DESCRIERE:

Instrument util pentru luarea deciziilor terapeutice adecvate

Realizat intr-un format usor de utilizat, Manualul de Farmaco­terapie, Editia a zecea este un ghid util atat pentru profesionistii din farmacii, laboratoare, clinici, cat si pentru medicii, studentii si rezidentii din domeniu.

Pentru ca farmacistul sa devina un furnizor de servicii de asistența de sanatate, este necesara dez­voltarea competențelor, in cadrul pregatirii postuniversitare, atat prin rezidentiat si prin programe de educatie continua, cat si prin studiu individual. Accesul la surse de informare obiective este esential pentru o educatie de calitate, iar Manualul de Farmacoterapie poate fi un real sprijin in procesul de formare continua.

Ghidul ofera informatia esențiala pentru peste 140 de boli si afectiuni intalnite cel mai frecvent in practica clinica. Informatiile sunt prezentate sub forma de text, tabele, figuri sau algoritmi de tratament, totul pentru a facilita utilizarea si ințelegerea acestora.

 

Fiecare capitol este organizat intr‑o maniera similara, consecventa:

             • Definirea starii de boala

             • Prezentarea concisa a elementelor de fiziopatologie relevante

             • Tablou clinic

             • Diagnostic

             • Tratament

             • Evaluarea rezultatelor terapiei

              

Reactiile alergice si alte tulburari induse de medicamente, cum sunt cele hematologice, hepatice, pulmonare si renale sunt prezentate sub forma tabelara, in cinci anexe: Alergia la medicamente, Afectare hematologica indusă de medicamente, Afectare hepatica indusa de medicamente, Afectare pulmonara indusa de medicamente si Afectare renala indusa de medicamente. O alta anexa, de asemenea in format tabelar, include informatii privind managementul farmaco­terapiei la varstnici.

 

Traducerea si ingrijirea materialului a fost realizata de o echipa de 70 de profesionisti din domeniul farmaceutic, care include cadre didactice ale facultatilor de farmacie din tara (UMF Cluj, UMF Iasi, UMF Bucuresti), far­macisti specialisti in specialitatea farmacie clinica, medici si farmacisti rezidenti.

 

CUPRINS:

 

SECTIUNEA 1: AFECTIUNI ALE OASELOR SI ALE ARTICULATIILOR

1. Guta si hiperuricemia

2. Artroza

3. Osteoporoza

4. Artrita reumatoida

 

SECTIUNEA 2: BOLI CARDIOVASCULARE

5. Sindroamele coronariene acute

6. Aritmiile

7. Stopul cardiac

8. Dislipidemiile

9. Insuficiența cardiaca

10. Hipertensiunea arteriala

11. Boala cardiaca ischemica

12. Socul

13. Accidentul vascular cerebral

14. Tromboembolismul venos

 

SECȚIUNEA 3: AFECTIUNI DERMATOLOGICE

15. Acneea vulgara

16. Reactii dermatologice ale medicamentelor si afectiuni cutanate frecvente

17. Psoriazisul

 

SECTIUNEA 4: BOLI ENDOCRINE

18. Afectiunile glandei suprarenale

19. Diabetul zaharat

20. Afectiunile glandei tiroide

 

SECTIUNEA 5: AFECTIUNI GASTROINTESTINALE

21. Ciroza si hipertensiunea portală

22. Constipatia

23. Diareea

24. Boala de reflux gastroesofagian

25. Hepatitele virale

26. Boala inflamatorie intestinala

27. Greata si varsaturile

28. Pancreatita

29. Ulcerul gastroduodenal

 

SECTIUNEA 6: AFECTIUNI GINECOLOGICE SI OBSTETRICALE

30. Contraceptia

31. Terapia hormonala in menopauza, perimenopauza si postmenopauza

32. Sarcina si alaptarea: consideratii terapeutice

 

SECTIUNEA 7: AFECTIUNI HEMATOLOGICE

33. Anemiile

34. Siclemia

 

SECTIUNEA 8: BOLI INFECTIOASE

35. Alegerea regimului antimicrobian

36. Infectiile sistemului nervos central

37. Endocardita infectioasa

38. Infecțtile fungice invazive

39. Infectiile gastrointestinale

40. Infectia cu virusul imunodeficientei umane

41. Gripa

42. Infectiile intraabdominale

43. Infectiile tractului respirator inferior

44. Infectiile tractului respirator superior

45. Sepsisul si socul septic

46. Bolile cu transmitere sexuala

47. Infectiile cutanate si ale tesuturilor moi

48. Profilaxia antibiotica in chirurgie

49. Tuberculoza

50. Infectiile tractului urinar

51. Vaccinuri, toxoizi si alte imunobiologice

 

SECTIUNEA 9: TULBURARI NEUROLOGICE

52. Boala Alzheimer

53. Epilepsia

54. Cefaleea: migrena si cefaleea de tip tensional

55. Managementul durerii

56. Boala Parkinson

57. Statusul epileptic

 

SECȚIUNEA 10: TERAPIE NUTRITIONALA

58. Obezitatea

59. Evaluare nutriționala si suport

 

SECTIUNEA 11: AFECTIUNI ONCOLOGICE

60. Cancerul mamar

61. Cancerul colorectal

62. Cancerul pulmonar

63. Limfoamele

64. Cancerul de prostata

 

SECTIUNEA 12: AFECTIUNI OCULARE

65. Glaucomul

 

SECTIUNEA 13: TULBURARI PSIHICE

66. Tulburarea de anxietate generalizata, tulburarea de panica si tulburarea de stres posttraumatic

67. Tulburarea bipolara

68. Tulburarea depresiva majora

69. Schizofrenia

70. Tulburarile ciclului somn‑veghe

71. Tulburarile cauzate de consumul de substante

 

SECTIUNEA 14: AFECTIUNI RENALE

72. Dezechilibrele acido‑bazice

73. Insuficienta renala acuta

74. Boala renala cronica

75. Homeostazia electrolitica

 

SECTIUNEA 15: AFECTIUNI RESPIRATORII

76. Rinita alergica

77. Astmul bronsic

78. Bronhopneumopatia obstructiva cronica

 

SECTIUNEA 16: AFECTIUNI UROLOGICE

 

79. Hiperplazia benigna de prostata

80. Disfunctia erectila

81. Incontinenta urinara

 

ANEXE

ANEXA 1. Alergia la medicamente

ANEXA 2. Geriatrie

ANEXA 3. Afectare hematologica indusa de medicamente

ANEXA 4. Afectare hepatica indusa de medicamente

ANEXA 5. Afectare pulmonara indusa de medicamente

ANEXA 6. Afectare renala indusa de medicamente

 

Index

 

 

COLECTIVUL DE TRADUCERE SI CONSULTANTA STIINTIFICA

 

Coordonatorul editiei in limba romana

Adina Popa

Conferentiar dr., Disciplina de Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Iuliu Hatieganu”, Cluj‑Napoca

 

Colectivul de verificare si validare

Corina Bricis

Sef de lucrari dr., Disciplina de Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Iuliu Hatieganu”, Cluj‑Napoca

Diana Negru

Farmacist dr., MUSO SRL Romania

Cristina Pop

Sef de lucrari dr., Disciplina de Farmacologie, Fiziologie si Fiziopatologie, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Iuliu Hatieganu”, Cluj‑Napoca

Daniela Primejdie

Sef de lucrari dr., Disciplina de Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Iuliu Hatieganu”, Cluj‑Napoca

 

Colectivul de traducere

Capitolul 1 Cosmina Vircan, Farmacist specialist farmacie clinica, Farmacia Veroli, Cluj‑Napoca

Capitolul 2 Irina Cazacu, Asistent universitar dr., Disciplina de Farmacologie, Fiziologie si Fiziopatologie, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Iuliu Hațieganu”, Cluj‑Napoca

Capitolul 3 Denisa Baica, Farmacist specialist farmacie clinica, Terapia SA, Cluj‑Napoca

Capitolele 4 și 55 Veronica Bild, Profesor universitar dr., Disciplina de Farmacologie si Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Grigore T. Popa”, Iasi

Capitolele 5 și 69 Imola Borcsa, Farmacist, Farmacia Ambrosia, Targu Secuiesc

Capitolul 6 Oana Cristina Șeremet, Sef de lucrari dr., Disciplina de Farmacologie si Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Carol Davila”, Bucuresti

Alexandra Mihaela Tanase, Asistent universitar, Disciplina de Farmacologie si Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Carol Davila”, Bucuresti

Capitolul 7 Cristina Elena Zbarcea, Conferentiar dr., Disciplina de Farmacologie si Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie, „Carol Davila”, Bucuresti

Capitolul 8 Diana Negru, Farmacist dr., MUSO SRL, Romania

Capitolele 9, 74 și 78 Alina Grecu, Farmacist specialist farmacie clinica, Farmacia Astra, Brasov

Capitolul 10 Simona Negres, Profesor universitar dr., Disciplina de Farmacologie si Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Carol Davila”, Bucuresti

Cornel Chirița, Profesor universitar dr., Disciplina de Farmacologie si Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Carol Davila”, Bucuresti

Capitolul 11 Cristina Daniela Marineci, Asistent universitar, Disciplina de Farmacologie si Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Carol Davila”, Bucuresti

Capitolele 12 și 79 Oana Rad, Farmacist specialist farmacie clinica, Farmacia Veroli, Cluj‑Napoca

Capitolul 13 Anca Zanfirescu, Sef de lucrari dr., Disciplina de Farmacologie si Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Carol Davila”, Bucuresti

Capitolul 14 Bruno Velescu, Conferentiar universitar dr., Disciplina de Farmacologie si Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Carol Davila”, Bucuresti

Emil Ștefanescu, Sef de lucrari dr., Disciplina de Farmacologie si Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Carol Davila”, Bucuresti

Capitolele 15, 16 și 17 Mirela Moldovan, Conferentiar universitar, Disciplina de Dermatofarmacie si Cosmetologie, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Iuliu Hațieganu”, Cluj‑Napoca

Capitolul 18 Adriana Vidican, Farmacist specialist farmacie clinica, Spitalul Clinic Municipal „Dr. G. Curteanu”, Oradea

Capitolul 19 Anamaria Cristina, Asistent universitar, Disciplina de Farmacologie, Fiziologie si Fiziopatologie, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Iuliu Hațieganu”, Cluj‑Napoca

Capitolul 20 Ana Varadi, Farmacist, Farmacia Yucca Bodesti, Neamt

Capitolul 21 Andreea Pricopie, Farmacist specialist farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Iuliu Hațieganu”, Cluj‑Napoca

Capitolele 22 și 26 Alexandra Cristina Epure, Farmacist specialist farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Iuliu Hațieganu”, Cluj‑Napoca

Capitolele 23, 27 și Anexele 1, 5, 6 Ligia Hui, Farmacist specialist farmacie clinica, Spitalul Clinic Municipal Cluj‑Napoca

Capitolul 24 Ingrid Telecan, Farmacist, ProductLife Group Romania

Capitolul 25 și Anexa 3 Adina Torje, GP clinical pharmacist, Lea Vale Medical Group Luton, Marea Britanie

Capitolele 28 și 38 Teodora Curean, Farmacist, ProductLife Group Romania

Capitolul 29 Laura Todea, Farmacist specialist farmacie clinica, Pharmafarm Cluj

Capitolele 30, 31 și 80 Cristina Pop, Sef de lucrari dr., Disciplina de Farmacologie, Fiziologie si Fiziopatologie, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Iuliu Hatieganu”, Cluj‑Napoca

Capitolul 32 Corina Briciu, Sef de lucrari dr., Disciplina de Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Iuliu Hațieganu”, Cluj‑Napoca

Capitolul 33 Adela Cozlac, Farmacist specialist farmacie clinica, Farmacia Ducfarm, Cluj‑Napoca

Capitolele 34 și 50 Liana Moise, Farmacist, Richter Gedeon Romania

Capitolul 35 și Anexa 2 Daniela Primejdie, Sef de lucrari dr., Disciplina de Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Iuliu Hatieganu”, Cluj‑Napoca

Capitolele 36 și 47 Amalia Cosma, Farmacist specialist farmacie clinică, Clinical data coordinator Medpace, Leuven, Belgia

Capitolul 37 Gabriel Marc, Asistent universitar, Disciplina de Chimie farmaceutica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Iuliu Hațieganu”, Cluj‑Napoca

Capitolul 39 Laura Aldea-David, Farmacist specialist farmacie clinica, Sciformix a Covance Company, Romania

Capitolele 40 și 49 Roxana Dobrota, Farmacist specialist farmacie clinica, Farmacia Elmafarm, Cluj‑Napoca

Capitolul 41 Ioana Docea, Farmacist specialist farmacie clinica, Spitalul de Pneumoftiziologie, Aiud

Capitolul 42 Andrada Mirișan, Farmacist specialist farmacie clinica, Spitalul Judeţean de Urgenţa „Dr. Constantin Opris”, Baia Mare

Capitolul 43 Denisa Grozav, Farmacist specialist farmacie clinica, Farmacia Elmafarm, Cluj‑Napoca

Capitolul 44 Monica Ciornei, Farmacist rezident farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Iuliu Hațieganu”, Cluj‑Napoca

Capitolele 45 și 73 Iulia Anghel, Farmacist specialist farmacie clinica, Farmacia Elmafarm, Cluj‑Napoca

Capitolul 46 Sándor Szabó, Farmacist specialist farmacie clinica, Training manager, Farmaciile Ropharma

Capitolul 48 Iulia Popica, Farmacist specialist farmacie clinica, Farmacia Biofarm Șelimbar, Sibiu

Capitolul 51 Codruta Heghes, Sef de lucrari dr., Disciplina de Analiza Medicamentului, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Iuliu Hațieganu”, Cluj‑Napoca

Capitolele 52 și 56 Florentina Ban, Farmacist specialist farmacie clinica

Capitolul 53 Mirela Voicu, Sef de lucrari dr., Disciplina de Farmacologie si Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Victor Babes”, Timisoara

Cristiana Mabda, Asistent universitar, Disciplina de Farmacologie si Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Victor Babes”, Timisoara

Capitolul 54 și Anexa 4 Oana Bodea, Farmacist specialist farmacie clinica, ELC Group, Cluj‑Napoca

Capitolul 57 Maria Suciu, Sef de lucrari dr., Disciplina de Farmacologie si Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Victor Babes”, Timişoara

Valentina Buda, Asistent universitar, Disciplina de Farmacologie si Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicină si Farmacie „Victor Babes”, Timişoara

Capitolul 58 Eugenia Moldovan, Farmacist specialist farmacie clinica, Löwen Apotheke Esens, Germania

Capitolul 59 Dalma Badar-Fülöp, Farmacist specialist farmacie clinica, Farmacia Ducfarm, Cluj‑Napoca

Capitolul 60 Laura Budau, Farmacist, Centrul de Radioterapie Amethyst, Cluj‑Napoca

Capitolul 61 Alexandra Zahan, Farmacist specialist farmacie clinica, Centrul Medical Cardiomed, Cluj‑Napoca

Capitolul 62 Mariana Sipos, Farmacist specialist farmacie clinica, ProductLife Group România

Capitolul 63 Andreea Vieru, Farmacist specialist farmacie clinica, Farmacia Napofarm, Cluj‑Napoca

Capitolul 64 Sinziana Cetean, Asistent universitar dr., Disciplina de Chimie generala si anorganica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Iuliu Hațieganu”, Cluj‑Napoca

Capitolul 65 Oana Ghinea, Farmacist specialist farmacie clinica, Farmacia Richter Gedeon, Campia Turzii

Capitolele 66, 70 și 71 Maria Bonea, Asistent universitar, Disciplina de Psihiatrie si Psihiatrie pediatrica, Facultatea de Medicina, Universitatea de Medicina si Farmacie „Iuliu Hațieganu”, Cluj‑Napoca

Capitolele 67 și 68 Ioana Nonn, Farmacist, Farmacia Victor Babes, Cluj‑Napoca

Capitolul 72 Cristiana Arcălean, Farmacist specialist farmacie clinica, Spitalul Regina Maria, Cluj‑Napoca

Capitolele 75 și 81 Aura Blendea, Farmacist specialist farmacie clinica, Spitalul Clinic Județean de Urgenta, Cluj‑Napoca

Capitolul 76 Maria Brudiu, Farmacist specialist farmacie clinica, Spitalul Judetean de Urgența. Alba Iulia

Capitolul 77 Carmen Cristescu, Profesor universitar dr., Disciplina de Farmacologie si Farmacie clinica, Facultatea de Farmacie, Universitatea de Medicina si Farmacie „Victor Babes”, Timisoara

 

 

 

 

 

 

Ce am făcut noi?

     Am renunțat la unele capitole (cum ar fi „alegerea metodei de evaluare”); am adăugat capitole noi (de pildă „adaptarea cordului la efortul fizic”, „cardio-oncologia”); am ameliorat unele fragmente prin schimbarea autorilor (de exemplu „tomografia computerizată” scrisă de prof. dr. Ioana Lupescu, „rezonanța magnetică nucleară” de dr. Răzvan Capșa), am îmbogățit unele capitole (de pildă „regurgitarea aortică” scrisă de dr. Roxana Enache, acesta fiind titlul doctoratului său, „evaluarea riscului perioperator în chirurgia non-cardiacă și cardiacă” scrisă de noul intervenționist dr. Lucian Predescu).

Ce am adus nou?

     Am îmbogățit unele capitole, schimbându-le aspectul: am înlocuit, de exemplu, prezentarea de caz Marfan cu altele noi, fistulele cutanate și coronariene, la „evaluarea clinică a bolilor cardiovasculare”; am ameliorat capitolele (adăugând, de pildă, „ecografia de stres” la „ecocardiografie”; am adus la zi capitolele vechi, adăugându-le noile clasificări (la „cardiomiopatii”) sau noile indicații ale ghidurilor ESC (la capitolul „tromboembolismul pulmonar”); am schimbat aproape totul – în mod special prezentările de caz (la hipertensiunea pulmonară, bolile cardiace congenitale, pericardite).

Ce frapează acum?

     Aerul nou al cărții; plăcerea de a scrie oriunde a autorilor (capitolul de „prevenție” s-a scris în străinătate) și minuțiozitatea extremă a descrierilor (vezi insuficiența cardiacă) și expunerea excepționalei experiențe a medicilor (vezi „afectarea cardiacă în alte condiții patologice”).

     Astfel, putem spune că am preluat de la maeștrii noștri – prof. dr. C. C. Iliescu, prof. dr. Costin Carp, prof. dr. Eduard Apetrei – tot ceea ce au realizat; am „cules” de la scriitorii care au publicat în Editura Academiei Române claritatea stilului și am încercat să realizăm o carte foarte bună.

Ce spun autorii?

• O experiență nouă, o bucurie de a transmite ceea ce am învățat noilor generații alegând cu parcimonie ceea ce este de scris pe hârtie. (Prof. dr. Bogdan Alexandru Popescu)

• Am scris cu deosebită conștiinciozitate tot ce mi s-a părut interesant, încercând să „prind” publicul în nesfârșitele contradicții ale insuficienței cardiace și bolilor cardiace congenitale. (Prof. dr. Ioan Mircea Coman)

• Mi-am ales cu grijă temele pentru a ilustra cât mai convingător ce este nou printre factorii de risc, insuficiența cardiacă, ischemia mezenterică. Mi-am ridicat sus ștacheta și am încercat s-o depășesc. (Conf. dr. Ruxandra Jurcuț)

• Am încercat să ies din tipare, să fac atrăgătoare prezentările ECG și de HTA prin exemple deosebite și să adaug un nou „farmec” tromboembolismului pulmonar... (Dr. Carmen Beladan)

• Am scris cu atenție, reluând nu odată textul, încercând să fac cât mai clare valvulopatiile, cu nenumăratele lor nuanțe. (Dr. Andreea Călin)

• O experiență cu adevărat nouă. Am încercat împreună cu colegii mei de echipă și chirurgul șef al clinicii de chirurgie să descriu în amănunt bolile aortei și moartea subită și resuscitarea cardiacă cu toate datele sale noi. (Conf. dr. Ovidiu Chioncel)

• Mi-am dorit să limpezesc, să aduc la zi tot ceea ce se știe acum despre angina stabilă, inclusiv despre noile anticoagulante, și să ilustrez cât mai atrăgător tot ceea ce este nou. (Dr. Adrian Mereuță)

• Nu este numai ce s-a scris (pot zice că am muncit din greu la sindroamele coronariene acute cu supradenivelare de ST), ci și modul în care s-a lucrat, nesfârșita grijă pentru fiecare amănunt, pentru fiecare cuvânt. (Dr. Cosmin Călin)

Păreri ale cititorilor

   • Printr-un efort colectiv deosebit, gestionat cu deplină competență de editor, a rezultat o lucrare remarcabilă, care va servi ca o „carte de bază” pentru generațiile viitoare de cardiologi. (Prof. dr. Tiberiu Nanea)

 Usor de citit, cu un numar impresionant de desene anatomice si relevanta din punct de vedere clinic, Anatomia lui Gray pentru studenti, editia a patra, reprezinta manualul viitorilor medici in ceea ce priveste informatiile esentiale din anatomia umana. Acest volum complet revizuit se concentreaza pe cunostințele de baza pe care studentii trebuie sa le detina si se distinge printr-un format usor accesibil care faciliteaza parcurgerea eficienta a materialului. O echipa de autori si consilieri experti la nivel mondial isi impartasesc vasta experienta de predare si practica clinica, evidentiata si de cele peste 1 000 de ilustratii originale prezente pe parcursul cartii. 

• Ajuta studentii sa inteleaga aplicatiile practice ale conceptelor anatomice prin parcurgerea unica a anatomiei regionale, a imaginilor corelative de diagnostic si a studiilor clinice de caz. 
• Ofera conținut clinic complet revizuit si actualizat – incluzand numeroase noi casete de tip Noțiuni clinice plus noi cazuri medicale, ilustratii si informatii corelate pe parcursul intregului volum. 
• Permite cititorilor sa afle rapid conceptele de baza din fiecare capitol, cu ajutorul Descrierii generale. 
• Contine noi desene schematice pentru structurile si subiectele-cheie din fiecare capitol, oferind astfel o abordare simplificată, ideala pentru o ințelegere rapida și o reproducere ușoara a ilustratiilor de anatomie.
• Prezinta anatomia umana in mod logic in funcțte de regiunea corpului, acoperind fiecare dintre sistemele principale ale corpului pentru a facilita invatarea (sistemele cardiovascular, respirator, gastrointestinal, urogenital, limfatic si nervos).
Editia a patra a Anatomiei lui Gray pentru studenti este o carte moderna care poate fi inclusa fara ezitare in orice bibliografie. Conceputa pentru studentii din diferite arii medicale (medicina generala, dentara, dar si alte specialitati), lucrarea se dovedeste folositoare acestora in sistemul tradițional de invațamant, dar poate reprezenta si o completare adusa cursurilor si lucrarilor practice. Fiecare capitol poate fi tratat independent, ordinea in care acestea se studiaza neafectând calitatea actului educațional. Volumul se distinge printr-o buna traducere, care gaseste linia comuna intre limbajul anatomic american si cel romanesc.

 

Description:

Edited by Adam Feather, MBBS, FRCP, FAcadMEd; David Randall, MA, MRCP; and Mona Waterhouse, MA, MRCP

Contributors comprise consultants at the top of their fields, paired with younger doctors closer to the exam experience, to ensure authority and relevance.

Enhanced e-book accompanies the print book, for ease of transportation and use on the move.

International Advisory Board, led by Professor Janaka de Silva and Professor Senaka Rajapakse, providing guidance for global coverage from across the world.

Contributions to the e-book by members of the International Advisory Board to amplify areas of clinical importance in their parts of the world.

 

 

Table of Contents:

 

1. Diagnosis: The art of being a doctor

Core Skills and Knowledge

Diagnosis in the Clinical Consultation

The medical consultation

Clinical diagnostic reasoning

Communicating a diagnosis

Diagnosis, artificial intelligence and the future of medicine

2. Human genetics

Core Skills and Knowledge

Clinical skills for genetic medicine

Introduction

Clinical genetics

The cellular basis of genetics

Genetic disorders

Techniques for studying the genetic code

Genomic medicine

The genetic basis of cancer

3. Immunity

Core Skills and Knowledge

Introducing the tissues, cells and molecules of the immune system

Innate immune system

Adaptive immune system

Cell migration

HLA molecules and antigen presentation

The immune system in concert

Laboratory investigations of the immune system

Clinical immunodeficiency

Allergic disease (immediate hypersensitivity)

Autoimmune disease

Organ rejection in clinical transplantation

Immune-based therapies

4. Evidence-based practice

Core Skills and Knowledge

Introduction

Asking Answerable Questions

Searching for the Evidence

Appraising the Evidence

Applying the Evidence

Section 1: Asking Answerable Questions and Searching for the Evidence

Section 2: Critical Appraisal

Section 3: Interpreting Odds Ratios, Confidence Intervals and P-Values

Section 4: Multiple Choice Questions

5. Ethical practice and clinical communication

Core Skills and Knowledge

Ethics and the law

Communication in medicine

6. Malignant disease

Core Skills and Knowledge

Clinical skills for malignant disease

Introduction

The biology of cancer

Aetiology and epidemiology

Screening and investigations

Principles of cancer treatment

Acute oncology

Common solid tumour treatment

Lung cancer

Breast cancer

Upper gastrointestinal cancers

Lower gastrointestinal cancers

Hepatobiliary and pancreatic cancers

Urological cancers

Gynaecological cancers

Brain tumours

Head and neck cancer

Metastatic cancer of unknown primary

7. Palliative care and symptom control

Core Skills and Knowledge

Introduction and General Aspects

Symptom Control

Palliative Care in Non-Malignant Disease

Care of the Dying

8. Sepsis and the treatment of bacterial infection

Core Skills and Knowledge

clinical skills for infection and sepsis

Introduction

Pathophysiology

recognition of sepsis

Management of Sepsis

Antimicrobial Stewardship

Antibiotic Therapies

9. Water balance, fluids and electrolytes

Core skills and knowledge

Clinical skills for water balance, fluids and electrolytes

Water and Electrolytes

Disorders of sodium concentration

Disorders of potassium concentration

Disorders of magnesium concentration

Disorders of phosphate concentration

Acid–Base Disorders

10. Critical care medicine

Core Skills and Knowledge

Introduction

Clinical approach to the critically ill patient

Applied cardiorespiratory physiology

Disturbances of acid–base balance

Shock, sepsis and acute disturbances of haemodynamic function

Respiratory failure

Acute respiratory distress syndrome

Acute Kidney injury

Neurocritical care

Outcomes

11. Surgery

Core Skills and Knowledge

Clinical skills for surgery

Introduction

The pathophysiology of surgery

Management of the perioperative patient

The patient journey in surgery

Surgical Ethics, Consent and the Law

12. Prescribing, therapeutics and toxicology

Core Skills and Knowledge

Prescribing

Why do patients need drugs?

The choice of drug

The dose

Prescribing in special populations

Monitoring drug therapy

Adverse drug reactions

Drug interactions

Information sources

Poisoning

Clinical approach to the poisoned patient

Principles of management of poisoning

Specific poisons

Poisons in the natural world: additional online content

13. Global health

Core Skills and Knowledge

Introduction

Millennium and Sustainable Development Goals

Global Burden of Disease

Poverty

Water and Sanitation

Organizations and the global health agenda

Education

Maternal and Child Health

Mental health

Accidents and Trauma

Conflict and Catastrophe

Economics and Politics in Global Health

Social Determinants of Health

Human rights and the value of engagement in global health

14. Public health

Core Skills and Knowledge

Introduction

Key Concepts in Public Health

Pillars of Public Health

15. Geriatric medicine, frailty and multimorbidity

Core Skills and Knowledge

Introduction

Ageing

Investigations in Older Adults

Taking a History

Multimorbidity, Sarcopenia and Frailty

Comprehensive Geriatric Assessment

Advance Care Planning

The Most Common Issues in Older People

Ageing Well and Advantages of Ageing

16. Haematology

Core Skills and Knowledge

Clinical skills for haematology

Examination

Investigations

Introduction

The red cell

Anaemia: an introduction

Microcytic anaemia

Normocytic anaemia

Macrocytic anaemias

Anaemia due to marrow failure (aplastic anaemia)

Haemolytic anaemias: an introduction

Inherited haemolytic anaemia

Acquired haemolytic anaemia

Polycythaemia

The spleen

Blood transfusion

Blood groups

Procedure for blood transfusion in hospitals

Complications of blood transfusion

Strategies for the avoidance of unnecessary transfusion

Blood, blood components and blood products

The white cell

Haemostasis

Vascular disorders

Platelet disorders

Inherited coagulation disorders

Acquired coagulation disorders

17. Haematological oncology

Core Skills and Knowledge

Clinical skills for haematological oncology

Introduction

Leukaemias

Myelodysplasia

Clinical features

Investigations

Management

MDS/MPN overlap syndromes

Lymphomas

Myeloma and other plasma cell disorders

18. Rheumatology

Core Skills and Knowledge

Clinical skills for rheumatology

Approach to the patient

Anatomy and physiology of the normal joint

Investigation of rheumatic disease

Clinical conditions in rheumatology

Common regional musculoskeletal problems

Chronic pain syndromes

Analgesic and anti-inflammatory drugs for musculoskeletal problems

Disorders of collagen

Osteoarthritis

Inflammatory Arthritis

Rheumatoid arthritis

Spondyloarthritis

Infections of joints

Autoimmune rheumatic diseases

Systemic inflammatory vasculitis

Arthritis in children

Rheumatological problems seen in other diseases

Miscellaneous arthropathies

19. Bone disease

Core Skills and Knowledge

Clinical skills for bone disease

Anatomy and physiology of bone

Investigation of bone and calcium disorders

Osteoporosis

Osteonecrosis

Paget’s disease of bone

Rickets and osteomalacia

Bone infections

Neoplastic disease of bone

Scheuermann’s disease

20. Infectious disease

Core Skills and Knowledge

Core content

Clinical skills for infectious disease

Introduction

Clinical approach to the patient with a suspected infection

Epidemiology and prevention of infections

Principles and mechanisms of infection

Viral Infections

Virus infections of the skin and mucous membranes

Virus infections of the respiratory tract

Systemic viral infections

Virus infections of the nervous system

Virus infections of the gastrointestinal tract

Viral hepatitis

Viruses and malignant disease

Viral haemorrhagic fevers

Antiviral drugs

Transmissible Spongiform Encephalopathies (Prion Diseases)

Bacterial Infections

Bacterial infections of the skin and soft tissues

Bacterial infections of the respiratory tract

Bacterial infections of the gastrointestinal tract

Bacterial infections of the cardiovascular system

Bacterial infections of the nervous system

Bacterial bone and joint infections

Bacterial infections of the urinary tract

Systemic/multisystem bacterial infections

Bacterial infections seen in developing and tropical countries

Antibiotic therapies

Fungal Infections

Systemic fungal infections

Subcutaneous fungal infections

Superficial fungal infections

Antifungal drugs

Protozoal Infections

Blood and tissue protozoa

Gastrointestinal protozoa

Helminthic Infections

Nematodes

Trematodes

Cestodes

Arthropod Ectoparasites

21. Endocrinology

Core Skills and Knowledge

Clinical skills for endocrinology

Introduction

The pituitary gland and hypothalamus

Hypothalamo–Pituitary–adrenal axis

The thyroid axis

Hypothalamo–pituitary–gonadal axis

Growth and puberty

The Thirst Axis

Disorders of Calcium Metabolism

Hypoglycaemia in the non-diabetic patient

Other endocrine disorders

22. Dermatology

Core Skills and Knowledge

Clinical Skills for Dermatology

Introduction

Skin structure and function

Investigation of Skin Disease

Principles of Dermatological Therapy

Erythroderma and Loss of Skin Function (‘Skin Failure’)

Common rashes

Skin Infections

Human Immunodeficiency Virus and the Skin

Skin Signs of Systemic Disease

Photosensitivity

Blistering and Bullous Skin Disease

Skin Tumours

Disorders of Pigmentation

Nail Disorders

Hair Disorders

Birth Marks and Neonatal Rashes

Drug Eruptions

23. Diabetes mellitus

Core Skills and Knowledge

Clinical skills for diabetes mellitus

Introduction

Physiology of insulin structure, secretion and action

Classification of diabetes

Clinical Approach to the Patient With Diabetes

Prevention of Type 2 Diabetes

Management of diabetes

Diabetic metabolic emergencies

Complications of diabetes

Psychosocial Implications of Diabetes

Diabetes in special situations

Organization of diabetes care

24. Lipid and metabolic disorders

Core Skills and Knowledge

Introduction

History

Examination

Investigations

Disorders of lipid metabolism

Inherited metabolic diseases

25. Liaison psychiatry

Core Skills and Knowledge

Introduction

Clinical approach to the patient with a psychiatric disorder

Classification of psychiatric disorders

Aetiology of psychiatric disorders

Psychiatric aspects of physical diseases

Sick role and illness behaviour

Functional somatic syndromes

Somatoform disorders

Dissociative/conversion disorders

Sleep difficulties

Mood (affective) disorders

Suicide and self-harm

Anxiety disorders

Alcohol misuse and dependence

Drug misuse and dependence

Schizophrenia

Organic mental disorders

Eating disorders

Sexual disorders

Personality disorders

Involuntary Detention

Mental Capacity Act

26. Neurology

Core Skills and Knowledge

Clinical skills for neurology

Introduction

Clinical approach to the patient with neurological disease

Functional neuroanatomy

Cranial nerves

Motor control systems

Lower motor neurone lesions

Sensory pathways and pain

Bladder control and sexual dysfunction

Investigation of neurological disease

Unconsciousness and coma

Stroke

Intracranial haemorrhage

Headache, migraine and facial pain

Epilepsy and loss of consciousness

Movement disorders

Neuroinflammatory disorders

Nervous system infection

Hydrocephalus

Traumatic brain injury

Spinal cord disease

Neurodegenerative diseases

Congenital disorders

Neurogenetic disorders

Paraneoplastic syndromes

Peripheral nerve disease

Muscle diseases

27. Ear, nose and throat and eye disease

Core Skills and Knowledge

Introduction to ENT

Clinical approach to the patient with an ENT complaint

Disorders of the Ear

Clinical Approach to the Patient With a Disorder of the Ear

Common disorders of the ear

Disorders of the Nose

Clinical Approach to the Patient With a Disorder of the Nose

Common disorders of the nose

Disorders of the Throat

Clinical Approach to the Patient With a Disorder of the Throat

Common disorders of the throat

Disorders of the Eye

Applied Anatomy and Physiology

Clinical Approach to the Patient With a Disorder of the Eye

Common disorders of the eye

28. Respiratory disease

Core Skills and Knowledge

Clinical skills for respiratory medicine

Function of the respiratory system

Clinical Approach to the Patient with Respiratory Disease

Diseases of the Upper Respiratory Tract

Obstructive Respiratory Disease

Smoking

Respiratory Infection

Pleural Disease

Tumours of the Respiratory Tract

Bronchiectasis

Interstitial Lung Diseases

Lung and Heart–Lung Transplantation

Occupational Lung Disease

Miscellaneous Respiratory Disorders

Disorders of the Diaphragm

Mediastinal Lesions

29. Venous thromboembolic disease

Core Skills and Knowledge

Introduction

Pathogenesis of Thrombosis

Definitions

Epidemiology and Risk Factors

Clinical Features

Diagnosis

Management

Complications

Investigation of newly diagnosed venous thrombosis

Prevention

Anticoagulant agents

30. Cardiology

Core Skills and Knowledge

Clinical skills for cardiology

ECG interpretation

Anatomy, physiology and embryology of the heart

Clinical approach to the patient with heart disease

Therapeutic procedures

Cardiac arrhythmias

Bradycardias and heart block

Supraventricular tachycardias

Ventricular tachyarrhythmias

Heart failure

Coronary artery disease

Angina

Acute coronary syndromes

Valvular heart disease

Aortic valve

tricuspid valve

Pulmonary valve

Prosthetic valves

Infective endocarditis

Congenital heart disease

Marfan’s syndrome

Pulmonary heart disease

Myocardial and endocardial disease

Myocardial disease

Pericardial disease

Peripheral vascular disease

Peripheral venous disease

31. Hypertension

Core Skills and Knowledge

Introduction

Clinical Approach to the Patient with Hypertension

Measurement of blood pressure

Phenotypes of Hypertension

Causes of raised blood pressure

Thresholds and Targets In Hypertension

Hypertensive Target Organ Damage

Treatment

Managing blood pressure in hospital

32. Gastroenterology

Core Skills and Knowledge

Clinical Skills for Gastroenterology

INTRODUCTION

Anatomy and physiology of the gastrointestinal tract

Investigation of Gastrointestinal Disease

Functional Gastrointestinal Disorders

Mouth

Salivary Glands

Pharynx and Oesophagus

Stomach and Duodenum

Acute and Chronic Gastrointestinal Bleeding

Small Intestine

Inflammatory Bowel Disease

Colon and Rectum

The Acute Abdomen

Peritoneum

33. Nutrition

Core Skills and Knowledge

Introduction

Water and Electrolyte Balance

Dietary Requirements

Protein–Energy Malnutrition

Vitamins

Fat-soluble vitamins

Water-soluble vitamins

Dietary Antioxidants

Homocysteine, cardiovascular disease and B vitamins

Minerals

Nutrition and Ageing

Obesity

Nutritional Support

Food Allergy and Food Intolerance

Alcohol

34. Liver disease

Core Skills and Knowledge

Clinical skills for liver disease

Introduction

Anatomy of the liver and biliary system

Functions of the liver

Investigations in the patient with liver disease

Jaundice

Hepatitis

Acute hepatic failure

Autoimmune hepatitis

Drug-induced chronic hepatitis

Chronic hepatitis of unknown cause

Non-alcoholic fatty liver disease

Cirrhosis

Alcoholic liver disease

Budd–chiari syndrome

Hepatic sinusoidal obstruction syndrome

Fibropolycystic diseases

Liver abscess

Other infections of the liver

Liver disease in pregnancy

Liver tumours

Miscellaneous conditions of the liver

Drugs and the liver

35. Biliary tract and pancreatic disease

Core Skills and Knowledge

Introduction

Gall Bladder and Biliary System

Biliary system

Miscellaneous conditions of the biliary tract

Pancreas

Pancreatitis

Pancreatic cancer

Pancreatic neuroendocrine tumours

Clinical syndromes

Investigations

Management

36. Kidney and urinary tract disease

Core Skills and Knowledge

Clinical Skills for Nephrology

Examination

Introduction

Anatomy and Physiology of the Kidney and Urinary Tract

Investigation of Renal and Urinary Tract Disease

The Glomerulus and Glomerular Disease

Kidney Involvement in Other Diseases

Hypertension and the Kidney

Other Vascular Disorders of the Kidney

Renal Calculi and Nephrocalcinosis

Urinary Tract Obstruction

Drugs and the Kidney

Urinary Tract Infection

Tubulointerstitial Nephritis

Acute Kidney Injury

Chronic Kidney Disease

Cystic Renal Disease

Tumours of the Kidney and Genitourinary Tract

Diseases of the Prostate Gland

The Urinary Tract in the Elderly

37. Sexually transmitted infections and human immunodeficiency virus

Core Skills and Knowledge

Clinical skills for STI and HIV care

Sexually transmitted infections

Asymptomatic STI screening

Investigation of STIs

Management, prevention and control

Specific infections

Human immunodeficiency virus and acquired immunodeficiency syndrome

Clinical features of untreated hiv infection

Clinical approach to the patient with HIV

Management of HIV-positive patients

Specific conditions associated with HIV infection

Prevention and control of HIV infection

38. Obstetric medicine

Core Skills and Knowledge

Clinical Skills for Obstetric Medicine

Introduction

Hypertensive Disorders

Liver Disease

Cardiac Disease

Thromboembolic Disease

Respiratory Disease

Neurological Disease

Endocrine Disease

Renal Disease

Skin Disorders

RHEUMATIC DISEASE

Prescribing in Pregnancy

39. Women’s health

Core Skills and Knowledge

Clinical skills for women’s health

Introduction

The life course approach

Miscarriage

Heavy Menstrual Bleeding

Abortion/Termination of Pregnancy

Urinary Incontinence

Domestic abuse and violence

Gynaecological cancers

40. Men’s health

Core Skills and Knowledge

Clinical Skills For Men’s Health

Introduction

Specific Diseases of Men

Diseases of the prostate gland

Diseases of the Penis

Testicular and Spermatic Cord Disease

Lack of Libido and Erectile Dysfunction

Priapism

The Ageing Male

41. Environmental medicine

Core Skills and Knowledge

Air pollution

Heat Injury

Cold injury

High altitude

Diving

Drowning

Ionizing radiation

Electric shock

Lightning strike

Inhaled smoke

Index

Normal Values

 

 

Description:

Now combining general surgery and the specialties in one volume, this Sixth Edition of Essentials of General Surgery and Surgical Specialties focuses on the information all medical students need to know to pass the NBME surgery shelf or other surgery rotation examinations. This new edition of Lawrence’s popular text offers concise, high-yield content and a smaller format ideal for study on the go. Updated to reflect the latest advances in the field, it provides the authoritative, up-to-date content today’s busy medical students need for exam success.

Includes general surgery and surgical specialties all in one volume

Offers authoritative information by leading surgery educators

Provides five in-book practice questions per chapter, with additional questions online

Practice questions include answers and references to the area within the text where the topics are covered

Focuses on high-yield information for quick reference

 

 

Features:

Includes general surgery and surgical specialties all in one volume

Offers authoritative information by leading surgery educators

Provides five in-book practice questions per chapter, with additional questions online

Practice questions include answers and references to the area within the text where the topics are covered

Focuses on high-yield information for quick reference

Offers an array of online resources for both students and faculty

 

 

 

The only anatomy atlas illustrated by physicians, Atlas of Human Anatomy, 7th edition, brings you world-renowned, exquisitely clear views of the human body with a clinical perspective. In addition to the famous work of Dr. Frank Netter, you'll also find nearly 100 paintings by Dr. Carlos A. G. Machado, one of today's foremost medical illustrators. Together, these two uniquely talented physician-artists highlight the most clinically relevant views of the human body. In addition, more than 50 carefully selected radiologic images help bridge illustrated anatomy to living anatomy as seen in everyday practice.

·         Region-by-region coverage, including Muscle Table appendices at the end of each section.

·         Large, clear illustrations with comprehensive labels not only of major structures, but also of those with important relationships.

·         Tabular material in separate pages and additional supporting material as a part of the electronic companion so the printed page stays focused on the illustration.

Updates to the 7th Edition - based on requests from students and practitioners alike:

·         New Systems Overview section featuring brand-new, full-body views of surface anatomy, vessels, nerves, and lymphatics.

·         More than 25 new illustrations by Dr. Machado, including the clinically important fascial columns of the neck, deep veins of the leg, hip bursae, and vasculature of the prostate; and difficult-to-visualize areas like the infratemporal fossa.

·         New Clinical Tables at the end of each regional section that focus on structures with high clinical significance. These tables provide quick summaries, organized by body system, and indicate where to best view key structures in the illustrated plates.

·         More than 50 new radiologic images - some completely new views and others using newer imaging tools - have been included based on their ability to assist readers in grasping key elements of gross anatomy.

·         Updated terminology based on the international anatomic standard, Terminologia Anatomica, with common clinical eponyms included.

·         Student Consult access includes a pincode to unlock the complete enhanced eBook of the Atlas through Student Consult. Every plate in the Atlas-and over 100 Bonus Plates including illustrations from previous editions-are enhanced with an interactive label quiz option and supplemented with "Plate Pearls" that provide quick key points and supplemental tools for learning, reviewing, and assessing your knowledge of the major themes of each plate. Tools include 300 multiple choice questions, videos, 3D models, and links to related plates.

 


Product description

Review

Unsurpassed illustrations of human anatomy for medicine and healthcare

About the Author

Frank H. Netter was born in New York City in 1906. He studied art at the Art Students League and the National Academy of Design before entering medical school at New York University, where he received his Doctor of Medicine degree in 1931. During his student years, Dr. Netter's notebook sketches attracted the attention of the medical faculty and other physicians, allowing him to augment his income by illustrating articles and textbooks. He continued illustrating as a sideline after establishing a surgical practice in 1933, but he ultimately opted to give up his practice in favor of a full-time commitment to art. After service in the United States Army during World War II, Dr. Netter began his long collaboration with the CIBA Pharmaceutical Company (now Novartis Pharmaceuticals). This 45-year partnership resulted in the production of the extraordinary collection of medical art so familiar to physicians and other medical professionals worldwide. Icon Learning Systems acquired the Netter Collection in July 2000 and continued to update Dr. Netter's original paintings and to add newly commissioned paintings by artists trained in the style of Dr. Netter. In 2005, Elsevier Inc. purchased the Netter Collection and all publications from Icon Learning Systems. There are now over 50 publications featuring the art of Dr. Netter available through Elsevier Inc.

Dr. Netter's works are among the finest examples of the use of illustration in the teaching of medical concepts. The 13-book Netter Collection of Medical Illustrations, which includes the greater part of the more than 20,000 paintings created by Dr. Netter, became and remains one of the most famous medical works ever published. The Netter Atlas of Human Anatomy, first published in 1989, presents the anatomic paintings from the Netter Collection. Now translated into 16 languages, it is the anatomy atlas of choice among medical and health professions students the world over.

The Netter illustrations are appreciated not only for their aesthetic qualities, but, more importantly, for their intellectual content. As Dr. Netter wrote in 1949 "clarification of a subject is the aim and goal of illustration. No matter how beautifully painted, how delicately and subtly rendered a subject may be, it is of little value as a medical illustration if it does not serve to make clear some medical point.” Dr. Netter's planning, conception, point of view, and approach are what inform his paintings and what make them so intellectually valuable.

Frank H. Netter, MD, physician and artist, died in 1991.

Urgentele cardiovasculare continua sa detina primul loc ca incidenta, severitate si risc de deces. Frecvent, rapiditatea interventiei terapeutice este aceea care decide viata sau moartea bolnavilor. De aceea, se impune cunoasterea si aplicarea, cel putin intr-o prima etapa, a unor algoritmi simpli de diagnostic si tratament care sa ofere bolnavilor sansa de a supravietui. Este ceea ce incearca sa ofere Urgente cardiovasculare in camera de garda. Desigur, dupa aplicarea primelor masuri de diagnostic si tratament, medicul va avea timp sa consulte si sa recurga la toate manoperele si terapiile recomandate in ghiduri sau in tratate de specialitate.

Description:

 

MASTER MODERN MEDICINE! Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible. Essential for practice and education, the landmark 20th Edition features: Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care. State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals. All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine—Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine. Important and timely new chapters—such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more—offer the very latest, definitive perspectives on must-know topics in medical education and practice. Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes. End-of-chapter suggested readings reinforce the text material and provide a robust platform for further study and research.

 

Table of Contents:

PART 1 The Profession of Medicine

1 The Practice of Medicine

2 Promoting Good Health

3 Decision-Making in Clinical Medicine

4 Screening and Prevention of Disease

5 Health Care Systems in Developed Countries

6 The Safety and Quality of Health Care

7 Racial and Ethnic Disparities in Health Care

8 Ethical Issues in Clinical Medicine

9 Palliative and End-of-Life Care

PART 2 Cardinal Manifestations and Presentation of Diseases

SECTION 1 Pain

10 Pain: Pathophysiology and Management

11 Chest Discomfort

12 Abdominal Pain

13 Headache

14 Back and Neck Pain

SECTION 2 Alterations in Body Temperature

15 Fever

16 Fever and Rash

17 Fever of Unknown Origin

SECTION 3 Nervous System Dysfunction

18 Syncope

19 Dizziness and Vertigo

20 Fatigue

21 Neurologic Causes of Weakness and Paralysis

22 Numbness, Tingling, and Sensory Loss

23 Gait Disorders, Imbalance, and Falls

24 Confusion and Delirium

25 Dementia

26 Aphasia, Memory Loss, Hemispatial Neglect, Frontal Syndromes, and Other Cerebral Disorders

27 Sleep Disorders

SECTION 4 Disorders of Eyes, Ears, Nose, and Throat

28 Disorders of the Eye

29 Disorders of Smell and Taste

30 Disorders of Hearing

31 Sore Throat, Earache, and Upper Respiratory Symptoms

32 Oral Manifestations of Disease

SECTION 5 Alterations in Circulatory and Respiratory Functions

33 Dyspnea

34 Cough

35 Hemoptysis

36 Hypoxia and Cyanosis

37 Edema

38 Approach to the Patient with a Heart Murmur

39 Palpitations

SECTION 6 Alterations in Gastrointestinal Function

40 Dysphagia

41 Nausea, Vomiting, and Indigestion

42 Diarrhea and Constipation

43 Unintentional Weight Loss

44 Gastrointestinal Bleeding

45 Jaundice

46 Abdominal Swelling and Ascites

SECTION 7 Alterations in Renal and Urinary Tract Function

47 Dysuria, Bladder Pain, and the Interstitial Cystitis/Bladder Pain Syndrome

48 Azotemia and Urinary Abnormalities

49 Fluid and Electrolyte Disturbances

50 Hypercalcemia and Hypocalcemia

51 Acidosis and Alkalosis

SECTION 8 Alterations in the Skin

52 Approach to the Patient with a Skin Disorder

53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders

54 Skin Manifestations of Internal Disease

55 Immunologically Mediated Skin Diseases

56 Cutaneous Drug Reactions

57 Photosensitivity and Other Reactions to Light

SECTION 9 Hematologic Alterations

58 Interpreting Peripheral Blood Smears

59 Anemia and Polycythemia

60 Disorders of Granulocytes and Monocytes

61 Bleeding and Thrombosis

62 Enlargement of Lymph Nodes and Spleen

PART 3 Pharmacology

63 Principles of Clinical Pharmacology

64 Pharmacogenomics

PART 4 Oncology and Hematology

SECTION 1 Neoplastic Disorders

65 Approach to the Patient with Cancer

66 Prevention and Early Detection of Cancer

67 Cancer Genetics

68 Cancer Cell Biology

69 Principles of Cancer Treatment

70 Infections in Patients with Cancer

71 Oncologic Emergencies

72 Cancer of the Skin

73 Head and Neck Cancer

74 Neoplasms of the Lung

75 Breast Cancer

76 Upper Gastrointestinal Tract Cancers

77 Lower Gastrointestinal Cancers

78 Tumors of the Liver and Biliary Tree

79 Pancreatic Cancer

80 Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas

81 Renal Cell Carcinoma

82 Cancer of the Bladder and Urinary Tract

83 Benign and Malignant Diseases of the Prostate

84 Testicular Cancer

85 Gynecologic Malignancies

86 Primary and Metastatic Tumors of the Nervous System

87 Soft Tissue and Bone Sarcomas and Bone Metastases

88 Carcinoma of Unknown Primary

89 Paraneoplastic Syndromes: Endocrinologic/Hematologic

90 Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis

91 Late Consequences of Cancer and Its Treatment

SECTION 2 Hematopoietic Disorders

92 Hematopoietic Stem Cells

93 Iron Deficiency and Other Hypoproliferative Anemias

94 Disorders of Hemoglobin

95 Megaloblastic Anemias

96 Hemolytic Anemias

97 Anemia Due to Acute Blood Loss

98 Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia

99 Polycythemia Vera and Other Myeloproliferative Neoplasms

100 Acute Myeloid Leukemia

101 Chronic Myeloid Leukemia

102 Acute Lymphoid Leukemia

103 Chronic Lymphocytic Leukemia

104 Non-Hodgkin’s Lymphoma

105 Hodgkin’s Lymphoma

106 Less Common Hematologic Malignancies

107 Plasma Cell Disorders

108 Amyloidosis

109 Transfusion Biology and Therapy

110 Hematopoietic Cell Transplantation

SECTION 3 Disorders of Hemostasis

111 Disorders of Platelets and Vessel Wall

112 Coagulation Disorders

113 Arterial and Venous Thrombosis

114 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs

PART 5 Infectious Diseases

SECTION 1 Basic Considerations in Infectious Diseases

115 Approach to the Patient with an Infectious Disease

116 Molecular Mechanisms of Microbial Pathogenesis

117 Approach to the Acutely Ill Infected Febrile Patient

118 Immunization Principles and Vaccine Use

119 Health Recommendations for International Travel

120 Climate Change and Infectious Disease

SECTION 2 Clinical Syndromes: Community-Acquired Infections

121 Pneumonia

122 Lung Abscess

123 Infective Endocarditis

124 Infections of the Skin, Muscles, and Soft Tissues

125 Infectious Arthritis

126 Osteomyelitis

127 Intraabdominal Infections and Abscesses

128 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning

129 Clostridium difficile Infection, Including Pseudomembranous Colitis

130 Urinary Tract Infections, Pyelonephritis, and Prostatitis

131 Sexually Transmitted Infections: Overview and Clinical Approach

132 Encephalitis

133 Acute Meningitis

134 Chronic and Recurrent Meningitis

135 Brain Abscess and Empyema

136 Infectious Complications of Bites

SECTION 3 Clinical Syndromes: Health Care–Associated Infections

137 Infections Acquired in Health Care Facilities

138 Infections in Transplant Recipients

SECTION 4 Therapy for Bacterial Diseases

139 Treatment and Prophylaxis of Bacterial Infections

140 Bacterial Resistance to Antimicrobial Agents

SECTION 5 Diseases Caused by Gram-Positive Bacteria

141 Pneumococcal Infections

142 Staphylococcal Infections

143 Streptococcal Infections

144 Enterococcal Infections

145 Diphtheria and Other Corynebacterial Infections

146 Listeria monocytogenes Infections

147 Tetanus

148 Botulism

149 Gas Gangrene and Other Clostridial Infections

SECTION 6 Diseases Caused by Gram-Negative Bacteria

150 Meningococcal Infections

151 Gonococcal Infections

152 Haemophilus and Moraxella Infections

153 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria

154 Legionella Infections

155 Pertussis and Other Bordetella Infections

156 Diseases Caused by Gram-Negative Enteric Bacilli

157 Acinetobacter Infections

158 Helicobacter pylori Infections

159 Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species

160 Salmonellosis

161 Shigellosis

162 Infections Due to Campylobacter and Related Organisms

163 Cholera and Other Vibrioses

164 Brucellosis

165 Tularemia

166 Plague and Other Yersinia Infections

167 Bartonella Infections, Including Cat-Scratch Disease

168 Donovanosis

SECTION 7 Miscellaneous Bacterial Infections

169 Nocardiosis

170 Actinomycosis

171 Whipple’s Disease

172 Infections Due to Mixed Anaerobic Organisms

SECTION 8 Mycobacterial Diseases

173 Tuberculosis

174 Leprosy

175 Nontuberculous Mycobacterial Infections

176 Antimycobacterial Agents

SECTION 9 Spirochetal Diseases

177 Syphilis

178 Endemic Treponematoses

179 Leptospirosis

180 Relapsing Fever

181 Lyme Borreliosis

SECTION 10 Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae

182 Rickettsial Diseases

183 Infections Due to Mycoplasmas

184 Chlamydial Infections

SECTION 11 Viral Diseases: General Considerations

185 Medical Virology

186 Antiviral Chemotherapy, Excluding Antiretroviral Drugs

SECTION 12 Infections Due to DNA Viruses

187 Herpes Simplex Virus Infections

188 Varicella-Zoster Virus Infections

189 Epstein-Barr Virus Infections, Including Infectious Mononucleosis

190 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8

191 Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections

192 Parvovirus Infections

193 Human Papillomavirus Infections

SECTION 13 Infections Due to DNA and RNA Respiratory Viruses

194 Common Viral Respiratory Infections

195 Influenza

SECTION 14 Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses

196 The Human Retroviruses

197 Human Immunodeficiency Virus Disease: AIDS and Related Disorders

SECTION 15 Infections Due to RNA Viruses

198 Viral Gastroenteritis

199 Enterovirus, Parechovirus, and Reovirus Infections

200 Measles (Rubeola)

201 Rubella (German Measles)

202 Mumps

203 Rabies and Other Rhabdovirus Infections

204 Arthropod-Borne and Rodent-Borne Virus Infections

205 Ebolavirus and Marburgvirus Infections

SECTION 16 Fungal Infections

206 Diagnosis and Treatment of Fungal Infections

207 Histoplasmosis

208 Coccidioidomycosis

209 Blastomycosis

210 Cryptococcosis

211 Candidiasis

212 Aspergillosis

213 Mucormycosis

214 Superficial Mycoses and Less Common Systemic Mycoses

215 Pneumocystis Infections

SECTION 17 Protozoal and Helminthic Infections: General Considerations

216 Introduction to Parasitic Infections

217 Agents Used to Treat Parasitic Infections

SECTION 18 Protozoal Infections

218 Amebiasis and Infection with Free-Living Amebae

219 Malaria

220 Babesiosis

221 Leishmaniasis

222 Chagas Disease and African Trypanosomiasis

223 Toxoplasma Infections

224 Protozoal Intestinal Infections and Trichomoniasis

SECTION 19 Helminthic Infections

225 Introduction to Helminthic Infections

226 Trichinellosis and Other Tissue Nematode Infections

227 Intestinal Nematode Infections

228 Filarial and Related Infections

229 Schistosomiasis and Other Trematode Infections

230 Cestode Infections

PART 6 Disorders of the Cardiovascular System

SECTION 1 Introduction to Cardiovascular Disorders

231 Approach to the Patient with Possible Cardiovascular Disease

232 Basic Biology of the Cardiovascular System

233 Epidemiology of Cardiovascular Disease

SECTION 2 Diagnosis of Cardiovascular Disorders

234 Physical Examination of the Cardiovascular System

235 Electrocardiography

236 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging

237 Diagnostic Cardiac Catheterization and Coronary Angiography

SECTION 3 Disorders of Rhythm

238 Principles of Electrophysiology

239 The Bradyarrhythmias: Disorders of the Sinoatrial Node

240 The Bradyarrhythmias: Disorders of the Atrioventricular Node

241 Approach to Supraventricular Tachyarrhythmias

242 Physiologic and Nonphysiologic Sinus Tachycardia

243 Focal Atrial Tachycardia

244 Paroxysmal Supraventricular Tachycardias

245 Common Atrial Flutter, Macroreentrant, and Multifocal Atrial Tachycardias

246 Atrial Fibrillation

247 Approach to Ventricular Arrhythmias

248 Premature Ventricular Beats, Non-Sustained Ventricular Tachycardia, and Idioventricular Rhythm

249 Sustained Ventricular Tachycardia

250 Polymorphic Ventricular Tachycardia and Ventricular Fibrillation

251 Electrical Storm and Incessant VT

SECTION 4 Disorders of the Heart

252 Heart Failure: Pathophysiology and Diagnosis

253 Heart Failure: Management

254 Cardiomyopathy and Myocarditis

255 Cardiac Transplantation and Prolonged Assisted Circulation

256 Aortic Valve Disease

257 Aortic Regurgitation

258 Mitral Stenosis

259 Mitral Regurgitation

260 Mitral Valve Prolapse

261 Tricuspid Valve Disease

262 Pulmonic Valve Disease

263 Multiple and Mixed Valvular Heart Disease

264 Congenital Heart Disease in the Adult

265 Pericardial Disease

266 Atrial Myxoma and Other Cardiac Tumors

SECTION 5 Coronary and Peripheral Vascular Disease

267 Ischemic Heart Disease

268 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina)

269 ST-Segment Elevation Myocardial Infarction

270 Percutaneous Coronary Interventions and Other Interventional Procedures

271 Hypertensive Vascular Disease

272 Renovascular Disease

273 Deep Venous Thrombosis and Pulmonary Thromboembolism

274 Diseases of the Aorta

275 Arterial Diseases of the Extremities

276 Chronic Venous Disease and Lymphedema

277 Pulmonary Hypertension

PART 7 Disorders of the Respiratory System

SECTION 1 Diagnosis of Respiratory Disorders

278 Approach to the Patient with Disease of the Respiratory System

279 Disturbances of Respiratory Function

280 Diagnostic Procedures in Respiratory Disease

SECTION 2 Diseases of the Respiratory System

281 Asthma

282 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia

283 Occupational and Environmental Lung Disease

284 Bronchiectasis

285 Cystic Fibrosis

286 Chronic Obstructive Pulmonary Disease

287 Interstitial Lung Disease

288 Disorders of the Pleura

289 Disorders of the Mediastinum

290 Disorders of Ventilation

291 Sleep Apnea

292 Lung Transplantation

PART 8 Critical Care Medicine

SECTION 1 Respiratory Critical Care

293 Approach to the Patient with Critical Illness

294 Acute Respiratory Distress Syndrome

295 Mechanical Ventilatory Support

SECTION 2 Shock and Cardiac Arrest

296 Approach to the Patient with Shock

297 Sepsis and Septic Shock

298 Cardiogenic Shock and Pulmonary Edema

299 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death

SECTION 3 Neurologic Critical Care

300 Coma

301 Severe Acute Encephalopathies and Critical Care Weakness

302 Subarachnoid Hemorrhage

PART 9 Disorders of the Kidney and Urinary Tract

303 Cellular and Molecular Biology of the Kidney

304 Acute Kidney Injury

305 Chronic Kidney Disease

306 Dialysis in the Treatment of Renal Failure

307 Transplantation in the Treatment of Renal Failure

308 Glomerular Diseases

309 Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development

310 Tubulointerstitial Diseases of the Kidney

311 Vascular Injury to the Kidney

312 Nephrolithiasis

313 Urinary Tract Obstruction

PART 10 Disorders of the Gastrointestinal System

SECTION 1 Disorders of the Alimentary Tract

314 Approach to the Patient with Gastrointestinal Disease

315 Gastrointestinal Endoscopy

316 Diseases of the Esophagus

317 Peptic Ulcer Disease and Related Disorders

318 Disorders of Absorption

319 Inflammatory Bowel Disease

320 Irritable Bowel Syndrome

321 Diverticular Disease and Common Anorectal Disorders

322 Mesenteric Vascular Insufficiency

323 Acute Intestinal Obstruction

324 Acute Appendicitis and Peritonitis

SECTION 2 Nutrition

325 Nutrient Requirements and Dietary Assessment

326 Vitamin and Trace Mineral Deficiency and Excess

327 Malnutrition and Nutritional Assessment

328 Enteral and Parenteral Nutrition

SECTION 3 Liver and Biliary Tract Disease

329 Approach to the Patient with Liver Disease

330 Evaluation of Liver Function

331 The Hyperbilirubinemias

332 Acute Viral Hepatitis

333 Toxic and Drug-Induced Hepatitis

334 Chronic Hepatitis

335 Alcoholic Liver Disease

336 Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis

337 Cirrhosis and Its Complications

338 Liver Transplantation

339 Diseases of the Gallbladder and Bile Ducts

SECTION 4 Disorders of the Pancreas

340 Approach to the Patient with Pancreatic Disease

341 Acute and Chronic Pancreatitis

PART 11 Immune-Mediated, Inflammatory, and Rheumatologic Disorders

SECTION 1 The Immune System in Health and Disease

342 Introduction to the Immune System

343 The Major Histocompatibility Complex

344 Primary Immune Deficiency Diseases

SECTION 2 Disorders of Immune-Mediated Injury

345 Urticaria, Angioedema, and Allergic Rhinitis

346 Anaphylaxis

347 Mastocytosis

348 Autoimmunity and Autoimmune Diseases

349 Systemic Lupus Erythematosus

350 Antiphospholipid Syndrome

351 Rheumatoid Arthritis

352 Acute Rheumatic Fever

353 Systemic Sclerosis (Scleroderma) and Related Disorders

354 Sjögren’s Syndrome

355 The Spondyloarthritides

356 The Vasculitis Syndromes

357 Behçet’s Syndrome

358 Inflammatory Myopathies

359 Relapsing Polychondritis

360 Sarcoidosis

361 IgG4-Related Disease

362 Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases

SECTION 3 Disorders of the Joints and Adjacent Tissues

363 Approach to Articular and Musculoskeletal Disorders

364 Osteoarthritis

365 Gout and Other Crystal-Associated Arthropathies

366 Fibromyalgia

367 Arthritis Associated with Systemic Disease, and Other Arthritides

368 Periarticular Disorders of the Extremities

PART 12 Endocrinology and Metabolism

SECTION 1 Endocrinology

369 Approach to the Patient with Endocrine Disorders

370 Mechanisms of Hormone Action

371 Physiology of Anterior Pituitary Hormones

372 Hypopituitarism

373 Pituitary Tumor Syndromes

374 Disorders of the Neurohypophysis

375 Thyroid Gland Physiology and Testing

376 Hypothyroidism

377 Hyperthyroidism

378 Thyroid Nodular Disease and Thyroid Cancer

379 Disorders of the Adrenal Cortex

380 Pheochromocytoma

381 Multiple Endocrine Neoplasia

382 Autoimmune Polyendocrine Syndromes

SECTION 2 Sex- and Gender-Based Medicine

383 Disorders of Sex Development

384 Disorders of the Testes and Male Reproductive System

385 Disorders of the Female Reproductive System

386 Menstrual Disorders and Pelvic Pain

387 Hirsutism

388 Menopause and Postmenopausal Hormone Therapy

389 Infertility and Contraception

390 Sexual Dysfunction

391 Women’s Health

392 Men’s Health

393 Lesbian, Gay, Bisexual, and Transgender (LGBT) Health

SECTION 3 Obesity, Diabetes Mellitus, and Metabolic Syndrome

394 Pathobiology of Obesity

395 Evaluation and Management of Obesity

396 Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology

397 Diabetes Mellitus: Management and Therapies

398 Diabetes Mellitus: Complications

399 Hypoglycemia

400 Disorders of Lipoprotein Metabolism

401 The Metabolic Syndrome

SECTION 4 Disorders of Bone and Mineral Metabolism

402 Bone and Mineral Metabolism in Health and Disease

403 Disorders of the Parathyroid Gland and Calcium Homeostasis

404 Osteoporosis

405 Paget’s Disease and Other Dysplasias of Bone

SECTION 5 Disorders of Intermediary Metabolism

406 Heritable Disorders of Connective Tissue

407 Hemochromatosis

408 Wilson’s Disease

409 The Porphyrias

410 Disorders of Purine and Pyrimidine Metabolism

411 Lysosomal Storage Diseases

412 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism

413 Inherited Disorders of Amino Acid Metabolism in Adults

414 Inherited Defects of Membrane Transport

PART 13 Neurologic Disorders

SECTION 1 Diagnosis of Neurologic Disorders

415 Approach to the Patient with Neurologic Disease

416 Neuroimaging in Neurologic Disorders

417 Pathobiology of Neurologic Diseases

SECTION 2 Diseases of the Central Nervous System

418 Seizures and Epilepsy

419 Cerebrovascular Diseases

420 Ischemic Stroke

421 Intracranial Hemorrhage

422 Migraine and Other Primary Headache Disorders

423 Alzheimer’s Disease

424 Frontotemporal Dementia

425 Vascular Dementia

426 Dementia with Lewy Bodies

427 Parkinson’s Disease

428 Tremor, Chorea, and Other Movement Disorders

429 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases

430 Prion Diseases

431 Ataxic Disorders

432 Disorders of the Autonomic Nervous System

433 Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders

434 Diseases of the Spinal Cord

435 Concussion and Other Traumatic Brain Injuries

436 Multiple Sclerosis

437 Neuromyelitis Optica

SECTION 3 Nerve and Muscle Disorders

438 Peripheral Neuropathy

439 Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies

440 Myasthenia Gravis and Other Diseases of the Neuromuscular Junction

441 Muscular Dystrophies and Other Muscle Diseases

SECTION 4 Chronic Fatigue Syndrome

442 Chronic Fatigue Syndrome

SECTION 5 Psychiatric and Addiction Disorders

443 Biology of Psychiatric Disorders

444 Psychiatric Disorders

445 Alcohol and Alcohol Use Disorders

446 Opioid-Related Disorders

447 Cocaine and Other Commonly Used Drugs

448 Nicotine Addiction

PART 14 Poisoning, Drug Overdose, and Envenomation

449 Heavy Metal Poisoning

450 Poisoning and Drug Overdose

451 Disorders Caused by Venomous Snakebites and Marine Animal Exposures

452 Ectoparasite Infestations and Arthropod Injuries

PART 15 Disorders Associated with Environmental Exposures

453 Altitude Illness

454 Hypothermia and Peripheral Cold Injuries

455 Heat-Related Illnesses

PART 16 Genes, the Environment, and Disease

456 Principles of Human Genetics

457 The Practice of Genetics in Clinical Medicine

458 Gene and Cell Based Therapy in Clinical Medicine

459 The Human Microbiome

PART 17 Global Medicine

460 Global Issues in Medicine

461 Worldwide Changes in Patterns of Infectious Disease

462 Primary Care and Global Health

PART 18 Aging

463 The Biology of Aging

464 Clinical Problems Associated with the Aging Process

PART 19 Consultative Medicine

465 Approach to Medical Consultation

466 Medical Disorders During Pregnancy

467 Medical Evaluation of the Surgical Patient

PART 20 Frontiers

468 Behavioral Economics and Health

469 Complementary, Alternative, and Integrative Health Approaches

470 Telomere Disease

471 The Role of Epigenetics in Disease and Treatment

472 Mitochondrial DNA and Heritable Traits and Diseases

473 Applications of Stem Cell Biology in Clinical Medicine

474 Microbial Genomics and Infectious Disease

475 The Role of Circadian Biology in Health and Disease

476 Network Medicine: Systems Biology in Health and Disease

477 Emerging Neurotherapeutic Technologies

Index

 

 Easy to read, superbly illustrated, and clinically relevant, Gray's Anatomy for Students, 4th Edition, is medical students' go-to text for essential information in human anatomy. This fully revised volume focuses on the core information students need to know, in an easy-access format and with additional multimedia tools that facilitate effective study and mastery of the material. A team of expert authors and global advisors share their extensive teaching and clinical experience, highlighted by more than 1,000 innovative, original illustrations throughout the text.

• Helps students understand the practical applications of anatomical concepts through unique coverage of surface anatomy, correlative diagnostic images, and clinical case studies.
• Presents anatomy logically by body region, and now offers bonus eBook chapters for each major body system to facilitate learning from a different perspective - covering the Cardiovascular System, Respiratory System, Gastrointestinal System, Urogenital System, Lymphatic System, and Nervous System.
• Features an all-new eBook chapter covering the essentials of neuroanatomy, so readers can learn key aspects of this challenging topic in the context of general anatomy.
• Offers new schematic drawings for key structures and topics in every chapter, providing an additional, simplified approach to introduce each topic-ideal for quick initial understanding and as a guide for students' own anatomy drawings.
• Includes new and improved online materials such as self-assessment questions, clinical cases, an Interactive Surface Anatomy tool, an online anatomy and embryology self-study course, and more.
• Provides fully revised and updated clinical content including numerous new In the Clinic boxes, plus new clinical cases, images, and correlates throughout.
• Enables readers to quickly review the basic concepts from each chapter with Conceptual Overviews.
• Includes an Enhanced eBook version with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

 

Coordonatorii editiei in limba romana: Prof. Dr. Corin Badiu si Prof. Dr. Cristian Baicus

Unic printre textele medicale, Manualul Oxford de Medicina Clinica (ediția a zecea) reprezinta un material complet si concis pentru specializarile principale ale medicinei si ofera o abordare holistica, centrata pe pacient. Editia a zecea prezinta informatii-cheie actualizate, iar capitolele privind gastroenterologia, bolile infectioase, neurologia si radiologia au fost complet revizuite. Abordarea tematica se suprapune cu evaluarea clasica a fiecarui caz: anamneza si examenul obiectiv, apoi descrierea patologiei pe aparate si sisteme, cu exemple, scheme, tabele si imagini, care aduc valoare practicii medicale.

Apreciat de medici de peste trei decenii, Manualul Oxford de Medicina Clinica continua sa fie un ghid cu adevarat indispensabil pentru practica medicinei moderne.

 Prefata la editia in limba romana

„Pornind de la prima pagina, medicul cu experienta sau in formare descopera un nou prieten: o carte sintetizată, bine organizată tematic, atractiva, care expune intr-o combinatie unica elementele de detaliu privind diagnosticul si tratamentul. Sistematizata in 19 capitole, manualul porneste de la un scurt istoric filozofic al domeniului, luand in discutie repere majore ale filozofiei medicale, dar si aspecte etice importante. Principiile medicinei bazate pe dovezi si ale statisticii medicale fac parte din acelasi capitol initial.

Abordarea tematica se suprapune cu evaluarea clasica a fiecarui caz: anamneză si examenul obiectiv, apoi descrierea patologiei pe aparate si sisteme, cu exemple, scheme, tabele si imagini, care aduc valoare practicii medicale.

Temele speciale sunt evidentiate prin casete specifice, la care se face trimitere ori de cate ori este necesar. Realizate excelent din punct de vedere grafic, imaginile sunt foarte sugestive, intregind armonios informatia din text si tabele. Manualul include informatii de ultima ora, foarte bine structurate in tabele si algoritmi, care ofera practicianului un sprijin permanent in decizia medicala. Din loc in loc se regasesc istorioare din viata curenta a practicianului sau repere istorice ale domeniului, care fac lectura captivanta.

Traducerea carții Oxford Handbook of Clinical Medicine a beneficiat de implicarea unui grup de specialisti entuziasti, care au adaptat informatiile la terminologia clasica romaneasca, realizand un text fluent, atractiv si precis. Multumim tuturor celor care au dedicat timp si energie pentru a face posibila aparitia acestui manual in limba romana.

Sunt convins ca acest volum reprezinta un instrument util atat pentru medicul cu experiența, cat si pentru cel aflat la inceputul carierei, fiecare gasind deopotrivă un prieten de nadejde în Manualul Oxford de Medicina Clinica.

Va dorim lectura placuta!

Prof. Dr. Corin Badiu”

Cuprins:

Conținutul fiecarui capitol este detaliat pe pagina dedicata acestuia.

Prefata la editia in limba romană si la editia a X-a vi

Mulțumiri vii

Simboluri si abrevieri viii

1 Cugetari medicale 0

2 Istoric si examinare 40

3 Patologie cardiovasculara 110

4 Pneumologie 182

5 Endocrinologie 224

6 Gastroenterologie 266

7 Nefrologie 324

8 Hematologie 364

9 Boli infectioase 424

10 Neurologie 506

11 Oncologie si ingrijiri paliative 580

12 Reumatologie 606

13 Chirurgie 636

14 Biochimie clinică 742

15 Sindroame eponime 774

16 Radiologie 800

17 Intervale de referintă si alte aspecte 832

18 Proceduri practice 840

19 Urgente 860

20 Referinte 936

Scorul de avertizare timpurie 952

Stopul cardiac 954