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  • 129.00 lei

    This is a revision book to help pharmacist students prepare for the pre-registration exam of the Royal Pharmaceutical Society of Great Britain (RPSGB) and other similar exams. It consists of over 400 multiple choice questions (MCQs), with explanatory answ

  • 150.00 lei

    Oferta speciala! 185 lei 150 lei

    Lippincott's Illustrated Reviews: Pharmacology, Fifth Edition enables rapid review and assimilation of complex information and focuses on the essentials of medical pharmacology. Clear, sequential pictures present mechanisms of action and actually show, rather than tell, students how drugs work.

  • 160.00 lei

    Lippincott Illustrated Reviews: Pharmacology, Sixth Edition, is the updated, enhanced version of the student-favorite resource for essentials of medical pharmacology. The first-and-best resource, the Lippincott Illustrated Reviews series features clear, effective writing and hundreds of illustrations for ideal rapid review and the assimilation of complex information. Clear, sequential images present mechanisms of action and focus on showing rather than telling students how drugs work. New edition features:

    • All NEW chapters on Drugs of Abuse, Drugs for Obesity, Antihistamines, Drugs for Urologic Disorders, Drugs for Hematopoietic Disorders, Drugs for Dermatological Disorders, and Drugs for Bone Disorders
    • Over 380 study questions!
    • Nearly 600 annotated, full-color illustrations visually explain complex processes!
    • Outline format ideal for concise review and foundational learning

  • 175.00 lei

    Now fully updated for a second edition, the Oxford Handbook of Clinical Pharmacy remains the indispensible guide to clinical pharmacy, providing all the information needed for practising and student pharmacists. Presenting handy practical guidance in a quick-reference, bullet-point format, it will supply the knowledge and confidence you need to provide a clinical pharmacy service. The handbook includes information on controlled drugs, adverse drug reactions, interactions, communication skills, and confidentiality. It also features chapters on adherence, anaphylaxis, clinical trials, herbal medicines, patient management, pharmaceutical calculations, research, policy, and therapy related issues. Palliative care sections have been expanded to include symptom management and end-of-life pathways. Other new sections such as pharmacogenetics, thyroid disorders, and domiciliary oxygen therapy have been included. Complementing the current British National Formulary guidelines, the handbook gives prescribing points and linked concepts of relevance to clinical pharmacists. The content is evidence-based and contains a wealth of information from the authors' many years of clinical pharmacy experience.

  • Pharmacology Flash Cards
    La comanda in aproximativ 4 saptamani
    20200lei 182.00 lei

    Completely revised to correlate to Brenner and Stevens' Pharmacology, 5th Edition, these beautifully illustrated flash cards cover the essential pharmacology concepts you need to know for course exams and the USMLE Step 1. Perfect for individual or group study, they're ideal for quickly mastering must-know information in this challenging field. Full-color cards cover hundreds of the most commonly used drugs, including name and pronunciation, drug class, mechanism of action (MOA), clinical use, special considerations, adverse effects, interactions, and similar drugs (generic and trade names). Provides "need to know" information on every card and points you directly to where more detailed information can be found in the Brenner and Stevens' textbook. Content can be easily customized with your own notes or highlighting. Student ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references to produce a more rounded learning experience.

  • 190.00 lei

    A full-color manual derived from Goodman & Gilman's The Pharmacological Basis of Therapeutics. Goodman & Gilman's The Manual of Pharmacology and Therapeutics offers concise, authoritative coverage of class-specific and disease-specific drugs, organized primarily by organ/system. Derived from Goodman & Gilman's Pharmacological Basis of Therapeutics, Twelfth Edition and further updated, this streamlined text focuses on the principles of medical pharmacology and drug therapy and delivers coverage of all major drug classes. More than a pocket drug guide, this powerful resource covers: General Principles; Neuropharmacology; Modulation of Cardiovascular, Pulmonary, and Renal Function; Inflammation, Immunomodulation, and Hematopoiesis; Hormones and Hormone Antagonists; Drugs Affecting Gastrointestinal Function; Chemotherapy of Microbial Diseases; Chemotherapy of Neoplastic Diseases; and Special Systems Pharmacology, including Environmental Toxicology. The text explains the physiology and pathophysiology of major organ systems and pathogens with respect to pharmacotherapy and the mechanisms of drug action. With a new full color design and numerous tables, charts, and illustrations that highlight, explain, and summarize important information, Goodman & Gilman's Manual of Pharmacology and Therapeutics is essential wherever knowledge of drug actions and interactions is required

  • 190.00 lei

    The most up-to-date, comprehensive, and authoritative pharmacology text in health medicine organized to reflect the syllabi in many pharmacology courses and in integrated curricula, Basic & Clinical Pharmacology, 13e covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. Selection of the subject matter and order of its presentation are based on the authors' many years experience in teaching this material to thousands of medical, pharmacy, dental, podiatry, nursing, and other health science students. To be as clinically relevant as possible, the book includes sections that specifically address the clinical choice and use of drugs in patients and the monitoring of their effects, and case studies that introduce clinical problems in many chapters. Presented in full color and enhanced by more than three hundred illustrations, Basic & Clinical Pharmacology features numerous summary tables and diagrams that encapsulate important information. It explains everything students need to know about the science of pharmacology and its application to clinical practice. Includes 330 full-color illustrations, case studies, and chapter-ending summary tables. It is organized to reflect the syllabi of pharmacology courses Descriptions of important new drugs.

  • 205.00 lei

    Complementing the guidelines in the British National Formulary, the third edition of the Oxford Handbook of Clinical Pharmacy remains the indispensable guide to clinical pharmacy, providing all the information needed for practising and student pharmacists. It presents handy practical guidance in a quick-reference, bullet-point format to give the reader the knowledge and confidence needed to provide a clinical pharmacy service.

    Including key information on controlled drugs, adverse drug reactions, interactions, communication skills, and confidentiality, this extensively revised addition to the bestselling Oxford Handbook series is the fundamental pharmacy reference tool. It features chapters on adherence, anaphylaxis, clinical trials, herbal medicines, palliative care, patient management, pharmaceutical calculations, research, policy, and therapy related issues.

    Thoroughly revised and updated, the Oxford Handbook of Clinical Pharmacy includes brand new topics, including content on health coaching, residency and on-call, HIV and TB and mental health.

  • 220.00 lei

    The Fifth Edition of Luellmann's Color Atlas of Pharmacology has been extensively revised to include all recent advances and new drugs, and the illustrations have been optimized and updated. Each two-page spread presents concise text on the left complemented by detailed full-color illustrations on the right to help users quickly digest important facts and concepts.

    Color-coded sections provide readers with a helpful framework with which to approach the latest developments in pharmacology.

    • Part 1, General Pharmacology, explains basic aspects, such as drug absorption, distribution, and elimination, along with the molecular mechanisms of drug actions
    • Part 2, Systems Pharmacology, presents the different groups of drugs, emphasizing their functional and therapeutic aspects
    • Part 3, Therapy of Selected Diseases, provides all the relevant information regarding the pharmacological treatment of a large number of conditions

    Key features:

    • User-friendly format ideal for study and review, self-assessment, and quick reference
    • Completely revised and updated, with 174 color plates
    • New glossary of important and interesting pharmacological terms
    • Updated detailed drug indexes containing current information on drugs listed by both generic and brand names

    The Fifth Edition of Color Atlas of Pharmacology is an essential study guide and reference for every student, nurse, and practicing physician needing to keep up to date with recent advances in the field.

  • 220.00 lei

    The essential pharmacotherapy data you need for clinical practice and board preparation – in one carry-anywhere guide Pharmacotherapy Handbook provides the critical information you need to make drug therapy decisions for more than 140 diseases and disorders commonly encountered in a clinical setting. Featuring a convenient alphabetized presentation, this handy guide utilizes text, tables, figures, and treatment algorithms to make important drug data readily accessible and easily understood. Features: Consistent chapter organization includes: Disease state definition Concise review of relevant pathophysiology Clinical presentation Diagnosis Goals of treatment Treatment Monitoring Six appendices, including "Allergic and Pseudoallergic Drug Reactions" and "Geriatrics"

  • 224.00 lei

    What do we do if different studies appear to give different answers? When applying research to questions for individual patients or for health policy, one of the challenges is interpreting such apparently conflicting research. A systematic review is a method to systematically identify relevant research, appraise its quality, and synthesize the results. The last two decades have seen increasing interest and developments in methods for doing high quality systematic reviews. Part I of this book provides a clear introduction to the concepts of reviewing, and lucidly describes the difficulties and traps to avoid. A unique feature of the book is its description, in Part II, of the different methods needed for different types of health care questions: frequency of disease, prognosis, diagnosis, risk, and management. As well as illustrative examples, there are exercises for each of the sections. This is essential reading for those interested in synthesizing health care research.

  • 250.00 lei

    Catastrophes under anesthesia have focused attention on the interaction between drugs, including prescribed and non-prescribed medications, including interactions with vitamins, herbal preparations, traditional remedies, and food supplements. This book summarizes the adverse effects of a large range of drugs used in anesthesia.

  • 30000lei 260.00 lei

    Oferta speciala!!!  300 lei   260 lei

    For 25 years, Rang and Dale's Pharmacology has delivered the core basic and clinical science information required by students and healthcare practitioners worldwide. Authors H. P. Rang, J. M. Ritter, R. J. Flower, and G. Henderson have ensured that the 8th Edition of this easy-to-read, comprehensive text continues the tradition of excellence with new coverage of drugs affecting the skin and new components online at Student Consult. Get the essential pharmacology information you need from one authoritative source with an outstanding global reputation for excellence. Progress confidently through all relevant aspects of pharmacology, beginning with a molecular understanding of receptors and drug actions through clinical uses of key groups of drugs. Find important content quickly thanks to a color-coded layout that enables easy navigation and cross-referencing. Master difficult concepts with Key Points boxes, Clinical Uses boxes, and full-color illustrations throughout. Stay up to date with new information in the field, including an all-new chapter on drugs that affect the skin. Take advantage of new and unique features online, including 500+ chapter-specific multiple choice questions for immediate self-assessment. eBook version included!

     

  • 278.00 lei

    This spin-off from Stephen M. Stahl's new, completely revised, and fully updated sixth edition of the Prescriber's Guide covers the most important drugs in use today for treating depression. Now established as the indispensable formulary in psychopharmacology, easy to navigate and easy to use, the Prescriber's Guide combines evidence-based information with clinically informed guidance to support clinicians in making the most effective prescribing decisions for the good of their patients. Incorporating information on the newest indications, new formulations, new recommendations and new safety data, this edition continues to provide the essential practical support required by anyone prescribing in the field of mental health.

  • 31600lei 286.00 lei

    Designed to help you learn and retain key information in pharmacology, this foundational text takes you from course exams and the USMLE Step 1 right through to clinical practice. Brenner and Stevens' Pharmacology, 5th Edition, focuses on the essential principles you need to know, in a concise yet comprehensive manner that's easy to understand. Highly illustrated and formatted for quick reference, it's your go-to text for the must-know aspects of pharmacology you'll need for clinical problem solving and decision making. Teaches the fundamental aspects of pharmacology using full-color illustrations, detailed explanations, and a consistent format to present classification of drugs for each system/disease. Features useful tables, drug classifications boxes, case studies, and self-assessments in each chapter to help you review and prepare for course exams and Step 1. Student ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and animations, designed to produce a more rounded learning experience. You'll also find an additional glossary, chapter-by-chapter summaries and case studies, a full list of featured drugs, 150 USMLE-style questions, and more. Includes the latest pharmacologic mechanisms and applications with new and updated drug information throughout.

  • 420.00 lei

    Carbamazepine (CBZ) is a member of the iminostilbene family, and it possesses a carbonyl group that is essential for its antiepileptic activity. It has been demonstrated and is widely accepted that CBZ is effective in the control of epileptic crises; unfortunately, there is scattered information concerning whether CBZ can aid in the sleep disorders produced by these crises. Chapter One evaluates the effect of the administration of CBZ on the sleep patterns in a model of epilepsy induced by KA and its pharmacokinetic and pharmacodynamic correlation. Chapter Two discusses the use of carbamazepine in freediving. Carbamazepine produces the protective effect of hypoxia and prolongs latency for the development of convulsions and death. Chapter Three is a review of current reports on the presence of carbamazepine in the environment, complemented with a general overview of typical (usually low) efficiencies with which conventional wastewater treatment plants are capable of removing carbamazepine from domestic wastewaters. CBZ is hardly biodegraded (the removal efficiency is <10%) through the conventional activated sludge process and the white-rot fungus (WRF) is reported the only microorganism to degrade it efficiently. The final chapter aims to enhance the removal performance of WRF reactor toward CBZ under non-sterile conditions during long-term operation.

  • 46700lei 430.00 lei

    467 RON 430 RON

    Familiarly known as the "Orange Guide," this title is an essential reference work for all those involved in the manufacture or distribution of medicines in or for Europe. It is compiled by the UK drug regulatory body, the MHRA, and brings together the European and UK guidance documents and information on legislation relating to the manufacture and distribution of medicines for human use. It contains EU guidance on good manufacturing and good distribution practice along with relevant information on EU and UK legislation. This 2015 edition of Rules and Guidance for Pharmaceutical Manufacturers and Distributors (the Orange Guide) has been updated to incorporate changes made to Chapter 6 Quality Control of the detailed European Community guidelines on Good Manufacturing Practice (GMP) which came into operation on 1 October 2014 and the revised EU Guidelines on Good Distribution Practice.

  • 46200lei 430.00 lei

    With the range of psychotropic drugs expanding and the usages of existing medications diversifying, we are pleased to present this very latest edition of what has become the indispensable formulary in psychopharmacology. This new edition features seven new compounds as well as information about several new formulations of existing drugs. In addition, many important new indications are covered for existing drugs, as are updates to the profiles of the entire content and collection, including an expansion of the sections on long-acting injectable formulations of antipsychotics. With its easy-to-use, template-driven navigation system, The Prescriber's Guide combines evidence-based data with clinically informed advice to support everyone who is prescribing in the field of mental health.

    •  
    • Provides the most complete and up-to-date summary of the practical use of psychotropic drugs, including seven new drugs in this edition
    • Presented in a templated format, fully indexed and cross-referenced for ease of navigation
    • Written with the authority of evidence and the guidance of clinical wisdom

  • 440.00 lei

    Responding to the increased scrutiny of drug safety in recent years, Quantitative Evaluation of Safety in Drug Development: Design, Analysis and Reporting explains design, monitoring, analysis, and reporting issues for both clinical trials and observational studies in biopharmaceutical product development. It presents the latest statistical methods for drug safety assessment. The book’s three sections focus on study design, safety monitoring, and data evaluation/analysis. The book addresses key challenges across regulatory agencies, industry, and academia. It discusses quantitative approaches to safety evaluation and risk management in drug development, covering Bayesian methods, effective safety graphics, and risk-benefit evaluation. Written by a team of experienced leaders, this book brings the most advanced knowledge and statistical methods of drug safety to the statistical, clinical, and safety community. It shares best practices and stimulates further research and methodology development in the drug safety area.

  • Pediatric & Neonatal Dosage Handbook
    La comanda in aproximativ 4 saptamani
    51400lei 460.00 lei

    The Lexicomp Pediatric & Neonatal Dosage Handbook, 23rd edition, is a valuable point-of-care dosing resource designed to support medical professionals managing pediatric and neonatal patients.

    Benefits

    The Pediatric & Neonatal Dosing Handbook includes more than 1,000 drug monographs featuring concise fields of information specific to neonates and children. It follows a convenient, dictionary-like format, with drug products alphabetically organized and cross-referenced by U.S. and Canadian brand names.

    Clear, concise and relevant Lexicomp drug information is supplemented by an extensive Appendix of comparative charts, tables and supportive information, as well as a Therapeutic Category & Key Word Index.

    Includes:

    • 1054 drug monographs
    • Up to 42 Fields of Information per Monograph
    • More than 140 Extemporaneous Preparation Recipes
    • More than 120 Pages of Appendix Information
    • 27 New Drug Monographs
    • Updates to Hundreds of Existing Monographs, Including Updates Based on New Guideline Recommendations
    • Updated Appendix Topics:
      • Newborn Resuscitation Algorithm
      • Pediatric ALS (PALS) Algorithms
      • Adult ACLS Algorithms

    Oral Medications That Should Not Be Crushed or Altered

  • 465.00 lei

    Compiled by the Inspection, Enforcement and Standards Division, Medicines and Healthcare products Regulatory Agency (MHRA), London, UK

    This is the tenth edition of Rules and Guidance for Pharmaceutical Manufacturers and Distributors, compiled by MHRA. Commonly known as the Orange Guide, it remains an essential reference for all manufacturers and distributors of medicines in Europe. It provides a single authoritative source of European and UK guidance, information and legislation relating to the manufacture and distribution of human medicines.

    The new 2017 edition has been updated to incorporate changes and additions made to the detailed European Community guidelines on Good Manufacturing Practice (GMP) and the revised EU Guidelines on Good Distribution Practice (GDP), including Annexes 15 and 16.


    Comprehensive new content includes:
    • qualification of suppliers and customers
    • parallel importation and parallel distribution
    • temperature control and monitoring
    • UK legislation
    • unlicensed medicines

    There are new MHRA sections on:
    • GMP for excipients
    • guidance on revised Annex 16 of GMP
    • data Integrity definitions and guidance for industry

    Plus new Commission guidance on:
    • principles and guidelines of GMP for active substances
    • principles of GDP of active substances
    • setting health based exposure limits
    • formalised risk assessment for ascertaining the appropriate GMP for excipients.

    The work includes EU regulation on safety features for medicines, along with two Commission Q&As on the importation of active substances and safety features for medicinal products.

    A new appendix on sources of useful information has also been added.

    The Orange Guide is essential reading for anyone subject to MHRA inspection, providing you with all the answers you need to stay informed.

    It is compiled by the Inspection, Enforcement and Standards Division, MHRA, London, UK [www.gov.uk/mhra]

  • Drugs: From Discovery to Approval 3rd Edition
    by Rick Ng
    La comanda in aproximativ 4 saptamani
    467.00 lei

    The third edition of this best-selling book continues to offer a user-friendly, step-by-step introduction to all the key processes involved in bringing a drug to the market, including the performance of pre-clinical studies, the conduct of human clinical trials, regulatory controls, and even the manufacturing processes for pharmaceutical products. Concise and easy to read, Drugs: From Discovery to Approval, Third Edition quickly introduces basic concepts, then moves on to discuss target selection and the drug discovery process for both small and large molecular drugs. The third edition incorporates the latest developments and updates in the pharmaceutical community, provides more comprehensive coverage of topics, and includes more materials and case studies suited to college and university use. Biotechnology is a dynamic field with changes across R&D, clinical trials, manufacturing and regulatory processes, and the third edition of the text provides timely updates for those in this rapidly growing field.

  • 475.00 lei

    Features

      • Offers a comprehensive introduction to the fundamental concepts and underlying scientific principles of drug delivery and targeting

     

      • Presents an in-depth analysis of the opportunities and obstacles afforded by the application of nanotechnologies for drug delivery and targeting

     

      • Includes a revised and expanded section on the major epithelial routes of drug delivery currently under investigation

     

      • Describes the most recent, emerging, and innovative technologies of drug delivery

     

      • Provides real-life examples of the clinical translation of drug delivery technologies through the use of case studies

     

    • Discusses the pertinent regulatory hurdles and safety issues of drug delivery and targeting systems—crucial considerations in order to achieve licensing approval for these new technologies

    Summary

    This book provides a comprehensive introduction to advanced drug delivery and targeting, covering their principles, current applications, and potential future developments. This edition has been updated to reflect significant trends and cutting-edge advances that have occurred since the first edition was published. All the original chapters have been retained, but the material therein has been updated. Eight new chapters have been added that deal with entirely new technologies and approaches.

  • 550.00 lei

    The landmark text on how to achieve optimal patient outcomes through evidence-based medication therapy Pharmacotherapy: A Pathophysiologic Approach is written to help readers advance the quality of patient care through evidence-based medication therapy derived from sound pharmacotherapeutic principles. The scope of this trusted classic goes beyond drug indications and dosages to include the initial selection, proper administration, and monitoring of drugs. Readers will find everything they need to provide safe, effective drug therapy across the full range of therapeutic categories. This edition is enriched by more than 300 expert contributors, and every chapter has been revised and updated to reflect the latest in evidence-based information and recommendations. Important features such as Key Concepts at the beginning of each chapter, Clinical Presentation tables that summarize disease signs and symptoms, and Clinical Controversies boxes that examine the complicated issues faced by students and clinicians in providing drug therapy make this text an essential learning tool for students, patient-focused pharmacists, and other health care providers. Features: A section on personalized pharmacotherapy appears in most sections; All diagnostic flow diagrams, treatment algorithms, dosing guideline recommendations, and monitoring approaches are in full color to clearly distinguish treatment pathways; New drug monitoring tables have been added; Most of the disease-oriented chapters have incorporated evidence-based treatment guidelines that when available, include ratings of the level of evidence to support the key therapeutic approaches; Twenty-four online-only chapters are available at website.

  • 610.00 lei

    This volume will provide the reader with a good understanding of general pharmacological principles, together with knowledge of drugs likely to be encountered in both basic anaesthetic practice and current treatment of patients presenting for anaesthesia.

  • 613.00 lei

    Whilst following in the footsteps of previous volumes by presenting comprehensive reviews of drug substances and additional materials, this title also heralds a significant expansion of the scope of the series. Traditional contributions will now also be a

  • 670.00 lei

    THE LANDMARK TEXT ON HOW TO ACHIEVE OPTIMAL PATIENT OUTCOMES THROUGH EVIDENCE-BASED MEDICATION THERAPY Pharmacotherapy: A Pathophysiologic Approach is written to help you advance the quality of patient care through evidence-based medication therapy derived from sound pharmacotherapeutic principles. The scope of this trusted classic goes beyond drug indications and dosages to include the initial selection, proper administration, and monitoring of drugs. You will find everything you need to provide safe, effective drug therapy across the full range of therapeutic categories. This edition is enriched by more than 300 expert contributors, and every chapter has been revised and updated to reflect the latest evidence-based information and recommendations. Important features such as Key Concepts at the beginning of each chapter, Clinical Presentation tables that summarize disease signs and symptoms, and Clinical Controversies boxes that examine the complicated issues faced by students and clinicians in providing drug therapy make this text an essential learning tool for students, patient-focused pharmacists, and other health care providers. NEW TO THIS EDITION: A section on personalized pharmacotherapy appears in most sections All diagnostic flow diagrams, treatment algorithms, dosing guideline recommendations, and monitoring approaches have been updated in full color to clearly distinguish treatment pathways New drug monitoring tables have been added Most of the disease-oriented chapters have incorporated evidence-based treatment guidelines that often include ratings of the level of evidence to support the key therapeutic approaches Twenty-five online-only chapters are available at www.pharmacotherapyonline.com

  • 697.00 lei

    Description

    With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics.
    • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students
    • Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs
    • Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties
    • Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development
    • Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, all figures and tables from the book, and Power Point slides

  • Pediatric Formulations
    La comanda in aproximativ 4 saptamani
    702.00 lei

    Until the 1990s, it was generally accepted that medicines were first developed for adults and their use in children was investigated later, if at all. One of the main tasks of hospital pharmacies was the manufacturing of child-appropriate formulations in a more or less makeshift way. The first change came in 1997 with U.S. legislation that rewarded manufacturers to do voluntary pediatric research. Ten years later, the European Union passed legislation that required manufacturers to discuss all pediatric aspects, including formulations, with the regulatory authorities as a condition of starting the registration procedure. In consequence, manufacturers must now cover all age groups, including the youngest ones. So far, pediatric formulations were more a focus for academic researchers. Through the changed regulatory environment, there is now a sudden high commercial demand for age-appropriate formulations. This book begins by highlighting the anatomical, physiological and developmental differences between adults and children of different ages. It goes on to review the existing technologies and attempts to draw a roadmap to better, innovative formulations, in particular for oral administration.

  • 750.00 lei

    Features

    ·         Updates the current status of gelatin and gelatin alternatives in capsule shell production

    ·         Addresses capsules as a carrier platform both for oral modified release and technologies for solving difficult drug solubility problems

    ·         Discusses modeling in support of Quality-by-Design (QbD) and capsule formulation development and manufacture

    ·         Updates the role of capsules in clinical trials based on new technologies such as miniaturization for direct "Powder in a Capsule" filling and capsule engineering

    ·         Provides practical formulation, manufacturing, and regulatory considerations in development and scale-up

    ·         Updates the latest technologies in capsule shell filling and reviews historic developments in capsule filling

    ·         Presents many topics authored by experts in the field

    Summary

    Pharmaceutical Dosage Forms: Capsules covers the development, composition, and manufacture of capsules. Despite the important role that capsules play in drug delivery and product development, few comprehensive texts on the science and technology of capsules have been available for the research and academic environments. This text addresses this gap, discussing how capsules provide unique capabilities and options for dosage form design and formulation.

    Table of Contents

    1. Advances in Capsule Formulation Development and Technology

    [Larry L. Augsburger and Stephen W. Hoag]

    2. An Introduction to Two-Piece Hard Capsules and Their Marketing Benefits

    [Dennis Murachanian]

    3. Hard Shell Capsules in Clinical Trials

    [Moji Christianah Adeyeye and Amusa Adebayo]

    4. Capsule Shell Manufacture

    [Brian E. Jones, Fridrun Podczeck, and Paul Lukas]

    5. Non-Gelatin-Based Capsules

    [Sven Stegemann]

    6. Hard Shell Capsule Filling Machines

    [Donald K. Lightfoot]

    7. Instrumented Automatic Capsule Filling Machines and Filling Machine Simulation

    [Larry L. Augsburger and Vikas Moolchandani]

    8. Dry-Fill Formulation and Filling Technology

    [Pavan Heda, Vikas Agarwal, and Shailesh K. Singh]

    9. Plug Formation

    [Fridrun Podczeck]

    10. Modeling Powder Filling during Encapsulation

    [Ammar Khawam]

    11. Scale-Up and Transfer of Hard Shell Formulations across Machine Types

    [Larry L. Augsburger and Michael Levin]

    12. Modified-Release Delivery Systems: Extended-Release Capsule Platform

    [Reza Fassihi]

    13. Analytical Testing and Evaluation of Capsules

    [Stuart L. Cantor and Asish K. Dutta]

    14. Rheological Aspects of Capsule Shell Excipients and the Manufacture of Encapsulated Formulations

    [Lawrence H. Block]

    15. Quality-by-Design (QbD) for Capsule Formulation and Process Development: Regulatory Science Relevance, Scientific Case Studies, and Future Challenges

    [Huiquan Wu, Lin Xie, Stephen W. Hoag, Larry L. Augsburger, and Mansoor Khan]

  • 767.00 lei

    Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation design, including the interaction between the active pharmaceutical ingredient(s) (APIs), excipients and devices. This book seeks to cover some of the most pertinent issues and challenges of such formulation design associated with industrial production and desirable clinical outcome. The chapter topics have been selected with a view to integrating the factors that require consideration in the selection and design of device and formulation components which impact upon patient usability and clinical effectiveness. The challenges involved with the delivery of macromolecules by inhalation to both adult and pediatric patients are also covered. Written by leading international experts from both academia and industry, the book will help readers (formulation design scientists, researchers and post-graduate and specialized undergraduate students) develop a deep understanding of key aspects of inhalation formulations as well as detail ongoing challenges and advances associated with their development.

  • 789.00 lei

    As the generic pharmaceutical industry continues to grow and thrive, so does the need to conduct adequate, efficient bioequivalence studies. In recent years, there have been significant changes to the statistical models for evaluating bioequivalence. In addition, advances in the analytical technology used to detect drug and metabolite levels have made bioequivalence testing more complex. The second edition of Handbook of Bioequivalence Testing has been completely updated to include the most current information available, including new findings in drug delivery and dosage form design and revised worldwide regulatory requirements. New topics include: A historical perspective on generic pharmaceuticals New guidelines governing submissions related to bioequivalency studies, along with therapeutic code classifications Models of noninferiority Biosimilarity of large molecule drugs Bioequivalence of complementary and alternate medicines Bioequivalence of biosimilar therapeutic proteins and monoclonal antibodies New FDA guidelines for bioanalytical method validation Outsourcing and monitoring of bioequivalence studies The cost of generic drugs is rising much faster than in the past, partly because of the increased costs required for approval―including those for bioequivalence testing. There is a dire need to re-examine the science behind this type of testing to reduce the burden of development costs―allowing companies to develop generic drugs faster and at a lower expense. The final chapter explores the future of bioequivalence testing and proposes radical changes in the process of biowaivers. It suggests how the cost of demonstrating bioequivalence can be reduced through intensive analytical investigation and proposes that regulatory agencies reduce the need for bioequivalence studies in humans. Backed by science and updated with the latest research, this book is destined to spark continued debate on the efficacy of the current bioequivalence testing paradigm.

  • 837.00 lei

    Description
    Ibuprofen has become one of the foremost pain-relieving medications world-wide with its proven safety and efficacy in a wide variety of painful and inflammatory conditions. It has also been widely investigated for application in a variety of painful and non-pain inflammatory states including cancer and neurodegenerative conditions, reflecting the unique and novel properties of the drug that would never have been foreseen from knowledge of the properties when it was initially discovered.
    • Edited by leading world expert with over 40 years record in research, teaching and as a scientific advisor in the field of anti-inflammatory/analgesic agents. Professor Kim Rainsford is also the founding Editor-in-Chief of the journal, Inflammopharmacology, as well as being an Associate Editor of The Journal of Pharmacy & Pharmacology.
    • Provides a thorough coverage of the medicinal chemistry and pharmaceutics of ibuprofen, and its pharmacokinetics in both humans and animals.
    • Includes molecular, pharmacological and toxicological studies, and discusses the safety and efficacy of non-prescription ibuprofen, including its side effects. Ibuprofen: Discovery, Development & Therapeutics provides a definitive reference on all the main aspects of the chemical and pharmaceutical properties, mechanisms of action and therapeutic uses of ibuprofen including its role in the prevention and treatment of rheumatic conditions, cancer and neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases.
    The book has its origins in a volume first published in 1999, since when there have been considerable advances in research and clinical studies on ibuprofen in the treatment of many inflammatory and even non-inflammatory states. This book will prove invaluable to scientists, clinicians, pharmacists and all those who need to know about the actions and uses of anti-inflammatory and analgesic drugs.

  • 892.00 lei

    Covering fundamentals and new developments in phytotherapy, this book combines pharmaceutical sciences and chemistry with clinical issues.
    • Helps readers better understand phytotherapy and learn the fundamentals of and how to analyze phytotherapeutic agents
    • Discusses phytotherapy in modern medicine, chemoprevention of disease, and alternatives to western medicines for specific diseases
    • Chapters summarizes the uses and applications of phytomedicines, by type like Chinese, Greco-Arab, Indian, European, and Ayurvedic
    • Includes international regulatory perspectives and discusses emerging regulations for various established and emerging markets

  • 1040.00 lei

    Functional foods and nutraceuticals have received considerable interest in the past decade largely due to increasing consumer awareness of the health benefits associated with food. Diet in human health is no longer a matter of simple nutrition: consumers are more proactive and increasingly interested in the health benefits of functional foods and their role in the prevention of illness and chronic conditions. This, combined with an aging population that focuses not only on longevity but also quality of life, has created a market for functional foods and nutraceuticals. A fully updated and revised second edition, Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods reflects the recent upsurge in "omics" technologies and features 48 chapters that cover topics including genomics, proteomics, metabolomics, epigenetics, peptidomics, nutrigenomics and human health, transcriptomics, nutriethics and nanotechnology. This cutting-edge volume, written by a panel of experts from around the globe reviews the latest developments in the field with an emphasis on the application of these novel technologies to functional foods and nutraceuticals.

  • Stockley's Drug Interactions
    La comanda in aproximativ 4 saptamani
    1230.00 lei

    Stockley's Drug Interactions : A source book of interactions, their mechanisms, clinical importance and management This eleventh edition of Stockley’s Drug Interactions is the most comprehensive and authoritative international source of drug interaction information. Stockley’s Drug Interactions, edited by Claire L Preston, remains the world’s most comprehensive and authoritative international reference book on drug interactions. Based upon thousands of published papers and reports this eleventh edition: · Covers interactions between therapeutic drugs, proprietary medicines, herbal medicines, foods, drinks, and drugs of abuse · Contains in-depth yet concise monographs in an easy-to-read format · Provides comprehensive details of the clinical evidence for the interactions under discussion, an assessment of their clinical importance, and clear guidance on managing the interaction in practice · Has a brief summary of the interaction in each monograph – perfect for the busy healthcare professional · Is fully referenced throughout · Contains almost 4500 monographs · Is global in coverage – inclusion of drugs used worldwide New in the 11th edition: · Over 350 new monographs added · Many existing monographs have been reviewed, revalidated, and updated · A comprehensive update and restructure of the chapter on Antidiabetic drugs, in-line with published literature · Addition of new advice regarding the concurrent use of aliskiren, ACE inhibitors, and angiotensin-II receptor antagonists · An updated list of drugs that have a risk of prolonging the QT interval · The addition of new drugs, including apixaban, apremilast, dolutegravir, lomitapide, mirabegron, the NS5A inhibitors (daclatasvir, ledipasvir, ombitasvir), the NS5B inhibitors (dasabuvir, sofosbuvir), the sodium-glucose co-transporter-2 inhibitors (canagliflozin, dapagliflozin, empagliflozin), and telavancin

  • Drug Facts and Comparisons 2016
    La comanda in aproximativ 4 saptamani
    1290.00 lei

    Drug Facts and Comparisons provides up-to-date information on over 22,000 Rx and 6,000 OTC products grouped by therapeutic category for ease of comparison. Drug Facts and Comparisons helps answer questions about actions, indications and contraindications, warnings and precautions, drug interactions, adverse reactions, administration and dosage, and pregnancy and lactation. Comparisons include drug to drug, dosage forms, and name brands to name brands and generics. Biologicals and antiparasitic drugs, IV solutions, and therapeutic ophthalmic preparations are also included. This hardbound edition includes the Drug Identifier 2016 CD-ROM, the premier tool for drug identification. Search more than 10,000 color images in seconds by drug name, imprint, NDC, color, shape, manufacturer, coating, scoring, clarity, and flavor. Features: ·Over 22,000 Rx and 6,000 OTC products, including generic and trade names ·More than 3,000 easy-to-read charts and comparative tables ·Drug Identifier 2016 CD-ROM offers more than 10,000 color images searchable by drug name, imprint, NDC, color, shape, manufacturer, coating, scoring, clarity, and flavor. ·Extensive manufacturer/distributor list

  • 1,80000lei 1440.00 lei

    This special issue of the Handbook of Experimental Pharmacology on Heart Failure covers the entire spectrum of the field, from the current understanding and definitions of heart failure, to epidemiology and the importance of co-morbidities, clinical trial design and biomarkers, as well as imaging technologies. The main focus of this book is to review current and emerging heart failure therapies and potential targets for treatment.

  • 2,59300lei 2200.00 lei

     Features

    • The definitive major reference work in the field, covering key information that the infectious diseases specialist will need to know about antimicrobial drugs
    • Comprehensive coverage of the drug available, including those new to the market and, importantly, those currently under trial
    • Highly standardized content, structured for ease of reference
    • Globally applicable, compiled by an international team of expert editors and contributors
    • Added to this edition - new antivirals, particularly the highly effective compounds now available to treat HIV and viral hepatitis; new antibiotics - beta-lactamase inhibitors and cephalosporins, quinolones and fluoroquinolones, anti-tuberculosis agents; plus new antifungals and antiparasitics.

    Summary

    Kucers’ The Use of Antibiotics is the definitive, internationally-authored reference, providing everything that the infectious diseases specialist and prescriber needs to know about antimicrobials in this vast and rapidly developing field. The much-expanded Seventh Edition comprises 4800 pages in 3 volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into four sections - antibiotics, anti-fungal drugs, anti-parasitic drugs, and anti-viral drugs - and is highly structured for ease of reference.

    Each chapter is organized in a consistent format, covering susceptibility, formulations and dosing (adult and pediatric), pharmacokinetics and pharmacodynamics, toxicity, and drug distribution, with detailed discussion regarding clinical uses - a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with expert contributors representing Europe, Africa, Asia, Australia, South America, the US, and Canada, the Seventh Edition adopts a truly global approach. It remains invaluable for anyone using antimicrobial agents in their clinical practice and provides, in a systematic and concise manner, all the information required when prescribing an antimicrobial to treat infection.

    Table of Contents

    Foreword, Obituary: Dr. Alvis Kucers, Hail the Greats, Preface, Abbrieviations. 

    SECTION I Introduction.

    SECTION II Antibiotics: Part 1 Penicillins and related drugs, Part 2 Cephalosporins and related drugs, Part 3 Carbapenems, Part 4 Glycopeptides and lipopeptides, Part 5 Aminoglycosides, Part 6 Macrolides and Ketolides, Part 7 Tetracyclines and related drugs, Part 8 Other antibiotics, Part 9 Anti-folate agents and other synthetic antibacterials, Part 10 Nitroimidazoles, Part 11 Quinolones and Fluoroquinolones. Part 12 Anti-tuberculosis drugs.

    SECTION III Antifungal drugs: Part 1 Polyenes, Part 2 Echinocandins, Part 3 Allylamines and benzylamine derivatives, Part 4 Systemic azoles, Part 5 Topical azoles, Part 6 Topical agents—thiocarbomates, hydroxypyridones, and morpholine, Part 7 Other antifungal agents.

    SECTION IV Antiparasitic drugs: Part 1 Anti-malarial drugs, Part 2 Agents active against intestinal and extra-intestinal protozoa, Part 3 Agents active against American trypanosomiasis, Part 4 Agents active against African trypanosomiasis, Part 5 Agents active against leishmania and other pathogens, Part 6 Agents active against helminths, Part 7 Agents active against ectoparasites.

    SECTION V Antiviral drugs: Part 1 Agents active against herpesviruses, Part 2 Agents active against the human immunodeficiency virus, Part 3 Agents active against hepatitis viruses, Part 4 Agents active against influenza viruses, Part 5 Investigational antiviral drugs.

  • 2300.00 lei

    The Handbook of Pharmaceutical Excipients collects together essential data on the physical properties of excipients as well as providing information on their safe use and applications. All of the 400+ monographs are also thoroughly cross-referenced and indexed to allow their identification by chemical, non-proprietary or trade names. It is internationally recognised as the authoritative source of information on pharmaceutical excipients and a comprehensive guide to uses, properties and safety.


    Changes to this new edition:

    • Contains revised and updated monographs
    • 20 + new monographs including amino acids Arginine, Proline and Asparagine
    • Includes newly added Raman spectra for many excipients
    • New chapter content including information on excipients in oral solid dose formulations, and pediatric formulations

  • 2301.00 lei

    A comprehensive review of the current status of antidepressants - how we arrived at this point in their evolution and where we are going in both the near and the long term. It employs both a scientific and historical approach to accomplish these goals. This volume is intended for practitioners who use antidepressants on a daily basis in their practice as well as for the student and researcher. Each will find that it provides a comprehensive and logical approach to this important group of medications. This book is being published as we mark the end of the first 50 years of the modern antidepressant era.

  • 2330.00 lei

    Comprises almost 1,500 individual drug articles providing the coverage of adverse reactions and interactions. This title features encyclopedic format with drug monographs organised alphabetically. It provides systematic organization of information for easier reading including case histories to provide perspective on each listing.

  • European Pharmacopoeia Supplements 9.3-9.5
    by EDQM
    La comanda in aproximativ 4 saptamani
    2900.00 lei

    The 9th edition of the European Pharmacopoeia (EP), main volume and supplements, is legally binding and details the qualitative and quantitative composition of medicines, the tests to be carried out on medicines, the raw materials used in the production of medicines and on the intermediates of synthesis.

    The EP is a single reference work for the quality control of medicines in Europe. All producers of medicines or substances for pharmaceutical use must apply the quality standards of the European Pharmacopoeia for the marketing and use of these products in Europe.

     

    These supplements contain all the regulatory information that will come into force in the course of 2018. They complement the 9th Edition launched last year and bring the total number of monographs to 2351 (including dosage forms), along with 361 general texts (including general monographs and methods of analysis) and around 2670 descriptions of reagents.

     

    KEY FEATURES

     

    · Applicable in 38 European countries and used in over 100 worldwide.

    · Delivers crucial information earlier than any other Pharmacopoeia.

    · Over 50% new or revised texts compared to the previous edition.

    · All versions (online, print and the NEW downloads) allow free access to the Knowledge Database and the online archives.

     

    PUBLICATIONS & IMPLEMENTATION DATES

    VOLUME PUBLICATION DATE IMPLEMENTATION DATE

     

    9.3 July 2017 01 January 2018

    9.4 October 2017 01 April 2018

    9.5 January 2018 01 July 2018

     

  • Martindale: The complete drug reference
    La comanda in aproximativ 4 saptamani
    3175.00 lei

    Martindale: The Complete Drug Reference provides unbiased and evaluated information on drugs and medicines in use around the world. It is prepared by an experienced team of pharmacists and life scientists who use their professional expertise to select the most clinically relevant and appropriate information from reliable published sources, to provide an unbiased and evaluated digest of the literature.

    Unique benefits:

    ·         Breadth: No other source has the breadth of coverage or level of detail making it the ideal first-line reference work as well as a trusted source of information for more detailed drug enquiries

    ·         Global coverage: Martindale is the leading resource in terms of international coverage, with 43 countries covered – alternative publications have a narrow regional focus

    ·         Objectivity: Respected for its accuracy of content and independence from pharmaceutical industry. Based on published information and extensively referenced

    ·         International adoption: Recognised and adopted worldwide


    In two hardback volumes, Martindale contains:

    ·         Over 6,300 drug monographs (and over 7,500 online, accessible via a subscription to MedicinesComplete)

    ·         Over 185,000 preparations (and over 270,000 online, via MedicinesComplete)

    ·         Over 54,000 reference citations

    ·         Over 20,000 (and 28,000 online, via MedicinesComplete) manufacturers and distributors

    ·         Proprietary preparations from 43 countries and regions

    ·         Nearly 700 treatment reviews, with references from the published literature

    ·         Information to help you identify medicines, the local equivalent and the manufacturer

    ·         Herbals, diagnostic agents, radiopharmaceuticals, pharmaceutical excipients, toxins, and poisons as well as drugs and medicines

    Improvements for the 39th edition include:

    ·         Over 130 new monographs, including:

    o    Lumacaftor: a cystic fibrosis transmembrane conductance regulator (CFTR) protein corrector

    o    Pitolisant: a central stimulant used in the treatment of narcolepsy

    o    Rolapitant: a neurokinin-1 receptor antagonist that is used for the prevention of nausea and vomiting associated with cancer chemotherapy

    o    Umeclidinium Bromide: a quaternary ammonium antimuscarinic used as a bronchodilator in the treatment of reversible airways obstruction

    ·         New Hepatitis C treatment table and drugs including ledipasvir, ombitasvir, paritaprevir, and dasabuvir

    ·         Coverage of proprietary preparations in 43 countries including Australia, China, UK, and USA, revised and updated

  • 3225.00 lei

    The 9th Edition of the European Pharmacopoeia (EP), main volume and supplements, is legally binding and details the qualitative and quantitative composition of medicines, the tests to be carried out on medicines, the raw materials used in the production of medicines and on the intermediates of synthesis. The EP is a single reference work for the quality control of medicines in Europe. All producers of medicines or substances for pharmaceutical use must apply the quality standards of the European Pharmacopoeia for the marketing and use of these products in Europe. Earliest access to all European quality standards that come into effect on 1 January 2017. The European Pharmacopoeia is Europe’s legal and scientific benchmark for pharmacopoeial standards which contribute to delivering high quality medicines in Europe and beyond. It is applicable in 37 European countries and used in over 100 countries worldwide. It delivers crucial information earlier than any other pharmacopoeia – the 9th Edition will be released in mid-2016. With 121 new and 1,403 revised texts, over 50% of the 9th Edition’s content is new compared to the 8th Edition. The 9th Edition will consist of 3 initial volumes (9.0) and 8 non-cumulative supplements (9.1 to 9.8). Volumes 1, 2 and 3 combined contain 2329 monographs (including dosage forms), 358 general texts (including general monographs and methods of analysis) and around 2600 descriptions of reagents. New feature: it includes a direct link to the KNOWLEDGE database from each monograph. Mission The purpose of the European Pharmacopoeia is to promote public health by the provision of recognised common standards for the quality of medicines and their components. Such standards are to be appropriate as a basis for the safe use of medicines by patients. In addition, their existence facilitates the free movement of medicinal products in Europe and beyond. European Pharmacopoeia monographs and other texts are designed to be appropriate to the needs of: · regulatory authorities; · those engaged in the quality control of medicinal products and their constituents; · manufacturers of medicinal products and their individual components. The European Pharmacopoeia is widely used internationally. As globalisation and expansion in international trade present a growing need to develop global quality standards for medicines, the Commission works closely with all users of the Pharmacopoeia worldwide.

  • 5750.00 lei

    The USP 39-NF 34 standards will be deemed official by 1 May 2016. The USP is enforceable by the U.S. Food and Drug Administration for medicines manufactured and marketed in the United States. The USP-NF is a combination of two official compendia, the United States Pharmacopeia (USP) and the National Formulary (NF). The USP-NF contains standards for medicines, dosage forms, drug substances, excipients, biologics, compounded preparations, medical devices, dietary supplements, and other therapeutics. Includes a four-volume print main edition and two separate print supplements. Printed on thick, durable paper stock, for laboratory and manufacturing use. Each volume contains a complete table of contents and index. Shipped with a slipcase for easy access and storage. Highlights & Features More than 4,900 monographs with specifications for identity, strength, quality, purity, packaging, and labeling for substances and dosage forms. More than 300 general chapters providing clear, step-by-step guidance for assays, tests, and procedures Focus-specific charts and a combined index help you find the information you need Helpful sections on reagents, indicators, and solutions, plus reference tables Includes new General Chapter <800> Hazardous Drugs—Handling in Healthcare Settings Key Features · 24 new and revised general chapters · 87 new and revised monographs · Focus-specific charts and a combined index help you find the information you need · Helpful sections on reagents, indicators, and solutions, plus reference tables The USP-NF offers convenient, comprehensive information for all phases of producing quality prescription, non-prescription, and compounded medicines; excipients; biologics; medical devices; and dietary supplements. It is essential for quality control, quality assurance, regulatory/compendial affairs, research and development, method development/analytical services, and corporate management. Benefits & Applications The USP–NF offers convenient, comprehensive information for all phases of producing quality prescription, nonprescription, and compounded medicines; excipients; biologics; medical devices; and dietary supplements. It is essential for quality control, quality assurance, regulatory/compendial affairs, research and development, method development/analytical services, and corporate management. USP–NF monographs and methods can help to Ensure compliance with required U.S. quality standards Work to world-recognized standards of precision and accuracy Validate test results against proven benchmarks Establish and validate in-house standard operating procedures, and specifications Expedite new product development and approvals A Valuable Reference for: Scientists, professionals, and students working in or with: Pharmaceuticals—prescription and nonprescription drugs Biological and biotechnology products Blood and blood products Compounded preparations Cosmetics Dietary supplements Excipients/other drug ingredients Medical devices Medical gases Medical libraries Pharmacies Schools of medicine and pharmacy Veterinary drugs

  • The British Pharmacopoeia 2017
    La comanda in aproximativ 4 saptamani
    6060.00 lei

    The British Pharmacopoeia (BP) 2017 supersedes the BP 2016 and becomes legally effective on 1 January 2017. This edition incorporates new BP and European Pharmacopoeia monographs and a significant number of revised monographs. Also included is new information for unlicensed medicines and DNA barcoding.

    To ensure you get the best value access to the information you need, there are a range of flexible licences, formats and package options available to choose from.

    The British Pharmacopoeia 2017 package

    • A six-volume printed edition, including the BP (Veterinary) 2017

    • A single-user online licence*

    • A single-user download for offline use*

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