Pubertal Suppression in Transgender Youth, 1e

Description:

Offering current guidelines on the relatively new practice of puberty suppression for gender-dysphoric adolescents, Pubertal Suppression in Transgender Youth provides a succinct, easy-to-digest overview of this timely topic. This concise, clinically-focused resource by Dr. Courtney Finlayson covers all relevant topics, from a brief history of medical care of transgender youth to emerging developments in the field.

 Table of Contents

·  Copyright

·  List of Contributors

·  Chapter 1. History of Care of Transgender Youth

·  Dedication

·  Chapter 2. Models of Care and Current Guidelines for Care of Transgender Individuals

·  Gender-Affirming Care

·  Multidisciplinary Care

·  Practice Guidelines

·  Mental Healthcare

·  Medical Care

·  Adjunctive Services

·  Barriers to Care

·  Summary

·  Chapter 3. Puberty

·  Physical Changes Associated With Puberty

·  Physiology of Puberty

·  Delayed Puberty or Absent Puberty (Sexual Infantilism)

·  Precocious Puberty (Sexual Precocity)

·  Chapter 4. GnRH Analogs (Mechanism, Past Studies, Drug Options, Use in Precocious Puberty, Use in Gender-Nonconforming Youth)

·  Historical Perspective

·  Physiology and Mechanism of Action

·  Use in Central Precocious Puberty

·  Outcomes in Central Precocious Puberty

·  Use in Gender-Nonconforming Youth

·  Options for Treatment

·  Outcomes in Gender-Nonconforming Youth

·  Challenges in Care

·  Conclusion

·  Chapter 5. Rationale for the Initiation, Use, and Monitoring of GnRHa in Gender Non-conforming Youth

·  Introduction

·  Rationale

·  Initiation

·  Monitoring

·  Conclusion

·  Chapter 6. Psychosocial Considerations in Pubertal Suppression Treatment

·  Introduction

·  Possible Effects of Gonadotropin-Releasing Hormone Analogues on Gender Identity and/or Sexuality Development

·  Unknown Neurocognitive Sequelae of Pubertal Suppression Treatment

·  Psychosocial Implications of Known Medical Side Effects of Gonadotropin-Releasing Hormone Analogue Treatment

·  Family Factors

·  Conclusion

·  Chapter 7. Medical Side Effects of GnRH Agonists

·  Bone Health

·  Brain

·  Fertility

·  Body Mass Index and Body Composition

·  Summary

·  Chapter 8. Surgical Side Effects of GnRHa

·  Introduction

·  Goals of Surgery

·  Timing of Surgery

·  Surgical Considerations for Individuals on GnRHa

·  Areas of Uncertainty

·  Conclusion

·  Chapter 9. Fertility Preservation: Considerations for Gender-Diverse Youth

·  Risk of Infertility due to Hormonal Therapies

·  Fertility Preservation Options in Birth-Assigned Males

·  Fertility Preservation Options in Birth-Assigned Females

·  Attitudes Toward FP and Other Psychological Considerations

·  Ethical Considerations

·  Financial Considerations

·  Future Directions

·  Conclusions

·  Chapter 10. Duration of Pubertal Suppression and Initiation of Gender-Affirming Hormone Treatment in Youth

·  Pubertal Suppression and Gender-Affirming Hormone Therapies

·  Relevant Time Points in Clinical Guidelines and Protocols

·  Unresolved Questions

·  Case Examples

·  Initiation of Gender-Affirming Hormones

·  Testosterone

·  Estrogen

·  Conclusions

·  Chapter 11. Ethical Considerations of GnRHa Treatment and Consent Process

·  Introduction

·  Pubertal Suppression

·  Benefits of Pubertal Suppression

·  Ethical Issues

·  Conclusion

·  Chapter 12. Emerging Developments in Pubertal Suppression for Gender Incongruent/Gender Dysphoric Youth

·  Triptorelin, a New Gonadotropin-Releasing Hormone Agonist

·  Prolonged Use of Histrelin acetate implant in Transgender Youth

·  Gonadotropin-Releasing Hormone Agonist Use in Nonbinary Youth

·  Gonadotropin-Releasing Hormone and Gonadotropin Antagonists

·  Kisspeptin and Neurokinin B Antagonists

·  Oxandrolone as an Alternative Gender-Affirming Masculinizing Hormone

·  Low-Dose Estrogen and Testosterone

·  Antiandrogens and Androgen Receptor Inhibitors

·  Antiandrogens

·  Conclusion