This is a one-of-a-kind book: combining easy-to-understand science, in-the-trenches political warfare, and inspirational stories. It aims to give hope to individuals and families who suffer from chronic disease or disability; to point out how ordinary people can make an extraordinary difference in the battle to ease suffering and save lives through supporting medical research; to share in “people talk” some of the amazing progress already achieved in the new field of stem cell research; to show how even such a magnificent success as the California stem cell program is under constant attack from ideological groups; to offer medical research as a force for international cooperation; to suggest how cure research lessens the need for the mountainous costs of endless care.Unparalleled background: the author has been involved in virtually every important stem cell battle (state, national, and international) since embryonic stem cell research began. The author works closely with Robert N. Klein, sponsor of the California stem cell program, the largest source of such stem cell research funding in the world. In addition, the author is an award-winning teacher as well as writer, and seeks to entertain as well as educate. His book is not only substantive, but also fun.The book would be a treasured gift: for anyone suffering an “incurable” illness or who is a caregiver for a loved one; for a college student considering a rewarding career in biomedicine; for scientists who want to protect and enhance their research funding; and for anyone who wants to see government respond to the needs of its citizenry. Chronic disease and disability are a prison: cure is the triumphant escape — wheelchairs should be for temporary occupancy only.

50 Studies Every Internist Should Know presents key studies that shape today's practice of internal medicine. Selected using a rigorous methodology, the studies cover topics including: preventative medicine, endocrinology, hematology and oncology, musculoskeletal diseases, nephrology, gastroenterology, infectious diseases, cardiology, pulmonology, geriatrics and palliative care, and mental health. For each study, a concise summary is presented with an emphasis on the results and limitations of the study, and its implications for practice. An illustrative clinical case concludes each review, followed by brief information on other relevant studies. This book is a must-read for health care professionals and anyone who wants to learn more about the data behind clinical practice.

 Now revised for its third edition, the Oxford Handbook of Clinical Diagnosis provides a concise and practical summary of the reasoning processes behind clear and confident diagnosis. The handbook is set out systematically with symptoms and signs through each specialty, and includes a detailed description of the basis of logical evidence-based differential diagnosis. 
This new edition has been updated with clearer diagrams and brand new images. Including rarer diagnoses alongside the common conditions, and vital information about longer-term management alongside the initial treatments, this handbook will ensure your excellence and confidence no matter what signs and symptoms your patient presents with. Providing practical help when dealing with problems outside your area of expertise or with unforeseen situations, you can be sure that this handbook will be your perfect companion to clear and confident diagnoses throughout your medical career.

Fully updated and revised for its second edition, the Oxford Handbook of Clinical Examination and Practical Skills is the only truly comprehensive pocket guide to all aspects of history taking, physical examination, practical procedures, data interpretation, and communication skills. Packed with expert knowledge and practical guidance it gives realistic advice on coping with common situations. The handbook is structured to allow rapid reference of key information, and to aid understanding with concise and practical clinical guidance. Full colour throughout, it includes over 140 detailed photographs and diagrams of all common examination skills to show you exactly what you need to do and the theory, practice and complications for each. More photos have been included, with over half completely new and specially produced for this edition. Each system chapter covers applied anatomy, history, examination, and the presentation of common and important disorders. Data interpretation covers the basics of x-rays, ECGs and other key areas. A new chapter on the eyes is included along with the sections on body language and non-verbal communication, and the section on practical procedures has been expanded. This handbook will help to ensure you have the confidence and skill to carry out an 'A' grade examination every time.

Now in its tenth edition, the Oxford Handbook of Clinical Medicine has been fully revised, with five new authors on the writing team bringing content fresh from the bedside.

Space has been breathed into the design, with more core material at your fingertips in quick-reference lists and flow diagrams, and key references have been honed to the most up-to-date and relevant. Each page has been updated to reflect the latest changes in practice and best management, and the chapters on gastroenterology, history and examination, infectious disease, neurology, and radiology have been extensively revised.

Unique among medical texts, the Oxford Handbook of Clinical Medicine is a complete and concise guide to the core areas of medicine that also encourages thinking about the world from the patient's perspective, offering a holistic, patient-centred approach.

Loved and trusted by millions for over three decades, the Oxford Handbook of Clinical Medicine continues to be a truly indispensable companion for the practice of modern medicine.

Cholestasis is not a disease but rather a symptom of many diseases. It is defined as a pathologic state of reduced bile formation or flow. More specifically, cholestasis is any condition in which substances normally excreted into bile are retained. The serum concentrations of conjugated bilirubin and bile salts are the most commonly measured. In this issue, an international list of expert authors address topics such as the mechanisms of cholestasis and the insights gained from several new studies, the role of mitochondria have in cholestatic reactions to toxic drug effects, the medical treatment of cholestasis, and cholangiocarcinoma.

Specifically designed to prepare medical students for their initial encounters with patients with heart disease, this award-winning text bridges basic cardiac physiology with clinical care. Written by internationally recognized Harvard Medical School faculty and select medical students, Pathophysiology of Heart Disease, Sixth Edition provides a solid foundation of knowledge regarding diseases of the heart and circulation. Under the experienced editorial guidance of Dr. Leonard S. Lilly, this best-selling monograph has an outstanding reputation among medical students and faculty worldwide. Student-friendly features of the Sixth Edition include a new, full-color design and illustrations; end-of-chapter summaries; updated content, including recent technological advances; and access to an interactive eBook. New full-color presentation makes the text more visually appealing. Up-to-date medical imaging and color clinical photographs show real-world examples of cardiovascular diseases and related conditions. Updated Chapter Summaries reflect consistency in length and format, making study easier. Updated Additional Reading references keep readers abreast of the latest literature in the field. Winner of two awards of excellence from the American Medical Writers Association, and recommended by medical schools worldwide. Now with the print edition, enjoy the bundled interactive eBook edition, offering tablet, smartphone or accessed online to: Complete content with enhanced navigation A powerful search tool that pulls results from content in the book, your notes, and even the web Cross-linked pages, references, and more for easy navigation A highlighting tool for easier reference of key content throughout the text Ability to take and share notes with friends and colleagues Quick-reference tabbing to save your favorite content for future use

 Written by clinicians renowned in their respective fields, CMDT offers the most current insight into epidemiology, symptoms, signs, and treatment for more than 1,000 diseases and disorders. For each topic, you’ll find concise, evidence-based answers to questions about hospital and ambulatory medicine. This streamlined clinical companion is the fastest and easiest way to keep abreast of the latest diagnostic advances, prevention strategies, and cost-effective treatments. 

This popular handbook is a practical guide for physicians, surgeons, nurses, and other professionals who manage kidney transplant patients. It is concise, readable, and well-illustrated. Chapters outline the major concerns surrounding renal transplantation and the most successful approaches to problems arising in short-term and long-term patient care. Chapter topics include immunobiology and immunosuppression, as well as chapters on surgery, histocompatibility, and the first three months post-transplant surgery.

 mprove medical and developmental outcomes in high-risk infants with evidence-based management strategies

"Beyond the NICU" is the first book to deliver practical, evidence-based strategies for healthcare providers caring for the NICU graduate during convalescence and after discharge. It is a guide to the successful transition of a high-risk infant from intensive care to the intermediate-level nursery, and then, to help the child thrive outside of the hospital in a home environment.

To advance the standard of care of these vulnerable patients, "Beyond the NICU" draws together clinically focused guidelines to improve patient outcomes and reduce hospital readmissions. Drawing on an international team of respected authorities, "Beyond the NICU" provides the strategies necessary to ensure the success of convalescing NICU graduates in both inpatient and outpatient settings. Doody's Review! Score: 95/100 
Description
This is a nearly 1,000-page softcover book written by over 100 contributors on convalescent neonatal care and post-discharge care of the high-risk infant. The format is similar to other neonatal handbooks (Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 7th edition, Gomella, et al. (McGraw-Hill, 2013); Manual of Neonatal Care, 7th edition, Cloherty et al. (Lippincott Williams & Wilkins, 2011)), but it emphasizes transitional care of the sick infant. 
Purpose
The purpose is to provide "practical, evidence-based strategiesfor the NICU graduate during convalescence and after discharge." The book functions like a practical handbook for clinicians in the NICU, covering almost all aspects of neonatal care, but emphasizing convalescent care. This is an area that has not been well covered in other neonatal books, and this book meets the objectives. 
Audience
The audience is NICU caregivers at all levels and of all disciplines. The book is written in outline format and emphasizes care rather than pathophysiology. The senior editor, his three consultants, and many of the contributors are recognizable names in the field. 
Features
The 51 chapters are grouped into four sections. After an introductory section which includes chapters on the role of the primary care provider for the NICU graduate, the book covers most aspects of care of preterm and term infants in the next two sections. A final section on developmental care includes chapters on early intervention and palliative care. Although the book is supposed to emphasize convalescent and post-discharge care, much of the second and third sections deals with standard early diagnosis and treatment of common neonatal issues, which adds significant length to the book. The book is at its best when it sticks to its title and emphasizes care "beyond the NICU." Helpful appendixes include discharge checklists, home equipment, and even billing coding for the NICU graduate. Illustrations and tables are sparse, but some are unique and very helpful. 
Assessment
This is a unique neonatal book in its emphasis on convalescent and post-discharge care for the sick neonate. It should become a standard text for clinicians in this field and, as it matures in subsequent editions, should abbreviate the acute care sections and concentrate on its title.

Unic printre textele medicale, Manualul Oxford de Medicină Clinică (ediția a zecea) reprezintă un material complet și concis pentru specializările principale ale medicinei și oferă o abordare holistică, centrată pe pacient. Ediția a zecea prezintă informații-cheie actualizate, iar capitolele privind gastroenterologia, bolile infecțioase, neurologia și radiologia au fost complet revizuite. Abordarea tematică se suprapune cu evaluarea clasică a fiecărui caz: anamneză și examenul obiectiv, apoi descrierea patologiei pe aparate și sisteme, cu exemple, scheme, tabele și imagini, care aduc valoare practicii medicale.

Apreciat de medici de peste trei decenii, Manualul Oxford de Medicină Clinică continuă să fie un ghid cu adevărat indispensabil pentru practica medicinei moderne.

Cuprins:

Conținutul fiecărui capitol este detaliat pe pagina dedicată acestuia.

Prefață la ediția în limba română și la ediția a X-a vi

Mulțumiri vii

Simboluri și abrevieri viii

1 Cugetări medicale 0

2 Istoric și examinare 40

3 Patologie cardiovasculară 110

4 Pneumologie 182

5 Endocrinologie 224

6 Gastroenterologie 266

7 Nefrologie 324

8 Hematologie 364

9 Boli infecțioase 424

10 Neurologie 506

11 Oncologie și îngrijiri paliative 580

12 Reumatologie 606

13 Chirurgie 636

14 Biochimie clinică 742

15 Sindroame eponime 774

16 Radiologie 800

17 Intervale de referință și alte aspecte 832

18 Proceduri practice 840

19 Urgențe 860

20 Referințe 936

Scorul de avertizare timpurie 952

Stopul cardiac 954

Essential Cell Biology provides a readily accessible introduction to the central concepts of cell biology, and its lively, clear writing and exceptional illustrations make it the ideal textbook for a first course in both cell and molecular biology. The text and figures are easy-to-follow, accurate, clear, and engaging for the introductory student. Molecular detail has been kept to a minimum in order to provide the reader with a cohesive conceptual framework for the basic science that underlies our current understanding of all of biology, including the biomedical sciences. The Fourth Edition has been thoroughly revised, and covers the latest developments in this fast-moving field, yet retains the academic level and length of the previous edition. The book is accompanied by a rich package of online student and instructor resources, including over 130 narrated movies, an expanded and updated Question Bank, and new enhanced assessments for students.

For over half a century Davidson's Principles and Practice of Medicine has informed and educated students, doctors and other health professionals all over the world, providing a comprehensive account of the practice of medicine. Davidson's Essentials of Medicine provides the core content of the main textbook in a condensed format which will be invaluable whenever you are on the move - whether commuting, travelling between training sites, or on electives. This book provides a distillation of the core information required for clinical studies in medicine. While retaining the acclaimed readability of the main textbook it presents the key information in a format more appropriate for practical clinical work. The contents have been carefully selected by a team of junior doctors, emphasising only the topics that will be essential for clinical studies.

The book includes additional chapters of content to aid clinical practice including a practically-focussed chapter on therapeutics and a useful guide to interpreting major clinical investigations. The text draws directly on the depth and breadth of experience of the Davidson's authors and its International Advisory Board. Updated to include key changes and new illustrations included in Davidson's Principles and Practice of Medicine.

Now reflecting a greater focus on today's multidisciplinary approach to care, Critical Care Handbook of the Massachusetts General Hospital, 6th Edition, remains your go-to guide for practical, complete, and current information on medical and surgical critical care. The user-friendly, outline format is designed for rapid reference, providing reliable, hospital-tested protocols that reflect today's most advanced critical care practices. Key Features*Heavily revised to reflect today's need to include all care providers to optimize treatment*New section on Health Care Services, with chapters on handovers and transitions, long-term outcomes of ICU patients, EICU and electronic systems, quality improvement, and more*New chapters on critical care management of Ebola virus disease, ECMO and ventricular assist devices, and critical care of the obstetrical patient*New videos available online*Complete, concise, full-color coverage of this rapidly enlarging field*Convenient pocket size for on-the-go referenceNow with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like:*Complete content with enhanced navigation*Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web*Cross-linked pages, references, and more for easy navigation*Highlighting tool for easier reference of key content throughout the text* Ability to take and share notes with friends and colleagues*Quick reference tabbing to save your favorite content for future use

The 11th edition of the pre-eminent textbook on physical examination contains foundational content to guide students’ approaches to history taking, interviewing, and other core assessment skills, as well as fully illustrated, step-by-step techniques that outline correct performance of physical examination. The book features a vibrant full-color art program and an easy-to-follow two-column format with step-by-step examination techniques on the left and abnormalities with differential diagnoses on the right. The comprehensive, evidence-based content is intended for medical students, high-level nursing education and practice markets, as well as related health professions such as physician assistants. New for this edition: --Content has been fully revised and updated to reflect the most recent health care literature. --More than 200 new and revised photographs and drawings have been added to better illustrate key points in the accompanying text. --Design and layout has been revised to increase discoverability of core material and special assessment tips. --Techniques of interviewing chapter has been reorganized to provide clearer insights into the skills of empathic listening.

 The ninth edition of this best-selling textbook of clinical medicine builds even further on its formidable, prize-winning formula of excellence, comprehensiveness and accessibility.

‘This book is stunning in its breadth and ease-of-use. It still remains the "gold standard", thorough guide to clinical medicine its forefathers were.’ BMA Medical Book Awards judges.

New to this edition:

 

• 2 new chapters: Global Health and Women’s Health.

 

• 25 new authors.

 

• New online editor, Adam Feather, with a team of young doctors to augment the e-book which accompanies the print book with clinical tips, key learning points, drug tips, learning challenges, case studies and MCQs.

 

• Full text redesign to incorporate:

New system overview diagrams for clinical chapters.

New coloured headings to help identify content relating to disease, management, investigations etc.

New icons to aid text navigation.

11 new members and a new co-editor, Senaka Rajapakse, of the International Advisory Board.

Edited by Kumar and Clark, clinicians and educators of world-renowned expertise.

Authors comprise consultants at the top of their fields, paired with younger doctors closer to the exam experience, to ensure authority and relevance.

Enhanced e-book accompanies the print book, for ease of transportation and use on the move.

International Advisory Board, led by Professor Janaka de Silva and Professor Senaka Rajapakse, providing guidance for global coverage from across the world.

Contributions to the e-book by members of the International Advisory Board to amplify areas of clinical importance in their parts of the world

2 new chapters

 

• Women’s health

 

• Global health

25 new young consultant authors teamed with clinicians at the top of their career, to ensure the text is accessible for students and trainees.

A new role of online Editor. Adam Feather and his team of young doctors, have created (in the e-book) a host of embedded features including: chapter summaries, key-point boxes, self-assessment, top tips, extra content (videos and images) and more… They have focused on enabling more inexperienced learners to interpret the detail, navigate the content effectively and get the most from the text.

New co-editor for the International Advisory Board, Professor Senaka Rajapakse from the University of Colombo.

11 new members of the International Advisory Board.

9 new online international articles, including:

 

• Ebola

 

• Crimean Congo Hemorrhagic Fever

 

• Visceral Leishmaniasis

Full text re-design

 

• New diagrammatic anatomy and physiology overviews at the beginning of clinical systems chapters

 

• Coloured headings to help distinguish sciences, procedures, etc.

 

• New icons to aid text navigation

 

• Divided into three sections for greater ease of navigation:

 

• Good Medical Practice

 

• Clinical Sciences

 

• Clinical Practice

Bigger chapters unbundled into smaller chapters for ease of access.

 

• Clinical Pharmacy now separate from Poisoning

 

• STIs and HIV now separate from Infectious Disease

 

• Biliary Tract and Pancreatic Disease now separate from Liver

 

• Rheumatic Disease now separate from Bone Disease

 

• Lipid and Metabolic Disease now separate from Diabetes Mellitus

 Designed for busy medical practitioners who need a trustworthy, current, and easy-to-use resource, Conn’s Current Therapy 2016focuses solely on up-to-date treatment protocols for the most common complaints, acute diseases, and chronic illnesses. Covering more than 300 topics, Drs. Edward T. Bope and Rick D. Kellerman present the expertise and knowledge of hundreds of skilled international leaders on evidence-based clinical management options, ensuring you're well equipped with the practical and accurate guidance needed for effective patient care.

Ferri's Clinical Advisor 2016 is simply the fastest, most effective way to access up-to-date diagnostic and treatment information on more than 700 common medical conditions. The popular "5 books in 1" format provides quick guidance on diseases and disorders, differential diagnoses, medical algorithms, laboratory tests, and clinical practice guidelines. Yearly updates by experts in key clinical fields ensure that you're current with fast-changing medical knowledge, and extra electronic content delivers more than 100 exclusive topics, additional algorithms, and much more.

Ideal for residency, fellowship, clinical practice, and board review, the National Kidney Foundation's Primer on Kidney Diseases, 7th Edition, by Drs. Scott J. Gilbert and Daniel E. Weiner, offers comprehensive coverage of adult and pediatric kidney diseases in an authoritative, practical resource. Well organized and highly readable, it covers every relevant topic in the field, from anatomy, physiology, and pathophysiology, to diagnosis and management of kidney disease, to fluid and electrolyte disorders, hypertension, dialysis, and renal transplantation. Trusted by nephrologists at all levels of experience for nearly 25 years, this powerful learning tool and clinical reference is a joint publication of Elsevier and the National Kidney Foundation.

Thoroughly covers hot topics in this fast-changing field, including ongoing clinical research and changing treatment protocols. A new chapter on inherited kidney diseases, with a specific focus on APOL1 and the implications of APOL1 carrier status for kidney disease in African-Americans. A new approach to membranoproliferative glomerulonephritis, focusing on the role of complement as a way to approach both the diagnosis and treatment of these diseases. Additions to the chapter on hemodialysis, specifically incorporating information on hemodiafiltration. Updates in the management of hypertension, incorporating results from SPRINT and ACCORD as well as data on treatment of renal artery sclerosis and renal denervation into the approach for blood pressure management. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

This book presents a comprehensive and state-of the-art approach to vascular disease for the geriatric patient, focusing on vascular pathology and interventions but also on perioperative care, anesthetic care, functional outcomes and quality of life, as well as ethical considerations that impact decision making. The book addresses open and endovascular interventions in different vascular beds, as well as preoperative workup and optimization, anesthetic considerations, all aspects and expectations of the postoperative care and recovery and is the only book to include specialize in the intricacies of the care of the geriatric patients, the challenging recovery and neurocognitive changes, and ethical considerations for the end stage geriatric patient or in the setting of postoperative complications. Written by experts in the field, each section addresses patient selection, pre-operative considerations, technical conduct of the most common operations with open or endovascular options, and avoiding complications. A brief review of the existing literature addressing the particular topic follows in each section. With its concise yet comprehensive summary of the field, Vascular Disease in Older Adults is the ultimate resource for geriatricians, cardiologists, surgeons, anesthesiologists, and all physicians of who care for the aging patient with vascular disease.

Designed for busy primary care specialists and other first-line care providers, Conn's Current Therapy 2018, by Drs. Edward T. Bope and Rick D. Kellerman, delivers up-to-date treatment information in a concise yet in-depth format. Recognized leaders in the field provide their personal approaches and evidence-based clinical management options for the conditions you're most likely to see in your everyday practice. Follows a consistent, templated format throughout, with diagnosis, therapy, drug protocols, and treatment pearls presented in easy-to-use boxes and tables for fast reference. Includes nearly 300 images, including algorithms, anatomical illustrations, and photographs, that provide useful information for diagnosis. Focuses on the most current diagnosis and treatment protocols for common complaints, acute diseases, and chronic illnesses - more than 300 topics, all carefully reviewed and updated. Features new and significantly revised chapters on Acute Myocardial Infarction, Hypertension, Peripheral Arterial Disease, Valvular Heart Disease, Hepatitis C, Adrenocortical Insufficiency, Urethral Strictures, Obsessive Compulsive Disorder, Chronic Obstructive Pulmonary Disease, Fibromyalgia, Menopause, Travel Medicine, and much more. Provides current drug information thoroughly reviewed by PharmDs.

The first edition of this book, published in 2009, was the only book of its kind dedicated exclusively to the diagnosis and management of pulmonary arterial hypertension (PAH) in patients with interstitial lung disease (ILD). Over the past few years, new diagnostic tests and treatments of pulmonary arterial hypertension have been developed and tested. Diagnostic testing has led to more frequent and specific diagnosis in PAH patients, leading to the more widespread use of effective treatment and improved quality of life and reduction of mortality for PAH patients. Pulmonary Hypertension and Interstitial Lung Disease: A Clinical Guide, Second Edition provides an updated and expanded state-of-the-art overview of the problems seen by physicians in the clinical management of ILDs. The first section of the book discusses general features and includes an overview of clinical features, diagnosis and pathology of ILD. The second part discusses specific disorders such as idiopathic pulmonary fibrosis, sarcoidosis, and hypersensitivity pneumonia. Pulmonary Hypertension and Interstitial Lung Disease, Second Edition is an invaluable resource for all physicians whose practice involves the care and treatment of patients with interstitial lung disease. The first edition of this book, published in 2009, was the only book of its kind dedicated exclusively to the diagnosis and management of pulmonary arterial hypertension (PAH) in patients with interstitial lung disease (ILD). Over the past few years, new diagnostic tests and treatments of pulmonary arterial hypertension have been developed and tested. Diagnostic testing has led to more frequent and specific diagnosis in PAH patients, leading to the more widespread use of effective treatment and improved quality of life and reduction of mortality for PAH patients. Pulmonary Hypertension and Interstitial Lung Disease: A Clinical Guide, Second Edition provides an updated and expanded state-of-the-art overview of the problems seen by physicians in the clinical management of ILDs. The first section of the book discusses general features and includes an overview of clinical features, diagnosis and pathology of ILD. The second part discusses specific disorders such as idiopathic pulmonary fibrosis, sarcoidosis, and hypersensitivity pneumonia. Pulmonary Hypertension and Interstitial Lung Disease, Second Edition is an invaluable resource for all physicians whose practice involves the care and treatment of patients with interstitial lung disease.

This textbook provides a comprehensive, state-of-the art review of the field of hernia surgery, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in both inguinal and ventral/incisional hernia. This book provides an overview of the current understanding of the biologic basis of hernia formation as well as laying the foundation for the importance of hernia research and evaluating outcomes in hernia repair. Diagnosis and management strategies for inguinal and ventral hernia are discussed in detail with separate techniques sections for the most widely used procedures in this field as well as emerging technologies such a robotic and single incision surgery.

Pertinent associated topics to inguinal hernia surgery such as chronic groin and athletic pubalgia are covered in detail. For incisional hernias, associated topics such as hernia prevention and enhanced recovery protocols are discussed. For both inguinal and ventral/incisional hernias mesh choices and available mesh technologies are discussed in detail as this remains an often confusing matter for the general surgery. When appropriate, chapters to highlight controversies in care are featured such as the use of synthetic mesh in contaminated surgery and laparoscopic closure of defects in laparoscopic ventral hernia repair.

Rheumatoid Arthritis and Proteus explores the idea that Rheumatoid arthritis is caused by a urinary tract infection as a result of Proteus bacteria. Rheumatoid arthritis is a severe, painful and crippling disease affecting millions of people throughout the world, especially women. Genetic studies over the last 30 years have shown that individuals who possess the white cell blood groups HLA-DR1/4 carry a susceptibility sequence and are more likely to develop the disease. This book uses the methods of Sir Karl Popper, the philosopher of science, to present 12 “Popper sequences” which have been identified to indicate that Proteus is the causative agent of Rheumatoid Arthritis. Rheumatoid Arthritis and Proteus proposes that Anti-Proteus therapies should be followed as early as possible to prevent the crippling and irreversible joint deformities that occur in Rheumatoid Arthritis.

 Respiratory problems are the most common cause of acute admission to hospital. A variety of diagnostic investigations are required, both for acute and clinic assessment. Making Sense of Lung Function Tests, Second Edition familiarises both trainees and more experienced clinicians with the interpretation of a range of respiratory parameters. It places lung function in a clinical context using real-life examples and provides invaluable hands-on guidance.

For this second edition Consultant Respiratory Physician Jonathan Dakin and Consultant Anaesthetist Elena Kourteli are joined by Mark Mottershaw, Chief Respiratory Physiologist from Queen Alexandra Hospital, Portsmouth, all contributing a broad range of expertise and perspectives. Together they have updated the book throughout and added new chapters including an algorithm for interpretation of pulmonary function tests, exhaled nitric oxide (FE_NO) and cardiopulmonary exercise testing.

The text offers a clear explanation of the concepts which students find difficult, including:

 

• The basis of obstructive and restrictive defects

 

 

• Pattern recognition of the flow volume loop

 

 

• Differences between TL_CO and K_CO

 

 

• Assessment of oxygenation using PO₂ and SO₂

 

 

• The basis of Type 1 and type 2 respiratory failure

 

 

• Distinguishing respiratory and metabolic acidosis

 

 

• The relationship between sleep and respiratory failure

 

The information is presented in an accessible way, suitable for those seeking a basic grounding in spirometry or blood gases, but also sufficiently comprehensive for readers completing specialist training in general or respiratory medicine.

Since 1927, Goldman-Cecil Medicine has been the world’s most influential internal medicine resource. In the ground-breaking 25th edition, your original purchase ensures you will be up-to-date without the need for a subscription. Through the new, more powerful Expert Consult eBook platform, this "living text" provides continuous updates that will integrate the latest research, guidelines, and treatments into each chapter, ensuring that the content is as current as the day this edition was first published. Goldman-Cecil Medicine offers definitive, unbiased guidance on the evaluation and management of every medical condition, presented by a veritable "Who's Who" of modern medicine. A practical, straightforward style; templated organization; evidence-based references; and robust interactive content combine to make this dynamic resource quite simply the fastest and best place to find all of the authoritative, state-of-the-art clinical answers you need.
Features:
• Expert Consult eBook version included with print purchase:
• Access continuous updates from Editor Lee Goldman, MD, who thoroughly reviews internal medicine and specialty journals, updating online content to reflect the latest guidelines and translating that evidence into treatment.
• Interactive Q&A section features over 1,500 board-style questions and answers to aid in preparing for certification or recertification exams.
• Outstanding supplementary tools include figures, tables, videos, heart and lung sounds, treatment and management algorithms, fully integrated references, and thousands of illustrations and full-color photos.
• Search all of the text, figures, supplementary material, and references from the book on a variety of devices and at no additional cost - Expert Consult access is included with this title!
• Practical, bulleted, highly templated text with easy-to-use features including flow charts and treatment boxes.
• New chapters on global health, cancer biology and genetics, and the human microbiome in health and disease keep you on the cutting edge of medicine.
• Today's most current evidence-based medicine guidelines help you form a definitive diagnosis and create the best treatment plans possible.
• Focused coverage of the latest developments in biology includes the specifics of current diagnosis, therapy, and medication doses.
• The reference of choice for every stage of your career! Goldman-Cecil Medicine is an ideal learning tool for residents, physicians, and students as well as a valuable go-to resource for experienced healthcare professionals.

Clinical Otology is the complete reference for basic scientific information on the functioning of the ear and current techniques for the diagnosis, management, and rehabilitation of patients with common otologic disorders. In this edition the authors address important topics such as the genetic diagnosis of hereditary hearing loss, management of superior canal dehiscence, evidence-based management of otitis media with effusion, middle ear and brain stem implantable hearing devices, new applications of transtympanic therapy, and more. The book features the exquisite color photographs of world-class otologic photographer Eiji Yanagisawa, MD. Highlights of the third edition: New chapters on Molecular Biology and Clinical Otology, Molecular Disorders and Clinical Otology, Pharmacology of Otologic Drugs, and Cystic Lesions of the Petrous Apex More than 400 illustrations and full-color photographs to aid the comprehension of key concepts Comprehensive lists of references for pursuing topics in greater depth All otologists, otolaryngologists, audiologists, neurologists, neurosurgeons, and students seeking to optimize patient care should add this state-of-the-art reference to their professional library.

Thorough and concise, this practical reference provides a unique, on-field management approach to all athletic injuries to the shoulder and elbow, as well as nonoperative and operative treatment options, including arthroscopy and open surgery. Focusing on high-performance athletes, leading authorities in the field demonstrate how to provide pain relief, restore function, and return the athlete to sport and to prior level of performance in a safe and timely fashion. Showcases the knowledge and expertise of an international group of editors and authors who have served as president of the American Orthopaedic Society for Sports Medicine, the American Shoulder and Elbow Surgeons and the Arthroscopy Association of North America, are physicians or consultants for professional and collegiate sports teams, have won awards for research in the field of shoulder surgery, are editors and reviewers for peer-reviewed journals, and much more. Features video clips that clearly depict how to complete an on-field physical exam and various surgical procedures, and contains rehabilitation guidelines and critical return-to-sport protocols - essential information for nonsurgical healthcare providers Contains a section in each chapter covering "On-the-Field Management and Early Post-Injury Assessment and Treatment" - a must-read for immediate care of the injured athlete and ensuring the safe return to play. Covers the most recent advances in the management of tendon tears in elite and overhead athletes, including prevention in youth sports, early sports specialization, and changing standards of care regarding shoulder and elbow instability. Provides a thorough review of current ulnar collateral ligament injury diagnosis, imaging, non-operative management, and surgery, as well as acromioclavicular and sternoclavicular joint injuries, clavicle and olecranon fractures, and OCD of the capitellum. Focuses primarily on athletes under the age of 40, with some consideration of the older athlete (professional golf, for example). Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.

Through six decades, no resource has matched the authority, esteemed scholarship, and scientific rigor of Harrison’s Principles of Internal Medicine. Capturing the countless advances and developments across the full span of medicine, the new 19th edition of Harrison’s provides a complete update of essential content related to disease pathogenesis, clinical trials, current diagnostic methods and imaging approaches, evidence-based practice guidelines, and established and newly approved treatment methods. Here are just a few of the outstanding features of the new Nineteenth Edition: 

Presented in two volumes:

Volume 1 is devoted to foundational principles, cardinal manifestations of disease and approach to differential diagnosis;
Volume 2 covers disease pathogenesis and treatment NEW chapters on important topics such as Men’s Health, The Impact of Global Warming on Infectious Diseases, Fatigue, and many more Critical updates in management and therapeutics in Hepatitis, Coronary Artery Disease, Ebola Virus Disease, Multiple Sclerosis, Diabetes, Hypertension, Deep Vein Thrombosis and Pulmonary Embolism, Acute and Chronic Kidney Disease, Inflammatory Bowel Disease, Lipoprotein Disorders, HIV and AIDS, and more. Increased number of the popular Harrison’s clinical algorithms; clinically relevant radiographic examples spanning hundreds of diseases; clinical-pathological images in full color; crystal clear, full color drawings and illustrations and helpful tables and summary lists that make clinical application of the content faster than ever Access to outstanding multi-media resources including practical videos demonstrating essential bedside procedures, physical examination techniques, endoscopic findings, cardiovascular findings, and more.

 MASTER MODERN MEDICINE!

Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine

The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms.

Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible.

Essential for practice and education, the landmark 20th Edition features:

•                     Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care.

•                     State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals.

•                     All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine— Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine.

•                     Important and timely new chapters—such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more—offer the very latest, definitive perspectives on must-know topics in medical education and practice. 

•                     Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes.

•                     End-of-chapter suggested readings reinforcement

This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field.

Written by experts in their field, Crohn’s Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis, and related autoimmune disorders.

Anesthesiologists, residents, and advanced practice practitioners alike rely upon the comprehensive content of Hagberg and Benumof's Airway Management to remain proficient in this essential area. The 4th Edition, by Drs. Carin A. Hagberg, Carlos A. Artime, and Michael F. Aziz, continues the tradition of excellence with coverage of new devices and algorithms, new research, new outcomes reporting, and much more - while retaining a concise, how-to approach; carefully chosen illustrations; and case examples and analysis throughout. Offers expert, full-color guidance on pre- and post-intubation techniques and protocols, from equipment selection through management of complications. Includes access to more than 25 videos online, including ultrasonography and non-invasive airway management and flexible scope intubation. Includes the latest ASA guidelines, as well as six all-new chapters including airway management in nonoperating room locations (NORA), airway management and outcomes reporting, and more. Features completely rewritten chapters on airway pharmacology, algorithms for management of the difficult airway, airway assessment, video-assisted laryngoscopy, and many more. Reviews new airway devices and techniques, along with indications for and confirmation of tracheal intubation. Brings you up to date with the latest devices, the DAS extubation algorithm, the Vortex approach, and emergency cricothyrotomy. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

 Resulting from ingestion of inappropriately prepared or stored foods containing pathogenic viruses, bacteria, fungi and parasites, foodborne infections have become a significant source of human morbidity and mortality worldwide in recent decades. This may be largely attributable to the remarkable popularity of convenient, ready-to-eat food products, the dramatic expansion of international food trades, and the continuing growth of immuno-suppressed population groups. Although anti-microbial treatments have played a crucial part in the control of foodborne infections in the past, the emergence and spread of anti-microbial resistance render the existing treatments ineffective. Additionally, our limited understanding of the molecular mechanisms of foodborne infections has thwarted our efforts in the development of efficacious vaccines for foodborne pathogens. 

Given the obvious benefits of laboratory models in foodborne disease research, a great number of experiments have been conducted toward the elucidation of host-pathogen interactions in and pathogenic mechanisms of foodborne infections. Forming part of the Food Microbiology series, Laboratory Models for Foodborne Infections presents a state-of-the-art review of laboratory models that have proven valuable in deciphering the life cycle, epidemiology, immunobiology, and other key aspects of foodborne pathogens. 

Written by scientists with respective expertise in foodborne pathogen research, each chapter includes a contemporary summary of a particular foodborne viral, bacterial, fungal, or parasitic infection in relation to its life cycle, epidemiology, clinical features, pathogenesis, host-pathogen interactions, and other related aspects. Besides providing a trustworthy source of information for undergraduates and postgraduates in food microbiology, Laboratory Models for Foodborne Infections offers an invaluable guide for scientists and food microbiologists with interest in exploiting laboratory models for detailed study of foodborne infections.

This book is a fully updated and revised second edition of a highly successful text in which a new concept of knowledge mining, based on explication and transfer of interventional knowledge of experts, has been implemented. The dedicated training program that is set out will serve the needs of all interventional operators, whether cardiologists, vascular surgeons, vascular specialists, or radiologists, enabling them to achieve a consistent expert level across the entire broad spectrum of catheter-based interventions. Operator skills – and in particular decision-making and strategic skills – are the most critical factors for the outcome of catheter-based cardiovascular interventions. Currently, such skills are commonly developed by the empirical trial and error method only. The explicit teaching, training, and learning approach adopted in this book permits the rapid transfer of interventional knowledge and enables individual operators to negotiate steep learning curves and acquire complex skills in a highly efficient manner. It will thereby offer invaluable assistance in meeting successfully the challenges of modern cardiovascular care.

Comprehensive coverage, multidisciplinary guidance, and step-by-step instruction both in print and on video help you choose the best approach and get the best results for any facial rejuvenation challenge. Master Techniques in Facial Rejuvenation, 2nd Edition, by Drs. Babak Azizzadeh, Mark Murphy, Calvin Johnson, Guy Massry, and Rebecca Fitzgerald, presents multiple facial rejuvenation techniques by experts in the fields of plastic surgery, facial plastic surgery, otolaryngology, oculoplastic surgery and dermatology. Competing and complementary techniques focus on all areas of the face, providing a balanced and systematic approach to this fast-growing field. Presents step-by-step, full-color depictions of the authors' surgical techniques, with emphasis on minimally invasive surgery, recent trends, and adjunctive procedures. Addresses facial shape and proportions with injectable agents in youth and age. Provides multiple viewpoints on advanced and time-tested techniques. Features video instruction on ptosis repair blepharoplasty, mentoplasty, non-surgical brow and eyelid rejuvenation, and more. Features expanded coverage of non-invasive procedures such as Botulinum toxin and fillers, neromodulatiors, tightening devices, and panfacial nonsurgical rejuvenation, plus newly updated information on face lifts. Includes all-new chapters on non-surgical brow and eyelid rejuvenation, ptosis repair and blepharoplasty, deep plane rhytidectomy modifications, and orthognathic aesthetic facial surgery. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.

Known for its superb, step-by-step photo sequences, Colour Atlas of Ophthalmic Plastic Surgery, 4th Edition, by Drs. A. G. Tyers and J. R. O. Collin, remains your first choice for gaining essential knowledge in oculoplastic surgery. Ideal for both novices and experienced surgeons, this award-winning title offers comprehensive coverage of ophthalmic plastic surgery including eyelids, brows, and mid-face - all highlighted by unsurpassed photographic sequences and explanatory text that depict key stages of each procedure. New photos and new operative series, as well as major updates throughout the book, make this an invaluable resource for your practice. Provides more than 1,000 high-quality photos of every key step of every procedure, with corresponding explanatory legends and detailed descriptive text, making the surgeries easy to understand and follow. Features discussion of indications, preferences and advice on the management of complications with each chapter. Presents the knowledge and expertise of two internationally acclaimed oculoplastic surgeons, both previous Presidents of the British Oculo-Plastic Surgery Society and the European Society of Ophthalmic Plastic and Reconstructive Surgery. Includes an expanded video collection, now with 25 narrated surgical clips with over 2 hours running time, including brand new recordings and improvements to existing video footage. Includes updated coverage of ptosis surgery, lid and periocular reconstruction, and blepharoplasty and forehead rejuvenation. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Improvements in the detection of fetal and neonatal brain injuries, advances in our understanding of the pathophysiology, cellular and molecular bases of encephalopathy, and new treatment options have all combined to produce significant changes in the management of neonatal brain disorders in the past few years. This new edition of Fetal and Neonatal Brain Injury brings the reader fully up to date with all advances in clinical management and outcome assessment. Updated material includes inflammation focusing in particular on chorioamnionitis and fetal brain injury; genetic brain injury; and expanded sections on cholestasis, diabetes, and thyroid disease. An updated, highly illustrated chapter on structural and functional imaging of the fetal and neonatal brain is also included. An outstanding international team of highly experienced neonatologists and maternal-fetal medicine clinicians have produced a practical, authoritative clinical text that gives clear management advice to all clinicians involved in the treatment of these patients.

Since its revolutionary first edition in 1983, Rosen's Emergency Medicine set the standard for reliable, accessible, and comprehensive information to guide the clinical practice of emergency medicine. Generations of emergency medicine residents and practitioners have relied on Rosen’s as the source for current information across the spectrum of emergency medicine practice.. The 9th Edition continues this tradition of excellence, offering the unparalleled clarity and authority you’ve come to expect from the award-winning leader in the field. Throughout the text, content is now more concise, clinically relevant, and accessible than ever before - meeting the needs of today’s increasingly busy emergency medicine practitioner.

• Outstanding, easy-to-use learning tool with many practical teaching points  
• Excellent clinical, radiological, surgical, and pathological correlation  
• Some 600 color images of intraoperative appearances, gross specimens, and histology, plus 900 radiological images
• Concise discussion of embryology, anatomy, histology, and physiology of the pancreas   Challenging, multiple choice self-assessments ​  

About this book

This innovative teaching atlas provides the reader with a practical approach to the diagnosis and management of the common and uncommon diseases that may involve the pancreatic gland. Its perspective is multidisciplinary, the authors being radiologists, surgeons, pathologists, and gastroenterologists who have worked together for the past 25 years. Very concise descriptions of clinical presentation, pathology, imaging, and management are provided for a great variety of pathologic conditions, and a wealth of illustrative material displays intraoperative appearances, gross specimens, histology, and radiological findings.

Pancreatic surgery, including transplantation, is also discussed, and the final chapter presents a gallery of challenging and diverse cases. Specialists and residents in a range of specialties will find this atlas to be an invaluable aid, and it will also serve as an excellent reference for medical students.

Table of contents (21 chapters)

·         Embryology of the Pancreas and Normal Variants

Casillas, Javier (et al.)

Pages 3-47

·         Anatomy of the Pancreas

Casillas, Javier (et al.)

Pages 49-72

·         Histology of the Pancreas

Ruiz-Cordero, Roberto (et al.)

Pages 73-78

·         Physiology of the Pancreas

Quiroz, Alexander (et al.)

Pages 79-89

·         Imaging of the Pancreas

Casillas, Javier (et al.)

Pages 91-131

·         Serous Cystadenoma (SCA)

Casillas, Javier (et al.)

Pages 135-199

·         Mucinous Cystic Neoplasm of the Pancreas (MCN)

Casillas, Javier (et al.)

Pages 201-240

·         Intraductal Papillary Mucinous Neoplasm (IPMN)

Casillas, Javier (et al.)

Pages 241-327

·         Solid Pseudopapillary Tumor of the Pancreas

Casillas, Javier (et al.)

Pages 329-362

·         Pancreatic Neuroendocrine Neoplasms (PNENs)

Casillas, Javier (et al.)

Pages 365-479

·         Pancreatic Ductal Adenocarcinoma (PDAC)

Levi, Joe U. (et al.)

Pages 481-552

·         Pancreatic Metastases

Casillas, Javier (et al.)

Pages 553-578

·         Unusual Pancreatic Masses (UPA)

Casillas, Javier (et al.)

Pages 579-678

·         Acute Pancreatitis (AP)

Casillas, Javier (et al.)

Pages 681-749

·         Chronic Pancreatitis (CP)

Casillas, Javier (et al.)

Pages 751-794

·         Pancreatic Pseudocyst

Casillas, Javier (et al.)

Pages 795-862

·         Autoimmune Pancreatitis (AIP)

Casillas, Javier (et al.)

Pages 863-897

·         Pancreatic Trauma

Casillas, Javier (et al.)

Pages 901-920

·         Surgical Procedures of the Pancreas

Levi, Joe U. (et al.)

Pages 923-972

·         Pancreas Transplantation

Burke, George W. (et al.)

Pages 973-999

·         Final Assessment

Casillas, Javier (et al.)

Pages 1003-1045

This brand new updated edition of the most comprehensive reference book on pancreatic disease details the very latest knowledge on genetics and molecular biological background in terms of anatomy, physiology, pathology, and pathophysiology for all known disorders. Included for the first time, are two brand new sections on the key areas of Autoimmune Pancreatitis and Benign Cystic Neoplasms. In addition, this edition is filled with over 500 high-quality illustrations, line drawings, and radiographs that provide a step-by-step approach to all endoscopic techniques and surgical procedures. Each of these images can be downloaded via an online image bank for use in scientific presentations. Every existing chapter in The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition has been thoroughly revised and updated to include the many changes in clinical practice since publication of the current edition. The book includes new guidelines for non-surgical and surgical treatment; new molecular biologic pathways to support clinical decision making in targeted treatment of pancreatic cancer; new minimally invasive surgical approaches for pancreatic diseases; and the latest knowledge of neuroendocrine tumors and periampullary tumors. The most encyclopedic book on the pancreas--providing outstanding and clear guidance for the practicing clinician Covers every known pancreatic disorder in detail including its anatomy, physiology, pathology, pathophysiology, diagnosis, and management Completely updated with brand new chapters Over 500 downloadable illustrations An editor and author team of high international repute who present global best-practice The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition is an important book for gastroenterologists and gastrointestinal surgeons worldwide.