Antiphospholipid Antibody Syndrome. From Bench to Bedside

• Provides up-to-date knowledge on the pathogenesis and management of the syndrome
• Presents and discusses innovative treatments in addition to standard treatment options
• Describes the involvement of other organs or organ systems

About this book

This book, part of the series Rare Diseases of the Immune System, offers comprehensive, up-to-date coverage of the pathophysiology and management of the antiphospholipid syndrome (APS). Immunologic and genetic aspects are discussed and the pathogenic mechanisms responsible for such phenomena as APS-mediated thrombosis and pregnancy loss/complications are explained.

The main clinical manifestations, classification criteria and diagnostic tools are identified, and close attention is paid to the nature of the involvement of various organs or organ systems in APS. Specific chapters describe the treatment of the different symptoms, therapies of value in avoiding recurrences, and innovative treatment approaches. The authors are senior experts in the field who are aided by younger fellows, ensuring that the book is also educationally oriented. This handy volume will be a valuable tool for postgraduates in training and professionals wishing to extend their knowledge of this specific syndrome.

Reviews

From the book reviews:

“The purpose is to provide an overview of this very difficult subject that will benefit bench researchers as well as bedside clinicians. The book would serve any audience who wants to know more about antiphospholipid syndrome. … This is an excellent, up-to-date overview of antiphospholipid syndrome. It will serve as a handy tool to get more information on the topic.” (Dany V. Thekkemuriyil, Doody’s Book Reviews, February, 2015)

Table of contents (20 chapters)

·         Genetics and Origin of Antiphospholipid Syndrome

Soriano, Alessandra (et al.)

Pages 1-12

·         The Paradox of Lupus Anticoagulant

Banzato, Alessandra (et al.)

Pages 13-23

·         Antiphospholipid Antibody Mechanisms of Thrombosis

Meroni, Pier Luigi (et al.)

Pages 25-35

·         The Pathogenic Mechanisms for Antiphospholipid Antibodies (aPL)-Mediated Pregnancy Loss

Simone, Nicoletta (et al.)

Pages 37-46

·         Classification Criteria for the Antiphospholipid Syndrome

Derksen, Ronald H. W. M. (et al.)

Pages 47-59

·         Non-classification Criteria

Gerosa, Maria (et al.)

Pages 61-74

·         Obstetric APS

Fredi, Micaela (et al.)

Pages 75-87

·         APS and the Nervous System

Chighizola, Cecilia Beatrice (et al.)

Pages 89-102

·         Antiphospholipid Syndrome (APS) and the Renal Involvement

Mezzina, Nicoletta (et al.)

Pages 103-112

·         Non-Thrombotic Hematologic Manifestations in APS

Barcellini, Wilma (et al.)

Pages 113-126

·         Heart and APS

Denas, Gentian (et al.)

Pages 127-150

·         Skin Involvement in Antiphospholipid Syndrome

Marzano, Angelo Valerio (et al.)

Pages 151-161

·         Additional Organs Involved in Antiphospholipid Syndrome: Eye, Ear-Nose-Throat, Lung, Gastroenteric System, Endocrine Glands

Santis, Maria (et al.)

Pages 163-168

·         Differential Diagnosis

Prisco, Domenico (et al.)

Pages 169-184

·         Treatment of Thrombosis in Antiphospholipid Syndrome

Braham, Simon (et al.)

Pages 185-192

·         Treatment of Pregnancy Complications

Acaia, Barbara (et al.)

Pages 193-206

·         Antiphospholipid Antibody Carriers

Dall’Ara, Francesca (et al.)

Pages 207-218

·         New Treatments

Chighizola, Cecilia Beatrice (et al.)

Pages 219-232

·         Secondary Antiphospholipid Syndrome

Rahman, Anisur (et al.)

Pages 233-248

·         The

Rodríguez-Pintó, Ignasi (et al.)

Pages 249-262