Oxford Textbook of Rheumatoid Arthritis

This brand new textbook of rheumatoid arthritis (RA) is an important addition to the Oxford Textbooks in Rheumatology series, and provides a comprehensive overview of both the scientific and clinical aspects of the disease. Divided into eight sections - from the history, diagnosis, and epidemiology of the disease, through the pathogenesis, clinical presentation, and assessment to treatments and management strategies, both drug- and non-drug based - each chapter is written by leading clinicians and scientists in the field to deliver a contemporary view of RA.

During the past two decades there have been revolutionary changes in the understanding and management of rheumatoid arthritis, in particular the development of biological treatments. This has had wide-ranging effects on almost all aspects of treatment, from effectiveness and intensity to the nature and the cost. Providing a comprehensive account of the modern ideas about the disease, the Oxford Textbook of Rheumatoid Arthritis is a key new addition to the literature, with each chapter providing a detailed background, key recent advances, and areas of doubt and future developments.

Featuring over 170 photographs, radiological images, and clinical charts to aid both diagnosis and illustrate the rationale behind key scientific studies, this new title will prove an indispensable resource for specialist rheumatologists, trainees in rheumatology, and other members of the multi-disciplinary team.

Section 1 History, diagnosis, and epidemiology

1. The history of rheumatoid arthritis

2. Diagnosis

3. The descriptive epidemiology of rheumatoid arthritis

4. Modifiable and other risk factors for rheumatoid arthritis: A basis for prevention and better therapy

Section 2 Pathogenesis

5. Genetics and epigenetics of rheumatoid arthritis

6. Dysregulation of synovial fibroblasts in rheumatoid arthritis

7. Autoantibodies in rheumatoid arthritis

8. Dendritic cells and T cells in rheumatoid arthritis

9. Mechanisms of bone and cartilage destruction

10. Cytokines and other mediators

Section 3 Clinical presentation

11. Clinical features of rheumatoid arthritis

12. Pre-rheumatoid arthritis

13. Non-articular manifestations of rheumatoid arthritis

14. Comorbidity in rheumatoid arthritis

Section 4 Disease assessment

15. Disease activity assessment in rheumatoid arthritis

16. Synovial biopsies

17. Radiography in rheumatoid arthritis

18. Ultrasound in rheumatoid arthritis

19. Magnetic resonance imaging in rheumatoid arthritis

Section 5 Impact on life

20. Patient physical function in rheumatoid arthritis

21. Fatigue

22. Health economics of rheumatoid arthritis

23. Rheumatoid arthritis and work

Section 6 Non-drug treatments

24. Physical activity and exercise

25. Foot health

26. Occupational therapy

27. Self-management: A patient’s perspective

Section 7 Drug treatments

28. Analgesics, opioids, and NSAIDs

29. Glucocorticoids

30. Conventional disease-modifying drugs

31. Tumour necrosis factor inhibitors

32. Interleukin-6 inhibitors

33. B-cell therapies

34. Biosimilars

35. Immunogenicity in response to biologic agents

36. The use of JAK inhibitors in the treatment of rheumatoid arthritis

37. Combination therapy in rheumatoid arthritis

38. Translation of new therapies: From bench to bedside

39. Adverse events in clinical studies in rheumatoid arthritis

Section 8 Management and outcomes

40. Prevention of rheumatoid arthritis

41. Treatment targets and remission

42. Clinical outcomes

43. Clinical recommendations

44. European biologics registers

45. Voluntary patient registries

Index