Textbook of Receptor Pharmacology

Book Description:

For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. This third edition continues to combine current understanding of classical quantitative pharmacology and drug-receptor interactions with the basics of receptor structure and signal transduction mechanisms, providing an integrated analysis of the mechanisms of drug action at membrane receptors.

The hallmark of this popular text is the uniting of four major approaches to the study of receptors:

Molecular investigation of receptor structure

Quantitative functional studies of agonists and antagonists

Ligand binding

Signal transduction at the cell membrane

Maintaining the second edition’s focus on cell membrane receptors and the immediate signal transduction events at the membrane, this edition includes updated chapters on receptor structure and signal transduction by G-proteins and tyrosine kinases as well as enhancements to the quantitative treatment of drug-receptor interactions. Several chapters contain problems and worked-out solutions, giving students the ability to test their comprehension of the material. Hundreds of diagrams and figures further enhance the text.

A time-saving resource and comprehensive learning tool, Textbook of Receptor Pharmacology, Third Edition carries on the tradition of providing in-depth, up-to-date coverage of this critical area that is both fundamental to the science of pharmacology and on the cutting edge of new drug development.

Table of Contents

Drug-Receptor Interactions

Classical Approaches to the Study of Drug-Receptor Interactions, Donald H. Jenkinson

Molecular Structure of Receptors

Structure and Function 7-TM G-Protein Coupled Receptors, Alasdair J. Gibb

The Structure of Ligand-Gated Ion Channels, Jan Egebjerg

Molecular Structure of Receptor Tyrosine Kinases, IJsbrand Kramer and Michel Laguerre

Ligand-Binding Studies of Receptors

Direct Measurement of Drug Binding to Receptors, Dennis G. Haylett

Transduction of the Receptor Signal

Receptors Linked to Ion Channels: Mechanisms of Activation and Block, Alasdair J. Gibb

G-Proteins, David A. Brown

Signal Transduction through Protein Tyrosine Kinases, IJsbrand Kramer and Elisabeth Genot

Receptors as Pharmaceutical Targets

Receptors as Pharmaceutical Targets, James W. Black