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  • 140.00 lei

    First published in 1925, this two-volume work deals with the blood's role in respiration. This second volume deals with haemoglobin as a chemical substance. The text is illustrated with diagrams and drawings relating to, among other things, haemoglobin's specificity, its manufacture in the body and how it is affected by temperature changes. This book will be of value to anyone with an interest in the history of medicine or in haematology.

  • 140.00 lei

    First published in 1925, this two-volume work deals with the blood's role in respiration. This first volume analyses the effect of high altitudes on the blood's ability to retain and diffuse oxygen. The text is illustrated with diagrams, maps and photographs relating to the changes human physiology undergoes at altitude, including changes in circulation rate, pulse and the nature of red corpuscles. This book will be of value to anyone with an interest in the history of medicine or in haematology.

  • 165.00 lei

    George Henry Falkiner Nuttall (1862–1937) was an American-British bacteriologist who made significant contributions to various aspects of medicine. In this book, which was first published 1904, Nuttall provides a record of investigations carried out in the Pathological Laboratory of the University of Cambridge, chiefly during 1902. The text presents a demonstration of blood relationships among animals by means of the precipitin test for blood. A bibliography is also included. This book will be of value to anyone with an interest in haematology and the history of science.

  • 21400lei 185.00 lei

     A concise, clinical handbook covering the whole of haematology Reflects current practice with up-to-date investigation and management Easy-to-understand and useful for all grades of medical, nursing, technical, and research staff Includes rare disorders as well as common conditions affecting both adults and children Practically focused, written by a team of experienced, practicing clinicians New to this edition Contains all the latest guidelines and a brand new chapter on rare diseases All sections and protocols on malignant haematology have been completely revised Covers all major advances in the specialty including mlaignant haematology and transfusion medicine The Oxford Handbook of Clinical Haematology provides core and concise information on the entire spectrum of blood disorders affecting both adults and children. Updated for its fourth edition, it includes all major advances in the specialty, including malignant haematology, haemato-oncology, coagulation, transfusion medicine, and red cell disorders, with a brand new chapter on rare diseases. Practically focused, and specifically designed for ease-of-use, and rapid access to the information you need, this handbook is an indispensable resource on all aspects of haematology for all trainee doctors, nurses, technicians, and research professionals. The handbook is divided into clinical approach and disease-specific areas. The clinical approach section outlines various symptoms and signs in patients with blood disease to enable the reader to formulate a sensible differential diagnosis beofre embarking on investigation and treatment. The disease-specific section is written by four authors whose expertise covers the whole breadth of diseases included in the book. All authors have contributed to national guidelines (e. g. British Committee for Standards in Haematology, BCSH) and are experts in the evidence base that exists for each topic. The Oxford Handbook of Clinical Haematology offers a concise and logical approach to caring for patients with diseases of the blood. 1: Clinical approach 2: Red cell disorders 3: White blood cell abnormalities 4: Leukaemia 5: Lymphoma 6: Myelodysplasia 7: Myeloproliferative neoplasms (MPNs) 8: Paraproteinaemias 9: Haematopoietic stem cell transplantation (SCT) 10: Haemostasis and thrombosis 11: Immunodeficiency 12: Paediatric haematology 13: Haematological emergencies 14: Supportive care 15: Protocols and procedures 16: Haematological investigations 17: Blood transfusion 18: Rare diseases A1: Haematology online A2: Charts and nomograms A3: Normal ranges

  • 31200lei 265.00 lei

    Bridging the gap between science and clinical practice, The Bethesda Handbook of Clinical Hematology, Fourth Edition , provides concise, up-to-date coverage of “need to know” information on the diagnosis and treatment of blood and bone marrow disorders. Written by nationally recognized experts and senior fellows at the National Institutes of Health, and at leading research institutions throughout the United States, this essential pocket reference is logically organized by disease category and features a reader-friendly format that includes tables, algorithms, illustrations, and bulleted lists that highlight key information.

    Discusses the pathophysiology, natural history, risk factors, diagnosis, management, and follow-up of common hematological diseases.

    Contains new information on diagnosis, treatment and management of myelodysplastic and myeloproliferative disorders; leukemias and lymphomas; disorders of hemostasis and thrombosis. Features new diagnostic and treatment strategies, updated references, and revised information throughout.

    Ideal for the student, resident, or fellow on a hematology or oncology service, as well as the internist, hospitalist, family practitioner, and pediatrician who sees patients with blood diseases.

    Perfect as an everyday reference or for board review.



  • 33700lei 300.00 lei

    This clinical casebook provides a concise, state-of-the-art review of pediatric bleeding disorders. Presented in a case-based format, each case presents a different variant of bleeding disorder, illustrates the etiology, pathology, genetics, diagnosis, and management of the disorder, and offers clinical pearls. Disorders covered include hemophilia A and B, rare factor deficiencies, von Willebrand disease, immune thrombocytopenia purpura, and platelet dysfunctions. Written by experts in the field, Pediatric Bleeding Disorders: A Clinical Casebook is a valuable resource for clinicians and practitioners treating patients with challenging coagulation issues.

  • 335.00 lei

    his comprehensive and authoritative text summarizes current evidence and provides experienced perspectives on the etiology, diagnosis, and management of pediatric thrombotic disorders, including arterial ischemic stroke and cerebral sinovenous thrombosis. Authored by leaders in the field, individual chapters are devoted to specific anatomic sites and types of thrombosis. State-of-the-art, pediatric-focused chapters aid in diagnostic evaluation and therapeutic decision making, in settings ranging from the most routine to the most complex and challenging patient scenarios. Topics include: Extremity and Caval Deep Venous Thrombosis; Pulmonary Embolism; Cancer-Associated Thromboembolism; Infection-Associated Thromboembolism; Arterial Ischemic Stroke; Cerebral Sinovenous Thrombosis; Gastrointestinal and Visceral Thrombosis; Developmental Hemostasis; Thrombophilias; Heparin-Induced Thrombocytopenia/Thrombosis Syndrome; Venous Thromboembolism Prevention; Thrombolysis; and Novel Anticoagulants, among others. This text is a 'must-have' for practitioners in pediatric hematology, oncology, hematopoietic stem cell transplantation, neurology, hospital medicine, and intensive care.

  • 370.00 lei

    This is the 13th edition of a book written for students and specialists who are interested in developing a fundamental understanding of pathology and treatment of hematologic diseases. The amount of knowledge required by hematologists to identify the best course of treatment for a patient in this field is changing rapidly and has fueled an explosion of new drugs that target pathways virtually unknown a decade ago. We are now also entering an era of effective immunotherapy for a variety of hematologic malignancies, but the long term outcomes and toxicities of these treatment approaches are still unknown. This first edition in English is a significant novelty in the history of this work. Its underlying goals, however, remain the same of the first Italian edition: to help students and specialists understand the basis, treatment and management of hematologic diseases.

  • 403.00 lei

     Pret: 403 lei 305 lei (pret valabil pana la data de 20 septembrie 2020)

     

    About this book

     

    In this book, world-renowned experts in the field of hematopoietic cell transplantation examine a range of issues and controversies relating to apheresis, with the aim of identifying current trends and best practices. Readers will find up-to-date guidance on donor evaluation, CD34+ cell mobilization strategies, options and selection of apheresis device, anticoagulation techniques in apheresis, the role of prediction algorithms in determining procedure eligibility and length, and the prevention and management of complications.

    Applications of apheresis devices in the processing of bone marrow grafts are discussed, and detailed attention is devoted to the indications and rationale for therapeutic apheresis procedures, with individual chapters focusing on therapeutic plasma exchange and immunoadsorption, red cell exchange, and extracorporeal photopheresis. Finally, the applications of apheresis in pediatric donors and in resource-limiting environments are considered. This book, featuring numerous helpful tables, algorithms, and figures, will be of high practical value for residents, fellows, faculty members and other healthcare personnel involved in hematopoietic cell transplantation.

     

    Table of contents (15 chapters)

     

    Introduction and Rationale

    Pages 1-3

    Padmanabhan, Anand (et al.)

    Administrative and Regulatory Considerations for Apheresis Collection Facilities

    Pages 5-10

    Schwartz, Joseph (Yossi) (et al.)

    FACT-JACIE Standards: Common Citations and How Best to Avoid Them

    Pages 11-21

    Gastineau, Dennis A. (et al.)

    Donor Evaluation for Hematopoietic Stem and Progenitor Cell Collection

    Pages 23-49

    Connelly-Smith, Laura S.

    Mobilization Strategies: HPC(A) Collections for Autologous Hematopoietic Cell Transplants

    Pages 51-62

    Worel, Nina

    Mobilization Strategies: HPC(A) Collections for Allogeneic Hematopoietic Cell Transplants

    Pages 63-80

    Bhamidipati, Pavan Kumar (et al.)

    Hematopoietic Progenitor Cells, Apheresis and Therapeutic Cells, T-Cells Collection: Instrumentation, Operating Parameters, and Troubleshooting

    Pages 81-100

    Burgstaler, Edwin A. (et al.)

    Anticoagulation and Other Periprocedural Considerations for Apheresis

    Pages 101-107

    Karafin, Matthew S. (et al.)

    Concepts and Rationale for Using Predictive Algorithms for Hematopoietic Progenitor Cell Apheresis Collection

    Pages 109-119

    Cottler-Fox, Michele

    Applications of Apheresis Devices in Processing Bone Marrow Grafts

    Pages 121-134

    Leitner, Gerda C.

    Therapeutic Plasma Exchange and Immunoadsorption: Indications and Implementation

    Pages 135-150

    Handisurya, Ammon (et al.)

    Red Blood Cell Exchange: When and Why?

    Pages 151-160

    Stussi, Georg (et al.)

    Extracorporeal Photopheresis in Hematopoietic Cell Transplantation

    Pages 161-186

    Hölig, Kristina (et al.)

    Prevention and Management of Apheresis Complications

    Pages 187-200

    Neyrinck, Marleen M. (et al.)

    Challenges and Optimization of Apheresis Procedures in Resource-Limiting Environments

    Pages 201-211

    Koh, Mickey B. C. (et al.)

     

     

  • 54000lei 450.00 lei

    Designed as a practical, succinct guide, for quick reference by clinicians with everyday questions, this title guides the reader through the range of approaches available for diagnosis, management, or prevention of hemorrhagic and thrombotic diseases or disorders. Provides essential practical management for all those working in the field of hemostasis and thrombosis Includes new chapters on direct oral anticoagulants, acquired inhibitors of coagulation, and expanded discussion of thrombotic microangiopathies Covers in a clear and succinct format, the diagnosis, treatment and prevention of thrombotic and haemostatic disorders Follows templated chapter formats for rapid referral, including key points and summary boxes, and further reading Highlights controversial issues and provides advice for everyday questions encountered in the clinic

  • 57000lei 470.00 lei

    The first book on clinical guide to transplantation in lymphoma to present cutting edge knowledge on how to integrate, transplantation and novel therapies in patients with lymphoid malignancies • Provides practical management guidance on how to integrate, transplantation and novel therapies in patients with lymphoid malignancies • Covers an overview of transplantation in lymphoma, and management of the lymphoid malignancies • Discusses organizational aspects of transplant patients and managing a transplant program • Appendices provide practical quick-reference information on follow-up after autologous and allogenic stem cell transplantation in lymphoma

  • 54600lei 480.00 lei

    This book identifies the various ethical challenges that arise in pediatric hematology/oncology and provides the necessary tools to overcome these challenges. Aiming to expand upon and strengthen providers’ knowledge and experience in pediatric health care ethical issues, the text positions providers to be beneficial resources to faculty, staff, patients, and families within their institution. It presents a multidisciplinary approach to sound ethical practices that is necessary to effectively care for these patients and their families. The book reviews the principles of ethical decision-making, the unique difficulties in using children as research subjects, common ethical conundrums involved in providing end-of-life care, and general moralities of professional practice. 
     
    Written by experts in their fields, Ethical Issues in Pediatric Hematology/Oncology is an innovative and valuable resource for clinicians, practitioners, and trainees who work in the field of pediatric hematology/oncology. 
     

  • 505.00 lei

    This book provides the necessary information about not only the clinical aspects of caring for cancer survivors, but also the psychosocial impacts. There are multiple resources available to serve as oncology textbooks, but nothing to provide the necessary information on patient care for the non-MD members of the cancer patient management team. In the post-treatment phase, the management team must go beyond the realm of "conventional" follow-up, helping the patient to intellectually understand and emotionally grasp the path ahead. Cancer Survivorship will prove a vital tool to physicians, nurses, clinical social workers and mental health.

  • 59400lei 505.00 lei

    Make sure you are thoroughly prepared to work in a clinical lab. Rodak's Hematology: Clinical Principles and Applications, 6th Edition uses hundreds of full-color photomicrographs to help you understand the essentials of hematology. This new edition shows how to accurately identify cells, simplifies hemostasis and thrombosis concepts, and covers normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origins. Easy to follow and understand, this book also covers key topics including: working in a hematology lab; complementary testing areas such as flow cytometry, cytogenetics, and molecular diagnostics; the parts and functions of the cell; and laboratory testing of blood cells and body fluid cells. UPDATED nearly 700 full-color illustrations and photomicrographs make it easier for you to visualize hematology concepts and show what you'll encounter in the lab, with images appearing near their mentions in the text to minimize flipping pages back and forth. UPDATED content throughout text reflects latest information on hematology. Instructions for lab procedures include sources of possible errors along with comments. Hematology instruments are described, compared, and contrasted. Case studies in each chapter provide opportunities to apply hematology concepts to real-life scenarios. Hematology/hemostasis reference ranges are listed on the inside front and back covers for quick reference. A bulleted summary makes it easy for you to review the important points in every chapter. Learning objectives begin each chapter and indicate what you should achieve, with review questions appearing at the end. A glossary of key terms makes it easy to find and learn definitions. NEW! Additional content on cell structure and receptors helps you learn to identify these organisms. NEW! New chapter on Introduction to Hematology Malignancies provides and overview of diagnostic technology and techniques used in the lab.

  • 52000lei 310.00 lei

     

    Pret: 520 lei 330 lei (pret valabil pana la data de 29 septembrie 2020)


    Reviews the most current and novel treatment strategies for NHL

    Supplemented with numerous color illustrations, photographs, and tables

    Written by worldwide experts in the field

     

    About this book

     

    This text provides a state-of-the-art overview on Non-Hodgkin's lymphoma (NHL) in children and adolescents. The volume is divided into seven sections, each of which focuses on a critical component of pediatric NHL, including history and epidemiology, pathology and molecular biology, disease evaluation and response, common and rare sub-types of NHL, and current and novel treatment strategies. The text also comprehensively reviews the late effects of treatment, quality of patient life, and NHL treatment in countries with limited resources.

    Written by experts in the field, Non-Hodgkin's Lymphoma in Childhood and Adolescence is a valuable resource for clinicians and practitioners who treat children and adolescents with NHL.

    Table of contents (28 chapters)

    History of Diagnoses and Treatment Strategies in Pediatric Non-Hodgkin’s Lymphomas

    Pages 3-13

    Mann, Georg

    Epidemiology of Non-Hodgkin Lymphomas in Childhood and Adolescence

    Pages 15-22

    Thacker, Nirav (et al.)

    Diagnosis and Classification

    Pages 23-29

    Molina, Thierry Jo

    Pathogenesis of B-Cell Lymphoma

    Pages 33-50

    Wagener, Rabea (et al.)

    Pathogenesis of T-Non-Hodgkin’s Lymphoma

    Pages 51-56

    Bond, Jonathan (et al.)

    The Pathogenesis of Anaplastic Large Cell Lymphoma

    Pages 57-65

    Turner, Suzanne Dawn

    Pathology

    Pages 67-95

    Kornauth, Christoph (et al.)

    Genetic Predisposition to Non-Hodgkin Lymphoma

    Pages 97-110

    Haas, Oskar A. (et al.)

    Response Assessment in Pediatric Non-Hodgkin Lymphoma

    Pages 113-118

    Truong, Tony H. (et al.)

    Minimal Disseminated and Minimal Residual Disease in Pediatric Non-Hodgkin Lymphoma

    Pages 119-129

    Mussolin, Lara (et al.)

    Prognostic Factors in Childhood and Adolescent Non-Hodgkin Lymphoma

    Pages 131-149

    Pillon, Marta (et al.)

    Lymphoblastic Lymphoma

    Pages 153-164

    Burkhardt, Birgit (et al.)

    Burkitt Lymphoma and Diffuse Large B-Cell Lymphoma

    Pages 167-183

    Egan, Grace (et al.)

    Primary Mediastinal and Gray Zone Lymphomas

    Pages 185-193

    Giulino-Roth, Lisa (et al.)

    Epstein-Barr Virus-Associated Post-Transplantation Lymphoproliferative Disease

    Pages 195-211

    Geerlinks, Ashley V. (et al.)

    Pediatric-Type Follicular Lymphoma (PTFL)

    Pages 213-219

    Attarbaschi, Andishe

    Marginal Zone Lymphoma

    Pages 221-227

    Burkhardt, Birgit

    Primary Central Nervous System Lymphoma

    Pages 229-238

    Abla, Oussama (et al.)

    Rare B-Cell Non-Hodgkin’s Lymphomas in Childhood and Adolescence

    Pages 239-247

    Beishuizen, Auke (et al.)

    Anaplastic Large Cell Lymphoma in Children and Adolescents

    Pages 251-262

    Lowe, Eric J. (et al.)

    Peripheral T-Cell Lymphoma

    Pages 263-269

    Mellgren, Karin (et al.)

    Extranodal NK-/T-Cell Lymphomas and EBV+ Lymphoproliferative Diseases of Childhood

    Pages 271-279

    Wanitpongpun, Chinadol (et al.)

    Cutaneous T-Cell Lymphomas in Childhood and Adolescence

    Pages 281-291

    Willemze, Rein

    Principles of Immunotherapy

    Pages 295-304

    Goldman, Stanton (et al.)

    Hematopoietic Stem Cell Transplantation

    Pages 305-313

    Mori, Tetsuya (et al.)

    Novel Therapies in Paediatric NHL

    Pages 315-335

    Burke, Amos (et al.)

    Childhood and Adolescence Non-Hodgkin Lymphomas in Low- and Middle-Income Countries

    Pages 337-351

    Ozuah, Nmazuo W. (et al.)

    Long-Term Outcomes in Survivors of Childhood and Adolescent Non-Hodgkin Lymphoma

    Pages 353-366

    Nathan, Paul C. (et al.)

     

  • 61800lei 525.00 lei

    This book provides a unique frame work for examining acute lung syndromes that arise from hematologic disorders or is defined by a hematologic abnormality as a key feature.  Acute lung processes arising from hematologic disorders can present as life-threatening conditions, and as such, the pulmonary physician or critical care physician are often directly involved in care or called upon to provide expertise. Chapters are organized into three sections, each with an emphasis on pathogenesis and current understanding of mechanisms. The text begins with the central theme of the lungs as the direct interface between the external environment and blood, description of individual components of the hematopoietic system, their function and relevance to the lungs. The second section outlines both benign and malignant primary hematologic disorders that can lead to acute pulmonary manifestations. The final section focuses on acute lung syndromes stemming from complications of transfusion and treatment. Chapters are presented in an easy-to-access format, providing information on diagnosis, management, and outcomes. This is a valuable resource for pulmonary fellows in training, pulmonologists, critical care physicians, and physicians involved in caring for patients in the ICU.

  • Blood Cells: A Practical Guide, 5th Edition
    La comanda in aproximativ 4 saptamani
    63700lei 530.00 lei

    • Enables both the haematologist and laboratory scientist to identify blood cell features, from the most common to the more obscure
    • Provides essential information on methods of collection, blood film preparation and staining, together with the principles of manual and automated blood counts
    • Completely revised and updated, incorporating much newly published information: now includes advice on further tests when a specific diagnosis is suspected
    • 400 high quality photographs to aid with blood cell identification • Highlights the purpose and clinical relevance of haematology laboratory tests throughout

  • Hematology in Practice
    La comanda in aproximativ 4 saptamani
    56500lei 540.00 lei

     Description:

    Basic principles of hematology made memorable. Build a solid understanding of hematology in the context of practical laboratory practice and principles. Visual language, innovative case studies, role-playing troubleshooting cases, and laboratory protocols bring laboratory practice to life.  Superbly organized, this reader-friendly text breaks a complex subject into easy-to-follow, manageable sections. Begin with the basic principles of hematology; discover red and white blood cell disorders; journey through hemostasis and disorders of coagulation; and then explore the procedures needed in the laboratory.

    • “Learning objectives at the beginning of each chapter
    • Special "Troubleshooting: What do you do when...." sections to promote problem solving
    • "Word Key" section that highlights and defines key medical terminology
    • Case studies that illustrate the key principles of each concept in the chapters and encourage practical critical thinking
    • End-of-chapter summaries and review questions

     

    Updated

    Current World Health Organization (WHO) categories are reflected in the chapters on acute leukemia and myeloproliferative disorders.

    Thoroughly updated and peer-reviewed to ensure currency and completeness in explanations of theory.

     

    New

    'Student Alerts' highlight critical values that students must be able to recognize in the laboratory.

    'Deeper Understanding' boxes provide additional theory on specific topics.

     

    Expanded

    Coverage of hematology automation and flow cell cytometry in a new Chapter 20, Hematology Automation and Flow Cell Cytometry.

    Many new color slides more clearly show normal structures and pathologies.

     

    Table of Contents:

     

    Cover

    Title Page

    Copyright Page

    Dedication

    Preface

    Contributors

    Reviewers

    Acknowledgments

    Contents

    List of Condensed Cases, Case Studies, and Troubleshootings Cases

    Part I: Basic Hematology Principles

    Chapter 1: Introduction to Hematology and Basic Laboratory Practice

    Introduction to Hematology

    The Microscope

    Significant Parts of the Microscope

    Care of the Microscope

    Corrective Actions in Light Microscopy

    Innovations in Microscopy

    Standard Precautions

    Personal Protective Equipment

    Safety Practices Other Than Personal Protective Equipment

    Chemical and Environmental Hazards

    Basic Concepts of Quality Assurance Plans in the Hematology Laboratory

    Quality Control Monitoring in the Hematology Laboratory

    Reference Intervals

    Delta Checks

    Reflex Testing

    Critical Values

    Preanalytic Variables

    Postanalytic Variables

    Chapter 2: From Hematopoiesis to the Complete Blood Count

    Hematopoiesis: The Origin of Cell Development

    The Spleen as an Indicator Organ of Hematopoietic Health

    Functions of the Spleen

    Potential Risks of Splenectomy

    Bone Marrow and Myeloid:Erythroid Ratio

    Alterations in Myeloid:Erythroid Ratio

    Role of Stem Cells and Cytokines

    Erythropoietin

    Bone Marrow Analysis

    Bone Marrow Procedure

    Bone Marrow Report

    Complete Blood Count

    Morphologic Classification of Anemias

    Calculating Red Blood Cell Indices and Their Role in Indicating Sample Integrity

    Value of Red Blood Cell Distribution Width

    Critical Values

    Clinical Approach to Anemias

    Chapter 3: Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology

    Basic Red Blood Cell Production

    Red Blood Cell Maturation

    Features of Red Blood Cell Development

    Red Blood Cell Membrane Development and Function

    Composition of Lipids in the Interior and Exterior Layers

    Composition of Proteins in the Lipid Bilayers: Integral Proteins

    Cytoskeleton: Peripheral Proteins

    Red Blood Cell Metabolism

    Abnormal Red Blood Cell Morphology

    Variations in Red Blood Cell Size

    Variations in Red Blood Cell Color

    Variations in Red Blood Cell Shape

    Red Blood Cell Inclusions

    Value of the Reticulocyte Count

    Chapter 4: Hemoglobin Function and Principles of Hemolysis

    Hemoglobin Structure and Synthesis

    Genetics and Chain Formation of Hemoglobin

    Hemoglobin Function

    Oxygen Dissociation Curve

    Abnormal Hemoglobins

    Hemolysis

    Types and Physiology of Hemolysis

    Laboratory Evidence of Hemolysis

    Classifications Relevant to the Hemolytic Anemias

    Part II: Red Blood Cell Disorders

    Chapter 5: The Microcytic Anemias

    Introduction

    Iron Intake and Iron Absorption

    Iron Storage and Recycled Iron

    Iron Deficiency Anemia

    Pathophysiology and Symptoms

    Tests Used to Help Diagnose Iron Deficiency

    Treatment for Iron Deficiency

    Anemia of Chronic Disease and Inflammation: Pathophysiology, Diagnosis, and Treatment

    Sideroblastic Anemias

    Hereditary Hemochromatosis (Congenital Iron Overload)

    Thalassemia Syndromes

    Pathophysiology of Thalassemias

    Alpha Thalassemia

    Beta Thalassemia Major: Cooley’s Anemia, Mediterranean Anemia

    Thalassemia Intermedia and Beta Thalassemia Trait

    Chapter 6: The Macrocytic Anemias

    Macrocytic Anemias and the Megaloblastic Process

    Red Blood Cell Precursors in Megaloblastic Anemia

    Ineffective Erythropoiesis in Megaloblastic Anemia

    Pernicious Anemia as a Subset of Megaloblastic Anemias

    Vitamin B12 and Folic Acid: Nutritional Requirements and Metabolism

    Vitamin B12 and Folic Acid Deficiency

    Vitamin B12 Transport Into the Bone Marrow

    Clinical Features of Patients With Megaloblastic Anemia

    Hematologic Features of Megaloblastic Anemias

    Laboratory Diagnosis of Megaloblastic Anemias

    Serum Vitamin B12 Levels and Folic Acid Levels

    Serum Methylmalonic Acid and Homocysteine

    Intrinsic Factor and Parietal Cell Antibodies

    Treatment and Response of Patients With Megaloblastic Anemia

    Macrocytic Anemias That Are Not Megaloblastic

    Chapter 7: Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders

    Role of the Spleen in Red Blood Cell Membrane Disorders

    Hereditary Spherocytosis

    Genetics and Pathophysiology of Hereditary Spherocytosis

    Clinical Presentation in Hereditary Spherocytosis

    Laboratory Diagnosis of Hereditary Spherocytosis

    Treatment and Management of Hereditary Spherocytosis

    Hereditary Elliptocytosis

    Common Hereditary Elliptocytosis

    Southeast Asian Ovalocytosis

    Spherocytic Hereditary Elliptocytosis

    Hereditary Pyropoikilocytosis

    Hereditary Stomatocytosis and Hereditary Xerocytosis

    Glucose-6-Phosphate Dehydrogenase Deficiency

    Genetics of Glucose-6-Phosphate Dehydrogenase Deficiency

    Clinical Manifestations of Glucose-6-Phosphate Dehydrogenase Deficiency

    Acute Hemolytic Anemia

    Diagnosis of Glucose-6-Phosphate Dehydrogenase Deficiency

    Pyruvate Kinase Deficiency

    Miscellaneous Red Blood Cell Disorders

    Aplastic Anemia

    Fanconi’s Anemia

    Diamond-Blackfan Anemia

    Paroxysmal Nocturnal Hemoglobinuria

    Cold Agglutinin Syndrome

    Paroxysmal Cold Hemoglobinuria

    Congenital Dyserythropoietic Anemias

    Acquired Anemias of Variable External Causes

    Chapter 8: The Normochromic Anemias Caused by Hemoglobinopathies

    General Description of Hemoglobinopathies

    Sickle Cell Anemia

    Genetics and Incidence of Sickle Cell Anemia

    Pathophysiology of Sickling Process

    Clinical Considerations for Sickle Cell Anemia

    Laboratory Diagnosis

    Sickle Cell Trait

    Hemoglobin C Disease and Trait and Hemoglobin SC

    Variant Hemoglobins

    Hemoglobin S–Beta Thalassemia

    Hemoglobin E

    Hemoglobin DPunjab and Hemoglobin GPhila

    Hemoglobin OArab

    Part III: White Blood Cell Disorders

    Chapter 9: Leukopoiesis, WBC Differential, and Lymphocyte Function

    Leukopoiesis

    Stages of Leukocyte Maturation

    Features of Cell Identification

    Lymphocyte Origin and Function

    Lymphocyte Populations

    Travel Path of Lymphocytes

    Lymphocytes and Development of Immunocompetence

    Response of Lymphocytes to Antigenic Stimulation

    Lymphocyte Cell Markers and Cluster of Differentiation

    Leukocyte Count From Complete Blood Cell Count to Differential

    Manual Differential Versus Differential Scan

    Relative Versus Absolute Values

    Chapter 10: Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

    Introduction to White Blood Cell Disorders

    Quantitative Changes in White Blood Cells

    Specific Terminology Relating to Quantitative White Blood Cell Changes

    Stages of White Blood Cell Phagocytosis

    Qualitative Defects of White Blood Cells

    Toxic Changes in White Blood Cells

    Human Ehrlichiosis

    Nuclear Abnormalities: Hypersegmentation

    Hereditary White Blood Cell Disorders

    May-Hegglin Anomaly

    Alder’s Anomaly

    Pelger-Huët Anomaly

    Chédiak-Higashi Syndrome

    Reactive Lymphocytosis in Common Disease States

    Other Viral Sources of Reactive Lymphocytosis

    Effect of HIV/AIDS on Hematology Parameters

    Lipid Storage Diseases

    Common Features of a Few Lipid Storage Diseases

    Bone Marrow Cells in Lipid Storage Disorders

    Bacteria and Other Unexpected White Blood Cell Changes

    Chapter 11: Acute Leukemias

    Definition of Leukemia

    Comparing Acute and Chronic Leukemia

    Leukemia History

    Acute Myeloid Leukemia

    Epidemiology

    Clinical Features

    Laboratory Features

    Classification

    Acute Leukemias of Ambiguous Lineage

    Important Acute Myeloid Leukemia Prognostic Factors

    Acute Lymphoblastic Leukemia

    Epidemiology

    Clinical Features

    Classifications

    Prognosis in Acute Lymphoblastic Leukemia

    Chapter 12: Myeloproliferative Neoplasms

    Introduction to Myeloproliferative Neoplasms

    World Health Organization Classifications

    Chronic Myeloid Leukemia BCR-ABL1+

    Pathophysiology

    Clinical Features and Symptoms

    Peripheral Blood and Bone Marrow

    Diagnosis

    Treatment

    Prognosis

    Chronic Neutrophilic Leukemia

    Chronic Eosinophilic Leukemia Not Otherwise Specified

    Polycythemia Vera

    Pathophysiology

    Clinical Features and Symptoms

    Peripheral Blood and Bone Marrow Findings

    Diagnosis

    Treatment

    Prognosis

    Primary Myelofibrosis

    Pathophysiology

    Clinical Features and Symptoms

    Peripheral Blood and Bone Marrow Findings

    Diagnosis

    Treatment

    Prognosis

    Essential Thrombocythemia

    Pathophysiology

    Clinical Features and Symptoms

    Peripheral Blood and Bone Marrow Findings

    Diagnosis

    Treatment

    Prognosis

    Mastocytosis

    Chapter 13: Lymphoproliferative Disorders and Related Plasma Cell Disorders

    Lymphoid Malignancies

    Chronic Lymphocytic Leukemia

    Prolymphocytic Leukemia

    Hairy Cell Leukemia

    Hodgkin’s Lymphoma and Non-Hodgkin’s Lymphoma

    Sézary Syndrome

    Plasma Cell Disorders

    Plasma Cell Structure and Function

    Multiple Myeloma

    Waldenström’s Macroglobulinemia

    Chapter 14: The Myelodysplastic Syndromes

    Introduction to Myelodysplastic Syndromes

    Pathophysiology

    Chromosomal Abnormalities

    Common Features and Clinical Symptoms

    How to Recognize Dysplasia

    Classification of Myelodysplastic Syndromes

    Specific Features of 2016 World Health Organization Classification

    Prognostic Factors and Clinical Management

    Part IV: Hemostasis and Disorders of Coagulation

    Chapter 15: Overview of Hemostasis and Platelet Physiology

    Normal Hemostasis: Overview

    Vascular System

    Vasoconstriction

    Contribution of Endothelial Cells

    Evaluation of Endothelial Cells

    Platelets and Primary Hemostasis

    Platelet Structure and Physiology

    Platelet Function in Primary Hemostasis

    Platelet Properties

    Evaluation of Platelets

    Hemostatic Proteins and Secondary Hemostasis

    Coagulation Factors (Coagulation Cascade)

    Regulatory Inhibitors

    Hemostatic Protein Groups

    Fibrinolytic System

    Screening Tests for Evaluation of Bleeding Disorders

    Chapter 16: Quantitative and Qualitative Platelet Disorders

    Quantitative Disorders of Platelets

    Thrombocytopenia Related to Sample Integrity and Preanalytic Variables

    Thrombocytopenia Related to Decreased Production

    Thrombocytopenia Related to Altered Distribution of Platelets

    Thrombocytopenia Related to Immune Effect of Specific Drugs or Antibody Formation

    Thrombocytopenia Related to Consumption of Platelets

    Thrombocytosis

    Inherited Qualitative Disorders of Platelets

    Disorders of Adhesion

    Platelet Release Defects

    Acquired Defects of Platelet Function

    Vascular Disorders Leading to Platelet Dysfunction

    Chapter 17: Defects of Plasma Clotting Factors

    Plasma Clotting Factors and Hemophilias

    Evaluation of a Bleeding Disorder

    Treatment of Hemophilia A Patients

    Quality-of-Life Issues for Hemophilia A Patients

    Factor VIII Inhibitors

    Hemophilia B (Christmas Disease)

    Congenital Factor Deficiencies

    Congenital Factor Deficiencies With Bleeding Manifestations

    Congenital Factor Deficiencies in Which Bleeding Is Mild or Absent

    Factor XIII Deficiency

    Bleeding Secondary to a Chronic Disease Process

    Role of Vitamin K in Hemostasis

    Vitamin K Deficiency and Subsequent Treatment

    Chapter 18: Fibrinogen, Thrombin, and the Fibrinolytic System

    Overview of Fibrinogen in Clot Formation and Lysis

    Disorders of Fibrinogen

    Afibrinogenemia

    Hypofibrinogenemia

    Dysfibrinogenemia

    Multiple Roles of Thrombin in Hemostasis

    Fibrinolysis

    Clot Dissolution

    Naturally Occurring Inhibitors of Fibrinolysis

    Measurable Products of the Fibrinolytic System

    Disseminated Intravascular Coagulation

    Mechanism of Acute Disseminated Intravascular Coagulation

    Primary Fibrinolysis

    Clinical Symptoms and Laboratory Results in Acute Disseminated Intravascular Coagulation

    Treatment of Acute Disseminated Intravascular Coagulation

    Chapter 19: Introduction to Thrombosis and Anticoagulant Therapy

    Thrombophilia and Thrombosis—an Overview

    Physiologic and Pathologic Thrombosis

    Pathophysiology of Thrombosis

    Laboratory Diagnosis of Thrombotic Disorders

    Inherited Thrombotic Disorders

    Acquired Thrombotic Disorders

    The Laboratory’s Role in Diagnosing Thrombophilia

    Anticoagulant Therapy

    Antiplatelet Drugs

    Anticoagulant Drugs

    Alternative Anticoagulant Drugs

    Thrombolytic Drugs

    Part V: Hematology Automation, Flow Cell Cytometry, and Laboratory Procedures

    Chapter 20: Hematology Automation and Flow Cell Cytometry

    Hematology Automation

    Electrical Impedance

    Histograms

    Radiofrequency

    Opacity

    Scatterplot

    Optical Scatter

    VCS Technology

    Hydrodynamic Focusing

    Flow Cytometry

    Optical Platelet Counting and Flow Cytometry

    Instruments

    Data Reporting

    Beckman-Coulter Instrumentation

    Sysmex Instrumentation

    CellaVision Automated Digital Cell Morphology

    Abbott CELL-DYN Instrumentation

    Siemens Healthcare Advia Instrumentation

    Cerebrospinal Fluid Analysis on the Advia 120/2120

    Quality Assurance and Quality Control

    Coagulation Automation and Instruments

    Coagulation Automation

    Coagulation Instruments

    Flow Cytometry Instrumentation

    Principles of Operation

    Fluidics

    Optics

    Electronics

    Analysis

    Quality Control

    Applications of Flow Cytometry

    Chapter 21: Basic Procedures in a Hematology Laboratory

    Microhematocrit

    Modified Westergren Sedimentation Rate

    Manual Reticulocyte Procedure

    Peripheral Smear Procedure

    Performing a Manual Differential and Assessing Red Blood Cell Morphology

    Leukochek White Blood Cell and Platelet Manual Count

    Sickle Cell Screening Procedure

    Cerebrospinal Fluid and Body Fluid Cell Count and Differential

    Body Fluid Analysis on the Sysmex XE-5000

    Prothrombin Time and Activated Partial Thromboplastin Time: Automated Procedure

    Quantitative D-Dimer—Innovance on Sysmex CA7000

    Appendix A: Answers to Review Questions

    Appendix B: List of Abbreviations

     

  • 63500lei 565.00 lei

    Managing patients with thrombotic vascular disease is complex and challenging:

    • Ischemic vascular disease remains a complicated interplay of atherosclerosis and thrombosis—even with the evolution in our understanding of the pathobiology of thrombosis.
    • There has been tremendous growth in therapeutic options which are quickly finding their place in daily practice, including a remarkable expansion in the number of intravenous and oral antithrombotic agents and new antiplatelet agents

    Now more than ever, all cardiologists, hematologists, and specialists in vascular medicine, as well as other professionals, such as hospital pharmacists, who deal with prognosis and intervention in preventing thrombosis, need a resource that distills current knowledge of this important subject.

    Written and edited by today’s leading international, Therapeutic Advances in Thrombosis, 2e provides physicians with the very latest in medical and surgical advances in antithrombotic therapies. With this comprehensively updated edition you get:

    • Coverage of virtually all aspects of venous and arterial thrombotic disease and the corresponding therapies
    • Strategies to manage specific clinical conditions and how to tailor treatment to individual patient needs
    • Updated chapters covering thrombolysis in ST-elevated myocardial infarctions; thrombosis in patients with diabetes, pregnancy, and renal dysfunction
    • Special emphasis on the pharmacology of novel anticoagulants and their practical use in venous thromboembolism and atrial fibrillation.

    Plus, all chapters fully explore clinical trial designs and outcomes for particular treatment therapies, as well as contain the relevant ACC/AHA/ESC guidelines, so you can confidently apply what you learn.

  • 67400lei 580.00 lei

     

    • Provides up-to-date knowledge on the pathogenesis and management of the syndrome
    • Presents and discusses innovative treatments in addition to standard treatment options
    • Describes the involvement of other organs or organ systems

    About this book

    This book, part of the series Rare Diseases of the Immune System, offers comprehensive, up-to-date coverage of the pathophysiology and management of the antiphospholipid syndrome (APS). Immunologic and genetic aspects are discussed and the pathogenic mechanisms responsible for such phenomena as APS-mediated thrombosis and pregnancy loss/complications are explained.

    The main clinical manifestations, classification criteria and diagnostic tools are identified, and close attention is paid to the nature of the involvement of various organs or organ systems in APS. Specific chapters describe the treatment of the different symptoms, therapies of value in avoiding recurrences, and innovative treatment approaches. The authors are senior experts in the field who are aided by younger fellows, ensuring that the book is also educationally oriented. This handy volume will be a valuable tool for postgraduates in training and professionals wishing to extend their knowledge of this specific syndrome.

    Reviews

    From the book reviews:

    “The purpose is to provide an overview of this very difficult subject that will benefit bench researchers as well as bedside clinicians. The book would serve any audience who wants to know more about antiphospholipid syndrome. … This is an excellent, up-to-date overview of antiphospholipid syndrome. It will serve as a handy tool to get more information on the topic.” (Dany V. Thekkemuriyil, Doody’s Book Reviews, February, 2015)

     

    Table of contents (20 chapters)

    ·         Genetics and Origin of Antiphospholipid Syndrome

    Soriano, Alessandra (et al.)

    Pages 1-12

    ·         The Paradox of Lupus Anticoagulant

    Banzato, Alessandra (et al.)

    Pages 13-23

    ·         Antiphospholipid Antibody Mechanisms of Thrombosis

    Meroni, Pier Luigi (et al.)

    Pages 25-35

    ·         The Pathogenic Mechanisms for Antiphospholipid Antibodies (aPL)-Mediated Pregnancy Loss

    Simone, Nicoletta (et al.)

    Pages 37-46

    ·         Classification Criteria for the Antiphospholipid Syndrome

    Derksen, Ronald H. W. M. (et al.)

    Pages 47-59

    ·         Non-classification Criteria

    Gerosa, Maria (et al.)

    Pages 61-74

    ·         Obstetric APS

    Fredi, Micaela (et al.)

    Pages 75-87

    ·         APS and the Nervous System

    Chighizola, Cecilia Beatrice (et al.)

    Pages 89-102

    ·         Antiphospholipid Syndrome (APS) and the Renal Involvement

    Mezzina, Nicoletta (et al.)

    Pages 103-112

    ·         Non-Thrombotic Hematologic Manifestations in APS

    Barcellini, Wilma (et al.)

    Pages 113-126

    ·         Heart and APS

    Denas, Gentian (et al.)

    Pages 127-150

    ·         Skin Involvement in Antiphospholipid Syndrome

    Marzano, Angelo Valerio (et al.)

    Pages 151-161

    ·         Additional Organs Involved in Antiphospholipid Syndrome: Eye, Ear-Nose-Throat, Lung, Gastroenteric System, Endocrine Glands

    Santis, Maria (et al.)

    Pages 163-168

    ·         Differential Diagnosis

    Prisco, Domenico (et al.)

    Pages 169-184

    ·         Treatment of Thrombosis in Antiphospholipid Syndrome

    Braham, Simon (et al.)

    Pages 185-192

    ·         Treatment of Pregnancy Complications

    Acaia, Barbara (et al.)

    Pages 193-206

    ·         Antiphospholipid Antibody Carriers

    Dall’Ara, Francesca (et al.)

    Pages 207-218

    ·         New Treatments

    Chighizola, Cecilia Beatrice (et al.)

    Pages 219-232

    ·         Secondary Antiphospholipid Syndrome

    Rahman, Anisur (et al.)

    Pages 233-248

    ·         The

    Rodríguez-Pintó, Ignasi (et al.)

    Pages 249-262

  • 600.00 lei

    Written by a team of international experts, this book provides an authoritative overview and practical guide to the molecular biology and genetic basis of haematologic cancers including leukemia. Focusing on the importance of cytogenetics and related assays, both as diagnostic tools and as a basis for translational research, this is an invaluable guide for basic and clinical researchers with an interest in medical genetics and haemato–oncology.

    The Genetic Basis of Haematological Cancers reviews the etiology and significance of genetic and epigenetic defects that occur in malignancies of the haematopoietic system. Some of these chromosomal and molecular aberrations are well established and already embedded in clinical management, while many others have only recently come to light as a result of advances in genomic technology and functional investigation. The book includes seven chapters written by clinical and academic leaders in the field, organised according to haematological malignancy sub–type.
    Each chapter includes a background on disease pathology and the genetic abnormalities most commonly associated with the condition. Authors present in–depth discussions outlining the biological significance of these lesions in pathogenesis and progression, and their use in diagnosis and monitoring response to therapy. The current or potential role of specific abnormalities as novel therapeutic targets is also discussed. There is also a full colour section containing original FISH, microarrays and immunostaining images.

  • 66500lei 640.00 lei

     When a biological drug patent expires, alternative biosimilar products are developed. The development of biosimilar products is complicated and involves numerous considerations and steps. The assessment of biosimilarity and interchangeability is also complicated and difficult.Biosimilar Drug Product Development presents current issues for the development of biosimilars and gives detailed reviews of its various stages and contributing factors as well as relevant regulatory pathways and pre- and post-approval issues.

  • Leukaemia Diagnosis, 5th Edition
    La comanda in aproximativ 4 saptamani
    75000lei 700.00 lei

    From the bestselling author, Barbara J. Bain, the new edition of this practical reference on the principles of leukaemia diagnosis and classification has been fully updated, and incorporates the recently revised WHO classification.

    Leukaemias are a very heterogeneous group of diseases, which differ from each other in aetiology, pathogenesis, prognosis and responsiveness to treatment. Accurate diagnosis and classification are vital for the identification of specific biological entities and underpin scientific advances in this field. The detailed characterization of haematological neoplasms is also essential for the optimal management of individual patients.

    In this user-friendly guide, Professor Bain illustrates and explains how these many laboratory techniques are used for the diagnosis and classification of leukaemia and related disorders. Leukaemia Diagnosis, Fifth Edition will be highly valuable to trainee haematologists and laboratory scientists in haematology and related disciplines, and will also prove a useful reference source and teaching aid for those who already have expertise in this field. In addition, cytogeneticists and molecular geneticists will find that this book enhances their understanding of the relationship of their disciplines to the diagnosis, classification and monitoring of leukaemia and related disorders.

    Essential reading for every haematologist and haematopathologist, Leukaemia Diagnosis, Fifth Edition features

    • Over 300 high quality full colour digital images of abnormal cells in leukaemia and lymphoma supplemented by histological, cytogenetic and immunophenotyping images
    • Recent information on cytogenetic and molecular genetic abnormalities in leukaemia
    • Updated information on the characteristic immunophenotypic characteristics of different categories of leukaemia

  • 89300lei 780.00 lei

    With authoritative coverage of rare and common hemostatic disorders, Consultative Hemostasis and Thrombosis, 4th Edition, keeps you both up to date with all that?s new in this fast-moving field as well as reviewing background and development and citing pertinent classical literature. Broad differential diagnoses are provided, underscoring the editors? position that correct treatment begins with correct diagnosis. This trusted resource by Drs. Craig S. Kitchens, Craig M. Kessler, Barbara A. Konkle, Michael B. Streiff, and David A. Garcia is designed for rapid reference and critical decision making at the point of care. Features: ? Emphasizes real-world problems and solutions, with quick access to concise descriptions of each condition, associated symptoms, laboratory findings, differential diagnosis, and treatment. ? Features a user-friendly design, full-color format, abundant laboratory protocols, and at-a-glance tables and charts throughout. New To This Edition: ? Provides thorough updates on core information on hemostasis and thrombosis, including deep venous thrombosis (DVT), pulmonary embolisms, hypercoagulability, thrombocytopenia, von Willenbrand disease, and more. ? Covers new treatment information on hemophilia A and B. ? Contains new chapters on hereditary hemorrhagic telangiectasia, hemolytic uremic syndrome, and paroxymal nocturnal hemoglobinuria. ? Two new editors, Dr. Michael B. Streiff and Dr. David A. Garcia, offer fresh perspectives and valuable experience. ? Expert Consult? eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

  • 86600lei 780.00 lei

    This authoritative new book provides a comprehensive overview of diagnostic and therapeutic strategies in hematopoietic cell transplantation, explaining key concepts, successes, controversies and challenges. The authors and editors discuss current and future strategies for major challenges, such as graft-versus-host-disease, including new prophylaxis and treatments. They also discuss long-term complications, such as second malignancies and cardiovascular complications. Chapters are written by leading world experts, carefully edited to achieve a uniform and accessible writing style. Each chapter includes evidence-based explanations and state-of-the-art solutions, providing the reader

  • 786.00 lei

     

    • A clinically oriented, compact, and up-to-date overview on all aspects of infections in hematology patients
    • Identifies the typical pathogens to be considered in different subgroups of patients
    • Presents clinical, imaging and laboratory-based diagnostic techniques and discusses the therapeutic strategies appropriate to different situations
    • Considers various prophylactic strategies

    About this book

    Infections are among the most frequent complications in patients with hematological malignancies and in those undergoing high-dose chemotherapy and autologous hematopoietic stem cell transplantation. A profound knowledge on the epidemiology, diagnostic approaches, treatment modalities and prophylactic strategies is essential for the clinical management of these complications in patients who are often severely immunocompromised owing to their underlying diseases and in particular, the intensive myelosuppressive chemo and immunotherapy. This textbook provides a clinically oriented, compact and up-to-date overview on infections in hematology patients and their management. The typical pathogens to be considered in different subgroups of patients are identified and further aspects of the microbiological background are explored.

    Clinical, imaging, and laboratory-based diagnostic techniques are discussed and therapeutic strategies appropriate to different situations are then presented, with due attention to the pitfalls, toxicities and interactions that can arise during antimicrobial treatment. Strategies to prevent infection are also outlined, encompassing antimicrobial prophylaxis, isolation procedures, hospital hygiene, protective immunization and the use of hematopoietic growth factors.

    Reviews

    “This is a comprehensive review of the risk factors, microbiology, prophylaxis, and management of infections in patients with hematological malignancies. … The audience includes students, residents, and practitioners who care for patients with hematological malignancies, and the book targets this group well. … Physicians who care for patients with hematological malignancies need a book like this to give them a comprehensive overview of the support and management of infections in these patients.” (Joseph C. Alvarnas, Doody's Book Reviews, May, 2015)

     

    Table of contents (18 chapters)

     

    ·         Infections in Patients with Acute Leukemia

    Rolston, Kenneth V. I.

    Pages 3-23

    ·         Infections in Patients with Malignant Lymphomas

    Rolston, Kenneth V. I.

    Pages 25-37

    ·         Consequences from Specific Treatment Modalities

    Maschmeyer, Georg

    Pages 39-47

    ·         Infections After High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation

    Nucci, Marcio (et al.)

    Pages 49-61

    ·         Microbiological Background

    Akova, Murat

    Pages 63-87

    ·         The Diagnostic Approach to the Febrile Neutropenic Patient: Clinical Considerations

    Bow, Eric J.

    Pages 91-111

    ·         Diagnostic Radiology in Hematological Patients with Febrile Neutropenia

    Heussel, Claus Peter

    Pages 113-135

    ·         Risk Stratification in Febrile Neutropenic Patients

    Paesmans, Marianne

    Pages 137-152

    ·         Fever of Unknown Origin: Treatment According to Risk Assessment

    Maschmeyer, Georg

    Pages 155-163

    ·         Pulmonary Complications

    Maschmeyer, Georg

    Pages 165-185

    ·         Vascular Catheter-Related Infections

    Dababneh, Luma (et al.)

    Pages 187-195

    ·         Gastrointestinal Complications

    Blijlevens, Nicole M. A.

    Pages 197-210

    ·         Central Nervous System Infections

    Schmidt-Hieber, Martin

    Pages 211-226

    ·         Antibacterial Agents

    Kern, Winfried V.

    Pages 229-258

    ·         Antifungal Agents

    Thompson, George R. (et al.)

    Pages 259-272

    ·         Antimicrobial Prophylaxis in Hematology

    Girmenia, Corrado (et al.)

    Pages 275-296

    ·         Infection Control and Hospital Epidemiology in Hematology Units

    Weisser, Maja (et al.)

    Pages 297-313

    ·         Myeloid Growth Factors

    Link, Hartmut

    Pages 315-324

  • Molecular Hematology
    La comanda in aproximativ 4 saptamani
    94000lei 795.00 lei

     

    DESCRIPTION

    The new and fully-revised volume of hematologic molecular biology for practicing and trainee hematologists

    Molecular Hematology is a comprehensive resource for hematologists to increase their understanding of the molecular basis of various blood diseases, their pathogeneses, and current and emerging molecular research and therapies. The impact of molecular research on the field of hematology is significant—molecular techniques are continuing to play a central role in in the diagnosis and treatment of blood diseases. Molecular characterization of genes and proteins has increased our comprehension of the causes of hematological diseases and led to the development of new drug therapies and recombinant proteins.

    Now in its fourth edition, Molecular Hematology has been thoroughly revised and updated to reflect current advances in molecular research. Chapters introduce and summarize specific disorders, such as hemophilia, anemia, and multiple myeloma, and illustrate the impact of molecular research on their diagnoses and treatments. Contributions written by respected clinicians and researchers offer accessible coverage of topics including lymphoma genetics, molecular coagulation and thrombophilia, platelet disorders, pharmacogenomics, and many others.

    ·         Demonstrates the clinical relevance of molecular biology in hematology

    ·         Provides overviews of recent advances in cancer-cell biology, with an emphasis on leukemia and lymphoma

    ·         Offers new and updated chapters written by an international team of experts in the field

    ·         Presents new full-color charts, graphs, and illustrations

    ·         Includes access to a Wiley Companion Digital Edition providing search across the book, downloadable illustrations and notation tools

    Molecular Hematology is an essential volume for both trainee and practicing hematologists and oncologists, molecular biologists, and research scientists working in the field of hematology.

    TABLE OF CONTENTS

    Contributors ix

    Preface to the fourth edition xiii

    Further reading xv

    Acknowledgments xvi

    1 Beginnings: the molecular pathology of hemoglobin 1
    David Weatherall

    2 Stem cells 21
    David T. Scadden

    3 The genetics of acute myeloid leukemias 37
    Amy M. Trottier & Carolyn J. Owen

    4 Molecular diagnostics and risk assessment in myeloid malignancies 49
    Christian Scharenberg & Torsten Haferlach

    5 Molecular basis of acute lymphoblastic leukemia 59
    Bela Patel & Fiona Fernando

    6 Chronic myeloid leukemia 71
    Hagop Kantarjian, Jorge Cortes, Elias Jabbour & Susan O’Brien

    7 Myeloproliferative neoplasms 87
    Jyoti Nangalia, Anthony J. Bench, Anthony R. Green & Anna L. Godfrey

    8 Lymphoma genetics 101
    Jennifer L. Crombie, Anthony Letai & John G. Gribben

    9 The molecular biology of chronic lymphocytic leukemia 111
    John G. Gribben

    10 The molecular biology of multiple myeloma 121
    Wee Joo Chng & P. Leif Bergsagel

    11 The molecular basis of bone marrow failure syndromes and red cell enzymopathies 131
    Deena Iskander, Lucio Luzzatto & Anastasios Karadimitris

    12 Anemia of chronic disease 155
    Tomas Ganz

    13 The molecular basis of iron metabolism 161
    Nancy C. Andrews & Tomas Ganz

    14 Hemoglobinopathies due to structural mutations 173
    D. Mark Layton & Steven Okoli

    15 Molecular pathogenesis of malaria 193
    David J. Roberts, Arnab Pain & Chetan E. Chitnis

    16 Molecular coagulation and thrombophilia 207
    Björn Dahlbäck & Andreas Hillarp

    17 The molecular basis of hemophilia 221
    Daniel P. Hart & Paul L.F. Giangrande

    18 The molecular basis of von Willebrand disease 235
    Luciano Baronciani

    19 Platelet disorders 251
    Kenneth J. Clemetson

    20 The molecular basis of blood cell alloantigens 267
    Cristina Navarrete, Louise Tilley, Winnie Chong & Colin J. Brown

    21 Functions of blood group antigens 285
    Jonathan S. Stamler & Marilyn J. Telen

    22 Autoimmune hematological disorders 297
    Drew Provan & John W. Semple

    23 Molecular therapeutics in hematology: gene therapy 319
    William M. McKillop & Jeffrey A. Medin

    24 Pharmacogenomics 339
    Leo Kager & William E. Evans

    25 History and development of molecular biology 353
    Paul Moss

    26 Cancer stem cells 363
    Sara Ali & Dominique Bonnet

    27 Molecular basis of transplantation 373
    Francesco Dazzi & Antonio Galleu

    Index 389

     

     

  • 90000lei 800.00 lei

    ​This book is an up-to-date reference on all aspects of anticoagulation and hemostasis in neurosurgery.  After an opening section on basic principles and drug classes in current use, detailed consideration is given to coagulation issues relevant to all patients, not just neurosurgical ones. The coverage includes, for example, deep vein thrombosis, pulmonary embolism, and disseminated intravascular coagulation. A variety of important issues specific to neurosurgical practice are then addressed, and a summary of current guidelines and best practices is provided. By bringing together the latest knowledge from across the discipline, this book will serve as a sound basis for informed decision making in surgical practice. It will be of daily value for neurosurgeons and trainees worldwide and will also be of interest to emergency room physicians, surgeons in general, critical care physicians, neurologists, and hospital medicine specialists.

  • 845.00 lei

    Features

    • Histological images and their quantitative examination by cytometry presented side by side
    • Over 350 high-quality images
    • Based on WHO classification of hematopoietic tumors
    • Detailed and up-to-date criteria for diagnosis
    • Systematic approach including basic cases and complicated problem areas

    Summary

    This third edition is the product of the author’s 25 years of experience with flow cytometry; although it covers the wide spectrum of hematopoietic tumors, the focus remains on most important clinical diagnoses, such as acute promyelocytic leukemia, identification of blasts, identification of clonal B-cell population, differentiating mature versus immature T-cell proliferations, deferential diagnosis between hematogones and B-ALL or distinction between chronic and acute monocytic proliferations. All hematopathologists and neoplastic hematologists will find this an important resource for keeping up to date with developments in clinical practice.

  • 845.00 lei

    Hematologic malignancies were the first human cancers to be studied in depth at the molecular level, and recent years have seen important advances in treatment. This comprehensive reference book covers the full range of hematologic malignancies, including all subtypes of leukemias, lymphomas, and plasma cell dyscrasias. Authored by internationally known experts, each chapter emphasizes diagnostic work-up, staging, and therapeutic approaches. Up-to-date hematopathology, treatment, and outcomes data are presented in a way which is directly applicable to patient care. Highly illustrated with color images, graphs, flowcharts and treatment algorithms, the book is perfect for quick clinical reference as well as providing detailed reference lists for further study. With its authoritative and practical focus and visually stimulating presentation, this is a key text for hematology and oncology fellows, physicians, oncology nurses, physician assistants and other healthcare workers in the field of oncology. Covers epidemiology, etiology, risk-factors, clinical presentation, diagnosis, staging and treatment strategies for each disease subset Color images, graphs, flowcharts, algorithms and tables enhance the presentation and clinical utility of the text Extensive reference lists enable further reading and study

  • 98100lei 850.00 lei

    Provides coverage of the pathogenesis, clinical, morphologic, molecular and investigational aspects of a full range of blood disorders seen in daily practice The revised fifth edition of this renowned atlas presents readers with a comprehensive, visual guide to clinical hematology, featuring 2700 full-color photographs and figures depicting the spectrum of hematological diseases. Ranging from photographs of the clinical manifestations and key microscopic findings to diagrams of the molecular aspects of these diseases, the book provides up-to-date information of the blood diseases that clinicians encounter every day. Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease offers the reader an understanding of normal cell machinery, and of the molecular basis for such processes as DNA and cell replication, RNA species, trafficking and splicing, protein synthesis, transcription factors, growth factor signal transduction, epigenetics, cell differentiation, autophagy, and apoptosis. The text goes on to explore how these processes are disturbed in the various diseases of the bone marrow, blood, and lymphoid systems. Helps solve difficult diagnostic challenges and covers complex principles using highly illustrative, full-color images Explores all aspects of benign and malignant hematology, including blood transfusion and coagulation with extensive coverage of the pathogenesis of common clinical entities Provides a quick and easy reference of key diagnostic issues in a comprehensive yet concise format Includes and illustrates the WHO Classification of Hematologic Malignancies Illustrates the new knowledge of the molecular basis of inherited and acquired blood diseases Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease is the must-have resource for both trainee and practising hematologists, and for every department of hematology.

  • Chronic Lymphocytic Leukemia
    La comanda in aproximativ 4 saptamani
    1,12400lei 930.00 lei

    Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. For a long time th

  • 1,16300lei 980.00 lei

    First published in 2006, the bestselling Wintrobe's Atlas of Clinical Hematologyhas now been comprehensively updated by a brand-new editorial team to bring you state-of-the-art pictorial coverage of the complete range of hematologic conditions. Thousands of meticulous, full-color images capture the characteristic appearance of each pathologic entity, and concise descriptions point out features of diagnostic importance. The result is a peerless reference to facilitate confident diagnosis in hematology.

    Features:

    Access the latest knowledge in the field with more than 30% new or updated content - including expanded coverage of acute lymphoblastic leukemia (ALL); revised diagnostic criteria for fluorescent in situ hybridization (FISH); enhanced information on flow cytometry; new coverage of genetic screens, circulating DNA analysis, RT-PCR, exosome analysis, and evaluation of epigenetic abnormalities; completely new chapters on hemostasis and platelets as well as on plasma cell disorders and on benign diseases of leukocytes, spleen, and immunoglobins; and much more.Vividly visualize the presentation of every hematologic disorder thanks to thousands of crisp, full-color images, hundreds of them new to this edition.Locate the information you need more easily through a new, highly templated format that expedites navigation, as well as a new index of figures by disorder.Easily find additional in-depth answers inside Wintrobe's Clinical Hematology, the best-selling comprehensive reference in the field, since this Atlas now features a parallel organization.Your book purchase includes a complimentary download of the enhanced eBook for iOS, Android, PC & Mac. Take advantage of these practical features that will improve your eBook experience: The ability to download the eBook on multiple devices at one time - providing a seamless reading experience online or offlinePowerful search tools and smart navigation cross-links that allow you to search within this book, or across your entire library of VitalSource eBooksMultiple viewing options that enable you to scale images and text to any size without losing page clarity as well as responsive designThe ability to highlight text and add notes with one click

  • 1,35000lei 1150.00 lei


    Perfect for radiation oncology physicians and residents needing a multidisciplinary, treatment-focused resource, this updated edition continues to provide the latest knowledge in this consistently growing field. Not only will you broaden your understanding of the basic biology of disease processes, you'll also access updated treatment algorithms, information on techniques, and state-of-the-art modalities. The consistent and concise format provides just the right amount of information, making Clinical Radiation Oncology a welcome resource for use by the entire radiation oncology team.
    Features: • Content is templated and divided into three sections -- Scientific Foundations of Radiation Oncology, Techniques and Modalities, and Disease Sites - for quick access to information.
    • Disease Sites chapters summarize the most important issues on the opening page and include a full-color format, liberal use of tables and figures, a closing section with a discussion of controversies and problems, and a treatment algorithm that reflects the treatment approach of the authors.
    • Chapters have been edited for scientific accuracy, organization, format, and adequacy of outcome data (such as disease control, survival, and treatment tolerance).
    • Allows you to examine the therapeutic management of specific disease sites based on single-modality and combined-modality approaches.
    • Features an emphasis on providing workup and treatment algorithms for each major disease process, as well as the coverage of molecular biology and its relevance to individual diseases.
    New To This Edition:

    • Two new chapters provide an increased emphasis on stereotactic radiosurgery (SRS) and stereotactic body irradiation (SBRT).
    • New Associate Editor, Dr. Andrea Ng, offers her unique perspectives to the Lymphoma and Hematologic Malignancies section.
    • Key Points are summarized at the beginning of each disease-site chapter, mirroring the template headings and highlighting essential information and outcomes.
    • Treatment algorithms and techniques, together with discussions of controversies and problems, reflect the treatment approaches employed by the authors.
    • Disease Site Overviews allow each section editor to give a unique perspective on important issues, while online updates to Disease Site chapters ensure your knowledge is current.
    • Disease Site chapters feature updated information on disease management and outcomes.
    • Four videos accessible on Expert Consult include Intraoperative Irradiation, Prostate Brachytherapy, Penile Brachytherapy, and Ocular Melanoma.
    • Thirty all-new anatomy drawings increase your visual understanding.
    • Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

  • Williams Hematology, 9E
    La comanda in aproximativ 4 saptamani
    1165.00 lei

    Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields. The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis. Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.

  • 1,46800lei 1365.00 lei

    Get the expert guidance you need to offer your patients the best possible outcomes with Hematology: Basic Principles and Practice, 7th Edition. This thoroughly up-to-date text contains both unparalleled scientific content and must-know clinical guidance, so you can enhance your problem-solving skills and make optimal use of the newest diagnostic techniques and therapeutic options in this fast-changing field.

    New to this edition
    • Delivers state-of-the-art information and guidance from editors and global contributors who are at the forefront of their respective subspecialty areas.
    •  

    • Features sweeping content updates throughout, including basic science research which serves as a foundation for modern hematology, recent advances in stem cell transplantation, clinical advances in the treatment of each of the hematologic malignancies, immune checkpoint inhibitors, molecular diagnostics, transfusion medicine, and much more.
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    • Includes several new chapters including Epigenetics and Epigenomics, Stem Cell Model of Hematologic Diseases, Multiple Myeloma, IND Enabling Processes for Cell-Based Therapies, and Immune Checkpoint Blockade in Hematologic Malignancies.
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    • New Virtual Microscope with the ability to zoom in on high-quality digital hematopathology slides and frequent content updates accessible anywhere, any time on your favorite digital device.
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    • Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.

  • 1,87400lei 1500.00 lei

     

    Description:

    Written by the leading names in pediatric oncology and hematology, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color, two-volume set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children.

    Features:

    Form a definitive diagnosis and create the best treatment plans possible with comprehensive coverage of all pediatric cancers, including less-common tumors, as well as all hematologic disorders, including newly recognized ones.

    Develop a thorough, understanding of the underlying science of diseases through summaries of relevant pathophysiology balanced with clear, practical clinical guidance. Nathan and Oski’s is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children.

    Quickly and effortlessly access the key information you need with the help of a consistent organization from chapter to chapter and from volume to volume.

    New To This Edition:

    Stay at the forefront of your field thanks to new and revised chapters covering topics such as paroxysmal nocturnal hemoglobinuria, lysosomal storage diseases, childhood genetic predisposition to cancer, and oncology informatics.

    Learn about the latest breakthroughs in diagnosis and management, making this the most complete guide in pediatric hematology and oncology.

    Discover the latest in focused molecularly targeted therapies derived from the exponential growth of knowledge about basic biology and genetics underlying the field.

    Rely on it anytime, anywhere! Access the full text, images, and more at Expert Consult.

    Table Of Contents:

    Section I Neonatal Hematology

    1. Anatomy and Physiology of Hematopoiesis

    2. The Neonatal Erythrocyte and Its Disorders

    3. Immune Hemolytic Disease

    4. Neonatal Jaundice and Disorders of Bilirubin Metabolism

    5. Hemostasis in the Newborn and Infant

    Section II Bone Marrow Failure

    6. Acquired Aplastic Anemia and Pure Red Cell Aplasia

    7. Inherited Bone Marrow Failure Syndromes

    8. Principles of Bone Marrow and Stem Cell Transplantation

    Section III Disorders of Erythrocyte Production

    9. Diagnostic Approach to the Anemic Patient

    10. Megaloblastic Anemia

    11. Disorders of Iron and Copper Metabolism, Sideroblastic Anemias and Lead Toxicity

    12. Porphyrias

    Section IV Hemolytic Anemias

    13. Autoimmune Hemolytic Anemia

    14. Paroxysmal Nocturnal Hemoglobinuria

    15. Red Cell Membrane

    16. Disorders of the Red Cell Membrane

    17. Pyruvate Kinase Deficiency and Disorders of Glycolysis

    18. Glucose-6-Phosphate Dehydrogenase Deficiency

    19. Normal and Abnormal Hemoglobins

    Section V Disorders of Hemoglobin

    20. Sickle Cell Disease

    21. Thalassemias

    Section VI Phagocyte System

    22. Phagocyte System and Disorders of Granulopoiesis and Granulocyte Function

    Section VII Immune System

    23. Immune Response

    24. Primary Immunodeficiency Diseases

    Section VIII Storage Diseases

    25. Lysosomal Storage Diseases

    Section IX Hemostasis

    26. Platelets and the Vessel Wall

    27. Blood Coagulation

    28. Molecular Basis of Fibrinolysis

    29. Approach to the Child with a Suspected Bleeding Disorder

    30. Inherited Platelet Disorders

    31. Hemophilia and von Willebrand Disease

    32. Rare Hereditary Coagulation Factor Abnormalities

    33. Inherited Disorders of Thrombosis and Fibrinolysis

    34. Acquired Platelet Defects

    35. Acquired Disorders of Hemostasis

    Section X Supportive Therapy

    36. Transfusion Medicine

    Section XI Hematologic Manifestations of Systemic Diseases

    37. Hematological Manifestations of Systemic Diseases

    38. Hematology Manifestations of Systemic Diseases in Children of the Developing World

    Section XII Biology of Cancer

    39. Origins and Evolution of Pediatric Cancer

    40. Epidemiology of Leukemia in Childhood

    41. Informatics

    42. Genetic Predisposition to Cancer

    43. Genetic and Epigenetics of Childhood Cancers

    44. Targeted Therapies in Oncology

    45. Cytogenetic and Molecular Pathology of Pediatric Cancer 

    Section XIII Pediatric Cancer Therapeutics

    46. Cancer Chemotherapy for Pediatric Patients

    47. Immunotherapy of Cancer

    48. Pediatric Radiation Oncology

    48. Pediatric Surgical Oncology 

    Section XIV Hematologic Malignancy

    50. Acute Lymphoblastic Leukemia 

    51. Pediatric Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease

    52. Infant Leukemias

    53. Pediatric Lymphoma

    Section XV Solid Tumors

    54. Neuroblastoma

    55. Pediatric Renal Tumors

    56. Retinoblastoma

    57. Tumors of the Brain and Spinal Cord 

    58. Hepatoblastoma and Other Liver Tumors in Children

    59. Rhabdomyosarcoma

    60. Nonrhabdomyosarcoma Soft Tissue Sarcomas and Other Soft Tissue Tumors 

    61. Ewing Sarcoma

    62. Osteosarcoma

    63. Pediatric Germ Cell Tumors

    64. Histiocytoses

    65. Rare Tumors of Childhood

    66. Imaging in the Evaluation and Management of Childhood Cancer

    Section XVI Supportive Care

    67. Infectious Disease in the Pediatric Cancer Patient 

    68. Oncologic Emergencies

    69. Nursing Care of Patients with Childhood Cancer 

    70. Palliative Care in Pediatric Oncology

    71. Symptom Management in Children with Cancer

    72. Childhood Cancer Survivorship

    73. Psychosocial Care of the Child and Family

    74. Ethical Considerations in Pediatric Oncology Clinical Trials 

    Appendices: Reference Values in Infancy and Childhood

       

     

  • 1,93400lei 1550.00 lei

    This extensive title, which combines scientific principles with up-to-date clinical procedures, has been thoroughly updated for the fourteenth edition. You?ll find in-depth material on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. ? Combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders in one volume. ? Access the latest knowledge in genetics and genomics ? eBook features 300 online self-assessment questions for reviewing material and preparing for Board exams. ? Packed with more than 1,500 tables and figures. Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! ? Read directly on your preferred device(s), such as computer, tablet, or smartphone. ? Easily convert to audiobook, powering your content with natural language text-to-speech. ? Adapt for unique reading needs, supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more.

  • 1950.00 lei

    Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. · Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research · Combines the knowledge and expertise of over 170 international specialists across 106 chapters · Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance ·Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more

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