Molecular Nutrition and Diabetes
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Molecular Nutrition and Diabetes

630 Lei 578 Lei(TVA inclus)
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Cod produs/ISBN: 9780128015858

Disponibilitate: La comanda in aproximativ 4 saptamani

Editura: Elsevier

Limba: Engleza

Nr. pagini: 400

Coperta: Hardcover

Dimensiuni: 21.6 x 2.22 x 28 cm

An aparitie: 1 Dec. 2015

 

Features:


  • Offers updated information and a perspective on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of diabetes mellitus
  • Explores how nutritional factors are involved in the pathogenesis of both type1 and type2 diabetes and their complications
  • Investigates the molecular and genetic bases of diabetes and diabetic metabolism through the lens of a rapidly evolving field of molecular nutrition



Table Of Contents:


  • Series Preface
  • Dedication
  • Contributors
  • Preface
  • Acknowledgments
  • Section 1. General and Introductory Aspects
    • Chapter 1. Nutrition and Diabetes: General Aspects
      • 1. Introduction
      • 2. Historical Perspective
      • 3. Guidelines
      • 4. Evidence from Clinical Trials
      • 5. Further Research
      • 6. Conclusions
    • Chapter 2. Dietary Patterns and Insulin Resistance
      • 1. Introduction
      • 2. Carbohydrates
      • 3. Lipids
      • 4. Proteins
      • 5. Concluding Remarks
    • Chapter 3. ß-Cell Metabolism, Insulin Production and Secretion: Metabolic Failure Resulting in Diabetes
      • 1. Introduction to Pancreatic ß-Cell Metabolism and Metabolic Links to Insulin Secretion
      • 2. The Role of Glucose Metabolism, Fatty Acid Metabolism, and Amino Acid Metabolism in the Generation of Metabolic Stimulus–Secretion Coupling Factors
      • 3. Nutrient Regulation of ß-Cell Gene Expression
      • 4. Metabolic Failure in ß-Cell Dysfunction and Onset of Diabetes
      • 5. The Cross-Talk of Apoptosis with ROS and ER Stress in ß-Cell Dysfunction
      • 6. Concluding Remarks
    • Chapter 4. Diet–Gene Interactions in the Development of Diabetes
      • 1. Early History of the Disease and the Seesaw of the Dietary Therapies
      • 2. Nutritional Management of Diabetes in the Twenty-First Century
      • 3. Diabetes, a Complex Disease with a Significant Genetic Component
      • 4. The Role of Gene–Diet Interactions in Diabetes Risk
      • 5. Concluding Remarks
    • Chapter 5. Pathogenesis of Type 1 Diabetes: Role of Dietary Factors
      • 1. Dietary Factors Involved in Type 1 Diabetes Development
      • 2. T1D, Celiac Disease, and Gluten Intake
      • 3. Dietary Gluten
      • 4. Gluten Peptides Are Resistant to Intestinal Degradation
      • 5. Dietary Gluten Influences the Development of T1D
      • 6. The Immune Response to Gluten in T1D Patients
      • 7. The Effect of Gluten on T1D Depends on Dose, Context, and Timing
      • 8. Gluten Intake, T1D, and the Intestinal Microflora
      • 9. Intestinal Alterations in Animal Models of T1D and Human Patients
      • 10. The Number of Pancreas-Infiltrating Autoreactive T Cells Is Increased in the Intestinal Tissue
      • 11. Intake of Gluten Changes Specific Immune System Parameters
      • 12. Gluten Is Found in Blood and Could Affect the Pancreatic ß Cells
      • 13. Conclusion
  • Section 2. Molecular Biology of the Cell
    • Chapter 6. Oxidative Stress in Diabetes: Molecular Basis for Diet Supplementation
      • 1. Introduction
      • 2. Oxidative Stress and Oxidation Damage in Diabetes
      • 3. Oxidative Stress and Oxidation Damage in Diabetic Complications
      • 4. Antioxidants in Diabetes: Implications for Use of Bioactive Food Components
      • 5. Conclusions
    • Chapter 7. Impact of Type 2 Diabetes on Skeletal Muscle Mass and Quality
      • 1. Introduction
      • 2. Regulation of Protein Degradation in Skeletal Muscle
      • 3. Skeletal Muscle Mass in Insulin Resistance and T2D
      • 4. TP53INP2 and its Role in Autophagy
      • 5. TP53INP2 in Skeletal Muscle and T2D
      • 6. Skeletal Muscle Quality in Insulin Resistance and T2D
      • 7. Mitochondrial Dynamics, Mitophagy, and Insulin Resistance
      • 8. Concluding Remarks
    • Chapter 8. Mechanisms Whereby Whole Grain Cereals Modulate the Prevention of Type 2 Diabetes
      • 1. Introduction
      • 2. Whole Grains versus Refined Flour
      • 3. Meta-Analyses and Epidemiological Studies
      • 4. Intervention Studies
      • 5. Mechanisms of Action
      • 6. Conclusions
    • Chapter 9. Peroxisome Proliferator-Activated Receptors (PPARs) in Glucose Control
      • 1. PPAR: An Overview
      • 2. Molecular Mechanisms of PPAR Activation
      • 3. The Role of PPARs in the Control of Glucose Metabolism
      • 4. Dietary-Derived PPAR Ligands as Supplementary Strategies in Glucose Control
      • 5. Conclusions
    • Chapter 10. High-Fat Diets and ß-Cell Dysfunction: Molecular Aspects
      • 1. Introduction
      • 2. Biology of the ß Cell
      • 3. Compensatory Response of the ß Cell to High-Fat Diet-Induced Insulin Resistance
      • 4. High-Fat Diet and ß-cell Failure and Death
      • 5. Concluding Remarks
    • Chapter 11. Native Fruits, Anthocyanins in Nutraceuticals, and the Insulin Receptor/Insulin Receptor Substrate-1/Akt/Forkhead Box Protein Pathway
      • 1. Anthocyanins: General Characteristics
      • 2. Anthocyanin Sources in Foods of Plant Origin
      • 3. Health Effects of Anthocyanins
      • 4. Insulin Signaling Pathway
      • 5. Molecular Mechanisms of Insulin Resistance
      • 6. Insulin Sensitizing and Antidiabetic Properties of Anthocyanins
      • 7. Concluding Remarks
    • Chapter 12. Influence of Dietary Factors on Gut Microbiota: The Role on Insulin Resistance and Diabetes Mellitus
      • 1. Introduction
      • 2. Influence of Dietary Factors on Gut Microbiota
      • 3. Impact of Prebiotics, Probiotics, and Exercise on Gut Microbiota
      • 4. Gut Microbiota Interactions with Insulin Resistance and Diabetes
      • 5. Gut Microbiota and Type 1 Diabetes
      • 6. Future Perspectives
    • Chapter 13. Molecular Aspects of Glucose Regulation of Pancreatic ß Cells
      • 1. Introduction
      • 2. Intracellular Glucose Signaling
      • 3. Glucose as a Mitogenic Signal for ß Cells
      • 4. Glucose Signaling and ß-Cell Transcription
      • 5. Glucotoxicity
      • 6. Concluding Remarks
    • Chapter 14. Metals in Diabetes: Zinc Homeostasis in the Metabolic Syndrome and Diabetes
      • 1. Introduction
      • 2. Zn and Insulin
      • 3. A Potential Risk of Zn Deficiency for the Metabolic Syndrome and Diabetes
      • 4. Effect of Diabetes on Zn Homeostasis
      • 5. Prevention and/or Improvement of Metabolic Syndrome and Diabetes by Zn Supplementation as well as Possible Mechanisms
      • 6. Conclusions
      • 7. Potential Clinical Implication for the Management of Diabetic Patients
    • Chapter 15. Cocoa Flavonoids and Insulin Signaling
      • 1. Introduction
      • 2. Physiology of Insulin Action
      • 3. Pathophysiology of Insulin Action
      • 4. Dietary Flavonoids
      • 5. Cocoa Flavonoids
      • 6. Cocoa Flavonoids and Insulin Action
      • 7. Conclusions
      • List of Abbreviations
    • Chapter 16. Dietary Proanthocyanidin Modulation of Pancreatic ß Cells: Molecular Aspects
      • 1. Proanthocyanidins: A Brief Description
      • 2. Proanthocyanidins and Type 1 Diabetes
      • 3. Type 2 Diabetes
      • 4. Proanthocyanidin Effects in Glucose Homeostasis on Insulin Resistance and on T2D
      • 5. Proanthocyanidin Effects on Insulin Sensing Tissues
      • 6. Proanthocyanidin Effects on ß-Cell Functionality: Control of Insulin Production
      • 7. Proanthocyanidin Effects on the Incretin System
      • 8. Human Studies
      • 9. Conclusions
    • Chapter 17. Dietary Whey Protein and Type 2 Diabetes: Molecular Aspects
      • 1. Introduction
      • 2. Constituents of the WP
      • 3. Studies in Support of the Antihyperglycemic Effect of Whey
      • 4. What Do Exercise and Dietary Protein Have to Do with Hyperglycemia?
      • 5. Type, Amount, and Form of Taking the Protein
      • 6. Whey Proteins and the Incretins
      • 7. Whey Peptides, Stress, and the Heat-Shock Proteins
      • 8. Possible Strategies for a More Rational Use of Whey Peptides
      • 9. Conclusions
    • Chapter 18. Dietary Fatty Acids and C-Reactive Protein
      • 1. Introduction
      • 2. CRP and Diabetes
      • 3. Diet and CRP
      • 4. Dietary Fatty Acids and CRP
      • 5. Conclusions
    • Chapter 19. Alcoholic Beverage and Insulin Resistance–Mediated Degenerative Diseases of Liver and Brain: Cellular and Molecular Effects
      • 1. Overview
      • 2. Alcohol-Related Liver Disease
      • 3. Alcohol-Related Neurodegeneration
      • 4. Concluding Remarks
  • Section 3. Genetic Machinery and its Function
    • Chapter 20. Genetic Variants and Risk of Diabetes
      • 1. Introduction
      • 2. Genetic Variants for T2D
      • 3. Genetic Variants for Insulin Secretion and Action
      • 4. Growth Factor Receptor-Bound Protein 10
      • 5. Rare and Low-Frequency Variants
      • 6. Genetic Prediction of T2D
      • 7. Future Directions
    • Chapter 21. MicroRNA and Diabetes Mellitus
      • 1. Introduction
      • 2. miRNA Biogenesis
      • 3. miRNAs Acting in ß-Cell Development
      • 4. miRNAs Acting on Glucose-Stimulated Insulin Secretion
      • 5. Regulation of Insulin Transcription by miRNAs
      • 6. ß-Cell Mass in Obesity and Pregnancy
      • 7. ß-Cell Failure in T2D
      • 8. miRNAs in Skeletal Muscle, Adipose Tissue, and Liver
      • 9. miRNAs Regulated by Nutritional State and Specific Ingredients
      • 10. miRNAs as Circulating Biomarkers
      • 11. Conclusions and Perspectives
      • List of Abbreviations
    • Chapter 22. Diabetes Mellitus and Intestinal Niemann-Pick C1–Like 1 Gene Expression
      • 1. Cholesterol Homeostasis
      • 2. Intestinal Cholesterol Absorption
      • 3. Intestinal NPC1L1 Cholesterol Transporter
      • 4. Transcriptional Regulation of NPC1L1
      • 5. NPC1L1 and Diseases
      • 6. NPC1L1 and Diabetes
      • 7. Conclusion
    • Chapter 23. Dietary Long Chain Omega-3 Polyunsaturated Fatty Acids and Inflammatory Gene Expression in Type 2 Diabetes
      • 1. Introduction
      • 2. Inflammation in T2D
      • 3. Inflammatory Gene Expression in T2D
      • 4. Long Chain Omega-3 Polyunsaturated Fatty Acids on Inflammation and T2D
      • 5. n-3 Polyunsaturated Fatty Acids on Neuroinflammation in Diabetes
      • 6. Conclusion
    • Chapter 24. Polymorphism, Carbohydrates, Fat, and Type 2 Diabetes
      • 1. Introduction
      • 2. Effect of Dietary Carbohydrates and Fat on T2D
      • 3. Polymorphisms and T2D
      • 4. Interaction between Carbohydrates, Fat, and Gene Polymorphisms
      • 5. Future Perspectives
    • Chapter 25. Genetic Basis Linking Variants for Diabetes and Obesity with Breast Cancer
      • 1. Obesity and Breast Cancer
      • 2. Insulin Resistance and Breast Cancer
      • 3. Adiponectin and Adiponectin Receptor 1 Genes
      • 4. Leptin and Leptin Receptor Genes
      • 5. Fat Mass and Obesity Associated Gene
      • 6. Obesity, Breast Cancer, and Methylation
      • 7. Nutrigenomics Perspective to Reduce Obesity-Mediated Breast Cancer Risk
      • 8. Conclusions
    • Chapter 26. Vitamin D Status, Genetics, and Diabetes Risk
      • 1. Vitamin D Metabolism and Epidemiology
      • 2. Vitamin D Deficiency and Diabetes Risk
      • 3. Genetic Basis of Vitamin D Deficiency
      • 4. Conclusions and Future Directions
    • Chapter 27. NRF2-Mediated Gene Regulation and Glucose Homeostasis
      • 1. Introduction
      • 2. Detoxification Processes in Cells
      • 3. Antioxidative Stress Response Systems in Cells
      • 4. Anti-inflammatory Function of NRF2
      • 5. Molecular Basis of the KEAP1-NRF2 System Function
      • 6. Pancreatic ß Cells and Oxidative and Nitrosative Stresses
      • 7. Roles of NRF2 on Antioxidative Response in Pancreatic ß Cells
      • 8. NRF2 Regulation of Inflammation and Other Cellular Responses in Pancreatic ß Cells
      • 9. Glucose Homeostasis in Insulin-Sensitive Tissues
      • 10. Nutrition and NRF2 Inducing Phytochemicals
      • 11. Conclusion
    • Chapter 28. Hepatic Mitochondrial Fatty Acid Oxidation and Type 2 Diabetes
      • 1. Introduction
      • 2. Lipogenesis as a Target to Reduce Liver Triacylglycerol Content
      • 3. Stimulation of the Peroxisome Proliferator-activated Receptor-a
      • 4. Peroxisome Proliferator-Activated Receptor-? Coactivator-1 as Target to Stimulate Hepatic Long-Chain Fatty Acid Oxidation
      • 5. Targeting Liver Mitochondrial Fatty Acid Oxidation to Improve Hepatic Insulin Sensitivity
      • 6. General Conclusion
    • Chapter 29. Current Knowledge on the Role of Wnt Signaling Pathway in Glucose Homeostasis
      • 1. Introduction of the Wnt Signaling Pathway
      • 2. Recognition of Wnt Signaling Pathway Components as Diabetes Risk Genes
      • 3. TCF7L2 as a Diabetic Risk Gene and Its Role in Glucose Homeostasis
      • 4. Summary and Perspectives
  • Index
   

 


An aparitie 1 Dec. 2015
Autor Didac Mauricio
Dimensiuni 21.6 x 2.22 x 28 cm
Editura Elsevier
Format Hardcover
ISBN 9780128015858
Limba Engleza
Nr pag 400

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