pe pagina
  • 165.00 lei

    As per the directives from Ministry of Health and Family Welfare, Government of India, the National Board of Examinations (NBE) would be conducting a computer-based multiple choice questions (MCQs) examination. Candidates appearing for DM (Endocrinology) Entrance Examinations would be expected to answer 40% questions from the feeder specialty and 60% questions would be in Endocrinology. This book is aimed to give students an idea of the kind of questions that they might expect/anticipate in the examinations. Based on the pattern of NEET DM Endocrinology entrance examination. Presented in an easy to read layout. Divided into 25 chapters as per the pattern. Concise answers and explanations. References from standard textbooks. Useful diagrams and tables are incorporated.

  • 19000lei 170.00 lei

    Now in its tenth edition, the Oxford Handbook of Clinical Medicine has been fully revised, with five new authors on the writing team bringing content fresh from the bedside.

    Space has been breathed into the design, with more core material at your fingertips in quick-reference lists and flow diagrams, and key references have been honed to the most up-to-date and relevant. Each page has been updated to reflect the latest changes in practice and best management, and the chapters on gastroenterology, history and examination, infectious disease, neurology, and radiology have been extensively revised.

    Unique among medical texts, the Oxford Handbook of Clinical Medicine is a complete and concise guide to the core areas of medicine that also encourages thinking about the world from the patient's perspective, offering a holistic, patient-centred approach.

    Loved and trusted by millions for over three decades, the Oxford Handbook of Clinical Medicine continues to be a truly indispensable companion for the practice of modern medicine.

  • 180.00 lei

    A full-color case-based review of the essentials of pathophysiology covering all major organs and systems

    The goal of this trusted text is to introduce you to clinical medicine by reviewing the pathophysiologic basis of 132 diseases (and associated signs and symptoms) commonly encountered in medical practice. The authors, all experts in their respective fields, have provided a concise review of relevant normal structure and function of each body system, followed by a description of the pathophysiologic mechanisms that underlie several common diseases related to that system. The accessible presentation features high-quality full-color illustrations, and numerous tables and diagrams.

    Each chapter of Pathophysiology of Disease concludes with a collection of case studies and questions designed to test your understanding of the pathophysiology of each clinical entity discussed. These case studies allow you to apply your knowledge to specific clinical situations. Detailed answers to each case study question are provided at the end of the book. 

    This unique interweaving of physiological and pathological concepts will put you on the path toward thinking about signs and symptoms in terms of their pathophysiologic basis, giving you an understanding of the "why" behind illness and treatment.


    •Twelve additional case studies, bringing the total to 132, one for each of the clinical entities discussed in the book’s 24 chapters
    •More than 2/3 of the chapters are enhanced and refreshed by the input of new contributors
    •Totally revised chapter on neoplasia
    •New chapter sections on urticaria, spinocerebellar ataxia, idiopathic pulmonary fibrosis, and spondyloarthropathies
    •New tables summarizing adverse prognostic signs in acute pancreatitis, genetic syndromes associated with pancreatic cancer, and causes of end-stage renal disease
    •New diagnosis and etiologic classification of diabetes mellitus, and review of mechanisms of newest pharmacologic agents for its treatment
    •Updates on fine-needle aspiration biopsy of thyroid nodules, and thyroid disorders in pregnancy
    •Updated references throughout the book


    Table of Contents:

    Chapter 1: Introduction

    Chapter 2: Genetic Disease

    Chapter 3: Disorders of the Immune System

    Chapter 4: Infectious Diseases

    Chapter 5: Neoplasia

    Chapter 6: Blood Disorders

    Chapter 7: Nervous System Disorders

    Chapter 8: Diseases of the Skin

    Chapter 9: Pulmonary Disease

    Chapter 10: Cardiovascular Disorders: Heart Disease

    Chapter 11: Cardiovascular Disorders: Vascular Disease

    Chapter 12: Disorders of the Adrenal Medulla

    Chapter 13: Gastrointestinal Disease

    Chapter 14: Liver Disease

    Chapter 15: Disorders of the Exocrine Pancreas

    Chapter 16: Renal Disease

    Chapter 17: Disorders of the Parathyroids & Calcium and Phosphorus Metabolism

    Chapter 18: Disorders of the Endocrine Pancreas

    Chapter 19: Disorders of the Hypothalamus & Pituitary Gland

    Chapter 20: Thyroid Disease

    Chapter 21: Disorders of the Adrenal Cortex

    Chapter 22: Disorders of the Female Reproductive Tract

    Chapter 23: Disorders of the Male Reproductive Tract

    Chapter 24: Inflammatory Rheumatic Diseases


  • 185.00 lei

    Tuberculosis (TB) is a bacterial infection spread through inhaling tiny droplets from the coughs or sneezes of an infected person. It mainly affects the lungs, but it can affect any part of the body, including the abdomen, glands, bones and nervous system (NHS Choices). Part of the Clinical Focus series, this book is a comprehensive guide to the diagnosis and treatment of this serious condition. Beginning with an introduction to the microbiology and epidemiology of the disease, the following chapters provide in depth coverage of the clinical assessment, diagnostic techniques, and management options for different strains of tuberculosis. Each chapter is highly illustrated with tables and images to enhance the detailed text. Edited by recognised specialists from Belgrade, Serbia, the new volume in this series includes contributions from highly experienced clinicians throughout the world. Key Points Comprehensive guide to diagnosis and treatment of tuberculosis Part of the Clinical Focus series Highly illustrated with tables and images Internationally recognised editor and author team

  • 19000lei 185.00 lei

    Fully updated and revised for its second edition, the Oxford Handbook of Clinical Examination and Practical Skills is the only truly comprehensive pocket guide to all aspects of history taking, physical examination, practical procedures, data interpretation, and communication skills. Packed with expert knowledge and practical guidance it gives realistic advice on coping with common situations. The handbook is structured to allow rapid reference of key information, and to aid understanding with concise and practical clinical guidance. Full colour throughout, it includes over 140 detailed photographs and diagrams of all common examination skills to show you exactly what you need to do and the theory, practice and complications for each. More photos have been included, with over half completely new and specially produced for this edition. Each system chapter covers applied anatomy, history, examination, and the presentation of common and important disorders. Data interpretation covers the basics of x-rays, ECGs and other key areas. A new chapter on the eyes is included along with the sections on body language and non-verbal communication, and the section on practical procedures has been expanded. This handbook will help to ensure you have the confidence and skill to carry out an 'A' grade examination every time.

  • 19000lei 185.00 lei

     Now revised for its third edition, the Oxford Handbook of Clinical Diagnosis provides a concise and practical summary of the reasoning processes behind clear and confident diagnosis. The handbook is set out systematically with symptoms and signs through each specialty, and includes a detailed description of the basis of logical evidence-based differential diagnosis. 
    This new edition has been updated with clearer diagrams and brand new images. Including rarer diagnoses alongside the common conditions, and vital information about longer-term management alongside the initial treatments, this handbook will ensure your excellence and confidence no matter what signs and symptoms your patient presents with. Providing practical help when dealing with problems outside your area of expertise or with unforeseen situations, you can be sure that this handbook will be your perfect companion to clear and confident diagnoses throughout your medical career.

  • Internal Medicine
    La comanda in aproximativ 4 saptamani
    185.00 lei

    Internal or general medicine is the medical specialty dealing with the prevention, diagnosis and treatment of adult diseases. This second edition provides clinicians and trainees with a complete guide to internal medicine. Divided into 28 sections, the first part of the book is dedicated to the diagnosis and management of cardiac conditions. The second part covers respiratory and pulmonary disorders, gastrointestinal diseases, neurologic disorders, renal conditions and endocrine disorders. The book has been fully revised with new topics added to provide the latest advances in the field. Each chapter examines the pathophysiology and techniques for accurate diagnosis and appropriate therapy. Authored by a recognised, Ottawa-based expert in the field, the new edition features clinical photographs, illustrations and tables to enhance learning. Key points Comprehensive guide to the latest advances in internal medicine Fully revised, second edition covering numerous disorders in different systems of the body Authored by recognised Ottawa-based expert in the field Previous edition (9780812116021) published in 1994

  • Leg Ulcers
    La comanda in aproximativ 4 saptamani
    22500lei 200.00 lei

  • Doctor's Pocket Companion
    La comanda in aproximativ 4 saptamani
    215.00 lei

    A comprehensive book for all kinds of modern medicine doctors, especially for those who work as generalists (General Medicine, Family Medicine) and those who use clinical skill optimally in medical practice. Aims to enrich basic skills of diagnosis and management. Based on problem-oriented approach. Topics are presented systematically for quick reference. Makes the clinical diagnosis easy with less of investigation. Focuses on wider spectrum of readers. Companion reference book for Interns, General Practitioners, Family Doctors, General Physicians and healthcare providers with a holistic attitude toward patient care.

  • 220.00 lei


    Coordonatorii editiei in limba romana: Prof. Dr. Corin Badiu si Prof. Dr. Cristian Baicus

    Unic printre textele medicale, Manualul Oxford de Medicina Clinica (ediția a zecea) reprezinta un material complet si concis pentru specializarile principale ale medicinei si ofera o abordare holistica, centrata pe pacient. Editia a zecea prezinta informatii-cheie actualizate, iar capitolele privind gastroenterologia, bolile infectioase, neurologia si radiologia au fost complet revizuite. Abordarea tematica se suprapune cu evaluarea clasica a fiecarui caz: anamneza si examenul obiectiv, apoi descrierea patologiei pe aparate si sisteme, cu exemple, scheme, tabele si imagini, care aduc valoare practicii medicale.

    Apreciat de medici de peste trei decenii, Manualul Oxford de Medicina Clinica continua sa fie un ghid cu adevarat indispensabil pentru practica medicinei moderne.

     Prefata la editia in limba romana

    „Pornind de la prima pagina, medicul cu experienta sau in formare descopera un nou prieten: o carte sintetizată, bine organizată tematic, atractiva, care expune intr-o combinatie unica elementele de detaliu privind diagnosticul si tratamentul. Sistematizata in 19 capitole, manualul porneste de la un scurt istoric filozofic al domeniului, luand in discutie repere majore ale filozofiei medicale, dar si aspecte etice importante. Principiile medicinei bazate pe dovezi si ale statisticii medicale fac parte din acelasi capitol initial.

    Abordarea tematica se suprapune cu evaluarea clasica a fiecarui caz: anamneză si examenul obiectiv, apoi descrierea patologiei pe aparate si sisteme, cu exemple, scheme, tabele si imagini, care aduc valoare practicii medicale.

    Temele speciale sunt evidentiate prin casete specifice, la care se face trimitere ori de cate ori este necesar. Realizate excelent din punct de vedere grafic, imaginile sunt foarte sugestive, intregind armonios informatia din text si tabele. Manualul include informatii de ultima ora, foarte bine structurate in tabele si algoritmi, care ofera practicianului un sprijin permanent in decizia medicala. Din loc in loc se regasesc istorioare din viata curenta a practicianului sau repere istorice ale domeniului, care fac lectura captivanta.

    Traducerea carții Oxford Handbook of Clinical Medicine a beneficiat de implicarea unui grup de specialisti entuziasti, care au adaptat informatiile la terminologia clasica romaneasca, realizand un text fluent, atractiv si precis. Multumim tuturor celor care au dedicat timp si energie pentru a face posibila aparitia acestui manual in limba romana.

    Sunt convins ca acest volum reprezinta un instrument util atat pentru medicul cu experiența, cat si pentru cel aflat la inceputul carierei, fiecare gasind deopotrivă un prieten de nadejde în Manualul Oxford de Medicina Clinica.

    Va dorim lectura placuta!

    Prof. Dr. Corin Badiu”


    Conținutul fiecarui capitol este detaliat pe pagina dedicata acestuia.

    Prefata la editia in limba romană si la editia a X-a vi

    Mulțumiri vii

    Simboluri si abrevieri viii

    Cugetari medicale 0

    Istoric si examinare 40

    Patologie cardiovasculara 110

    Pneumologie 182

    Endocrinologie 224

    Gastroenterologie 266

    Nefrologie 324

    Hematologie 364

    Boli infectioase 424

    10 Neurologie 506

    11 Oncologie si ingrijiri paliative 580

    12 Reumatologie 606

    13 Chirurgie 636

    14 Biochimie clinică 742

    15 Sindroame eponime 774

    16 Radiologie 800

    17 Intervale de referintă si alte aspecte 832

    18 Proceduri practice 840

    19 Urgente 860

    20 Referinte 936

    Scorul de avertizare timpurie 952

    Stopul cardiac 954


  • 230.00 lei

    50 Studies Every Internist Should Know presents key studies that shape today's practice of internal medicine. Selected using a rigorous methodology, the studies cover topics including: preventative medicine, endocrinology, hematology and oncology, musculoskeletal diseases, nephrology, gastroenterology, infectious diseases, cardiology, pulmonology, geriatrics and palliative care, and mental health. For each study, a concise summary is presented with an emphasis on the results and limitations of the study, and its implications for practice. An illustrative clinical case concludes each review, followed by brief information on other relevant studies. This book is a must-read for health care professionals and anyone who wants to learn more about the data behind clinical practice.

  • 38100lei 260.00 lei

    CURRENT Medical Diagnosis & Treatment is the most comprehensive, reliable, and timely reference available to answer common questions that arise in everyday clinical practice. Readers will find authoritative, evidence-based coverage of more than 1,000 diseases and disorders along with a concise, yet thorough synopsis of diagnosis and treatment.


    Written in a clear, easy-to-read style, this trusted classic covers all aspects of outpatient and inpatient care and includes discussion of new developments and breakthroughs in medicine. Presented in full colour, CMDT covers every aspect of general medicine, with an emphasis on prevention and cost-effective strategies.

    You’ll find authoritative, evidence-based coverage of more than 1,000 diseases and disorders including concise, yet thorough synopsis of diagnosis and treatment. Presented in full-color, this single source reference has been fully updated with the latest developments and breakthroughs in medicine, guidelines, references, drug prices, and more. This essential clinical companion features:

     • A strong emphasis on the practical aspects of clinical diagnosis and patient management

    • Detailed review of all internal medicine disciplines, including geriatrics, preventive medicine, and palliative care, plus gynecology and obstetrics, dermatology, ophthalmology, neurology, psychiatry, and more

    • An annual update on HIV/AIDS and other new, emerging viral infections

     • Specific information regarding disease prevention and prognosis

    • Medication treatment tables, with indexed trade names and updated prices

    • Key recent references on each topic with PMID numbers for quick online access

     • Many full-color photographs, tables, figures and other illustrations Here are some of the many updates and additions:

     • Extensive updating of tables and images

    • New FDA-approved medication for multiple sclerosis

     • New summary of recommended FDA treatment regimens for hepatitis C

     • U.S. Preventive Services Task Force recommendations for osteoporosis, prostate cancer, ovarian cancer, and cervical cancer

    • Extensive update of immune modulation therapy and adjuvant treatments of breast cancer

     • Targeted therapies for advanced non-small cell lung cancers

    • Thoroughly revised chapter on viral and rickettsial infections, including recent measles, polio, and acute flaccid paralysis outbreaks, and on related immunizations

    • Clarification of the appropriate role of opioids and buprenorphine formulations in chronic pain management

    • Revised section on health care for sexual and gender minority patients

     • Information on new biologic agents for asthma, and many other disorders


    Title Page

    Copyright Page




    1. Disease Prevention & Health Promotion

    2. Common Symptoms

    3. Preoperative Evaluation & Perioperative Management

    4. Geriatric Disorders

    5. Palliative Care & Pain Management

    6. Dermatologic Disorders

    7. Disorders of the Eyes & Lids

    8. Ear, Nose, & Throat Disorders

    9. Pulmonary Disorders

    10. Heart Disease

    11. Systemic Hypertension

    12. Blood Vessel & Lymphatic Disorders

    13. Blood Disorders

    14. Disorders of Hemostasis, Thrombosis, & Antithrombotic Therapy

    15. Gastrointestinal Disorders

    16. Liver, Biliary Tract, & Pancreas Disorders

    17. Breast Disorders

    18. Gynecologic Disorders

    19. Obstetrics & Obstetric Disorders

    20. Rheumatologic, Immunologic, & Allergic Disorders

    21. Electrolyte & Acid-Base Disorders

    22. Kidney Disease

    23. Urologic Disorders

    24. Nervous System Disorders

    25. Psychiatric Disorders

    26. Endocrine Disorders

    27. Diabetes Mellitus & Hypoglycemia

    28. Lipid Disorders

    29. Nutritional Disorders

    30. Common Problems in Infectious Diseases & Antimicrobial Therapy

    31. HIV Infection & AIDS

    32. Viral & Rickettsial Infections

    33. Bacterial & Chlamydial Infections

    34. Spirochetal Infections

    35. Protozoal & Helminthic Infections

    36. Mycotic Infections

    37. Disorders Related to Environmental Emergencies

    38. Poisoning

    39. Cancer

    40. Genetic & Genomic Disorders

    41. Sports Medicine & Outpatient Orthopedics

    42. Lesbian, Gay, Bisexual, & Transgender Health


  • 29500lei 270.00 lei

    Now reflecting a greater focus on today's multidisciplinary approach to care, Critical Care Handbook of the Massachusetts General Hospital, 6th Edition, remains your go-to guide for practical, complete, and current information on medical and surgical critical care. The user-friendly, outline format is designed for rapid reference, providing reliable, hospital-tested protocols that reflect today's most advanced critical care practices. Key Features*Heavily revised to reflect today's need to include all care providers to optimize treatment*New section on Health Care Services, with chapters on handovers and transitions, long-term outcomes of ICU patients, EICU and electronic systems, quality improvement, and more*New chapters on critical care management of Ebola virus disease, ECMO and ventricular assist devices, and critical care of the obstetrical patient*New videos available online*Complete, concise, full-color coverage of this rapidly enlarging field*Convenient pocket size for on-the-go referenceNow with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like:*Complete content with enhanced navigation*Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web*Cross-linked pages, references, and more for easy navigation*Highlighting tool for easier reference of key content throughout the text* Ability to take and share notes with friends and colleagues*Quick reference tabbing to save your favorite content for future use

  • Signs & Symptoms in Clinical Practice
    La comanda in aproximativ 4 saptamani
    280.00 lei

    This book on and signs and symptoms, which is indexed in alphabetical order from which the physician will be able to weave a clinical narrative, anatomically and pathophysiologically explicit, to form the accurate diagnostic hypotheses. It is compact, handy and bedside clinical companion book for all dedicated healthcare professionals who are committed to evaluate the patient accurately on the basis of signs and the symptoms. Consists of 91 chapters, enriched with knowledge of about more than 100 contributors. Covers almost all the possible signs and the symptoms, commonly seen in the day-to-day clinical practice. Useful in evaluating the patients in early stages of the complaints and also helpful in initial treatment and management. This book is helpful for undergraduates, postgraduates, residents, and emergency physicians.

  • 290.00 lei

     mprove medical and developmental outcomes in high-risk infants with evidence-based management strategies

    "Beyond the NICU" is the first book to deliver practical, evidence-based strategies for healthcare providers caring for the NICU graduate during convalescence and after discharge. It is a guide to the successful transition of a high-risk infant from intensive care to the intermediate-level nursery, and then, to help the child thrive outside of the hospital in a home environment.

    To advance the standard of care of these vulnerable patients, "Beyond the NICU" draws together clinically focused guidelines to improve patient outcomes and reduce hospital readmissions. Drawing on an international team of respected authorities, "Beyond the NICU" provides the strategies necessary to ensure the success of convalescing NICU graduates in both inpatient and outpatient settings. Doody's Review! Score: 95/100 
    This is a nearly 1,000-page softcover book written by over 100 contributors on convalescent neonatal care and post-discharge care of the high-risk infant. The format is similar to other neonatal handbooks (Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 7th edition, Gomella, et al. (McGraw-Hill, 2013); Manual of Neonatal Care, 7th edition, Cloherty et al. (Lippincott Williams & Wilkins, 2011)), but it emphasizes transitional care of the sick infant. 
    The purpose is to provide "practical, evidence-based strategiesfor the NICU graduate during convalescence and after discharge." The book functions like a practical handbook for clinicians in the NICU, covering almost all aspects of neonatal care, but emphasizing convalescent care. This is an area that has not been well covered in other neonatal books, and this book meets the objectives. 
    The audience is NICU caregivers at all levels and of all disciplines. The book is written in outline format and emphasizes care rather than pathophysiology. The senior editor, his three consultants, and many of the contributors are recognizable names in the field. 
    The 51 chapters are grouped into four sections. After an introductory section which includes chapters on the role of the primary care provider for the NICU graduate, the book covers most aspects of care of preterm and term infants in the next two sections. A final section on developmental care includes chapters on early intervention and palliative care. Although the book is supposed to emphasize convalescent and post-discharge care, much of the second and third sections deals with standard early diagnosis and treatment of common neonatal issues, which adds significant length to the book. The book is at its best when it sticks to its title and emphasizes care "beyond the NICU." Helpful appendixes include discharge checklists, home equipment, and even billing coding for the NICU graduate. Illustrations and tables are sparse, but some are unique and very helpful. 
    This is a unique neonatal book in its emphasis on convalescent and post-discharge care for the sick neonate. It should become a standard text for clinicians in this field and, as it matures in subsequent editions, should abbreviate the acute care sections and concentrate on its title.

  • 34600lei 300.00 lei

    Back by popular demand: the world's most widely-used medical reference, now in its 20th edition. The Merck Manual of Diagnosis and Therapy has been thoroughly updated and expanded with a larger trim size to include 40% new and revised content, including 36 new chapters with more than 200 tables and 100 figures.

    Packed with essential information on diagnosing and treating medical disorders, this comprehensive guide was written by a team of renowned medical experts. It is intended for everyday use by healthcare professionals to ensure delivery of the best care to their patients. The new Merck Manual of Diagnosis and Therapy makes it easy to find the right information at the moment it's needed, with the help of section thumb tabs. It is a must-have for medical students, residents, practicing physicians, nurses, and allied health professionals.

    • New larger trim 7 3/4 x 9 1/4 to accommodate 40% new content
    • 36 completely new chapters
    • Revised and expanded chapters in Cardiovascular, Genitourinary, Gynecologic, Neurologic, Pregnancy, and Infants and Children
    • Pediatrics and trauma section significantly revised and expanded
    • Key Points summarize the facts at-a-glance
    • New Pearls & Pitfalls highlight noteworthy medical info and areas of caution
    • 16-page full-color insert aids visual recognition of skin, eye, and oral disorders

    Table Of Contents:

    Guide for Readers


    Editors and Editorial Board



    1 Nutritional Disorders

    2 Gastrointestinal Disorders

    3 Hepatic and Biliary Disorders

    4 Musculoskeletal and Connective Tissue Disorders

    5 Pulmonary Disorders

    6 Critical Care Medicine

    7 Cardiovascular Disorders

    8 Ear, Nose, and Throat, and Disorders

    9 Dental Disorders

    10 Eye Disorders

    11 Dermatologic Disorders

    12 Hematology and Oncology

    13 Endocrine and Metabolic Disorders

    14 Immunology; Allergic Disorders

    15 Infectious Diseases

    16 Psychiatric Disorders

    17 Neurologic Disorders

    18 Genitourinary Disorders

    19 Gynecology and Obstetrics

    20 Pediatrics

    21 Geriatrics

    22 Clinical Pharmacology

    23 Injuries; Poisoning

    24 Special Subjects


    Ready Reference Guides

    Normal Laboratory Values

    Trade Names of Some Commonly Used Drugs


  • ENT Essentials
    La comanda in aproximativ 4 saptamani
    310.00 lei

    This book is a comprehensive guide to the complete field of otolaryngology for trainees. Divided into seven sections, the manual covers all sub-specialties in ENT practice - ear, face, sleep medicine, laryngology, head and neck, rhinology and allergy, and paediatric ENT. Each section is further divided to discuss the management of various disorders within the subspecialty in question. Highly illustrated with figures and tables to enhance learning, this useful text is edited by respected ENT specialists from University of Pennsylvania School of Medicine and Temple University School of Medicine, Philadelphia. Lead editor, David Kennedy, is past President of the International Rhinology Society. Key Points Comprehensive guide to otolaryngology for trainees Highly illustrated with figures and tables Edited by recognised ENT specialists from Philadelphia Lead editor, David Kennedy, is past President of the International Rhinology Society

  • 35300lei 330.00 lei

    The new edition of this book has been fully revised with the latest advances in anaesthesia practice. Each chapter presents a step by step decision making algorithm with explanatory text and supplemental tables, providing clinicians and trainees with answers for nearly 250 anaesthetic management problems. General principles in anaesthesia care are discussed, as well as detailed examination of preoperative problems, anaesthesia in surgical specialty areas, postoperative management, and perioperative management. The fifth edition includes many new topics including robotic-assisted procedures, heart failure, epilepsy surgery, traumatic brain injury and much more. Authored by respected experts from University of Texas Health Science Centre, the book is enhanced by clinical photographs and diagrams to assist learning. Previous edition published in 2007. Key Points Fully revised, new edition detailing latest advances in anaesthesia practice Chapters presented with step by step decision making algorithm with explanatory text and tables Fifth edition includes many new topics Internationally recognised author team from University of Texas Health Science Centre

  • Clinical Atlas of Diabetes Mellitus
    La comanda in aproximativ 4 saptamani
    42000lei 400.00 lei

  • Conn's Current Therapy 2020
    La comanda in aproximativ 4 saptamani
    44600lei 400.00 lei

    Designed to suit a wide range of healthcare providers, including primary care, subspecialties, and allied health, Conn's Current Therapy has been a trusted clinical resource for more than 70 years.

    The 2020 edition continues this tradition of excellence with current, evidence-based treatment information presented in a concise yet in-depth format. More than 300 topics have been carefully reviewed and updated to bring you state-of-the-art information even in the most rapidly changing areas of medicine.

    ·        Offers personal approaches from recognized leaders in the field, covering common complaints, acute diseases, and chronic illnesses along with the most current evidence-based clinical management options.

    ·        Follows a consistent, easy-to-use format throughout, with diagnosis, therapy, drug protocols, and treatment pearls presented in quick-reference boxes and tables for point-of-care answers to common clinical questions.

    ·        Includes new and significantly revised chapters on neurofibromatosis, autism, psoriatic arthritis, and postpartum depression.

    ·        Features thorough updates in areas critical to primary care, including Acute Myocardial Infarction . Hypertension . Peripheral Arterial Disease . Valvular Heart Disease . Hepatitis C . Irritable Bowel Syndrome . Obsessive Compulsive Disorder . Chronic Obstructive Pulmonary Disease . Fibromyalgia . Menopause . Travel Medicine . and more.

    ·        Provides current drug information thoroughly reviewed by PharmDs.

    ·        Shares the knowledge and expertise of new contributors who provide a fresh perspective in their specialties.

    ·        Features nearly 300 images, including algorithms, anatomical illustrations, and photographs, that provide useful information for diagnosis.

    ·        Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

  • 44600lei 400.00 lei


    Evaluate and treat common fractures and know when to refer uncommon ones to a specialist. This quick, practical resource presents detailed illustrations, video, and current best evidence for imaging and treating fractures so you can make accurate identifications and manage patients with confidence.

    • Quickly find the information you need through a systematic, logical approach to each fracture.
    • Accurately identify fractures through an extensive selection of imaging examples.
    • Apply splints and reduce dislocations successfully thanks to detailed descriptions, illustrations, and narrated video.
    • Tap into the latest best practices through evidence-based coverage and updated references.
    • Effectively manage emergency situations using guidelines for emergent referral, greater detail regarding methods for closed reductions for fractures and dislocations, and more.
    • Benefit from expanded content specifically for the emergency medicine setting, including CT, MRI, and ultrasound imaging, procedural sedation, and discharge reassessment.


    ·         ·  1.  Fracture management in primary care and emergency medicine settings

    ·         ·  Primary care physicians

    ·         ·  Emergency medicine physicians

    ·         ·  Nurse practitioners and physician assistants

    ·         ·  References

    ·         ·  2.  General principles of fracture care

    ·         ·  Bone composition

    ·         ·  Fracture healing

    ·         ·  Potential fracture sites

    ·         ·  Fracture description

    ·         ·  Fracture selection and referral guidance

    ·         ·  Overview of acute management

    ·         ·  Overview of definitive care

    ·         ·  Late fracture complications

    ·         ·  Management of pediatric fractures

    ·         ·  References

    ·         ·  3.  Finger fractures

    ·         ·  Distal phalanx fractures

    ·         ·  Mallet finger

    ·         ·  Flexor digitorum profundus avulsion (Jersey finger)

    ·         ·  Distal interphalangeal joint dislocation

    ·         ·  Middle phalanx shaft fractures (adult)

    ·         ·  Middle phalanx fractures (pediatric)

    ·         ·  Proximal interphalangeal joint injuries

    ·         ·  Avulsion of the central slip of the extensor tendon (boutonniere injury)

    ·         ·  Lateral avulsion fractures

    ·         ·  Proximal interphalangeal joint dislocation

    ·         ·  Proximal phalanx shaft fractures (adult)

    ·         ·  Pediatric (physeal) fractures of the proximal phalanx

    ·         ·  Dislocations and ligament injuries of the metacarpophalangeal joint

    ·         ·  Dislocations and ligament injuries of the thumb metacarpophalangeal joint

    ·         ·  References

    ·         ·  4.  Metacarpal fractures

    ·         ·  Metacarpal head

    ·         ·  Metacarpal neck

    ·         ·  Metacarpal shaft

    ·         ·  Metacarpal base

    ·         ·  Dislocations of the carpometacarpal joint

    ·         ·  First metacarpal fractures (adult)

    ·         ·  First metacarpal fractures (pediatric)

    ·         ·  References

    ·         ·  5.  Carpal fractures

    ·         ·  Scaphoid fractures (adult)

    ·         ·  Scaphoid fractures (pediatric)

    ·         ·  Triquetrum fractures

    ·         ·  Lunate fractures

    ·         ·  Hamate fractures

    ·         ·  Capitate fractures

    ·         ·  Pisiform fractures

    ·         ·  Trapezium fractures

    ·         ·  Trapezoid fractures

    ·         ·  Carpal dislocations

    ·         ·  References

    ·         ·  6.  Radius and ulna fractures

    ·         ·  Distal radius fractures (adult)

    ·         ·  Distal radius fractures (pediatric)

    ·         ·  Metaphyseal fractures

    ·         ·  Physeal fractures

    ·         ·  Fractures of the shaft of the radius (adult): Galeazzi fracture

    ·         ·  Fractures of the shaft of the radius (pediatric)

    ·         ·  Both-bone forearm fractures (adult)

    ·         ·  Both-bone forearm fractures (pediatric)

    ·         ·  Fractures of the ulnar shaft

    ·         ·  Monteggia fractures (adult)

    ·         ·  Monteggia fractures (pediatric)

    ·         ·  Wrist dislocations (radiocarpal joint)

    ·         ·  References

    ·         ·  7.  Elbow fractures

    ·         ·  Radial head and neck

    ·         ·  Olecranon

    ·         ·  Coronoid process

    ·         ·  Distal humerus (adult)

    ·         ·  Supracondylar and transcondylar fractures

    ·         ·  Intercondylar fractures

    ·         ·  Condylar fractures

    ·         ·  Medial epicondyle fractures

    ·         ·  Distal humerus (pediatric)

    ·         ·  Supracondylar fractures

    ·         ·  Lateral condyle fractures

    ·         ·  Medial epicondyle fractures

    ·         ·  Little league elbow

    ·         ·  Elbow dislocation

    ·         ·  References

    ·         ·  8.  Humerus fractures

    ·         ·  Anatomic considerations

    ·         ·  Proximal humerus fractures (adult)

    ·         ·  Proximal humerus fractures (pediatric)

    ·         ·  Midshaft fractures of the humerus

    ·         ·  Shoulder (glenohumeral) dislocations

    ·         ·  References

    ·         ·  9.  Clavicle and scapula fractures

    ·         ·  Clavicle fractures

    ·         ·  Fractures of the middle third of the clavicle

    ·         ·  Fractures of the distal third of the clavicle

    ·         ·  Fractures of the proximal third of the clavicle

    ·         ·  Scapula fractures

    ·         ·  References

    ·         ·  10.  Spine fractures

    ·         ·  Cervical spine fractures (adult)

    ·         ·  Cervical spine fractures (pediatric)

    ·         ·  Thoracolumbar spine fractures (adult)

    ·         ·  Compression fractures

    ·         ·  Spinous process and transverse process fractures

    ·         ·  Burst fractures

    ·         ·  Thoracolumbar spine fractures (pediatric)

    ·         ·  Spondylolysis

    ·         ·  Nontraumatic thoracolumbar fractures

    ·         ·  Tumors

    ·         ·  Vertebral osteomyelitis

    ·         ·  References

    ·         ·  11.  Femur and pelvis fractures

    ·         ·  Femoral neck fractures

    ·         ·  Intertrochanteric fractures

    ·         ·  Trochanteric fractures

    ·         ·  Femoral shaft fractures

    ·         ·  Stress fractures of the femur

    ·         ·  Hip dislocations

    ·         ·  Pelvic fractures

    ·         ·  Acetabular fractures

    ·         ·  References

    ·         ·  12.  Patellar, tibial, and fibular fractures

    ·         ·  Patellar fractures and dislocations

    ·         ·  Patellar dislocation

    ·         ·  Tibial fractures

    ·         ·  Tibial plateau fractures

    ·         ·  Disposition

    ·         ·  Tibial shaft fractures

    ·         ·  Stress fractures of the tibia

    ·         ·  Fractures of the shafts of the tibia and fibula

    ·         ·  Fibular fractures

    ·         ·  Stress fractures of the fibula

    ·         ·  References

    ·         ·  13.  Ankle fractures

    ·         ·  Ankle fractures (adult)

    ·         ·  Ankle fractures (pediatric)

    ·         ·  Distal tibial fractures (pediatric)

    ·         ·  Distal fibular fractures (pediatric)

    ·         ·  Ankle dislocation

    ·         ·  References

    ·         ·  14.  Calcaneus and other tarsal fractures

    ·         ·  Calcaneus fractures (adult)

    ·         ·  Extraarticular fracture: Anterior process

    ·         ·  Extraarticular fracture: Medial or lateral process

    ·         ·  Extraarticular fracture: Tuberosity

    ·         ·  Extraarticular fracture: Sustentaculum tali

    ·         ·  Extraarticular fracture: Body not involving the subtalar joint

    ·         ·  Intraarticular fractures

    ·         ·  Calcaneus stress fractures

    ·         ·  Calcaneus fractures (pediatric)

    ·         ·  Talus fractures (adult)

    ·         ·  Osteochondral dome fractures

    ·         ·  Fracture of the lateral process of the talus (snowboarder’s fracture)

    ·         ·  Talus fractures (pediatric)

    ·         ·  Navicular fractures (adult)

    ·         ·  Navicular stress fracture

    ·         ·  Navicular fractures (pediatric)

    ·         ·  Cuboid and cuneiform fractures

    ·         ·  References

    ·         ·  15.  Metatarsal fractures

    ·         ·  Fractures of the metatarsal shafts

    ·         ·  Stress fractures of the metatarsal shafts

    ·         ·  Proximal fractures of the first through fourth metatarsals

    ·         ·  Fractures of the proximal fifth metatarsal

    ·         ·  Avulsion fractures of the styloid

    ·         ·  Fractures of the metaphyseal–diaphyseal junction

    ·         ·  Stress fracture of the fifth metatarsal diaphysis

    ·         ·  References

    ·         ·  16.  Toe fractures

    ·         ·  Toe fractures

    ·         ·  Toe dislocations

    ·         ·  Sesamoid fractures

    ·         ·  References

    ·         ·  17.  Facial and skull fractures

    ·         ·  Nasal fractures

    ·         ·  Fractures of other facial bones

    ·         ·  Skull fractures

    ·         ·  References

    ·         ·  18.  Rib fractures

    ·         ·  Anatomic considerations

    ·         ·  Mechanism of injury

    ·         ·  Rib fractures after trauma

    ·         ·  Stress fractures of the ribs

    ·         ·  References

  • 420.00 lei



    Ideal for residency, fellowship, clinical practice, and board review, the National Kidney Foundation’s Primer on Kidney Diseases, 7th Edition, by Drs. Scott J. Gilbert and Daniel E. Weiner, offers comprehensive coverage of adult and pediatric kidney diseases in an authoritative, practical resource. Well organized and highly readable, it covers every relevant topic in the field, from anatomy, physiology, and pathophysiology, to diagnosis and management of kidney disease, to fluid and electrolyte disorders, hypertension, dialysis, and renal transplantation.


    Trusted by nephrologists at all levels of experience for nearly 25 years, this powerful learning tool and clinical reference is a joint publication of Elsevier and the National Kidney Foundation.

    New To This Edition:

    Thoroughly covers hot topics in this fast-changing field, including ongoing clinical research and changing treatment protocols.

    A new chapter on inherited kidney diseases, with a specific focus on APOL1 and the implications of APOL1 carrier status for kidney disease in African-Americans.

    A new approach to membranoproliferative glomerulonephritis, focusing on the role of complement as a way to approach both the diagnosis and treatment of these diseases.

    Additions to the chapter on hemodialysis, specifically incorporating information on hemodiafiltration.

    Updates in the management of hypertension, incorporating results from SPRINT and ACCORD as well as data on treatment of renal artery sclerosis and renal denervation into the approach for blood pressure management.

    Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

    Table Of Contents:

    Structure and Function of the Kidney

    1. Overview of Kidney Structure and Function

    2. Kidney development

    3. Assessment of Kidney Function in Acute and Chronic Settings

    4. Urinalysis and Urine Microscopy

    5. Hematuria and Proteinuria

    6. Imaging the Kidneys

    Acid/Base and Electrolytes

    7. Hyponatremia and Hypoosmolar Disorders

    8. Hypernatremia

    9. Volume, Edema and the Clinical Use of Diuretics

    10. Disorders of Potassium Metabolism

    11. Disorders of Calcium, Phosphorus, & Magnesium Homeostasis

    12. Approach to Acid-Base Disorders

    13. Metabolic Acidosis

    14. Metabolic Alkalosis

    15. Respiratory Acidosis and Alkalosis

    Glomerular Diseases

    16. Glomerular Clinicopathologic Syndromes

    17. Minimal Change Nephrotic Syndrome

    18. Focal Segmental Glomerulosclerosis

    19. Membranous Nephropathy

    20. Immunoglobulin A Nephropathy and Related Disorders

    Kidney in Systemic Diseases


    22. Infection-related Glomerulonephritis

    23. Viral Nephropathies: Human Immunodeficiency Virus, Hepatitis C Virus, and Hepatitis B Virus

    24. Kidney Involvement in Systemic Vasculitis

    25. Systemic Lupus Erythematosus and the Kidney

    26. Pathogenesis, Pathophysiology, and Treatment of Diabetic Nephropathy

    27. The Kidney in Malignancy

    28. Myeloma, Amyloid and other Dysproteinemias

    29. Acute Cardiorenal Syndrome

    30. Hepatorenal Syndrome and Other Liver-Related Kidney Diseases

    Acute Kidney Injury

    31. Clinical Approach to the Diagnosis of Acute Kidney Injury

    32. Acute Tubular Injury and Acute Tubular Necrosis

    33. Acute Interstitial Nephritis

    34. Management of Acute Kidney Injury

    Drugs and the Kidney

    35. Kidney Disease Caused by Therapeutic Agents

    36. Principles of Drug Therapy in Patients with Reduced Kidney Function

    Hereditary Kidney Disease

    37. Genetics and Kidney Disease (APOL1)

    38. Genetically Based Renal Transport Disorders

    39. Sickle Cell Nephropathy

    40. Polycystic and Other Cystic Kidney Diseases

    41. Nephronophthisis and Medullary Cystic Kidney Disease

    42. Alport’s Syndrome and Thin Basement Membrane Dz

    43. Fabry Disease

    Tubulointerstitial Diseases

    44. Chronic Tubulointerstitial Disease

    45. Obstructive Uropathy

    46. Nephrolithiasis

    47. Urinary Tract Infection and Pyelonephritis

    Special Circumstances

    48. Kidney Diseases in Infants and Children

    49. The Kidney in Pregnancy

    50. Kidney Disease in the Elderly

    51. Global Kidney Disease

    Chronic Kidney Disease

    52. Development and Progression of Chronic Kidney Disease

    53. Staging and Management of Chronic Kidney Disease

    54. Nutrition and Kidney Disease

    55. Bone Disorders in Chronic Kidney Disease

    56. Cardiac Function and Cardiovascular Disease in Chronic Kidney Disease

    57. Anemia and Other Hematologic Complications of Chronic Kidney Disease

    Dialysis and Transplantation

    58. Hemodialysis and Hemofiltration

    59. Peritoneal Dialysis

    60. Outcome of End-Stage Renal Disease Therapies

    61. Selection of Prospective Kidney Transplant Recipients and Donors

    62. Post-transplantation Monitoring and Outcomes

    63. Immunosuppression

    64. Transplant Infectious Disease


    65. Pathogenesis of Hypertension

    66. Evaluation and Management of Hypertension

    67. Secondary Hypertension



  • 56000lei 500.00 lei

    The first edition of this book, published in 2009, was the only book of its kind dedicated exclusively to the diagnosis and management of pulmonary arterial hypertension (PAH) in patients with interstitial lung disease (ILD). Over the past few years, new diagnostic tests and treatments of pulmonary arterial hypertension have been developed and tested. Diagnostic testing has led to more frequent and specific diagnosis in PAH patients, leading to the more widespread use of effective treatment and improved quality of life and reduction of mortality for PAH patients. Pulmonary Hypertension and Interstitial Lung Disease: A Clinical Guide, Second Edition provides an updated and expanded state-of-the-art overview of the problems seen by physicians in the clinical management of ILDs. The first section of the book discusses general features and includes an overview of clinical features, diagnosis and pathology of ILD. The second part discusses specific disorders such as idiopathic pulmonary fibrosis, sarcoidosis, and hypersensitivity pneumonia. Pulmonary Hypertension and Interstitial Lung Disease, Second Edition is an invaluable resource for all physicians whose practice involves the care and treatment of patients with interstitial lung disease. The first edition of this book, published in 2009, was the only book of its kind dedicated exclusively to the diagnosis and management of pulmonary arterial hypertension (PAH) in patients with interstitial lung disease (ILD). Over the past few years, new diagnostic tests and treatments of pulmonary arterial hypertension have been developed and tested. Diagnostic testing has led to more frequent and specific diagnosis in PAH patients, leading to the more widespread use of effective treatment and improved quality of life and reduction of mortality for PAH patients. Pulmonary Hypertension and Interstitial Lung Disease: A Clinical Guide, Second Edition provides an updated and expanded state-of-the-art overview of the problems seen by physicians in the clinical management of ILDs. The first section of the book discusses general features and includes an overview of clinical features, diagnosis and pathology of ILD. The second part discusses specific disorders such as idiopathic pulmonary fibrosis, sarcoidosis, and hypersensitivity pneumonia. Pulmonary Hypertension and Interstitial Lung Disease, Second Edition is an invaluable resource for all physicians whose practice involves the care and treatment of patients with interstitial lung disease.

  • 57700lei 510.00 lei



    A practical resource covering both elective and emergency procedures for the practicing vascular and endovascular clinician

    This book provides medical professionals (vascular surgeons, interventional cardiologists, interventional radiologists, endovascular neurologists, vascular medicine specialists) with a reference guide to the most common and accepted approach to endovascular management of peripheral vascular disease. It also addresses urgent interventions in the acute setting of the various vascular beds, and covers emerging areas such as stroke intervention and endovascular treatment of pulmonary embolism and vascular trauma.

    Edited by a multidisciplinary team, Endovascular Interventions offers in-depth coverage of the field in seven parts: Overview; Supra-Aortic Intervention in High Risk Patients: Innominate, Subclavian, Carotid, Vertebral and Intracranial Interventions; Interventions of the Aorta; Renal and Mesenteric Interventions; Lower Extremity Interventions; Venous Disease; and Vascular Trauma. Each section covers the technical aspects of the procedures as well as the fundamental clinical aspects which are necessary in the evaluation of patients considered for interventions. Chapters feature illustrations, case studies, key learning points, equipment lists, and sample questions and answers which can be used for Board exam practice.

    ·         Practical review of vascular and endovascular medicine covering both elective and emergency procedures

    ·         Illustrated, templated chapters provide rapid answers to questions and include case studies, key learning points, and equipment lists

    ·         Includes sample questions and answers that are handy for Board exam practice

    ·         Edited by multidisciplinary experts

    Endovascular Interventions is an excellent review book for all practicing and aspiring vascular and endovascular specialists.



    List of Contributors vii

    1 Vascular Biology 1
    Cristina Sanina, Olga L. Bockeria, Karlo A. Wiley and Jonathan E. Feig

    2 Non-Invasive Testing in Peripheral Arterial Disease 17
    Ian Del Conde and James F. Benenati

    3 Carotid and Innominate Artery Stenting for High-Risk Patients 25
    Reid Ravin, Shivani Kumar and Peter Faries

    4 Subclavian Artery Stenosis: When and How to Intervene 37
    Parham Parto and Tyrone J. Collins

    5 Vertebral Artery Occlusive Disease 45
    Mark H.Wholey and Jason M. Andrus

    6 Stroke Interventions 53
    Italo Linfante

    7 Endovascular Management of Thoracoabdominal Aneurysms 61
    William E. Beckerman and James F. McKinsey

    8 Abdominal Aortic Aneurysms: Catheter-Based Interventions 77
    Sean P. Wengerter, Kurt R. Wengerter and Michael L. Marin

    9 Aortic Dissection: Urgent Endovascular Treatment 99
    Ratna C. Singh and Evan C. Lipsitz

    10 Management of Acute Aortic Syndrome 111
    Rajesh Malik, Michael Siah and Edward Y.Woo

    11 Severe Renal Artery Stenosis:When and How to Intervene 121
    Jose D. Tafur and Christopher J.White

    12 Mesenteric Ischemia: Chronic and Acute Management 135
    Vincent Gallo, Kevin “Chaim” Herman and John H. Rundback

    13 Catheter-Based Management of Peripheral AVMs 143
    Allan M. Conway, Alfio Carroccio and Robert J. Rosen

    14 Aortoiliac Interventions 15
    Subhash Banerjee, Houman Khalili and Mehdi Shishehbor

    15 Femoropopliteal Interventions in the Claudicant Patient 167
    Pedro A. Villablanca, Cristina Sanina, Pedro R. Cox-Alomar, Prakash Krishnan and Jose M.Wiley

    16 Tibial and Pedal Plantar Interventions in Patients with Critical Limb Ischemia 183
    Anand Prasad and Haley Hughston

    17 The Diagnosis, Evaluation and Contemporary Management of Acute Limb Ischemia 207
    Michael N. Young and Douglas E. Drachman

    18 Pedal Reconstruction in Critical Limb Ischemia 221
    Amjad AlMahameed and Craig Walker

    19 Access Site Complications 227
    Miguel Alvarez Villela, Fernando D. Pastor and Robert T. Pyo

    20 Acute Deep Vein Thrombosis 243
    Ian Del Conde and James F. Benenati

    21 Chronic Venous Disorders 251
    Brett J. Carroll, Duane S. Pinto and Cristina Sanina

    22 Endovascular Treatment of Pulmonary Embolism 267
    Ian Del Conde and Barry T. Katzen

    23 Inferior Vena Cava Filters 275
    Merrill H. Stewart and James S. Jenkins

    24 Endovascular Treatment for Vascular Trauma 291
    Hallie E. Baer-Bositis, Georges M. Haidar, Taylor D. Hicks and Mark G. Davies

    Index 307



  • Rheumatoid Arthritis and Proteus
    La comanda in aproximativ 4 saptamani
    62000lei 560.00 lei

    Rheumatoid Arthritis and Proteus explores the idea that Rheumatoid arthritis is caused by a urinary tract infection as a result of Proteus bacteria. Rheumatoid arthritis is a severe, painful and crippling disease affecting millions of people throughout the world, especially women. Genetic studies over the last 30 years have shown that individuals who possess the white cell blood groups HLA-DR1/4 carry a susceptibility sequence and are more likely to develop the disease. This book uses the methods of Sir Karl Popper, the philosopher of science, to present 12 “Popper sequences” which have been identified to indicate that Proteus is the causative agent of Rheumatoid Arthritis. Rheumatoid Arthritis and Proteus proposes that Anti-Proteus therapies should be followed as early as possible to prevent the crippling and irreversible joint deformities that occur in Rheumatoid Arthritis.

  • 60600lei 560.00 lei

    Obesity is considered a complex and multifactorial disease. Its treatment, therefore, must also be multimodal and tailored to meet the needs of each patient.

    Obesity: Evaluation and Treatment Essentials presents a wide spectrum of practical treatment protocols for obesity including exercise, pharmacology, behavior modification, and dietary factors, from the point of view of the practicing physician. The book includes information about the new pharmacotherapy available for the treatment of obesity. It also includes a chapter on medical treatment of pediatric obesity that identifies the special needs of children and outlines approaches for managing the obese child. A chapter on binge eating disorder has been added and the information on pharmacology of bariatric medicine has been updated.

    The book addresses various dietary interventions such as low-calorie balanced diets, low-carbohydrate diets, and very-low-carbohydrate diets while also exploring the comorbidities of obesity such as hypertension, cardiovascular disease, and Type II diabetes.
    Written by prominent members of the Obesity Medicine Association and a multidisciplinary team of clinicians and researchers, the book showcases successful treatment methods by including personal key points by clinicians in each chapter. This comprehensive resource is an invaluable, user-friendly tool for bariatric physicians and surgeons, endocrinologists, diabetologists, nutritionists, and dieticians, as well as all other professionals who currently treat obesity.

  • 580.00 lei

    This book introduces the advanced topics regarding renal failure including manifold findings of physiologic, pathophysiologic and clinical aspects in the kidney. The kidney plays a crucial physiologic role in the regulation of urinary formation, fluid balance, nutrition metabolism, blood pressure and other aspects in the living body. Renal failure is a condition of a decline or loss of kidney function due to deficiency of functioning nephrons. Acute renal failure is a syndrome, which is characterized by acute decline or loss of kidney function due to temporary disfunctioning or blocking of nephrons. Acute renal failure is a reversible condition and is a secondary manifestation, a complication of another underlying critical illness. Chronic renal failure is a condition of slow, gradual decline of kidney function due to irreversible destruction of nephrons. This book provides recent information concerning acute and chronic renal failure in clinical aspects, and is constituted in five chapters.

  • 63500lei 580.00 lei

     Respiratory problems are the most common cause of acute admission to hospital. A variety of diagnostic investigations are required, both for acute and clinic assessment. Making Sense of Lung Function Tests, Second Edition familiarises both trainees and more experienced clinicians with the interpretation of a range of respiratory parameters. It places lung function in a clinical context using real-life examples and provides invaluable hands-on guidance.

    For this second edition Consultant Respiratory Physician Jonathan Dakin and Consultant Anaesthetist Elena Kourteli are joined by Mark Mottershaw, Chief Respiratory Physiologist from Queen Alexandra Hospital, Portsmouth, all contributing a broad range of expertise and perspectives. Together they have updated the book throughout and added new chapters including an algorithm for interpretation of pulmonary function tests, exhaled nitric oxide (FENO) and cardiopulmonary exercise testing.

    The text offers a clear explanation of the concepts which students find difficult, including:


    • The basis of obstructive and restrictive defects


    • Pattern recognition of the flow volume loop


    • Differences between TLCO and KCO


    • Assessment of oxygenation using POand SO2


    • The basis of Type 1 and type 2 respiratory failure


    • Distinguishing respiratory and metabolic acidosis


    • The relationship between sleep and respiratory failure

    The information is presented in an accessible way, suitable for those seeking a basic grounding in spirometry or blood gases, but also sufficiently comprehensive for readers completing specialist training in general or respiratory medicine.

  • 67400lei 580.00 lei

    This textbook provides a comprehensive, state-of-the art review of the field of hernia surgery, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in both inguinal and ventral/incisional hernia. This book provides an overview of the current understanding of the biologic basis of hernia formation as well as laying the foundation for the importance of hernia research and evaluating outcomes in hernia repair. Diagnosis and management strategies for inguinal and ventral hernia are discussed in detail with separate techniques sections for the most widely used procedures in this field as well as emerging technologies such a robotic and single incision surgery.

    Pertinent associated topics to inguinal hernia surgery such as chronic groin and athletic pubalgia are covered in detail. For incisional hernias, associated topics such as hernia prevention and enhanced recovery protocols are discussed. For both inguinal and ventral/incisional hernias mesh choices and available mesh technologies are discussed in detail as this remains an often confusing matter for the general surgery. When appropriate, chapters to highlight controversies in care are featured such as the use of synthetic mesh in contaminated surgery and laparoscopic closure of defects in laparoscopic ventral hernia repair.

    Current recommendations and outcomes data are highlighted when available for each technique. Textbook of Surgery will serve as a very useful resource for physicians and researchers dealing with, and interested in, abdominal wall hernias. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.

  • 70000lei 650.00 lei

     This new book on vascular malformations brings together international experts to present advances and discuss controversies in the multidisciplinary management of patients with congenital vascular malformations.

    Major advances in recent years in medical genetics, and tremendous progress in the fields of imaging and minimally invasive percutaneous interventions have revolutionized both evaluation and management of vascular malformations. The six major parts of this state of the art book ensure that the reader has the most up to date valuable clinical information to ensure the delivery of world class clinical practice. Beautifully illustrated with color line drawings, numerous photographs and informative tables, the advances and controversies of the full spectrum of vascular malformations are presented in 90 definitive chapters.

    Vascular Malformations brings new information and unparalleled insights to vascular specialists and physicians, trainees and allied health professionals who participate in the care of patients with vascular malformations, either in a private practice setting or at a major institution in an interdisciplinary vascular center.

    Table of Contents

    Foreword Hugo Partsch

    Preface BB Lee, Peter Gloviczki & Francine Blei

    Part 1. Congenital Vascular Malformations (CVMs) in General

    Section 1. Definition & Classification

    Chapter 1. ISSVA Classification: Controversy with the benefit and liability.

    Raul Mattassi

    Chapter 2. Hamburg Classification: Controversy with the benefit and liability.

    Peter Gloviczki & David Driscoll

    Chapter 3. Syndromic classification of Congenital Vascular Malformations: how useful is it?

    Francine Blei

    Chapter 4. Consensus on the contemporary classification.

    BB Lee & Leonel Villavicencio

    Section 2. Diagnosis

    Chapter 5. How extensive study should be included in initial assessment for the Congenital Vascular Malformations?

    BB Lee & James Laredo

    Chapter 6. Should hemangiomas be included in the initial differential diagnosis for Congenital Vascular Malformations?

    Francine Blei

    Chapter 7. How much the genetic studies should be incorporated for Venous Malformations and Arterio-Venous Malformations assessment, and when?

    Sandro Michelini, Stefano Paolacci & Matteo Bertelli

    Chapter 8. Indications for genetic testing in the evaluation of Lymphatic and Hemolymphatic Malformations.

    Stanley G. Rockson

    Section 3. Management

    Chapter 9. The importance of interdisciplinary team approach for evaluation and

    management of Vascular Malformations.

    Megha M. Tollefson, Peter Gloviczki & David Driscoll

    Chapter 10. How will genetics influence the management of Vascular Malformations?

    Francine Blei

    Part 2. Arterio-Venous Malformations (AVMs)

    Section 4. Definition & Classification

    Chapter 11. Confusion with Arterio-Venous fistula versus Arterio-Venous Malformation of ISSVA Classification.

    Dirk Loose

    Chapter 12. Nidus or no nidus: Is it a crucial issue for diagnostic assessment for the Arterio-Venous Malformations?

    Furuzan Numan

    Chapter 13. New classification of the Arterio-Venous Malformations based on arteriographic findings: How much worthy?

    YoungSoo Do & Kwang Bo Park

    Section 5. Diagnosis

    Chapter 14. Arteriographic assessment: Is it still a gold standard for the Arterio-Venous Malformations diagnosis?

    Hendrik von Tengg-Kobligk, Iris Baumgartner, Sabrina Frey & Dominik Obrist

    Chapter 15. Ultrasonographic assessment: New role for the Arterio-Venous Malformations. How far can it be implied?

    Erica Menegatti & Sergio Gianesini

    Chapter 16. Magnetic Resonance (MR) Angiography and/or Computed Tomography (CT) Angiography: New gold standard for the Arterio-Venous Malformations?

    Massimo Vaghi

    Chapter 17. Transarterial Lung Perfusion Scintigraphy (TLPS): New role for the follow up


    Raul Mattassi

    Section 6. Management - 1

    Chapter 18. Do all the Arterio-Venous Malformations mandate the therapy? Is there any contraindication for the therapy?

    BB Lee & James Laredo

    Chapter 19. How much is too much for the Arterio-Venous Malformation management?

    Young-Wook Kim

    Chapter 20. Ethanol sclerotherapy- Is it gold standard for the Arterio-Venous Malformation management?

    Iris Baumgartner, Mihai Constatntinescu, Jochen Rössler & Hendrik von Tengg

    Chapter 21. N-Butyl Cyanoacrylate versus Onyx embolotherapy.

    Furuzan Numan

    Section 7. Management - 2

    Chapter 22. Surgical therapy combined with embolo/sclerotherapy - Multidisciplinary


    Paul Marji, James Laredo & BB Lee

    Chapter 23. Indication for the amputation for the Arterio-Venous Malformation - proper option?

    Young-Wook Kim

    Chapter 24. How much pharmacological therapy can be incorporated to the Arterio-Venous Malformation management?

    Jochen Karl Rössler & Iris Baumgartner

    Chapter 25. Secondary changes in Arterio-Venous Malformations: arteries, veins, tissues, bones; when do they have to be treated?

    Dirk Loose

    Part 3. Venous Malformations (VMs)

    Section 8. Definition & Classification

    Chapter 26. (Capillary & Cavernous) Hemangioma and Venous Malformations.

    BB Lee & James Laredo

    Chapter 27. Angiographic classification of the Venous Malformations based on venous drainage status: How much worthy?

    Kwang Bo Park & Young Soo Do

    Section 9. Diagnosis

    Chapter 28. Ultrasonographic assessment: Mandatory test to lead the assessment of the Venous Malformations?

    Pier Luigi Antignani

    Chapter 29. Conventional and Dynamic Contrast Enhanced Magnetic Resonance Imaging (dceMRI) and/or Magnetic Resonance Venography: diagnostic modalities with different objectives? Can they replace phlebography?

    Jovan Markovic & Cynthia Shortell

    Chapter 30. Computed Tomography (CT) and CT Venography: how are these modalities different from Magnetic Resonance Imaging (MRI) for evaluation of Venous Malformations?

    Jovan Markovic & Cynthia Shortell

    Chapter 31. Whole Body Blood Pool Scintigraphy (WBBPS) - Special role for the management of Venous Malformations?

    Raul Mattassi

    Section 10. Management -1

    Chapter 32. Do all the Venous Malformations require treatment?

    Kurosh Parsi & Mina Kang

    Chapter 33. How much is too much for the Venous Malformations management?

    Pier Luigi Antignani

    Chapter 34. What is the first option for the Venous Malformations management?

    Sarah Bernhard, Aleksandra Tuleja, Jochen Rössler & Iris Baumgartner

    Chapter 35. Ethanol sclerotherapy- Is it gold standard for the Venous Malformations management as well?

    YoungSoo Do

    Chapter 36. Foam Sclerotherapy- First option for Venous Malformations?

    Kurosh Parsi & Mina Kang

    Chapter 37. Considerations regarding feasibility, safety and efficacy of N-Butyl Cyanoacrylate (n-BCA) and Onyx embolization for the treatment of Venous Malformations.

    Jovan Markovic & Cynthia Shortell

    Section 11. Management -2

    Chapter 38. Surgical therapy of Venous Malformations combined with embolo/sclerotherapy: How much and when?

    Dirk Loose

    Chapter 39. How aggressive the management of vascular bone syndrome caused by the Venous Malformations should be?

    Raul Mattassi

    Chapter 40. To what extent should anticoagulation therapy be considered to the Venous Malformations?

    Alfonso Tafur, Evi Kalodiki & Jawed Fareed

    Chapter 41. How to approach on Marginal Vein combined with deep vein hypoplasia/ aplasia?

    Dirk Loose

    Chapter 42. Indication for the amputation for extensive Venous Malformations - proper


    Dirk Loose

    Chapter 43. How much pharmacological therapy can be incorporated to the Venous Malformations management?

    Francine Blei

    Part 4. Lymphatic Malformations (LMs)

    Section 12. Definition & Classification

    Chapter 44. Confusion on the Terminology- Primary Lymphedema and Lymphangioma /Lymphatic Malformations

    James Laredo & BB Lee

    Chapter 45. Contemporary diagnosis of Primary Lymphedema and Lymphatic Malformations

    Stanley G. Rockson

    Chapter 46. Clinical staging of lymphedema - How practical for clinical management of

    Primary Lymphedema?

    Sandro Michelini, Alessandro Fiorentino, Alessandro Failla & Giovanni Moneta

    Chapter 47. Laboratory (lymphoscintigraphic) staging- Guideline?

    BB Lee & James Laredo

    Section 13. Diagnosis

    Chapter 48. Ultrasonographic assessment of the Lymphatic Malformations : Lymphangioma & Primary Lymphedema - A new role for the diagnosis?

    Erica Menegatti & Sergio Gianesini

    Chapter 49. Radionuclide Lymphoscintigraphy (LSG) - Gold standard for the assessment of

    the Lymphatic Malformations: Lymphangioma & Primary Lymphedema, BOTH?

    Vaughan Keeley

    Chapter 50. Magnetic Resonance Imaging (MRI) and Magnetic Resonance Lymphangiography of Primary Lymphedema - A new gold standard?

    NingFei Liu

    Chapter 51. Indocyanine Green (ICG) Fluorescent Lymphography- Clinical implementation

    Takumi Yamamoto

    Chapter 52. Oil Contrast Lymphangiography - New role for the surgical candidate?

    Francesco Boccardo, Sara Dessalvi, Campisi Corrado Cesare & Campisi Corradino

    Chapter 53. Fluorescent microlymphangiography: Controversial - confusion and neglected problems

    Claudio Allegra, Michelangelo Bartolo & Salvino Bilancini

    Chapter 54. Can Indocyanine Green (ICG) Fluorescent Lymphography replace the role of Lymphoscintigraphy (LSG)?

    Takumi Yamamoto

    Chapter 55. How to differentiate between the Lymphedema and Lipedema. How to rule out the Lipedema?

    Győző Szolnoky

    Section 14. Management- 1: Primary Lymphedema

    Chapter 56. Manual Lymphatic Drainage (MLD) - Myth?

    Isabel Forner Cordero & Jean Paul Belgrado

    Chapter 57. Compression therapy- Optimal Pressure? Bandage versus stocking.

    Isabel Forner Cordero & Jean Paul Belgrado

    Chapter 58. Sequential Intermittent Pneumatic Compression (SIPC) - Rationale? How much it can be incorporated to compression therapy?

    Isabel Forner Cordero & Jean Paul Belgrado

    Chapter 59. Reconstructive surgery: Lymphovenous anastomosis versus lymph-node transplantation. Can they stay as an independent therapy option? Indications & Contraindications?

    Corradino Campisi, Francesco Boccardo, Melissa Ryan, Michele Maruccia, Fabio Nicoli, Pietro Di Summa & Corrado Cesare Campisi

    Chapter 60. Excisional surgery: when and how much it can be incorporated?

    Justin Chin-Bong Choi, James Laredo & BB Lee

    Chapter 61. Multidisciplinary approach with liposuction in Primary Lymphedema: Is there a difference compared to patients with Secondary Lymphedema?

    Robert Damstra & Håkan Brorson

    Chapter 62. How much pharmacological therapy can be incorporated to the Primary Lymphedema management?

    Vaughan Keeley and Neil Piller

    Chapter 63. What is the difference in the management of Primary Lymphedema between the

    adults and children, and how much?

    Miguel Amore & Cristobal Papendieck

    Chapter 64. How to manage the Lipedema involved to Primary lymphedema?

    Győző Szolnoky

    Chapter 65. How to assess the response/efficacy of manual lymphatic drainage and

    compression therapy.

    Győző Szolnoky

    Chapter 66. How to assess the efficacy of Lipedema management involved to the


    Győző Szolnoky

    Chapter 67. The pathophysiology behind adipose tissue deposition in Lymphedema and how

    liposuction completely can reduce the excess volume

    Håkan Brorson

    Chapter 68. Liposuction- can it be implied to the management of Lipedema?

    Robert Damstra & Tobias Bertsch

    Section 15. Management-2 : Lymphangioma

    Chapter 69. How to manage the lymphatic leakage involved in Lymphangioma?

    Xi Yang, Xiaoxi Lin & NingFei Liu,

    Chapter 70. How to manage recurrent infections involved to Lymphangioma?

    Xi Yang, Xiaoxi Lin MD &NingFei Liu

    Chapter 71. How aggressive chyloreflux (e.g. chyluria, chyloascites, chylothorax, chyle-

    leakage) should be handled?

    Miguel Amore & Cristobal Papendieck

    Chapter 72. Pharmacological considerations for Lymphatic Malformation management

    Stanley G. Rockson

    Chapter 73. How much different the management of Lymphangioma among

    pediatric/neonatal age group should be?

    Miguel Amore & Cristobal Papendieck

    Chapter 74. Peculiarities in surgical treatment in childhood; can we ignore?

    Juan Carlos López Gutiérrez

    Part 5. Combined vascular malformations: Hemo-lymphatic

    Malformations / Klippel-Trenaunay Syndrome (KTS)

    Section 16. Diagnosis

    Chapter 75. What extent the diagnostic study should be extended for the Arterio-Venous Malformations involvement to Klippel-Trenaunay Syndrome assessment?

    Massimo Vaghi

    Chapter 76. How much the diagnostic investigations should incorporate visceral

    involvement for Klippel-Trenaunay Syndrome?

    Massimo Vaghi

    Section 17. Management -1

    Chapter 77. How to decide the priority for the treatment among the Congenital Vascular Malformation components?

    James Laredo & BB Lee

    Chapter 78. The management of Vascular Bone Syndrome: how aggressive and when?

    Jong Sup Shim & Young-Wook Kim

    Chapter 79. How aggressive to manage the varicose veins involved to Klippel-Trenaunay Syndrome?

    Sergio Gianesini and Erica Menegatti

    Chapter 80. How aggressive the management of the indolent stasis ulcer should be done

    in Klippel-Trenaunay Syndrome?

    Sergio Gianesini & Erica Menegatti

    Section 18. Management -2

    Chapter 81. How aggressive the gastrointestinal bleeding among Klippel-Trenaunay Syndrome should be handled?

    Massimo Vaghi

    Chapter 82. Therapeutic considerations for infection, sepsis and lymphatic leak management in patients with Klippel-Trenaunay Syndrome

    Jovan Markovic & Cynthia Shortell

    Chapter 83. How to manage the coagulopathy in Klippel-Trenaunay Syndrome?

    Alfonso Tafur, Evi Kalodiki & Jawed Fareed

    Chapter 84. Klippel-Trenaunay Syndrome: Pain and Psychosocial Considerations

    Jamison Harvey, Megha Tollefson, Peter Gloviczki & David Driscoll

    Chapter 85. Klippel-Trenaunay Syndrome and Complex Venous Malformations: Should a multi-modality approach be the standard of care? - Endovenous Laser Ablation (EVLA), Tumescent-assisted Ultrasound-Guided Sclerotherapy (TUGS), n-BCA and Power Phlebectomy.

    Kurosh Parsi & Mina Kang

    Part 6. Capillary Malformations (CMs)

    Section 19. Diagnosis

    Chapter 86. Is this a Capillary Malformation? - Differential diagnosis and other dermal vascular lesions and eruptions.

    Kurosh Parsi & Mina Kang

    Chapter 87. How much the diagnostic assessment for Port Wine Stains should be extended for other Vascular Malformations to exist together?



  • Respiratory Treatment and Prevention
    La comanda in aproximativ 4 saptamani
    78600lei 720.00 lei

    The goal of this book is to further insight into the challenges related to respiratory health. Medical experts present their lines of scientific investigations on how to contain the disease, care for patients, and use preventive measures, with a focus on pulmonary-related disorders. Progress in the diagnostics and treatment of major infectious diseases affecting humanity such as tuberculosis, malaria, fungal and viral contagions is tackled. Other chapters provide some background information on the mechanisms and prevention of non-communicable diseases. New aspects of the etiology of sarcoidosis, air pollution-related lung cancer, and sleep disordered breathing are presented. Preventive measures of health in general and respiratory health in particular cannot do without a reminder of cigarette smoke avoidance and the respiratory aftermath of the smoking habit. The book presents scientific evidence-based practice knowledge. It is intended for healthcare professionals, specifically pulmonary specialists, primary care physicians, and all scientifically-minded individuals involved in the care of patients.

  • 770.00 lei


    Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine

    The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms.

    Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible.

    Essential for practice and education, the landmark 20th Edition features:

                         Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care.

                         State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals.

                         All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine— Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine.

                         Important and timely new chapters—such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more—offer the very latest, definitive perspectives on must-know topics in medical education and practice. 

                         Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes.

                         End-of-chapter suggested readings reinforcement

  • Goldman-Cecil Medicine, 2-Volume Set
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    92900lei 800.00 lei



    To be the best doctor you can be, you need the best information. For more than 90 years, what is now called Goldman-Cecil Medicine has been the authoritative source for internal medicine and the care of adult patients. Every chapter is written by acclaimed experts who, with the oversight of our editors, provide definitive, unbiased advice on the diagnosis and treatment of thousands of common and uncommon conditions, always guided by an understanding of the epidemiology and pathobiology, as well as the latest medical literature.

    But Goldman-Cecil Medicine is not just a textbook. Throughout the lifetime of each edition, periodic updates continually include the newest information from a wide range of journals. Furthermore, Goldman-Cecil Medicine is available for all users of ClinicalKey, Elsevier’s full library of subspecialty textbooks that can be accessed by readers who may want even more in-depth information.

    Table Of Contents:

    1. Approach to Medicine, the Patient, and the Medical Profession: Medicine as a Learned and Humane Profession
    2. Bioethics in the Practice of Medicine
    3. Care of Dying Patients and Their Families
    4. Cultural and Social Disparities in Health Care
    5. Global Health
    6. Approach to the Patient: History and Physical Examination
    7. Approach to the Patient with Abnormal Vital Signs
    8. Statistical Interpretation of Data and Using Data for Clinical Decisions
    9. Measuring Health and Health Care
    10. Quality of Care and Patient Safety
    11. Comprehensive Chronic Disease Management
    12. The Periodic Health Examination
    13. Physical Activity
    14. Adolescent Medicine
    15. Immunization
    16. Principles of Occupational and Environmental Medicine
    17. Radiation Injury
    18. Bioterrorism
    19. Chronic Poisoning: Trace Metals and Others
    20. Epidemiology of Aging: Implications of the Aging of Society
    21. Geriatric Assessment
    22. Common Clinical Sequelae of Aging
    23. Urinary Incontinence
    24. Neuropsychiatric Aspects of Aging
    25. Delirium in the Older Patient
    26. Principles of Drug Therapy
    27. Pain
    28. Biology of Addiction
    29. Nicotine and Tobacco
    30. Alcohol Use Disorders
    31. Drugs of Abuse
    32. Synthetic Immunomodulatory Drug Including Glucocorticoids
    33. Biologic Agents and Signaling Inhibitors
    34. Complementary, Alternative, and Integrative Medicine
    35. Principles of Genetics
    36. Clinical Genomics - Genome Structure and Variation
    37. Applications of Molecular Technologies to Clinical Medicine
    38. Regenerative Medicine, Cell, and Gene Therapies
    39. The Innate Immune System
    40. The Adaptive Immunse System
    41. Mechanisms of Immune-Mediated Tissue Injury
    42. Mechanisms of Inflammation and Tissue Repair
    43. Transplantation Immunology
    44. Complement System in Disease
    45. Approach to the Patient with Possible Cardiovascular Disease
    46. Epidemiology of Cardiovascular Disease
    47. Cardiac and Circulatory Function
    48. Electrocardiography
    49. Echocardiography
    50. Noninvasive Cardiac Imaging
    51. Catheterization and Angiography
    52. Heart Failure: Pathophysiology and Diagnosis
    53. Heart Failure: Management and Prognosis
    54. Diseases of the Myocardium and Endocardium
    55. Principles of Electrophysiology
    56. Approach to the Patient with Suspected Arrhythmia
    57. Approach to Cardiac Arrest and Life-Threatening Arrhythmias
    58. Cardiac Arrhythmias with Supraventricular Origin
    59. Ventricular Arrhythmias
    60. Electrophysiologic Interventional Procedures and Surgery
    61. Congenital Heart Disease in Adults
    62. Angina Pectoris and Stable Ischemic Heart Disease
    63. Acute Coronary Syndrome: Unstable Angina and Non-ST Elevation Myocardial Infarction
    64. ST Elevation Acute Myocardial Infarction and Complications of Myocardial Infarction
    65. Interventional and Surgical Treatment of Coronary Artery Disease
    66. Valvular Heart Disease
    67. Infective Endocarditis
    68. Pericardial Diseases
    69. Diseases of the Aorta
    70. Arterial Hypertension
    71. Atherosclerotic Peripheral Arterial Disease
    72. Other Peripheral Arterial Diseases
    73. Thrombotic Disorders: Hypercoagulable States
    74. Venous Thrombosis and Embolism
    75. Pulmonary Hypertension
    76. Antithrombotic and Antiplatelet Therapy
    77. Approach to the Patient with Respiratory Disease
    78. Imaging in Pulmonary Disease
    79. Respiratory Function and Testing
    80. Disorders of Ventilatory Control
    81. Asthma
    82. Chronic Obstructive Pulmonary Disease
    83. Cystic Fibrosis
    84. Bronchiectasis, Atelectasis, Cysts, and Localized Lung Disorders
    85. Alveolar Filling Disorders
    86. Interstitial Lung Disease
    87. Occupational Lung Disease
    88. Physical and Chemical Injuries of the Lung
    89. Sarcoidosis
    90. Acute Bronchitis and Tracheitis
    91. Overview of Pneumonia
    92. Diseases of the Diaphragm, Chest Wall, Pleura, and Mediastinum
    93. Interventional and Surgical Approaches to Lung Disease
    94. Approach to the Patient in a Critical Care Setting
    95. Respiratory Monitoring in Critical Care
    96. Acute Respiratory Failure
    97. Mechanical Ventilation
    98. Approach to the Patient with Shock
    99. Cardiogenic Shock
    100. Shock Syndromes Related to Sepsis
    101. Disorders Due to Heat and Cold
    102. Acute Poisoning
    103. Medical Aspects of Trauma and Burns
    104. Envenomation, Bites, and Stings
    105. Rhabdomyolysis
    106. Approach to the Patient with Renal Disease
    107. Structure and Function of the Kidneys
    108. Disorders of Sodium and Water Homeostasis
    109. Potassium Disorders
    110. Acid-Base Disorders
    111. Disorders of Magnesium and Phosphorus
    112. Acute Kidney Injury
    113. Glomerular Disorders and Nephrotic Syndromes
    114. Tubulointerstitial Diseases
    115. Diabetes and the Kidney
    116. Vascular Disorders of the Kidney
    117. Nephrolithiasis
    118. Cystic Kidney Diseases
    119. Hereditary Nephropathies and Developmental Abnormalities of the Urinary Tract
    120. Benign Prostatic Hyperplasia and Prostatitis
    121. Chronic Kidney Disease
    122. Treatment of Irreversible Renal Failure
    123. Approach to the Patient with Gastrointestinal Disease
    124. Diagnostic Imaging Procedures in Gastroenterology
    125. Gastrointestinal Endoscopy
    126. Gastrointestinal Hemorrhage
    127. Disorders of Gastrointestinal Motility
    128. Functional Gastrointestinal Disorders: Irritable Bowel Syndrome, Dyspepsia, Esophageal Chest Pain, and Heartburn
    129. Diseases of the Esophagus
    130. Acid Peptic Disease
    131. Approach to the Patient with Diarrhea and Malabsorption
    132. Inflammatory Bowel Disease
    133. Inflammatory and Anatomic Diseases of the Intestine, Peritoneum, Mesentery, and Omentum
    134. Vascular Diseases of the Gastrointestinal Tract
    135. Pancreatitis
    136. Diseases of the Rectum and Anus
    137. Approach to the Patient with Liver Disease
    138. Approach to the Patient with Jaundice or Abnormal Liver Tests
    139. Acute Viral Hepatitis
    140. Chronic Viral and Autoimmune Hepatitis
    141. Toxin- and Drug-Induced Liver Disease
    142. Bacterial, Parasitic, Fungal, and Granulomatous Liver Diseases
    143. Alcoholic and Nonalcoholic Steatohepatitis
    144. Cirrhosis and Its Sequelae
    145. Hepatic Failure and Liver Transplantation
    146. Diseases of the Gallbladder and Bile Ducts
    147. Hematopoiesis and Hematopoietic Growth Factors
    148. The Peripheral Blood Smear
    149. Approach to the Anemias
    150. Microcytic and Hypochromic Anemias
    151. Autoimmune and Intravascular Hemolytic Anemias
    152. Hemolytic Anemias: Red Cell Membrane and Metabolic Defects
    153. The Thalassemias
    154. Sickle Cell Disease and Other Hemoglobinopathies
    155. Megaloblastic Anemias
    156. Aplastic Anemia and Related Bone Marrow Failure States
    157. Polycythemia Vera, Essential Thrombocythemia, and Primary Myelobfibrosis
    158. Leukocytosis and Leukopenia
    159. Approach to the Patient with Lymphadenopathy and Splenomegaly
    160. Histiocytoses
    161. Eosinophilic Syndromes
    162. Approach to the Patient with Bleeding and Thrombosis
    163. Thrombocytopenia
    164. Von Willebrand Disease and Hemorrhagic Abnormalities of Platelet and Vascular Function
    165. Hemorrhagic Disorders: Coagulation Factor Deficiencies
    166. Hemorrhagic Disorders: Disseminated Intravascular Coagulation, Liver Failure, and Vitamin K Deficiency
    167. Transfusion Medicine
    168. Hematopoietic Stem Cell Transplantation
    169. Approach to the Patient with Cancer
    170. Epidemiology of Cancer
    171. Cancer Biology and Genetics
    172. Myelodysplastic Syndromes
    173. The Acute Leukemias
    174. The Chronic Lymphocytic Leukemia
    175. Chronic Myeloid Leukemias
    176. Non-Hodgkin Lymphomas
    177. Hodgkin Lymphoma
    178. Plasma Cell Disorders
    179. Amyloidosis
    180. Tumors of the Central Nervous System
    181. Head and Neck Cancer
    182. Lung Cancer and Other Pulmonary Neoplasms
    183. Neoplasms of the Esophagus and Stomach
    184. Neoplasms of the Small and Large Intestine
    185. Pancreatic Cancer
    186. Liver and Biliary Tract Tumors
    187. Tumors of the Kidney, Bladder, Ureters, and Renal Pelvis
    188. Breast Cancer and Benign Breast Disorders
    189. Gynecologic Cancers
    190. Testicular Cancer
    191. Prostate Cancer
    192. Malignant Tumors of Bone, Sarcomas, and Other Soft Tissue Neoplasms
    193. Melanoma and Nonmelanoma Skin Cancers
    194. Approach to Inborn Errors of Metabolism
    195. Disorders of Lipid Metabolism
    196. Glycogen Storage Diseases
    197. Lysosomal Storage Diseases
    198. Homocystinuria and Hyperhomocysteinemia
    199. The Porphyrias
    200. Wilson’s Disease
    201. Iron Overload (Hemochromatosis)
    202. Nutrition’s Interface with Health and Disease
    203. Protein-Energy Malnutrition
    204. Nutrition in Hospitalized Patients
    205. Vitamins, Trace Minerals, and Other Micronutrients
    206. Eating Disorders
    207. Obesity
    208. Approach to the Patient with Endocrine Disease
    209. Principles of Endocrinology
    210. Neuroendocrinology and the Neuroendocrine System
    211. Anterior Pituitary
    212. Posterior Pituitary
    213. Thyroid
    214. Adrenal Cortex
    215. Adrenal Medulla, Catecholamines, and Pheochromocytoma
    216. Diabetes Mellitus
    217. Hypoglycemia/Pancreatic Islet Cell Disorders
    218. Polyglandular Disorders
    219. Neuroendocrine Tumors
    220. Sexual Development and Identity
    221. The Testis and Male Hypogonadism, Infertility, and Sexual Function
    222. Ovaries and Pubertal Development
    223. Reproductive Endocrinology and Infertility
    224. Approach to Women’s Health
    225. Contraception
    226. Common Medical Problems in Pregnancy
    227. Menopause
    228. Intimate Partner Violence
    229. Approach to the Patient with Metabolic Bone Disease
    230. Osteoporosis
    231. Osteomalacia and Rickets
    232. The Parathyroid Glands, Hypercalcemia, and Hypocalcemia
    233. Paget’s Disease of Bone
    234. Osteonecrosis, Osteosclerosis/Hyperostosis, and Other Disorders of Bone
    235. Approach to the Patient with Allergic or Immunologic Disease
    236. Primary Immunodeficiency Diseases
    237. Urticaria and Angioedema
    238. Systemic Anaphylaxis, Food Allergy, and Insect Sting Allergy
    239. Drug Allergy
    240. Mastocytosis
    241. Approach to the Patient with Rheumatic Disease
    242. Laboratory Testing in the Rheumatic Diseases
    243. Imaging Studies in the Rheumatic Diseases
    244. Inherited Diseases of Connective Tissue
    245. The Systemic Autoinflammatory Diseases
    246. Osteoarthritis
    247. Bursitis, Tendinitis, and Other Periarticular Disorders and Sports Medicine
    248. Rheumatoid Arthritis
    249. The Spondyloarthropathies
    250. Systemic Lupus Erythematosus
    251. Systemic Sclerosis (Scleroderma)
    252. Sjögren’s Syndrome
    253. Inflammatory Myopathies
    254. The Systemic Vasculitides
    255. Giant Cell Arteritis and Polymyalgia Rheumatica
    256. Infections of Bursae, Joints, and Bones
    257. Crystal Deposition Diseases
    258. Fibromyalgia, Chronic Fatigue Syndrome, and Myofascial Pain
    259. Systemic Diseases in Which Arthritis Is a Feature
    260. Surgical Treatment of Joint Diseases
    261. Introduction to Microbial Disease: Pathophysiology and Diagnostics
    262. The Human Microbiome
    263. Principles of Anti-Infective Therapy
    264. Approach to Fever or Suspected Infection in the Normal Host
    265. Approach to Fever and Suspected Infection in the Compromised Host
    266. Prevention and Control of Health Care-Associated Infections
    267. Approach to the Patient with Suspected Enteric Infection
    268. Approach to the Patient with Urinary Tract Infection
    269. Approach to the Patient with a Sexually Transmitted Infection
    270. Approach to the Patient before and after Travel
    271. Antibacterial Chemotherapy
    272. Staphylococcal Infections
    273. Streptococcus Pneumoniae Infections
    274. Nonpneumococcal Streptococcal Infections and Rheumatic Fever
    275. Enterococcal Infections
    276. Diphtheria and Other Corynebacteria Infections
    277. Listeriosis
    278. Anthrax
    279. Erysipelothrix Infections
    280. Clostridial Infections
    281. Diseases Caused by Non-Spore-Forming Anaerobic Bacteria
    282. Neisseria Meningitidis Infections
    283. Neisseria Gonorrhoeae Infections
    284. Haemophilus and Moraxella Infections
    285. Chancroid
    286. Cholera and Other Vibrio Infections
    287. Campylobacter Infections
    288. Escherichia Coli Enteric Infections
    289. Infections due to Other Members of the Enterobacteriaceae, including Management of Multidrug Resistant Strains
    290. Pseudomonas and Related Gram-Negative Bacillary Infections
    291. Diseases Caused by Acinetobacter and Stenotrophomonas Species
    292. Salmonella Infections (including Typhoid Fever)
    293. Shigellosis
    294. Brucellosis
    295. Tularemia and Other Francisella Infections
    296. Plague and Other Yersinia Infections
    297. Whooping Cough and Other Bordetella Infections
    298. Legionella Infections
    299. Bartonella Infections
    300. Granuloma Inguinale (Donovanosis)
    301. Mycoplasma Infections
    302. Diseases Caused by Chlamydiae
    303. Syphilis
    304. Nonsyphilitic Treponematoses
    305. Lyme Disease
    306. Relapsing Fever and Other Borrelia Infections
    307. Leptospirosis
    308. Tuberculosis
    309. The Nontuberculous Mycobacteria
    310. Leprosy (Hansen Disease)
    311. Rickettsial Infections
    312. Zoonoses
    313. Actinomycosis
    314. Nocardiosis
    315. Systemic Antifungal Agents
    316. Endemic Mycoses
    317. Cryptococcosis
    318. Candidiasis
    319. Aspergillosis
    320. Mucormycosis
    321. Pneumocystis Pneumonia
    322. Mycetoma and Dematiaceous Fungal Infections
    323. Antiparasitic Therapy
    324. Malaria
    325. African Sleeping Sickness
    326. Chagas Disease
    327. Leishmaniasis
    328. Toxoplasmosis
    329. Cryptosporidiosis
    330. Giardiasis
    331. Amebiasis
    332. Babesiosis and Other Protozoan Diseases
    333. Cestodes
    334. Trematode Infections
    335. Nematode Infections
    336. Antiviral Therapy (Non-HIV)
    337. The Common Cold
    338. Respiratory Syncytial Virus
    339. Parainfluenza Viral Disease
    340. Influenza
    341. Adenovirus Diseases
    342. Coronaviruses
    343. Measles
    344. Rubella (German Measles)
    345. Mumps
    346. Cytomegalovirus, Epstein-Barr Virus, and Slow Virus Infections of the Central Nervous System
    347. Parvovirus
    348. Smallpox, Monkeypox, and Other Poxvirus Infections
    349. Papillomavirus
    350. Herpes Simplex Virus Infections
    351. Varicella-Zoster Virus (Chickenpox, Shingles)
    352. Cytomegalovirus
    353. Epstein-Barr Virus Infection
    354. Retroviruses Other Than Human Immunodeficiency Virus
    355. Enteroviruses
    356. Rotaviruses, Noroviruses, and Other Gastrointestinal Viruses
    357. Viral Hemorrhagic Fevers
    358. Arboviruses Causing Fever and Rash Syndromes
    359. Arboviruses Affecting the Central Nervous System
    360. Epidemiology of Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome
    361. Immunopathogenesis of Human Immunodeficiency Virus Infection
    362. Biology of Human Immunodeficiency Viruses
    363. Prevention of Human Immunodeficiency Virus Infection
    364. Antiretroviral Therapy of HIV/AIDS
    366. Systemic Manifestations of HIV/AIDS
    367. Immune Reconstitution Inflammatory Syndrome in HIV/AIDS
    368. Approach to the Patient with Neurologic Disease
    369. Psychiatric Disorders in Medical Practice
    370. Headaches and Other Head Pain
    371. Traumatic Brain Injury and Spinal Cord Injury
    372. Mechanical and Other Lesions of the Spine, Nerve Roots, and Spinal Cord
    373. Regional Cerebral Dysfunction: Higher Mental Functions
    374. Cognitive Impairment and Dementia
    375. The Epilepsies
    376. Coma, Vegetative State, and Brain Death
    377. Sleep Disorders
    378. Approach to Cerebrovascular Diseases
    379. Ischemic Cerebrovascular Disease
    380. Hemorrhagic Cerebrovascular Disease
    381. Parkinsonism
    382. Other Movement Disorders
    383. Multiple Sclerosis and Demyelinating Conditions of the Central Nervous System
    384. Meningitis: Bacterial, Viral, and Other
    385. Brain Abscess and Parameningeal Infections
    386. Acute Viral Encephalitis
    387. Prion Diseases
    388. Nutritional and Alcohol-Related Neurologic Disorders
    389. Congenital, Developmental, and Neurocutaneous Disorders
    390. Autonomic Disorders and Their Management
    391. Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases
    392. Peripheral Neuropathies
    393. Muscle Diseases
    394. Disorders of Neuromuscular Transmission
    395. Diseases of the Visual System
    396. Neuro-Ophthalmology
    397. Diseases of the Mouth and Salivary Glands
    398. Approach to the Patient with Nose, Sinus, and Ear Disorders
    399. Smell and Taste
    400. Hearing and Equilibrium
    401. Throat Disorders
    402. Principles of Medical Consultation
    403. Preoperative Evaluation
    404. Overview of Anesthesia
    405. Postoperative Care and Complications
    406. Medical Consultation in Psychiatry
    407. Approach to Skin Diseases
    408. Principles of Therapy of Skin Diseases
    409. Eczema, Photodermatoses, Papulosquamous (including Fungal) Diseases, and Figurate Erythemas
    410. Macular, Papular, Vesiculobullous, and Pustular Diseases
    411. Urticaria, Drug Hypersensitivity Rashes, Nodules and Tumors, and Atrophic Diseases
    412. Infections, Hyperpigmentation and Hypopigmentation, Regional Dermatology, and Distinctive Lesions in Black Skin
    413. Diseases of Hair and Nails




  • Microvascular Disease in Diabetes
    La comanda in aproximativ 4 saptamani
    87000lei 800.00 lei


    Presents comprehensive coverage of the many microvascular complications of diabetes

    Diabetes remains one of the main causes, in the western world, of legal blindness, end stage renal disease, and amputation, despite the implementation of tight glycemic control and the great progress in the management and care of our patients. This book provides a useful and handy tool to professionals and students in the field of diabetes and its microvascular complications by integrating information from clinical settings as well as from the frontlines of diabetic research. It provides readers with up-to-date diagnostic criteria, classifications, and therapeutic approaches. and recent discoveries on mechanisms of disease, experimental therapeutic agents, and biomarkers of disease. 

    Written by top experts in the field, Microvascular Disease in Diabetes offers in-depth chapters covering pathophysiology; the genetics of diabetic microvascular disease; and the epigenetics of diabetic microvascular disease. It then provides sections featuring both clinical and research information on diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, and diabetic foot. It also looks at coronary microvascular dysfunction and cerebral microvascular disease.

    ·         Integrates new and accessible material on diabetic microvascular comorbidities

    ·         Covers all relevant microvascular systems

    ·         Provides a much-needed resource synthesizing research and clinical applications to treating microvascular complications of diabetes

    ·         Presents current diagnostic criteria, classifications, and therapeutic approaches, as well as recent discoveries on the mechanisms of disease, experimental therapeutic agents, and biomarkers of disease

    Assembled in an easily consultable manner, Microvascular Disease in Diabetes is an excellent text for investigators, clinicians, and students looking to improve their understanding of diabetic complications.


    FRANCESCO TECILAZICH, MD, PhD, is a physician and scientist in the Endocrinology and Metabolic Diseases department of the Ospedale San Raffaele—Vita Salute San Raffaele University in Milan, Italy.


    Foreword to: Microvascular Disease in Diabetes xv

    Editor Biography xvii

    List of Contributors xix

    1 Introduction 1
    Andrea Giustina and Stefano Frara

    References 3

    2 Pathophysiology 5
    Francesco Tecilazich

    Introduction 5

    Anatomo-Physiology of Microvessels 5

    Regulation of Microvascular Tone 6

    Endothelial-Dependent Vasodilation 6

    Endothelial-Independent Vasodilation 6

    Nerve Axon Reflex (NARV) 7

    Myogenic Response 7

    Functional Hyperemia 7

    Venoarteriolar Response (VAR) 8

    Structural Changes in the Microcirculation 8

    Functional Changes in the Microcirculation 8

    Endothelial Dysfunction 8

    VSMC Dysfunction 9

    NARV Impairment 9

    Defective Myogenic Response 10

    Reduced Functional Hyperemia 10

    Endothelial Dysfunction 11

    Role of the Immune System and Leukostasis 11

    Role of Hyperglycemia 12

    AGEs 12

    Polyol Pathway 12

    Oxidative Stress 13

    PKC 13

    Transforming Growth Factor (TGF)-β 14

    Hexosamine Pathway 14

    PARP 14

    ET-1 14

    Vasoconstrictor Prostanoid Synthesis 15

    Role of Insulin Resistance 15

    Role of Inflammation 15

    References 16

    3 Genetics of Diabetic Microvascular Disease 23
    Niina Sandholm and Carol Forsblom

    Introduction 23

    Genetics of DKD 23

    Heritability of DKD 23

    Candidate Genes for DKD 24

    Linkage Studies for DKD 25

    Genome-Wide Association Studies on DKD 25

    Sequencing Efforts for DKD 29

    Genetics of Diabetic Retinopathy 30

    Heritability of Diabetic Retinopathy 30

    Candidate Genes for Diabetic Retinopathy 30

    Linkage Studies for Diabetic Retinopathy 31

    GWAS on Diabetic Retinopathy 31

    Sequencing Efforts for Diabetic Retinopathy 33

    Genetics of Diabetic Neuropathy 33

    Heritability of Diabetic Neuropathy 33

    Candidate Genes for Diabetic Neuropathy 33

    GWASs on Diabetic Neuropathy 34

    Future Directions 34

    Larger Studies are Needed 34

    How to Define the Phenotype? 35

    Variability in the Phenotypic Definitions 35

    Criteria for Controls 36

    Do Genetics of Microvascular Complications in T1D and T2D Differ? 36

    Low-Frequency and Rare Variants May Affect Diabetic Complications 36

    Sequencing of Rare and Low-Frequency Variants 36

    Linkage Analysis with GWAS Data 37

    Genetics May Reveal Biology and Infer Causality 37

    Conclusions 37

    References 37

    4 Epigenetics of Diabetic Microvascular Disease 45
    Luciano Pirola

    Diabetic Complications Include Microvascular and Macrovascular Injury 45

    The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study in Type 1 Diabetic Patients, and the UKPDS Study in Type 2 Diabetic Patients, Support the Existence of the Hyperglycemic Memory Phenomenon 46

    DCCT/EDIC Study 46

    The UKPDS Study 46

    Models of Hyperglycemic Memory 47

    Animal Models 47

    Cell Culture Models 48

    The “Epigenetic Code” 48

    DNA Methylation 49

    Histone Methylation in Models of Hyperglycemic Variability 49

    Epigenetic Changes in Microvascular Models of Glycemic Memory 50

    MiRNAs Contribute to the Control of Glucose Homeostasis and are Dysregulated in Diabetes 52

    Future Prospects 52

    References 54

    5 Diabetic Retinopathy – Clinical 59
    Francesco Bandello, Rosangela Lattanzio, Alessandro Marchese, and Emanuela Aragona

    Introduction 59

    Epidemiology 60

    Screening 60

    Risk Factors 61

    Clinical Patterns 61

    Non-Proliferative Diabetic Retinopathy (NPDR) 61

    Clinical Findings 62

    Diagnostic Tools 64

    Treatment Strategies 65

    Proliferative Diabetic Retinopathy (PDR) 65

    Clinical Findings 65

    Diagnostic Tools 67

    Treatment Strategies 67

    Diabetic Macular Edema (DME) 69

    Classification 70

    Clinical Findings 71

    Diagnostic Tools 71

    Treatment Strategies 71

    Conclusions 73

    References 74

    6 Diabetic Retinopathy – Research 79
    Gopalan Gnanaguru

    Retina and Induction of Hyperglycemia 79

    Hyperglycemia and Retinal Microvasculature 80

    Hyperglycemia and Reactive Gliosis 80

    Hyperglycemia and Neurodegeneration 81

    Hyperglycemia and Inflammation 81

    References 82

    7 Diabetic Nephropathy – Clinical 85
    Gianpaolo Zerbini

    Epidemiology 85

    Natural History 86

    Stages of DN 86

    Morphologic Changes 87

    Pathophysiology 88

    Clinical Course 89

    Treatment 90

    Primary Prevention 90

    Secondary Prevention 91

    Tertiary Prevention 91

    Perspectives 91

    References 92

    8 Diabetic Nephropathy – Research 97
    Silvia Maestroni and Gianpaolo Zerbini

    Essential Hypertension and DN 97

    Role of Genetics in the Pathogenesis of DN 99

    Polyol Pathway and Non-Enzymatic Glycation 100

    Environment 100

    Perspectives 101

    Sodium–Glucose Cotransporter-2 (SGLT2) and DN 101

    B7-1 and DN 101

    Animal Models 102

    DN in Induced Model of Type 1 Diabetes Mellitus (T1DM) 102

    DN in Spontaneous Model of T1DM 103

    Ins2Akita Mice 103

    Non-Obese Diabetic (NOD) Mice 104

    OVE26 Friend leukemia virus B (FVB) Mice 104

    DN in Spontaneous Models of T2DM 105

    db/db Mice 105

    References 105

    9 Diabetic Neuropathy – Clinical 111
    Christopher H. Gibbons

    Introduction 111

    Classification of Diabetic Neuropathies 111

    Distal Symmetric Polyneuropathy (DSPN) 112

    Diagnosis 113

    Management 113

    Small Fiber Neuropathy 114

    Diagnosis 115

    Management 115

    Autonomic Neuropathy 116

    Diagnosis 117

    Management 117

    Treatment-Induced Neuropathy of Diabetes (TIND) 119

    Diagnosis 119

    Management 120

    Diabetic Radiculoplexopathy 120

    Diagnosis 120

    Management 121

    Mononeuropathies 121

    Diagnosis 121

    Management 121

    Cranial Neuropathies 121

    Diagnosis 121

    Management 122

    Screening for Neuropathy 122

    Summary of Management of Diabetic Neuropathy 122

    References 123

    10 Diabetic Neuropathy – Research 129
    Krish Chandrasekaran, Lindsay A. Zilliox, and James W. Russell

    Basic and Translational Research in Diabetic Neuropathy 129

    Animal Models of Diabetic Neuropathy 129

    Basic Pathophysiology of Diabetic Neuropathy 131

    Changes in Redox Potential 131

    Role of Mitochondrial Dysfunction in Diabetic Neuropathy 133

    Protein Kinase C (PKC) and Neuropathy 137

    Advanced Glycation End Products 137

    Modifying Molecular Chaperones 138

    Inflammation and Neuropathy 138

    TGF-β and Neuropathy 138

    Metabotropic Glutamate Receptors (mGluRs) and Oxidative Injury 139

    Growth Factors and Diabetes 139

    Clinical Research in Diabetic Neuropathy 140

    Treatment of Hypertension 141

    Improved Glycemic Control 141

    Diet and Lifestyle Interventions 142

    Alpha-Lipoic Acid 144

    Benfotiamine and Neuropathy 145

    Treatment of Neuropathic Pain 145

    Acknowledgments 146

    References 147

    11 Diabetic Foot – Clinical 157
    Cristian Nicoletti

    Introduction and Size of the Problem 157

    Pathogenesis of Diabetic Foot Complications 158

    Neuropathy 158

    Peripheral Vascular Disease 158

    Other Risk Factors 159

    Prevention 159

    Treatment 160

    Treatment of Neuropathic Diabetic Foot Ulcers: Offloading 160

    Treatment of PAD: Revascularization 161

    Diabetic Foot Infections (DFIs) 163

    Introduction 163

    Diagnosis 163

    Treatment 164

    Wound Healing 166

    Debridement 166

    Dressings 167

    Topical Negative Pressure Wound Therapy (NPWT) 167

    Other Topical Treatments 167

    References 167

    12 Diabetic Foot – Research 173
    Georgios Theocharidis and Aristidis Veves

    Introduction 173

    Anatomy of the Skin and Microcirculation 174

    Structural Changes in the Microcirculation 174

    Functional Changes in the Microcirculation 175

    Functional Changes in the Diabetic Foot 176

    Vasodilation 176

    Endothelium-Dependent Vasodilation 177

    Endothelium-Independent Vasodilation 178

    Nerve Axon Reflex 179

    Mechanisms of Endothelial Dysfunction 180

    Endothelial Dysfunction and Hyperglycemia 180

    Endothelial Dysfunction and Insulin Resistance 182

    Endothelial Dysfunction and Inflammation 183

    Pathophysiology of Diabetic Wound Healing 184

    Hyperglycemia 184

    Chronic Inflammation 184

    Impaired Angiogenesis and Vasculogenesis 186

    Hypoxia 186

    Impaired Neuropeptide Signaling 186

    Adjunctive Treatment Options 186

    Bioengineered Skin Substitutes 187

    Growth Factors 187

    Hyperbaric Oxygen Therapy 188

    Negative Pressure Wound Therapy 188

    Electrical Stimulation and Shockwave Therapy 189

    Future Therapeutic Perspectives 189

    Gene Therapies 189

    Stem Cell Therapies 189

    Norleu3-Angiotensin-(1–7) 190

    Neuropeptides 190

    Cytokine Inhibition 190

    Conclusion 191

    References 191

    13 Coronary Microvascular Dysfunction in Diabetes – Clinical and Research 201
    Guglielmo Gallone, Francesco Moroni, and Marco Magnoni

    Introduction 201

    Clinical Classification and Mechanisms of CMD 202

    CMD in Diabetic Patients 203

    Clinical Assessment of CMD 205

    Non-Invasive Imaging Technique for the Assessment of CMD 205

    Transthoracic Doppler Evaluation 205

    Contrast Echocardiography 206

    Cardiovascular Magnetic Resonance (CMR) Imaging 206

    Positron Emission Tomography (PET) 207

    Invasive Techniques for the Evaluation of CBF 207

    Indicator Dilution-Based Methods 207

    Thermodilution 208

    Gas Wash Out Method 208

    Intracoronary Doppler Flow Wire 208

    Treatment for CMD 210

    The Effects of Glucose-Lowering Drugs on CMD 211

    Future Perspectives for the Treatment of CMD in Diabetes 211

    References 212

    14 Cerebral Microvascular Disease in Diabetes – Clinical and Research 221
    Eelco van Duinkerken and Richard G. IJzerman

    Introduction 221

    Postmortem Studies of the Brain in Diabetes 222

    Cerebral Small Vessel Disease on MRI 223

    MRI-Measured Cerebral Small Vessel Disease in Type 1 Diabetic Patients 224

    White Matter Hyperintensities 224

    Cerebral Microbleeds 226

    Summary 226

    Type 2 Diabetes and Cerebral Small Vessel Disease 227

    Lacunar Infarcts 227

    White Matter Hyperintensities 228

    Cerebral Microbleeds 230

    Synthesis 230

    Clinical Impact of Cerebral Small Vessel Disease in Diabetes 231

    Cognitive Functioning 231

    Stroke 233

    Dementia 234

    The Influence of Microvascular Disease on the Structure and Functioning of the Diabetic Brain 235

    Type 1 Diabetes 236

    Type 2 Diabetes 237

    Conclusions and Future Directions 239

    References 240

    Index 247



  • 94500lei 800.00 lei



    A valuable new reference in the diagnosis and image-guided treatment of congenital heart defects

    Congenital heart defects represent the most common birth defect and affect millions of children worldwide.

    Defects of the heart and great vessels span a broad spectrum. Modern medical progress has enabled more than 90% of patients to reach adulthood. In many cases, however, patients remain ill throughout their lives, with significant limits on quality of life and physical capacity. Our ongoing goals are to improve treatment options even further.

    This book details all important imaging techniques for diagnosing congenital heart defects and assessing their severity. The author is a highly experienced expert in his field, making his clinical experience available to readers who can then implement that knowledge in their own daily routine.

    Key Features:

    ·         All key imaging modalities, including 2D and 3D echocardiography, cardiac catheter exams, MRI and MR angiography, CT, and chest X-ray

    ·         Descriptions of general and technical fundamentals, a structure based on clinical pictures, and current standard values

    ·         Crucial information emphasized in callout boxes and tabular overviews

    ·         Supports the professional dialogue between all the involved caretakers

    ·         Richly illustrated with more than 1,000 stunning images from the newest generation of devices

    Gutberlet's Diagnostic Imaging of Congenital Heart Defects: Diagnosis and Image-Guided Treatment will be welcomed by pediatric and general radiologists as a comprehensive, multimodality guide to the diagnosis and management of congenital heart defects.

    This book includes complimentary access to a digital copy on

    Table of Contents:


    1 Cardiogenesis and Classification of Congenital Heart Defects

    2 Surgical Treatment for Congenital Heart Defects

    3 Technical Basics of Diagnostic and Interventional Imaging

    4 Clinical Pictures

    5 Standard Values and Formulas



  • 815.00 lei


    State-of-the-art resource details effective breast MRI techniques for improved screening and diagnosis

    Magnetic resonance imaging (MRI) of the breast has evolved into an important breast cancer screening tool and major advance in women's health. Breast MRI is currently the most sensitive detection technique for both non-invasive and invasive cancers and follow-up in women with a new breast cancer diagnosis. It is increasingly becoming the go-to imaging method for screening women at high and intermediate risk of breast cancer and those with dense breast tissue on mammography. Yet despite its reliability and growing use, many radiologists lack the expertise to accurately perform breast MR image interpretation.

    Breast MRI Interpretation: Text and Online Case Analysis for Screening and Diagnosis by Gillian Newstead reflects insights and expertise from one of the leading authorities on breast imaging. The book is a highly practical reference on evaluation and interpretation of breast MR imaging, with discussion of the modality as a screening and diagnostic tool. Topics include image acquisition and interpretation, clinical implementation, managing findings, and overcoming problems.


    Key Highlights

    ·         More than 1,800 illustrations from the University of Chicago including single selected images, side-by-side images at different time points and acquisition parameters, and 3-D images enhance understanding of breast imaging

    ·         Select online case studies enable readers to review and interpret entire MRI datasets

    ·         Discussion of advanced acquisition techniques and future potential applications including non-contrast imaging, quantitative dynamic imaging, and artificial intelligence using advanced computer analytic methods

    This remarkable resource streamlines the breast MRI process, enabling radiologists to incorporate this imaging modality into practice, conduct screening and diagnostic exams more efficaciously, and interpret findings accurately.


  • 870.00 lei



    The seventh edition of the most authoritative and comprehensive book published on lung function, now completely revised and restructured

    A practical guide to autoimmune liver diseases through pathogenesis, diagnosis, and management

    In Autoimmune Liver Disease Management and Clinical Practice, practitioners will learn about the current state of autoimmune liver disease and how to focus on their diagnosis and treatment. The four-part book begins with a thorough investigation of current immunological thinking as it relates to the autoimmunity of the liver. It also covers the four major hepatic autoimmune liver diseases in both adults and children, their management and the role of liver transplantation, and learned approaches to patient management and empowerment.

    Expert authors in the field have come together to provide a thorough examination of autoimmune liver disease to help support clinicians assisting patients. The text provides an in-depth look at topics including:

    ●      The four major hepatic autoimmune liver diseases, their diagnosis, and potential disease management

    ●      The use (and misuse) of autoantibodies in diagnosis and treatment

    ●      The role and timing of liver transplantation and the impact of recurrent autoimmune liver disease as well as de novo autoimmune hepatitis

    ●      Optimal approaches to managing patients and keeping care personalised

    With breadth, depth and current-day relevance, Autoimmune Liver Disease sheds light on recent developments in management of liver disease for practitioners, nurses, and health care professionals.


    John Cotes, PhD, (deceased), was a respiratory physiologist who played a key role in the conquest of Everest in 1953. He also played prominent roles in the European Respiratory Society, the Thoracic Society, and the Association of Respiratory Technicians and Physiologists, and was an honorary fellow of the Faculty of Occupational Medicine.

    Robert L. Maynard, CBE, FRCP, FRCPath, is an Honorary Professor of Environmental Medicine at the University of Birmingham, Birmingham, UK.

    Sarah J. Pearce, FRCP, is Formerly Consultant Physician at County Durham and Darlington NHS Foundation Trust, Darlington, UK.

    Benoit B. Nemery, MD, PhD, is Professor of Toxicology & Occupational Medicine for the Faculty of Medicine at the Department of Public Health and Primary Care, KU Leuven, Belgium.

    Peter D. Wagner, MD, is Distinguished Professor of Medicine & Bioengineering at the University of California, San Diego, CA, USA.

    Brendan G. Cooper, PhD, FERS, FRSB, is Consultant Clinical Scientist in Respiratory and Sleep Physiology at University Hospital Birmingham and holds an Honorary Professorship in Respiratory & Sleep Physiology at the University of Birmingham, Birmingham, UK.



    Preface xxvii

    Contributors xxix

    Part I Introduction 1

    1 How We Came to Have Lungs and How Our Understanding of Lung Function has Developed 3

    Part II Foundations 21

    2 Getting Started 23

    3 Development and Functional Anatomy of the Respiratory System 33
    Sungmi Jung and Richard Fraser

    4 Body Size and Anthropometric Measurements 45

    5 Numerical Interpretation of Physiological Variables 57
    J. Martin Bland

    6 Basic Terminology and Gas Laws 75
    Adrian Kendrick

    7 Basic Equipment and Measurement Techniques 91
    Brendan G. Cooper

    8 Respiratory Surveys 117
    Peter G.J. Burney

    9 The Application of Analytical Technique Applied to Expired Air as a Means of Monitoring Airway and Lung Function 129
    Paolo Paredi and Peter Barnes

    Part III Physiology and Measurement of Lung Function 149

    10 Chest Wall and Respiratory Muscles 151
    Andre De Troyer and John Moxham

    11 Lung Volumes 177

    12 Lung and Chest Wall Elasticity 187
    G. John Gibson

    13 Forced Ventilatory Volumes and Flows 203
    Riccardo Pellegrino

    14 Theory and Measurement of Respiratory Resistance 217
    Jason H.T. Bates

    15 The Control of Airway Function and the Assessment of Airway Calibre 231
    Eric Derom

    16 Ventilation, Blood Flow, and Their InterRelationships 259
    G. Kim Prisk

    17 Transfer of Gases into the Blood of Alveolar Capillaries 301
    Eric Derom and Guy F. Joos

    18 Transfer Factor (Tl) for carbon monoxide (CO) and nitric oxide (NO) 313
    Colin D.R. Borland and Mike Hughes

    19 Oxygen 353
    Dan S. Karbing and Stephen E. Rees

    20 Carbon Dioxide 377
    Erik R. Swenson

    21 Control of Respiration 389
    Bertien M.
    A. Buyse

    22 The Sensation of Breathing 407
    Mathias Schroijen, Paul W. Davenport, Omer Van den Bergh, and Ilse Van Diest

    23 Breathing Function in Newborn Babies 423
    Urs P. Frey and Philipp Latzin

    Part IV Normal Variation in Lung Function 435

    24 Normal Lung Function from Childhood to Old Age 437
    Andrew Bush and Michael D.L. Morgan

    25 Reference Values for Lung Function in White Children and Adults 463

    26 Reference Values for Lung Function in NonWhite Adults and Children 499

    Part V Exercise 517

    27 Physiology of Exercise and Effects of Lung Disease on Performance 519

    28 Exercise Testing and Interpretation, Including Reference Values 553

    29 Assessment of Exercise Limitation, Disability, and Residual Ability 577

    30 Exercise in Children 587
    Andrew Bush

    Part VI Breathing During Sleep 595

    31 Breathing During Sleep and its Investigation 597
    Joerg Steier

    Part VII Potentially Adverse Environments 615

    32 Hypobaria 617
    James Milledge

    33 Immersion in Water, Hyperbaria, and Hyperoxia Including Oxygen Therapy 639
    Einar Thorsen

    34 Effects of Cold and Heat on the Lung 653
    Malcolm Sue

    Part VIII Lung Function in Clinical Practice 661

    35 Strategies for Assessment of Lung Function 663
    James Hull

    36 Patterns of Abnormal Lung Function in Lung Disease 673
    William Kinnear

    37 Lung Function in Asthma, Chronic Obstructive Pulmonary Disease, and Lung Fibrosis 681
    Wim Janssens and Pascal Van Bleyenbergh

    38 Lung Function in Specific Respiratory and Systemic Diseases 697
    Stephen J. Bourke

    39 Pulmonary Rehabilitation 729
    Sally Singh

    40 Lung Function in Relation to Surgery, Anaesthesia, and Intensive Care 737
    Goran Hedenstierna

    Index 751


  • 1,01000lei 910.00 lei

    This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field.

    Written by experts in their field, Crohn’s Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis, and related autoimmune disorders.

  • 1,18300lei 1000.00 lei

    Improvements in the detection of fetal and neonatal brain injuries, advances in our understanding of the pathophysiology, cellular and molecular bases of encephalopathy, and new treatment options have all combined to produce significant changes in the management of neonatal brain disorders in the past few years. This new edition of Fetal and Neonatal Brain Injury brings the reader fully up to date with all advances in clinical management and outcome assessment. Updated material includes inflammation focusing in particular on chorioamnionitis and fetal brain injury; genetic brain injury; and expanded sections on cholestasis, diabetes, and thyroid disease. An updated, highly illustrated chapter on structural and functional imaging of the fetal and neonatal brain is also included. An outstanding international team of highly experienced neonatologists and maternal-fetal medicine clinicians have produced a practical, authoritative clinical text that gives clear management advice to all clinicians involved in the treatment of these patients.

  • Hagberg and Benumof's Airway Management
    La comanda in aproximativ 4 saptamani
    1,14000lei 1030.00 lei


    Anesthesiologists, residents, and advanced practice practitioners alike rely upon the comprehensive content of Hagberg and Benumof’s Airway Management to remain proficient in this essential area. The 4th Edition, by Drs. Carin A. Hagberg, Carlos A. Artime, and Michael F. Aziz, continues the tradition of excellence with coverage of new devices and algorithms, new research, new outcomes reporting, and much more - while retaining a concise, how-to approach; carefully chosen illustrations; and case examples and analysis throughout.


    Offers expert, full-color guidance on pre- and post-intubation techniques and protocols, from equipment selection through management of complications.

    Includes access to more than 25 videos online, including ultrasonography and non-invasive airway management and flexible scope intubation.

    New To This Edition:

    Includes the latest ASA guidelines, as well as six all-new chapters including airway management in nonoperating room locations (NORA), airway management and outcomes reporting, and more.

    Features completely rewritten chapters on airway pharmacology, algorithms for management of the difficult airway, airway assessment, video-assisted laryngoscopy, and many more.

    Reviews new airway devices and techniques, along with indications for and confirmation of tracheal intubation.

    Brings you up to date with the latest devices, the DAS extubation algorithm, the Vortex approach, and emergency cricothyrotomy.

    Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

    Table Of Contents:

    Hagberg and Benumof's Airway Management, 4e



    PART 1 Basic Clinical Science Considerations

    1. Functional anatomy of the airway

    2. Radiographic and cross-sectional imaging of the airway

    3. Ultrasonography in airway management

    4. Physics of the airway

    5. Physiology of the airway

    6. Airway pharmacology

    7. Physiologic and pathophysiologic responses to intubation

    PART 2 The Difficult Airway: Definition, Recognition, and the ASA Algorithm

    8. Definition and incidence of the difficult airway

    9. Airway assessment and prediction of the difficult airway

    10. Development of an airway management plan

    11. Algorithms for management of the difficult airway

    PART 3 Preintubation-Ventilation Procedures

    12. Preparation of the patient for awake intubation

    13. Aspiration prevention and prophylaxis: preoperative considerations for the full stomach patient

    14. Preoxygenation

    15. Techniques to Induce General Anesthesia

    PART 4 The Airway Techniques

    16. History of airway management

    17. Oxygen delivery systems, inhalation and respiratory therapy

    18. Noninvasive management of the airway

    19. Supraglottic airway techniques: Laryngeal mask airways

    20. Supraglottic airway techniques: Nonlaryngeal mask airways

    21. Laryngoscopic tracheal intubation

    22. Blind intubation techniques

    23. Intubating introducers, lighted and optical stylets

    24. Video-assisted laryngoscopy

    25. Flexible scope intubation techniques

    26. Lung isolation techniques

    27. Percutaneous emergency airway access

    28. Rigid bronchoscopy

    29. Surgical airway

    30. Confirmation of tracheal intubation

    PART 5 Difficult Airway Situations

    31. Prehospital airway management

    32. Cardiopulmonary resuscitation and airway management

    33. Austere environment and disaster preparedness

    34. Airway Management in the Trauma Patient

    35. Airway management in burn patients

    36. Airway management in pediatric patients

    37. Airway management in obstetric patients

    38. Airway management in head and neck surgery

    39. Anesthesia for laser airway surgery

    40. Airway management in neurosurgical patients

    41. Obesity, Sleep Apnea, the Airway, and Anesthesia

    42. Regional anesthesia and the difficult airway

    43. Airway management in nonoperating room locations

    44. Airway management in intensive care medicine

    PART 6 Postintubation Procedures

    45. Endotracheal tube and respiratory care

    46. Mechanical ventilation 47. Monitoring the airway and pulmonary function

    48. Extubation and reintubation of the difficult airway

    49. Complications of managing the airway

    PART 7 Societal Considerations

    50. Airway management education

    51. Dissemination of critical airway information

    52. Airway Research

    53. Airway management and outcomes reporting

    54. Role of the airway community




  • 1100.00 lei



    Clinical Small Animal Internal Medicine is a comprehensive, practical reference designed to meet the needs of veterinary practitioners and students alike. Covering all aspects of small animal internal medicine, this innovative guide provides clinically relevant material, plus podcasts and continual updates online. Concise, identically-formatted chapters allow readers to quickly find the most essential information for clinical veterinary practice. 

    Contributions from academic and clinical experts cover general medicine subjects, including patient evaluation and management, critical care medicine, preventative care, and diagnostic and therapeutic considerations. Topics relevant to daily clinical practice are examined in detail, ranging from endocrine, cardiovascular, respiratory, and infectious disease to oncology, dermatology, metabolic orthopedic disease, gastroenterology, and hepatology. A companion website features podcasts and updated information. An important addition to the library of any practice, this clinically-oriented text: 

    ·         Presents complete, practical information on small animal internal medicine

    ·         Provides the background physiology required to understand normal versus abnormal in real-world clinical settings

    ·         Includes general medicine topics not covered in other internal medicine books

    ·         Focuses on information that is directly applicable to daily practice

    ·         Features podcasts and continual updates on a companion website 

    Carefully tailored for the needs of small animal practitioners and veterinary students, Clinical Small Animal Internal Medicine is an invaluable, reader-friendly reference on internal medicine of the dog and cat. 




    List of Contributors

    About the Companion Website

    Volume I

    Section 1 Evaluation and Management of the Patient

    1 The Concept of One Medicine
    Lonnie J. King

    2 Statistical Interpretation for Practitioners
    Philip H. Kass

    3 Using Data For Clinical Decision Making
    Philip H. Kass

    Section 2 Endocrine Disease

    4 Principles of Endocrinology
    Robert Kemppainen

    5 Neuroendocrinology
    Maya Lottati

    6 Feline Acromegaly
    David Bruyette

    7 Pituitary Dependent Hyperadrenocorticism in Dogs and Cats
    David Bruyette

    8 Polyuria and Polydipsia
    Jennifer L. Garcia

    9 Canine Hypothyroidism
    David Bruyette

    10 Feline Hyperthyroidism
    David Bruyette

    11 Hypoadrenocorticism in Dogs
    Patty Lathan

    12 Diabetes Mellitus in Dogs and Cats
    Jacquie S. Rand

    13 Hypoglycemia in Patients Without Diabetes Mellitus: Evaluation and Management
    Rhett Nichols

    14 Canine Autoimmune Polyglandular Syndromes
    Deborah Greco

    Section 3 Cardiovascular Disease

    15 Approach to the Patient with Suspected Cardiovascular Disease
    Ingrid Ljungvall and Jens Häggström

    16 Imaging in Cardiovascular Disease
    Valérie Chetboul

    17 Electrocardiography
    Marc S. Kraus and Anna R.M. Gelzer

    18 Pathophysiology of Heart Failure
    Barret J. Bulmer

    19 Management of Heart Failure
    Steven Rosenthal and Mark A. Oyama

    20 Ventricular Arrhythmias
    Amara H. Estrada and Romain Pariaut

    21 Supraventricular Arrhythmias
    Romain Pariaut and Amara H. Estrada

    22 Systemic Hypertension
    Rebecca L. Stepien

    23 Pulmonary Hypertension
    Heidi B. Kellihan

    24 Congenital Heart Disease
    Brian A. Scansen

    25 Valvular Heart Disease
    Michele Borgarelli

    26 Canine Myocardial Disease
    M. Lynne O’Sullivan

    27 Feline Myocardial Disease
    Virginia Luis Fuentes

    28 Pericardial Disease
    Ashley B. Saunders and Sonya G. Gordon

    Section 4 Respiratory Disease

    29 A Respiratory Pattern-Based Approach to Dyspnea
    Christopher G. Byers

    30 Feline Bronchial Asthma
    Christine M. Serafin

    31 Canine Chronic Bronchitis
    Kevin Kumrow

    32 Pulmonary Thromboembolism
    Robert Goggs

    33 Surgical Approaches to Thoracic Disease
    Raegan Wells

    34 Pleural Effusion
    Ashley Allen and Gareth Buckley

    Section 5 Critical Care Medicine

    35 Approach to the Patient in the Critical Care Setting
    Sarah Allen

    36 Fluid Therapy
    Teresa Rieser

    37 Cardiopulmonary Resuscitation
    Nathan Peterson

    38 Respiratory Monitoring in Critical Care
    Mathew Mellema

    39 Acute Respiratory Failure
    Mathew Mellema

    40 Mechanical Ventilation
    Kate Hopper and Mathew Mellema

    41 Approach to the Patient with Shock
    James W. Barr

    42 Cardiogenic Shock
    Nathan Peterson and James W. Barr

    43 Septic Shock
    James W. Barr

    44 Disorders of Heat and Cold
    Sarah Allen

    45 Acute Poisoning
    Ben O’Kelley

    46 Medical Management of Trauma and Burns
    Nathan Peterson

    47 Venomous Snake Bites
    Nathan Peterson

    Section 6 Gastrointestinal Disease

    48 Gastrointestinal Imaging
    Sarah M. Stieger-Vanegas

    49 Gastrointestinal Endoscopy
    Craig Ruaux

    50 Diseases of the Oral Cavity and Salivary Glands
    Maria Soltero-Reveira and Alexander Reiter

    51 Gastritis and Gastric Ulceration in Dogs and Cats
    Katie Tolbert

    52 Disorders of the Esophagus
    Silvia Funes and Craig Ruaux

    53 Motility Disorders of the Alimentary Tract
    Reito Neiger and Silke Salvati

    54 Exocrine Pancreatic Insufficiency in Dogs and Cats
    Panos Xenoulis

    55 Pancreatitis in the Dog
    Caroline Mansfield

    56 Diagnosis and Management of Pancreatitis in the Cat
    Craig Ruaux

    57 Rectoanal Diseases – Medical and Surgical Management
    Craig Ruaux

    58 Dysbiosis and the use of Pre-, Pro- and Synbiotics
    Jan Suchodolski

    59 Diagnosis and Management of Chronic Enteropathies
    Karin Allenspach

    Section 7 Diseases of the Liver, Gallbladder, and Bile Ducts

    60 Approach to the Patient with Liver Disease
    Emma O’Neill

    61 Imaging in Hepatobiliary Disease
    Esther Barrett

    62 Metabolic, Toxic and Neoplastic Diseases of the Liver
    Jan Rothuizen

    63 Feline Inflammatory Liver Disease
    Nicki Reed

    64 Canine Inflammatory Liver Disease
    Nick Bexfield

    65 Cirrhosis and its Consequences
    Katherine Scott

    66 Portosystemic Shunts and Microvascular Dysplasia
    Geraldine Hunt

    67 Diseases of the Gallbladder and Extrahepatic Biliary Ducts
    Ben Harris

    Section 8 Neurologic Disease

    68 The Neurologic Examination
    Alexander DeLahunta

    69 Central Nervous System Trauma
    Simon R. Platt

    70 Seizures and Movement Disorders
    Michael Podell

    71 Disorders of the Forebrain
    Sam N. Long

    72 Vestibular Disease
    Tammy Stevenson

    73 Meningoencephalitis and Meningomyelitis
    Christopher L. Mariani

    74 Diseases of the Neuromuscular Junction
    David Lipsitz

    75 Myopathies
    Marguerite F. Knipe

    76 Myelopathy
    Joan R. Coates

    77 Neuro-Ophthalmology
    Bradford J. Holmberg

    Volume II

    Section 9 Infectious Disease

    Part 1 Diagnostic Considerations

    78 Epidemiology of Infectious Disease
    Peggy L. Schmidt

    79 Laboratory Diagnosis of Infectious Disease
    Laia Solano-Gallego and Gad Baneth

    Part 2 Select Infectious Diseases and Disease Agents

    80 Canine Distemper
    David Bruyette

    81 Canine Herpes Virus
    Yvonne Dreschler

    82 Canine Viral Enteritis
    Margaret C. Barr

    83 Viral Papillomatosis
    Margaret C. Barr

    84 Canine Influenza Virus
    Ellen Collisson

    85 Feline Parvovirus
    Margaret C. Barr

    86 Feline Coronavirus
    Yvonne Dreschler

    87 Feline Leukemia Virus
    David Bruyette

    88 Feline Immunodeficency Virus (FIV)
    Tom Phillips

    89 Feline Viral Upper Respiratory Disease
    Yvonne Dreschler

    90 Rabies in Dogs and Cats
    Emily Beeler and Karen Ehnert

    91 West Nile Virus
    Tracey McNamara

    92 Ebola Virus
    Linda Kidd

    93 Ehrlichia and Anaplasma
    Pedro P. Vissotto de Paiva Diniz

    94 Salmon Poisoning Disease
    Pedro P. Vissotto de Paiva Diniz

    95 Wolbachia pipientis Infection
    Pedro P. Vissotto de Paiva Diniz

    96 Bartonellosis
    Pedro P. Vissotto de Paiva Diniz

    97 Hemotropic Mycoplasma
    Séverine Tasker

    98 Non-Hemotropic Mycoplasma, Ureaplasma and L-form Bacteria
    Joachim Spergser

    99 Spotted Fever and Typhus Group Rickettsia
    Linda Kidd

    100 Lyme Borreliosis
    Merryl P. Littman

    101 Leptospirosis
    Katharine F. Lunn

    102 Yersiniosis
    Maria Grazia Pennisi

    103 Tularemia
    Linda Kidd

    104 Q Fever
    Linda Kidd

    105 Brucellosis
    Erin E. Runcan

    106 Tetanus and Botulism
    Andrea Fischer

    107 Anthrax
    Wayne E. Wingfield and Jerry J. Upp

    108 Actinomyces, Nocardiosis, and Mycobacterial Infections
    Joanna Whitney and Vanessa R. Barrs

    109 Fungal Infections
    Jane E. Sykes

    110 Protozoal and Protozoa-Like Infections
    Gad Baneth and Laia Solano-Gallego

    111 Coccidia
    Chris Adolph

    112 Surgical, Traumatic and Bite Wound Infections
    Laura L. Nelson

    113 Canine Infectious Respiratory Disease Complex
    Jonathan Dear

    Part 3 Therapeutic Considerations

    114 Antimicrobial Therapy in Dogs and Cats
    Katrina R. Viviano

    115 Antifungal Therapy
    Daniel S. Foy

    Part 4 Special Topics

    116 Nosocomial and Multi-Drug Resistant Infections
    Jason W. Stull and Scott Weese

    117 Management of Infectious Disease in Kennels and Multi-Cat Environments: Creating a Culture of Compliance
    Frank Bossong

    Section 10 Renal and Genitourinary Disease

    118 Disorders of Sodium and Water Homeostasis
    Julien Guillaumin and Stephen DiBartola

    119 Disorders of Magnesium and Phosphorus
    Rosanne Jepson

    120 Acute Kidney Injury
    Adam E. Eatroff

    121 Glomerular Disease
    Shelly L. Vaden

    122 Obstructive Uropathy
    Edward Cooper and Brian A. Scansen

    123 Urolithiasis in Small Animals
    Alice Defarges, Michelle Evason, Marilyn Dunn, and Allyson Berent

    124 Prostatic Diseases
    Serge Chalhoub

    125 Management of Chronic Renal Disease
    Jessica Quimby

    126 The Role of Dialysis
    Adam E. Eatroff

    127 Micturition and Associated Disorders
    Julie K. Byron

    128 Urinary Tract Infections
    Nicole Smee

    Section 11 Oncologic Disease

    129 Approach to the Cancer Patient
    Lisa DiBernardi

    130 Biology of Cancer and Cancer Genetics
    Mary-Keara Boss

    131 Endocrine Manifestations of Cancer: Ectopic Hormone Production
    Cory Brown

    132 Paraneoplastic Syndromes
    Cory Brown

    133 Lymphoid Leukemias, Myeloid Neoplasia and Myelodysplastic Syndrome
    Angela R. Kozicki

    134 Lymphomas
    Kristine Elaine Burgess

    135 Plasma Cell Disorders
    Orna Kristal

    136 Central Nervous System Tumors in Dogs and Cats
    David Ruslander

    137 Cancer of the Nose and Mouth
    Lauren Askin Quarterman

    138 Tumors of the Eye and Ocular Adnexa
    Erin M. Scott and Paul E. Miller

    139 Cancer of the Heart
    Nick A. Schroeder and Lisa DiBernardi

    140 Cancer of the Airway and Lung
    Joanne L. Intile

    141 Cancer of the Esophagus and Stomach
    Avenelle I. Turner

    142 Cancer of the Small and Large Intestine
    Edwin Brodsky

    143 Exocrine Pancreatic Cancer
    Avenelle I. Turner

    144 Pancreatic Endocrine Tumors
    Karen Eiler

    145 Liver and Biliary Tract Tumors
    Amanda K. Elpiner

    146 Tumors of the Urinary Tract
    Pedro A. Boria

    147 Tumors of the Male Reproductive System
    Trina Hazzah

    148 Gynecologic Cancers
    Trina Hazzah

    149 Mammary Cancer
    Julie Bulman-Fleming

    150 Tumors of Bone and Joint
    Stephanie L. Shaver, William T. N. Culp, and Robert B. Rebhun

    151 Soft Tissue Sarcomas
    Lauren Askin Quarterman

    152 Hemangiosarcoma
    Christine B. Oakley and John D. Chretin

    153 Melanoma
    Philip J. Bergman

    154 Non-melanoma Skin Cancers
    Barbara E. Kitchell

    155 Mast Cell Neoplasia
    Zachary M. Wright

    156 Apheresis in Companion Animals
    Steve Suter

    Section 12 Skin and Ear Diseases

    157 Approach to the Patient with Dermatologic Disease
    Lisa V. Reiter

    158 Principles of Therapy of Skin Diseases
    Sandra N. Koch

    159 Atopic Dermatitis
    Alison Diesel

    160 Allergic Skin Diseases
    Patrick Hensel

    161 Cutaneous Adverse Food Reactions
    Ralf S. Mueller

    162 Autoimmune and Immune-mediated Skin Diseases
    Nicole A. Heinrich

    163 Approach to Alopecia
    Linda A. Frank

    164 Sterile Papular and Nodular Skin Diseases
    Sandra Diaz

    165 Parasitic Skin Diseases
    Elizabeth E. Toops

    166 Bacterial Pyodermas
    Jennifer R. Schissler

    167 Otitis
    Sue Paterson

    168 Cutaneous Manifestations of Systemic Disease
    Kinga Gortel

    169 Superficial Necrolytic Dermatitis
    Mitchell D. Song

    170 Miscellaneous Skin Diseases
    Lisa V. Reiter and Sheila M. F. Torres

    Section 13 Diseases of Bone and Joint

    171 Skeletal Development and Homeostasis
    Matthew J. Allen and Gert J. Breur

    172 Metabolic Bone Diseases
    Keren E. Dittmer

    173 Osteoarthritis in Small Animals
    Steven A. Martinez

    174 Developmental Orthopedic Diseases
    Gert J. Breur, N. E. Lambrechts, and H. A. Towle Millard

    Section 14 Social and Ethical Issues in Veterinary Medicine

    175 Canine and Feline End of Life Care
    Robin Downing

    Section 15 Preventative Care

    176 Role of Immunization
    Melissa Kennedy

    177 Behavior Triage for Internists and the General Practitioner
    Karen Sueda

    Section 16 Laboratory Support




  • 1100.00 lei

    Hospital Medicine is the fasting growing field of Medicine, and the importance of hospitalists in the delivery of care and success of hospitals continues to increase. The practice of hospital medicine is both rewarding and challenging: hospitalists need to provide high-quality care using the best available evidence in an efficient, cost-effective manner. In recognition of the need for rapid access to essential information, this text provides a concise yet comprehensive source for busy clinicians. Essentials of Hospital Medicine provides detailed reviews of all clinical topics in inpatient medicine, including common diagnoses, hospital-acquired conditions, medical consultation, and palliative care, as well as key non-clinical topics, such as quality improvement tools, approach to medical errors, the business of medicine, and teaching tips. It is the single source needed for hospitalists striving to deliver outstanding care and provide value to their patients and hospitals.

  • 1,20000lei 1150.00 lei

    This book is a fully updated and revised second edition of a highly successful text in which a new concept of knowledge mining, based on explication and transfer of interventional knowledge of experts, has been implemented. The dedicated training program that is set out will serve the needs of all interventional operators, whether cardiologists, vascular surgeons, vascular specialists, or radiologists, enabling them to achieve a consistent expert level across the entire broad spectrum of catheter-based interventions. Operator skills – and in particular decision-making and strategic skills – are the most critical factors for the outcome of catheter-based cardiovascular interventions. Currently, such skills are commonly developed by the empirical trial and error method only. The explicit teaching, training, and learning approach adopted in this book permits the rapid transfer of interventional knowledge and enables individual operators to negotiate steep learning curves and acquire complex skills in a highly efficient manner. It will thereby offer invaluable assistance in meeting successfully the challenges of modern cardiovascular care.

  • 1230.00 lei

    This book is the new edition of this comprehensive guide to the medical and surgical management of kidney stones. Divided into three main sections, the text begins with discussion on the basic formation of kidney stones, followed by mineral metabolism and diseases that lead to the formation of stones, with the final section describing surgical management techniques. The second edition has been thoroughly revised and expanded with new topics including imaging methods, non invasive surgical techniques, and management in special cases such as pregnancy. This new edition also includes discussion on stones in children. With an internationally recognised author team led by US-based specialists, this 900-page text is highly illustrated with clinical photographs and diagrams. Previous edition published in 1995. Key Points Comprehensive guide to medical and surgical management of kidney stones Fully revised second edition, with many new topics Highly illustrated with clinical photographs and diagrams over 900 pages Internationally recognised, US-based author team

  • 1,57500lei 1300.00 lei


    Since its revolutionary first edition in 1983, Rosen's Emergency Medicine set the standard for reliable, accessible, and comprehensive information to guide the clinical practice of emergency medicine. Generations of emergency medicine residents and practitioners have relied on Rosen’s as the source for current information across the spectrum of emergency medicine practice.. The 9th Edition continues this tradition of excellence, offering the unparalleled clarity and authority you’ve come to expect from the award-winning leader in the field. Throughout the text, content is now more concise, clinically relevant, and accessible than ever before - meeting the needs of today’s increasingly busy emergency medicine practitioner.


    Delivers clear, precise information, focused writing and references; relevant, concise information; and generous use of illustrations provide definitive guidance for every emergency situation.

    Offers the most immediately relevant content of any emergency medicine reference, providing diagnostic and treatment recommendations with clear indications and preferred actions.

    Presents the expertise and knowledge of a new generation of editors, who bring fresh insights and new perspectives to the table.

    Online content includes 1,200 questions and answers, as well as select video clips showing how to best perform key procedures.

    New To This Edition:

    Includes more than 550 new figures, including new anatomy drawings, new graphs and algorithms, and new photos.

    Provides diligently updated content throughout, based on only the most recent and relevant medical literature.

    Provides improved organization in sections to enhance navigation and six new chapters: Airway Management for the Pediatric Patient; Procedural Sedation and Analgesia for the Pediatric Patient; Drug Therapy for the Pediatric Patient; Co-Morbid Medical Emergencies During Pregnancy; Drug Therapy in the Geriatric Patient; and Global and Humanitarian Emergency Medicine.

    Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.

    Table Of Contents:

    Rosen’s Emergency Medicine, 9/e


    PART I Fundamental Clinical Concepts


    1. Arway

    2. Mechanical Ventilation and Noninvasive Ventilatory Support

    3. Pain Management

    4. Procedural Sedation and Analgesia

    5. Monitoring the Emergency Patient

    6. Shock

    7. Brain Resuscitation

    8. Adult Resuscitation


    9. Fever in the Adult Patient

    10. Weakness

    11. Cyanosis

    12. Syncope

    13. Coma and Depressed Level of Consciousness

    14. Confusion

    15. Seizures

    16. Dizziness and Vertigo

    17. Headache

    18. Diplopia

    19. Red and Painful Eye

    20. Sore Throat

    21. Hemoptysis

    22. Dyspnea

     23. Chest Pain

    24. Abdominal Pain

    25. Jaundice

    26. Nausea and Vomiting

    27. Gastrointestinal Bleeding

    28. Diarrhea

    29. Constipation

    30. Acute Pelvic Pain

    31. Vaginal Bleeding

    32. Back Pain

    PART II Trauma


    33. Multiple Trauma

    34. Head Trauma

     35. Facial Trauma

    36. Spinal Injuries

    37. Neck

    38. Thoracic Trauma

    39. Abdominal Trauma

    40. Genitourinary System

    41. Peripheral Vascular Injury


    42. General Principles of Orthopedic Injuries

    43. Hand

    44. Wrist and Forearm

    45. Humerus and Elbow

    46. Shoulder

    47. Musculoskeletal Back Pain

    48. Pelvis

    49. Femur and Hip

    50. Knee and Lower Leg

    51. Ankle and Foot


    52. Wound Management Principles

    53. Foreign Bodies

    54. Mammalian Bites

    55. Venomous Animal Injuries

    56. Thermal Burns

    57. Chemical Injuries


    58. Sexual Assault

    59. Intimate Partner Violence and Abuse

    PART III Medicine and Surgery


    60. Oral Medicine

    61. Ophthalmology

    62. Otolaryngology


    63. Asthma

    64. Chronic Obstructive Pulmonary Disease

    65. Upper Respiratory Tract Infections

    66. Pneumonia

    67. Pleural Disease

    Section Three CARDIAC SYSTEM

    68. Acute Coronary Syndromes

    69. Dysrhythmias

    70. Implantable Cardiac Devices

    71. Heart Failure

    72. Pericardial and Myocardial Disease

    73. Infective Endocarditis and Valvular Heart Disease

    Section Four VASCULAR SYSTEM

    74. Hypertension

    75. Aortic Dissection

    76. Abdominal Aortic Aneurysm

    77. Peripheral Arteriovascular Disease

    78. Pulmonary Embolism and Deep Venous Thrombosis


    79. Esophagus, Stomach, and Duodenum

    80. Liver and Biliary Tract

    81. Pancreas

    82. Disorders of the Small Intestine

    83. Acute Appendicitis

    84. Gastroenteritis

    85. Large Intestine

    86. Anorectum


    87. Renal Failure

    88. Sexually Transmitted Diseases

    89. Selected Urologic Disorders

    90. Selected Gynecologic Disorders

    Section Seven NEUROLOGY

    91. Stroke

    92. Seizures

    93. Headache

    94. Delirium and Dementia

    95. Brain and Cranial Nerve Disorders

    96. Spinal Cord Disorders

    97. Peripheral Nerve Disorders

    98. Neuromuscular Disorders

    99. Central Nervous System Infections


    100. Thought Disorders

    101. Mood Disorders

    102. Anxiety Disorders

    103. Somatoform Disorders

    104. Factitious Disorders and Malingering

    105. Suicide


    106. Arthritis

    107. Tendinopathy and Bursitis

    108. Systemic Lupus Erythmatosus and the Vasculitides

    109. Allergy, Hypersensitivity, and Anaphylaxis

    110. Dermatologic Presentations


    111. Blood and Blood Components

    112. Anemia and Polycythemia

    113. White Blood Cell Disorders

    114. Disorders of Hemostasis

    115. Selected Oncologic Emergencies


    116. Acid-Base Disorders

    117. Electrolyte Disorders

    118. Diabetes Mellitus and Disorders of Glucose Homeostasis

    119. Rhabdomyolysis

    120. Thyroid and Adrenal Disorders


    121. Bacteria

    122. Viruses

    123. Rabies

    124. AIDS and HIV

    125. Parasites

    126. Tick-Borne Illnesses

    127. Tuberculosis

    128. Bone and Joint Infections

    129. Soft-Tissue Infections

    130. Sepsis Syndrome

    PART IV Environment and Toxicology

    Section One ENVIRONMENT

    131. Frostbite and Nonfreezing Cold Injuries

    132. Accidental Hypothermia

    133. Heat Illness

    134. Electrical and Lightning Injuries

    135. Scuba Diving and Dysbarism

    136. High-Altitude Medicine

    137. Drowning

    138. Radiation Injuries

    Section Two TOXICOLOGY

    139. Approach to the Poisoned Patient

    140. Substance Abuse

    141. Toxic Alcohols

    142. Alcohol-Related Disease

    143. Acetaminophen

    144. Aspirin and Nonsteroidal Agents

    145. Anticholinergics

    146. Antidepressants

    147. Cardiovascular Drugs

    148. Caustics

    149. Cocaine and Other Sympathomimetics

    150. Hallucinogens

    151. Heavy Metals

    152. Hydrocarbons

    153. Inhaled Toxins

    154. Lithium

    155. Antipsychotics

    156. Opioids

    157. Pesticides

    158. Plants, Mushrooms, and Herbal Medications

    159. Sedative Hypnotics

    PART V Special Populations


    160. Approach to the Pediatric Patient

    161. Airway Management for the Pediatric Patient

    162. Procedural Sedation and Analgesia for the Pediatric Patient

    163. Pediatric Resuscitation

    164. Neonatal Resuscitation

    165. Pediatric Trauma

    166. Fever

    167. Pediatric Respiratory Emergencies: Upper Airway Obstruction and Infections

    168. Pediatric Respiratory Emergencies: Lower Airway Obstruction

    169. Pediatric Respiratory Emergencies: Disease of the Lungs

    170. Cardiac Disorders

    171. Gastrointestinal Disorders

    172. Infectious Diarrheal Disease and Dehydration

    173. Renal and Genitourinary Tract Disorders

    174. Neurologic Disorders

    175. Musculoskeletal Disorders

    176. Drug Therapy for the Pediatric Patient

    177. Child Abuse


    178. Acute Complications of Pregnancy

    179. Co-Morbid Medical Emergencies During Pregnancy

    180. Drug Therapy in Pregnancy

    181. Labor and Delivery and Their Complications

    182. Trauma in Pregnancy


    183. Approach to the Geriatric Patient

    184. Geriatric Trauma

    185. Drug Therapy in the Geriatric Patient

    186. Abuse and Neglect of the Geriatric Patient


    187. The Immunocompromised Patient

    188. The Solid Organ Transplant Patient

    189. The Combative and Difficult Patient

    PART VI Emergency Medical Services and Disaster Preparedness

    190. Emergency Medical Service: Overview and Ground Transport

    191. Air Medical Transport

    192. Disaster Preparedness

    193. Weapons of Mass Destruction


    Public Health and Humanitarian Emergencies

    e1: Forensic Emergency Medicine

    e2: Injury Prevention and Control

    e3. Global and Humanitarian Emergency Medicine

    e4: Tactical Emergency Medical Support and Urban Search and Rescue

    The Practice of Emergency Medicine

    e5: Emergency Ultrasound

    e6: Observation Medicine and Clinical Decision Units

    e7: Multiculturalism and Care Delivery

    e8: The Geriatric Emergency Department

    e9: End of Life

    e10: Bioethics

    e11: EMTALA and Medicolegal Issues

    e12: Process Improvement and Patient Safety

    e13: Wellness, Stress, and the Impaired Physician



  • 1420.00 lei


    The definitive guide to surgical management of epilepsy in pediatric patients

    This fully revised and updated second edition of Pediatric Epilepsy Surgery, edited by internationally renowned pediatric neurosurgeons and epilepsy surgery experts Oğuz Çataltepe and George Jallo, fills a void in the literature, encompassing the full spectrum of topics related to the surgical treatment of intractable epilepsy and seizures in children. The prodigiously illustrated book and its accompanying videos feature contributions from distinguished specialists in several different countries across a wide range of disciplines.

    From epidemiology, genetics, pathology, preoperative electrophysiological assessment and neuroimaging to state-of-the-art surgical approaches, this remarkable resource covers the full depth and breadth of surgical management of pediatric epilepsy. Topics include awake anesthesia, intracranial stimulation and mapping techniques, temporal and extratemporal epilepsy surgery techniques, insular, multilobar and hemispheric surgery approaches, and diverse disconnection, neuromodulation, and ablative procedures. Insights are provided on postoperative issues including seizure control, neuropsychological and psychosocial outcomes, surgical failure and re-operation, and much more.

    Key Features

    ·         A review of topographic anatomy of the cerebral cortex and white matter with numerous illustrations provides enhanced understanding of eloquent anatomy.

    ·         Discussion of cutting-edge techniques such as stereo-electroencephalography, multi-modality imaging and tractography, endoscopic and laser ablation approaches in hypothalamic hamartomas, peri-insular quadrantotomy, and various hemispherotomy approaches.

    ·         Overview of common cortical stimulation and mapping techniques including magnetic and electrical stimulation modalities, functional MRI, and the WADA test.

    ·         13 videos demonstrate seizure semiology, stimulation, awake surgery, hemispherotomy, amygdalohippocampectomy, and endoscopic corpus callosotomy.

    This state-of-the-art resource is a must-have for epilepsy surgeons and epileptologists. It will also greatly benefit neurosurgeons, neurologists, clinical neuropsychologists, electrophysiologists, neuroradiologists, residents, fellows, and medical students involved in the assessment and surgical management of epilepsy in pediatric patients.

    This book includes complimentary access to a digital copy on


    Table of Contents


    Part I. Introduction to Epilepsy in Children
    1 Basic Considerations of Pediatric Epilepsy Surgery
    2 A Historical Review of Epilepsy Surgery and Its Application in Children
    3 Epidemiology of Intractable Epilepsy in Children
    4 Genetics in Epilepsy Surgery
    5 Surgical Neuropathology of Pediatric Epilepsy
    6 Epilepsy and Brain Plasticity
    7 Effects of Seizures and Their Comorbidities on the Developing Brain
    8 Ethical Considerations in Pediatric Epilepsy Surgery
    9 Infantile and Childhood-Onset Catastrophic Epilepsy Syndromes
    10 Epilepsy Surgery for Congenital or Early Brain Lesions
    Part II. Preoperative Assessment
    Section IIa. Preoperative Clinical and Neuropsychological Assessment
    11 Intractable Epilepsy in Children and Selection of Surgical Candidates
    12 Clinical Semiology in Preoperative Assessment
    13 Preoperative Neuropsychological and Cognitive Assessment
    Section IIb. Preoperative Electrophysiological Assessment
    14 Electroencephalography and Noninvasive Electrophysiological Assessment
    15 Invasive Electrophysiological Monitoring
    16 Extra- and Intraoperative Electrocortical Stimulation
    17 Stereoelectroencephalography
    18 Magnetoencephalography
    Section IIc. Preoperative Neuroimaging
    19 Structural Brain Imaging in Pediatric Epilepsy
    20 Functional Magnetic Resonance Imaging in Pediatric Epilepsy Surgery
    21 Application of Positron Emission Tomography and Single-Photon Emission Computed Tomography in Pediatric Epilepsy Surgery
    22 Multimodality Imaging and Coregistration
    Part III. Surgical Anatomy and Mapping Techniques
    23 Cerebral Cortex: Embryological Development and Topographical Anatomy
    24 Tractographic Anatomy of White Matter
    25 Localization of Motor Cortex and Subcortical Pathways Using Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging
    26 The Wada Test: Lateralization of Language and Memory
    27 Language Lateralization and Localization: Functional Magnetic Resonance Imaging
    28 Localization of Eloquent Cortex and White Matter Tracts Under General Anesthesia
    29 Cortical Stimulation and Mapping
    30 Subcortical Mapping During Intracranial Surgery in Children
    Part IV. Surgical Treatment of Epilepsy
    Section IVa. Anesthesia
    31 Anesthetic Considerations and Postoperative Intensive Care Unit Care in Pediatric Epilepsy Surgery
    32 Pediatric Awake Craniotomy
    Section IVb. Intracranial Electrode Placement for Invasive Monitoring
    33 Implantation of Strip, Grid, and Depth Electrodes for Invasive Electrophysiological Monitoring
    34 Stereoelectroencephalography in Children: Methodology and Surgical Technique
    Section IVc. Temporal Lobe Epilepsy and Surgical Approaches
    35 Mesial Temporal Sclerosis in Pediatric Epilepsy
    36 Anteromesial Temporal Lobectomy
    37 Selective Amygdalohippocampectomy
    38 Surgical Management of Lesional Temporal Lobe Epilepsy
    39 Surgical Management of MRI-Negative Temporal Lobe Epilepsy
    Section IVd. Extratemporal Lobe Epilepsy and