Williams Manual of Hematology, Tenth Edition

Description:

A full-color clinical reference covering both common and uncommon blood disorders—distilled from the world’s leading hematology text Williams Manual of Hematology, Tenth Edition provides a concise, easy-to-navigate compilation of the pathogenic, diagnostic, and therapeutic essentials of blood cell and coagulation protein disorders. Referenced to the classic Williams Hematology, this portable guide has been carefully edited to deliver only the most clinical point-of-care facts, making differential diagnosis faster, easier, and more efficient. This updated edition reflects the latest research and includes more than 100 full-color clinical photographs. Concise but comprehensive, this complete guide includes sections on: Initial Clinical Evaluation Disorders of Red Cells Disorders of Granulocytes Disorders of Monocytes and Macrophages Principles of Therapy for Neoplastic Hematological Disorders The Clonal Myeloid Disorders The Polyclonal Lymphoid Diseases The Clonal Lymphoid and Plasma Cell Diseases Disorders of Platelet and Hemostasis Disorders of Coagulation Proteins Thrombosis and Antithrombotic Therapy Transfusion and Hemapheresis

Table of Contents:

Part I. Initial Clinical Evaluation

1. Approach to the Patient

Part II. Disorders of Red Cells

2. Classification of Anemias and Erythrocytoses

3. Aplastic Anemia: Acquired and Inherited

4. Pure Red Cell Aplasia

5. Anemia of Chronic (Inflammatory, Neoplastic, and Renal) Disease

6. Erythropoietic Effects of Endocrine Disorders

7. Congenital Dyserythropoietic Anemias

8. Folate, Cobalamin, and Megaloblastic Anemias

9. Iron Deficiency and Iron Overload

10. Anemia Resulting from Other Nutritional Deficiencies

11. Hereditary and Acquired Sideroblastic Anemias

12. Anemia Resulting from Marrow Infiltration

13. Erythrocyte Membrane Disorders

14. Hemolytic Anemia Related to Red Cell Enzyme Defects

15. The Thalassemias

16. The Sickle Cell Diseases and Other Hemoglobinopathies

17. Unstable Hemoglobins and Hemoglobins with Altered Oxygen Affinity

18. Methemoglobinemia and Other Dyshemoglobinemias

19. Fragmentation Hemolytic Anemia

20. Hemolytic Anemia Resulting from a Chemical or Physical Agent

21. Hemolytic Anemia Resulting from Infectious Agents

22. Hemolytic Anemia Resulting from Warm-Reacting Antibodies

23. Cryopathic Hemolytic Anemia

24. Drug-Induced Hemolytic Anemia

25. Alloimmune Hemolytic Disease of the Newborn

26. Hypersplenism and Hyposplenism

27. Polyclonal Erythrocytoses (Primary and Secondary)

28. The Porphyrias

Part III. Disorders of Granulocytes

29. Classification and Clinical Manifestations of Neutrophil Disorders

30. Neutropenia and Neutrophilia

31. Disorders of Neutrophil Function

32. Eosinophils and Their Disorders

33. Basophils, Mast Cells and Their Disorders

Part IV. Disorders of Monocytes and Macrophages

34. Classification and Clinical Manifestations of Monocyte and Macrophage Disorders

35. Monocytosis and Monocytopenia

36. Inflammatory and Malignant Histiocytosis

37. Gaucher Disease and Related Lysosomal Storage Diseases

Part V. Principles of Therapy for Neoplastic Hematologic Disorders

38. Pharmacology and Toxicity of Antineoplastic Drugs

39. Principles of Hematopoietic Cell Transplantation

40. Immune Cell Therapy: Genetically Engineered T Cells

Part VI. The Clonal Myeloid Disorders

41. Classification and Clinical Manifestations of the Clonal Myeloid Disorders

42. Polycythemia Vera

43. Essential Thrombocythemia

44. Paroxysmal Nocturnal Hemoglobinuria

45. Myelodysplastic Syndromes

46. The Acute Myelogenous Leukemias

47. The Chronic Myelogenous Leukemias

48. Primary Myelofibrosis

Part VII. The Polyclonal Lymphoid Diseases

49. Classification and Clinical Manifestations of Polyclonal Lymphocyte and Plasma Cell Disorders

50. Lymphocytosis and Lymphocytopenia

51. Primary Immunodeficiency Syndrome

52. Hematologic Manifestations of the Acquired Immunodeficiency Syndrome

53. The Mononucleosis Syndromes

Part VIII. The Clonal Lymphoid and Plasma Cell Diseases

54. Classification and Clinical Manifestations of the Neoplastic Lymphocytic Disorders

55. The Acute Lymphoblastic Leukemias

56. The Chronic Lymphocytic Leukemias

57. Hairy Cell Leukemia

58. Large Granular Lymphocytic Leukemia

59. General Considerations of Lymphoma: Epidemiology, Etiology, Heterogeneity, and Primary Extranodal Disease

60. Hodgkin Lymphoma

61. Diffuse Large B-Cell Lymphoma and Related Diseases

62. Follicular Lymphoma

63. Mantle Cell Lymphoma

64. Marginal Zone B-Cell Lymphoma

65. Burkitt Lymphoma

66. Cutaneous T-Cell Lymphoma

67. Mature T-Cell and Natural Killer Cell Lymphomas

68. Essential Monoclonal Gammopathy

69. Myeloma

70. Macroglobulinemia

71. Heavy-Chain Diseases

72. Amyloidosis

Part IX. Disorders of Platelets and Hemostasis

73. Clinical Manifestations, Evaluation and Classification of Disorders of Hemostasis

74. Thrombocytopenia

75. Hereditary and Reactive (Secondary) Thrombocytosis

76. Hereditary Platelet Disorders

77. Acquired Platelet Disorders

78. The Vascular Purpuras

Part X. Disorders of Coagulation Proteins

79. Hemophilia A and B

80. von Willebrand Disease

81. Hereditary Disorders of Fibrinogen

82. Inherited Deficiencies of Coagulation Factors II, V, VII, X, XI, and XIII and Combined Deficiencies of Factor V and VIII and of Vitamin K–Dependent Factors

83. Antibody-Mediated Coagulation Factor Deficiencies

84. Hemostatic Dysfunction Related to Liver Diseases

85. The Antiphospholipid Syndrome

86. Disseminated Intravascular Coagulation

87. Fibrinolysis and Thrombolysis

Part XI. Thrombosis and Antithrombotic Therapy

88. Principles of Antithrombotic and Antifibrinolytic Therapy

89. Hereditary Thrombophilia

90. Venous Thromboembolism

91. Antibody-Mediated Thrombotic Disorders: Thrombotic Thrombocytopenic Purpura and Heparin-Induced Thrombocytopenia

Part XII. Transfusion and Hemapheresis

92. Red Cell Transfusion

93. Transfusion of Platelets

94. Plasma and Plasma Component Therapy

95. Therapeutic Hemapheresis

Table of Normal Values

Index