Diabetes: Epidemiology, Pathophysiology and Clinical Management

Description:

Diabetes: Epidemiology, Pathophysiology and Clinical Management aims to be the one-stop diabetes book for researchers, scientists and clinicians. It details the epidemiology, causes, molecular mechanisms, molecular markers, available drugs, experimental drugs, treatment modalities, and dietary and lifestyle approaches related to diabetes. It focuses on various molecular aspects of diabetes, and its related co-morbidities. Apart from the drug-based treatment approach based on international guidelines, this book also describes various surgical treatments available for cases of uncontrolled symptomatic diabetes. It also lays emphasis on the future possibilities of different approaches for diabetes management. Key Features Includes treatment guidelines and approaches to diabetes provided by major global diabetes associations Provides a thorough and comprehensive assimilation of detailed information and updates in the field of diabetes, helpful for researchers, scientists and clinicians Contains a chapter on anti-diabetic drugs, that covers both the commercially approved drugs as well as those that are in various phases of experimental, pre-clinical, and clinical trials

Table of Contents:

Chapter 1 Diabetes Epidemiology – 1980 and Beyond

Face-to-Face with the Global Diabetes Epidemiology

References

Chapter 2 Diabetes and Inflammation

Introduction

General Mechanism of Inflammation-Induced Insulin Resistance

Macrophage Activation and Insulin Resistance in Obesity

Role of Pro-Inflammatory Cytokines in Diabetes

Tumour Necrosis Factor – α

Interleukins

C – Reactive Protein (CRP)

Toll-Like Receptors

Conclusions

References

Chapter 3 Insulin Resistance and Glucose Regulation

Introduction to Insulin Resistance

Obesity as a Cause of Insulin Resistance

Free Fatty Acids

Adiponectin

TNF-α

Resistin and Interleukin-6

Leptin

Fibroblast Growth Factor 21

Dietary Effect on Insulin Resistance

Fatty Acid Mediated Insulin Resistance

Fructose-Induced Insulin Resistance

Conclusions

References

Chapter 4 Diabetes : A Leading Contributor to Other Disease Complications

Introduction

Pathophysiology of T2DM

Diabetes-Related Complications

Diabetic Retinopathy

Cardiovascular Disorders

Diabetic Nephropathy

Diabetic Neuropathy

Pulmonary Dysfunctions

Hepatic Dysfunction

Other Complications

Periodontitis

Genito-Urinary Infections

Tuberculosis

Gastroparesis

Conclusions

References

Chapter 5 Biomarkers of Diabetes

Biomarkers

Biomarkers for T1DM

Biomarkers for T2DM

Glycated Haemoglobin (HbA1c)

1, 5-Anhydroglucitol (1,5-AG)

Uric Acid

Chromogranin A

Skin and Lens Autofluorescence

References

Chapter 6 Anti-Diabetic Drugs

Introduction

Parenteral Anti-Diabetic Drugs (Insulin)

Oral Anti-Diabetic Drugs

Drugs for Diabetes Insipidus

Drugs from the Labs: The Story of Possibilities

GK Activators

FGF21 Mimetics

PTP-1B Inhibitors

RAGE Inhibitors

References

Chapter 7 Diagnosis and Treatment

Diagnosis of Diabetes

Pharmacological Treatment of Diabetes

Surgical Treatment of Diabetes

References

Chapter 8 Dietary and Lifestyle Management of Diabetes

Importance of Dietary and Lifestyle Management in Diabetes

Metabolic Effects of Exercise

Gut Microbiome and Diabetes: Old Companion with a New Angle

References

Chapter 9 Future Prospects and Recommendations

Index