Pediatric Rheumatology Comes of Age: Part I, An Issue of Rheumatic Disease Clinics of North America

Description:

This issue of Rheumatic Disease Clinics, guest edited by Drs. Laura Schanberg and Yukiko Kimura, will focus on Pediatric Rheumatology. This issue is one of four selected each year by our series Consulting Editor, Dr. Michael Weisman. Part II, also edited by Drs. Kimura and Schanberg, will publish subsequently and cover additional topics relevant for pediatric rheumatologists. Topics discussed in this issue include but are not limited to: TMJ, CNO (CRMO), Update JIA treatment, Pharmacology of biologics in kids, Juvenile Spondylitis, Juvenile fibro update, JDM update, Pediatric Sjogrens, Localized scleroderma, Systemic Sclerosis, Uveitis, COVID-19 in pediatrics, Recent advances in pediatric vasculitis, and Autoinflammatory diseases.

Provides in-depth, clinical reviews on the latest updates in Pediatric Rheumatology, providing actionable insights for clinical practice.

Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Table of Contents:

CARRA: The Childhood Arthritis and Rheumatology Research Alliance

Key points

The Childhood Arthritis & Rheumatology Research Alliance: The beginning (2000–2007)

The early growth years: 2006 to 2012

Carra, Inc., and the new Carra (2015–present)

Evolution and challenges

The future of the Childhood Arthritis & Rheumatology Research Alliance

Clinics care points

Juvenile Idiopathic Arthritis Treatment Updates

Key points

Introduction

Juvenile idiopathic arthritis: Oligoarthritis and polyarthritis

Enthesitis-related arthritis and juvenile psoriatic arthritis

Systemic juvenile idiopathic arthritis

Clinics care points

Recent Updates in Juvenile Spondyloarthritis

Key points

Introduction

Classification

Clinical features

Genetic susceptibility and pathogenesis

Diagnostic imaging

Disease activity measures

Treatment

Summary

Clinics care points

Disclosure

Pathogenesis and Treatment of Refractory Disease Courses in Systemic Juvenile Idiopathic Arthritis: Refractory Arthritis, Recurrent Macrophage Activation Syndrome and Chronic Lung Disease

Key points

Introduction

The need for defining refractory disease courses in systemic juvenile idiopathic arthritis

Refractory systemic juvenile idiopathic arthritis course I: refractory arthritis

Therapeutic strategies for refractory arthritis in systemic juvenile idiopathic arthritis

Refractory systemic juvenile idiopathic arthritis course II: recurrent macrophage activation syndrome

Refractory systemic juvenile idiopathic arthritis course III: systemic juvenile idiopathic arthritis–associated lung disease

Summary and future directions

Clinics care points

The Temporomandibular Joint in Juvenile Idiopathic Arthritis

Key points

Introduction

Juvenile idiopathic arthritis-associated temporomandibular joint terminology

Repercussions of temporomandibular joint involvement in juvenile idiopathic arthritis

Clinical signs and symptoms of temporomandibular joint arthritis

Imaging of temporomandibular joint arthritis

Local and systemic treatment

Orthopedic devices and surgery

Summary

Clinics care points

Uveitis in Children and Adolescents

Key points

Overview

Common uveitis syndromes

Ocular complications

Ophthalmic work-up

Therapeutic options

Treatment withdrawal

Summary

Clinics care points

Pharmacosurveillance in Juvenile Idiopathic Arthritis

Key points

Introduction

Pharmacosurveillance

Spontaneous reporting systems

Big data

Electronic health records

Administrative claims data

Registries

Drug-specific registries

Multidrug registries

Disease-specific registries

Assessing medication safety in juvenile idiopathic arthritis

Infections

Malignancies

Future challenges

Outcome Measures in Pediatric Rheumatic Disease

Key points

Outcome measures in pediatric rheumatic disease

Outcome measures in juvenile idiopathic arthritis

Outcome measures in juvenile dermatomyositis

Outcome measures in childhood-onset lupus

Outcome measures in vasculitis

Future directions

Clinics care points

Updates on Juvenile Dermatomyositis from the Last Decade: Classification to Outcomes

Key points

Introduction

Classification

Serologic classification of juvenile dermatomyositis

Assessment

Pathogenesis

Treatment

Long-term outcomes

Summary

Clinics care points

Disclosure

Chronic Nonbacterial Osteomyelitis: Insights into Pathogenesis, Assessment, and Treatment

Key points

Overview

Epidemiology

Etiology and pathogenesis

Clinical manifestations

Laboratory studies

Diagnostic imaging

Monitoring disease activity

Bone biopsy

Diagnostic criteria

Treatment

Outcome and prognosis

Summary

Clinics care points

Unique Aspects of Pediatric Sjögren Disease

Key points

Introduction

Epidemiology

History, controversy, and terminology

Pathophysiology

Clinical features

Laboratory and diagnostic testing

Evolution of disease features over time

Differential diagnosis

Diagnosis and classification

Treatment

Outcomes

Summary

Disclosure

Juvenile Fibromyalgia

Key points

Introduction

Prevalence and clinical features of juvenile fibromyalgia

Etiology and pathogenesis

Prognosis for juvenile fibromyalgia

Evaluation of juvenile fibromyalgia in a rheumatology clinic

Diagnostic criteria for juvenile fibromyalgia

Treatment of juvenile fibromyalgia

Future research

Summary

Clinics care points

Juvenile Localized Scleroderma: Updates and Differences from Adult-Onset Disease

Key points

Introduction

Epidemiology

Pathogenesis

Patient evaluation overview: manifestations

Disease monitoring

Treatment

Summary

Clinics care points

Updates in Systemic Sclerosis Treatment and Applicability to Pediatric Scleroderma

Key points

Introduction

Medical treatment options and adjunct care

Organ system management

Vasculopathy

Summary of juvenile-onset systemic sclerosis treatment

Clinics care points

Disclosure

Recent Advances in Pediatric Vasculitis

Key points

Introduction

Large vessel vasculitis: Takayasu Arteritis

Medium vessel vasculitis

Small vessel vasculitis

Summary

Clinics care points

Disclosure

COVID-19 in Pediatrics

Key points

Coronavirus disease 2019 in children and adolescents

Multisystem Inflammatory Syndrome in Children

Future directions

Summary and Discussion

Clinics care points

Disclosure