Atlas of Rheumatoid Arthritis

Description:

Atlas of Rheumatoid Arthritis is a high-quality educational initiative, written by leaders in the field of rheumatology, containing a collection of approximately 150 relevant images, with extended descriptive captions and a comprehensive bibliography. The Atlas of Rheumatoid Arthritis will provide clinicians with a visual guide to rheumatoid arthritis, focusing on assessment, diagnosis and treatment, including newer research into the signalling pathways involved in the pathogenesis of RA, before focusing on the treatment of RA. Rheumatoid arthritis (RA) is the most common and most serious of the inflammatory arthritic disorders, and it dominates clinical rheumatological practice. Effective, early treatment is vital as this can slow the course of the disease and reduce joint damage. RA is usually treated using disease-modifying anti-rheumatic drugs (DMARDs), most commonly methotrexate. The newest treatments target the disease-causing immune elements specifically and directly.

Table of Contents:

PART ONE Rheumatoid arthritis overview

1 Classification of rheumatoid arthritis

References

2 Pre- rheumatoid arthritis

What is pre-rheumatoid arthritis?

Risk factors for rheumatoid arthritis

Systemic autoimmunity associated with rheumatoid arthritis

Symptoms without clinical arthritis

Unclassified arthritis

References

3 Early rheumatoid arthritis

Introduction

Pathology in early rheumatoid arthritis

Diagnosis of early rheumatoid arthritis

Classification of rheumatoid arthritis

Management of early rheumatoid arthritis

Recommendations for the management of early rheumatoid arthritis

References

4 Established rheumatoid arthritis

Introduction

Stages of established rheumatoid arthritis

Common clinical presentations

References

5 Remission and rheumatoid arthritis

Introduction

Defining remission

Imaging remission

Immune-mediated remission

Drug-free remission

Optimal dose reduction regimes for patients in remission

References

PART TWO Imaging of rheumatoid arthritis

6 Magnetic resonance imaging in rheumatoid arthritis

Introduction

Technical aspects

Visualizing rheumatoid arthritis

Diagnosing rheumatoid arthritis

Monitoring disease activity and structural damage

References

7 Ultrasound imaging in rheumatoid arthritis

Introduction

Ultrasound and rheumatoid arthritis

Cartilage damage

Management of rheumatoid arthritis with ultrasound: diagnosis,therapeutic follow-up, remission, and

Conclusion

References

8 Dual energy X-ray absorptiometry in rheumatoid arthritis

Introduction

Bone remodeling in rheumatoid arthritis

Bone damage imaging in rheumatoid arthritis

Treatment of bone loss in rheumatoid arthritis

References

PART THREE Treatment of rheumatoid arthritis

9 Methotrexate

Introduction

Historical perspective

Mechanism of action and pharmacokinetics

Dosing

Benefits

Monitoring

Side effects

References

10 Immunotherapy

Introduction

Nonbiologic disease-modifying antirheumatic drugs

Biologic disease-modifying antirheumatic drugs

Cost-effectiveness of immunotherapy in early rheumatoid arthritis

Recommendations for the use of disease-modifying antirheumatic drug therapies

Safety of immunotherapy

Prospective new targets for immunotherapy

References

11 Rituximab

B-cell development and differentiation

Efficacy of rituximab in rheumatoid arthritis

12 Novel therapies in rheumatoid arthritis: small molecules

Introduction

Inhibiting intracellular signaling pathways

Conclusion