Brody’s Human Pharmacology: Mechanism-Based Therapeutics

Brody¿s Human Pharmacology is a well-established and much-loved textbook that guides students of medicine, pharmacology and other health professions through pharmacology from both basic and clinical perspectives.

What can be a very difficult and complex topic is divided into easily digestible chapters, each of which is clearly structured from a therapeutic overview to mechanisms of action, relationships to clinical responses, pharmacokinetics, pharmacovigilance, new developments, and clinical relevance for all health professionals.

Contains all the essential aspects of pharmacology ¿ suitable for exam preparation

Full color illustrations explain important processes and color-coded boxes enhance understanding

Therapeutic overviews, clinical problems and trade names ¿ everything you need to know

Self-assessment questions and further reading to reinforce learning

Current developments for each class of drugs and how information relates to students in the healthcare professions bring learning to life

Updated content throughout

Pharmacodynamics chapter revised to include discussions of positive and negative allosteric modulators, as well as biased agonism

Pharmacogenetics chapter considers genetic variations and their relationship to drug responses

Section on cancer drugs revised to reflect major advances

New chapter on immunological and cell-based therapies

Table of Contents:

Section 1 Mechanisms of Drug Action and Therapeutic Principles
1. Introduction
Susan L. Ingram and Lynn Wecker
2. Pharmacodynamics: Receptors and Concentration-Response Relationships
JoAnn Trejo, Laura M. Bohn and James Carlton Garrison II
3. Pharmacokinetics
Namandje Bumpus and Paul Frederick Hollenberg
4. Pharmacogenomics
Larisa Cavallari, Scott A. Mosley and Emily J. Cicali
5. Drug Discovery, Development and Regulation
Felix Kim, Lance McMahon, James Barrett, Samuel Obeng and Christopher R. McCurdy
Section 2 Chemical Mediators and Drugs Affecting Autonomic and Neuromuscular Synapses
6. Introduction to the Autonomic Nervous System
Marsha L. Pierce and Lynn Wecker
Cholinergic Drugs
7. Muscarinic Agonists, Cholinesterase Inhibitors and Their Clinical Uses
Naoto Hoshi and Frederick J. Ehlert
8. Muscarinic  Antagonists and Their Clinical Uses
Naoto Hoshi and Frederick J. Ehlert
9. Nicotinic Agonists and Their Clinical Uses
Marsha L. Pierce and Lynn Wecker
10. Neuromuscular Blocking Drugs and Nicotinic Antagonists
Marsha L. Pierce and Lynn Wecker
Adrenergic Drugs
11. Adrenergic Agonists and Their Clinical Uses
Javier Cuevas
12. Adrenergic Antagonists and Their Clinical Uses
Javier Cuevas
Section 3 Drug Treatment for Disorders Affecting the Central Nervous System
13. The Central Nervous System
Susan L. Ingram and Lynn Wecker
14. Drug Therapy for Alzheimer's Disease and Other Cognitive Disorders/Dementias
Michael S. Jaffee, Steven Trent DeKosky, Meredith Wicklund and Benjamin Albert Chapin
15. Pharmacotherapy of Basal Ganglia Disorders: Parkinson Disease and Huntington Disease
Samba Reddy and Juan R. Sanchez-Ramos
16. Drug Therapy for Psychoses and Bipolar Disorder
Glenn Catalano, Deborah L. Sanchez, Lynn Wecker and Cory M. Klippel
17. Drug Therapy for Depression and Anxiety
Glenn Catalano, Deborah L. Sanchez, Lynn Wecker and Greg Sullivan
18. Drug Therapy for the Management of Attention Deficit-Hyperactivity Disorder
Samba Reddy
19. Drug Therapy for Insomnia and the Hypersomnias
Miranda Lim and Lynn Wecker
20. Drug Therapy for Managing Obesity and Eating Disorders
Charles Rudick
21. Treatment of Seizure Disorders
Michael A. Rogawski
22. Drug Therapy for Spasticity Disorders
Samba Reddy
23. Ethanol, Other Alcohols and Drugs for Alcohol Use Disorder
Jesse D. Hinckley and christian J. Hopfer
24. Illicit Psychoactive Compounds and Substance Use Disorder
Jeffery Block and Rex M. Philpot
Section 4 Drug Therapy for Pain Management
25. Introduction
Susan L. Ingram
26. General Anesthetics
Jeffrey J. Pasternak and Tasha L. Welch
27. Local Anesthetics
Guy Weinberg and Joshua Edwards
28. Opioid Analgesics
Susan L. Ingram and Elena Bagley
29. Nonsteroidal Anti-inflammatory Agents and Acetaminophen
Jennelle Durnett Richardson and Jill Fehrenbacher
30. Cannabinoids as Analgesics
Jeffery Block, Rex M. Philpot and Lynn Wecker
31. Drug Therapy for Migraine Headache
Samba Reddy
Section 5 Treatment of Inflammatory, Allergic and Immunologic Disorders
32. Drug Therapy for Gout and Hyperuricemia
Angelo Gaffo and Keith Elmslie
33. Drug Therapy for Allergic Reactions
Annette Gilchrist and Angela Karash
34. Immunosuppressants for Autoimmune Disorders and Organ Transplantation
Kymberly Gowdy, Mythili Chunduru and Jennifer Anne Ferrante
35. Drug Therapy for Rheumatoid Arthritis
Michelle Jane Ormseth and Keith Elmslie
Section 6 Drug Treatment for Cardiovascular Diseases
36. Introduction to the Regulation of Cardiovascular Function
Beth A. Habecker, David A. Taylor, Abdel A. Abdel-Rahman and Steven E. Mansoor
37. Overview of Hypertension Management and Drugs That Decrease Sympathetic Tone
James A. McCormick, David A. Taylor and Abdel A. Abdel-Rahman
38. Diuretics and Drugs That Affect Volume and Electrolyte Content
James A. McCormick and Abdel A. Abdel-Rahman
39. Drugs Affecting the Renin-Angiotensin- Aldosterone System
Vardan T. Karamyan and Abdel A. Abdel-Rahman
40. Calcium Channel Blockers
Kelly Karpa and Ryan Wilson
41. Vasodilators for Hypertensive Crises, Pulmonary Hypertension and Erectile Dysfunction
David Anthony Tulis and David S. Middlemas
42. Drug Therapy for Hyperlipidemias and Atherosclerotic Cardiovascular Disease
Dan F. McCune, Michael T. Piascik and Robert Hadley
43. Drug Therapy for Myocardial Ischemia and Angina Pectoris
David A. Taylor and J. West Paul
44. Treatment of Heart Failure
Ashley Guillory, Michael T. Piascik and Robert Hadley
45. Antiarrhythmic Drugs
David A. Taylor and Stephanie W. Watts
46. Anticoagulant, Antiplatelet and Fibrinolytic Medications
Paul T. Kocis, Francis Herrmann, Kelly Karpa and Kent E. Chair
47. Drug Therapy for Hemophilia and the Deficiency Anemias
Pamela E. Potter and David A. Taylor
Section 7 Treatment of Endocrine Disorders
48. Introduction to Endocrine Pharmacology
James J. O'Donnell III
49. Treatment of Hypothalamic and Pituitary Disorders
Gerald B. Call and James J. O'Donnell III
50. The Pharmacology of Adrenocorticosteroid Disorders
James J. O'Donnell III and Gerald B. Call
51. Female Hormone Regulation
David S. Middlemas and Julia Ousterhout
52. Androgens, Antiandrogens, and Their Clinical Uses
David S. Middlemas
53. Drug Therapy for the Management of Diabetes
Phillip Kopf and Julio A. Copello
54. Drug Therapy for the Management of Thyroid Disorders
James J. O'Donnell III and Gerald B. Call
55. Calcium Regulating Hormones and Other Agents Affecting Bone
James J. O'Donnell III and Gerald B. Call
Section 8 Chemotherapy
Infectious Diseases
56. Principles of Antimicrobial Use
Rukiyah Van Dross-Anderson and Eman Soliman
57. Drugs Targeting Bacterial Cell Walls and Membranes
Rukiyah Van Dross-Anderson and Daniel Ladin
58. Drugs Targeting Bacterial Protein Synthesis
Rukiyah Van Dross-Anderson and Daniel Ladin
59. Drugs Targeting Bacterial DNA
Rukiyah Van Dross-Anderson and Eman Soliman
60. Antimycobacterial Agents
Rukiyah Van Dross-Anderson and Eman Soliman
61. Drug Targeting Resistant Organisms
Rukiyah Van Dross-Anderson and Daniel Ladin
Parasitic Diseases
62. Antifungal Agents
Mona McConnaughey
63. Antimalarial and Other Antiprotozoal Agents
Joseph Stone Doggett and Michael Conte
64. Antihelmintics and Ectoparasiticides
Mona McConnaughey
Viruses
65. Antiviral Agents
Susan L. Ingram
66. Antiretroviral Drugs for HIV
Amy Wecker
Cancer
67. Principles of Antineoplastic Drug Use
Stephanie Huang, John Stephen Lazo, Yingbo Huang and Robert Gruener
68. Cytotoxic Agents
Jian-Ting Zhang, Amit K. Tiwari and Mary-Ann Bjornsti
69. Targeted Anticancer Agents
Jian-Ting Zhang, Amit K. Tiwari and Jill Marie Siegfried
70. Immunological and cell-based therapies
Ahmad Tarhini, Turkan Ozturk Topcu and Iyad Kobeissi
Section 9 Special Considerations
71. Therapeutic Use of Hematopoietic Growth Factors
Pamela E. Potter
72. Gastrointestinal Disorders and Their Treatment
Phillip Kopf
73. Pharmacological Treatment of  Asthma and COPD
Annette Gilchrist and Angela Karash
74. The Role of Neutraceuticals and Natural Products
Robert C. Speth and Pamela E. Potter
75. Essentials of Toxicology
Monica Valentovic, Lauren Aleksunes and Gary Rankin
76. Therapeutic Considerations for Pregnant, Pediatric, Geriatric and Obese Individuals
Susan L. Ingram