isolation

    529.               Rapid Influenza Diagnostic Tests (RIDT)

    530.               Polymerase Chain Reaction–Based Tests

    531.               Rapid Nucleic Acid Amplification Tests (NAAT)

    532.               Role of Viral Diagnosis in Clinical Decision-Making

    533.               ANTIVIRALS

    534.               M2 Ion Channel Inhibitors

    535.               Neuraminidase Inhibitors

    536.               Polymerase Inhibitors

    537.               Combination Therapy

    538.               Experimental Antivirals Against Influenza

    539.               VACCINES

    540.               Currently Available Vaccines

    541.               Safety

    542.               Immune Responses to Vaccination

    543.               Efficacy (Results of Randomized Prospective Studies)

    544.               Effectiveness (Results of Observational Studies)

    545.               Secondary Protection

    546.               Maternal Immunization

    547.               Recommendations for Vaccine Use

    548.               Vaccines for Pandemic Influenza

    549.               Strategies for More Broadly Protective Vaccines

    550.               PERSPECTIVES

    551.               16 Bunyavirales: The Viruses and Their Replication

    552.               INTRODUCTION

    553.               HISTORY AND CLASSIFICATION

    554.               Hantaviridae Family

    555.               Nairoviridae Family

    556.               Peribunyaviridae Family

    557.               Phenuiviridae Family

    558.               Tospoviridae Family

    559.               VIRION STRUCTURE


    561.               Viral Genome

    562.               Coding Strategies of Viral Genes

    563.               STAGES OF REPLICATION

    564.               Attachment and Entry

    565.               Transcription and Replication

    566.               Translation and Processing of Viral Proteins

    567.               Morphogenesis


    569.               Cytopathic Effects

    570.               Host-Cell Metabolism

    571.               Host-Cell Responses and Viral Suppression

    572.               17 Orthohantavirus, Orthonairovirus, Orthobunyavirus and Phlebovirus

    573.               INTRODUCTION


    575.               Pathogenesis and Pathology

    576.               Clinical Features

    577.               Epidemiology and Ecology

    578.               Diagnosis

    579.               Prevention and Control

    580.               NAIROVIRIDAE

    581.               Crimean-Congo Hemorrhagic Fever Virus


    583.               Distribution and Significance

    584.               Epidemiology

    585.               Morbidity/Mortality

    586.               Clinical Features

    587.               Pathogenesis and Pathology

    588.               Diagnosis

    589.               Prevention and Control


    591.               Rift Valley Fever and Sandfly Group


    593.               Severe Fever with Thrombocytopenia Syndrome Virus

    594.               Heartland Virus

    595.               PERSPECTIVES

    596.               18 Arenaviridae: The Viruses and Their Replication

    597.               HISTORY


    599.               VIRION STRUCTURE


    601.               Arenavirus Genomic Organization

    602.               Arenavirus Proteins

    603.               STAGES OF REPLICATION

    604.               Cell Attachment and Entry

    605.               Expression and Replication of the Viral Genome

    606.               Assembly and Budding

    607.               PATHOGENESIS AND PATHOLOGY

    608.               Coagulopathy and Vascular Dysfunction

    609.               Pathology

    610.               Immune Responses

    611.               EPIDEMIOLOGY

    612.               Lassa Fever

    613.               Lymphocytic Choriomeningitis

    614.               Argentinian Hemorrhagic Fever

    615.               Bolivian Hemorrhagic Fever

    616.               Venezuelan Hemorrhagic Fever

    617.               CLINICAL FEATURES

    618.               Lassa Fever and Other Old World Mammarenaviral Diseases

    619.               Lymphocytic Choriomeningitis

    620.               New World Mammarenaviral Hemorrhagic Fevers

    621.               DIAGNOSIS

    622.               Lassa Fever

    623.               Lymphocytic Choriomeningitis

    624.               New World Mammarenaviral Hemorrhagic Fevers

    625.               PREVENTION AND CONTROL

    626.               Medical Management

    627.               Antiviral Drugs

    628.               Antibody Therapy

    629.               Vaccines

    630.               PERSPECTIVE

    631.               ACKNOWLEDGMENTS

    632.               DISCLAIMER

    633.               Index


  • 60600lei 550.00 lei

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  • Hepatitis C Virus Treatment
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    This book introduces readers to Direct Acting Antiviral (DAAs) agents, newly developed drugs to treat chronic hepatitis C virus infection, which have an excellent anti-viral effect on virus replication. These drugs have been developed to enhance the effect of interferon and ribavirin, as the resistant strains against each drug have been described both in vitro and in vivo and the existences of naturally occurring variants have been reported. However, since the combination of different classes of DAAs is sufficient to completely eradicate the virus without the need for interferon or ribavirin, the current treatment regimen does not include interferon. Ribavirin is used in combination with sofosbuvir, a potent polymerase inhibitor, to enhance its antiviral effects.

    Hepatitis C Virus Treatment offers readers a comprehensive guide to hepatitis C; describing the resistance profiles against these drugs and shedding light on the difficulties involved in DAA therapy and the direction of future treatments, it will equip doctors to understand the essentials of treating the disease. It also describes in detail new and innovative DAA treatments, the effects of the agents, and the characteristics of resistance, providing cutting-edge information not only for hepatologists, but also for researchers, clinical residents, and medical students.

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    The Oxford Textbook of Medical Mycology is a comprehensive reference text which brings together the science and medicine of human fungal disease. Written by a leading group of international authors to bring a global expertise, it is divided into sections that deal with the principles of mycology, the organisms, a systems-based approach to management, fungal disease in specific patient groups, diagnosis, and treatment.

    The detailed clinical chapters take account of recent international guidelines on the management of fungal disease. With chapters covering recent developments in taxonomy, fungal genetics and other "omics", epidemiology, pathogenesis, and immunology, this textbook is well suited to aid both scientists and clinicians.

    The extensive illustrations, tables, and in-depth coverage of topics, including discussion of the non-infective aspects of allergic and toxin mediated fungal disease, are designed to aid the understanding of mechanisms and pathology, and extend the usual approach to fungal disease.

    This textbook is essential reading for microbiologists, research scientists, infectious diseases clinicians, respiratory physicians, and those managing immunocompromised patients. Part of the Oxford Textbook in Infectious Disease and Microbiology series, it is also a useful companion text for students and trainees looking to supplement mycology courses and microbiology training.

  • 73000lei 665.00 lei

    With the rapid development of economy and international communication, world population mobility increase significantly. As migrating population is one of vulnerable populations to infectious diseases, strengthening monitoring system and intervention approaches will be a key factor in controlling the spread of infectious diseases.

    This book is intended to provide valuable information on creating effective prevention and intervention strategies of tuberculosis, taking Shenzhen, one of typical immigrant cities, as an example.

    Followed by overview of tuberculosis, the control strategy, diagnosis and treatment of tuberculosis, drug resistant tuberculosis, and HIV-associated tuberculosis in migrating population is introduced. In addition, application of innovative technologies, for example, internet, molecular biology, and artificial intelligence in tuberculosis control is presented. It will be a useful reference for practitioners in centers for infectious disease control and prevention, hospitals, academic institutions, as well as staff in government agencies and non-government organizations with interests in tuberculosis prevention and control.


    Front Matter

      1. Overview of Tuberculosis

      2. Epidemiology of Tuberculosis in Migrating Population

      3. Strategy of TB Control in Migrating Population

      4. Prevention, Diagnosis, and Treatment of TB in the Migrating Population

      5. Management of Migrating Population with Tuberculosis

      6. TB Control in Schools

      7. Control of Drug-Resistant TB

      8. Control of TB/HIV Coinfection

      9. New Technologies for TB Control in Migrating Population

      10. Emergency Management of TB Emergency Public Health Events

  • 77700lei 700.00 lei


    The fourth edition of this best-selling Red Book® image companion aids in the diagnosis and treatment of more than 160 of the most commonly seen pediatric infectious diseases. This edition features Zika virus, chikungunya, serious bacterial infections caused by Enterobacteriaceae, Moraxella catarrhalis, human parechovirus, rhinovirus, staphylococcal food poisoning, Staphylococcus aureus, coagulase-negative staphylococcal infections, Ureaplasma urealyticum, and Ureaplasma parvum.


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    Concise text descriptions walk the reader through the diagnosis, evaluation, and management essentials for each condition.


    • Clinical manifestations
    • Epidemiology
    • Diagnostic tests
    • Etiology
    • Incubation period
    • Treatment


    Contents include:

    • Adenovirus Infections
    • Bacteroides and Prevotella Infections
    • Candidiasis
    • Cystosporiasis (formerly Isosporiasis)
    • Epstein-Barr Virus Infections (Infectious Mononucleosis)
    • Human Herpesvirus 6 (including Roseola) and 7
    • Lyme Disease (Lyme borreliosis, Borrelia burgdorferi Infection)
    • Meningococcal Infections
    • Human Papillomaviruses
    • Pelvic inflammatory disease
    • Pneumococcal Infections
    • Respiratory Syncytial Virus
    • Group A Streptococcal Infections
    • Staphylococcus aureus
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  • Water-Associated Infectious Diseases
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    84300lei 715.00 lei

    This book provides a comprehensive overview of the different water-associated infectious diseases and their linked pathogens with plausible strategies for their mitigation. Although, we are in the era of 21st century having most of the advanced technologies at hand, yet water-associated infectious diseases are the major contributors towards the worldwide morbidity and mortality.

    The book also focuses on the various implementation strategies of sustainable hygienic conditions, discusses the robust, and reliable policies and strategies on a global aspect to provide unprivileged people access to the basic sanitation, hygiene and water. In addition, the book discusses the possible indirect effect of global warming on the spread of infectious diseases through the distribution of associated vectors.


    Front Matter

      1. Introduction to Water-Associated Infectious Diseases

      2. Etiological Agents of Water-Associated Infectious Diseases

      3. Evolution and Interplay of Water-Associated Human Pathogens

      4. Epidemiology of Water-Associated Infectious Diseases

      5. Emerging and Re-emerging Water-Associated Infectious Diseases

      6. Impact of Climate Change on Water-Associated Infectious Diseases

      7. Hazards Associated with Contaminated Water

      8. Global Strategies and Schemes for Preventing Water-Associated Infectious Diseases

      9. Novel Approaches for Detecting Water-Associated Pathogens

      10. Treatment of Water to Prevent Water-Associated Infectious Diseases

      11. Conventional Treatments of Water-Associated Infectious Diseases

      12. Complementary and Alternative Medicine Treatments of Water-Associated Infectious Diseases

  • Infectious Diseases and Nanomedicine II
    La comanda in aproximativ 4 saptamani
    94500lei 765.00 lei

    The book addresses the interdisciplinary scientific approach for the systemic understanding of connections between major human diseases and their treatment regime by applying the tools and techniques of nanotechnology. It also highlights the interdisciplinary collaborative researches for innovation in Biomedical Sciences. The book is a second volume which presents collection of best papers presented in the First International Conference on Infectious Diseases and Nanomedicine held during Dec. 15-18, 2012 in Kathmandu, Nepal.

  • Infectious Diseases and Nanomedicine I
    La comanda in aproximativ 4 saptamani
    95500lei 775.00 lei

    The book addresses the interdisciplinary scientific approach for the systemic understanding of connections between major human diseases and their treatment regime by applying the tools and techniques of nanotechnology. It also highlights the interdisciplinary collaborative researches for innovation in Biomedical Sciences. The book is a first volume which presents collection of best papers presented in the First International Conference on Infectious Diseases and Nanomedicine held during Dec. 15-18, 2012 in Kathmandu, Nepal.

  • Hepatitis B Virus
    La comanda in aproximativ 4 saptamani
    785.00 lei

    This volume serves as a reference for the dissemination of advances made in the study of Hepatitis B Virus (HBV). Hepatitis B Virus: Methods and Protocols details protocols and techniques ranging from cell culture studies to in vivo and clinical immunology. The chapters in this book discuss treatments of in vitro infection systems, analysis and quantification of cccDNA and its mutations; in vitro polymerase activity assays; cellular trafficking of core proteins; intracellular calcium metabolism; detection, cloning, and sequencing of HBV markers; and new strategies aimed at exploiting new mechanisms for drug discovery. The book also covers classical methods for resolution of extracellular viral particles by native gel electrophoresis, and methods for detecting HBV antigens in drug discovery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

    Cutting-edge and comprehensive, Hepatitis B Virus: Methods and Protocols is a valuable tool for researchers to use toward their advanced studies in HBV.

  • 1,01300lei 830.00 lei



    Regarded as the definitive source of information in the field, Infectious Diseases of the Fetus and Newborn Infant remains your indispensable source for authoritative, state-of-the-art answers. Edited by Drs. Wilson, Nizet, Maldonado, Remington, and Klein, this fully updated reference helps you apply the latest evidence-based recommendations in the prevention, diagnosis, and management of infections found in utero, during delivery, and in the neonatal period in both premature and term infants.


    Form a definitive diagnosis and create the best treatment plans possible using evidence-based recommendations and expert guidance from world authorities.

    Locate key content easily and identify clinical conditions quickly thanks to a consistent, highly user-friendly format now featuring a full-color design with hundreds of illustrations, and fresh perspectives from six new authoritative chapter lead authors.

    New To This Edition:

    Explore what’s changing in key areas such as:

                  - emerging problems and concepts in maternal, fetal, and neonatal infectious diseases

                 - anticipation and recognition of infections occurring in utero, during delivery, and in the neonatal period

    Stay on the cutting edge of your field with new and improved chapters including: obstetric factors associated with infections of the fetus and newborn infant; human milk; borella infections; tuberculosis; bordetella pertussis and other bordetella sp infections; herpes simplex; toxoplasmosis; pneumocystis and other less common fungal infections; and healthcare-associated infections in the nursery

    Keep up with the most relevant topics in fetal/neonatal infectious disease including new antimicrobial agents, gram- negative infections and their management, and recommendations for immunization of the fetus/mother.

    Overcome clinical challenges in developing countries where access to proper medical care is limited.

    Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.

    Table Of Contents:

    Section I: General Information

    1. Current Concepts of Infections of the Fetus and Newborn Infant

    2. Neonatal Infections: A Global Perspective

    3. Obstetric Factors Associated with Infections of the Fetus and Newborn Infant

    4. Developmental Immunology and Role of Host Defenses in Fetal and Neonatal Susceptibility to Infection

    5. Human Milk

    Section II: Bacterial Infections

    6. Bacterial Sepsis and Meningitis

    7. Bacterial Infections of the Respiratory Tract

    8. Bacterial Infections of the Bones and Joints

    9. Bacterial Infections of the Urinary Tract

    10. Focal Bacterial Infections

    11. Microorganisms Responsible for Neonatal Diarrhea

    12. Group B Streptococcal Infections

    13. Listeriosis

    14. Staphylococcal Infections

    15. Gonococcal Infections

    16. Syphilis

    17. Borella Infections: Lyme Disease and Relapsing Fever

    18. Tuberculosis

    19. Chlamydia Infections

    20. Mycoplasmal Infections

    21. Bordetella pertussis and Other Bordetella spp. Infections

    Section III: Viral Infections

    22. Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome in the Infant

    23. Varicella, Measles, and Mumps

    24. Cytomegalovirus

    25. Enterovirus and Parechovirus Infections

    26. Hepatitis

    27. Herpes Simplex Virus Infections

    28. Human Parvovirus

    29. Rubella

    30. Less Common Viral Infections

    Section IV: Protozoan, Helminth, and Fungal Infections

    31. Toxoplasmosis

    32. Malaria and Less Common Protozoan and Helminth Infections

    33. Candidiasis

    34. Pneumocystis and Other Less Common Fungal Infections

    Section V: Diagnosis and Management

    35. Healthcare-Associated Infections in the Nursery

    36. Laboratory Aids for Diagnosis of Neonatal Sepsis

    37. Clinical Pharmacology of Antiinfective Drugs

    38. Prevention of Fetal and Early Life Infections Through Maternal-Neonatal Immunization


  • 960.00 lei




    The most practice-oriented guide to diagnosing and managing infectious diseases in children.

    Pediatric Infectious Diseases: Essentials for Practice, Second Edition is filled with practical, clinically relevant guidance for successful infectious disease management. The care of the patient forms the core of this indispensable resource, which also provides perspectives on epidemiology, pathophysiology, and diagnosis that every pediatrician, pediatric hospitalist, and pediatric nurse practitioner needs to know. The book's high-yield coverage includes detailed, yet precise overviews of specific infections and their etiology, along with proven diagnostic and management strategies that readers can incorporate into their practice right away.




    • Tips that tell you what you must know--and do--at every stage of care


    • Diagnostic and treatment algorithms


    • Signs/Symptoms and Differential Diagnosis boxes


    • "When to Refer" boxes, which examine all the relevant clinical considerations


    • Diagnostic Tests--with a realistic emphasis on the right tests to order


    • Medical Treatment coverage that includes drugs, dosages, and administration in an easy-to-read tabular format


    • Convenient icons and a templated chapter design


    • Numerous clinical color photos and didactic diagrams


    • NEW! Clinical Pearls boxes accompany coverage of each infectious disease


    • Updated treatment guidelines and protocols from the CDC


    If you are in need of an up-to-date, clinically relevant guide to treating infectious diseases in pediatric patients, your search ends here.



    Section 1. Practical Aspects

    1Clinical Microbiology

    2Clinical Virology

    3Active immunization, passive immunization and chemoprophylaxis

    4Office infection control (daycare)

    5Hospital infection control6Infectious Diseases Epidemiology

    Section 2 Signs and Symptoms

    7Chronic Abdominal Pain




    11Joint Complaints

    12Neck pain




    Section 3 Infections of Organ Systems

    Part A Neurologic Infections



    18Transverse myelitis

    19Movement disorders

    Part B Ophthalmologic Infections

    20Conjunctivitis in the neonate

    21Conjunctivitis in the older child

    22Periorbital and orbital infections


    Part C Oral Cavity and Neck Infections

    24Pharyngitis and stomatitis

    25Peritonsillar and retropharyngeal abscess

    26Cervical lymphadenitis

    27Gingival and Periodontal Infections

    Part D Upper Respiratory Infections

    28Otitis media

    29Otitis externa



    Part E Lower Respiratory Infections


    33Uncomplicated pneumonia

    34Complicated pneumonia

    35Recurrent pneumonia

    36Childhood tuberculosis 

    Part F Cardiac Infections


    38Myocarditis and Pericarditis

    39Acute rheumatic fever

    Part G Gastrointestinal Infections



    42Antibiotic-associated diarrhea

    Part H Genitourinary Infections

    43Urinary tract infections

    44Pelvic inflammatory diseases

  • 1,28600lei 1050.00 lei



    Trusted by physicians and advanced practice providers through ten standard-setting editions, Fanaroff and Martin's Neonatal-Perinatal Medicine, 11th Edition, remains the reference of choice for expert, multidisciplinary guidance on the management and evidence-based treatment of problems in the mother, fetus, and neonate. An expanded team of international authors, led by Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh of Rainbow Babies and Children's Hospital, brings you up to date with advances in the control of nosocomial infections in preterm infants, genetic disorders and birth defects, the fetal origins of adult disease, the late preterm infants, and much more - all designed to help you improve the quality of life and long-term outcomes of your patients.

    Table Of Contents:


    1. Growth of Neonatal Perinatal Medicine-A Historical Perspective

    2. Epidemiology for Neonatologists

    3. Medical Ethics in Neonatal Care

    4. Legal Issues in Neonatal-Perinatal Medicine

    5. Evaluating and Improving the Quality and Safety of Neonatal Intensive Medicine

    6. Simulation and Debriefing in Neonatal-Perinatal Medicine

    7. Practicing Evidence-based Neonatal-Perinatal Medicine

    8. Perinatal and Neonatal Care in Developing Countries

    9. Social and Economic Contributors to Neonatal Outcome

    Part 2 THE FETUS

    10. Genetic Aspects of Perinatal Disease and Prenatal Diagnosis

    11. Perinatal Ultrasound

    12. Estimation of Fetal Well-Being

    13. Surgical Treatment of the Fetus

    14. Adverse Exposures to the Fetus and Neonate

    15. Intrauterine Growth Restriction

    16. Developmental Origins of Adult Health and Disease


    17. Hypertensive Disorders of Pregnancy

    18. Pregnancy Complicated by Diabetes Mellitus

    19. Obstetric Management of Prematurity

    20. Fetal Effects of Autoimmune Disease

    21. Obstetric Management of Multiple Gestation and Birth

    22. Post-Term Pregnancy

    23. Immune and Nonimmune Hydrops Fetalis

    24. Amniotic Fluid Volume

    25. Perinatal Infections and Chorioamnionitis

    26. Placental Pathology


    27. Anesthesia for Labor and Delivery

    28. Physical Examination of the Newborn

    29. Birth Injuries

    30. Congenital Anomalies


    31. Overview and Initial Management of Delivery Room Resuscitation

    32. Role of Positive Pressure Ventilation in Neonatal Resuscitation

    33. Oxygen Therapy in Neonatal Resuscitation

    34. Chest Compression, Medications, and Special Problems in Neonatal Resuscitation


    35. Thermal Environment of the Intensive Care Nursery

    36. Optimization of the NICU Environment


    37. Biomedical Engineering Aspects of Neonatal Cardiorespiratory Monitoring

    38. Diagnostic Imaging of the Neonate

    39. Anesthesia in the Neonate

    40. The Late Preterm Infant

    41. Nutrient Requirements/Nutritional Support in Premature Neonate

    42. Support for the Family


    43. Principles of Drug Use in the Fetus and Neonate

    44. Principles of Drug Use During Lactation

    45. Pharmacokinetics in Neonatal Medicine

    46. Infants of Substance-Using Mothers


    47. Developmental Immunology

    48. Postnatal Bacterial Infections

    49. Fungal and Protozoal Infections of the Neonate

    50. Viral Infections in the Neonate


    51. Normal and Abnormal Brain Development

    52. White Matter Damage and Encephalopathy of Prematurity

    53. Intracranial Hemorrhage and Vascular Lesions in the Neonate

    54. Hypoxic-Ischemic Encephalopathy

    55. Seizures in Neonates

    56. Hypotonia and Neuromuscular Disease in the Neonate

    57. Intracranial and Calvarial Disorders

    58. Spinal Dysraphisms

    59. Hearing Loss in the Newborn Infant

    60. Early Childhood Neurodevelopmental Outcomes of High-Risk Neonates

    61. The Role of Neonatal Neuroimaging in Predicting Neurodevelopmental Outcomes of Preterm Neonates


    62. Lung Development and Maturation

    63. Assessment of Neonatal Pulmonary Function

    64. Respiratory Distress Syndrome in the Neonate

    65. Assisted Ventilation of the Neonate and Its Complications

    66. Neonatal Respiratory Disorders

    67. Neonatal Apnea and the Foundation of Respiratory Control

    68. Upper Airway Lesions in the Neonate

    69. Bronchopulmonary Dysplasia in the Neonate

    70. Therapy for Cardiorespiratory Failure in the Neonate


    71. Cardiac Embryology

    72. Pulmonary Vascular Development

    73. Prenatal Diagnosis of Congenital Heart Disease

    74. Patent Ductus Arteriosus

    75. Congenital Defects of the Cardiovascular System

    76. Cardiovascular Problems of the Neonate

    77. Disorders of Cardiac Rhythm and Conduction in Newborns

    78. Neonatal Management of Congenital Heart Disease


    79. Hematologic and Oncologic Problems in the Fetus and Neonate

    80. Blood Component Therapy for the Neonate


    81. Development of the Neonatal Gastrointestinal Tract

    82. Gastrointestinal Reflux and Motility in the Neonate

    83. Disorders of Digestion in the Neonate

    84. Selected Gastrointestinal Anomalies in the Neonate

    85. Neonatal Necrotizing Enterocolitis


    86. Disorders of Carbohydrate Metabolism in the Neonate

    87. Disorders of Calcium, Phosphorus, and Magnesium Metabolism in the Neonate

    88. Thyroid Disorders in the Neonate

    89. Disorders of Sex Development

    90. Inborn Errors of Metabolism


    91. Neonatal Jaundice and Liver Disease


    92. Fluids, Electrolytes, and Acid-Base Homeostasis in the Neonate

    93. The Kidney and Urinary Tract of the Neonate

    Part 18 - THE SKIN

    94. The Skin of the Neonate

    Part 19- THE EYE

    95. Examination and Common Problems in the Neonatal Eye

    96. Retinopathy of Prematurity


    97. Musculoskeletal Disorders in Neonates

    98. Bone and Joint Infections in Neonates

    99. Congenital Abnormalities of the Upper and Lower Extremities and Spine


    Appendix A - Therapeutic Agents

    Appendix B - Tables of Normal Values

    Appendix C - Schedule for Immunization of Preterm Infants



  • 1,61700lei 1300.00 lei

    Tropical Infectious Diseases: Principles, Pathogens and Practice, by Drs. Richard L. Guerrant, David H. Walker, and Peter F. Weller, delivers the expert, encyclopedic guidance you need to overcome the toughest clinical challenges in diagnosing and treatin

  • 1,84800lei 1480.00 lei


    Offering unparalleled coverage of infectious diseases in children and adolescents, Feigin & Cherry’s Textbook of Pediatric Infectious Diseases 8th Edition, continues to provide the information you need on epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. This extensively revised edition by Drs. James Cherry, Gail J. Demmler-Harrison, Sheldon L. Kaplan, William J. Steinbach, and Peter J. Hotez, offers a brand-new full-color design, new color images, new guidelines, and new content, reflecting today’s more aggressive infectious and resistant strains as well as emerging and re-emerging diseases


    Discusses infectious diseases according to organ system, as well as individually by microorganisms, placing emphasis on the clinical manifestations that may be related to the organism causing the disease.

    Provides detailed information regarding the best means to establish a diagnosis, explicit recommendations for therapy, and the most appropriate uses of diagnostic imaging.

    New To This Edition:

    Features expanded information on infections in the compromised host; immunomodulating agents and their potential use in the treatment of infectious diseases; and Ebola virus.

    Contains hundreds of new color images throughout, as well as new guidelines, new resistance epidemiology, and new Global Health Milestones.

    Includes new chapters on Zika virus and Guillain-Barré syndrome.

    Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

    Table Of Contents:

    Feigin and Cherry’s Textbook of Pediatric Infectious Diseases, 8th edition

    Part 1 - Host-Parasite Relationships and the Pathogenesis of Infectious Diseases

    1. Molecular Determinants of Microbial Pathogenesis

    2. Normal and Impaired Immunologic Responses to Infection

    3. The Host Response to Infections: The Omics Revolution

    4. Fever: Pathogenesis and Treatment

    5. The Human Microbiome

    6. Epidemiology and Biostatistics of Infectious Diseases

    Part 2 - Infection of Specific Organ Systems

    Section 1 - Upper Respiratory Tract Infections

    7. The Common Cold

    8. Infections of the Oral Cavity

    9. Pharyngitis (Pharyngitis, Tonsillitis, Tonsillopharyngitis, and Nasopharyngitis)

    10. Uvulitis

    11. Peritonsillar, Retropharyngeal, and Parapharyngeal Abscesses

    12. Cervical Lymphadenitis

    13. Parotitis

    14. Rhinosinusitis

    15. Otitis Externa

    16. Otitis Media

    17. Mastoiditis

    18. Croup (Laryngitis, Laryngotracheitis, Spasmodic Croup, Laryngotracheobronchitis, Bacterial Tracheitis, and Laryngotracheobronchopneumonitis) and Epiglottitis (Supraglottitis)

    Section 2 - Lower Respiratory Tract Infections

    19. Acute Bronchitis

    20. Chronic Bronchitis

    21. Bronchiolitis and Infectious Asthma

    22. Pediatric Community-Acquired Pneumonia

    23. Empyema and Lung Absess

    24. Children’s Interstitial Lung Disease and Hypersensitivity Pneumonitis

    25. Cystic Fibrosis

    Section 3 - Infections of the Heart

    26. Infective Endocarditis

    27. Infectious Pericarditis

    28. Myocarditis

    29. Acute Rheumatic Fever

    30. Mediastinitis

    Section 4 - Central Nervous System Infections

    31. Bacterial Meningitis Beyond the Neonatal Period

    32. Parameningeal Infections.

    33. Fungal Meningitis

    34. Eosinophilic Meningitis

    35. Aseptic Meningitis and Viral Meningitis

    36. Encephalitis and Meningoencephalitis

    37. Parainfectious and Postinfectious Disorders of the Nervous System

    37a. Parainfectious and Postinfectious Demyelinating Disorders of the Central Nervous System

    37b. Infection-Associated Myelitis and Myelopathies of the Spinal Cord

    37c. Guillain-Barreì Syndrome

    Section 5 - Genitourinary Tract Infections

    38. Urethritis

    39. Cystitis and Pyelonephritis

    40. Renal Abscess

    41. Prostatitis

    42. Genital Infections

    Section 6 - Gastrointestinal Tract Infections

    43. Esophagitis

    44. Approach to Patients with Gastrointestinal Tract Infections and Food Poisoning

    45. Clostridium Difficile Infection

    46. Whipple Disease

    Section 7 - Liver Diseases

    47. Hepatitis

    48. Cholangitis and Cholecystitis

    49. Pyogenic Liver Abscess

    50. Reye Syndrome

    Section 8 - Other Intra-Abdominal Infections

    51. Appendicitis and Pelvic Abscess

    52. Pancreatitis

    53. Peritonitis and Intra-Abdominal Abscess

    54. Retroperitoneal Infections

    Section 9 - Musculoskeletal Infections

    55. Osteomyelitis

    56. Septic Arthritis

    57. Bacterial Myositis and Pyomyositis

    Section 10 - Skin Infections

    58. Cutaneous Manifestatiions of Systemic Infections

    59. Roseola Infantum (Exanthem Subitum)

    60. Skin Infections

    60a. Bacterial Skin Infections

    60b. Viral and Fungal Skin Infections

    Section 11 - Ocular Infectious Diseases

    61. Ocular Infections

    Section 12 - Systemic Infectious Diseases

    62. Bacteremia and Septic Shock

    63. Fever Without Source and Fever of Unknown Origin

    64. Toxic Shock Syndrome

    65. Pediatric Acute Respiratory Distress Syndrome

    Section 13 - Infections of the Fetus and Newborn

    66. Approach to Infections in the Fetus and Newborn

    Section 14 - Infections of the Compromised Host

    67. Primary Immunodeficiency Diseases

    68. The Febrile Neutropenic Patient

    69. Opportunistic Infections in Hematopoietic Stem Cell Transplantation

    70. Infections in Pediatric Heart Transplantation

    71. Infections in Pediatric Lung Transplantation

    72. Opportunistic Infections in Liver and Intestinal Transplantation

    73. Opportunistic Infections in Kidney Transplantation

    74. Infections Related to Prosthetic or Artificial Devices

    75. Infections Related to Craniofacial Surgical Procedures

    76. Infections in Burn Patients

    Section 15 - Unclassified Infectious Diseases

    77. Kawasaki Disease

    78. Chronic Fatigue Syndrome

    Part 3 - Infections with Specific Microorganisms

    Section 16 - Bacterial Infections

    79. Nomenclature for Aerobic and Anaerobic Bacteria

    Subsection 1 - Gram-Positive Cocci

    80. Staphylococcus aureus Infections (Coagulase-Positive Staphylococci)

    81. Coagulase-Negative Staphylococcal Infections

    82. Group A, Group C, and Group G Beta Hemolytic Streptococcal Infections

    83. Group B Streptococcal Infections

    84. Enterococcal and Viridans Streptococcal Infections

    85. Pneumococcal Infections

    86. Miscellaneous Gram-Positive Cocci

    Subsection 2 - Gram-Negative Cocci

    87. Moraxella catarrhalis

    88. Meningococcal Disease

    89. Gonococcal Infections

    Subsection 3 - Gram-Positive Bacilli

    90. Diphtheria

    91. Anthrax

    92. Bacillus Cereus and Other Bacillus Species

    93. Arcanobacterium haemolyticum

    94. Erysipelothrix rhusiopathiae

    95. Listeriosis

    96. Tuberculosis

    97. Other Mycobacteria

    98. Leprosy and Buruli Ulcer: The Major Cutaneous Mycobacterioses

    99. Nocardia

    100. Corynebacterium and Rhodococcus

    Subsection 4 - Gram-Negative Bacilli

    101. Citrobacter

    102. Enterobacter

    103. Extraintestinal Pathogenic Escherichia coli

    104. Diarrhea-Causing and Dysentery-Causing Escherichia coli

    105. Klebsiella

    106. Morganella morganii

    107. Proteus

    108. Providencia

    109. Shigella

    110. Serratia

    111. Salmonella

    112. Plague (Yersinia pestis)

    113. Other Yersinia Species.

    114. Miscellaneous Enterobacteriaceae

    115. Aeromonas

    116. Pasteurella multocida

    117. Cholera

    118. Vibrio parahaemolyticus

    119. Vibrio vulnificus

    120. Miscellaneous Non-Enterobacteriaceae Fermentative Bacilli

    121. Acinetobacter

    122. Achromobacter (Alcaligenes)

    123. Eikenella corrodens

    124. Elizabethkingia and Chryseobacterium Species

    125. Pseudomonas and Related Genera

    126. Stenotrophomonas (Xanthomonas) maltophilia

    Subsection 5 - Gram-Negative Coccobacilli

    127. Aggregatibacter species

    128. Brucellosis

    129. Pertussis and Other Bordetella Infections

    130. Klebsiella granulomatis

    131. Campylobacter jejuni

    132. Tularemia

    133. Haemophilus influenzae

    134. Other Haemophilus Species (Ducreyi, Haemolyticus, Influenzae Biogroup Aegyptius, Parahaemolyticus, and Parainfluenzae) and Aggregatibacter (Haemophilus) aphrophilus

    135. Helicobacter pylori

    136. Kingella kingae

    137. Legionnaires’ Disease, Pontiac Fever, and Related Illnesses

    138. Streptobacillus moniliformis (Rat-Bite Fever)

    139. Bartonella Infections

    Subsection 6 - Treponemataceae

    140. Lyme Disease

    141. Relapsing Fever

    142. Leptospirosis

    143. Spirillum minus (Rat-Bite Fever)

    144. Syphilis

    145. Nonvenereal Treponematoses

    Subsection 7 - Anaerobic Bacteria

    146. Clostridial Intoxication and Infection

    147. Infant Botulism

    148. Tetanus

    149. Actinomycosis

    150. Bacteroides, Fusobacterium, Prevotella, and Porphyromonas

    Section 17 - Viral Infections

    151. Classification and Nomenclature of Viruses

    Subsection 1 (DNA) - Parvoviridae

    152. Human Parvovirus B19

    153. Human Bocaviruses

    Subsection 2 (DNA) - Polyomaviridae

    154. Human Polyomaviruses

    155. Human Papillomaviruses

    Subsection 3 (DNA) - Adenoviridae

    156. Adenoviruses

    Subsection 4 (DNA) - Hepatoviridae

    157. Hepatitis B and D Viruses

    Subsection 5 (DNA) - Herpesviridae

    158. Herpes Simplex Viruses 1 and 2

    159. Cytomegalovirus

    160. Epstein-Barr Virus

    161. Human Herpesviruses 6A, 6B, 7, and 8

    162. Varicella-Zoster Virus

    Subsection 6 (DNA) - Poxviridae

    163. Smallpox (Variola Virus)

    164. Monkeypox and Other Poxviruses

    165. Mimiviruses

    Subsection 1 (RNA) - Picornaviridae

    166. Enteroviruses, Parechoviruses, and Saffold Viruses

    167. Rhinoviruses

    168. Hepatitis A Virus

    Subsection 2 (RNA) - Caliciviridae

    169. Calicivirus (Norovirus, Sapovirus, Vesivirus, Lagovirus, Nebovirus)

    170. Hepatitis E Virus

    Subsection 3 (RNA) - Reoviridae

    171. Reoviruses

    172. Orbiviruses, Coltiviruses, and Seadornaviruses

    173. Rotavirus

    Subsection 4 (RNA) - Togaviridae

    174. Rubella Virus

    175. Alphaviruses

    175a. Eastern Equine Encephalitis

    175b. Western Equine Encephalitis

    175c. Venezuelan Equine Encephalitis

    175d. Chikungunya

    175e. Ross River Virus Arthritis

    175f. Other Alphaviral Infections

    Subsection 5 - Flaviviridae

    176. Flaviviruses

    176a. St. Louis Encephalitis

    176b. West Nile Virus

    176c. Yellow Fever

    176d. Dengue, Dengue Hemorrhagic Fever, and Severe Dengue

    176e. Japanese Encephalitis

    176f. Murray Valley Encephalitis

    176g. Tick-Borne Encephalitis

    176h. Zika Virus Infections

    176i. Other Flaviral Infections

    177. Hepatitis C Virus

    Subsection 6 - Orthomyxoviridae

    178. Influenza Viruses

    Subsection 7 - Paramyxoviridae

    179. Parainfluenza Viruses

    180. Measles Virus

    181. Mumps Virus

    182. Respiratory Syncytial Virus

    183. Human Metapneumovirus

    Subsection 8 - Rhabdoviridae

    184. Rabies Virus

    Subsection 9 - Arenaviridae and Filoviridae

    185. Lymphocytic Choriomeningitis Virus

    186. Arenaviral Hemorrhagic Fevers

    187. Filoviral Hemorrhagic Fever: Marburg and Ebola Virus Fevers

    Subsection 10 - Coronaviridae and Toroviridae

    188. Human Coronaviruses, Including Middle East Respiratory Syndrome Coronavirus

    Subsection 11 - Bunyaviridae

    189. Hantaviruses.

    190. La Crosse Encephalitis and Other California Serogroup Viruses

    191. Other Bunyaviridae

    191a. Rift Valley Fever

    191b. Crimean-Congo Hemorrhagic Fever

    191c. Phlebotomus Fever (Sandfly Fever)

    191d. Oropouche Fever

    191e. Toscana Virus

    Subsection 12 - Retroviridae

    192. Human Retroviruses

    192a. Oncoviruses (Human T-Cell Lymphotropic Viruses) and Lentiviruses (Human Immunodeficiency Virus Type 2)

    192b. Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome

    Subsection 13 - Prion-Related Diseases

    193. Transmissible Spongiform Encephalopathies (Creutzfeldt-Jakob Disease, Gerstmann-Sträussler-Scheinker Disease, Kuru, Fatal Familial Insomnia, New Variant Creutzfeldt-Jakob Disease, Sporadic Fatal Insomnia)

    Section 18 - Chlamydia

    194. Chlamydia Infections

    Section 19 - Rickettsial Diseases

    195. Rickettsial and Ehrlichial Diseases .

    Section 20 - Mycoplasma

    196. Mycoplasma and Ureaplasma Infections

    Section 21 - Fungal Diseases

    197. Classification of Fungi

    198. Aspergillosis

    199. Blastomycosis

    200. Candidiasis

    201. Coccidioidomycosis

    202. Paracoccidioidomycosis

    203. Cryptococcosis

    204. Histoplasmosis

    205. Sporotrichosis

    206. Mucormycosis and Entomopthoramycosis

    207. Fusariosis and Scedosporiosis

    208. Miscellaneous Mycoses

    Section 22 - Parasitic Diseases

    209. Classification and Nomenclature of Human Parasites

    Subsection 1 - Protozoa

    210. Amebiasis

    211. Blastocystis hominis and Blastocystis spp. Infection

    212. Entamoeba coli Infection

    213. Giardiasis

    214. Dientamoeba fragilis Infections

    215. Trichomonas Infections

    216. Balantidium coli Infection

    217. Cryptosporidiosis

    218. Cyclosporiasis, Cystoisosporiasis, and Microsporidiosis

    219. Babesiosis

    220. Malaria

    221. Leishmaniasis

    222. Trypanosomiasis

    223. Naegleria, Acanthamoeba, and Balamuthia Infections

    224. Toxoplasmosis


    225. Pneumocystis Pneumonia

    Subsection 2 - Nematodes

    226. Parasitic Nematode Infections

    Subsection 3 - Cestodes

    227. Cestodes

    Subsection 4 - Trematodes

    228. Foodborne Trematodes

    229. Schistosomiasis

    Subsection 5 - Arthropods

    230. Arthropods

    Section 23 - Global Health

    231. Global Health

    232. International Travel Issues for Children

    233. Infectious Disease Considerations in International Adoptees and Refugees

    Part 4 - Therapeutics

    234. Antibiotic Resistance

    235. The Pharmacokinetic-Pharmacodynamic Interface: Determinants of Anti-Infective Drug Action and Efficacy in Pediatrics

    236. Antibacterial Therapeutic Agents

    237. Antimicrobial Prophylaxis

    238. Outpatient Intravenous Antimicrobial Therapy for Serious Infections

    239. Antiviral Agents

    240. Antifungal Agents

    241. Drugs for Parasitic Infections

    242. Immunomodulating Agents

    243. Probiotics

    Part 5 - Prevention of Infectious Diseases

    244. Health Care-Associated Infections

    245. Active Immunizing Agents

    246. Passive Immunization

    Section 24 - Other Preventative Considerations

    247. Public Health Aspects of Infectious Disease Control

    248. Infections in Out-of-Home Child Care

    249. Animal and Human Bites

    250. Bioterrorism

    Part 6 - Approach to the Laboratory Diagnosis of Infectious Diseases

    251. Bacterial Laboratory Diagnosis

    252. Fungal Laboratory Analysis: Specimen Collection, Direct Detection, and Culture

    253. Viral Laboratory Diagnosis

    254. Parasitic Laboratory Diagnosis



  • 1570.00 lei

    Includes a revised taxonomic outline for the Actinobacteria or the high G+C Gram positives is based upon the SILVA project as well as a description of greater than 200 genera in 49 families. Includes many medically and industrially important taxa.

  • 2,08900lei 1700.00 lei


    For four decades, physicians and other healthcare providers have trusted Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases to provide expert guidance on the diagnosis and treatment of these complex disorders. The 9th Edition continues the tradition of excellence with newly expanded chapters, increased global coverage, and regular updates to keep you at the forefront of this vitally important field. Meticulously updated by Drs. John E. Bennett, Raphael Dolin, and Martin J. Blaser, this comprehensive, two-volume masterwork puts the latest information on challenging infectious diseases at your fingertips.

    Table Of Contents:

    I Basic Principles in the Diagnosis and Management of Infectious Diseases
    1 A Molecular Perspective of Microbial Pathogenicity
    2 The Human Microbiome of Local Body Sites and Their Unique Biology
    3 Prebiotics, Probiotics, and Synbiotics
    4 Innate (General or Nonspecific) Host Defense Mechanisms
    5 Adaptive Immunity: Antibodies and Immunodeficiencies
    6 Cell-Mediated Defense Against Infection
    7 Mucosal Immunity
    8 Granulocytic Phagocytes
    9 Complement and Deficiencies
    10 Human Genetics and Infection
    11 Nutrition, Immunity, and Infection
    12 Evaluation of the Patient With Suspected Immunodeficiency
    13 Applied Epidemiology for the Infectious Diseases Physician
    14 Emerging and Reemerging Infectious Disease Threats
    15 Bioterrorism: An Overview
    16 The Clinician and the Microbiology Laboratory: Test Ordering, Specimen Collection, and Result Interpretation
    17 Principles of Antiinfective Therapy
    18 Molecular Mechanisms of Antibiotic Resistance in Bacteria
    19 Pharmacokinetics and Pharmacodynamics of Antiinfective Agents
    20 Penicillins and ß-Lactamase Inhibitors
    21 Cephalosporins
    22 Ertapenem, Imipenem, Meropenem, Doripenem, and Aztreonam
    23 Antibiotic Allergy
    24 Fusidic Acid
    25 Aminoglycosides
    26 Tetracyclines, Glycylcyclines, and Chloramphenicol
    27 Rifamycins
    28 Metronidazole
    29 Macrolides and Clindamycin
    30 Glycopeptides (Vancomycin and Teicoplanin) and Lipoglycopeptides (Telavancin, Oritavancin, and Dalbavancin)
    31 Daptomycin and Quinupristin-Dalfopristin
    32 Polymyxins (Polymyxin B and Colistin)
    33 Linezolid, Tedizolid, and Other Oxazolidinones
    34 Sulfonamides and Trimethoprim; Trimethoprim-Sulfamethoxazole
    35 Quinolones
    36 Unique Antibacterial Agents
    37 Urinary Tract Agents: Nitrofurantoin, Fosfomycin, and Methenamine
    38 Topical Antibacterials
    39 Antimycobacterial Agents
    40A Antifungal Agents: Amphotericin B
    40B Antifungal Drugs: Azoles
    40C Antifungal Drugs: Echinocandins
    40D Antifungal Drugs: Flucytosine
    41 Antimalarial Drugs
    42 Drugs for Protozoal Infections Other Than Malaria
    43 Drugs for Helminths
    44 Antiviral Agents: General Principles
    45 Antiviral Drugs for Influenza and Other Respiratory Virus Infections
    46 Antivirals Against Herpesviruses
    47 Antiviral Drugs Against Hepatitis Viruses
    48 Miscellaneous Antiviral Agents (Interferons, Tecovirimat, Imiquimod, Pocapavir, Pleconaril)
    49 Immunomodulators
    50 Hyperbaric Oxygen
    51 Antimicrobial Stewardship
    52 Designing and Interpreting Clinical Studies in Infectious Diseases
    53 Outpatient Parenteral Antimicrobial Therapy
    54 Tables of Antiinfective Agent Pharmacology
    II Major Clinical Syndromes
    55 Temperature Regulation and the Pathogenesis of Fever
    56 Fever of Unknown Origin
    57 The Acutely Ill Patient With Fever and Rash
    58 The Common Cold
    59 Pharyngitis
    60 Acute Laryngitis
    61 Otitis Externa, Otitis Media, and Mastoiditis
    62 Sinusitis
    63 Epiglottitis
    64 Infections of the Oral Cavity, Neck, and Head
    65 Acute Bronchitis
    66 Acute Exacerbations of Chronic Obstructive Pulmonary Disease
    67 Acute Pneumonia
    68 Pleural Effusion and Empyema
    69 Bacterial Lung Abscess
    70 Chronic Pneumonia
    71 Cystic Fibrosis
    72 Urinary Tract Infections
    73 Sepsis and Septic Shock
    74 Peritonitis and Intraperitoneal Abscesses
    75 Infections of the Liver and Biliary System (Liver Abscess, Cholangitis, Cholecystitis)
    76 Pancreatic Infection
    77 Splenic Abscess
    78 Appendicitis
    79 Diverticulitis and Neutropenic Enterocolitis
    80 Endocarditis and Intravascular Infections
    81 Prosthetic Valve Endocarditis
    82 Infections of Nonvalvular Cardiovascular Devices
    83 Prevention of Infective Endocarditis
    84 Myocarditis and Pericarditis
    85 Mediastinitis
    86 Approach to the Patient With Central Nervous System Infection
    87 Acute Meningitis
    88 Chronic Meningitis
    89 Encephalitis
    90 Brain Abscess
    91 Subdural Empyema, Epidural Abscess, and Suppurative Intracranial Thrombophlebitis
    92 Cerebrospinal Fluid Shunt and Drain Infections
    93 Cellulitis, Necrotizing Fasciitis, and Subcutaneous Tissue Infections
    94 Myositis and Myonecrosis
    95 Lymphadenitis and Lymphangitis
    96 Syndromes of Enteric Infection
    97 Esophagitis
    98 Diarrhea With Little or No Fever
    99 Acute Dysentery Syndromes (Diarrhea With Fever)
    100 Typhoid Fever, Paratyphoid Fever, and Typhoidal Fevers
    101 Foodborne Disease
    102 Tropical Sprue and Environmental Enteric Dysfunction
    103 Infectious Arthritis of Native Joints
    104 Osteomyelitis
    105 Orthopedic Implant-Associated Infections
    106 Genital Skin and Mucous Membrane Lesions
    107 Urethritis
    108 Vulvovaginitis and Cervicitis
    109 Infections of the Female Pelvis
    110 Prostatitis, Epididymitis, and Orchitis
    111 Introduction to Eye Infections
    112 Microbial Conjunctivitis
    113 Microbial Keratitis
    114 Endophthalmitis
    115 Infectious Causes of Uveitis
    116 Periocular Infections
    117 Viral Hepatitis
    118 Global Perspectives on Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome
    119 Epidemiology and Prevention of AIDS and HIV Infection, Including Preexposure Prophylaxis and HIV Vaccine Development
    120 Diagnosis of Human Immunodeficiency Virus Infection
    121 The Immunology of Human Immunodeficiency Virus Infection
    122 General Clinical Manifestations of Human Immunodeficiency Virus Infection (Including Acute Retroviral Syndrome and Oral, Cutaneous, Renal, Ocular, Metabolic, and Cardiac Diseases)
    123 Pulmonary Manifestations of Human Immunodeficiency Virus Infection
    124 Gastrointestinal, Hepatobiliary, and Pancreatic Manifestations of Human Immunodeficiency Virus Infection
    125 Neurologic Diseases Caused by Human Immunodeficiency Virus Type 1 and Opportunistic Infections
    126 Human Immunodeficiency Virus Infection in Women
    127 Pediatric Human Immunodeficiency Virus Infection
    128 Antiretroviral Therapy for Human Immunodeficiency Virus Infection
    129 Management of Opportunistic Infections Associated With Human Immunodeficiency Virus Infection
    130 Chronic Fatigue Syndrome (Systemic Exertion Intolerance Disease)
    III Infectious Diseases and Their Etiologic Agents
    131 Biology of Viruses and Viral Diseases
    132 Orthopoxviruses Vaccinia (Smallpox Vaccine), Variola (Smallpox), Monkeypox, and Cowpox
    133 Other Poxviruses That Infect Humans: Parapoxviruses (Including Orf Virus), Molluscum Contagiosum, and Yatapoxviruses
    134 Introduction to Herpesviridae
    135 Herpes Simplex Virus
    136 Chickenpox and Herpes Zoster (Varicella-Zoster Virus)
    137 Cytomegalovirus
    138 Epstein-Barr Virus (Infectious Mononucleosis, Epstein-Barr Virus-Associated Malignant Diseases, and Other Diseases)
    139 Human Herpesvirus Types 6 and 7 (Exanthem Subitum)
    140 Kaposi Sarcoma-Associated Herpesvirus (Human Herpesvirus 8)
    141 Herpes B Virus
    142 Adenoviruses
    143 Papillomaviruses
    144 JC, BK, and Other Polyomaviruses: Progressive Multifocal Leukoencephalopathy (PML)
    145 Hepatitis B Virus
    146 Hepatitis Delta Virus
    147 Human Parvoviruses, Including Parvovirus B19V and Human Bocaparvoviruses
    148 Orthoreoviruses and Orbiviruses
    149 Coltiviruses (Colorado Tick Fever Virus) and Seadornaviruses
    150 Rotaviruses
    151 Alphaviruses (Chikungunya, Eastern Equine Encephalitis)
    152 Rubella Virus (German Measles)
    153 Flaviviruses (Dengue, Yellow Fever, Japanese Encephalitis, West Nile Encephalitis, Usutu Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis, Kyasanur Forest Disease, Alkhurma Hemorrhagic Fever, Zika)
    154 Hepatitis C
    155 Coronaviruses, Including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS)
    156 Parainfluenza Viruses
    157 Mumps Virus
    158 Respiratory Syncytial Virus
    159 Human Metapneumovirus
    160 Measles Virus (Rubeola)
    161 Zoonotic Paramyxoviruses: Nipah, Hendra, and Menangle Viruses
    162 Vesicular Stomatitis Virus and Related Vesiculoviruses (Chandipura Virus)
    163 Rabies (Rhabdoviruses)
    164 Marburg and Ebola Virus Hemorrhagic Fevers
    165 Influenza Viruses, Including Avian Influenza and Swine Influenza
    166 California Encephalitis, Hantavirus Pulmonary Syndrome, Hantavirus Hemorrhagic Fever With Renal Syndrome, and Bunyavirus Hemorrhagic Fevers
    167 Lymphocytic Choriomeningitis Virus, Lassa Virus, and the South American Hemorrhagic Fevers (Arenaviruses)
    168 Human T-Cell Leukemia Viruses (HTLV-1, HTLV-2)
    169 Human Immunodeficiency Viruses
    170 Introduction to the Human Enteroviruses and Parechoviruses
    171 Poliovirus
    172 Coxsackieviruses, Echoviruses, and Numbered Enteroviruses (EV-A71, EVD-68, EVD-70)
    173 Parechoviruses
    174 Hepatitis A Virus
    175 Rhinovirus
    176 Noroviruses and Sapoviruses (Caliciviruses)
    177 Astroviruses and Picobirnaviruses
    178 Hepatitis E Virus
    179 Prions and Prion Disease of the Central Nervous System (Transmissible Neurodegenerative Diseases)
    180 Chlamydia trachomatis (Trachoma and Urogenital Infections)
    181 Psittacosis (Due to Chlamydia psittaci)
    182 Chlamydia pneumoniae
    183 Mycoplasma pneumoniae and Atypical Pneumonia
    184 Genital Mycoplasmas: Mycoplasma genitalium, Mycoplasma hominis, and Ureaplasma Species
    185 Introduction to Rickettsioses, Ehrlichioses, and Anaplasmoses
    186 Rickettsia rickettsii and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers)
    187 Rickettsia akari (Rickettsialpox)
    188 Coxiella burnetii (Q Fever)
    189 Rickettsia prowazekii (Epidemic or Louse-Borne Typhus)
    190 Rickettsia typhi (Murine Typhus)
    191 Orientia tsutsugamushi (Scrub Typhus)
    192 Ehrlichia chaffeensis (Human Monocytotropic Ehrlichiosis), Anaplasma phagocytophilum (Human Granulocytotropic Anaplasmosis), and Other Anaplasmataceae
    193 Introduction to Bacteria and Bacterial Diseases
    194 Staphylococcus aureus (Including Staphylococcal Toxic Shock Syndrome)
    195 Staphylococcus epidermidis and Other Coagulase-Negative Staphylococci
    196 Classification of Streptococci
    197 Streptococcus pyogenes
    198 Nonsuppurative Poststreptococcal Sequelae: Rheumatic Fever and Glomerulonephritis
    199 Streptococcus pneumoniae
    200 Enterococcus Species, Streptococcus gallolyticus Group, and Leuconostoc Species
    201 Streptococcus agalactiae (Group B Streptococci)
    202 Viridans Streptococci, Nutritionally Variant Streptococci, and Groups C and G Streptococci
    203 Streptococcus anginosus Group
    204 Corynebacterium diphtheriae (Diphtheria)
    205 Other Coryneform Bacteria, Arcanobacterium haemolyticum, and Rhodococci
    206 Listeria monocytogenes
    207 Bacillus anthracis (Anthrax)
    208 Bacillus Species and Related Genera Other Than Bacillus anthracis
    209 Erysipelothrix Rhusiopathiae
    210 Whipple Disease
    211 Neisseria meningitidis
    212 Neisseria gonorrhoeae (Gonorrhea)
    213 Moraxella catarrhalis, Kingella, and Other Gram-Negative Cocci
    214 Vibrio cholerae
    215 Other Pathogenic Vibrios
    216 Campylobacter jejuni and Related Species
    217 Helicobacter pylori and Other Gastric Helicobacter Species
    218 Enterobacteriaceae
    219 Pseudomonas aeruginosa and Other Pseudomonas Species
    220 Stenotrophomonas maltophilia and Burkholderia cepacia Complex
    221 Burkholderia pseudomallei and Burkholderia mallei: Melioidosis and Glanders
    222 Acinetobacter Species
    223 Salmonella Species
    224 Bacillary Dysentery: Shigella and Enteroinvasive Escherichia coli
    225 Haemophilus Species, Including H. influenzae and H. ducreyi (Chancroid)
    226 Brucellosis (Brucella Species)
    227 Francisella tularensis (Tularemia)
    228 Pasteurella Species
    229A Plague (Yersinia pestis)
    229B Yersinia enterocolitica and Yersinia pseudotuberculosis
    230 Bordetella pertussis
    231 Rat-Bite Fever: Streptobacillus moniliformis and Spirillum minus
    232 Legionnaires’ Disease and Pontiac Fever
    233 Capnocytophaga
    234 Bartonella, Including Cat-Scratch Disease
    235 Klebsiella granulomatis (Donovanosis, Granuloma Inguinale)
    236 Other Gram-Negative and Gram-Variable Bacilli
    237 Syphilis (Treponema pallidum)
    238 Endemic Treponematoses
    239 Leptospira Species (Leptospirosis)
    240 Relapsing Fever Caused by Borrelia Species
    241 Lyme Disease (Lyme Borreliosis) Due to Borrelia burgdorferi
    242 Anaerobic Infections: General Concepts
    243 Clostridioides difficile (Formerly Clostridium difficile) Infection
    244 Tetanus (Clostridium tetani)
    245 Botulism (Clostridium botulinum)
    246 Diseases Caused by Clostridium
    247 Bacteroides, Prevotella, Porphyromonas, and Fusobacterium Species (and Other Medically Important Anaerobic Gram-Negative Bacilli)
    248 Anaerobic Cocci and Anaerobic Gram-Positive Nonsporulating Bacilli
    249 Mycobacterium tuberculosis
    250 Leprosy (Mycobacterium leprae)
    251 Mycobacterium avium Complex
    252 Infections Caused by Nontuberculous Mycobacteria Other Than Mycobacterium avium Complex
    253 Nocardia Species
    254 Agents of Actinomycosis
    255 Introduction to Mycoses
    256 Candida Species
    257 Aspergillus Species
    258 Agents of Mucormycosis and Entomophthoramycosis
    259 Sporothrix schenckii
    260 Agents of Chromoblastomycosis
    261 Agents of Mycetoma
    262 Cryptococcosis (Cryptococcus neoformans and Cryptococcus gattii)
    263 Histoplasma capsulatum (Histoplasmosis)
    264 Blastomycosis
    265 Coccidioidomycosis (Coccidioides Species)
    266 Dermatophytosis (Ringworm) and Other Superficial Mycoses
    267 Paracoccidioidomycosis
    268 Uncommon Fungi and Related Species
    269 Pneumocystis Species
    270 Microsporidiosis
    271 Introduction to Protozoal Diseases
    272 Entamoeba Species, Including Amebic Colitis and Liver Abscess
    273 Free-Living Amebae
    274 Malaria (Plasmodium Species)
    275 Leishmania Species: Visceral (Kala-Azar), Cutaneous, and Mucosal Leishmaniasis
    276 Trypanosoma Species (American Trypanosomiasis, Chagas Disease): Biology of Trypanosomes
    277 Agents of African Trypanosomiasis (Sleeping Sickness)
    278 Toxoplasma gondii
    279 Giardia lamblia
    280 Trichomonas vaginalis
    281 Babesia Species
    282 Cryptosporidiosis (Cryptosporidium Species)
    283 Cyclospora cayetanensis, Cystoisospora belli, Sarcocystis Species, Balantidium coli, and Blastocystis Species
    284 Human Illness Associated With Harmful Algal Blooms
    285 Introduction to Helminth Infections
    286 Intestinal Nematodes (Roundworms)
    287 Tissue Nematodes, Including Trichinellosis, Dracunculiasis, Filariasis, Loiasis, and Onchocerciasis
    288 Trematodes (Schistosomes and Liver, Intestinal, and Lung Flukes)
    289 Tapeworms (Cestodes)
    290 Visceral Larva Migrans and Other Uncommon Helminth Infections
    291 Introduction to Ectoparasitic Diseases
    292 Lice (Pediculosis)
    293 Scabies
    294 Myiasis and Tungiasis
    295 Mites, Including Chiggers
    296 Ticks, Including Tick Paralysis
    297 Kawasaki Disease
    IV Special Problems
    298 Infection Prevention and Control in the Health Care Setting
    299 Disinfection, Sterilization, and Control of Hospital Waste
    300 Infections Caused by Percutaneous Intravascular Devices
    301 Nosocomial Pneumonia
    302 Health Care-Associated Urinary Tract Infections
    303 Health Care-Acquired Hepatitis
    304 Transfusion- and Transplantation-Transmitted Infections
    305 Infections in the Immunocompromised Host: General Principles
    306 Prophylaxis and Empirical Therapy of Infection in Cancer Patients
    307 Infections in Recipients of Hematopoietic Stem Cell Transplants
    308 Infections in Solid-Organ Transplant Recipients
    309 Infections in Patients With Spinal Cord Injury
    310 nfections in Older Adults
    311 Infections in Asplenic Patients
    312 Infections in Injection Drug Users
    313 Surgical Site Infections and Antimicrobial Prophylaxis
    314 Burns
    315 Bites
    316 Immunization
    317 Zoonoses
    318 Protection of Travelers
    319 Infections in Returning Travelers