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  • 137.00 lei

    First published in 1925, this two-volume work deals with the blood's role in respiration. This first volume analyses the effect of high altitudes on the blood's ability to retain and diffuse oxygen. The text is illustrated with diagrams, maps and photographs relating to the changes human physiology undergoes at altitude, including changes in circulation rate, pulse and the nature of red corpuscles. This book will be of value to anyone with an interest in the history of medicine or in haematology.

  • 137.00 lei

    First published in 1925, this two-volume work deals with the blood's role in respiration. This second volume deals with haemoglobin as a chemical substance. The text is illustrated with diagrams and drawings relating to, among other things, haemoglobin's specificity, its manufacture in the body and how it is affected by temperature changes. This book will be of value to anyone with an interest in the history of medicine or in haematology.

  • 165.00 lei

    George Henry Falkiner Nuttall (1862–1937) was an American-British bacteriologist who made significant contributions to various aspects of medicine. In this book, which was first published 1904, Nuttall provides a record of investigations carried out in the Pathological Laboratory of the University of Cambridge, chiefly during 1902. The text presents a demonstration of blood relationships among animals by means of the precipitin test for blood. A bibliography is also included. This book will be of value to anyone with an interest in haematology and the history of science.

  • 20200lei 185.00 lei

     A concise, clinical handbook covering the whole of haematology Reflects current practice with up-to-date investigation and management Easy-to-understand and useful for all grades of medical, nursing, technical, and research staff Includes rare disorders as well as common conditions affecting both adults and children Practically focused, written by a team of experienced, practicing clinicians New to this edition Contains all the latest guidelines and a brand new chapter on rare diseases All sections and protocols on malignant haematology have been completely revised Covers all major advances in the specialty including mlaignant haematology and transfusion medicine The Oxford Handbook of Clinical Haematology provides core and concise information on the entire spectrum of blood disorders affecting both adults and children. Updated for its fourth edition, it includes all major advances in the specialty, including malignant haematology, haemato-oncology, coagulation, transfusion medicine, and red cell disorders, with a brand new chapter on rare diseases. Practically focused, and specifically designed for ease-of-use, and rapid access to the information you need, this handbook is an indispensable resource on all aspects of haematology for all trainee doctors, nurses, technicians, and research professionals. The handbook is divided into clinical approach and disease-specific areas. The clinical approach section outlines various symptoms and signs in patients with blood disease to enable the reader to formulate a sensible differential diagnosis beofre embarking on investigation and treatment. The disease-specific section is written by four authors whose expertise covers the whole breadth of diseases included in the book. All authors have contributed to national guidelines (e. g. British Committee for Standards in Haematology, BCSH) and are experts in the evidence base that exists for each topic. The Oxford Handbook of Clinical Haematology offers a concise and logical approach to caring for patients with diseases of the blood. 1: Clinical approach 2: Red cell disorders 3: White blood cell abnormalities 4: Leukaemia 5: Lymphoma 6: Myelodysplasia 7: Myeloproliferative neoplasms (MPNs) 8: Paraproteinaemias 9: Haematopoietic stem cell transplantation (SCT) 10: Haemostasis and thrombosis 11: Immunodeficiency 12: Paediatric haematology 13: Haematological emergencies 14: Supportive care 15: Protocols and procedures 16: Haematological investigations 17: Blood transfusion 18: Rare diseases A1: Haematology online A2: Charts and nomograms A3: Normal ranges

  • 210.00 lei

    Concise, portable, and user-friendly, The Washington Manual Hematology and Oncology Subspecialty Consult, 4th Edition, provides quick access to the essential information needed to evaluate a patient on a subspecialty consult service. This edition offers state-of-the-art content, including coverage of new anti-cancer drugs and new biomarkers and therapeutic targets. Ideal for fellows, residents, and medical students rotating on hematology and oncology subspecialty services, the manual is also useful as a first-line resource for internists and other primary care providers.

    Key Features:
    *Thoroughly revised to include new standards in the treatment of malignancies and hematologic disorders, mechanisms of action of new therapeutic agents, and the current use of molecular prognostic factors.
    * A new chapter on immunotherapy reviews approved and potentially approved new therapies that help you improve clinical outcomes for your patients.
    * A reorganized, consistent format throughout ensures that you can find what you need quickly and easily.
    *Comprehensive coverage addresses all areas of hematology and oncology.
    * Symptoms, signs, and problems encountered in daily practice are presented in a quick-reference bulleted format
    *Updated references are provided for readers who would like additional information on a particular topic.
    * Written by fellows and junior faculty from the Washington University School of Medicine in St. Louis.Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like:

    *Complete content with enhanced navigation
    *Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web
    *Cross-linked pages, references, and more for easy navigation
    *Highlighting tool for easier reference of key content throughout the text
    * Ability to take and share notes with friends and colleagues
    *Quick reference tabbing to save your favorite content for future use

  • 277.00 lei

    Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. For a long time th

  • 43500lei 390.00 lei

    This book provides a unique frame work for examining acute lung syndromes that arise from hematologic disorders or is defined by a hematologic abnormality as a key feature.  Acute lung processes arising from hematologic disorders can present as life-threatening conditions, and as such, the pulmonary physician or critical care physician are often directly involved in care or called upon to provide expertise. Chapters are organized into three sections, each with an emphasis on pathogenesis and current understanding of mechanisms. The text begins with the central theme of the lungs as the direct interface between the external environment and blood, description of individual components of the hematopoietic system, their function and relevance to the lungs. The second section outlines both benign and malignant primary hematologic disorders that can lead to acute pulmonary manifestations. The final section focuses on acute lung syndromes stemming from complications of transfusion and treatment. Chapters are presented in an easy-to-access format, providing information on diagnosis, management, and outcomes. This is a valuable resource for pulmonary fellows in training, pulmonologists, critical care physicians, and physicians involved in caring for patients in the ICU.

  • 451.00 lei

    This book provides the necessary information about not only the clinical aspects of caring for cancer survivors, but also the psychosocial impacts. There are multiple resources available to serve as oncology textbooks, but nothing to provide the necessary information on patient care for the non-MD members of the cancer patient management team. In the post-treatment phase, the management team must go beyond the realm of "conventional" follow-up, helping the patient to intellectually understand and emotionally grasp the path ahead. Cancer Survivorship will prove a vital tool to physicians, nurses, clinical social workers and mental health.

  • 51000lei 460.00 lei

    Designed as a practical, succinct guide, for quick reference by clinicians with everyday questions, this title guides the reader through the range of approaches available for diagnosis, management, or prevention of hemorrhagic and thrombotic diseases or disorders. Provides essential practical management for all those working in the field of hemostasis and thrombosis Includes new chapters on direct oral anticoagulants, acquired inhibitors of coagulation, and expanded discussion of thrombotic microangiopathies Covers in a clear and succinct format, the diagnosis, treatment and prevention of thrombotic and haemostatic disorders Follows templated chapter formats for rapid referral, including key points and summary boxes, and further reading Highlights controversial issues and provides advice for everyday questions encountered in the clinic

  • 515.00 lei

    his comprehensive and authoritative text summarizes current evidence and provides experienced perspectives on the etiology, diagnosis, and management of pediatric thrombotic disorders, including arterial ischemic stroke and cerebral sinovenous thrombosis. Authored by leaders in the field, individual chapters are devoted to specific anatomic sites and types of thrombosis. State-of-the-art, pediatric-focused chapters aid in diagnostic evaluation and therapeutic decision making, in settings ranging from the most routine to the most complex and challenging patient scenarios. Topics include: Extremity and Caval Deep Venous Thrombosis; Pulmonary Embolism; Cancer-Associated Thromboembolism; Infection-Associated Thromboembolism; Arterial Ischemic Stroke; Cerebral Sinovenous Thrombosis; Gastrointestinal and Visceral Thrombosis; Developmental Hemostasis; Thrombophilias; Heparin-Induced Thrombocytopenia/Thrombosis Syndrome; Venous Thromboembolism Prevention; Thrombolysis; and Novel Anticoagulants, among others. This text is a 'must-have' for practitioners in pediatric hematology, oncology, hematopoietic stem cell transplantation, neurology, hospital medicine, and intensive care.

  • 57200lei 515.00 lei

     When a biological drug patent expires, alternative biosimilar products are developed. The development of biosimilar products is complicated and involves numerous considerations and steps. The assessment of biosimilarity and interchangeability is also complicated and difficult.Biosimilar Drug Product Development presents current issues for the development of biosimilars and gives detailed reviews of its various stages and contributing factors as well as relevant regulatory pathways and pre- and post-approval issues.

  • 61200lei 550.00 lei

    The fifth edition of this practical textbook on transfusion medicine has been thoroughly revised with the latest in scientific and technological developments and edited by a leading team of international expert haematologists, including new co-editor Mark H. Yazer MD.

    ·         A succinct and user-friendly resource of transfusion medicine for clinicians, scientists and trainees with key points, charts and algorithms

    ·         Discusses practice in blood centres and hospitals including regulatory aspects, transfusion safety, production and storage, donor care, and blood transfusion in a global context

    ·         Coverage of cellular and tissue therapies and organ transplantation including stem cell collection and haematopoietic stem cell processing and storage

    ·         Review of the development of the evidence-base for transfusion medicine

    ·         Content on the clinical practice for transfusion and alternatives to transfusion

  • 552.00 lei

    Covering a full range of topics from cardiovascular and pulmonary disease to ophthalmology, hematology and pediatrics, this is the only single volume, quick reference designed for use in daily practice. The 150+ clinical prediction rules as well as the background information necessary to determine its validity and relevance are essential for every physician in a time of limited health care resources. Designed as an aid in diagnosis and treatment, these rules allow more accurate diagnosis and treatment decisions while eliminating superfluous testing.

  • 575.00 lei

    Features:

    • Presents a concise, systematic approach to all pediatric hematologic and oncologic disorders in one manual
    • Offers an alternative to bigger references which only cover either oncologic or hematologic disorders in twice as many pages
    • Presents an easy-to-read format: multiple tables, charts, and flow-diagrams for diagnosis and management of pediatric hematologic and oncologic disorders
    • Includes 2 new chapters and several expanded chapters: Diagnostic, Molecular and Genomic Methodologies for the Hematologist, Transfusion Medicine, Myelodysplasia, Myeloid Leukemias, and Lymphoid Leukemias

    Table Of Contents:

    • Dedication
    • List of Contributors
    • About the Editors
    • Preface to the Sixth Edition
    • Preface to the Fifth Edition
    • Preface to the Fourth Edition
    • Preface to the Third Edition
    • Preface to the Second Edition
    • Preface to the First Edition
    • Introduction: Historic Perspective
      • Reflection on 60 Years of Progress in Pediatric Hematology-Oncology
    • Chapter 1. Diagnostic Molecular and Genomic Methodologies for the Hematologist/Oncologist
      • Abstract
      • Clinical Molecular and Genomic Methodologies
      • Interpreting and Evaluating the Results from Clinical Genetic Testing
      • Further Reading and References
    • Chapter 2. Hematologic Manifestations of Systemic Illness
      • Abstract
      • Hematologic Manifestations of Diseases Related to Various Organs
      • Chronic Illness
      • Lead Intoxication
      • Nutritional Disorders
      • Bone Marrow Infiltration
      • Further Reading and References
    • Chapter 3. Classification and Diagnosis of Anemia in Children
      • Abstract
      • Classification and Diagnosis
      • Further Reading and References
    • Chapter 4. Lymphadenopathy and Diseases of the Spleen
      • Abstract
      • Lymphadenopathy
      • Diseases of the Spleen
      • Splenomegaly
      • Further Reading and References
    • Chapter 5. Anemia During the Neonatal Period
      • Abstract
      • Hemorrhage
      • Hemolytic Anemia
      • Failure of Red Cell Production
      • Anemia of Prematurity
      • Physiologic Anemia
      • Diagnostic Approach to Anemia in the Newborn
      • Further Reading and References
    • Chapter 6. Iron-Deficiency Anemia
      • Abstract
      • Prevalence
      • Etiologic Factors
      • Clinical Features
      • Diagnosis
      • Stages of Iron Depletion
      • Differential Diagnosis
      • Treatment
      • Further Reading and References
    • Chapter 7. Megaloblastic Anemia
      • Abstract
      • Vitamin B12 (Cobalamin) Deficiency
      • Folic Acid Deficiency
      • Clinical Features of Cobalamin and Folate Deficiency
      • Diagnosis of Cobalamin and Folate Deficiency
      • Treatment
      • Further Reading and References
    • Chapter 8. Bone Marrow Failure
      • Abstract
      • Aplastic Anemia
      • Acquired Aplastic Anemia
      • Inherited Bone Marrow Failure Syndromes
      • Fanconi Anemia
      • Dyskeratosis Congenita
      • Congenital Aplastic Anemias of Unknown Inheritance
      • Diamond–Blackfan Anemia (Congenital Pure Red Cell Aplasia)
      • Transient Erythroblastopenia of Childhood
      • Congenital Dyserythropoietic Anemia
      • Sideroblastic Anemias (Mitochondrial Diseases with Bone Marrow Failure Syndromes)
      • Severe Congenital Neutropenia and Kostmann Syndrome
      • Reticular Dysgenesis
      • Further Reading and References
    • Chapter 9. General Considerations of Hemolytic Diseases, Red Cell Membrane, and Enzyme Defects
      • Abstract
      • Clinical Features of Hemolytic Disease
      • Laboratory Findings
      • Membrane Defects
      • Paroxysmal Nocturnal Hemoglobinuria
      • Enzyme Defects
      • Further Reading and References
    • Chapter 10. Extracorpuscular Hemolytic Anemia
      • Abstract
      • Immune Hemolytic Anemia
      • NonImmune Hemolytic Anemia
      • Further Reading and References
    • Chapter 11. Hemoglobinopathies
      • Abstract
      • Sickle Cell Disease
      • Thalassemias
      • Management of the Acutely Ill Thalassemic Patient
      • Further Reading and References
    • Chapter 12. Polycythemia
      • Abstract
      • Polycythemia (Erythrocytosis) in the Newborn
      • Polycythemia in Childhood
      • Polycythemia Vera
      • Primary Familial and Congenital Polycythemia
      • Congenital Polycythemia Due to Altered Hypoxia Sensing with Normal P50
      • Congenital Polycythemia Due to Altered Hypoxia Sensing with Decreased P50
      • Other Causes of Polycythemia
      • Diagnostic Approach
      • Further Reading and References
    • Chapter 13. Disorders of White Blood Cells
      • Abstract
      • Quantitative Disorders of Leukocytes
      • Decreased Production or Intrinsic Defects of Neutrophils
      • Increased Destruction or Extrinsic Defects of Neutrophils
      • Immune Neutropenia
      • NonImmune Neutropenia
      • Eosinophils
      • Lymphocytes
      • Disorders of Leukocyte Function
      • Disorders of Adhesion and Chemotaxis
      • Disorders of Neutrophil Granules
      • Disorders of Oxidative Metabolism
      • Neutrophil Production and Destruction in Newborn Infants
      • Neutrophil Function in the Newborn
      • Further Reading and References
    • Chapter 14. Disorders of Platelets
      • Abstract
      • Thrombocytopenia in the Newborn
      • Inherited Thrombocytopenias
      • Immune Thrombocytopenic Purpura (ITP)
      • Other Causes of Thrombocytopenia
      • Thrombocytosis
      • Qualitative Platelet Disorders
      • Acquired Platelet Disorders
      • Nonthrombocytopenic Purpura
      • Further Reading and References
    • Chapter 15. Disorders of Coagulation
      • Abstract
      • Hemostatic Disorders
      • Hemostasis in the Newborn
      • Detection of Hemostatic Defects
      • Acquired Coagulation Factor Disorders
      • Inherited Coagulation Factor Disorders
      • von Willebrand Disease
      • Rare Coagulation Factor Disorders (FII, V, VII, X, XI, XIII, Fibrinogen Deficiencies)
      • Thrombotic Disorders
      • Venous Thrombosis
      • Arterial Thrombosis
      • Antiphospholipid Antibody Syndrome
      • Hereditary Thrombotic Disorders
      • Thrombotic Disorders in Newborns
      • Antithrombotic Agents
      • Antithrombotic Therapy in Special Conditions
      • Further Reading and References
    • Chapter 16. Lymphoproliferative Disorders
      • Abstract
      • Lymphoproliferative Disorders
      • Further Reading and References
    • Chapter 17. Myelodysplastic Syndromes and Myeloproliferative Disorders
      • Abstract
      • Myelodysplastic Syndromes
      • Juvenile Myelomonocytic Leukemia
      • Myeloproliferative Neoplasms
      • CML, BCR–ABL1 Positive
      • Essential Thrombocythemia and Polycythemia Vera
      • Primary Myelofibrosis
      • Further Reading and References
    • Chapter 18. Acute Lymphoblastic Leukemia
      • Abstract
      • Incidence of ALL
      • Etiology
      • Clinical Features of ALL
      • Prognostic Factors
      • Treatment
      • Infant Leukemia
      • Philadelphia-Positive ALL
      • Down Syndrome and ALL
      • Relapse in Children with ALL
      • Future Drugs in ALL Therapy
      • Further Reading and References
    • Chapter 19. Acute Myeloid Leukemia
      • Abstract
      • Incidence and Epidemiology
      • Etiology and Predisposing Conditions
      • Clinical Features
      • Diagnosis
      • Classification of AML
      • Treatment
      • Novel Therapeutic Approaches
      • Acute Promyelocytic Leukemia
      • AML Special Subgroups
      • Further Reading and References
    • Chapter 20. Histiocytosis Syndromes
      • Abstract
      • Langerhans Cell Histiocytosis
      • Other Histiocytic Disorders
      • Macrophage Mediated Disorders
      • Further Reading and References
    • Chapter 21. Hodgkin Lymphoma
      • Abstract
      • Etiology and Epidemiology
      • Risk Factors
      • Biology
      • Pathology
      • Clinical Presentation
      • Diagnostic Evaluation and Staging
      • Prognostic Factors
      • Treatment
      • Long-Term Complications
      • Follow-Up Evaluations
      • Further Reading and References
    • Chapter 22. Non-Hodgkin Lymphoma
      • Abstract
      • Introduction
      • Incidence and Epidemiology
      • Pathologic Classification
      • Clinical Features
      • Diagnosis
      • Staging
      • Prognosis
      • Management
      • Lymphoblastic Lymphoma
      • B Lineage NHL
      • Further Reading and References
    • Chapter 23. Central Nervous System Malignancies
      • Abstract
      • Epidemiology
      • Pathology
      • Clinical Manifestations
      • Genetic Syndromes Associated with Pediatric Brain Tumors
      • Diagnostic Evaluation
      • Treatment
      • Astrocytomas
      • Medulloblastoma
      • Relapsed Medulloblastoma
      • Brain Stem Tumors
      • Ependymomas
      • Optic Glioma
      • Craniopharyngiomas
      • Intracranial Germ Cell Tumors
      • Malignant Brain Tumors in Infants and Children Less Than 3 Years of Age
      • Further Reading and References
    • Chapter 24. Neuroblastoma
      • Abstract
      • Epidemiology
      • Predisposition
      • Pathology and Biology
      • Clinical Features
      • Diagnosis and Staging
      • Treatment
      • Prognosis, Risk Stratification, and Therapy
      • Post-Therapy Monitoring
      • Special Treatment Considerations
      • Neuroblastoma in the Adolescent and Young Adult
      • Further Reading and References
    • Chapter 25. Renal Tumors
      • Abstract
      • Wilms’ Tumor
      • Nephroblastomatosis
      • Congenital Mesoblastic Nephroma
      • Clear Cell Sarcoma of the Kidney
      • Rhabdoid Tumor of the Kidney
      • Renal Cell Carcinoma
      • Further Reading and References
    • Chapter 26. Rhabdomyosarcoma and Other Soft-Tissue Sarcomas
      • Abstract
      • Incidence and Epidemiology
      • Pathologic and Genetic Classification
      • Clinical Features
      • Diagnostic Evaluation
      • Staging
      • Prognosis
      • Treatment
      • Follow-Up After Completion of Therapy
      • Recurrent Disease
      • Future Perspectives
      • Further Reading and References
    • Chapter 27. Malignant Bone Tumors
      • Abstract
      • Osteosarcoma
      • Ewing Sarcoma Family of Tumors
      • Other Bone Tumors
      • Further Reading and References
    • Chapter 28. Retinoblastoma
      • Abstract
      • Incidence
      • Classification
      • 13q Deletion Syndrome
      • Risk for Second Malignant Neoplasms
      • Pathology
      • Clinical Features
      • Diagnostic Procedures
      • Treatment
      • Posttreatment Management
      • Future Perspectives
      • Further Reading and References
    • Chapter 29. Germ Cell Tumors
      • Abstract
      • Incidence
      • Pathology
      • Clinical Features
      • Diagnostic Evaluation
      • Tumor Markers
      • Staging
      • Treatment
      • Further Reading and References
    • Chapter 30. Hepatic Tumors
      • Abstract
      • Incidence
      • Epidemiology
      • Pathology
      • Clinical Features
      • Diagnostic Evaluation
      • Staging
      • Treatment
      • Follow-up
      • Prognosis
      • Further Reading and References
    • Chapter 31. Hematopoietic Stem Cell Transplantation
      • Abstract
      • Allogeneic Stem Cell Transplantation
      • HSC Sources, Collection, and Manipulation
      • Engraftment
      • Complications of HSCT
      • Late Sequelae of Stem Cell Transplantation
      • Further Reading and References
    • Chapter 32. Management of Oncologic Emergencies
      • Abstract
      • Metabolic Emergencies
      • Cardiothoracic Emergencies
      • Abdominal Emergencies
      • Renal Emergencies
      • Neurologic Emergencies
      • Endocrine Emergencies
      • Treatment-Associated Emergencies
      • Further Reading and References
    • Chapter 33. Supportive Care of Patients with Cancer
      • Abstract
      • Management of Infectious Complications
      • Infection Prophylaxis
      • Recognition and Management of Nausea and Vomiting
      • Mucositis
      • Pain Management
      • Nutritional Status of the Oncology Patient
      • Utilization of Hematopoietic Growth Factors
      • Management of Acute Radiation Side Effects
      • Management of CVCs
      • Posttreatment Immunizations
      • Palliative Care
      • Further Reading and References
    • Chapter 34. Evaluation, Investigations, and Management of Late Effects of Childhood Cancer
      • Abstract
      • Musculoskeletal System
      • Cardiovascular System
      • Respiratory System
      • Central Nervous System
      • Endocrine System
      • Genitourinary System
      • Ocular System
      • Auditory System
      • Gastrointestinal System
      • Immunologic System
      • Obesity
      • Second Malignant Neoplasms
      • Psychosocial Issues
      • Further Reading and References
    • Chapter 35. Psychosocial Aspects of Cancer for Children and Their Families
      • Abstract
      • Time of Diagnosis
      • Treatment Initiation
      • Illness Stabilization
      • During Relapses and Recurrences
      • Treatment Outcomes: The Unsuccessful Course
      • Treatment Outcomes: The Successful Course
      • Conclusion
      • Further Reading and References
    • Chapter 36. Blood Banking Principles and Practices
      • Abstract
      • Introduction
      • Donor Selection and Collection
      • Component Preparation
      • Blood Component Modifications
      • Special Pediatric Population Needs
      • Administration
      • Summary
      • Further Reading and References
    • Appendix 1. Hematological Reference Values
      • Fetal and Cord Blood Hematologic Value
      • Red Cell Values and Related Serum Values
      • White Cell Values
      • Platelet Values
      • Coagulation Values
      • Bone Marrow Cells
    • Appendix 2. Biological Tumor Markers
    • Index

  • 82100lei 600.00 lei

    ​This book is an up-to-date reference on all aspects of anticoagulation and hemostasis in neurosurgery.  After an opening section on basic principles and drug classes in current use, detailed consideration is given to coagulation issues relevant to all patients, not just neurosurgical ones. The coverage includes, for example, deep vein thrombosis, pulmonary embolism, and disseminated intravascular coagulation. A variety of important issues specific to neurosurgical practice are then addressed, and a summary of current guidelines and best practices is provided. By bringing together the latest knowledge from across the discipline, this book will serve as a sound basis for informed decision making in surgical practice. It will be of daily value for neurosurgeons and trainees worldwide and will also be of interest to emergency room physicians, surgeons in general, critical care physicians, neurologists, and hospital medicine specialists.

  • 600.00 lei

    Written by a team of international experts, this book provides an authoritative overview and practical guide to the molecular biology and genetic basis of haematologic cancers including leukemia. Focusing on the importance of cytogenetics and related assays, both as diagnostic tools and as a basis for translational research, this is an invaluable guide for basic and clinical researchers with an interest in medical genetics and haemato–oncology.

    The Genetic Basis of Haematological Cancers reviews the etiology and significance of genetic and epigenetic defects that occur in malignancies of the haematopoietic system. Some of these chromosomal and molecular aberrations are well established and already embedded in clinical management, while many others have only recently come to light as a result of advances in genomic technology and functional investigation. The book includes seven chapters written by clinical and academic leaders in the field, organised according to haematological malignancy sub–type.
    Each chapter includes a background on disease pathology and the genetic abnormalities most commonly associated with the condition. Authors present in–depth discussions outlining the biological significance of these lesions in pathogenesis and progression, and their use in diagnosis and monitoring response to therapy. The current or potential role of specific abnormalities as novel therapeutic targets is also discussed. There is also a full colour section containing original FISH, microarrays and immunostaining images.

  • 660.00 lei

    • Enables both the haematologist and laboratory scientist to identify blood cell features, from the most common to the more obscure
    • Provides essential information on methods of collection, blood film preparation and staining, together with the principles of manual and automated blood counts
    • Completely revised and updated, incorporating much newly published information: now includes advice on further tests when a specific diagnosis is suspected
    • 400 high quality photographs to aid with blood cell identification • Highlights the purpose and clinical relevance of haematology laboratory tests throughout

  • Leukaemia Diagnosis, 5th Edition
    La comanda in aprox. 4 saptamani
    75000lei 700.00 lei

    From the bestselling author, Barbara J. Bain, the new edition of this practical reference on the principles of leukaemia diagnosis and classification has been fully updated, and incorporates the recently revised WHO classification.

    Leukaemias are a very heterogeneous group of diseases, which differ from each other in aetiology, pathogenesis, prognosis and responsiveness to treatment. Accurate diagnosis and classification are vital for the identification of specific biological entities and underpin scientific advances in this field. The detailed characterization of haematological neoplasms is also essential for the optimal management of individual patients.

    In this user-friendly guide, Professor Bain illustrates and explains how these many laboratory techniques are used for the diagnosis and classification of leukaemia and related disorders. Leukaemia Diagnosis, Fifth Edition will be highly valuable to trainee haematologists and laboratory scientists in haematology and related disciplines, and will also prove a useful reference source and teaching aid for those who already have expertise in this field. In addition, cytogeneticists and molecular geneticists will find that this book enhances their understanding of the relationship of their disciplines to the diagnosis, classification and monitoring of leukaemia and related disorders.

    Essential reading for every haematologist and haematopathologist, Leukaemia Diagnosis, Fifth Edition features

    • Over 300 high quality full colour digital images of abnormal cells in leukaemia and lymphoma supplemented by histological, cytogenetic and immunophenotyping images
    • Recent information on cytogenetic and molecular genetic abnormalities in leukaemia
    • Updated information on the characteristic immunophenotypic characteristics of different categories of leukaemia

  • 723.00 lei

     

    • Provides up-to-date knowledge on the pathogenesis and management of the syndrome
    • Presents and discusses innovative treatments in addition to standard treatment options
    • Describes the involvement of other organs or organ systems

    About this book

    This book, part of the series Rare Diseases of the Immune System, offers comprehensive, up-to-date coverage of the pathophysiology and management of the antiphospholipid syndrome (APS). Immunologic and genetic aspects are discussed and the pathogenic mechanisms responsible for such phenomena as APS-mediated thrombosis and pregnancy loss/complications are explained.

    The main clinical manifestations, classification criteria and diagnostic tools are identified, and close attention is paid to the nature of the involvement of various organs or organ systems in APS. Specific chapters describe the treatment of the different symptoms, therapies of value in avoiding recurrences, and innovative treatment approaches. The authors are senior experts in the field who are aided by younger fellows, ensuring that the book is also educationally oriented. This handy volume will be a valuable tool for postgraduates in training and professionals wishing to extend their knowledge of this specific syndrome.

    Reviews

    From the book reviews:

    “The purpose is to provide an overview of this very difficult subject that will benefit bench researchers as well as bedside clinicians. The book would serve any audience who wants to know more about antiphospholipid syndrome. … This is an excellent, up-to-date overview of antiphospholipid syndrome. It will serve as a handy tool to get more information on the topic.” (Dany V. Thekkemuriyil, Doody’s Book Reviews, February, 2015)

     

    Table of contents (20 chapters)

    ·         Genetics and Origin of Antiphospholipid Syndrome

    Soriano, Alessandra (et al.)

    Pages 1-12

    ·         The Paradox of Lupus Anticoagulant

    Banzato, Alessandra (et al.)

    Pages 13-23

    ·         Antiphospholipid Antibody Mechanisms of Thrombosis

    Meroni, Pier Luigi (et al.)

    Pages 25-35

    ·         The Pathogenic Mechanisms for Antiphospholipid Antibodies (aPL)-Mediated Pregnancy Loss

    Simone, Nicoletta (et al.)

    Pages 37-46

    ·         Classification Criteria for the Antiphospholipid Syndrome

    Derksen, Ronald H. W. M. (et al.)

    Pages 47-59

    ·         Non-classification Criteria

    Gerosa, Maria (et al.)

    Pages 61-74

    ·         Obstetric APS

    Fredi, Micaela (et al.)

    Pages 75-87

    ·         APS and the Nervous System

    Chighizola, Cecilia Beatrice (et al.)

    Pages 89-102

    ·         Antiphospholipid Syndrome (APS) and the Renal Involvement

    Mezzina, Nicoletta (et al.)

    Pages 103-112

    ·         Non-Thrombotic Hematologic Manifestations in APS

    Barcellini, Wilma (et al.)

    Pages 113-126

    ·         Heart and APS

    Denas, Gentian (et al.)

    Pages 127-150

    ·         Skin Involvement in Antiphospholipid Syndrome

    Marzano, Angelo Valerio (et al.)

    Pages 151-161

    ·         Additional Organs Involved in Antiphospholipid Syndrome: Eye, Ear-Nose-Throat, Lung, Gastroenteric System, Endocrine Glands

    Santis, Maria (et al.)

    Pages 163-168

    ·         Differential Diagnosis

    Prisco, Domenico (et al.)

    Pages 169-184

    ·         Treatment of Thrombosis in Antiphospholipid Syndrome

    Braham, Simon (et al.)

    Pages 185-192

    ·         Treatment of Pregnancy Complications

    Acaia, Barbara (et al.)

    Pages 193-206

    ·         Antiphospholipid Antibody Carriers

    Dall’Ara, Francesca (et al.)

    Pages 207-218

    ·         New Treatments

    Chighizola, Cecilia Beatrice (et al.)

    Pages 219-232

    ·         Secondary Antiphospholipid Syndrome

    Rahman, Anisur (et al.)

    Pages 233-248

    ·         The

    Rodríguez-Pintó, Ignasi (et al.)

    Pages 249-262

  • 745.00 lei

    The first book on clinical guide to transplantation in lymphoma to present cutting edge knowledge on how to integrate, transplantation and novel therapies in patients with lymphoid malignancies • Provides practical management guidance on how to integrate, transplantation and novel therapies in patients with lymphoid malignancies • Covers an overview of transplantation in lymphoma, and management of the lymphoid malignancies • Discusses organizational aspects of transplant patients and managing a transplant program • Appendices provide practical quick-reference information on follow-up after autologous and allogenic stem cell transplantation in lymphoma

  • 772.00 lei

     

    • A clinically oriented, compact, and up-to-date overview on all aspects of infections in hematology patients
    • Identifies the typical pathogens to be considered in different subgroups of patients
    • Presents clinical, imaging and laboratory-based diagnostic techniques and discusses the therapeutic strategies appropriate to different situations
    • Considers various prophylactic strategies

    About this book

    Infections are among the most frequent complications in patients with hematological malignancies and in those undergoing high-dose chemotherapy and autologous hematopoietic stem cell transplantation. A profound knowledge on the epidemiology, diagnostic approaches, treatment modalities and prophylactic strategies is essential for the clinical management of these complications in patients who are often severely immunocompromised owing to their underlying diseases and in particular, the intensive myelosuppressive chemo and immunotherapy. This textbook provides a clinically oriented, compact and up-to-date overview on infections in hematology patients and their management. The typical pathogens to be considered in different subgroups of patients are identified and further aspects of the microbiological background are explored.

    Clinical, imaging, and laboratory-based diagnostic techniques are discussed and therapeutic strategies appropriate to different situations are then presented, with due attention to the pitfalls, toxicities and interactions that can arise during antimicrobial treatment. Strategies to prevent infection are also outlined, encompassing antimicrobial prophylaxis, isolation procedures, hospital hygiene, protective immunization and the use of hematopoietic growth factors.

    Reviews

    “This is a comprehensive review of the risk factors, microbiology, prophylaxis, and management of infections in patients with hematological malignancies. … The audience includes students, residents, and practitioners who care for patients with hematological malignancies, and the book targets this group well. … Physicians who care for patients with hematological malignancies need a book like this to give them a comprehensive overview of the support and management of infections in these patients.” (Joseph C. Alvarnas, Doody's Book Reviews, May, 2015)

     

    Table of contents (18 chapters)

     

    ·         Infections in Patients with Acute Leukemia

    Rolston, Kenneth V. I.

    Pages 3-23

    ·         Infections in Patients with Malignant Lymphomas

    Rolston, Kenneth V. I.

    Pages 25-37

    ·         Consequences from Specific Treatment Modalities

    Maschmeyer, Georg

    Pages 39-47

    ·         Infections After High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation

    Nucci, Marcio (et al.)

    Pages 49-61

    ·         Microbiological Background

    Akova, Murat

    Pages 63-87

    ·         The Diagnostic Approach to the Febrile Neutropenic Patient: Clinical Considerations

    Bow, Eric J.

    Pages 91-111

    ·         Diagnostic Radiology in Hematological Patients with Febrile Neutropenia

    Heussel, Claus Peter

    Pages 113-135

    ·         Risk Stratification in Febrile Neutropenic Patients

    Paesmans, Marianne

    Pages 137-152

    ·         Fever of Unknown Origin: Treatment According to Risk Assessment

    Maschmeyer, Georg

    Pages 155-163

    ·         Pulmonary Complications

    Maschmeyer, Georg

    Pages 165-185

    ·         Vascular Catheter-Related Infections

    Dababneh, Luma (et al.)

    Pages 187-195

    ·         Gastrointestinal Complications

    Blijlevens, Nicole M. A.

    Pages 197-210

    ·         Central Nervous System Infections

    Schmidt-Hieber, Martin

    Pages 211-226

    ·         Antibacterial Agents

    Kern, Winfried V.

    Pages 229-258

    ·         Antifungal Agents

    Thompson, George R. (et al.)

    Pages 259-272

    ·         Antimicrobial Prophylaxis in Hematology

    Girmenia, Corrado (et al.)

    Pages 275-296

    ·         Infection Control and Hospital Epidemiology in Hematology Units

    Weisser, Maja (et al.)

    Pages 297-313

    ·         Myeloid Growth Factors

    Link, Hartmut

    Pages 315-324

  • 86600lei 780.00 lei

    This authoritative new book provides a comprehensive overview of diagnostic and therapeutic strategies in hematopoietic cell transplantation, explaining key concepts, successes, controversies and challenges. The authors and editors discuss current and future strategies for major challenges, such as graft-versus-host-disease, including new prophylaxis and treatments. They also discuss long-term complications, such as second malignancies and cardiovascular complications. Chapters are written by leading world experts, carefully edited to achieve a uniform and accessible writing style. Each chapter includes evidence-based explanations and state-of-the-art solutions, providing the reader

  • 845.00 lei

    Features

    • Histological images and their quantitative examination by cytometry presented side by side
    • Over 350 high-quality images
    • Based on WHO classification of hematopoietic tumors
    • Detailed and up-to-date criteria for diagnosis
    • Systematic approach including basic cases and complicated problem areas

    Summary

    This third edition is the product of the author’s 25 years of experience with flow cytometry; although it covers the wide spectrum of hematopoietic tumors, the focus remains on most important clinical diagnoses, such as acute promyelocytic leukemia, identification of blasts, identification of clonal B-cell population, differentiating mature versus immature T-cell proliferations, deferential diagnosis between hematogones and B-ALL or distinction between chronic and acute monocytic proliferations. All hematopathologists and neoplastic hematologists will find this an important resource for keeping up to date with developments in clinical practice.

  • 845.00 lei

    Hematologic malignancies were the first human cancers to be studied in depth at the molecular level, and recent years have seen important advances in treatment. This comprehensive reference book covers the full range of hematologic malignancies, including all subtypes of leukemias, lymphomas, and plasma cell dyscrasias. Authored by internationally known experts, each chapter emphasizes diagnostic work-up, staging, and therapeutic approaches. Up-to-date hematopathology, treatment, and outcomes data are presented in a way which is directly applicable to patient care. Highly illustrated with color images, graphs, flowcharts and treatment algorithms, the book is perfect for quick clinical reference as well as providing detailed reference lists for further study. With its authoritative and practical focus and visually stimulating presentation, this is a key text for hematology and oncology fellows, physicians, oncology nurses, physician assistants and other healthcare workers in the field of oncology. Covers epidemiology, etiology, risk-factors, clinical presentation, diagnosis, staging and treatment strategies for each disease subset Color images, graphs, flowcharts, algorithms and tables enhance the presentation and clinical utility of the text Extensive reference lists enable further reading and study

  • 1,16300lei 980.00 lei

    First published in 2006, the bestselling Wintrobe's Atlas of Clinical Hematologyhas now been comprehensively updated by a brand-new editorial team to bring you state-of-the-art pictorial coverage of the complete range of hematologic conditions. Thousands of meticulous, full-color images capture the characteristic appearance of each pathologic entity, and concise descriptions point out features of diagnostic importance. The result is a peerless reference to facilitate confident diagnosis in hematology.

    Features:

    Access the latest knowledge in the field with more than 30% new or updated content - including expanded coverage of acute lymphoblastic leukemia (ALL); revised diagnostic criteria for fluorescent in situ hybridization (FISH); enhanced information on flow cytometry; new coverage of genetic screens, circulating DNA analysis, RT-PCR, exosome analysis, and evaluation of epigenetic abnormalities; completely new chapters on hemostasis and platelets as well as on plasma cell disorders and on benign diseases of leukocytes, spleen, and immunoglobins; and much more.Vividly visualize the presentation of every hematologic disorder thanks to thousands of crisp, full-color images, hundreds of them new to this edition.Locate the information you need more easily through a new, highly templated format that expedites navigation, as well as a new index of figures by disorder.Easily find additional in-depth answers inside Wintrobe's Clinical Hematology, the best-selling comprehensive reference in the field, since this Atlas now features a parallel organization.Your book purchase includes a complimentary download of the enhanced eBook for iOS, Android, PC & Mac. Take advantage of these practical features that will improve your eBook experience: The ability to download the eBook on multiple devices at one time - providing a seamless reading experience online or offlinePowerful search tools and smart navigation cross-links that allow you to search within this book, or across your entire library of VitalSource eBooksMultiple viewing options that enable you to scale images and text to any size without losing page clarity as well as responsive designThe ability to highlight text and add notes with one click

  • 1,10100lei 990.00 lei


    Perfect for radiation oncology physicians and residents needing a multidisciplinary, treatment-focused resource, this updated edition continues to provide the latest knowledge in this consistently growing field. Not only will you broaden your understanding of the basic biology of disease processes, you'll also access updated treatment algorithms, information on techniques, and state-of-the-art modalities. The consistent and concise format provides just the right amount of information, making Clinical Radiation Oncology a welcome resource for use by the entire radiation oncology team.
    Features: • Content is templated and divided into three sections -- Scientific Foundations of Radiation Oncology, Techniques and Modalities, and Disease Sites - for quick access to information.
    • Disease Sites chapters summarize the most important issues on the opening page and include a full-color format, liberal use of tables and figures, a closing section with a discussion of controversies and problems, and a treatment algorithm that reflects the treatment approach of the authors.
    • Chapters have been edited for scientific accuracy, organization, format, and adequacy of outcome data (such as disease control, survival, and treatment tolerance).
    • Allows you to examine the therapeutic management of specific disease sites based on single-modality and combined-modality approaches.
    • Features an emphasis on providing workup and treatment algorithms for each major disease process, as well as the coverage of molecular biology and its relevance to individual diseases.
    New To This Edition:

    • Two new chapters provide an increased emphasis on stereotactic radiosurgery (SRS) and stereotactic body irradiation (SBRT).
    • New Associate Editor, Dr. Andrea Ng, offers her unique perspectives to the Lymphoma and Hematologic Malignancies section.
    • Key Points are summarized at the beginning of each disease-site chapter, mirroring the template headings and highlighting essential information and outcomes.
    • Treatment algorithms and techniques, together with discussions of controversies and problems, reflect the treatment approaches employed by the authors.
    • Disease Site Overviews allow each section editor to give a unique perspective on important issues, while online updates to Disease Site chapters ensure your knowledge is current.
    • Disease Site chapters feature updated information on disease management and outcomes.
    • Four videos accessible on Expert Consult include Intraoperative Irradiation, Prostate Brachytherapy, Penile Brachytherapy, and Ocular Melanoma.
    • Thirty all-new anatomy drawings increase your visual understanding.
    • Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

  • Williams Hematology, 9E
    aproximativ 4 saptamani
    1165.00 lei

    Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields. The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis. Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.

  • 1,46800lei 1365.00 lei

    Get the expert guidance you need to offer your patients the best possible outcomes with Hematology: Basic Principles and Practice, 7th Edition. This thoroughly up-to-date text contains both unparalleled scientific content and must-know clinical guidance, so you can enhance your problem-solving skills and make optimal use of the newest diagnostic techniques and therapeutic options in this fast-changing field.

    New to this edition
    • Delivers state-of-the-art information and guidance from editors and global contributors who are at the forefront of their respective subspecialty areas.
    •  

    • Features sweeping content updates throughout, including basic science research which serves as a foundation for modern hematology, recent advances in stem cell transplantation, clinical advances in the treatment of each of the hematologic malignancies, immune checkpoint inhibitors, molecular diagnostics, transfusion medicine, and much more.
    •  

       

    • Includes several new chapters including Epigenetics and Epigenomics, Stem Cell Model of Hematologic Diseases, Multiple Myeloma, IND Enabling Processes for Cell-Based Therapies, and Immune Checkpoint Blockade in Hematologic Malignancies.
    •  

       

    • New Virtual Microscope with the ability to zoom in on high-quality digital hematopathology slides and frequent content updates accessible anywhere, any time on your favorite digital device.
    •  

       

    • Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.

  • 1,55500lei 1365.00 lei

    Written by the leading names in pediatric oncology and hematology, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color, two-volume set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children. Form a definitive diagnosis and create the best treatment plans possible with comprehensive coverage of all pediatric cancers, including less-common tumors, as well as all hematologic disorders, including newly recognized ones. Develop a thorough, understanding of the underlying science of diseases through summaries of relevant pathophysiology balanced with clear, practical clinical guidance. Nathan and Oski’s is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children. Quickly and effortlessly access the key information you need with the help of a consistent organization from chapter to chapter and from volume to volume. Stay at the forefront of your field thanks to new and revised chapters covering topics such as paroxysmal nocturnal hemoglobinuria, lysosomal storage diseases, childhood genetic predisposition to cancer, and oncology informatics. Learn about the latest breakthroughs in diagnosis and management, making this the most complete guide in pediatric hematology and oncology. Discover the latest in focused molecularly targeted therapies derived from the exponential growth of knowledge about basic biology and genetics underlying the field. Rely on it anytime, anywhere! Access the full text, images, and more at Expert Consult.

  • 1950.00 lei

    Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. · Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research · Combines the knowledge and expertise of over 170 international specialists across 106 chapters · Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance ·Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more

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