The Blood-Brain Barrier in Health and Disease, Volume Two: Pathophysiology and Pathology

Description:

Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Abnormalities of the blood-brain barrier are increasingly recognized as a key component in the pathogenesis of a range of primary diseases of the brain and the secondary involvement of the brain from pathological processes in other organs. In The Blood-Brain Barrier in Health and Disease, Volume 2, international experts present comprehensive reviews and research accounts on blood-brain barrier dysfunction in infectious and inflammatory diseases, cerebrovascular diseases, stroke, trauma, vitamin deficiency, exposure to neurotoxicants, primary and metastatic brain tumors, and neurodegenerative diseases. This book is intended to serve as a guide and reference to basic and advanced information for researchers, students, and clinicians interested in this fast-expanding field and stimulate further research well into the future.

Table of Contents:

Preface to Volume 2

List of Contributors

1. Blood-Brain Barrier Disruption in Multiple Sclerosis

2. Portals of Viral Entry into the Central Nervous System

3. Blood Brain Barrier (BBB) Dysfunction in HIV Infection

4. The Brain Microvasculature in Cerebral Malaria

5. The Blood-Brain Barrier in Bacterial Infections of the Central Nervous System

6. Blood-Brain Barrier in Fungal Infections of the Central Nervous System

7. Blood-Brain Barrier Changes in Traumatic Brain Injury

8. Alterations of the Blood-Brain Barrier in Post-Traumatic Epilepsy

9. Functional and Molecular Mechanisms of Hypertensive Brain Damage

10. Blood Brain Barrier Protection in Stroke: Taming tPA

11. Radiation-Induced Blood-Brain Barrier Disruption

12. The Blood-Brain Barrier in Thiamine Defi ciency (Wernicke’s Encephalopathy)

13. The Blood-Brain-Barrier in Brain Tumors

14. Cerebral Amyloid Angiopathy: Clinicopathologic Features and Pathogenesis

15. Vascular Factors and the Blood Brain Barrier in Alzheimer’s Disease, Parkinson’s Disease and

16. Blood-Brain Barrier Damage in the Context of HIV Infection and Drug Abuse