Hematologic Malignancies

Explains the significance of the results obtained towards the prognosis and treatment response

Presents several case studies in hematologic malignancies with particular reference to cytogenetics

Describes a vision of future development towards enhancing diagnosis and application of targeted therapies

About this book

This book is a compendium of case studies in hematologic malignancies such as acute leukemias, myelodysplastic and myeloproliferative neoplasms, chronic leukemias and multiple myeloma covering cytogenetics (karyotyping Fluorescence in sitn hybridization (FISH)) and molecular studies in detail.  The first few chapters describe the methodology employed for karyotyping, FISH and Real Time PCR technology conducive to establishment of these labs if required. Each case study is described in detail by including the clinical history of the patient, findings of peripheral blood, bone marrow aspirate and bone biopsy morphological details. This is then followed by flowcytometric immunophenotyping, cytogenetic and molecular observations leading collectively to a final diagnosis. A discussion follows based on the relevance of this data in informing the prognosis, treatment response and survival in these patients.

Additionally, this data serves as a key determinant for clinical decision making involving evidence based rational management of patients including targeted therapy. For better understanding, each case study is accompanied by black and white or colour images as appropriate. This book is a source of learning and a valuable read for clinical hematologists, hematopathologists, medical oncologists, residents, interns, DM Hematology students and DNB Hematology students as well.

Table of contents (11 chapters)

Front Matter

Pages i-xxvi

Techniques in Cytogenetics

Manorama Bhargava

Pages 1-16

Techniques in Molecular Hematology

Manorama Bhargava

Pages 17-35

Case Studies in Myeloid Malignancies

Acute Myeloid Leukemia

Manorama Bhargava

Pages 39-99

Myelodysplastic Syndrome

Manorama Bhargava

Pages 101-118

Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN)

Manorama Bhargava

Pages 119-131

Myeloproliferative Neoplasms (MPNs)

Manorama Bhargava

Pages 133-138

Chronic Myeloid Leukemia

Manorama Bhargava

Pages 139-146

Next Generation Sequencing for Diagnostics of Myeloid Malignancies for Routine Clinical Use: Pitfalls and Advantages

Manorama Bhargava

Pages 147-147

Case Studies in Lymphoid Malignancies

Acute Lymphoblastic Leukemia

Manorama Bhargava

Pages 151-193

Chronic Lymphocytic Leukemia and Non-Hodgkin’s Lymphomas

Manorama Bhargava

Pages 195-224

Case Studies in Multiple Myeloma

Multiple Myeloma

Manorama Bhargava

Pages 227-246