The Washington Manual Hematology and Oncology Subspecialty Consult

 

Concise, portable, and user-friendly, The Washington Manual Hematology and Oncology Subspecialty Consult, 5th Edition, provides quick access to the essential information needed to evaluate a patient on a hematology-oncology subspecialty consult service. Edited by Drs. Brian A. Van Tine and Meagan A. Jacoby, this best-selling manual offers state-of-the-art content, including coverage of new therapies such as CAR T-cell therapy, new anti-cancer drugs, and new biomarkers and therapeutic targets. Ideal for fellows, residents, and medical students rotating on hematology and oncology subspecialty services, the manual is also useful as a first-line resource for advanced practice providers, general internal medicine physicians, Hem/ONC fellows, and other primary care providers.

 

Contents

PART I. HEMATOLOGY

1. Introduction and Approach to Hematology

Approach to the Hematology Patient

GENERAL PRINCIPLES

Definition

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

Diagnostic Procedures

2. White Blood Cell Disorders: Leukopenia and Leukocytosis

Leukopenia

GENERAL PRINCIPLES

Neutropenia

GENERAL PRINCIPLES

Definition

Epidemiology

Etiology

Pathophysiology

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Lymphocytopenia

GENERAL PRINCIPLES

Definition

Etiology

TREATMENT

Leukocytosis

GENERAL PRINCIPLES

Definition

Classification

Etiology

Pathophysiology

DIAGNOSIS

Neutrophilia

GENERAL PRINCIPLES

Definition

Pathophysiology

DIAGNOSIS

Differential Diagnosis

Diagnostic Testing

TREATMENT

Eosinophilia

GENERAL PRINCIPLES

DIAGNOSIS

TREATMENT

Basophilia

GENERAL PRINCIPLES

Definition

Etiology

DIAGNOSIS

Monocytosis

GENERAL PRINCIPLES

Definition

Etiology

DIAGNOSIS

Lymphocytosis

GENERAL PRINCIPLES

DIAGNOSIS

TREATMENT

3. Red Blood Cell Disorders

Anemia

GENERAL PRINCIPLES

Definition

Etiology

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

ANEMIAS ASSOCIATED WITH DECREASED PRODUCTION

Microcytic Anemias

Iron-Deficiency Anemia

GENERAL PRINCIPLES

Etiology

DIAGNOSIS

TREATMENT

Sideroblastic Anemias

Lead Poisoning

Anemia of Chronic Disease

Thalassemias

GENERAL PRINCIPLES

Epidemiology

Pathophysiology

TREATMENT

Normocytic Anemias

Anemia of Chronic Disease (Anemia of Chronic Inflammation)

Myelophthisic Anemias

Anemia of Chronic Renal Failure

Endocrine Disorders

Macrocytic Anemias

Vitamin B12 Deficiency

GENERAL PRINCIPLES

Etiology

Clinical Presentation

DIAGNOSIS

Diagnostic Testing

TREATMENT

MONITORING/FOLLOW-UP

Folate Deficiency

Drug-Induced Anemia

Nonmegaloblastic Anemia

ANEMIAS ASSOCIATED WITH INCREASED DESTRUCTION

Location of Hemolysis

Mechanism of Hemolysis

Hemolytic Anemias

GENERAL PRINCIPLES

DIAGNOSIS

Sickle Cell Anemia

Glucose-6-Phosphate Dehydrogenase Deficiency

Hereditary Spherocytosis (Membrane Defect)

Acquired Immune Hemolytic Anemia

WARM ANTIBODY

COLD ANTIBODY

Acquired Nonimmune Hemolytic Anemia

Polycythemia

4. Platelets: Thrombocytopenia and Thrombocytosis

Thrombocytopenia

GENERAL PRINCIPLES

Definition

Classification

DIAGNOSIS

Clinical Presentation

Differential Diagnosis

Immune-Mediated Thrombocytopenia

GENERAL PRINCIPLES

Definition

Classification

DIAGNOSIS

Clinical Presentation

DIAGNOSTIC TESTING

TREATMENT

First-Line Therapy

Second-Line Therapy

Refractory ITP

Emergency Therapy

Thrombotic Thrombocytopenic Purpura, Hemolytic-Uremic Syndrome, and Complement-Mediated (Atypical) Hemolytic-Uremic Syndrome

GENERAL PRINCIPLES

Definition

Epidemiology

Pathophysiology

DIAGNOSIS

Differential Diagnosis

Clinical Presentation

Diagnostic Criteria

TREATMENT

Disseminated Intravascular Coagulation

GENERAL PRINCIPLES

Definition

Epidemiology

Pathophysiology and Etiology

Risk Factors and Associated Conditions

DIAGNOSIS

Clinical Presentation

Diagnostic Criteria

TREATMENT

Heparin-Induced Thrombocytopenia

GENERAL PRINCIPLES

Definition and Classification

Epidemiology and Etiology

Pathophysiology

Risk Factors

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Vaccine-Induced Immune Thrombotic Thrombocytopenia

GENERAL PRINCIPLES

Thrombocytosis

GENERAL PRINCIPLES

5. Introduction to Coagulation and Laboratory Evaluation of Coagulation

INITIAL LABORATORY EVALUATION OF COAGULOPATHY

Preanalytical Variables

Complete Blood Count

Prothrombin Time/International Normalized Ratio

Activated Partial Thromboplastin Time

Thrombin Time

WORKUP OF ELEVATED PT OR aPTT

Isolated Prolonged aPTT

Prolonged PT

ADVANCED COAGULATION TESTING

Mixing Studies

Bethesda Assay

Factor Activity Assays

Studies of Platelet Function

LABORATORY EVALUATION OF SUSPECTED von WILLEBRAND DISEASE

Initial Diagnostic Approach

vWF Antigen Concentration (vWF:Ag)

vWF Activity Assays Ristocetin Cofactor Assay (vWF:RCo)

Ristocetin-Induced Platelet Aggregation (RIPA)

vWF Multimer Assay

Factor VIII Binding ELISA

PFA-100

LABORATORY EVALUATION OF SUSPECTED ANTIPHOSPHOLIPID ANTIBODY SYNDROME

INTERFERENCES OBSERVED BY COMMON ANTICOAGULANTS

6. Thrombotic Disease

Deep Venous Thrombosis and Pulmonary Embolus

GENERAL PRINCIPLES

Definition

Epidemiology

Prevention

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Medications

Other Nonpharmacologic Therapies

SPECIAL CONSIDERATIONS

COMPLICATIONS

Inherited Thrombophilia

GENERAL PRINCIPLES

Etiology

DIAGNOSIS

TREATMENT

Arterial Thromboembolism

GENERAL PRINCIPLES

Definition

Etiology

Risk Factors

DIAGNOSIS

Clinical Presentation

TREATMENT

Special Considerations

Hyperhomocysteinemia

GENERAL PRINCIPLES

Acquired Causes

DIAGNOSIS

TREATMENT

Antiphospholipid Syndrome

GENERAL PRINCIPLES

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

7. Coagulopathy

Hereditary Coagulopathy

von Willebrand Disease

GENERAL PRINCIPLES

Classification

Pathophysiology

DIAGNOSIS

Clinical Presentation

Differential Diagnosis

Diagnostic Testing

TREATMENT

Hemophilia A

GENERAL PRINCIPLES

DIAGNOSIS

Clinical Presentation

Diagnostic Criteria

Differential Diagnosis

TREATMENT

COMPLICATIONS

Hemophilia B

GENERAL PRINCIPLES

TREATMENT

FUTURE OF ANTIHEMOPHILIC THERAPIES

Acquired Coagulopathies

Acquired Hemophilia A

GENERAL PRINCIPLES

TREATMENT

Liver Disease

Vitamin K Deficiency

Disseminated Intravascular Coagulation

8. Bone Marrow Failure

Schwachman–Diamond Syndrome

GENERAL PRINCIPLES

Epidemiology

Classification

Pathophysiology

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

PROGNOSIS

Aplastic Anemia

GENERAL PRINCIPLES

Epidemiology

Classification

Etiology

Pathophysiology

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

PROGNOSIS

Paroxysmal Nocturnal Hemoglobinuria

GENERAL PRINCIPLES

Pathophysiology

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

PROGNOSIS

9. Myelodysplastic Neoplasms and Clonal Hematopoiesis

Clonal Hematopoiesis

GENERAL PRINCIPLES

Classification

Epidemiology

Pathophysiology

DIAGNOSIS

PROGNOSIS

TREATMENT

Clonal Cytopenia of Unknown Significance

GENERAL PRINCIPLES

Epidemiology

DIAGNOSIS

Classification

PROGNOSIS

TREATMENT

Myelodysplastic Neoplasms

GENERAL PRINCIPLES

Epidemiology

Classification

Pathophysiology

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

PROGNOSIS

VEXAS Syndrome

GENERAL PRINCIPLES

Clinical Presentation

TREATMENT

10. Myeloproliferative Neoplasms

Polycythemia Vera

GENERAL PRINCIPLES

Definition

Epidemiology

Etiology

Clinical Course

DIAGNOSIS

Clinical Presentation

Diagnostic Criteria

Differential Diagnosis

Diagnostic Testing

TREATMENT

Medications

SPECIAL CONSIDERATIONS

OUTCOME/PROGNOSIS

Essential Thrombocythemia

GENERAL PRINCIPLES

Definition

Epidemiology

Pathophysiology

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

SPECIAL CONSIDERATIONS

OUTCOME/PROGNOSIS

Primary Myelofibrosis

GENERAL PRINCIPLES

Definition

Epidemiology

DIAGNOSIS

Clinical Presentation

Diagnostic Criteria

Diagnostic Testing

TREATMENT

OUTCOME/PROGNOSIS

Hypereosinophilic Syndrome

GENERAL PRINCIPLES

Definition

Epidemiology

Pathophysiology

DIAGNOSIS

Clinical Presentation

Diagnostic Criteria

Diagnostic Testing

TREATMENT

OUTCOMES/PROGNOSIS

Mast Cell Disorders

GENERAL PRINCIPLES

Definition

Epidemiology

Pathophysiology

DIAGNOSIS

Clinical Presentation

Diagnostic Criteria

Diagnostic Testing

TREATMENT

SPECIAL CONSIDERATIONS

OUTCOMES/PROGNOSIS

11. Transfusion Medicine

INTRODUCTION

BLOOD BANKING

Donor Screening

Pretransfusion Testing

Blood Products

Blood Product Modifications

Blood Product Specifications

Transfusion Complications

APHERESIS

CELLULAR THERAPY LABORATORY

CONCLUSION

12. Sickle Cell Disease

Sickle Cell Disease

GENERAL PRINCIPLES

Epidemiology

Pathophysiology

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Chronic Management

SPECIAL CONSIDERATIONS

Surgery and Anesthesia

Dental Procedures

Transfusion Therapy

COMPLICATIONS

Hematologic Complications

Acute Painful Crisis

Infections

Neurologic Complications

Pulmonary Complications

Hepatobiliary Complications

Obstetric and Gynecologic Complications

Renal Complications

Priapism

Ocular Complications

Bone Complications

Dermatologic Complications

Cardiac Complications

13. Drugs That Affect Hemostasis: Anticoagulants, Thrombolytics, and Antifibrinolytics

Anticoagulants: Agents That Prevent Thrombosis

ANTIPLATELET DRUGS

Aspirin

Dipyridamole

P2Y12 Antagonist

Glycoprotein IIb/IIIa Antagonists

ANTICOAGULATION DRUGS

Warfarin

Unfractionated Heparin

Low–Molecular-Weight Heparin

Fondaparinux

Direct Thrombin Inhibitors

Dabigatran

Rivaroxaban

Apixaban

Edoxaban

Thrombolytics and Fibrinolytics: Agents That Disintegrate Clot

Coagulants: Agents that Treat Bleeding

DESMOPRESSIN

Mechanism of Action

Clinical Indications

Adverse Effects

VITAMIN K

Mechanism of Action

Preparation and Dosage

Clinical Indications

Adverse Effects

AMINOCAPROIC ACID

Mechanism of Action

Preparation and Dosage

Clinical Indications

Adverse Effects

PROTAMINE

Mechanism of Action

Preparation and Dosage

Clinical Indications

Adverse Effects

HUMATE-P

Mechanism of Action

Preparation and Dosage

Clinical Indications

Adverse Effects

RECOMBINANT COAGULATION FACTOR VIIA

Mechanism of Action

Preparation and Dosage

Clinical Indications

Adverse Effects

14. Plasma Cell Disorders

Monoclonal Gammopathy of Undetermined Significance

GENERAL PRINCIPLES

DIAGNOSIS

Clinical Presentation

Diagnostic Criteria

Diagnostic Testing

TREATMENT

PROGNOSIS

Multiple Myeloma

GENERAL PRINCIPLES

Epidemiology

DIAGNOSIS

Clinical Presentation

Diagnostic Criteria

Diagnostic Testing

TREATMENT

FOLLOW-UP

PROGNOSIS

Solitary Plasmacytoma

GENERAL PRINCIPLES

Epidemiology

DIAGNOSIS

Clinical Presentation

Diagnostic Criteria

Diagnostic Testing

TREATMENT

PROGNOSIS

Waldenström Macroglobulinemia

GENERAL PRINCIPLES

Epidemiology

DIAGNOSIS

Clinical Presentation

Diagnostic Criteria

Diagnostic Testing

TREATMENT

Immunoglobulin Light Chain Amyloidosis

GENERAL PRINCIPLES

Epidemiology

DIAGNOSIS

Clinical Presentation

Diagnostic Criteria

Diagnostic Testing

TREATMENT

PART II. ONCOLOGY

15. Introduction and Approach to Oncology

Approach to a Cancer Patient

GENERAL PRINCIPLES

Definition

Classification

Epidemiology

Pathophysiology

Risk Factors

DIAGNOSIS

Common Clinical Presentation

History

Physical Examination

Diagnostic Testing

TREATMENT

Approach to Oncology Treatment

Principles of Surgical Approach in Cancer

Principles of Radiation Therapy

Principles of Systemic Therapy

MONITORING/FOLLOW-UP

Response to Therapy

OUTCOME/PROGNOSIS

Goals of Care

Palliative Care

Hospice

16. Cancer Biology

HALLMARKS OF CANCER

GENETIC AND EPIGENETIC ALTERATIONS

Acquisition of Genetic Changes

Epigenetic Changes

Alterations in Oncogenes and Tumor Suppressor Genes

TUMOR METASTASIS

FUTURE DIRECTIONS

17. Introduction to Cancer Genomics

TYPES OF GENOMIC ALTERATIONS5,6

SEQUENCING TECHNOLOGIES

First Generation

Next-Generation Sequencing

Types of Sequencing

CANCER GENOME SEQUENCING1,3,5,7

APPLICATIONS

CLINICAL IMPACT OF NEXT-GENERATION SEQUENCING13,14

CHALLENGES

18. Cancer Therapeutics

GENERAL PRINCIPLES

19. Introduction to Radiation Oncology

PHYSICAL AND BIOLOGIC PRINCIPLES

RADIATION TREATMENT GOALS AND METHODS

INDICATIONS FOR URGENT RADIATION THERAPY

LATE EFFECTS AND TISSUE TOLERANCE

COMMON TREATMENT GUIDELINES AND ASSOCIATED ACUTE EFFECTS

Palliative Therapy

Bone Metastases

Lung Cancer

Esophageal Cancer

Central Nervous System Cancer

Head and Neck Cancer

Breast Cancer

Prostate Cancer

Colon/Rectal Cancer

Anal Cancer

Pediatric Cancer

Lymphoma

Total-Body Irradiation

Gynecologic Cancer

20. Introduction to Immunotherapy

GENERAL PRINCIPLES

CYTOKINES AND AGONISTS

BCG

VACCINES

Sipuleucel-T

Personalized Vaccines

CHECKPOINT BLOCKADE

CTLA-4 Blockade

PD-1/PD-L1 Blockade

LAG-3 Blockade

ADOPTIVE CELLULAR THERAPIES

Tumor-Infiltrating Lymphocytes (TIL)

Chimeric Antigen Receptors (CARs)

BISPECIFIC MOLECULES

CONCLUSION

21. Breast Cancer

GENERAL PRINCIPLES

Definition

Classification

Epidemiology

Risk Factors

Prevention

Screening

DIAGNOSIS

Clinical Presentation

Differential Diagnosis

Diagnostic Testing

TREATMENT

Noninvasive Carcinoma/Carcinoma In Situ

Early Breast Cancer

Hormone Receptor Positive (HR+) Disease

HER2-Positive Disease

Triple-Negative Breast Cancer (TNBC)

Inflammatory Breast Cancer

Metastatic Breast Cancer

MONITORING/FOLLOW-UP

22. Lung Cancer

Non–Small-Cell Lung Cancer

GENERAL PRINCIPLES

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

Staging

TREATMENT

Early-Stage Node-Negative Disease

Early-Stage Node-Positive Disease

Locally Advanced Disease

Metastatic Disease

MONITORING/FOLLOW-UP

OUTCOME/PROGNOSIS

Small-Cell Lung Cancer

GENERAL PRINCIPLES

DIAGNOSIS

Clinical Presentation

TREATMENT

MONITORING/FOLLOW-UP

OUTCOME/PROGNOSIS

Other Malignant Tumors of the Lung

23. Colorectal Cancer

Colorectal Cancer

GENERAL PRINCIPLES

Epidemiology

Pathophysiology

Risk Factors

Prevention/Screening

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Treatment of Rectal Cancer

COMPLICATIONS

Tumor Related

Treatment Related

MONITORING/FOLLOW-UP

OUTCOMES/PROGNOSIS

Anal Cancer

GENERAL PRINCIPLES

Epidemiology

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

Staging

TREATMENT

OUTCOME/PROGNOSIS

24. Other Gastrointestinal Malignancies

Esophageal Cancer

GENERAL PRINCIPLES

Definition

Classification

Epidemiology

Etiology and Pathophysiology

Risk Factors

Prevention

Associated Conditions

DIAGNOSIS

Clinical Presentation

Diagnostic Criteria

Differential Diagnosis

Diagnostic Testing

TREATMENT

Other Nonpharmacologic Therapies

Lifestyle/Risk Modification

COMPLICATIONS

REFERRAL

MONITORING/FOLLOW-UP

OUTCOME/PROGNOSIS

Gastric Cancer

GENERAL PRINCIPLES

Definition

Classification

Epidemiology

Etiology and Pathophysiology

Risk Factors

Prevention

DIAGNOSIS

Clinical Presentation

Diagnostic Criteria

Differential Diagnosis

Diagnostic Testing

TREATMENT

Gastrointestinal Stromal Tumor (GIST)

SPECIAL CONSIDERATIONS

COMPLICATIONS

MONITORING/FOLLOW-UP

OUTCOME/PROGNOSIS

Pancreatic Cancer

GENERAL PRINCIPLES

Definition

Classification

Epidemiology

Etiology and Pathophysiology

Risk Factors

Associated Conditions

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Lifestyle/Risk Modification

SPECIAL CONSIDERATIONS

COMPLICATIONS

MONITORING/FOLLOW-UP

OUTCOME/PROGNOSIS

Hepatocellular Carcinoma

GENERAL PRINCIPLES

Definition

Epidemiology

Etiology and Pathophysiology

Risk Factors

Prevention

Associated Conditions

DIAGNOSIS

Clinical Presentation

Diagnostic Criteria

Differential Diagnosis

Diagnostic Testing

TREATMENT

COMPLICATIONS

MONITORING/FOLLOW-UP

OUTCOME/PROGNOSIS

Gallbladder Cancer

GENERAL PRINCIPLES

Classification

Epidemiology

Risk Factors

Prevention

Associated Conditions

DIAGNOSIS

Clinical Presentation

Diagnostic Criteria

Differential Diagnosis

Diagnostic Testing

TREATMENT

COMPLICATIONS

MONITORING/FOLLOW-UP

OUTCOME/PROGNOSIS

Cholangiocarcinoma

GENERAL PRINCIPLES

Definition

Classification

Epidemiology

Etiology and Pathophysiology

Risk Factors

DIAGNOSIS

Clinical Presentation

Diagnostic Criteria

Differential Diagnosis

Diagnostic Testing

TREATMENT

COMPLICATIONS

MONITORING/FOLLOW-UP

OUTCOME/PROGNOSIS

25. Malignant Melanoma

GENERAL PRINCIPLES

Definition

Classification

Epidemiology

Risk Factors

Prevention

DIAGNOSIS

Clinical Presentation

Staging

TREATMENT

Local and Locoregional Disease (Stage I–III)

Unresectable or Metastatic Disease (Stage IV)

SPECIAL SITUATIONS IN MELANOMA

26. Head and Neck Cancer

Squamous Cell Carcinoma of the Head and Neck

GENERAL PRINCIPLES

Epidemiology

Pathophysiology

Risk Factors

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

COMPLICATIONS

MONITORING/FOLLOW-UP

Nasopharyngeal Carcinoma

GENERAL PRINCIPLES

Epidemiology

Risk Factors

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Salivary Gland Tumors

GENERAL PRINCIPLES

TREATMENT

27. Sarcoma

Soft Tissue Sarcomas

DIAGNOSIS

Clinical Presentation

Differential Diagnosis

Diagnostic Testing

TREATMENT

Early-Stage Disease (Stages I–III)

Stage IV Metastatic Soft Tissue Sarcomas

PROGNOSIS

Bone Sarcomas

GENERAL PRINCIPLES

Classification

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

28. Endocrine Malignancies

Thyroid Carcinoma

GENERAL PRINCIPLES

Epidemiology

Risk Factors

DIAGNOSIS

Clinical Presentation

Physical Examination

Diagnostic Testing

TREATMENT

FOLLOW-UP

PROGNOSIS

Parathyroid Carcinoma

GENERAL PRINCIPLES

DIAGNOSIS

TREATMENT

PROGNOSIS

Pituitary Neoplasms

GENERAL PRINCIPLES

Epidemiology

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Prolactin-Secreting Adenomas

Growth Hormone–Secreting Adenomas

Adrenal Corticotrophin Hormone–Secreting Adenomas

Gonadotropin-Secreting Adenomas and Nonsecreting Pituitary Adenomas

TSH-Secreting Adenomas

Adrenal Tumors: Pheochromocytoma, Paraganglioma, and Adrenocortical Tumors

GENERAL PRINCIPLES

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Adjuvant Therapy for Resected Disease

Systemic Treatment for Unresectable Disease

PROGNOSIS

Pheochromocytoma

GENERAL PRINCIPLES

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Diffuse Endocrine System Tumors

Nonfunctioning Gastroenteropancreatic Neuroendocrine Tumors

GENERAL PRINCIPLES

DIAGNOSIS

Clinical Presentation

TREATMENT

Functioning Neuroendocrine Tumors

GENERAL PRINCIPLES

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Genetic Predisposition Syndromes

29. Urologic Malignancies

Prostate Cancer

GENERAL PRINCIPLES

Risk Factors

Prevention

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Renal Cell Carcinoma

GENERAL PRINCIPLES

Epidemiology

Risk Factors

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Testicular Cancer

GENERAL PRINCIPLES

Classification

Epidemiology

Risk Factors

DIAGNOSIS

Clinical Presentation

TREATMENT

MONITORING/FOLLOW-UP

Bladder Cancer

GENERAL PRINCIPLES

Epidemiology

Risk Factors

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

30. Gynecologic Oncology

Vaginal Bleeding

GENERAL PRINCIPLES

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Medications

Surgical Management

Pelvic Masses

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Cervical Cancer

GENERAL PRINCIPLES

Classification

Epidemiology

Risk Factors

Prevention

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Radiation Therapy

Chemotherapy

Surgical Management

Treatment for Recurrent Disease

MONITORING/FOLLOW-UP

OUTCOME/PROGNOSIS

Ovarian Cancer

GENERAL PRINCIPLES

Classification

Epidemiology

Risk Factors

Prevention

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Surgical Management

Chemotherapy and Biologics

Neoadjuvant and Maintenance Chemotherapy

Treatment for Recurrent Disease

MONITORING/FOLLOW-UP

OUTCOME/PROGNOSIS

Endometrial Cancer

GENERAL PRINCIPLES

Classification and Risk Factors

Epidemiology

Prevention

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Surgical Management

Radiation Therapy

Chemotherapy and Biologics

Treatment for Recurrent Disease

MONITORING/FOLLOW-UP

OUTCOME/PROGNOSIS

Uterine Sarcomas

GENERAL PRINCIPLES

Classification and Risk Factors

Epidemiology

Prevention

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Surgical Management

Radiation Therapy

Chemotherapy and Biologics

Treatment for Advanced/Recurrent Disease

MONITORING/FOLLOW-UP

OUTCOME/PROGNOSIS

Gestational Trophoblastic Disease

GENERAL PRINCIPLES

Classification

Epidemiology

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

MONITORING/FOLLOW-UP

OUTCOME/PROGNOSIS

Gestational Trophoblastic Neoplasia

GENERAL PRINCIPLES

Classification

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Surgical Management

Chemotherapy

MONITORING/FOLLOW-UP

OUTCOME/PROGNOSIS

31. Primary Brain Tumors

Grade 4 Gliomas

GENERAL PRINCIPLES

Imaging

Classification

Key Molecular Features

TREATMENT

PROGNOSIS

Grade 2–3 Gliomas

GENERAL PRINCIPLES

Classification

Imaging

TREATMENT

PROGNOSIS

Meningiomas

GENERAL PRINCIPLES

Imaging

Pathology/Classification

TREATMENT

PROGNOSIS

Other Tumor Types

32. Leukemias

Acute Leukemias

Acute Myeloid Leukemia

GENERAL PRINCIPLES

Definition

Classification

Epidemiology

Risk Factors

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

COMPLICATIONS

PROGNOSIS

Acute Promyelocytic Leukemia

GENERAL PRINCIPLES

Definition

Epidemiology

Risk Factors

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

COMPLICATIONS

PROGNOSIS

Acute Lymphoblastic Leukemia

GENERAL PRINCIPLES

Definition

Classification

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

MONITORING/FOLLOW-UP

PROGNOSIS

Chronic Leukemias

Chronic Myeloid Leukemia

GENERAL PRINCIPLES

Epidemiology

Etiology

Pathophysiology

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Chronic-Phase Chronic Myeloid Leukemia

Accelerated and Blast-Phase Chronic Myeloid Leukemia

MONITORING/FOLLOW-UP

Chronic Lymphocytic Leukemia

GENERAL PRINCIPLES

Classification

Epidemiology

Pathophysiology

Risk Factors

DIAGNOSIS

Clinical Presentation

Diagnostic Criteria

Differential Diagnosis

Diagnostic Testing

TREATMENT

COMPLICATIONS

PROGNOSIS

Hairy Cell Leukemia

GENERAL PRINCIPLES

PATHOPHYSIOLOGY

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

OUTCOME/PROGNOSIS

33. Lymphoma

Hodgkin Lymphoma

BACKGROUND AND EPIDEMIOLOGY

CLINICAL PRESENTATION

DIAGNOSIS AND STAGING

CLASSICAL HODGKIN LYMPHOMA TREATMENT

CLASSICAL HODGKIN LYMPHOMA FOLLOW-UP

NLPHL TREATMENT AND FOLLOW-UP

Non-Hodgkin Lymphoma

BACKGROUND AND EPIDEMIOLOGY

CLINICAL PRESENTATION

DIAGNOSIS AND STAGING

FOLLICULAR LYMPHOMA TREATMENT

DIFFUSE LARGE B-CELL LYMPHOMA TREATMENT

FOLLOW-UP

Other Non-Hodgkin Lymphomas

34. Introduction to Hematopoietic Stem Cell Transplantation

INTRODUCTION

PATIENT SELECTION AND ELIGIBILITY

Indications for Transplant

Patient Eligibility and Pretransplant Evaluation

SOURCES OF STEM CELLS

Bone Marrow

Peripheral Blood

Umbilical Cord Blood

TYPES OF TRANSPLANTS

Autologous HSCT

Syngeneic HSCT

Allogeneic HSCT

DONOR SELECTION FOR ALLOGENEIC HSCT

HLA Typing

HLA Matching

Other Factors

CONDITIONING REGIMENS

Myeloablative Conditioning

Reduced-Intensity Regimens

HEMATOPOIETIC STEM CELL INFUSION

POSTTRANSPLANT CARE AND COMPLICATIONS

Engraftment

Engraftment Syndrome

Graft Failure

Blood Group Incompatibility

Graft-Versus-Host Disease

Infections

Gastrointestinal Complications

Noninfectious Pulmonary Complications

Thrombotic Microangiopathy (TMA)

Neurologic Toxicity

Late Complications in Long-Term Survivors

CELLULAR THERAPY

TOXICITY OF CELLULAR THERAPY

35. Human Immunodeficiency Virus–Associated Malignancies

Kaposi Sarcoma

GENERAL PRINCIPLES

Epidemiology

Pathophysiology

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

PROGNOSIS

TREATMENT

HIV-Associated Lymphomas

GENERAL PRINCIPLES

Epidemiology

Pathophysiology

Non-Hodgkin Lymphoma

GENERAL PRINCIPLES

Classification and Clinical Presentation

DIAGNOSIS

TREATMENT

PROGNOSIS

Hodgkin Lymphoma

HPV-Associated Cancers

Cervical Cancer

Anal Cancer

Other Cancers

Treatment Monitoring for PWH Receiving Cancer Treatment

Immunotherapy and Cellular Therapy

36. Cancer of Unknown Primary (CUP)

GENERAL PRINCIPLES

Definition

Classification Based on Histologic Subtype

Epidemiology

Etiology

Pathophysiology

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

SPECIAL CONSIDERATIONS

MONITORING/FOLLOW-UP

OUTCOME/PROGNOSIS

37. Supportive Care in Oncology

Management by Physical Symptom

Pain Management

GENERAL PRINCIPLES

Definition

DIAGNOSIS

TREATMENT

Medications

Constipation

GENERAL PRINCIPLES

DIAGNOSIS

TREATMENT

Diarrhea

GENERAL PRINCIPLES

DIAGNOSIS

TREATMENT

Nausea and Vomiting

GENERAL PRINCIPLES

DIAGNOSIS

TREATMENT

Mucositis

GENERAL PRINCIPLES

DIAGNOSIS

TREATMENT

Anorexia and Cachexia

GENERAL PRINCIPLES

DIAGNOSIS

TREATMENT

Dyspnea

GENERAL PRINCIPLES

DIAGNOSIS

TREATMENT

Anemia

GENERAL PRINCIPLES

DIAGNOSIS

TREATMENT

Emotional Symptom Management

GENERAL PRINCIPLES

DIAGNOSIS

TREATMENT

Anxiety

DIAGNOSIS

TREATMENT

Delirium

GENERAL PRINCIPLES

DIAGNOSIS

TREATMENT

Insomnia

DIAGNOSIS

TREATMENT

Addressing Spiritual Care

38. Oncologic Emergencies

Neutropenic Fever

GENERAL PRINCIPLES

DEFINITION

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Medications

Other Nonpharmacologic Therapies

Epidural Spinal Cord Compression

GENERAL PRINCIPLES

ETIOLOGY

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Malignant Pericardial Effusion and Tamponade

GENERAL PRINCIPLES

Pathophysiology

DIAGNOSIS

Clinical Presentation

Differential Diagnosis

Diagnostic Testing

TREATMENT

Superior Vena Cava Syndrome

GENERAL PRINCIPLES

Definition

Etiology

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Tumor Lysis Syndrome

GENERAL PRINCIPLES

DIAGNOSIS

Clinical Presentation

TREATMENT

Hypercalcemia of Malignancy

GENERAL PRINCIPLES

Etiology

DIAGNOSIS

Clinical Presentation

Diagnostic Testing

TREATMENT

Syndrome of Inappropriate Antidiuresis and Hyponatremia

GENERAL PRINCIPLES

Etiology

DIAGNOSIS

Clinical Presentation

TREATMENT

Other Neurologic Emergencies

Index

 

An aparitie	23 noi 2024
Autor	Brian A. Van Tine MD
Dimensiuni	127 x 203 x 23 mm
Editura	LWW
Format	Paperback
ISBN	9781975212841
Limba	Engleza
Nr pag	575