Molecular Hematology

DESCRIPTION

The new and fully-revised volume of hematologic molecular biology for practicing and trainee hematologists

Molecular Hematology is a comprehensive resource for hematologists to increase their understanding of the molecular basis of various blood diseases, their pathogeneses, and current and emerging molecular research and therapies. The impact of molecular research on the field of hematology is significant—molecular techniques are continuing to play a central role in in the diagnosis and treatment of blood diseases. Molecular characterization of genes and proteins has increased our comprehension of the causes of hematological diseases and led to the development of new drug therapies and recombinant proteins.

Now in its fourth edition, Molecular Hematology has been thoroughly revised and updated to reflect current advances in molecular research. Chapters introduce and summarize specific disorders, such as hemophilia, anemia, and multiple myeloma, and illustrate the impact of molecular research on their diagnoses and treatments. Contributions written by respected clinicians and researchers offer accessible coverage of topics including lymphoma genetics, molecular coagulation and thrombophilia, platelet disorders, pharmacogenomics, and many others.

·         Demonstrates the clinical relevance of molecular biology in hematology

·         Provides overviews of recent advances in cancer-cell biology, with an emphasis on leukemia and lymphoma

·         Offers new and updated chapters written by an international team of experts in the field

·         Presents new full-color charts, graphs, and illustrations

·         Includes access to a Wiley Companion Digital Edition providing search across the book, downloadable illustrations and notation tools

Molecular Hematology is an essential volume for both trainee and practicing hematologists and oncologists, molecular biologists, and research scientists working in the field of hematology.

TABLE OF CONTENTS

Contributors ix

Preface to the fourth edition xiii

Further reading xv

Acknowledgments xvi

1 Beginnings: the molecular pathology of hemoglobin 1
David Weatherall

2 Stem cells 21
David T. Scadden

3 The genetics of acute myeloid leukemias 37
Amy M. Trottier & Carolyn J. Owen

4 Molecular diagnostics and risk assessment in myeloid malignancies 49
Christian Scharenberg & Torsten Haferlach

5 Molecular basis of acute lymphoblastic leukemia 59
Bela Patel & Fiona Fernando

6 Chronic myeloid leukemia 71
Hagop Kantarjian, Jorge Cortes, Elias Jabbour & Susan O’Brien

7 Myeloproliferative neoplasms 87
Jyoti Nangalia, Anthony J. Bench, Anthony R. Green & Anna L. Godfrey

8 Lymphoma genetics 101
Jennifer L. Crombie, Anthony Letai & John G. Gribben

9 The molecular biology of chronic lymphocytic leukemia 111
John G. Gribben

10 The molecular biology of multiple myeloma 121
Wee Joo Chng & P. Leif Bergsagel

11 The molecular basis of bone marrow failure syndromes and red cell enzymopathies 131
Deena Iskander, Lucio Luzzatto & Anastasios Karadimitris

12 Anemia of chronic disease 155
Tomas Ganz

13 The molecular basis of iron metabolism 161
Nancy C. Andrews & Tomas Ganz

14 Hemoglobinopathies due to structural mutations 173
D. Mark Layton & Steven Okoli

15 Molecular pathogenesis of malaria 193
David J. Roberts, Arnab Pain & Chetan E. Chitnis

16 Molecular coagulation and thrombophilia 207
Björn Dahlbäck & Andreas Hillarp

17 The molecular basis of hemophilia 221
Daniel P. Hart & Paul L.F. Giangrande

18 The molecular basis of von Willebrand disease 235
Luciano Baronciani

19 Platelet disorders 251
Kenneth J. Clemetson

20 The molecular basis of blood cell alloantigens 267
Cristina Navarrete, Louise Tilley, Winnie Chong & Colin J. Brown

21 Functions of blood group antigens 285
Jonathan S. Stamler & Marilyn J. Telen

22 Autoimmune hematological disorders 297
Drew Provan & John W. Semple

23 Molecular therapeutics in hematology: gene therapy 319
William M. McKillop & Jeffrey A. Medin

24 Pharmacogenomics 339
Leo Kager & William E. Evans

25 History and development of molecular biology 353
Paul Moss

26 Cancer stem cells 363
Sara Ali & Dominique Bonnet

27 Molecular basis of transplantation 373
Francesco Dazzi & Antonio Galleu

Index 389