Oxford Textbook of Sjögren’s Syndrome (Oxford Textbooks in Rheumatology)

Description:

Sjögren's syndrome is a chronic autoimmune disease which can cause debilitating fatigue and pain. Diagnosis is often challenging due to the variability of symptoms and severity, and a multidisciplinary approach to management and treatment is required, yet there are few comprehensive resources covering everything clinicians need to know. The Oxford Textbook of Sjögren's Syndrome bridges this gap by offering extensive coverage of system by system manifestations and treatments, as well as practical, evidence-based advice on diagnosing and managing this condition. Bringing together recent advances in research and therapies, this up-to-date guide covers everything clinicians need to know from the fundamental science and clinical characteristics of this condition, to the immunological and biochemical aspects, investigative procedures such as biopsy techniques and imaging modalities, and pharmacological and non-pharmacological interventions.

Table of Contents:

Section 1 Introduction

1.1 Introduction

1.2 Historical background, classification, and diagnostic criteria

1.3 Epidemiology and genetics of Sjögren’s syndrome

Section 2 Basic science

2.1 Biomarkers in primary Sjögren’s syndrome

2.2 Autoantibodies and autoantigens in Sjögren’s syndrome

2.3 Stromal cells in Sjögren’s syndrome

Section 3 Diagnostic investigations

3.1 Clinical assessment of salivary glands function

3.2 Salivary gland biopsy—procedure and histopathology

3.3 Imaging in Sjögren’s syndrome

Section 4 Head and neck manifestations and clinical management

4.1 Salivary gland manifestations and management

4.2 Oral manifestations and management

4.3 Dental-related disease

Section 5 Ocular manifestations and management

5.1 Ocular manifestations of Sjögren’s syndrome

5.2 A therapeutic strategy for Sjögren’s syndrome dry eye

Section 6 Systemic manifestations

6.1 Cutaneous involvement and management of Sjögren’s syndrome

6.2 Musculoskeletal disease—presentation and management

6.3 Renal involvement in primary Sjögren’s syndrome

6.4 Gastrointestinal disease in Sjögren’s syndrome

6.5 Neurological complications of Sjögren’s syndrome

6.6 Cardiovascular and lung manifestations of Sjögren’s syndrome

6.7 Haematological manifestations of Sjögren’s syndrome

6.8 Fatigue in Sjögren’s syndrome

6.9 Nonpharmacological interventions for the management of fatigue and constitutional symptoms in Sjögren’s syndrome

6.10 Gynaecologic and obstetric aspects in Sjögren’s syndrome

6.11 Sjögren’s syndrome–associated lymphoma

Section 7 Juvenile and young adult

7.1 Juvenile- and young adult–onset Sjögren’s syndrome

Section 8 Sjögren’s mimics and overlaps

8.1 Mimics of Sjögren’s syndrome

8.2 Sjögren’s syndrome overlaps

Section 9 Experimental treatments, emerging therapies, and the future

9.1 Experimental therapies in primary Sjögren’s syndrome

9.2 Sjögren’s syndrome—summary of clinical management

Index