pe pagina
  • 18000lei 155.00 lei



    For over half a century Davidson’s Principles and Practice of Medicine has informed and educated students, doctors and other health professionals all over the world, providing a comprehensive account of the practice of medicine. Davidson’s Essentials of Medicine provides the core content of the main textbook in a condensed format which will be invaluable whenever you are on the move - whether commuting, travelling between training sites, or on electives.


    • This book provides a distillation of the core information required for clinical studies in medicine. While retaining the acclaimed readability of the main textbook it presents the key information in a format more appropriate for practical clinical work.
    • The scope of the contents was carefully selected by a team of junior doctors, emphasising only the topics that will be essential for clinical studies.
    • The text draws directly on the depth and breadth of experience of the Davidson’s authors and its International Advisory Board.

    New To This Edition:

    • Updated to include key changes and new illustrations included in Davidson’s Principles and Practice of Medicine.
    • New chapters on Acute Medicine and Ophthalmology

    Table Of Contents:

    • Poisons, toxicology and envenomation
    • Acute medicine and critical illness
    • Infectious diseases
    • Clinical biochemistry and metabolism
    • Kidney and urinary tract disease
    • Cardiovascular disease
    • Respiratory disease
    • Endocrine disease
    • Nutrition and disease
    • Diabetes mellitus
    • Alimentary tract and pancreatic disease
    • Liver and biliary tract disease
    • Blood disease
    • Rheumatology and bone disease
    • Neurological disease
    • Medical ophthalmology
    • Skin disease
    • Ageing and disease
    • Reference ranges


  • 19000lei 160.00 lei

    Now in its tenth edition, the Oxford Handbook of Clinical Medicine has been fully revised, with five new authors on the writing team bringing content fresh from the bedside.

    Space has been breathed into the design, with more core material at your fingertips in quick-reference lists and flow diagrams, and key references have been honed to the most up-to-date and relevant. Each page has been updated to reflect the latest changes in practice and best management, and the chapters on gastroenterology, history and examination, infectious disease, neurology, and radiology have been extensively revised.

    Unique among medical texts, the Oxford Handbook of Clinical Medicine is a complete and concise guide to the core areas of medicine that also encourages thinking about the world from the patient's perspective, offering a holistic, patient-centred approach.

    Loved and trusted by millions for over three decades, the Oxford Handbook of Clinical Medicine continues to be a truly indispensable companion for the practice of modern medicine.

  • 165.00 lei

    As per the directives from Ministry of Health and Family Welfare, Government of India, the National Board of Examinations (NBE) would be conducting a computer-based multiple choice questions (MCQs) examination. Candidates appearing for DM (Endocrinology) Entrance Examinations would be expected to answer 40% questions from the feeder specialty and 60% questions would be in Endocrinology. This book is aimed to give students an idea of the kind of questions that they might expect/anticipate in the examinations. Based on the pattern of NEET DM Endocrinology entrance examination. Presented in an easy to read layout. Divided into 25 chapters as per the pattern. Concise answers and explanations. References from standard textbooks. Useful diagrams and tables are incorporated.

  • 180.00 lei

    A full-color case-based review of the essentials of pathophysiology covering all major organs and systems

    The goal of this trusted text is to introduce you to clinical medicine by reviewing the pathophysiologic basis of 132 diseases (and associated signs and symptoms) commonly encountered in medical practice. The authors, all experts in their respective fields, have provided a concise review of relevant normal structure and function of each body system, followed by a description of the pathophysiologic mechanisms that underlie several common diseases related to that system. The accessible presentation features high-quality full-color illustrations, and numerous tables and diagrams.

    Each chapter of Pathophysiology of Disease concludes with a collection of case studies and questions designed to test your understanding of the pathophysiology of each clinical entity discussed. These case studies allow you to apply your knowledge to specific clinical situations. Detailed answers to each case study question are provided at the end of the book. 

    This unique interweaving of physiological and pathological concepts will put you on the path toward thinking about signs and symptoms in terms of their pathophysiologic basis, giving you an understanding of the "why" behind illness and treatment.


    •Twelve additional case studies, bringing the total to 132, one for each of the clinical entities discussed in the book’s 24 chapters
    •More than 2/3 of the chapters are enhanced and refreshed by the input of new contributors
    •Totally revised chapter on neoplasia
    •New chapter sections on urticaria, spinocerebellar ataxia, idiopathic pulmonary fibrosis, and spondyloarthropathies
    •New tables summarizing adverse prognostic signs in acute pancreatitis, genetic syndromes associated with pancreatic cancer, and causes of end-stage renal disease
    •New diagnosis and etiologic classification of diabetes mellitus, and review of mechanisms of newest pharmacologic agents for its treatment
    •Updates on fine-needle aspiration biopsy of thyroid nodules, and thyroid disorders in pregnancy
    •Updated references throughout the book


    Table of Contents:

    Chapter 1: Introduction

    Chapter 2: Genetic Disease

    Chapter 3: Disorders of the Immune System

    Chapter 4: Infectious Diseases

    Chapter 5: Neoplasia

    Chapter 6: Blood Disorders

    Chapter 7: Nervous System Disorders

    Chapter 8: Diseases of the Skin

    Chapter 9: Pulmonary Disease

    Chapter 10: Cardiovascular Disorders: Heart Disease

    Chapter 11: Cardiovascular Disorders: Vascular Disease

    Chapter 12: Disorders of the Adrenal Medulla

    Chapter 13: Gastrointestinal Disease

    Chapter 14: Liver Disease

    Chapter 15: Disorders of the Exocrine Pancreas

    Chapter 16: Renal Disease

    Chapter 17: Disorders of the Parathyroids & Calcium and Phosphorus Metabolism

    Chapter 18: Disorders of the Endocrine Pancreas

    Chapter 19: Disorders of the Hypothalamus & Pituitary Gland

    Chapter 20: Thyroid Disease

    Chapter 21: Disorders of the Adrenal Cortex

    Chapter 22: Disorders of the Female Reproductive Tract

    Chapter 23: Disorders of the Male Reproductive Tract

    Chapter 24: Inflammatory Rheumatic Diseases


  • Internal Medicine
    La comanda in aproximativ 4 saptamani
    185.00 lei

    Internal or general medicine is the medical specialty dealing with the prevention, diagnosis and treatment of adult diseases. This second edition provides clinicians and trainees with a complete guide to internal medicine. Divided into 28 sections, the first part of the book is dedicated to the diagnosis and management of cardiac conditions. The second part covers respiratory and pulmonary disorders, gastrointestinal diseases, neurologic disorders, renal conditions and endocrine disorders. The book has been fully revised with new topics added to provide the latest advances in the field. Each chapter examines the pathophysiology and techniques for accurate diagnosis and appropriate therapy. Authored by a recognised, Ottawa-based expert in the field, the new edition features clinical photographs, illustrations and tables to enhance learning. Key points Comprehensive guide to the latest advances in internal medicine Fully revised, second edition covering numerous disorders in different systems of the body Authored by recognised Ottawa-based expert in the field Previous edition (9780812116021) published in 1994

  • 185.00 lei

    Tuberculosis (TB) is a bacterial infection spread through inhaling tiny droplets from the coughs or sneezes of an infected person. It mainly affects the lungs, but it can affect any part of the body, including the abdomen, glands, bones and nervous system (NHS Choices). Part of the Clinical Focus series, this book is a comprehensive guide to the diagnosis and treatment of this serious condition. Beginning with an introduction to the microbiology and epidemiology of the disease, the following chapters provide in depth coverage of the clinical assessment, diagnostic techniques, and management options for different strains of tuberculosis. Each chapter is highly illustrated with tables and images to enhance the detailed text. Edited by recognised specialists from Belgrade, Serbia, the new volume in this series includes contributions from highly experienced clinicians throughout the world. Key Points Comprehensive guide to diagnosis and treatment of tuberculosis Part of the Clinical Focus series Highly illustrated with tables and images Internationally recognised editor and author team

  • 19000lei 185.00 lei

    Fully updated and revised for its second edition, the Oxford Handbook of Clinical Examination and Practical Skills is the only truly comprehensive pocket guide to all aspects of history taking, physical examination, practical procedures, data interpretation, and communication skills. Packed with expert knowledge and practical guidance it gives realistic advice on coping with common situations. The handbook is structured to allow rapid reference of key information, and to aid understanding with concise and practical clinical guidance. Full colour throughout, it includes over 140 detailed photographs and diagrams of all common examination skills to show you exactly what you need to do and the theory, practice and complications for each. More photos have been included, with over half completely new and specially produced for this edition. Each system chapter covers applied anatomy, history, examination, and the presentation of common and important disorders. Data interpretation covers the basics of x-rays, ECGs and other key areas. A new chapter on the eyes is included along with the sections on body language and non-verbal communication, and the section on practical procedures has been expanded. This handbook will help to ensure you have the confidence and skill to carry out an 'A' grade examination every time.

  • 19000lei 185.00 lei

     Now revised for its third edition, the Oxford Handbook of Clinical Diagnosis provides a concise and practical summary of the reasoning processes behind clear and confident diagnosis. The handbook is set out systematically with symptoms and signs through each specialty, and includes a detailed description of the basis of logical evidence-based differential diagnosis. 
    This new edition has been updated with clearer diagrams and brand new images. Including rarer diagnoses alongside the common conditions, and vital information about longer-term management alongside the initial treatments, this handbook will ensure your excellence and confidence no matter what signs and symptoms your patient presents with. Providing practical help when dealing with problems outside your area of expertise or with unforeseen situations, you can be sure that this handbook will be your perfect companion to clear and confident diagnoses throughout your medical career.

  • Leg Ulcers
    La comanda in aproximativ 4 saptamani
    22500lei 200.00 lei

  • 23500lei 200.00 lei



    Understand and correctly use all the latest terminology in today’s ever-evolving medical field with the 32nd Edition of the comprehensive, highly respected Dorland’s Illustrated Medical Dictionary! Thoroughly updated, this user-friendly reference—trusted for more than a century by healthcare personnel at every professional level—allows you to grasp the meanings of all medical terms in current usage. It delivers more total entries than in any other dictionary of its kind, including several thousand new words, as well as 500 new illustrations to aid your understanding. Plus, with the bonus CD-ROM, you can listen to 35,000 audio pronunciations! And you can consult the dictionary anytime, anywhere online with free access to Easily stay up with the changing terminology in your field by depending on Dorland’s—the most reliable medical dictionary available today!


    Enhance your understanding of all the current medical terminology in your field by relying on the most comprehensive and highly respected medical dictionary, bringing you more than 120,000 well-defined entries and 1500 clear illustrations.

    Listen to 35,000 audio pronunciations.

    Search on the Internet anytime, anywhere for all of the language integral to contemporary medicine.

    New To This Edition:

    Make sure you’re familiar with the very latest medical terms used today with more than 5,500 new entries drawn from current sources.

    Complement your understanding of new words and ideas in medicine with 500 new illustrations

    Get more information in a smaller amount of space as the revised entry format includes related parts of speech.


  • Doctor's Pocket Companion
    La comanda in aproximativ 4 saptamani
    215.00 lei

    A comprehensive book for all kinds of modern medicine doctors, especially for those who work as generalists (General Medicine, Family Medicine) and those who use clinical skill optimally in medical practice. Aims to enrich basic skills of diagnosis and management. Based on problem-oriented approach. Topics are presented systematically for quick reference. Makes the clinical diagnosis easy with less of investigation. Focuses on wider spectrum of readers. Companion reference book for Interns, General Practitioners, Family Doctors, General Physicians and healthcare providers with a holistic attitude toward patient care.

  • 220.00 lei


    Coordonatorii editiei in limba romana: Prof. Dr. Corin Badiu si Prof. Dr. Cristian Baicus

    Unic printre textele medicale, Manualul Oxford de Medicina Clinica (ediția a zecea) reprezinta un material complet si concis pentru specializarile principale ale medicinei si ofera o abordare holistica, centrata pe pacient. Editia a zecea prezinta informatii-cheie actualizate, iar capitolele privind gastroenterologia, bolile infectioase, neurologia si radiologia au fost complet revizuite. Abordarea tematica se suprapune cu evaluarea clasica a fiecarui caz: anamneza si examenul obiectiv, apoi descrierea patologiei pe aparate si sisteme, cu exemple, scheme, tabele si imagini, care aduc valoare practicii medicale.

    Apreciat de medici de peste trei decenii, Manualul Oxford de Medicina Clinica continua sa fie un ghid cu adevarat indispensabil pentru practica medicinei moderne.

     Prefata la editia in limba romana

    „Pornind de la prima pagina, medicul cu experienta sau in formare descopera un nou prieten: o carte sintetizată, bine organizată tematic, atractiva, care expune intr-o combinatie unica elementele de detaliu privind diagnosticul si tratamentul. Sistematizata in 19 capitole, manualul porneste de la un scurt istoric filozofic al domeniului, luand in discutie repere majore ale filozofiei medicale, dar si aspecte etice importante. Principiile medicinei bazate pe dovezi si ale statisticii medicale fac parte din acelasi capitol initial.

    Abordarea tematica se suprapune cu evaluarea clasica a fiecarui caz: anamneză si examenul obiectiv, apoi descrierea patologiei pe aparate si sisteme, cu exemple, scheme, tabele si imagini, care aduc valoare practicii medicale.

    Temele speciale sunt evidentiate prin casete specifice, la care se face trimitere ori de cate ori este necesar. Realizate excelent din punct de vedere grafic, imaginile sunt foarte sugestive, intregind armonios informatia din text si tabele. Manualul include informatii de ultima ora, foarte bine structurate in tabele si algoritmi, care ofera practicianului un sprijin permanent in decizia medicala. Din loc in loc se regasesc istorioare din viata curenta a practicianului sau repere istorice ale domeniului, care fac lectura captivanta.

    Traducerea carții Oxford Handbook of Clinical Medicine a beneficiat de implicarea unui grup de specialisti entuziasti, care au adaptat informatiile la terminologia clasica romaneasca, realizand un text fluent, atractiv si precis. Multumim tuturor celor care au dedicat timp si energie pentru a face posibila aparitia acestui manual in limba romana.

    Sunt convins ca acest volum reprezinta un instrument util atat pentru medicul cu experiența, cat si pentru cel aflat la inceputul carierei, fiecare gasind deopotrivă un prieten de nadejde în Manualul Oxford de Medicina Clinica.

    Va dorim lectura placuta!

    Prof. Dr. Corin Badiu”


    Conținutul fiecarui capitol este detaliat pe pagina dedicata acestuia.

    Prefata la editia in limba romană si la editia a X-a vi

    Mulțumiri vii

    Simboluri si abrevieri viii

    Cugetari medicale 0

    Istoric si examinare 40

    Patologie cardiovasculara 110

    Pneumologie 182

    Endocrinologie 224

    Gastroenterologie 266

    Nefrologie 324

    Hematologie 364

    Boli infectioase 424

    10 Neurologie 506

    11 Oncologie si ingrijiri paliative 580

    12 Reumatologie 606

    13 Chirurgie 636

    14 Biochimie clinică 742

    15 Sindroame eponime 774

    16 Radiologie 800

    17 Intervale de referintă si alte aspecte 832

    18 Proceduri practice 840

    19 Urgente 860

    20 Referinte 936

    Scorul de avertizare timpurie 952

    Stopul cardiac 954


  • 230.00 lei

    50 Studies Every Internist Should Know presents key studies that shape today's practice of internal medicine. Selected using a rigorous methodology, the studies cover topics including: preventative medicine, endocrinology, hematology and oncology, musculoskeletal diseases, nephrology, gastroenterology, infectious diseases, cardiology, pulmonology, geriatrics and palliative care, and mental health. For each study, a concise summary is presented with an emphasis on the results and limitations of the study, and its implications for practice. An illustrative clinical case concludes each review, followed by brief information on other relevant studies. This book is a must-read for health care professionals and anyone who wants to learn more about the data behind clinical practice.

  • 27500lei 230.00 lei



    This classic textbook aims to assist clinicians develop the consultation skills required to elicit a clear history, and the practical skills needed to detect clinical signs of disease. Where possible, the physical basis of clinical signs is explained to aid understanding. Formulation of a differential diagnosis from the information gained is introduced, and the logical initial investigations are included for each system.


    The first part of the book addresses the general principles of good interaction with patients, from the basics of taking a history and examining, to the use of pattern recognition to identify spot diagnoses.

    The second part documents the relevant history, examination and investigations for all the major body systems.

    The third part illustrates the application of these skills to specific clinical situations.

    The final part covers preparation for assessments of clinical skills and the use of these skills in everyday practice.

    The book has accompanying videos demonstrating many of the key clinical examination routines as set out in the book.

    New To This Edition:

    A new editorial team has undertaken a substantial review of the book’s contents and with the help of many new authors has radically revised the order and approach of the text.

    Several new chapters have been created including a chapter on patients with mental disorders; a chapter covering the approach to a deteriorating patient; a chapter on assessment of patients towards the end of life and two new chapters on applying the key clinical skills during assessments and in practice.

    The structure of the text has been rationalised with careful use of boxes, tables and figures to set out the concepts for maximum clarity.


  • 38100lei 260.00 lei

    CURRENT Medical Diagnosis & Treatment is the most comprehensive, reliable, and timely reference available to answer common questions that arise in everyday clinical practice. Readers will find authoritative, evidence-based coverage of more than 1,000 diseases and disorders along with a concise, yet thorough synopsis of diagnosis and treatment.


    Written in a clear, easy-to-read style, this trusted classic covers all aspects of outpatient and inpatient care and includes discussion of new developments and breakthroughs in medicine. Presented in full colour, CMDT covers every aspect of general medicine, with an emphasis on prevention and cost-effective strategies.

    You’ll find authoritative, evidence-based coverage of more than 1,000 diseases and disorders including concise, yet thorough synopsis of diagnosis and treatment. Presented in full-color, this single source reference has been fully updated with the latest developments and breakthroughs in medicine, guidelines, references, drug prices, and more. This essential clinical companion features:

     • A strong emphasis on the practical aspects of clinical diagnosis and patient management

    • Detailed review of all internal medicine disciplines, including geriatrics, preventive medicine, and palliative care, plus gynecology and obstetrics, dermatology, ophthalmology, neurology, psychiatry, and more

    • An annual update on HIV/AIDS and other new, emerging viral infections

     • Specific information regarding disease prevention and prognosis

    • Medication treatment tables, with indexed trade names and updated prices

    • Key recent references on each topic with PMID numbers for quick online access

     • Many full-color photographs, tables, figures and other illustrations Here are some of the many updates and additions:

     • Extensive updating of tables and images

    • New FDA-approved medication for multiple sclerosis

     • New summary of recommended FDA treatment regimens for hepatitis C

     • U.S. Preventive Services Task Force recommendations for osteoporosis, prostate cancer, ovarian cancer, and cervical cancer

    • Extensive update of immune modulation therapy and adjuvant treatments of breast cancer

     • Targeted therapies for advanced non-small cell lung cancers

    • Thoroughly revised chapter on viral and rickettsial infections, including recent measles, polio, and acute flaccid paralysis outbreaks, and on related immunizations

    • Clarification of the appropriate role of opioids and buprenorphine formulations in chronic pain management

    • Revised section on health care for sexual and gender minority patients

     • Information on new biologic agents for asthma, and many other disorders


    Title Page

    Copyright Page




    1. Disease Prevention & Health Promotion

    2. Common Symptoms

    3. Preoperative Evaluation & Perioperative Management

    4. Geriatric Disorders

    5. Palliative Care & Pain Management

    6. Dermatologic Disorders

    7. Disorders of the Eyes & Lids

    8. Ear, Nose, & Throat Disorders

    9. Pulmonary Disorders

    10. Heart Disease

    11. Systemic Hypertension

    12. Blood Vessel & Lymphatic Disorders

    13. Blood Disorders

    14. Disorders of Hemostasis, Thrombosis, & Antithrombotic Therapy

    15. Gastrointestinal Disorders

    16. Liver, Biliary Tract, & Pancreas Disorders

    17. Breast Disorders

    18. Gynecologic Disorders

    19. Obstetrics & Obstetric Disorders

    20. Rheumatologic, Immunologic, & Allergic Disorders

    21. Electrolyte & Acid-Base Disorders

    22. Kidney Disease

    23. Urologic Disorders

    24. Nervous System Disorders

    25. Psychiatric Disorders

    26. Endocrine Disorders

    27. Diabetes Mellitus & Hypoglycemia

    28. Lipid Disorders

    29. Nutritional Disorders

    30. Common Problems in Infectious Diseases & Antimicrobial Therapy

    31. HIV Infection & AIDS

    32. Viral & Rickettsial Infections

    33. Bacterial & Chlamydial Infections

    34. Spirochetal Infections

    35. Protozoal & Helminthic Infections

    36. Mycotic Infections

    37. Disorders Related to Environmental Emergencies

    38. Poisoning

    39. Cancer

    40. Genetic & Genomic Disorders

    41. Sports Medicine & Outpatient Orthopedics

    42. Lesbian, Gay, Bisexual, & Transgender Health


  • 29500lei 270.00 lei

    Now reflecting a greater focus on today's multidisciplinary approach to care, Critical Care Handbook of the Massachusetts General Hospital, 6th Edition, remains your go-to guide for practical, complete, and current information on medical and surgical critical care. The user-friendly, outline format is designed for rapid reference, providing reliable, hospital-tested protocols that reflect today's most advanced critical care practices. Key Features*Heavily revised to reflect today's need to include all care providers to optimize treatment*New section on Health Care Services, with chapters on handovers and transitions, long-term outcomes of ICU patients, EICU and electronic systems, quality improvement, and more*New chapters on critical care management of Ebola virus disease, ECMO and ventricular assist devices, and critical care of the obstetrical patient*New videos available online*Complete, concise, full-color coverage of this rapidly enlarging field*Convenient pocket size for on-the-go referenceNow with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like:*Complete content with enhanced navigation*Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web*Cross-linked pages, references, and more for easy navigation*Highlighting tool for easier reference of key content throughout the text* Ability to take and share notes with friends and colleagues*Quick reference tabbing to save your favorite content for future use

  • 35000lei 275.00 lei



    Edited by Adam Feather, MBBS, FRCP, FAcadMEd; David Randall, MA, MRCP; and Mona Waterhouse, MA, MRCP

    Contributors comprise consultants at the top of their fields, paired with younger doctors closer to the exam experience, to ensure authority and relevance.

    Enhanced e-book accompanies the print book, for ease of transportation and use on the move.

    International Advisory Board, led by Professor Janaka de Silva and Professor Senaka Rajapakse, providing guidance for global coverage from across the world.

    Contributions to the e-book by members of the International Advisory Board to amplify areas of clinical importance in their parts of the world.



    Table of Contents:


    1. Diagnosis: The art of being a doctor

    Core Skills and Knowledge

    Diagnosis in the Clinical Consultation

    The medical consultation

    Clinical diagnostic reasoning

    Communicating a diagnosis

    Diagnosis, artificial intelligence and the future of medicine

    2. Human genetics

    Core Skills and Knowledge

    Clinical skills for genetic medicine


    Clinical genetics

    The cellular basis of genetics

    Genetic disorders

    Techniques for studying the genetic code

    Genomic medicine

    The genetic basis of cancer

    3. Immunity

    Core Skills and Knowledge

    Introducing the tissues, cells and molecules of the immune system

    Innate immune system

    Adaptive immune system

    Cell migration

    HLA molecules and antigen presentation

    The immune system in concert

    Laboratory investigations of the immune system

    Clinical immunodeficiency

    Allergic disease (immediate hypersensitivity)

    Autoimmune disease

    Organ rejection in clinical transplantation

    Immune-based therapies

    4. Evidence-based practice

    Core Skills and Knowledge


    Asking Answerable Questions

    Searching for the Evidence

    Appraising the Evidence

    Applying the Evidence

    Section 1: Asking Answerable Questions and Searching for the Evidence

    Section 2: Critical Appraisal

    Section 3: Interpreting Odds Ratios, Confidence Intervals and P-Values

    Section 4: Multiple Choice Questions

    5. Ethical practice and clinical communication

    Core Skills and Knowledge

    Ethics and the law

    Communication in medicine

    6. Malignant disease

    Core Skills and Knowledge

    Clinical skills for malignant disease


    The biology of cancer

    Aetiology and epidemiology

    Screening and investigations

    Principles of cancer treatment

    Acute oncology

    Common solid tumour treatment

    Lung cancer

    Breast cancer

    Upper gastrointestinal cancers

    Lower gastrointestinal cancers

    Hepatobiliary and pancreatic cancers

    Urological cancers

    Gynaecological cancers

    Brain tumours

    Head and neck cancer

    Metastatic cancer of unknown primary

    7. Palliative care and symptom control

    Core Skills and Knowledge

    Introduction and General Aspects

    Symptom Control

    Palliative Care in Non-Malignant Disease

    Care of the Dying

    8. Sepsis and the treatment of bacterial infection

    Core Skills and Knowledge

    clinical skills for infection and sepsis



    recognition of sepsis

    Management of Sepsis

    Antimicrobial Stewardship

    Antibiotic Therapies

    9. Water balance, fluids and electrolytes

    Core skills and knowledge

    Clinical skills for water balance, fluids and electrolytes

    Water and Electrolytes

    Disorders of sodium concentration

    Disorders of potassium concentration

    Disorders of magnesium concentration

    Disorders of phosphate concentration

    Acid–Base Disorders

    10. Critical care medicine

    Core Skills and Knowledge


    Clinical approach to the critically ill patient

    Applied cardiorespiratory physiology

    Disturbances of acid–base balance

    Shock, sepsis and acute disturbances of haemodynamic function

    Respiratory failure

    Acute respiratory distress syndrome

    Acute Kidney injury

    Neurocritical care


    11. Surgery

    Core Skills and Knowledge

    Clinical skills for surgery


    The pathophysiology of surgery

    Management of the perioperative patient

    The patient journey in surgery

    Surgical Ethics, Consent and the Law

    12. Prescribing, therapeutics and toxicology

    Core Skills and Knowledge


    Why do patients need drugs?

    The choice of drug

    The dose

    Prescribing in special populations

    Monitoring drug therapy

    Adverse drug reactions

    Drug interactions

    Information sources


    Clinical approach to the poisoned patient

    Principles of management of poisoning

    Specific poisons

    Poisons in the natural world: additional online content

    13. Global health

    Core Skills and Knowledge


    Millennium and Sustainable Development Goals

    Global Burden of Disease


    Water and Sanitation

    Organizations and the global health agenda


    Maternal and Child Health

    Mental health

    Accidents and Trauma

    Conflict and Catastrophe

    Economics and Politics in Global Health

    Social Determinants of Health

    Human rights and the value of engagement in global health

    14. Public health

    Core Skills and Knowledge


    Key Concepts in Public Health

    Pillars of Public Health

    15. Geriatric medicine, frailty and multimorbidity

    Core Skills and Knowledge



    Investigations in Older Adults

    Taking a History

    Multimorbidity, Sarcopenia and Frailty

    Comprehensive Geriatric Assessment

    Advance Care Planning

    The Most Common Issues in Older People

    Ageing Well and Advantages of Ageing

    16. Haematology

    Core Skills and Knowledge

    Clinical skills for haematology




    The red cell

    Anaemia: an introduction

    Microcytic anaemia

    Normocytic anaemia

    Macrocytic anaemias

    Anaemia due to marrow failure (aplastic anaemia)

    Haemolytic anaemias: an introduction

    Inherited haemolytic anaemia

    Acquired haemolytic anaemia


    The spleen

    Blood transfusion

    Blood groups

    Procedure for blood transfusion in hospitals

    Complications of blood transfusion

    Strategies for the avoidance of unnecessary transfusion

    Blood, blood components and blood products

    The white cell


    Vascular disorders

    Platelet disorders

    Inherited coagulation disorders

    Acquired coagulation disorders

    17. Haematological oncology

    Core Skills and Knowledge

    Clinical skills for haematological oncology




    Clinical features



    MDS/MPN overlap syndromes


    Myeloma and other plasma cell disorders

    18. Rheumatology

    Core Skills and Knowledge

    Clinical skills for rheumatology

    Approach to the patient

    Anatomy and physiology of the normal joint

    Investigation of rheumatic disease

    Clinical conditions in rheumatology

    Common regional musculoskeletal problems

    Chronic pain syndromes

    Analgesic and anti-inflammatory drugs for musculoskeletal problems

    Disorders of collagen


    Inflammatory Arthritis

    Rheumatoid arthritis


    Infections of joints

    Autoimmune rheumatic diseases

    Systemic inflammatory vasculitis

    Arthritis in children

    Rheumatological problems seen in other diseases

    Miscellaneous arthropathies

    19. Bone disease

    Core Skills and Knowledge

    Clinical skills for bone disease

    Anatomy and physiology of bone

    Investigation of bone and calcium disorders



    Paget’s disease of bone

    Rickets and osteomalacia

    Bone infections

    Neoplastic disease of bone

    Scheuermann’s disease

    20. Infectious disease

    Core Skills and Knowledge

    Core content

    Clinical skills for infectious disease


    Clinical approach to the patient with a suspected infection

    Epidemiology and prevention of infections

    Principles and mechanisms of infection

    Viral Infections

    Virus infections of the skin and mucous membranes

    Virus infections of the respiratory tract

    Systemic viral infections

    Virus infections of the nervous system

    Virus infections of the gastrointestinal tract

    Viral hepatitis

    Viruses and malignant disease

    Viral haemorrhagic fevers

    Antiviral drugs

    Transmissible Spongiform Encephalopathies (Prion Diseases)

    Bacterial Infections

    Bacterial infections of the skin and soft tissues

    Bacterial infections of the respiratory tract

    Bacterial infections of the gastrointestinal tract

    Bacterial infections of the cardiovascular system

    Bacterial infections of the nervous system

    Bacterial bone and joint infections

    Bacterial infections of the urinary tract

    Systemic/multisystem bacterial infections

    Bacterial infections seen in developing and tropical countries

    Antibiotic therapies

    Fungal Infections

    Systemic fungal infections

    Subcutaneous fungal infections

    Superficial fungal infections

    Antifungal drugs

    Protozoal Infections

    Blood and tissue protozoa

    Gastrointestinal protozoa

    Helminthic Infections




    Arthropod Ectoparasites

    21. Endocrinology

    Core Skills and Knowledge

    Clinical skills for endocrinology


    The pituitary gland and hypothalamus

    Hypothalamo–Pituitary–adrenal axis

    The thyroid axis

    Hypothalamo–pituitary–gonadal axis

    Growth and puberty

    The Thirst Axis

    Disorders of Calcium Metabolism

    Hypoglycaemia in the non-diabetic patient

    Other endocrine disorders

    22. Dermatology

    Core Skills and Knowledge

    Clinical Skills for Dermatology


    Skin structure and function

    Investigation of Skin Disease

    Principles of Dermatological Therapy

    Erythroderma and Loss of Skin Function (‘Skin Failure’)

    Common rashes

    Skin Infections

    Human Immunodeficiency Virus and the Skin

    Skin Signs of Systemic Disease


    Blistering and Bullous Skin Disease

    Skin Tumours

    Disorders of Pigmentation

    Nail Disorders

    Hair Disorders

    Birth Marks and Neonatal Rashes

    Drug Eruptions

    23. Diabetes mellitus

    Core Skills and Knowledge

    Clinical skills for diabetes mellitus


    Physiology of insulin structure, secretion and action

    Classification of diabetes

    Clinical Approach to the Patient With Diabetes

    Prevention of Type 2 Diabetes

    Management of diabetes

    Diabetic metabolic emergencies

    Complications of diabetes

    Psychosocial Implications of Diabetes

    Diabetes in special situations

    Organization of diabetes care

    24. Lipid and metabolic disorders

    Core Skills and Knowledge





    Disorders of lipid metabolism

    Inherited metabolic diseases

    25. Liaison psychiatry

    Core Skills and Knowledge


    Clinical approach to the patient with a psychiatric disorder

    Classification of psychiatric disorders

    Aetiology of psychiatric disorders

    Psychiatric aspects of physical diseases

    Sick role and illness behaviour

    Functional somatic syndromes

    Somatoform disorders

    Dissociative/conversion disorders

    Sleep difficulties

    Mood (affective) disorders

    Suicide and self-harm

    Anxiety disorders

    Alcohol misuse and dependence

    Drug misuse and dependence


    Organic mental disorders

    Eating disorders

    Sexual disorders

    Personality disorders

    Involuntary Detention

    Mental Capacity Act

    26. Neurology

    Core Skills and Knowledge

    Clinical skills for neurology


    Clinical approach to the patient with neurological disease

    Functional neuroanatomy

    Cranial nerves

    Motor control systems

    Lower motor neurone lesions

    Sensory pathways and pain

    Bladder control and sexual dysfunction

    Investigation of neurological disease

    Unconsciousness and coma


    Intracranial haemorrhage

    Headache, migraine and facial pain

    Epilepsy and loss of consciousness

    Movement disorders

    Neuroinflammatory disorders

    Nervous system infection


    Traumatic brain injury

    Spinal cord disease

    Neurodegenerative diseases

    Congenital disorders

    Neurogenetic disorders

    Paraneoplastic syndromes

    Peripheral nerve disease

    Muscle diseases

    27. Ear, nose and throat and eye disease

    Core Skills and Knowledge

    Introduction to ENT

    Clinical approach to the patient with an ENT complaint

    Disorders of the Ear

    Clinical Approach to the Patient With a Disorder of the Ear

    Common disorders of the ear

    Disorders of the Nose

    Clinical Approach to the Patient With a Disorder of the Nose

    Common disorders of the nose

    Disorders of the Throat

    Clinical Approach to the Patient With a Disorder of the Throat

    Common disorders of the throat

    Disorders of the Eye

    Applied Anatomy and Physiology

    Clinical Approach to the Patient With a Disorder of the Eye

    Common disorders of the eye

    28. Respiratory disease

    Core Skills and Knowledge

    Clinical skills for respiratory medicine

    Function of the respiratory system

    Clinical Approach to the Patient with Respiratory Disease

    Diseases of the Upper Respiratory Tract

    Obstructive Respiratory Disease


    Respiratory Infection

    Pleural Disease

    Tumours of the Respiratory Tract


    Interstitial Lung Diseases

    Lung and Heart–Lung Transplantation

    Occupational Lung Disease

    Miscellaneous Respiratory Disorders

    Disorders of the Diaphragm

    Mediastinal Lesions

    29. Venous thromboembolic disease

    Core Skills and Knowledge


    Pathogenesis of Thrombosis


    Epidemiology and Risk Factors

    Clinical Features




    Investigation of newly diagnosed venous thrombosis


    Anticoagulant agents

    30. Cardiology

    Core Skills and Knowledge

    Clinical skills for cardiology

    ECG interpretation

    Anatomy, physiology and embryology of the heart

    Clinical approach to the patient with heart disease

    Therapeutic procedures

    Cardiac arrhythmias

    Bradycardias and heart block

    Supraventricular tachycardias

    Ventricular tachyarrhythmias

    Heart failure

    Coronary artery disease


    Acute coronary syndromes

    Valvular heart disease

    Aortic valve

    tricuspid valve

    Pulmonary valve

    Prosthetic valves

    Infective endocarditis

    Congenital heart disease

    Marfan’s syndrome

    Pulmonary heart disease

    Myocardial and endocardial disease

    Myocardial disease

    Pericardial disease

    Peripheral vascular disease

    Peripheral venous disease

    31. Hypertension

    Core Skills and Knowledge


    Clinical Approach to the Patient with Hypertension

    Measurement of blood pressure

    Phenotypes of Hypertension

    Causes of raised blood pressure

    Thresholds and Targets In Hypertension

    Hypertensive Target Organ Damage


    Managing blood pressure in hospital

    32. Gastroenterology

    Core Skills and Knowledge

    Clinical Skills for Gastroenterology


    Anatomy and physiology of the gastrointestinal tract

    Investigation of Gastrointestinal Disease

    Functional Gastrointestinal Disorders


    Salivary Glands

    Pharynx and Oesophagus

    Stomach and Duodenum

    Acute and Chronic Gastrointestinal Bleeding

    Small Intestine

    Inflammatory Bowel Disease

    Colon and Rectum

    The Acute Abdomen


    33. Nutrition

    Core Skills and Knowledge


    Water and Electrolyte Balance

    Dietary Requirements

    Protein–Energy Malnutrition


    Fat-soluble vitamins

    Water-soluble vitamins

    Dietary Antioxidants

    Homocysteine, cardiovascular disease and B vitamins


    Nutrition and Ageing


    Nutritional Support

    Food Allergy and Food Intolerance


    34. Liver disease

    Core Skills and Knowledge

    Clinical skills for liver disease


    Anatomy of the liver and biliary system

    Functions of the liver

    Investigations in the patient with liver disease



    Acute hepatic failure

    Autoimmune hepatitis

    Drug-induced chronic hepatitis

    Chronic hepatitis of unknown cause

    Non-alcoholic fatty liver disease


    Alcoholic liver disease

    Budd–chiari syndrome

    Hepatic sinusoidal obstruction syndrome

    Fibropolycystic diseases

    Liver abscess

    Other infections of the liver

    Liver disease in pregnancy

    Liver tumours

    Miscellaneous conditions of the liver

    Drugs and the liver

    35. Biliary tract and pancreatic disease

    Core Skills and Knowledge


    Gall Bladder and Biliary System

    Biliary system

    Miscellaneous conditions of the biliary tract



    Pancreatic cancer

    Pancreatic neuroendocrine tumours

    Clinical syndromes



    36. Kidney and urinary tract disease

    Core Skills and Knowledge

    Clinical Skills for Nephrology



    Anatomy and Physiology of the Kidney and Urinary Tract

    Investigation of Renal and Urinary Tract Disease

    The Glomerulus and Glomerular Disease

    Kidney Involvement in Other Diseases

    Hypertension and the Kidney

    Other Vascular Disorders of the Kidney

    Renal Calculi and Nephrocalcinosis

    Urinary Tract Obstruction

    Drugs and the Kidney

    Urinary Tract Infection

    Tubulointerstitial Nephritis

    Acute Kidney Injury

    Chronic Kidney Disease

    Cystic Renal Disease

    Tumours of the Kidney and Genitourinary Tract

    Diseases of the Prostate Gland

    The Urinary Tract in the Elderly

    37. Sexually transmitted infections and human immunodeficiency virus

    Core Skills and Knowledge

    Clinical skills for STI and HIV care

    Sexually transmitted infections

    Asymptomatic STI screening

    Investigation of STIs

    Management, prevention and control

    Specific infections

    Human immunodeficiency virus and acquired immunodeficiency syndrome

    Clinical features of untreated hiv infection

    Clinical approach to the patient with HIV

    Management of HIV-positive patients

    Specific conditions associated with HIV infection

    Prevention and control of HIV infection

    38. Obstetric medicine

    Core Skills and Knowledge

    Clinical Skills for Obstetric Medicine


    Hypertensive Disorders

    Liver Disease

    Cardiac Disease

    Thromboembolic Disease

    Respiratory Disease

    Neurological Disease

    Endocrine Disease

    Renal Disease

    Skin Disorders


    Prescribing in Pregnancy

    39. Women’s health

    Core Skills and Knowledge

    Clinical skills for women’s health


    The life course approach


    Heavy Menstrual Bleeding

    Abortion/Termination of Pregnancy

    Urinary Incontinence

    Domestic abuse and violence

    Gynaecological cancers

    40. Men’s health

    Core Skills and Knowledge

    Clinical Skills For Men’s Health


    Specific Diseases of Men

    Diseases of the prostate gland

    Diseases of the Penis

    Testicular and Spermatic Cord Disease

    Lack of Libido and Erectile Dysfunction


    The Ageing Male

    41. Environmental medicine

    Core Skills and Knowledge

    Air pollution

    Heat Injury

    Cold injury

    High altitude



    Ionizing radiation

    Electric shock

    Lightning strike

    Inhaled smoke


    Normal Values


  • Signs & Symptoms in Clinical Practice
    La comanda in aproximativ 4 saptamani
    280.00 lei

    This book on and signs and symptoms, which is indexed in alphabetical order from which the physician will be able to weave a clinical narrative, anatomically and pathophysiologically explicit, to form the accurate diagnostic hypotheses. It is compact, handy and bedside clinical companion book for all dedicated healthcare professionals who are committed to evaluate the patient accurately on the basis of signs and the symptoms. Consists of 91 chapters, enriched with knowledge of about more than 100 contributors. Covers almost all the possible signs and the symptoms, commonly seen in the day-to-day clinical practice. Useful in evaluating the patients in early stages of the complaints and also helpful in initial treatment and management. This book is helpful for undergraduates, postgraduates, residents, and emergency physicians.

  • 290.00 lei

     mprove medical and developmental outcomes in high-risk infants with evidence-based management strategies

    "Beyond the NICU" is the first book to deliver practical, evidence-based strategies for healthcare providers caring for the NICU graduate during convalescence and after discharge. It is a guide to the successful transition of a high-risk infant from intensive care to the intermediate-level nursery, and then, to help the child thrive outside of the hospital in a home environment.

    To advance the standard of care of these vulnerable patients, "Beyond the NICU" draws together clinically focused guidelines to improve patient outcomes and reduce hospital readmissions. Drawing on an international team of respected authorities, "Beyond the NICU" provides the strategies necessary to ensure the success of convalescing NICU graduates in both inpatient and outpatient settings. Doody's Review! Score: 95/100 
    This is a nearly 1,000-page softcover book written by over 100 contributors on convalescent neonatal care and post-discharge care of the high-risk infant. The format is similar to other neonatal handbooks (Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 7th edition, Gomella, et al. (McGraw-Hill, 2013); Manual of Neonatal Care, 7th edition, Cloherty et al. (Lippincott Williams & Wilkins, 2011)), but it emphasizes transitional care of the sick infant. 
    The purpose is to provide "practical, evidence-based strategiesfor the NICU graduate during convalescence and after discharge." The book functions like a practical handbook for clinicians in the NICU, covering almost all aspects of neonatal care, but emphasizing convalescent care. This is an area that has not been well covered in other neonatal books, and this book meets the objectives. 
    The audience is NICU caregivers at all levels and of all disciplines. The book is written in outline format and emphasizes care rather than pathophysiology. The senior editor, his three consultants, and many of the contributors are recognizable names in the field. 
    The 51 chapters are grouped into four sections. After an introductory section which includes chapters on the role of the primary care provider for the NICU graduate, the book covers most aspects of care of preterm and term infants in the next two sections. A final section on developmental care includes chapters on early intervention and palliative care. Although the book is supposed to emphasize convalescent and post-discharge care, much of the second and third sections deals with standard early diagnosis and treatment of common neonatal issues, which adds significant length to the book. The book is at its best when it sticks to its title and emphasizes care "beyond the NICU." Helpful appendixes include discharge checklists, home equipment, and even billing coding for the NICU graduate. Illustrations and tables are sparse, but some are unique and very helpful. 
    This is a unique neonatal book in its emphasis on convalescent and post-discharge care for the sick neonate. It should become a standard text for clinicians in this field and, as it matures in subsequent editions, should abbreviate the acute care sections and concentrate on its title.

  • 34600lei 300.00 lei

    Back by popular demand: the world's most widely-used medical reference, now in its 20th edition. The Merck Manual of Diagnosis and Therapy has been thoroughly updated and expanded with a larger trim size to include 40% new and revised content, including 36 new chapters with more than 200 tables and 100 figures.

    Packed with essential information on diagnosing and treating medical disorders, this comprehensive guide was written by a team of renowned medical experts. It is intended for everyday use by healthcare professionals to ensure delivery of the best care to their patients. The new Merck Manual of Diagnosis and Therapy makes it easy to find the right information at the moment it's needed, with the help of section thumb tabs. It is a must-have for medical students, residents, practicing physicians, nurses, and allied health professionals.

    • New larger trim 7 3/4 x 9 1/4 to accommodate 40% new content
    • 36 completely new chapters
    • Revised and expanded chapters in Cardiovascular, Genitourinary, Gynecologic, Neurologic, Pregnancy, and Infants and Children
    • Pediatrics and trauma section significantly revised and expanded
    • Key Points summarize the facts at-a-glance
    • New Pearls & Pitfalls highlight noteworthy medical info and areas of caution
    • 16-page full-color insert aids visual recognition of skin, eye, and oral disorders

    Table Of Contents:

    Guide for Readers


    Editors and Editorial Board



    1 Nutritional Disorders

    2 Gastrointestinal Disorders

    3 Hepatic and Biliary Disorders

    4 Musculoskeletal and Connective Tissue Disorders

    5 Pulmonary Disorders

    6 Critical Care Medicine

    7 Cardiovascular Disorders

    8 Ear, Nose, and Throat, and Disorders

    9 Dental Disorders

    10 Eye Disorders

    11 Dermatologic Disorders

    12 Hematology and Oncology

    13 Endocrine and Metabolic Disorders

    14 Immunology; Allergic Disorders

    15 Infectious Diseases

    16 Psychiatric Disorders

    17 Neurologic Disorders

    18 Genitourinary Disorders

    19 Gynecology and Obstetrics

    20 Pediatrics

    21 Geriatrics

    22 Clinical Pharmacology

    23 Injuries; Poisoning

    24 Special Subjects


    Ready Reference Guides

    Normal Laboratory Values

    Trade Names of Some Commonly Used Drugs


  • ENT Essentials
    La comanda in aproximativ 4 saptamani
    310.00 lei

    This book is a comprehensive guide to the complete field of otolaryngology for trainees. Divided into seven sections, the manual covers all sub-specialties in ENT practice - ear, face, sleep medicine, laryngology, head and neck, rhinology and allergy, and paediatric ENT. Each section is further divided to discuss the management of various disorders within the subspecialty in question. Highly illustrated with figures and tables to enhance learning, this useful text is edited by respected ENT specialists from University of Pennsylvania School of Medicine and Temple University School of Medicine, Philadelphia. Lead editor, David Kennedy, is past President of the International Rhinology Society. Key Points Comprehensive guide to otolaryngology for trainees Highly illustrated with figures and tables Edited by recognised ENT specialists from Philadelphia Lead editor, David Kennedy, is past President of the International Rhinology Society

  • 35300lei 330.00 lei

    The new edition of this book has been fully revised with the latest advances in anaesthesia practice. Each chapter presents a step by step decision making algorithm with explanatory text and supplemental tables, providing clinicians and trainees with answers for nearly 250 anaesthetic management problems. General principles in anaesthesia care are discussed, as well as detailed examination of preoperative problems, anaesthesia in surgical specialty areas, postoperative management, and perioperative management. The fifth edition includes many new topics including robotic-assisted procedures, heart failure, epilepsy surgery, traumatic brain injury and much more. Authored by respected experts from University of Texas Health Science Centre, the book is enhanced by clinical photographs and diagrams to assist learning. Previous edition published in 2007. Key Points Fully revised, new edition detailing latest advances in anaesthesia practice Chapters presented with step by step decision making algorithm with explanatory text and tables Fifth edition includes many new topics Internationally recognised author team from University of Texas Health Science Centre

  • Clinical Atlas of Diabetes Mellitus
    La comanda in aproximativ 4 saptamani
    42000lei 400.00 lei

  • Conn's Current Therapy 2020
    La comanda in aproximativ 4 saptamani
    44600lei 400.00 lei

    Designed to suit a wide range of healthcare providers, including primary care, subspecialties, and allied health, Conn's Current Therapy has been a trusted clinical resource for more than 70 years.

    The 2020 edition continues this tradition of excellence with current, evidence-based treatment information presented in a concise yet in-depth format. More than 300 topics have been carefully reviewed and updated to bring you state-of-the-art information even in the most rapidly changing areas of medicine.

    ·        Offers personal approaches from recognized leaders in the field, covering common complaints, acute diseases, and chronic illnesses along with the most current evidence-based clinical management options.

    ·        Follows a consistent, easy-to-use format throughout, with diagnosis, therapy, drug protocols, and treatment pearls presented in quick-reference boxes and tables for point-of-care answers to common clinical questions.

    ·        Includes new and significantly revised chapters on neurofibromatosis, autism, psoriatic arthritis, and postpartum depression.

    ·        Features thorough updates in areas critical to primary care, including Acute Myocardial Infarction . Hypertension . Peripheral Arterial Disease . Valvular Heart Disease . Hepatitis C . Irritable Bowel Syndrome . Obsessive Compulsive Disorder . Chronic Obstructive Pulmonary Disease . Fibromyalgia . Menopause . Travel Medicine . and more.

    ·        Provides current drug information thoroughly reviewed by PharmDs.

    ·        Shares the knowledge and expertise of new contributors who provide a fresh perspective in their specialties.

    ·        Features nearly 300 images, including algorithms, anatomical illustrations, and photographs, that provide useful information for diagnosis.

    ·        Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

  • 44600lei 400.00 lei


    Evaluate and treat common fractures and know when to refer uncommon ones to a specialist. This quick, practical resource presents detailed illustrations, video, and current best evidence for imaging and treating fractures so you can make accurate identifications and manage patients with confidence.

    • Quickly find the information you need through a systematic, logical approach to each fracture.
    • Accurately identify fractures through an extensive selection of imaging examples.
    • Apply splints and reduce dislocations successfully thanks to detailed descriptions, illustrations, and narrated video.
    • Tap into the latest best practices through evidence-based coverage and updated references.
    • Effectively manage emergency situations using guidelines for emergent referral, greater detail regarding methods for closed reductions for fractures and dislocations, and more.
    • Benefit from expanded content specifically for the emergency medicine setting, including CT, MRI, and ultrasound imaging, procedural sedation, and discharge reassessment.


    ·         ·  1.  Fracture management in primary care and emergency medicine settings

    ·         ·  Primary care physicians

    ·         ·  Emergency medicine physicians

    ·         ·  Nurse practitioners and physician assistants

    ·         ·  References

    ·         ·  2.  General principles of fracture care

    ·         ·  Bone composition

    ·         ·  Fracture healing

    ·         ·  Potential fracture sites

    ·         ·  Fracture description

    ·         ·  Fracture selection and referral guidance

    ·         ·  Overview of acute management

    ·         ·  Overview of definitive care

    ·         ·  Late fracture complications

    ·         ·  Management of pediatric fractures

    ·         ·  References

    ·         ·  3.  Finger fractures

    ·         ·  Distal phalanx fractures

    ·         ·  Mallet finger

    ·         ·  Flexor digitorum profundus avulsion (Jersey finger)

    ·         ·  Distal interphalangeal joint dislocation

    ·         ·  Middle phalanx shaft fractures (adult)

    ·         ·  Middle phalanx fractures (pediatric)

    ·         ·  Proximal interphalangeal joint injuries

    ·         ·  Avulsion of the central slip of the extensor tendon (boutonniere injury)

    ·         ·  Lateral avulsion fractures

    ·         ·  Proximal interphalangeal joint dislocation

    ·         ·  Proximal phalanx shaft fractures (adult)

    ·         ·  Pediatric (physeal) fractures of the proximal phalanx

    ·         ·  Dislocations and ligament injuries of the metacarpophalangeal joint

    ·         ·  Dislocations and ligament injuries of the thumb metacarpophalangeal joint

    ·         ·  References

    ·         ·  4.  Metacarpal fractures

    ·         ·  Metacarpal head

    ·         ·  Metacarpal neck

    ·         ·  Metacarpal shaft

    ·         ·  Metacarpal base

    ·         ·  Dislocations of the carpometacarpal joint

    ·         ·  First metacarpal fractures (adult)

    ·         ·  First metacarpal fractures (pediatric)

    ·         ·  References

    ·         ·  5.  Carpal fractures

    ·         ·  Scaphoid fractures (adult)

    ·         ·  Scaphoid fractures (pediatric)

    ·         ·  Triquetrum fractures

    ·         ·  Lunate fractures

    ·         ·  Hamate fractures

    ·         ·  Capitate fractures

    ·         ·  Pisiform fractures

    ·         ·  Trapezium fractures

    ·         ·  Trapezoid fractures

    ·         ·  Carpal dislocations

    ·         ·  References

    ·         ·  6.  Radius and ulna fractures

    ·         ·  Distal radius fractures (adult)

    ·         ·  Distal radius fractures (pediatric)

    ·         ·  Metaphyseal fractures

    ·         ·  Physeal fractures

    ·         ·  Fractures of the shaft of the radius (adult): Galeazzi fracture

    ·         ·  Fractures of the shaft of the radius (pediatric)

    ·         ·  Both-bone forearm fractures (adult)

    ·         ·  Both-bone forearm fractures (pediatric)

    ·         ·  Fractures of the ulnar shaft

    ·         ·  Monteggia fractures (adult)

    ·         ·  Monteggia fractures (pediatric)

    ·         ·  Wrist dislocations (radiocarpal joint)

    ·         ·  References

    ·         ·  7.  Elbow fractures

    ·         ·  Radial head and neck

    ·         ·  Olecranon

    ·         ·  Coronoid process

    ·         ·  Distal humerus (adult)

    ·         ·  Supracondylar and transcondylar fractures

    ·         ·  Intercondylar fractures

    ·         ·  Condylar fractures

    ·         ·  Medial epicondyle fractures

    ·         ·  Distal humerus (pediatric)

    ·         ·  Supracondylar fractures

    ·         ·  Lateral condyle fractures

    ·         ·  Medial epicondyle fractures

    ·         ·  Little league elbow

    ·         ·  Elbow dislocation

    ·         ·  References

    ·         ·  8.  Humerus fractures

    ·         ·  Anatomic considerations

    ·         ·  Proximal humerus fractures (adult)

    ·         ·  Proximal humerus fractures (pediatric)

    ·         ·  Midshaft fractures of the humerus

    ·         ·  Shoulder (glenohumeral) dislocations

    ·         ·  References

    ·         ·  9.  Clavicle and scapula fractures

    ·         ·  Clavicle fractures

    ·         ·  Fractures of the middle third of the clavicle

    ·         ·  Fractures of the distal third of the clavicle

    ·         ·  Fractures of the proximal third of the clavicle

    ·         ·  Scapula fractures

    ·         ·  References

    ·         ·  10.  Spine fractures

    ·         ·  Cervical spine fractures (adult)

    ·         ·  Cervical spine fractures (pediatric)

    ·         ·  Thoracolumbar spine fractures (adult)

    ·         ·  Compression fractures

    ·         ·  Spinous process and transverse process fractures

    ·         ·  Burst fractures

    ·         ·  Thoracolumbar spine fractures (pediatric)

    ·         ·  Spondylolysis

    ·         ·  Nontraumatic thoracolumbar fractures

    ·         ·  Tumors

    ·         ·  Vertebral osteomyelitis

    ·         ·  References

    ·         ·  11.  Femur and pelvis fractures

    ·         ·  Femoral neck fractures

    ·         ·  Intertrochanteric fractures

    ·         ·  Trochanteric fractures

    ·         ·  Femoral shaft fractures

    ·         ·  Stress fractures of the femur

    ·         ·  Hip dislocations

    ·         ·  Pelvic fractures

    ·         ·  Acetabular fractures

    ·         ·  References

    ·         ·  12.  Patellar, tibial, and fibular fractures

    ·         ·  Patellar fractures and dislocations

    ·         ·  Patellar dislocation

    ·         ·  Tibial fractures

    ·         ·  Tibial plateau fractures

    ·         ·  Disposition

    ·         ·  Tibial shaft fractures

    ·         ·  Stress fractures of the tibia

    ·         ·  Fractures of the shafts of the tibia and fibula

    ·         ·  Fibular fractures

    ·         ·  Stress fractures of the fibula

    ·         ·  References

    ·         ·  13.  Ankle fractures

    ·         ·  Ankle fractures (adult)

    ·         ·  Ankle fractures (pediatric)

    ·         ·  Distal tibial fractures (pediatric)

    ·         ·  Distal fibular fractures (pediatric)

    ·         ·  Ankle dislocation

    ·         ·  References

    ·         ·  14.  Calcaneus and other tarsal fractures

    ·         ·  Calcaneus fractures (adult)

    ·         ·  Extraarticular fracture: Anterior process

    ·         ·  Extraarticular fracture: Medial or lateral process

    ·         ·  Extraarticular fracture: Tuberosity

    ·         ·  Extraarticular fracture: Sustentaculum tali

    ·         ·  Extraarticular fracture: Body not involving the subtalar joint

    ·         ·  Intraarticular fractures

    ·         ·  Calcaneus stress fractures

    ·         ·  Calcaneus fractures (pediatric)

    ·         ·  Talus fractures (adult)

    ·         ·  Osteochondral dome fractures

    ·         ·  Fracture of the lateral process of the talus (snowboarder’s fracture)

    ·         ·  Talus fractures (pediatric)

    ·         ·  Navicular fractures (adult)

    ·         ·  Navicular stress fracture

    ·         ·  Navicular fractures (pediatric)

    ·         ·  Cuboid and cuneiform fractures

    ·         ·  References

    ·         ·  15.  Metatarsal fractures

    ·         ·  Fractures of the metatarsal shafts

    ·         ·  Stress fractures of the metatarsal shafts

    ·         ·  Proximal fractures of the first through fourth metatarsals

    ·         ·  Fractures of the proximal fifth metatarsal

    ·         ·  Avulsion fractures of the styloid

    ·         ·  Fractures of the metaphyseal–diaphyseal junction

    ·         ·  Stress fracture of the fifth metatarsal diaphysis

    ·         ·  References

    ·         ·  16.  Toe fractures

    ·         ·  Toe fractures

    ·         ·  Toe dislocations

    ·         ·  Sesamoid fractures

    ·         ·  References

    ·         ·  17.  Facial and skull fractures

    ·         ·  Nasal fractures

    ·         ·  Fractures of other facial bones

    ·         ·  Skull fractures

    ·         ·  References

    ·         ·  18.  Rib fractures

    ·         ·  Anatomic considerations

    ·         ·  Mechanism of injury

    ·         ·  Rib fractures after trauma

    ·         ·  Stress fractures of the ribs

    ·         ·  References

  • 420.00 lei



    Ideal for residency, fellowship, clinical practice, and board review, the National Kidney Foundation’s Primer on Kidney Diseases, 7th Edition, by Drs. Scott J. Gilbert and Daniel E. Weiner, offers comprehensive coverage of adult and pediatric kidney diseases in an authoritative, practical resource. Well organized and highly readable, it covers every relevant topic in the field, from anatomy, physiology, and pathophysiology, to diagnosis and management of kidney disease, to fluid and electrolyte disorders, hypertension, dialysis, and renal transplantation.


    Trusted by nephrologists at all levels of experience for nearly 25 years, this powerful learning tool and clinical reference is a joint publication of Elsevier and the National Kidney Foundation.

    New To This Edition:

    Thoroughly covers hot topics in this fast-changing field, including ongoing clinical research and changing treatment protocols.

    A new chapter on inherited kidney diseases, with a specific focus on APOL1 and the implications of APOL1 carrier status for kidney disease in African-Americans.

    A new approach to membranoproliferative glomerulonephritis, focusing on the role of complement as a way to approach both the diagnosis and treatment of these diseases.

    Additions to the chapter on hemodialysis, specifically incorporating information on hemodiafiltration.

    Updates in the management of hypertension, incorporating results from SPRINT and ACCORD as well as data on treatment of renal artery sclerosis and renal denervation into the approach for blood pressure management.

    Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

    Table Of Contents:

    Structure and Function of the Kidney

    1. Overview of Kidney Structure and Function

    2. Kidney development

    3. Assessment of Kidney Function in Acute and Chronic Settings

    4. Urinalysis and Urine Microscopy

    5. Hematuria and Proteinuria

    6. Imaging the Kidneys

    Acid/Base and Electrolytes

    7. Hyponatremia and Hypoosmolar Disorders

    8. Hypernatremia

    9. Volume, Edema and the Clinical Use of Diuretics

    10. Disorders of Potassium Metabolism

    11. Disorders of Calcium, Phosphorus, & Magnesium Homeostasis

    12. Approach to Acid-Base Disorders

    13. Metabolic Acidosis

    14. Metabolic Alkalosis

    15. Respiratory Acidosis and Alkalosis

    Glomerular Diseases

    16. Glomerular Clinicopathologic Syndromes

    17. Minimal Change Nephrotic Syndrome

    18. Focal Segmental Glomerulosclerosis

    19. Membranous Nephropathy

    20. Immunoglobulin A Nephropathy and Related Disorders

    Kidney in Systemic Diseases


    22. Infection-related Glomerulonephritis

    23. Viral Nephropathies: Human Immunodeficiency Virus, Hepatitis C Virus, and Hepatitis B Virus

    24. Kidney Involvement in Systemic Vasculitis

    25. Systemic Lupus Erythematosus and the Kidney

    26. Pathogenesis, Pathophysiology, and Treatment of Diabetic Nephropathy

    27. The Kidney in Malignancy

    28. Myeloma, Amyloid and other Dysproteinemias

    29. Acute Cardiorenal Syndrome

    30. Hepatorenal Syndrome and Other Liver-Related Kidney Diseases

    Acute Kidney Injury

    31. Clinical Approach to the Diagnosis of Acute Kidney Injury

    32. Acute Tubular Injury and Acute Tubular Necrosis

    33. Acute Interstitial Nephritis

    34. Management of Acute Kidney Injury

    Drugs and the Kidney

    35. Kidney Disease Caused by Therapeutic Agents

    36. Principles of Drug Therapy in Patients with Reduced Kidney Function

    Hereditary Kidney Disease

    37. Genetics and Kidney Disease (APOL1)

    38. Genetically Based Renal Transport Disorders

    39. Sickle Cell Nephropathy

    40. Polycystic and Other Cystic Kidney Diseases

    41. Nephronophthisis and Medullary Cystic Kidney Disease

    42. Alport’s Syndrome and Thin Basement Membrane Dz

    43. Fabry Disease

    Tubulointerstitial Diseases

    44. Chronic Tubulointerstitial Disease

    45. Obstructive Uropathy

    46. Nephrolithiasis

    47. Urinary Tract Infection and Pyelonephritis

    Special Circumstances

    48. Kidney Diseases in Infants and Children

    49. The Kidney in Pregnancy

    50. Kidney Disease in the Elderly

    51. Global Kidney Disease

    Chronic Kidney Disease

    52. Development and Progression of Chronic Kidney Disease

    53. Staging and Management of Chronic Kidney Disease

    54. Nutrition and Kidney Disease

    55. Bone Disorders in Chronic Kidney Disease

    56. Cardiac Function and Cardiovascular Disease in Chronic Kidney Disease

    57. Anemia and Other Hematologic Complications of Chronic Kidney Disease

    Dialysis and Transplantation

    58. Hemodialysis and Hemofiltration

    59. Peritoneal Dialysis

    60. Outcome of End-Stage Renal Disease Therapies

    61. Selection of Prospective Kidney Transplant Recipients and Donors

    62. Post-transplantation Monitoring and Outcomes

    63. Immunosuppression

    64. Transplant Infectious Disease


    65. Pathogenesis of Hypertension

    66. Evaluation and Management of Hypertension

    67. Secondary Hypertension



  • 56000lei 500.00 lei

    The first edition of this book, published in 2009, was the only book of its kind dedicated exclusively to the diagnosis and management of pulmonary arterial hypertension (PAH) in patients with interstitial lung disease (ILD). Over the past few years, new diagnostic tests and treatments of pulmonary arterial hypertension have been developed and tested. Diagnostic testing has led to more frequent and specific diagnosis in PAH patients, leading to the more widespread use of effective treatment and improved quality of life and reduction of mortality for PAH patients. Pulmonary Hypertension and Interstitial Lung Disease: A Clinical Guide, Second Edition provides an updated and expanded state-of-the-art overview of the problems seen by physicians in the clinical management of ILDs. The first section of the book discusses general features and includes an overview of clinical features, diagnosis and pathology of ILD. The second part discusses specific disorders such as idiopathic pulmonary fibrosis, sarcoidosis, and hypersensitivity pneumonia. Pulmonary Hypertension and Interstitial Lung Disease, Second Edition is an invaluable resource for all physicians whose practice involves the care and treatment of patients with interstitial lung disease. The first edition of this book, published in 2009, was the only book of its kind dedicated exclusively to the diagnosis and management of pulmonary arterial hypertension (PAH) in patients with interstitial lung disease (ILD). Over the past few years, new diagnostic tests and treatments of pulmonary arterial hypertension have been developed and tested. Diagnostic testing has led to more frequent and specific diagnosis in PAH patients, leading to the more widespread use of effective treatment and improved quality of life and reduction of mortality for PAH patients. Pulmonary Hypertension and Interstitial Lung Disease: A Clinical Guide, Second Edition provides an updated and expanded state-of-the-art overview of the problems seen by physicians in the clinical management of ILDs. The first section of the book discusses general features and includes an overview of clinical features, diagnosis and pathology of ILD. The second part discusses specific disorders such as idiopathic pulmonary fibrosis, sarcoidosis, and hypersensitivity pneumonia. Pulmonary Hypertension and Interstitial Lung Disease, Second Edition is an invaluable resource for all physicians whose practice involves the care and treatment of patients with interstitial lung disease.

  • 57700lei 510.00 lei



    A practical resource covering both elective and emergency procedures for the practicing vascular and endovascular clinician

    This book provides medical professionals (vascular surgeons, interventional cardiologists, interventional radiologists, endovascular neurologists, vascular medicine specialists) with a reference guide to the most common and accepted approach to endovascular management of peripheral vascular disease. It also addresses urgent interventions in the acute setting of the various vascular beds, and covers emerging areas such as stroke intervention and endovascular treatment of pulmonary embolism and vascular trauma.

    Edited by a multidisciplinary team, Endovascular Interventions offers in-depth coverage of the field in seven parts: Overview; Supra-Aortic Intervention in High Risk Patients: Innominate, Subclavian, Carotid, Vertebral and Intracranial Interventions; Interventions of the Aorta; Renal and Mesenteric Interventions; Lower Extremity Interventions; Venous Disease; and Vascular Trauma. Each section covers the technical aspects of the procedures as well as the fundamental clinical aspects which are necessary in the evaluation of patients considered for interventions. Chapters feature illustrations, case studies, key learning points, equipment lists, and sample questions and answers which can be used for Board exam practice.

    ·         Practical review of vascular and endovascular medicine covering both elective and emergency procedures

    ·         Illustrated, templated chapters provide rapid answers to questions and include case studies, key learning points, and equipment lists

    ·         Includes sample questions and answers that are handy for Board exam practice

    ·         Edited by multidisciplinary experts

    Endovascular Interventions is an excellent review book for all practicing and aspiring vascular and endovascular specialists.



    List of Contributors vii

    1 Vascular Biology 1
    Cristina Sanina, Olga L. Bockeria, Karlo A. Wiley and Jonathan E. Feig

    2 Non-Invasive Testing in Peripheral Arterial Disease 17
    Ian Del Conde and James F. Benenati

    3 Carotid and Innominate Artery Stenting for High-Risk Patients 25
    Reid Ravin, Shivani Kumar and Peter Faries

    4 Subclavian Artery Stenosis: When and How to Intervene 37
    Parham Parto and Tyrone J. Collins

    5 Vertebral Artery Occlusive Disease 45
    Mark H.Wholey and Jason M. Andrus

    6 Stroke Interventions 53
    Italo Linfante

    7 Endovascular Management of Thoracoabdominal Aneurysms 61
    William E. Beckerman and James F. McKinsey

    8 Abdominal Aortic Aneurysms: Catheter-Based Interventions 77
    Sean P. Wengerter, Kurt R. Wengerter and Michael L. Marin

    9 Aortic Dissection: Urgent Endovascular Treatment 99
    Ratna C. Singh and Evan C. Lipsitz

    10 Management of Acute Aortic Syndrome 111
    Rajesh Malik, Michael Siah and Edward Y.Woo

    11 Severe Renal Artery Stenosis:When and How to Intervene 121
    Jose D. Tafur and Christopher J.White

    12 Mesenteric Ischemia: Chronic and Acute Management 135
    Vincent Gallo, Kevin “Chaim” Herman and John H. Rundback

    13 Catheter-Based Management of Peripheral AVMs 143
    Allan M. Conway, Alfio Carroccio and Robert J. Rosen

    14 Aortoiliac Interventions 15
    Subhash Banerjee, Houman Khalili and Mehdi Shishehbor

    15 Femoropopliteal Interventions in the Claudicant Patient 167
    Pedro A. Villablanca, Cristina Sanina, Pedro R. Cox-Alomar, Prakash Krishnan and Jose M.Wiley

    16 Tibial and Pedal Plantar Interventions in Patients with Critical Limb Ischemia 183
    Anand Prasad and Haley Hughston

    17 The Diagnosis, Evaluation and Contemporary Management of Acute Limb Ischemia 207
    Michael N. Young and Douglas E. Drachman

    18 Pedal Reconstruction in Critical Limb Ischemia 221
    Amjad AlMahameed and Craig Walker

    19 Access Site Complications 227
    Miguel Alvarez Villela, Fernando D. Pastor and Robert T. Pyo

    20 Acute Deep Vein Thrombosis 243
    Ian Del Conde and James F. Benenati

    21 Chronic Venous Disorders 251
    Brett J. Carroll, Duane S. Pinto and Cristina Sanina

    22 Endovascular Treatment of Pulmonary Embolism 267
    Ian Del Conde and Barry T. Katzen

    23 Inferior Vena Cava Filters 275
    Merrill H. Stewart and James S. Jenkins

    24 Endovascular Treatment for Vascular Trauma 291
    Hallie E. Baer-Bositis, Georges M. Haidar, Taylor D. Hicks and Mark G. Davies

    Index 307



  • Rheumatoid Arthritis and Proteus
    La comanda in aproximativ 4 saptamani
    62000lei 560.00 lei

    Rheumatoid Arthritis and Proteus explores the idea that Rheumatoid arthritis is caused by a urinary tract infection as a result of Proteus bacteria. Rheumatoid arthritis is a severe, painful and crippling disease affecting millions of people throughout the world, especially women. Genetic studies over the last 30 years have shown that individuals who possess the white cell blood groups HLA-DR1/4 carry a susceptibility sequence and are more likely to develop the disease. This book uses the methods of Sir Karl Popper, the philosopher of science, to present 12 “Popper sequences” which have been identified to indicate that Proteus is the causative agent of Rheumatoid Arthritis. Rheumatoid Arthritis and Proteus proposes that Anti-Proteus therapies should be followed as early as possible to prevent the crippling and irreversible joint deformities that occur in Rheumatoid Arthritis.

  • 60600lei 560.00 lei

    Obesity is considered a complex and multifactorial disease. Its treatment, therefore, must also be multimodal and tailored to meet the needs of each patient.

    Obesity: Evaluation and Treatment Essentials presents a wide spectrum of practical treatment protocols for obesity including exercise, pharmacology, behavior modification, and dietary factors, from the point of view of the practicing physician. The book includes information about the new pharmacotherapy available for the treatment of obesity. It also includes a chapter on medical treatment of pediatric obesity that identifies the special needs of children and outlines approaches for managing the obese child. A chapter on binge eating disorder has been added and the information on pharmacology of bariatric medicine has been updated.

    The book addresses various dietary interventions such as low-calorie balanced diets, low-carbohydrate diets, and very-low-carbohydrate diets while also exploring the comorbidities of obesity such as hypertension, cardiovascular disease, and Type II diabetes.
    Written by prominent members of the Obesity Medicine Association and a multidisciplinary team of clinicians and researchers, the book showcases successful treatment methods by including personal key points by clinicians in each chapter. This comprehensive resource is an invaluable, user-friendly tool for bariatric physicians and surgeons, endocrinologists, diabetologists, nutritionists, and dieticians, as well as all other professionals who currently treat obesity.

  • 63500lei 580.00 lei

     Respiratory problems are the most common cause of acute admission to hospital. A variety of diagnostic investigations are required, both for acute and clinic assessment. Making Sense of Lung Function Tests, Second Edition familiarises both trainees and more experienced clinicians with the interpretation of a range of respiratory parameters. It places lung function in a clinical context using real-life examples and provides invaluable hands-on guidance.

    For this second edition Consultant Respiratory Physician Jonathan Dakin and Consultant Anaesthetist Elena Kourteli are joined by Mark Mottershaw, Chief Respiratory Physiologist from Queen Alexandra Hospital, Portsmouth, all contributing a broad range of expertise and perspectives. Together they have updated the book throughout and added new chapters including an algorithm for interpretation of pulmonary function tests, exhaled nitric oxide (FENO) and cardiopulmonary exercise testing.

    The text offers a clear explanation of the concepts which students find difficult, including:


    • The basis of obstructive and restrictive defects


    • Pattern recognition of the flow volume loop


    • Differences between TLCO and KCO


    • Assessment of oxygenation using POand SO2


    • The basis of Type 1 and type 2 respiratory failure


    • Distinguishing respiratory and metabolic acidosis


    • The relationship between sleep and respiratory failure

    The information is presented in an accessible way, suitable for those seeking a basic grounding in spirometry or blood gases, but also sufficiently comprehensive for readers completing specialist training in general or respiratory medicine.

  • 67400lei 580.00 lei

    This textbook provides a comprehensive, state-of-the art review of the field of hernia surgery, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in both inguinal and ventral/incisional hernia. This book provides an overview of the current understanding of the biologic basis of hernia formation as well as laying the foundation for the importance of hernia research and evaluating outcomes in hernia repair. Diagnosis and management strategies for inguinal and ventral hernia are discussed in detail with separate techniques sections for the most widely used procedures in this field as well as emerging technologies such a robotic and single incision surgery.

    Pertinent associated topics to inguinal hernia surgery such as chronic groin and athletic pubalgia are covered in detail. For incisional hernias, associated topics such as hernia prevention and enhanced recovery protocols are discussed. For both inguinal and ventral/incisional hernias mesh choices and available mesh technologies are discussed in detail as this remains an often confusing matter for the general surgery. When appropriate, chapters to highlight controversies in care are featured such as the use of synthetic mesh in contaminated surgery and laparoscopic closure of defects in laparoscopic ventral hernia repair.

    Current recommendations and outcomes data are highlighted when available for each technique. Textbook of Surgery will serve as a very useful resource for physicians and researchers dealing with, and interested in, abdominal wall hernias. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.

  • 580.00 lei

    This book introduces the advanced topics regarding renal failure including manifold findings of physiologic, pathophysiologic and clinical aspects in the kidney. The kidney plays a crucial physiologic role in the regulation of urinary formation, fluid balance, nutrition metabolism, blood pressure and other aspects in the living body. Renal failure is a condition of a decline or loss of kidney function due to deficiency of functioning nephrons. Acute renal failure is a syndrome, which is characterized by acute decline or loss of kidney function due to temporary disfunctioning or blocking of nephrons. Acute renal failure is a reversible condition and is a secondary manifestation, a complication of another underlying critical illness. Chronic renal failure is a condition of slow, gradual decline of kidney function due to irreversible destruction of nephrons. This book provides recent information concerning acute and chronic renal failure in clinical aspects, and is constituted in five chapters.

  • 70000lei 650.00 lei

     This new book on vascular malformations brings together international experts to present advances and discuss controversies in the multidisciplinary management of patients with congenital vascular malformations.

    Major advances in recent years in medical genetics, and tremendous progress in the fields of imaging and minimally invasive percutaneous interventions have revolutionized both evaluation and management of vascular malformations. The six major parts of this state of the art book ensure that the reader has the most up to date valuable clinical information to ensure the delivery of world class clinical practice. Beautifully illustrated with color line drawings, numerous photographs and informative tables, the advances and controversies of the full spectrum of vascular malformations are presented in 90 definitive chapters.

    Vascular Malformations brings new information and unparalleled insights to vascular specialists and physicians, trainees and allied health professionals who participate in the care of patients with vascular malformations, either in a private practice setting or at a major institution in an interdisciplinary vascular center.

    Table of Contents

    Foreword Hugo Partsch

    Preface BB Lee, Peter Gloviczki & Francine Blei

    Part 1. Congenital Vascular Malformations (CVMs) in General

    Section 1. Definition & Classification

    Chapter 1. ISSVA Classification: Controversy with the benefit and liability.

    Raul Mattassi

    Chapter 2. Hamburg Classification: Controversy with the benefit and liability.

    Peter Gloviczki & David Driscoll

    Chapter 3. Syndromic classification of Congenital Vascular Malformations: how useful is it?

    Francine Blei

    Chapter 4. Consensus on the contemporary classification.

    BB Lee & Leonel Villavicencio

    Section 2. Diagnosis

    Chapter 5. How extensive study should be included in initial assessment for the Congenital Vascular Malformations?

    BB Lee & James Laredo

    Chapter 6. Should hemangiomas be included in the initial differential diagnosis for Congenital Vascular Malformations?

    Francine Blei

    Chapter 7. How much the genetic studies should be incorporated for Venous Malformations and Arterio-Venous Malformations assessment, and when?

    Sandro Michelini, Stefano Paolacci & Matteo Bertelli

    Chapter 8. Indications for genetic testing in the evaluation of Lymphatic and Hemolymphatic Malformations.

    Stanley G. Rockson

    Section 3. Management

    Chapter 9. The importance of interdisciplinary team approach for evaluation and

    management of Vascular Malformations.

    Megha M. Tollefson, Peter Gloviczki & David Driscoll

    Chapter 10. How will genetics influence the management of Vascular Malformations?

    Francine Blei

    Part 2. Arterio-Venous Malformations (AVMs)

    Section 4. Definition & Classification

    Chapter 11. Confusion with Arterio-Venous fistula versus Arterio-Venous Malformation of ISSVA Classification.

    Dirk Loose

    Chapter 12. Nidus or no nidus: Is it a crucial issue for diagnostic assessment for the Arterio-Venous Malformations?

    Furuzan Numan

    Chapter 13. New classification of the Arterio-Venous Malformations based on arteriographic findings: How much worthy?

    YoungSoo Do & Kwang Bo Park

    Section 5. Diagnosis

    Chapter 14. Arteriographic assessment: Is it still a gold standard for the Arterio-Venous Malformations diagnosis?

    Hendrik von Tengg-Kobligk, Iris Baumgartner, Sabrina Frey & Dominik Obrist

    Chapter 15. Ultrasonographic assessment: New role for the Arterio-Venous Malformations. How far can it be implied?

    Erica Menegatti & Sergio Gianesini

    Chapter 16. Magnetic Resonance (MR) Angiography and/or Computed Tomography (CT) Angiography: New gold standard for the Arterio-Venous Malformations?

    Massimo Vaghi

    Chapter 17. Transarterial Lung Perfusion Scintigraphy (TLPS): New role for the follow up


    Raul Mattassi

    Section 6. Management - 1

    Chapter 18. Do all the Arterio-Venous Malformations mandate the therapy? Is there any contraindication for the therapy?

    BB Lee & James Laredo

    Chapter 19. How much is too much for the Arterio-Venous Malformation management?

    Young-Wook Kim

    Chapter 20. Ethanol sclerotherapy- Is it gold standard for the Arterio-Venous Malformation management?

    Iris Baumgartner, Mihai Constatntinescu, Jochen Rössler & Hendrik von Tengg

    Chapter 21. N-Butyl Cyanoacrylate versus Onyx embolotherapy.

    Furuzan Numan

    Section 7. Management - 2

    Chapter 22. Surgical therapy combined with embolo/sclerotherapy - Multidisciplinary


    Paul Marji, James Laredo & BB Lee

    Chapter 23. Indication for the amputation for the Arterio-Venous Malformation - proper option?

    Young-Wook Kim

    Chapter 24. How much pharmacological therapy can be incorporated to the Arterio-Venous Malformation management?

    Jochen Karl Rössler & Iris Baumgartner

    Chapter 25. Secondary changes in Arterio-Venous Malformations: arteries, veins, tissues, bones; when do they have to be treated?

    Dirk Loose

    Part 3. Venous Malformations (VMs)

    Section 8. Definition & Classification

    Chapter 26. (Capillary & Cavernous) Hemangioma and Venous Malformations.

    BB Lee & James Laredo

    Chapter 27. Angiographic classification of the Venous Malformations based on venous drainage status: How much worthy?

    Kwang Bo Park & Young Soo Do

    Section 9. Diagnosis

    Chapter 28. Ultrasonographic assessment: Mandatory test to lead the assessment of the Venous Malformations?

    Pier Luigi Antignani

    Chapter 29. Conventional and Dynamic Contrast Enhanced Magnetic Resonance Imaging (dceMRI) and/or Magnetic Resonance Venography: diagnostic modalities with different objectives? Can they replace phlebography?

    Jovan Markovic & Cynthia Shortell

    Chapter 30. Computed Tomography (CT) and CT Venography: how are these modalities different from Magnetic Resonance Imaging (MRI) for evaluation of Venous Malformations?

    Jovan Markovic & Cynthia Shortell

    Chapter 31. Whole Body Blood Pool Scintigraphy (WBBPS) - Special role for the management of Venous Malformations?

    Raul Mattassi

    Section 10. Management -1

    Chapter 32. Do all the Venous Malformations require treatment?

    Kurosh Parsi & Mina Kang

    Chapter 33. How much is too much for the Venous Malformations management?

    Pier Luigi Antignani

    Chapter 34. What is the first option for the Venous Malformations management?

    Sarah Bernhard, Aleksandra Tuleja, Jochen Rössler & Iris Baumgartner

    Chapter 35. Ethanol sclerotherapy- Is it gold standard for the Venous Malformations management as well?

    YoungSoo Do

    Chapter 36. Foam Sclerotherapy- First option for Venous Malformations?

    Kurosh Parsi & Mina Kang

    Chapter 37. Considerations regarding feasibility, safety and efficacy of N-Butyl Cyanoacrylate (n-BCA) and Onyx embolization for the treatment of Venous Malformations.

    Jovan Markovic & Cynthia Shortell

    Section 11. Management -2

    Chapter 38. Surgical therapy of Venous Malformations combined with embolo/sclerotherapy: How much and when?

    Dirk Loose

    Chapter 39. How aggressive the management of vascular bone syndrome caused by the Venous Malformations should be?

    Raul Mattassi

    Chapter 40. To what extent should anticoagulation therapy be considered to the Venous Malformations?

    Alfonso Tafur, Evi Kalodiki & Jawed Fareed

    Chapter 41. How to approach on Marginal Vein combined with deep vein hypoplasia/ aplasia?

    Dirk Loose

    Chapter 42. Indication for the amputation for extensive Venous Malformations - proper


    Dirk Loose

    Chapter 43. How much pharmacological therapy can be incorporated to the Venous Malformations management?

    Francine Blei

    Part 4. Lymphatic Malformations (LMs)

    Section 12. Definition & Classification

    Chapter 44. Confusion on the Terminology- Primary Lymphedema and Lymphangioma /Lymphatic Malformations

    James Laredo & BB Lee

    Chapter 45. Contemporary diagnosis of Primary Lymphedema and Lymphatic Malformations

    Stanley G. Rockson

    Chapter 46. Clinical staging of lymphedema - How practical for clinical management of

    Primary Lymphedema?

    Sandro Michelini, Alessandro Fiorentino, Alessandro Failla & Giovanni Moneta

    Chapter 47. Laboratory (lymphoscintigraphic) staging- Guideline?

    BB Lee & James Laredo

    Section 13. Diagnosis

    Chapter 48. Ultrasonographic assessment of the Lymphatic Malformations : Lymphangioma & Primary Lymphedema - A new role for the diagnosis?

    Erica Menegatti & Sergio Gianesini

    Chapter 49. Radionuclide Lymphoscintigraphy (LSG) - Gold standard for the assessment of

    the Lymphatic Malformations: Lymphangioma & Primary Lymphedema, BOTH?

    Vaughan Keeley

    Chapter 50. Magnetic Resonance Imaging (MRI) and Magnetic Resonance Lymphangiography of Primary Lymphedema - A new gold standard?

    NingFei Liu

    Chapter 51. Indocyanine Green (ICG) Fluorescent Lymphography- Clinical implementation

    Takumi Yamamoto

    Chapter 52. Oil Contrast Lymphangiography - New role for the surgical candidate?

    Francesco Boccardo, Sara Dessalvi, Campisi Corrado Cesare & Campisi Corradino

    Chapter 53. Fluorescent microlymphangiography: Controversial - confusion and neglected problems

    Claudio Allegra, Michelangelo Bartolo & Salvino Bilancini

    Chapter 54. Can Indocyanine Green (ICG) Fluorescent Lymphography replace the role of Lymphoscintigraphy (LSG)?

    Takumi Yamamoto

    Chapter 55. How to differentiate between the Lymphedema and Lipedema. How to rule out the Lipedema?

    Győző Szolnoky

    Section 14. Management- 1: Primary Lymphedema

    Chapter 56. Manual Lymphatic Drainage (MLD) - Myth?

    Isabel Forner Cordero & Jean Paul Belgrado

    Chapter 57. Compression therapy- Optimal Pressure? Bandage versus stocking.

    Isabel Forner Cordero & Jean Paul Belgrado

    Chapter 58. Sequential Intermittent Pneumatic Compression (SIPC) - Rationale? How much it can be incorporated to compression therapy?

    Isabel Forner Cordero & Jean Paul Belgrado

    Chapter 59. Reconstructive surgery: Lymphovenous anastomosis versus lymph-node transplantation. Can they stay as an independent therapy option? Indications & Contraindications?

    Corradino Campisi, Francesco Boccardo, Melissa Ryan, Michele Maruccia, Fabio Nicoli, Pietro Di Summa & Corrado Cesare Campisi

    Chapter 60. Excisional surgery: when and how much it can be incorporated?

    Justin Chin-Bong Choi, James Laredo & BB Lee

    Chapter 61. Multidisciplinary approach with liposuction in Primary Lymphedema: Is there a difference compared to patients with Secondary Lymphedema?

    Robert Damstra & Håkan Brorson

    Chapter 62. How much pharmacological therapy can be incorporated to the Primary Lymphedema management?

    Vaughan Keeley and Neil Piller

    Chapter 63. What is the difference in the management of Primary Lymphedema between the

    adults and children, and how much?

    Miguel Amore & Cristobal Papendieck

    Chapter 64. How to manage the Lipedema involved to Primary lymphedema?

    Győző Szolnoky

    Chapter 65. How to assess the response/efficacy of manual lymphatic drainage and

    compression therapy.

    Győző Szolnoky

    Chapter 66. How to assess the efficacy of Lipedema management involved to the


    Győző Szolnoky

    Chapter 67. The pathophysiology behind adipose tissue deposition in Lymphedema and how

    liposuction completely can reduce the excess volume

    Håkan Brorson

    Chapter 68. Liposuction- can it be implied to the management of Lipedema?

    Robert Damstra & Tobias Bertsch

    Section 15. Management-2 : Lymphangioma

    Chapter 69. How to manage the lymphatic leakage involved in Lymphangioma?

    Xi Yang, Xiaoxi Lin & NingFei Liu,

    Chapter 70. How to manage recurrent infections involved to Lymphangioma?

    Xi Yang, Xiaoxi Lin MD &NingFei Liu

    Chapter 71. How aggressive chyloreflux (e.g. chyluria, chyloascites, chylothorax, chyle-

    leakage) should be handled?

    Miguel Amore & Cristobal Papendieck

    Chapter 72. Pharmacological considerations for Lymphatic Malformation management

    Stanley G. Rockson

    Chapter 73. How much different the management of Lymphangioma among

    pediatric/neonatal age group should be?

    Miguel Amore & Cristobal Papendieck

    Chapter 74. Peculiarities in surgical treatment in childhood; can we ignore?

    Juan Carlos López Gutiérrez

    Part 5. Combined vascular malformations: Hemo-lymphatic

    Malformations / Klippel-Trenaunay Syndrome (KTS)

    Section 16. Diagnosis

    Chapter 75. What extent the diagnostic study should be extended for the Arterio-Venous Malformations involvement to Klippel-Trenaunay Syndrome assessment?

    Massimo Vaghi

    Chapter 76. How much the diagnostic investigations should incorporate visceral

    involvement for Klippel-Trenaunay Syndrome?

    Massimo Vaghi

    Section 17. Management -1

    Chapter 77. How to decide the priority for the treatment among the Congenital Vascular Malformation components?

    James Laredo & BB Lee

    Chapter 78. The management of Vascular Bone Syndrome: how aggressive and when?

    Jong Sup Shim & Young-Wook Kim

    Chapter 79. How aggressive to manage the varicose veins involved to Klippel-Trenaunay Syndrome?

    Sergio Gianesini and Erica Menegatti

    Chapter 80. How aggressive the management of the indolent stasis ulcer should be done

    in Klippel-Trenaunay Syndrome?

    Sergio Gianesini & Erica Menegatti

    Section 18. Management -2

    Chapter 81. How aggressive the gastrointestinal bleeding among Klippel-Trenaunay Syndrome should be handled?

    Massimo Vaghi

    Chapter 82. Therapeutic considerations for infection, sepsis and lymphatic leak management in patients with Klippel-Trenaunay Syndrome

    Jovan Markovic & Cynthia Shortell

    Chapter 83. How to manage the coagulopathy in Klippel-Trenaunay Syndrome?

    Alfonso Tafur, Evi Kalodiki & Jawed Fareed

    Chapter 84. Klippel-Trenaunay Syndrome: Pain and Psychosocial Considerations

    Jamison Harvey, Megha Tollefson, Peter Gloviczki & David Driscoll

    Chapter 85. Klippel-Trenaunay Syndrome and Complex Venous Malformations: Should a multi-modality approach be the standard of care? - Endovenous Laser Ablation (EVLA), Tumescent-assisted Ultrasound-Guided Sclerotherapy (TUGS), n-BCA and Power Phlebectomy.

    Kurosh Parsi & Mina Kang

    Part 6. Capillary Malformations (CMs)

    Section 19. Diagnosis

    Chapter 86. Is this a Capillary Malformation? - Differential diagnosis and other dermal vascular lesions and eruptions.

    Kurosh Parsi & Mina Kang

    Chapter 87. How much the diagnostic assessment for Port Wine Stains should be extended for other Vascular Malformations to exist together?



  • 80000lei 690.00 lei



    MASTER MODERN MEDICINE! Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible. Essential for practice and education, the landmark 20th Edition features: Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care. State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals. All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine—Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine. Important and timely new chapters—such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more—offer the very latest, definitive perspectives on must-know topics in medical education and practice. Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes. End-of-chapter suggested readings reinforce the text material and provide a robust platform for further study and research.


    Table of Contents:

    PART 1 The Profession of Medicine

    1 The Practice of Medicine

    2 Promoting Good Health

    3 Decision-Making in Clinical Medicine

    4 Screening and Prevention of Disease

    5 Health Care Systems in Developed Countries

    6 The Safety and Quality of Health Care

    7 Racial and Ethnic Disparities in Health Care

    8 Ethical Issues in Clinical Medicine

    9 Palliative and End-of-Life Care

    PART 2 Cardinal Manifestations and Presentation of Diseases

    SECTION 1 Pain

    10 Pain: Pathophysiology and Management

    11 Chest Discomfort

    12 Abdominal Pain

    13 Headache

    14 Back and Neck Pain

    SECTION 2 Alterations in Body Temperature

    15 Fever

    16 Fever and Rash

    17 Fever of Unknown Origin

    SECTION 3 Nervous System Dysfunction

    18 Syncope

    19 Dizziness and Vertigo

    20 Fatigue

    21 Neurologic Causes of Weakness and Paralysis

    22 Numbness, Tingling, and Sensory Loss

    23 Gait Disorders, Imbalance, and Falls

    24 Confusion and Delirium

    25 Dementia

    26 Aphasia, Memory Loss, Hemispatial Neglect, Frontal Syndromes, and Other Cerebral Disorders

    27 Sleep Disorders

    SECTION 4 Disorders of Eyes, Ears, Nose, and Throat

    28 Disorders of the Eye

    29 Disorders of Smell and Taste

    30 Disorders of Hearing

    31 Sore Throat, Earache, and Upper Respiratory Symptoms

    32 Oral Manifestations of Disease

    SECTION 5 Alterations in Circulatory and Respiratory Functions

    33 Dyspnea

    34 Cough

    35 Hemoptysis

    36 Hypoxia and Cyanosis

    37 Edema

    38 Approach to the Patient with a Heart Murmur

    39 Palpitations

    SECTION 6 Alterations in Gastrointestinal Function

    40 Dysphagia

    41 Nausea, Vomiting, and Indigestion

    42 Diarrhea and Constipation

    43 Unintentional Weight Loss

    44 Gastrointestinal Bleeding

    45 Jaundice

    46 Abdominal Swelling and Ascites

    SECTION 7 Alterations in Renal and Urinary Tract Function

    47 Dysuria, Bladder Pain, and the Interstitial Cystitis/Bladder Pain Syndrome

    48 Azotemia and Urinary Abnormalities

    49 Fluid and Electrolyte Disturbances

    50 Hypercalcemia and Hypocalcemia

    51 Acidosis and Alkalosis

    SECTION 8 Alterations in the Skin

    52 Approach to the Patient with a Skin Disorder

    53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders

    54 Skin Manifestations of Internal Disease

    55 Immunologically Mediated Skin Diseases

    56 Cutaneous Drug Reactions

    57 Photosensitivity and Other Reactions to Light

    SECTION 9 Hematologic Alterations

    58 Interpreting Peripheral Blood Smears

    59 Anemia and Polycythemia

    60 Disorders of Granulocytes and Monocytes

    61 Bleeding and Thrombosis

    62 Enlargement of Lymph Nodes and Spleen

    PART 3 Pharmacology

    63 Principles of Clinical Pharmacology

    64 Pharmacogenomics

    PART 4 Oncology and Hematology

    SECTION 1 Neoplastic Disorders

    65 Approach to the Patient with Cancer

    66 Prevention and Early Detection of Cancer

    67 Cancer Genetics

    68 Cancer Cell Biology

    69 Principles of Cancer Treatment

    70 Infections in Patients with Cancer

    71 Oncologic Emergencies

    72 Cancer of the Skin

    73 Head and Neck Cancer

    74 Neoplasms of the Lung

    75 Breast Cancer

    76 Upper Gastrointestinal Tract Cancers

    77 Lower Gastrointestinal Cancers

    78 Tumors of the Liver and Biliary Tree

    79 Pancreatic Cancer

    80 Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas

    81 Renal Cell Carcinoma

    82 Cancer of the Bladder and Urinary Tract

    83 Benign and Malignant Diseases of the Prostate

    84 Testicular Cancer

    85 Gynecologic Malignancies

    86 Primary and Metastatic Tumors of the Nervous System

    87 Soft Tissue and Bone Sarcomas and Bone Metastases

    88 Carcinoma of Unknown Primary

    89 Paraneoplastic Syndromes: Endocrinologic/Hematologic

    90 Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis

    91 Late Consequences of Cancer and Its Treatment

    SECTION 2 Hematopoietic Disorders

    92 Hematopoietic Stem Cells

    93 Iron Deficiency and Other Hypoproliferative Anemias

    94 Disorders of Hemoglobin

    95 Megaloblastic Anemias

    96 Hemolytic Anemias

    97 Anemia Due to Acute Blood Loss

    98 Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia

    99 Polycythemia Vera and Other Myeloproliferative Neoplasms

    100 Acute Myeloid Leukemia

    101 Chronic Myeloid Leukemia

    102 Acute Lymphoid Leukemia

    103 Chronic Lymphocytic Leukemia

    104 Non-Hodgkin’s Lymphoma

    105 Hodgkin’s Lymphoma

    106 Less Common Hematologic Malignancies

    107 Plasma Cell Disorders

    108 Amyloidosis

    109 Transfusion Biology and Therapy

    110 Hematopoietic Cell Transplantation

    SECTION 3 Disorders of Hemostasis

    111 Disorders of Platelets and Vessel Wall

    112 Coagulation Disorders

    113 Arterial and Venous Thrombosis

    114 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs

    PART 5 Infectious Diseases

    SECTION 1 Basic Considerations in Infectious Diseases

    115 Approach to the Patient with an Infectious Disease

    116 Molecular Mechanisms of Microbial Pathogenesis

    117 Approach to the Acutely Ill Infected Febrile Patient

    118 Immunization Principles and Vaccine Use

    119 Health Recommendations for International Travel

    120 Climate Change and Infectious Disease

    SECTION 2 Clinical Syndromes: Community-Acquired Infections

    121 Pneumonia

    122 Lung Abscess

    123 Infective Endocarditis

    124 Infections of the Skin, Muscles, and Soft Tissues

    125 Infectious Arthritis

    126 Osteomyelitis

    127 Intraabdominal Infections and Abscesses

    128 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning

    129 Clostridium difficile Infection, Including Pseudomembranous Colitis

    130 Urinary Tract Infections, Pyelonephritis, and Prostatitis

    131 Sexually Transmitted Infections: Overview and Clinical Approach

    132 Encephalitis

    133 Acute Meningitis

    134 Chronic and Recurrent Meningitis

    135 Brain Abscess and Empyema

    136 Infectious Complications of Bites

    SECTION 3 Clinical Syndromes: Health Care–Associated Infections

    137 Infections Acquired in Health Care Facilities

    138 Infections in Transplant Recipients

    SECTION 4 Therapy for Bacterial Diseases

    139 Treatment and Prophylaxis of Bacterial Infections

    140 Bacterial Resistance to Antimicrobial Agents

    SECTION 5 Diseases Caused by Gram-Positive Bacteria

    141 Pneumococcal Infections

    142 Staphylococcal Infections

    143 Streptococcal Infections

    144 Enterococcal Infections

    145 Diphtheria and Other Corynebacterial Infections

    146 Listeria monocytogenes Infections

    147 Tetanus

    148 Botulism

    149 Gas Gangrene and Other Clostridial Infections

    SECTION 6 Diseases Caused by Gram-Negative Bacteria

    150 Meningococcal Infections

    151 Gonococcal Infections

    152 Haemophilus and Moraxella Infections

    153 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria

    154 Legionella Infections

    155 Pertussis and Other Bordetella Infections

    156 Diseases Caused by Gram-Negative Enteric Bacilli

    157 Acinetobacter Infections

    158 Helicobacter pylori Infections

    159 Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species

    160 Salmonellosis

    161 Shigellosis

    162 Infections Due to Campylobacter and Related Organisms

    163 Cholera and Other Vibrioses

    164 Brucellosis

    165 Tularemia

    166 Plague and Other Yersinia Infections

    167 Bartonella Infections, Including Cat-Scratch Disease

    168 Donovanosis

    SECTION 7 Miscellaneous Bacterial Infections

    169 Nocardiosis

    170 Actinomycosis

    171 Whipple’s Disease

    172 Infections Due to Mixed Anaerobic Organisms

    SECTION 8 Mycobacterial Diseases

    173 Tuberculosis

    174 Leprosy

    175 Nontuberculous Mycobacterial Infections

    176 Antimycobacterial Agents

    SECTION 9 Spirochetal Diseases

    177 Syphilis

    178 Endemic Treponematoses

    179 Leptospirosis

    180 Relapsing Fever

    181 Lyme Borreliosis

    SECTION 10 Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae

    182 Rickettsial Diseases

    183 Infections Due to Mycoplasmas

    184 Chlamydial Infections

    SECTION 11 Viral Diseases: General Considerations

    185 Medical Virology

    186 Antiviral Chemotherapy, Excluding Antiretroviral Drugs

    SECTION 12 Infections Due to DNA Viruses

    187 Herpes Simplex Virus Infections

    188 Varicella-Zoster Virus Infections

    189 Epstein-Barr Virus Infections, Including Infectious Mononucleosis

    190 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8

    191 Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections

    192 Parvovirus Infections

    193 Human Papillomavirus Infections

    SECTION 13 Infections Due to DNA and RNA Respiratory Viruses

    194 Common Viral Respiratory Infections

    195 Influenza

    SECTION 14 Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses

    196 The Human Retroviruses

    197 Human Immunodeficiency Virus Disease: AIDS and Related Disorders

    SECTION 15 Infections Due to RNA Viruses

    198 Viral Gastroenteritis

    199 Enterovirus, Parechovirus, and Reovirus Infections

    200 Measles (Rubeola)

    201 Rubella (German Measles)

    202 Mumps

    203 Rabies and Other Rhabdovirus Infections

    204 Arthropod-Borne and Rodent-Borne Virus Infections

    205 Ebolavirus and Marburgvirus Infections

    SECTION 16 Fungal Infections

    206 Diagnosis and Treatment of Fungal Infections

    207 Histoplasmosis

    208 Coccidioidomycosis

    209 Blastomycosis

    210 Cryptococcosis

    211 Candidiasis

    212 Aspergillosis

    213 Mucormycosis

    214 Superficial Mycoses and Less Common Systemic Mycoses

    215 Pneumocystis Infections

    SECTION 17 Protozoal and Helminthic Infections: General Considerations

    216 Introduction to Parasitic Infections

    217 Agents Used to Treat Parasitic Infections

    SECTION 18 Protozoal Infections

    218 Amebiasis and Infection with Free-Living Amebae

    219 Malaria

    220 Babesiosis

    221 Leishmaniasis

    222 Chagas Disease and African Trypanosomiasis

    223 Toxoplasma Infections

    224 Protozoal Intestinal Infections and Trichomoniasis

    SECTION 19 Helminthic Infections

    225 Introduction to Helminthic Infections

    226 Trichinellosis and Other Tissue Nematode Infections

    227 Intestinal Nematode Infections

    228 Filarial and Related Infections

    229 Schistosomiasis and Other Trematode Infections

    230 Cestode Infections

    PART 6 Disorders of the Cardiovascular System

    SECTION 1 Introduction to Cardiovascular Disorders

    231 Approach to the Patient with Possible Cardiovascular Disease

    232 Basic Biology of the Cardiovascular System

    233 Epidemiology of Cardiovascular Disease

    SECTION 2 Diagnosis of Cardiovascular Disorders

    234 Physical Examination of the Cardiovascular System

    235 Electrocardiography

    236 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging

    237 Diagnostic Cardiac Catheterization and Coronary Angiography

    SECTION 3 Disorders of Rhythm

    238 Principles of Electrophysiology

    239 The Bradyarrhythmias: Disorders of the Sinoatrial Node

    240 The Bradyarrhythmias: Disorders of the Atrioventricular Node

    241 Approach to Supraventricular Tachyarrhythmias

    242 Physiologic and Nonphysiologic Sinus Tachycardia

    243 Focal Atrial Tachycardia

    244 Paroxysmal Supraventricular Tachycardias

    245 Common Atrial Flutter, Macroreentrant, and Multifocal Atrial Tachycardias

    246 Atrial Fibrillation

    247 Approach to Ventricular Arrhythmias

    248 Premature Ventricular Beats, Non-Sustained Ventricular Tachycardia, and Idioventricular Rhythm

    249 Sustained Ventricular Tachycardia

    250 Polymorphic Ventricular Tachycardia and Ventricular Fibrillation

    251 Electrical Storm and Incessant VT

    SECTION 4 Disorders of the Heart

    252 Heart Failure: Pathophysiology and Diagnosis

    253 Heart Failure: Management

    254 Cardiomyopathy and Myocarditis

    255 Cardiac Transplantation and Prolonged Assisted Circulation

    256 Aortic Valve Disease

    257 Aortic Regurgitation

    258 Mitral Stenosis

    259 Mitral Regurgitation

    260 Mitral Valve Prolapse

    261 Tricuspid Valve Disease

    262 Pulmonic Valve Disease

    263 Multiple and Mixed Valvular Heart Disease

    264 Congenital Heart Disease in the Adult

    265 Pericardial Disease

    266 Atrial Myxoma and Other Cardiac Tumors

    SECTION 5 Coronary and Peripheral Vascular Disease

    267 Ischemic Heart Disease

    268 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina)

    269 ST-Segment Elevation Myocardial Infarction

    270 Percutaneous Coronary Interventions and Other Interventional Procedures

    271 Hypertensive Vascular Disease

    272 Renovascular Disease

    273 Deep Venous Thrombosis and Pulmonary Thromboembolism

    274 Diseases of the Aorta

    275 Arterial Diseases of the Extremities

    276 Chronic Venous Disease and Lymphedema

    277 Pulmonary Hypertension

    PART 7 Disorders of the Respiratory System

    SECTION 1 Diagnosis of Respiratory Disorders

    278 Approach to the Patient with Disease of the Respiratory System

    279 Disturbances of Respiratory Function

    280 Diagnostic Procedures in Respiratory Disease

    SECTION 2 Diseases of the Respiratory System

    281 Asthma

    282 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia

    283 Occupational and Environmental Lung Disease

    284 Bronchiectasis

    285 Cystic Fibrosis

    286 Chronic Obstructive Pulmonary Disease

    287 Interstitial Lung Disease

    288 Disorders of the Pleura

    289 Disorders of the Mediastinum

    290 Disorders of Ventilation

    291 Sleep Apnea

    292 Lung Transplantation

    PART 8 Critical Care Medicine

    SECTION 1 Respiratory Critical Care

    293 Approach to the Patient with Critical Illness

    294 Acute Respiratory Distress Syndrome

    295 Mechanical Ventilatory Support

    SECTION 2 Shock and Cardiac Arrest

    296 Approach to the Patient with Shock

    297 Sepsis and Septic Shock

    298 Cardiogenic Shock and Pulmonary Edema

    299 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death

    SECTION 3 Neurologic Critical Care

    300 Coma

    301 Severe Acute Encephalopathies and Critical Care Weakness

    302 Subarachnoid Hemorrhage

    PART 9 Disorders of the Kidney and Urinary Tract

    303 Cellular and Molecular Biology of the Kidney

    304 Acute Kidney Injury

    305 Chronic Kidney Disease

    306 Dialysis in the Treatment of Renal Failure

    307 Transplantation in the Treatment of Renal Failure

    308 Glomerular Diseases

    309 Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development

    310 Tubulointerstitial Diseases of the Kidney

    311 Vascular Injury to the Kidney

    312 Nephrolithiasis

    313 Urinary Tract Obstruction

    PART 10 Disorders of the Gastrointestinal System

    SECTION 1 Disorders of the Alimentary Tract

    314 Approach to the Patient with Gastrointestinal Disease

    315 Gastrointestinal Endoscopy

    316 Diseases of the Esophagus

    317 Peptic Ulcer Disease and Related Disorders

    318 Disorders of Absorption

    319 Inflammatory Bowel Disease

    320 Irritable Bowel Syndrome

    321 Diverticular Disease and Common Anorectal Disorders

    322 Mesenteric Vascular Insufficiency

    323 Acute Intestinal Obstruction

    324 Acute Appendicitis and Peritonitis

    SECTION 2 Nutrition

    325 Nutrient Requirements and Dietary Assessment

    326 Vitamin and Trace Mineral Deficiency and Excess

    327 Malnutrition and Nutritional Assessment

    328 Enteral and Parenteral Nutrition

    SECTION 3 Liver and Biliary Tract Disease

    329 Approach to the Patient with Liver Disease

    330 Evaluation of Liver Function

    331 The Hyperbilirubinemias

    332 Acute Viral Hepatitis

    333 Toxic and Drug-Induced Hepatitis

    334 Chronic Hepatitis

    335 Alcoholic Liver Disease

    336 Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis

    337 Cirrhosis and Its Complications

    338 Liver Transplantation

    339 Diseases of the Gallbladder and Bile Ducts

    SECTION 4 Disorders of the Pancreas

    340 Approach to the Patient with Pancreatic Disease

    341 Acute and Chronic Pancreatitis

    PART 11 Immune-Mediated, Inflammatory, and Rheumatologic Disorders

    SECTION 1 The Immune System in Health and Disease

    342 Introduction to the Immune System

    343 The Major Histocompatibility Complex

    344 Primary Immune Deficiency Diseases

    SECTION 2 Disorders of Immune-Mediated Injury

    345 Urticaria, Angioedema, and Allergic Rhinitis

    346 Anaphylaxis

    347 Mastocytosis

    348 Autoimmunity and Autoimmune Diseases

    349 Systemic Lupus Erythematosus

    350 Antiphospholipid Syndrome

    351 Rheumatoid Arthritis

    352 Acute Rheumatic Fever

    353 Systemic Sclerosis (Scleroderma) and Related Disorders

    354 Sjögren’s Syndrome

    355 The Spondyloarthritides

    356 The Vasculitis Syndromes

    357 Behçet’s Syndrome

    358 Inflammatory Myopathies

    359 Relapsing Polychondritis

    360 Sarcoidosis

    361 IgG4-Related Disease

    362 Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases

    SECTION 3 Disorders of the Joints and Adjacent Tissues

    363 Approach to Articular and Musculoskeletal Disorders

    364 Osteoarthritis

    365 Gout and Other Crystal-Associated Arthropathies

    366 Fibromyalgia

    367 Arthritis Associated with Systemic Disease, and Other Arthritides

    368 Periarticular Disorders of the Extremities

    PART 12 Endocrinology and Metabolism

    SECTION 1 Endocrinology

    369 Approach to the Patient with Endocrine Disorders

    370 Mechanisms of Hormone Action

    371 Physiology of Anterior Pituitary Hormones

    372 Hypopituitarism

    373 Pituitary Tumor Syndromes

    374 Disorders of the Neurohypophysis

    375 Thyroid Gland Physiology and Testing

    376 Hypothyroidism

    377 Hyperthyroidism

    378 Thyroid Nodular Disease and Thyroid Cancer

    379 Disorders of the Adrenal Cortex

    380 Pheochromocytoma

    381 Multiple Endocrine Neoplasia

    382 Autoimmune Polyendocrine Syndromes

    SECTION 2 Sex- and Gender-Based Medicine

    383 Disorders of Sex Development

    384 Disorders of the Testes and Male Reproductive System

    385 Disorders of the Female Reproductive System

    386 Menstrual Disorders and Pelvic Pain

    387 Hirsutism

    388 Menopause and Postmenopausal Hormone Therapy

    389 Infertility and Contraception

    390 Sexual Dysfunction

    391 Women’s Health

    392 Men’s Health

    393 Lesbian, Gay, Bisexual, and Transgender (LGBT) Health

    SECTION 3 Obesity, Diabetes Mellitus, and Metabolic Syndrome

    394 Pathobiology of Obesity

    395 Evaluation and Management of Obesity

    396 Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology

    397 Diabetes Mellitus: Management and Therapies

    398 Diabetes Mellitus: Complications

    399 Hypoglycemia

    400 Disorders of Lipoprotein Metabolism

    401 The Metabolic Syndrome

    SECTION 4 Disorders of Bone and Mineral Metabolism

    402 Bone and Mineral Metabolism in Health and Disease

    403 Disorders of the Parathyroid Gland and Calcium Homeostasis

    404 Osteoporosis

    405 Paget’s Disease and Other Dysplasias of Bone

    SECTION 5 Disorders of Intermediary Metabolism

    406 Heritable Disorders of Connective Tissue

    407 Hemochromatosis

    408 Wilson’s Disease

    409 The Porphyrias

    410 Disorders of Purine and Pyrimidine Metabolism

    411 Lysosomal Storage Diseases

    412 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism

    413 Inherited Disorders of Amino Acid Metabolism in Adults

    414 Inherited Defects of Membrane Transport

    PART 13 Neurologic Disorders

    SECTION 1 Diagnosis of Neurologic Disorders

    415 Approach to the Patient with Neurologic Disease

    416 Neuroimaging in Neurologic Disorders

    417 Pathobiology of Neurologic Diseases

    SECTION 2 Diseases of the Central Nervous System

    418 Seizures and Epilepsy

    419 Cerebrovascular Diseases

    420 Ischemic Stroke

    421 Intracranial Hemorrhage

    422 Migraine and Other Primary Headache Disorders

    423 Alzheimer’s Disease

    424 Frontotemporal Dementia

    425 Vascular Dementia

    426 Dementia with Lewy Bodies

    427 Parkinson’s Disease

    428 Tremor, Chorea, and Other Movement Disorders

    429 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases

    430 Prion Diseases

    431 Ataxic Disorders

    432 Disorders of the Autonomic Nervous System

    433 Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders

    434 Diseases of the Spinal Cord

    435 Concussion and Other Traumatic Brain Injuries

    436 Multiple Sclerosis

    437 Neuromyelitis Optica

    SECTION 3 Nerve and Muscle Disorders

    438 Peripheral Neuropathy

    439 Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies

    440 Myasthenia Gravis and Other Diseases of the Neuromuscular Junction

    441 Muscular Dystrophies and Other Muscle Diseases

    SECTION 4 Chronic Fatigue Syndrome

    442 Chronic Fatigue Syndrome

    SECTION 5 Psychiatric and Addiction Disorders

    443 Biology of Psychiatric Disorders

    444 Psychiatric Disorders

    445 Alcohol and Alcohol Use Disorders

    446 Opioid-Related Disorders

    447 Cocaine and Other Commonly Used Drugs

    448 Nicotine Addiction

    PART 14 Poisoning, Drug Overdose, and Envenomation

    449 Heavy Metal Poisoning

    450 Poisoning and Drug Overdose

    451 Disorders Caused by Venomous Snakebites and Marine Animal Exposures

    452 Ectoparasite Infestations and Arthropod Injuries

    PART 15 Disorders Associated with Environmental Exposures

    453 Altitude Illness

    454 Hypothermia and Peripheral Cold Injuries

    455 Heat-Related Illnesses

    PART 16 Genes, the Environment, and Disease

    456 Principles of Human Genetics

    457 The Practice of Genetics in Clinical Medicine

    458 Gene and Cell Based Therapy in Clinical Medicine

    459 The Human Microbiome

    PART 17 Global Medicine

    460 Global Issues in Medicine

    461 Worldwide Changes in Patterns of Infectious Disease

    462 Primary Care and Global Health

    PART 18 Aging

    463 The Biology of Aging

    464 Clinical Problems Associated with the Aging Process

    PART 19 Consultative Medicine

    465 Approach to Medical Consultation

    466 Medical Disorders During Pregnancy

    467 Medical Evaluation of the Surgical Patient

    PART 20 Frontiers

    468 Behavioral Economics and Health

    469 Complementary, Alternative, and Integrative Health Approaches

    470 Telomere Disease

    471 The Role of Epigenetics in Disease and Treatment

    472 Mitochondrial DNA and Heritable Traits and Diseases

    473 Applications of Stem Cell Biology in Clinical Medicine

    474 Microbial Genomics and Infectious Disease

    475 The Role of Circadian Biology in Health and Disease

    476 Network Medicine: Systems Biology in Health and Disease

    477 Emerging Neurotherapeutic Technologies



  • Respiratory Treatment and Prevention
    La comanda in aproximativ 4 saptamani
    78600lei 720.00 lei

    The goal of this book is to further insight into the challenges related to respiratory health. Medical experts present their lines of scientific investigations on how to contain the disease, care for patients, and use preventive measures, with a focus on pulmonary-related disorders. Progress in the diagnostics and treatment of major infectious diseases affecting humanity such as tuberculosis, malaria, fungal and viral contagions is tackled. Other chapters provide some background information on the mechanisms and prevention of non-communicable diseases. New aspects of the etiology of sarcoidosis, air pollution-related lung cancer, and sleep disordered breathing are presented. Preventive measures of health in general and respiratory health in particular cannot do without a reminder of cigarette smoke avoidance and the respiratory aftermath of the smoking habit. The book presents scientific evidence-based practice knowledge. It is intended for healthcare professionals, specifically pulmonary specialists, primary care physicians, and all scientifically-minded individuals involved in the care of patients.

  • 94500lei 800.00 lei



    A valuable new reference in the diagnosis and image-guided treatment of congenital heart defects

    Congenital heart defects represent the most common birth defect and affect millions of children worldwide.

    Defects of the heart and great vessels span a broad spectrum. Modern medical progress has enabled more than 90% of patients to reach adulthood. In many cases, however, patients remain ill throughout their lives, with significant limits on quality of life and physical capacity. Our ongoing goals are to improve treatment options even further.

    This book details all important imaging techniques for diagnosing congenital heart defects and assessing their severity. The author is a highly experienced expert in his field, making his clinical experience available to readers who can then implement that knowledge in their own daily routine.

    Key Features:

    ·         All key imaging modalities, including 2D and 3D echocardiography, cardiac catheter exams, MRI and MR angiography, CT, and chest X-ray

    ·         Descriptions of general and technical fundamentals, a structure based on clinical pictures, and current standard values

    ·         Crucial information emphasized in callout boxes and tabular overviews

    ·         Supports the professional dialogue between all the involved caretakers

    ·         Richly illustrated with more than 1,000 stunning images from the newest generation of devices

    Gutberlet's Diagnostic Imaging of Congenital Heart Defects: Diagnosis and Image-Guided Treatment will be welcomed by pediatric and general radiologists as a comprehensive, multimodality guide to the diagnosis and management of congenital heart defects.

    This book includes complimentary access to a digital copy on

    Table of Contents:


    1 Cardiogenesis and Classification of Congenital Heart Defects

    2 Surgical Treatment for Congenital Heart Defects

    3 Technical Basics of Diagnostic and Interventional Imaging

    4 Clinical Pictures

    5 Standard Values and Formulas



  • Microvascular Disease in Diabetes
    La comanda in aproximativ 4 saptamani
    87000lei 800.00 lei


    Presents comprehensive coverage of the many microvascular complications of diabetes

    Diabetes remains one of the main causes, in the western world, of legal blindness, end stage renal disease, and amputation, despite the implementation of tight glycemic control and the great progress in the management and care of our patients. This book provides a useful and handy tool to professionals and students in the field of diabetes and its microvascular complications by integrating information from clinical settings as well as from the frontlines of diabetic research. It provides readers with up-to-date diagnostic criteria, classifications, and therapeutic approaches. and recent discoveries on mechanisms of disease, experimental therapeutic agents, and biomarkers of disease. 

    Written by top experts in the field, Microvascular Disease in Diabetes offers in-depth chapters covering pathophysiology; the genetics of diabetic microvascular disease; and the epigenetics of diabetic microvascular disease. It then provides sections featuring both clinical and research information on diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, and diabetic foot. It also looks at coronary microvascular dysfunction and cerebral microvascular disease.

    ·         Integrates new and accessible material on diabetic microvascular comorbidities

    ·         Covers all relevant microvascular systems

    ·         Provides a much-needed resource synthesizing research and clinical applications to treating microvascular complications of diabetes

    ·         Presents current diagnostic criteria, classifications, and therapeutic approaches, as well as recent discoveries on the mechanisms of disease, experimental therapeutic agents, and biomarkers of disease

    Assembled in an easily consultable manner, Microvascular Disease in Diabetes is an excellent text for investigators, clinicians, and students looking to improve their understanding of diabetic complications.


    FRANCESCO TECILAZICH, MD, PhD, is a physician and scientist in the Endocrinology and Metabolic Diseases department of the Ospedale San Raffaele—Vita Salute San Raffaele University in Milan, Italy.


    Foreword to: Microvascular Disease in Diabetes xv

    Editor Biography xvii

    List of Contributors xix

    1 Introduction 1
    Andrea Giustina and Stefano Frara

    References 3

    2 Pathophysiology 5
    Francesco Tecilazich

    Introduction 5

    Anatomo-Physiology of Microvessels 5

    Regulation of Microvascular Tone 6

    Endothelial-Dependent Vasodilation 6

    Endothelial-Independent Vasodilation 6

    Nerve Axon Reflex (NARV) 7

    Myogenic Response 7

    Functional Hyperemia 7

    Venoarteriolar Response (VAR) 8

    Structural Changes in the Microcirculation 8

    Functional Changes in the Microcirculation 8

    Endothelial Dysfunction 8

    VSMC Dysfunction 9

    NARV Impairment 9

    Defective Myogenic Response 10

    Reduced Functional Hyperemia 10

    Endothelial Dysfunction 11

    Role of the Immune System and Leukostasis 11

    Role of Hyperglycemia 12

    AGEs 12

    Polyol Pathway 12

    Oxidative Stress 13

    PKC 13

    Transforming Growth Factor (TGF)-β 14

    Hexosamine Pathway 14

    PARP 14

    ET-1 14

    Vasoconstrictor Prostanoid Synthesis 15

    Role of Insulin Resistance 15

    Role of Inflammation 15

    References 16

    3 Genetics of Diabetic Microvascular Disease 23
    Niina Sandholm and Carol Forsblom

    Introduction 23

    Genetics of DKD 23

    Heritability of DKD 23

    Candidate Genes for DKD 24

    Linkage Studies for DKD 25

    Genome-Wide Association Studies on DKD 25

    Sequencing Efforts for DKD 29

    Genetics of Diabetic Retinopathy 30

    Heritability of Diabetic Retinopathy 30

    Candidate Genes for Diabetic Retinopathy 30

    Linkage Studies for Diabetic Retinopathy 31

    GWAS on Diabetic Retinopathy 31

    Sequencing Efforts for Diabetic Retinopathy 33

    Genetics of Diabetic Neuropathy 33

    Heritability of Diabetic Neuropathy 33

    Candidate Genes for Diabetic Neuropathy 33

    GWASs on Diabetic Neuropathy 34

    Future Directions 34

    Larger Studies are Needed 34

    How to Define the Phenotype? 35

    Variability in the Phenotypic Definitions 35

    Criteria for Controls 36

    Do Genetics of Microvascular Complications in T1D and T2D Differ? 36

    Low-Frequency and Rare Variants May Affect Diabetic Complications 36

    Sequencing of Rare and Low-Frequency Variants 36

    Linkage Analysis with GWAS Data 37

    Genetics May Reveal Biology and Infer Causality 37

    Conclusions 37

    References 37

    4 Epigenetics of Diabetic Microvascular Disease 45
    Luciano Pirola

    Diabetic Complications Include Microvascular and Macrovascular Injury 45

    The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study in Type 1 Diabetic Patients, and the UKPDS Study in Type 2 Diabetic Patients, Support the Existence of the Hyperglycemic Memory Phenomenon 46

    DCCT/EDIC Study 46

    The UKPDS Study 46

    Models of Hyperglycemic Memory 47

    Animal Models 47

    Cell Culture Models 48

    The “Epigenetic Code” 48

    DNA Methylation 49

    Histone Methylation in Models of Hyperglycemic Variability 49

    Epigenetic Changes in Microvascular Models of Glycemic Memory 50

    MiRNAs Contribute to the Control of Glucose Homeostasis and are Dysregulated in Diabetes 52

    Future Prospects 52

    References 54

    5 Diabetic Retinopathy – Clinical 59
    Francesco Bandello, Rosangela Lattanzio, Alessandro Marchese, and Emanuela Aragona

    Introduction 59

    Epidemiology 60

    Screening 60

    Risk Factors 61

    Clinical Patterns 61

    Non-Proliferative Diabetic Retinopathy (NPDR) 61

    Clinical Findings 62

    Diagnostic Tools 64

    Treatment Strategies 65

    Proliferative Diabetic Retinopathy (PDR) 65

    Clinical Findings 65

    Diagnostic Tools 67

    Treatment Strategies 67

    Diabetic Macular Edema (DME) 69

    Classification 70

    Clinical Findings 71

    Diagnostic Tools 71

    Treatment Strategies 71

    Conclusions 73

    References 74

    6 Diabetic Retinopathy – Research 79
    Gopalan Gnanaguru

    Retina and Induction of Hyperglycemia 79

    Hyperglycemia and Retinal Microvasculature 80

    Hyperglycemia and Reactive Gliosis 80

    Hyperglycemia and Neurodegeneration 81

    Hyperglycemia and Inflammation 81

    References 82

    7 Diabetic Nephropathy – Clinical 85
    Gianpaolo Zerbini

    Epidemiology 85

    Natural History 86

    Stages of DN 86

    Morphologic Changes 87

    Pathophysiology 88

    Clinical Course 89

    Treatment 90

    Primary Prevention 90

    Secondary Prevention 91

    Tertiary Prevention 91

    Perspectives 91

    References 92

    8 Diabetic Nephropathy – Research 97
    Silvia Maestroni and Gianpaolo Zerbini

    Essential Hypertension and DN 97

    Role of Genetics in the Pathogenesis of DN 99

    Polyol Pathway and Non-Enzymatic Glycation 100

    Environment 100

    Perspectives 101

    Sodium–Glucose Cotransporter-2 (SGLT2) and DN 101

    B7-1 and DN 101

    Animal Models 102

    DN in Induced Model of Type 1 Diabetes Mellitus (T1DM) 102

    DN in Spontaneous Model of T1DM 103

    Ins2Akita Mice 103

    Non-Obese Diabetic (NOD) Mice 104

    OVE26 Friend leukemia virus B (FVB) Mice 104

    DN in Spontaneous Models of T2DM 105

    db/db Mice 105

    References 105

    9 Diabetic Neuropathy – Clinical 111
    Christopher H. Gibbons

    Introduction 111

    Classification of Diabetic Neuropathies 111

    Distal Symmetric Polyneuropathy (DSPN) 112

    Diagnosis 113

    Management 113

    Small Fiber Neuropathy 114

    Diagnosis 115

    Management 115

    Autonomic Neuropathy 116

    Diagnosis 117

    Management 117

    Treatment-Induced Neuropathy of Diabetes (TIND) 119

    Diagnosis 119

    Management 120

    Diabetic Radiculoplexopathy 120

    Diagnosis 120

    Management 121

    Mononeuropathies 121

    Diagnosis 121

    Management 121

    Cranial Neuropathies 121

    Diagnosis 121

    Management 122

    Screening for Neuropathy 122

    Summary of Management of Diabetic Neuropathy 122

    References 123

    10 Diabetic Neuropathy – Research 129
    Krish Chandrasekaran, Lindsay A. Zilliox, and James W. Russell

    Basic and Translational Research in Diabetic Neuropathy 129

    Animal Models of Diabetic Neuropathy 129

    Basic Pathophysiology of Diabetic Neuropathy 131

    Changes in Redox Potential 131

    Role of Mitochondrial Dysfunction in Diabetic Neuropathy 133

    Protein Kinase C (PKC) and Neuropathy 137

    Advanced Glycation End Products 137

    Modifying Molecular Chaperones 138

    Inflammation and Neuropathy 138

    TGF-β and Neuropathy 138

    Metabotropic Glutamate Receptors (mGluRs) and Oxidative Injury 139

    Growth Factors and Diabetes 139

    Clinical Research in Diabetic Neuropathy 140

    Treatment of Hypertension 141

    Improved Glycemic Control 141

    Diet and Lifestyle Interventions 142

    Alpha-Lipoic Acid 144

    Benfotiamine and Neuropathy 145

    Treatment of Neuropathic Pain 145

    Acknowledgments 146

    References 147

    11 Diabetic Foot – Clinical 157
    Cristian Nicoletti

    Introduction and Size of the Problem 157

    Pathogenesis of Diabetic Foot Complications 158

    Neuropathy 158

    Peripheral Vascular Disease 158

    Other Risk Factors 159

    Prevention 159

    Treatment 160

    Treatment of Neuropathic Diabetic Foot Ulcers: Offloading 160

    Treatment of PAD: Revascularization 161

    Diabetic Foot Infections (DFIs) 163

    Introduction 163

    Diagnosis 163

    Treatment 164

    Wound Healing 166

    Debridement 166

    Dressings 167

    Topical Negative Pressure Wound Therapy (NPWT) 167

    Other Topical Treatments 167

    References 167

    12 Diabetic Foot – Research 173
    Georgios Theocharidis and Aristidis Veves

    Introduction 173

    Anatomy of the Skin and Microcirculation 174

    Structural Changes in the Microcirculation 174

    Functional Changes in the Microcirculation 175

    Functional Changes in the Diabetic Foot 176

    Vasodilation 176

    Endothelium-Dependent Vasodilation 177

    Endothelium-Independent Vasodilation 178

    Nerve Axon Reflex 179

    Mechanisms of Endothelial Dysfunction 180

    Endothelial Dysfunction and Hyperglycemia 180

    Endothelial Dysfunction and Insulin Resistance 182

    Endothelial Dysfunction and Inflammation 183

    Pathophysiology of Diabetic Wound Healing 184

    Hyperglycemia 184

    Chronic Inflammation 184

    Impaired Angiogenesis and Vasculogenesis 186

    Hypoxia 186

    Impaired Neuropeptide Signaling 186

    Adjunctive Treatment Options 186

    Bioengineered Skin Substitutes 187

    Growth Factors 187

    Hyperbaric Oxygen Therapy 188

    Negative Pressure Wound Therapy 188

    Electrical Stimulation and Shockwave Therapy 189

    Future Therapeutic Perspectives 189

    Gene Therapies 189

    Stem Cell Therapies 189

    Norleu3-Angiotensin-(1–7) 190

    Neuropeptides 190

    Cytokine Inhibition 190

    Conclusion 191

    References 191

    13 Coronary Microvascular Dysfunction in Diabetes – Clinical and Research 201
    Guglielmo Gallone, Francesco Moroni, and Marco Magnoni

    Introduction 201

    Clinical Classification and Mechanisms of CMD 202

    CMD in Diabetic Patients 203

    Clinical Assessment of CMD 205

    Non-Invasive Imaging Technique for the Assessment of CMD 205

    Transthoracic Doppler Evaluation 205

    Contrast Echocardiography 206

    Cardiovascular Magnetic Resonance (CMR) Imaging 206

    Positron Emission Tomography (PET) 207

    Invasive Techniques for the Evaluation of CBF 207

    Indicator Dilution-Based Methods 207

    Thermodilution 208

    Gas Wash Out Method 208

    Intracoronary Doppler Flow Wire 208

    Treatment for CMD 210

    The Effects of Glucose-Lowering Drugs on CMD 211

    Future Perspectives for the Treatment of CMD in Diabetes 211

    References 212

    14 Cerebral Microvascular Disease in Diabetes – Clinical and Research 221
    Eelco van Duinkerken and Richard G. IJzerman

    Introduction 221

    Postmortem Studies of the Brain in Diabetes 222

    Cerebral Small Vessel Disease on MRI 223

    MRI-Measured Cerebral Small Vessel Disease in Type 1 Diabetic Patients 224

    White Matter Hyperintensities 224

    Cerebral Microbleeds 226

    Summary 226

    Type 2 Diabetes and Cerebral Small Vessel Disease 227

    Lacunar Infarcts 227

    White Matter Hyperintensities 228

    Cerebral Microbleeds 230

    Synthesis 230

    Clinical Impact of Cerebral Small Vessel Disease in Diabetes 231

    Cognitive Functioning 231

    Stroke 233

    Dementia 234

    The Influence of Microvascular Disease on the Structure and Functioning of the Diabetic Brain 235

    Type 1 Diabetes 236

    Type 2 Diabetes 237

    Conclusions and Future Directions 239

    References 240

    Index 247



  • Goldman-Cecil Medicine, 2-Volume Set
    La comanda in aproximativ 4 saptamani
    92900lei 800.00 lei



    To be the best doctor you can be, you need the best information. For more than 90 years, what is now called Goldman-Cecil Medicine has been the authoritative source for internal medicine and the care of adult patients. Every chapter is written by acclaimed experts who, with the oversight of our editors, provide definitive, unbiased advice on the diagnosis and treatment of thousands of common and uncommon conditions, always guided by an understanding of the epidemiology and pathobiology, as well as the latest medical literature.

    But Goldman-Cecil Medicine is not just a textbook. Throughout the lifetime of each edition, periodic updates continually include the newest information from a wide range of journals. Furthermore, Goldman-Cecil Medicine is available for all users of ClinicalKey, Elsevier’s full library of subspecialty textbooks that can be accessed by readers who may want even more in-depth information.

    Table Of Contents:

    1. Approach to Medicine, the Patient, and the Medical Profession: Medicine as a Learned and Humane Profession
    2. Bioethics in the Practice of Medicine
    3. Care of Dying Patients and Their Families
    4. Cultural and Social Disparities in Health Care
    5. Global Health
    6. Approach to the Patient: History and Physical Examination
    7. Approach to the Patient with Abnormal Vital S