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    Encyclopedia of Cardiovascular Research and Medicine offers researchers over 200 articles covering every aspect of cardiovascular research and medicine, including fully annotated figures, abundant color illustrations and links to supplementary datasets and references. With contributions from top experts in the field, this book is the most reputable and easily searchable resource of cardiovascular-focused basic and translational content for students, researchers, clinicians and teaching faculty across the biomedical and medical sciences. The panel of authors chosen from an international board of leading scholars renders the text trustworthy, contemporary and representative of the global scientific expertise in these domains.

    The book's thematic structuring of sections and in-depth breakdown of topics encourages user-friendly, easily searchable chapters. Cross-references to related articles and links to further reading and references will further guide readers to a full understanding of the topics under discussion. Readers will find an unparalleled, one-stop resource exploring all major aspects of cardiovascular research and medicine.

    Key Features


    ·         Presents comprehensive coverage of every aspect of cardiovascular medicine and research

    ·         Offers readers a broad, interdisciplinary overview of the concepts in cardiovascular research and medicine with applications across biomedical research

    ·         Includes reputable, foundational content on genetics, cancer, immunology, cell biology and molecular biology

    ·         Provides a multi-media enriched color-illustrated text with high quality images, graphs and tables.



    Students at upper undergraduate and graduate level. Established academics and clinicians involved in the research and treatment of cardiovascular diseases. Students and professionals engaged in biomedical research or training in/practicing clinical medicine. Students, researchers, clinicians, and teaching faculty across the biomedical and medical sciences

    About the Editor-in-Chief

    Douglas Sawyer

    Physician-scientist with focus on heart failure leading research and training program developing novel insights into pathophysiology of cardiovascular disease and innovative strategies to prevent and treat advanced heart failure.

    Affiliations and Expertise

    Maine Medical Center

    Ramachandran Vasan

    Vasan is a noninvasive cardiologist with specialization in cardiovascular epidemiology, and a senior investigator at the Framingham Heart Study. He is the co-director of the echocardiography and vascular testing laboratory at the Framingham Heart Study and he directs its fellowship training program. His epidemiological research has focused on 4 inter-related areas: a. the epidemiology of congestive heart failure, including identifying risk factors for the disease, characterizing the subgroups with diastolic heart failure, asymptomatic LV systolic and diastolic dysfunction, and evaluating the role of LV remodeling; b. population-based vascular testing and echocardiography, including identifying biological, environmental, and genetic determinants (correlates) of cardiac structure and function; normative standards; detailed assessment of biomarkers of the process of LV remodeling; c. epidemiology of high blood pressure, including characterizing the lifetime risk, rates of progression and risks associated with various degrees of elevation; and, d. exercise physiology, and exercise test responses in asymptomatic individuals and prognostic information; relations to endothelial function.

    Affiliations and Expertise

    Senior Investigator and Co-Director, Echocardiography and Vascular Testing Laboratory, Framingham Heart Study

    Table of Contents

    Basic cardiovascular anatomy, physiology, pathology and pharmacology
    Basic vascular biology
    Molecular biology and genetics/genomics in cardiovascular medicine
    Cardiovascular epidemiology and preventive cardiology
    Evaluative and treatment of cardiovascular disease, and clinical research methods
    Atherosclerotic cardiovascular disease
    Heart failure and cardiomyopathies
    Cardiac electrophysiology, arrhythmias and sudden death
    Diseases of pericardium, great vessels, pulmonary circulation and miscellaneous cardiovascular disorders
    Heart disease in special populations and cardiac involvement in systemic diseases

    Article Titles:


    Adult Congenital Heart Disease, Pages 1-9, D. Briston, E. Bradley

    Adverse Impact of Delayed Electrical Activation of the Heart and Benefits of Cardiac Resynchronization, Pages 10-33, A. Guha, E.G. Daoud

    AL Cardiac Amyloidosis: Classification, Diagnosis, and Treatment, Pages 34-48, O.K. Siddiqi, F.L. Ruberg

    Alcohol, Pages 49-57, C. Matsumoto

    Alcoholic Cardiomyopathy, Pages 58-65, A. Voiosu, S. Wiese, J.D. Hove, T. Voiosu, F. Bendtsen, S. Møller

    Amyloid Cardiomyopathy, Pages 66-79, T. Sher, M.A. Gertz

    Anemia in Heart Failure, Pages 80-84, A. Patel, N.L. Altman

    Angiogenesis, Pages 85-96, N. Warmke, A.M.N. Walker, R.M. Cubbon

    Animal Models of Ischemic Heart Disease: From Atherosclerosis and Thrombosis to Myocardial Infarction, Pages 97-110, R. Covarrubias, A.S. Major, R.J. Gumina

    Ankle-Brachial Pressure Index and Pulse Wave Velocity in Cardiovascular Risk Assessment, Pages 111-122, H. Tomiyama, A. Yamashina

    Aortic Aneurysm, Pages 123-142, M. Singh, B.A. Ziganshin, J.A. Elefteriades

    Aortic Valve Replacement in Patients With Congestive Heart Failure, Pages 143-161, V.J. Nardy, J.A. Crestanello, N.P. Jaik

    Arrhythmias in Cancer and Cancer Treatment: A Review, Pages 162-181, D. Haddad, A. Guha, F. Awan, E.G. Daoud, R. Baliga

    Arrhythmogenic Right Ventricular Cardiomyopathy, Pages 182-191, M.R Afzal, C. Evanson, A. Cardona, K. Rusk, R. Weiss

    Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy, Pages 192-204, G.M. Orgeron, H. Calkins

    Athlete's Heart, Pages 205-211, L.M. Safi, M.J. Wood

    Atrial Tachycardia—Mechanisms and Management, Pages 212-223, J. Ahmed, P. LeLorier

    Atrioventricular Node Reentrant Tachycardia, Pages 224-241, A.G. Carrizo, B. Ballantyne, A. Baranchuk

    ATTR Cardiac Amyloidosis: Classification, Diagnosis, and Management, Pages 242-256, J.A. Cowgill, J.N. Wight Jr.

    Behavior Modification and Cardiovascular Disease, Pages 257-262, V. Ramirez, B. Starobin, J. Monti

    Bicuspid Aortic Valve and Sports Activity, Pages 263-272, L. Stefani, G. Galanti, N. Maffulli

    Bioinformatics Principles for Deciphering Cardiovascular Diseases, Pages 273-292, L. Shu, D. Arneson, X. Yang

    Biomarkers in Heart Failure, Use of, Pages 293-302, P.U. Gandhi

    Biomarkers in Ischemic Heart Disease, Pages 303-314, J.T. Neumann, R.B. Schnabel

    Biomarkers: Heart Failure, Pages 315-322, S.S. Gogia, J.E. Ho

    Biomarkers: Population Screening and Risk-Stratification, Pages 323-333, I. Ratjen, R.S. Vasan, W. Lieb

    Biophysics of Ablation—Radiofrequency and Cryoablation, Pages 334-349, J.G. Andrade, M.W. Deyell, L. Macle

    Blood Pressure Variability Versus Blood Pressure Level in Risk Stratification, Pages 350-355, F.-F. Wei, K. Asayama, A. Hara, T.W. Hansen, Y. Li, J.A. Staessen

    Brugada Syndrome, Pages 356-372, C. Antzelevitch

    Cardiac Anatomy, Physiology, and Pathophysiology, Pages 373-383, K.N. Hor, A.J. Trask

    Cardiac and Induced Pluripotent Stem Cells, Pages 384-393, A. Salerno, W. Balkan, K. Hatzistergos, J.M. Hare

    Cardiac Arrhythmia in Heart Failure, Pages 394-410, T. Okabe, S.J. Kalbfleisch

    Cardiac Biomechanics in Normal Physiology and Disease, Pages 411-419, K.M. Broughton

    Cardiac Fibroblast, Pages 420-433, J. Park, M.D. Tallquist

    Cardiac Hypertrophy: Signaling and Cellular Crosstalk, Pages 434-450, D. Tirziu

    Cardiac Magnetic Resonance Imaging in Heart Failure, Pages 451-462, A. Reynolds, K.M. Zareba

    Cardiac Pacing and Monitoring: Past, Present, and Future, Pages 463-467, F. Chalhoub, T. Mela

    Cardiac Regeneration and Stem Cells as Therapy for Heart Disease, Pages 468-474, A.J. Favreau-Lessard, D.B. Sawyer

    Cardiac Resynchronization Therapy, Pages 475-488, G. Voros

    Cardiac Transplantation, Pages 489-513, A. Hasan

    Cardiohepatic Interactions, Pages 514-522, J. Shah, E. Shao

    Cardiopulmonary Exercise Testing, Pages 523-526, V. Franco

    Cardiovascular Complications and Management in Sarcoidosis: A Review, Pages 527-534, D.J. Roberts, S. Francis, J.A. Rosenblatt, S.T. Coffin

    Cardiovascular Disease and Obesity, Pages 535-541, Y. Matsushita

    Catecholaminergic Polymorphic Ventricular Tachycardia, Pages 542-552, P.J. Kannankeril

    Catheter Ablation for Atrial Fibrillation (Methods), Pages 553-565, J.G. Andrade, M.W. Deyell, L. Macle

    Catheter Ablation for Ventricular Tachycardia, Pages 566-575, R.M. John, W.G. Stevenson

    Cellular Sinoatrial Node and Atrioventricular Node Activity in the Heart, Pages 576-592, H.J. Jansen, T.A. Quinn, R.A. Rose

    Chronic Infections of the Heart, Pages 593-599, M. Edwards, C. Withers, K. Thakarar

    Chronic Kidney Disease as a Risk Factor for Cardiovascular Disease, Pages 600-608, T. Ninomiya

    Clinical Assessment of the Cardiac Arrhythmia Patient, Pages 609-619, B. Olshansky

    Clinical Management of Inherited Arrhythmias, Pages 620-629, R.L. Jones, M.V. Perez

    Clinical Trials for Atrial Fibrillation—What Do We Know?, Pages 630-642, D.S. Chew, S.B. Wilton

    Complications of Pregnancy and Future Cardiovascular Risk, Pages 643-650, P.H. Andraweera, G.A. Dekker, M. Arstall, T. Bianco-Miotto, C.T. Roberts

    Comprehensive Lifestyle Modification for Hypertension and Lifestyle-Related Disease Under the New Guidelines, Pages 651-658, Y. Kokubo, C. Matsumoto

    Computational Systems Biology for the VEGF Family in Angiogenesis, Pages 659-676, J.C. Weddell, P.I. Imoukhuede

    Congenital Heart Valve Disease in the Adult, Pages 677-690, A. Luk, J. Alvarez, J. Butany

    Coronary Anatomy, Pages 691-699, M. Sivananthan

    Coronary Artery Bypass Grafting, Pages 700-729, R.S. Kramer, J.R. Morton, R.C. Groom, D.L. Robaczewski

    Cyanotic Congenital Heart Disease, Pages 730-747, M.S. Renno, J.A. Johns

    Dairy Products and Cardiovascular Diseases, Pages 1-8, M. Yanagi, N. Amano, T. Nakamura

    Diabetes Mellitus, Pages 9-16, H. Sone

    Diagnosis and Imaging of Congenital Heart Disease, Pages 17-46, S.R. Fuchs, J.H. Soslow

    Diagnosis of Non-ST-Elevation Myocardial Infarction (NSTEMI), Pages 47-53, M. Vafaie, E. Giannitsis

    Diet in Heart Failure, Pages 54-59, M. Rozmahel, E. Colin-Ramirez, J.A. Ezekowitz

    Dietary Fat and Risk of Cardiovascular Disease, Pages 60-89, E.S. Eshak, K. Yamagishi, H. Iso

    Digital Data (mHealth and Social Media), Pages 90-97, R. Bhattacharjee, T. Hussein

    Diseases of the Mitral Valve, Pages 98-106, L. Mc Carthy, P. Collier

    Diuretic Therapy, Pages 107-116, A. Vazir, V. Sundaram, A.R. Harper

    Driving and Syncope, Pages 117-125, D. Sorajja, W.-K. Shen

    Echocardiography in Heart Failure, Pages 126-141, T. Chen, J.N. Kirkpatrick

    Echocardiography: Assessment of Valve Structure and Function, Pages 142-186, S. Vallurupalli, A. Siraj, S. Kenchaiah

    Economics of Heart Failure, Pages 187-196, S. Stewart, C. Mainland, A. David

    Electrocardiographic Monitoring Strategies (Holter, Implantable Loop Recorder, in Between), Pages 197-210, H. Nazzari, L. Halperin, A.D. Krahn

    Electrophysiology Approaches for Ventricular Tachycardia, Pages 211-220, R.M. John, W. Stevenson

    Emergency Medicine Approach and Management of Traumatic Injuries: An Overview, Pages 221-230, E. Lavine, E. Legome

    Environmental Air Pollution: An Emerging Risk Factor for Stroke, Pages 231-237, B. Delpont, A.S. Mariet, C. Blanc, Y. Bejot, M. Giroud, J. Reis

    Environmental Risk Factors for Stroke and Cardiovascular Disease, Pages 238-247, J. Reis, M. Giroud, Y. Kokubo

    Epidemiology of Atherosclerotic Cardiovascular Disease, Pages 248-257, N. Townsend

    Epigenomics, Pages 258-265, T.A. Turunen, M.-A. Väänänen, S. Ylä-Herttuala

    Exercise and Cardiac Rehabilitation in Heart Failure, Pages 266-273, S.R. Schubert

    Exercise, Physical Activity, and Cardiovascular Disease, Pages 274-280, A. Bauman, M. Alharbi, N. Lowres, R. Gallagher, E. Stamatakis

    Oxygenation, Pages 281-284, A. Kilic

    Familial Hypercholesterolemia, Pages 285-297, A. Pirillo, A.L. Catapano

    Frailty in Heart Failure Patients, Pages 298-302, S. Pedraza, T.A. Barrett, C.M. Hritz

    Genetic Atrial Fibrillation, Pages 303-312, R. Chia, A. Mehta, H. Huang, D. Darbar

    Genetic Disorders Involving Valve Function, Pages 313-326, M. Afshar, G. Thanassoulis

    Genetic Disorders of the Vasculature, Pages 327-367, A.J. Brownstein, B.A. Ziganshin, J.A. Elefteriades

    Genetics of Heart Failure, Pages 368-379, A. Briasoulis, R. Asleh, N. Pereira

    Heart Development, Pages 380-398, E. Dees, S. Baldwin

    Heart Failure in African Americans, Pages 399-405, M. Jame, S. Jame, M. Colvin

    Heart Failure in Cancer Patients, Pages 406-416, A. Vallakati, B. Konda, R. Baliga

    Heart Failure in Low- to Middle-Income Countries, Pages 417-428, S. Stewart, F. Taylor, A.K. Keates

    Heart Failure in Minorities, Pages 429-436, E.R. Fox, M.E. Hall, J.D. Pollard, S.K. Musani, C.J. Rodriguez, R.S. Vasan

    Heart Failure in the Elderly, Pages 437-452, S. Katsanos, J. Parissis

    Heart Failure Monitoring, Pages 453-463, E.S. Shao

    Heart Failure With Preserved Ejection Fraction, Pages 464-468, S. Day

    Heart Regeneration with Stem Cell Therapies, Pages 469-483, M. Natsumeda, B.A. Tompkins, V. Florea, A.C. Rieger, M. Banerjee, W. Balkan, J.M. Hare

    Heart–Lung Transplantation, Pages 484-488, B. LeNoir, M. Malik, B.A. Whitson

    Hemodynamic Changes of Pregnancy, Pages 489-496, P. Divanji, N.I. Parikh

    Hemodynamics of the Right Heart in Health and Disease, Pages 497-507, D.M. Gopal, A. Alsamarah

    Hormonal Therapy in the Treatment of Chronic Heart Failure, Pages 508-516, R. Napoli, A. Salzano, E. Bossone, A. Cittadini

    Hypertensive Heart Disease, Pages 517-526, M.U. Moreno, A. González, B. López, S. Ravassa, J. Beaumont, G. San José, R. Querejeta, J. Díez

    Hypertrophic Cardiomyopathy, Pages 527-532, L.K. Williams

    Imaging of Mitral Regurgitation, Pages 1-11, J.B. Strom, K.F. Faridi, C.W. Tsao

    Imaging: CT Scanning of the Heart and Great Vessels, Pages 12-34, M. Eid, M.H. Albrecht, C.N. De Cecco, D. De Santis, A. Varga-Szemes, D. Caruso, V.W. Lesslie, U.J. Schoepf

    Imaging: Echocardiology—Assessment of Cardiac Structure and Function, Pages 35-54, D. Bamira, M.H. Picard

    Immune Mechanisms in Cardiac Physiology, Pages 55-67, S.M. Peterson, D.J. Roberts, S. Ryzhov

    Immune-Mediated Mechanisms of Atherosclerosis, Pages 68-76, M. Bäck, D.F.J. Ketelhuth, S. Malin, P.S. Olofsson, G. Paulsson-Berne, Z.-Q. Yan, G.K Hansson

    Implanted Pacemakers—Indications and Novel Programming, Pages 77-86, R. Willems

    Induced Pluripotent Stem Cell–Derived Cardiomyocytes in Advancing Cardiovascular Medicine, Pages 87-93, C. Zhang, A.G. Cadar, C.C. Hong

    Infective Endocarditis in 21st Century, Pages 94-101, V.V. Kandasamy, S. Pant, J.L. Mehta

    Inflammatory and Infectious Disorders of the Aorta, Pages 102-107, V. Noori, B. Nolan, C. Healey

    Inotropes in Heart Failure, Pages 108-118, M. Ginwalla, C. Bianco

    Interventions: Endomyocardial Biopsy, Pages 119-125, B. Kherad, U. Kühl, C. Tschöpe

    Intra-aortic Balloon Pumps (IABP) and Percutaneous Ventricular Assist Devices (VADs), Pages 126-131, N.K. Kapur, M.L. Esposito

    Ion Channelopathy Genetics, Pages 132-144, A. Adler, M.H. Gollob

    Ischemic Cardiomyopathy, Pages 145-154, S. Airhart, S. Murali

    Kidney in Heart Failure, Pages 155-165, D.N. Pratt, A. Diez

    Lead-Related Complications, Pages 166-170, B. Mondesert, R. Parkash

    Left and Right Ventricular Remodeling, Pages 171-185, D. Pinkhas, X. Gao

    Left Ventricular Assist Device (LVAD) and Circulatory Devices in Heart Failure, Pages 186-199, P. Lee

    Left-Sided Obstructive Congenital Heart Lesions: Including Hypoplastic Left Heart, Pages 200-213, C.J. Prendergast, G.T. Nicholson

    Lipid-Mediated Mechanisms in Atherosclerosis, Pages 214-220, Q. Liu, J. Martinez, J. Hodge, D. Fan

    Lipids and Cardiovascular Diseases: Epidemiologic Perspectives, Pages 221-229, T. Okamura, D. Sugiyama, T. Hirata, K. Kuwabara, A. Hirata

    Long QT Syndrome and Torsade de Pointes, Pages 230-244, N. El-Sherif, G. Turitto, M. Boutjdir

    Management and Care of Older Cardiac Patients, Pages 245-265, A.A. Damluji, A. Ramireddy, D.E. Forman

    Management of Cardiac Sarcoidosis, Pages 266-273, L. Alghothani, E.D. Crouser

    Management of Patients With Implantable Cardiac Devices Referred for Magnetic Resonance Imaging: A Rapidly Changing Landscape, Pages 274-281, I. Roifman, J.A. White

    Management of Pregnancy With Underlying Congenital and Acquired Cardiac Disease, Pages 282-291, A.M. Moran

    Management of Ventricular Tachycardia in Ischemic and Nonischemic Cardiomyopathy, Pages 292-301, A. AbdelWahab, V.P. Kuriachan, G.L. Sumner, L.B. Mitchell, J. Sapp

    Managing Cardiovascular Disease in Sport and Athletes, Pages 302-315, A.B. Shah, A.L. Baggish

    Mechanisms of Cardiac Arrhythmias: Molecular and Cellular Perspective, Pages 316-327, P Zhabyeyev, G.Y. Oudit

    Medical Management of Left Ventricular Assist Devices, Pages 328-330, S. Emani

    Metabolomics in Cardiovascular Research, Pages 331-339, V. Salomaa, M. Inouye

    MicroRNAs in Cardiac Development and Function, Pages 340-348, Y Tian

    Microvasculature in Health and Disease, Pages 349-364, J.E. Beare, L. Curtis-Whitchurch, A.J. LeBlanc, J.B. Hoying

    Mitochondrial Bioenergetics in the Heart, Pages 365-380, E.J. Lesnefsky, Q. Chen, B. Tandler, C.L. Hoppel

    Modern Considerations in ICD Therapy, Pages 381-387, T.D. Richardson, C.R. Ellis

    MR Imaging of the Heart and the Great Vessels, Pages 388-403, U. Neisius, C. Tsao

    Myocardial Perfusion Imaging, Pages 404-424, R.B. Morgan

    Myocardial Repair, Pages 425-439, K. Breckwoldt, T. Eschenhagen

    Myocarditis, Pages 440-451, A.L.P. Caforio, G. Malipiero, R. Marcolongo, S. Iliceto

    Myocarditis in Heart Failure, Pages 452-458, G. Sinagra, J. Artico, P. Gentile, E. Fabris, R. Bussani, A. Cannatà, M. Merlo

    Neurohormonal Blockade, Pages 459-476, L. Cunningham, W. Kayani, A. Deswal

    Neurological Regulation of the Circulation, Pages 477-491, D.N. Jackson, N.M. Novielli, J. Twynstra

    Noninfective Inflammatory Disorders of the Pericardium, Pages 492-501, B. Ravaee, B.D. Hoit

    Non-ST-Elevation Acute Coronary Syndrome Prognosis, Pages 502-521, H. Haghbayan, C.P. Gale, A.T. Yan

    Non-ST-Elevation Myocardial Infarction: Management, Pages 522-530, M. Cimci, B. Gencer, M. Roffi

    Nutrition—Macronutrients, Pages 531-537, T. Nakamura, S. Kuranuki

    Nutrition: Soy and Fish, Pages 538-545, Y. Yamori, M. Sagara, H. Mori, M. Mori

    Obesity and the Obesity Paradox in Heart Failure, Pages 546-564, A.A. Oktay, C.J. Lavie, H.O. Ventura

    Oral Health and Cardiovascular Disease: Recent Findings and Future View With a Novel Aspect, Pages 565-572, T. Ono, M. Kida, T. Kosaka, M. Kikui

    Orthostatic Hypotension and Vasovagal Syncope, Pages 573-591, B.H. Shaw, J. Ng, S.R. Raj

    Palliative Care in Advanced Heart Failure, Pages 1-7, M. Ginwalla, B.P. Dhakal

    Pediatric Catheter Ablation, Pages 8-36, A.E. Radbill, F.A. Fish, T.P. Graham Jr.

    Perioperative Management in Heart Failure, Pages 37-41, C. Mayeur, A. Mebazaa

    Peripartum Cardiomyopathy, Pages 42-48, L.J. Hassen, S. Roble

    Peripheral Arterial Disease, Pages 49-59, K. Matsushita, A. Barleben, M. Allison

    Pharmacogenomics of Antiarrhythmic Drug Therapy for Atrial Fibrillation, Pages 60-67, D. Darbar

    Pharmacology of Medications Used in the Treatment of Atherosclerotic Cardiovascular Disease, Pages 68-88, R. Khatib, F. Wilson

    Physical Examination: Heritable Cardiovascular Syndromes, Pages 89-105, K. Puri, J.P. Zachariah

    Physical Examination: Normal Examination in Adult Acquired and Congenital Heart Disease, Pages 106-115, T.R. Schlingmann, J.P. Zachariah

    Physiological Adaptations of the Heart in Elite Athletes, Pages 116-124, A. D’Andrea, J. Radmilovich, L. Riegler, R. Scarafile, B. Liccardo, T. Formisano, A. Carbone, R. America, F. Martone, M. Scherillo, M. Galderisi, R. Calabrò

    Practical Guide to Evidence-Based Management of Heart Failure in the Outpatient Setting, Pages 125-142, A.M. Maw, R.L. Page II, R.S. Boxer

    Preclinical Cardiovascular Imaging, Pages 143-153, I. Pinz

    Preeclampsia and Hypertension in Pregnancy, Pages 154-159, N. Jafar, N. Hippalgaonkar, N.I. Parikh

    Pregnancy and Cardiovascular Disease, Pages 160-165, R. Neki

    Proteomics, Pages 166-180, G. Suna, M. Mayr

    Pulmonary Arterial Hypertension, Pages 181-194, R. El Yafawi, M.E. Knauft, K. Stokem, J.M. Palminteri, J.A. Wirth

    Pulmonary Embolism, Pages 195-203, S.C. Berngard, J. Mandel

    Pulmonary Hypertension, Pages 204-222, D.R. Fraidenburg, J.X.-J. Yuan

    Pulmonary Hypertension Associated With Left-Sided Heart Disease, Pages 223-229, D.N. Tukaye, V. Franco

    Quality Indicators for the Management of Acute Myocardial Infarction, Pages 230-239, O. Bebb, M. Hall, C. Gale

    Recreational Drugs: Effects on the Heart and Cardiovascular System, Pages 240-248, B. Starobin, S. Jablonski, A.M. Andrle, J.B. Powers

    Relationship Between Vegetables and Fruits (Antioxidant Vitamins, Minerals, and Fiber) Intake and Risk of Cardiovascular Disease, Pages 249-283, J Ishihara, M Umesawa, C Okada, Y Kokubo, H Iso

    Remission and Recovery in Heart Failure, Pages 284-291, J.S. Guseh, J.E. Ho

    Remote Monitoring of Cardiovascular Implantable Electronic Devices, Pages 292-297, B. Plourde, R. Parkash

    Right Heart Catheterization, Pages 298-306, B.C. Lampert

    Risk Factors for Cardiovascular Disease, Pages 307-314, E.J. Teufel

    Risk Prediction, Pages 315-318, H. Yatsuya

    Role of Coronary Artery Revascularization in Heart Failure, Pages 319-322, B. Shukrallah, A. Kilic, T. Lescouflair

    Role of Digoxin in Heart Failure, Pages 323-326, A. Bucca

    Role of Echocardiography in Selection, Implantation, and Management of Left Ventricular Assist Device Therapy, Pages 327-344, M. Dandel, R. Hetzer

    Salt and Blood Pressure, Pages 345-350, Y. Yano

    Sex and Gender Differences in Cardiovascular Disease, Pages 351-367, L. Mathews, P. Chandrashekar, M. Prasad, V.M. Miller, K. Sharma, T. Sedlak, C.N. Bairey Merz, P. Ouyang

    Sex Differences in the Physiology and Pathology of the Aging Heart, Pages 368-376, A. Ghimire, A.E. Kane, S.E. Howlett

    Signaling in Cardiac Physiology and Disease, Pages 377-387, S. Mukherjee, S. Srikanthan, S.V. Naga Prasad

    Sinus Tachycardias: Inappropriate Sinus Tachycardia and Postural Tachycardia Syndrome, Pages 388-403, B.H. Shaw, J. Ng, S.R. Raj

    Skeletal Muscle in Heart Failure, Pages 404-423, S. Scheetz, R. Baliga

    Sleep and Circadian Cardiovascular Medicine, Pages 424-437, K. Kario

    Sleep-Disordered Breathing and Heart Failure Interactions and Controversies, Pages 438-441, W.J. Healy, R. Khayat

    Socioeconomic Factors and CVD, Pages 442-445, M. Kabayama, K. Kamide

    Stage A Heart Failure: Identification and Management of Heart Failure Risk Factors, Pages 446-455, K.M. Alexander, M. Nayor

    Stage B Heart Failure, Pages 456-464, J. Aljabban, R. Baliga, I. Aljabban

    STEMI: Diagnosis, Pages 465-473, P.E. Puddu, E. Cenko, B. Ricci, R. Bugiardini

    STEMI: Management, Pages 474-488, R. Beatrice, M. Olivia, E. Cenko, R. Bugiardini

    STEMI: Prognosis, Pages 489-498, E. Cenko, B. Ricci, R. Bugiardini

    Structure and Function of the Adult Vertebrate Cardiovascular System, Pages 499-510, J.D. Schultz, D.M. Bader

    Sudden Cardiac Death, Pages 511-520, G.L. Sumner, V.P. Kuriachan, L.B. Mitchell

    Surgical Management of Atrial Fibrillation, Pages 521-532, G. Shanmugam, D. Exner, R. Damiano

    Takotsubo Syndrome, Pages 533-536, M.H. Tranter, A.R. Lyon

    Tobacco and Cardiovascular Diseases, Pages 537-544, H. Kanda, T. Hisamatsu

    Total Artificial Heart, Pages 545-557, T. Lee, G. Torregrossa

    Transcriptomics in Cardiovascular Medicine, Pages 558-571, D. Börnigen, T. Zeller

    Transcriptome and Epigenome Applications for Coronary Heart Disease Research, Pages 572-581, R. Joehanes

    Transplant Arteriosclerosis, Pages 582-592, J.C. Choy

    Trends in the Incidence and Mortality of Cardiovascular Disease, Pages 593-599, J. Hata

    Ultrafiltration for the Treatment of Acute Decompensated Heart Failure, Pages 600-605, S. Emani

    Unstable Angina: Presentation, Diagnosis, and Management, Pages 606-615, P. Manning, E.H. Awtry

    Vascular Guidance Cues, Pages 616-626, D. Valdembri, G. Serini, N. Gioelli

    Vascular Repair at the Interface of the Endothelium: The Roles of Protease-Activated Receptors and Neuregulin-1, Pages 627-639, C.L. Galindo, O. Odiete, J.H. Cleator

    Vasculogenesis in Development, Pages 640-653, S.C. Chetty, K. Choi, S. Sumanas

    Ventricular Arrhythmias and Sudden Cardiac Death in Hypertrophic Cardiomyopathy, Pages 654-663, M.A. Cain, M.S. Link

    Ventricular Assist Devices and Heart Transplantation, Pages 664-673, A. Kinsella, Y. Moayedi, V. Rao, H.J. Ross, J. Butany

    Ventricular Fibrillation and Defibrillation, Pages 674-682, H. Kawata, U. Birgersdotter-Green

    Ventricular Remodeling in Heart Failure, Pages 683-689, I. Aquila, A.M. Shah

    Ventricular Tachycardia in Ischemic and Dilated Cardiomyopathy: Mechanisms and Diagnosis, Pages 690-699, V.P. Kuriachan, G.L. Sumner, A.A. Wahab, J. Sapp, L.B. Mitchell

    Ventricular Tachycardia in Structurally Normal Hearts, Pages 700-724, A.G. Bhatt, S. Mittal

    Wide QRS Complex Tachycardia: What is the Diagnosis?, Pages 725-746, S. Wang, F.R. Quinn

    Wolff–Parkinson–White and Preexcitation Syndromes, Pages 747-758, B. Brembilla-Perrot

    Zebrafish, Pages 759-770, X.-X.I. Zeng, T.P. Zhong

    Zebrafish as a Tool to Study Congenital Heart Diseases, Pages 771-778, A.M. Shafik, D. Cifuentes

  • 7,86400lei 6700.00 lei

    This book covers all liver tumors and lesions that clinically and radiologically mimic liver tumors. It provides readers with a comprehensive overview of this complex and rapidly evolving field. All aspects of surgical pathology are addressed, supplemented by detailed presentations of the lesions’ cell-biologic and molecular features. In addition, the methods employed for diagnosis and diagnostic algorithms are discussed. It appeals to pathologists and hepatologists and serves as an invaluable aid to diagnosis.The field of liver tumors and tumor-like lesions in adults and children has experienced tremendous advances in recent years.

    Specifically, the recognition of novel entities, deepened insights into known tumors, and refinement of classifications have necessitated continual updates and reappraisals. In addition, previous understanding of hepatic carcinogenesis and tumor progression has been transformed by the very rapid evolution of our understanding of cell biology, genomics, signaling pathways, cell interactions, and mechanisms of invasion and spread of hepatic tumor cells. These general pathology issues must be combined with surgical pathology if a comprehensive understanding of liver tumor pathology is to be achieved.

    About the authors

    Professor Arthur Zimmermann is an internationally known specialist in hepatobiliary tumor pathology. After his training as pathologist at the University of Berne, he worked in basic research for several years, focusing on tumor cell growth regulation, tumor cell locomotion and protein kinase signaling. As acting director of the Institute of Pathology of the University of Berne (more than 150 persons work in diagnostics, basic research and student teaching), he implemented the most modern methods of cell biology and genome studies. Professor Zimmermann analyzed more than 20'000 liver specimens, detected several new tumor entities, and was an author or coauthor of more than 500 publications in this field.

    Furthermore, he was one of the editors of the very successful book Pediatric Liver Tumor (Pediatric Oncology Series Book, Springer, 2011). As chapter author, he participated in several well-known books, including Blumgart's Surgery of the Liver and Biliary tract, the Oxford Textbook of Oncology (2nd ed., Oxford Univ.Press, 2002), Felix Lee's Liver Cancer : New Research (Nova Publishers, 2006), Bleyer and Barr's Cancer in Adolescents and Young Adults (Springer, 2007), Rodés's Textbook of Hepatology (Blackwell, 2007), the WHO Classification of Tumors of the Digestive System (2010 edition), Saxena's Practical Hepatic Pathology (Elsevier, 2011 ), and Pizo and Poplack's Principles and Practice of Pediatric Oncology ( Lippincott, Williams and Wilkins, 2011 ). Professor Zimmermann developed the world pathology review center for the multinational SIOPEL liver cancer treatment studies. Together with COG, SIOPEL is the largest Study Group for liver cancer in children, and many hundreds of patients are currently taken care of worldwide. In his function as head of the review and consulting center, Professor Zimmermann developed a new classification of pediatric liver tumors (the SIOPEL Classification).


  • 6140.00 lei

    Available as a 6-vol set

    Fully updated to meet the demands of the 21st-century surgeon, Plastic Surgery, 3e, provides you with the most current knowledge and techniques, allowing you to offer every patient the best possible outcome. Edited b

  • British pharmacopoeia 2020
    La comanda in aproximativ 4 saptamani
    5,77500lei 5600.00 lei


    New, legally enforced standards, become legally effective on 1 January 2020.

    All European Pharmacopoeia texts included.


    Updated annually, the British Pharmacopoeia (BP) is the only comprehensive collection of authoritative official standards for UK pharmaceutical substances and medicinal products.

    It includes approximately 4,000 monographs which are legally enforced by the Human Medicines Regulations 2012. Where a BP monograph exists, medicinal products or active pharmaceutical ingredients sold or supplied in the UK must comply with the relevant monograph.

    All monographs and requirements of the European Pharmacopoeia (Ph. Eur.) are reproduced in the BP, making the BP a convenient and fully comprehensive set of standards that can be used across Europe and beyond.


    New for the BP 2020:


    The BP 2020 supersedes the BP 2019 and becomes legally effective on 1 January 2020. This edition incorporates new monographs from both the BP and Ph. Eur. along with a significant number of revised monographs.


    ·         35 new BP monographs, 40 new Ph. Eur monographs

    ·         331 amended BP monographs

    ·         Five new monographs for unlicensed formulations, two new monographs for herbal medicines

    ·         One new and one amended BP Veterinary monographs

    ·         All monographs from the Ph. Eur. 9th edition including Supplements 9.1 to 9.8

    ·         Three in-year online and offline download product updates to integrate the Ph. Eur. Supplements 10.0, 10.1 and 10.2.  


    The BP 2020 complete package:


    The complete package is a great value-for-money option including:

    A six-volume hard copy (printed) edition, including the BP (Veterinary) 2020

    A single-user online licence* for BP Online

    A single-user download for offline use*



  • Plastic Surgery: 6-Volume Set, 4th Edition
    La comanda in aproximativ 4 saptamani
    6,61500lei 5300.00 lei

    Comprehensive in scope, the 6-volume Plastic Surgery, 4th edition returns as the ultimate knowledge source in this most challenging of surgical specialties. It’s been completely revised to meet the demands of the trainee and practicing plastic surgeon, featuring brand-new color clinical photos, procedural videos, and lectures across all 6 volumes. Bonus material that includes additional text, images, and videos helps you improve your mastery of the latest techniques.


    • Each easily readable, individual volume is a standalone comprehensive text full of salient and applicable anatomy and techniques.
    • Bonus online material includes additional text, images, and over 150 procedural videos.
    • Lead editor Peter C. Neligan creates a cohesive tone throughout the chapters and content across all 6 volumes.
    • Evidence-based advice from a diverse collection of experts allows you to apply the very latest advances in every area of plastic surgery and ensure optimal outcomes.
    • Easily find the answers you need with an organization that features separate volumes covering Principles • Aesthetic • Craniofacial, Head and Neck Surgery and Pediatric Plastic Surgery • Lower Extremity, Trunk and Burns • Breast • and Hand and Upper Extremity.
      • Principles volume covers: Digital technology in plastic surgery; Repair and grafting of fat and adipose tissue; Stem cell therapy and tissue engineering; and Treatment of Lymphedema
      • Aesthetic volume covers: Facelift - The male patient; Energy-based devices for body contouring; Autologous gluteal flaps for augmentation and preservation of gluteal contour; Buttock shaping with fat grafting and liposuction; and Essential elements of patient safety in Aesthetic Plastic Surgery, just to name a few.
      • Craniofacial and Pediatric Plastic Surgery volume covers: Computerised surgical planning in orthognathic surgery; Computerised surgical planning in craniofacial, head and neck surgery; and Rotation advancement.
      • Breast volume covers: Device considerations in breast augmentation, breast implant-associated anaplastic large-cell lymphoma, surgical management of post-mastectomy lymphedema, gynecomastia surgery, and radiation therapy in the setting of breast reconstruction.
      • Lower Extremity, Trunk and Burns volume covers: Lymphedema microsurgery; Transgender surgery; and Skin grafting and reconstructive surgery for burns.
      • Hand and Upper Extremity volume covers: Pediatric and adult hand surgery; Nerve transfers; Tendon repair; and Functional prosthetics.

    Purchase one volume individually or own the entire set, with the ability to search across all six volumes online!

    New To This Edition:

    • More than 50 new video lecture presentations offer a step-by-step audio-visual walkthrough of techniques and procedures across all volumes.
    • Brand-new videos cover such groundbreaking procedures as face transplant surgery; lymphedema surgery; bariatric surgery and lipoabdominoplasty and buttock augmentation; and much more.
    • Aesthetic content has been completely updated by acclaimed editor, J. Peter Rubin; the Breast volume has been completely reworked by editor Maurice Nahabedian, and now covers all aesthetic and reconstructive breast procedures.
    • Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos, and references from the book on a variety of devices.

  • Clinical Neuroradiology
    by Barkhof
    La comanda in aproximativ 4 saptamani
    5,60000lei 5120.00 lei


    This superbly illustrated 3 volume textbook, endorsed by the European Society of Neuroradiology, explains in detail the clinical importance of neuroradiology in complementing history taking and physical examination during the workup of patients suspected of having neurological, neurosurgical, or psychiatric disorders. The role of imaging of the brain and spinal cord is described across the full range of relevant conditions, including, cerebrovascular diseases, trauma, CSF disorders, developmental malformations, inflammatory diseases, epilepsy, tumors and tumor-like conditions, neurodegenerative diseases, metabolic conditions and neuromuscular disorders. The structured approach to imaging and image analysis will ensure that the book is an invaluable resource for neuroradiologists in training and clinicians alike. Starting from the clinical indication, suggestions for imaging protocols are provided and checklists of common findings and aspects key to interpretation are presented. The book is published within the SpringerReference program, which combines thorough coverage with access to living editions constantly updated via a dynamic peer-review process.

    Sections in the Textbook:

    Indications, Technique, and Anatomy: Tarek A. Yousry,

    Cerebrovascular Diseases: Rüdiger von Kummer,

    Trauma: Johan Van Goethem,

    CSF Disorders: Charles Romanowski,

    Infectious Brain Disease: Majda M. Thurnher,

    Inflammatory and Autoimmune Brain Diseases: Alex Rovira,

    Epilepsy: Nuria Bargalló,

    Tumor and Tumorlike Conditions: Hans Rolf Jäger,

    Dementia and Neurodegenerative Diseases: Sven Haller,

    Toxic and Acquired Metabolic Conditions: Andrea Falini,

    Pediatric Neuroradiology: Andrea Rossi,

    Spine and Spinal Cord: Mario Muto,

    Peripheral Nervous System and Neuromuscular Disease: Mike Wattjes


  • 5,60000lei 4500.00 lei

    This comprehensive book presents the latest information on all aspects of the aging skin, including a broad spectrum of the relevant basic science, malignant and non-malignant age-associated diseases and conditions, techniques and methods, toxicological and safety considerations in the elderly, psychological and social issues, ethnicity and gender differences and marketing to the aged. Since the first edition the book has been extensively updated and revised, with the inclusion of many additional chapters that describe the most recent advances in scientific, medical and technical understanding of the aging phenomenon. There is, for example, extended coverage of physiology, description of novel bioengineering methods and tools, detailed consideration of developments in genomics research, and information on new ingredients and products. Textbook of Aging Skin is written by global experts and thought leaders and is intended to serve as the single and complete reference on the subject. It will be of value for dermatologists, gerontologists, toxicologists, biologists and a range of other professionals.

  • The Aneurysm Casebook
    by Henkes
    La comanda in aproximativ 4 saptamani
    5,00000lei 4500.00 lei


    This encyclopedic reference book on the treatment of intracranial aneurysms offers a case-based approach to the subject that has the benefit of fully reflecting the highly individual technical and clinical challenges encountered in aneurysm patients. The book is structured by aneurysm location, ensuring ease of use. Readers will find solutions for most clinical situations that they may encounter. Different treatment strategies are described, highlighting their respective pros and cons in particular circumstances. The coverage encompasses both basic techniques, such as coil occlusion and parent vessel occlusion, and the latest developments, including extra- and intrasaccular flow diversion, intrasaccular flow disruption, bifurcation stenting, and hybrid procedures combining microsurgical and endovascular elements. Potential procedural complications are identified, and bail-out strategies to anticipate, avoid, and solve major issues are described. The authors are all respected experts in the field, and the book will be of value to vascular and endovascular neurosurgeons, interventional neuroradiologists and neurologists, stroke neurologists, and other practitioners at all levels of experience.

  • Textbook of Pediatric Neurosurgery
    La comanda in aproximativ 4 saptamani
    5,33700lei 4420.00 lei


    This book documents the state of the art in pediatric neurosurgery with the intention of providing a comprehensive guide to the management of the full range of pediatric neurosurgical disorders that will aid in the delivery of optimal care. Detailed practical instruction, taking into account recent advances, is provided on the neurosurgical treatment of congenital brain malformations, cerebrovascular diseases, head injuries and spinal trauma, infections, functional disorders, congenital and developmental spinal disorders, and brain and spinal tumors. Pearls and pitfalls are highlighted, and attention drawn to the most useful tips and tricks. Information is also included on relevant related topics, including the principles of neuroimaging, the physiological responses of newborns, infants, and children to neurosurgical trauma, preoperative evaluation, anesthesiology and intensive care, and other forms of therapy. The authors are renowned experts in the field, and the text is supported by a wealth of high-quality images. Handbook of Pediatric Neurosurgery will be of value for neurosurgeons of all levels of experience, as well as for pediatricians, neuroradiologists, neuropathologists, and neuro-oncologists.

  • Pediatric Hydrocephalus
    by Cinalli
    La comanda in aproximativ 4 saptamani
    4,77500lei 4220.00 lei


    Since the first edition of this book, the impressive development of neuroendoscopy has dramatically changed the surgical approach to hydrocephalus, the main pathology pediatric neurosurgeons worldwide have to deal with. This revised and updated second edition, written by worldwide leaders in the field, fully reflects this progress: not only existing chapters have been  reviewed whenever required, but new ones have been added   thus taking into consideration every aspect of hydrocephalus, even when associated with the rarest pathologies. The general part include now more data on history, biomechanics, circulation and molecular basis. Special consideration for fetal surgery has been added, whereas the section on neonatal hydrocephalus has been further developed. Section 4, on the different pathologies associated with hydrocephalus, has been significantly expanded. and is now amazingly detailed, as well as the section on shunt treatment. Infections are now dealt with in two different chapters, and special attention to shunt complications (the nightmare of every Pediatric Neurosurgeon.) is paid in five different chapters. A very complete overview of the endoscopic treatment, that will surely draw the reader’s attention  thanks to the wonderful full color images, is also included. Written by acknowledged experts in the field, this title is an indispensable tool for all those facing this pathology in their daily practice.

  • 4,77500lei 4100.00 lei


    The seventh edition of Pediatric Nephrology, now in three volumes, has been extensively updated and also contains much new material. Its organization flows logically from renal physiology to clinical evaluation. Discussion of the development of kidney structure and function is followed by sections on basic and translational research and on clinical methods, including laboratory tests, diagnostic imaging, and renal pathology. Comprehensive chapters then cover each of the childhood kidney diseases, grouped according to major disease categories. All of these chapters make new genetic information easily understandable for the practitioner and use many algorithms and diagrams to describe appropriate clinical evaluation of symptoms, differential diagnosis, specific diagnostics and currently available therapies. This book, global in perspective, serves as a superb reference and is an invaluable asset during clinical encounters with children having all forms of kidney disease.

  • Neurovascular Imaging
    by Saba
    La comanda in aproximativ 4 saptamani
    4,20000lei 3730.00 lei


    Vascular Neurology, Vascular Neurosurgery and Interventional Neuroradiology are independent fields with dedicated Training Programs. Neuroimaging, and in particular what we call "Neurovascular Imaging" is a unifying factor which can be considered the intersection of these three medical specialties. With this book we aim to cover thoroughly the imaging techniques, potentialities, and present and future applications as applied to all the vascular diseases of the central nervous system from the imaging point of view. This book will comprise eight main sections: (1) The Basics, (2) Arteries of the Head and Neck (3) The basics of Intracranial Arteries (4) Diseases of the vessels (5) Stroke Imaging (6) Veins Imaging (7) Spine Imaging (8) Pediatrics.

  • Principles of Diabetes Mellitus
    La comanda in aproximativ 4 saptamani
    3650.00 lei

    • Revises and expands on classic earlier editions, providing a comprehensive text on diabetes mellitus
    • Covers all major topics including glucose metabolism, diagnosis and epidemiology, genetics, management and prevention
    • Provides a global perspective on diabetes mellitus, diabetic syndromes and related disorders
    • Delivers expertise in diabetes research and treatment, edited by a leading figure in the field

    About this Reference Work

    The third edition of this important work is a timely update to the comprehensive textbook first published in 2002 and reissued in a second edition in 2010. The past few years have witnessed major developments in our understanding of diabetes and in therapeutic approaches to this disease and its numerous complications. Thus, all chapters have been significantly revised and updated with current evidence and best practices, and four brand new chapters are included, discussing the potential role of vitamin D in the pathogenesis of diabetes, peculiarities of diabetes in the elderly, oral manifestations of diabetes, and the current state of bariatric surgery.

    Written by an international group of experts and carefully edited by a leading authority on the subject, Principles of Diabetes Mellitus, Third Edition is an invaluable resource for researchers and physicians of all specialties, as well as medical students and investigators of all aspects of diabetes, who deal with an illness that has reached epidemic proportions.

  • Tips and Tricks: Masterclass of Intramedullary Nailing
    La comanda in aproximativ 4 saptamani
    3560.00 lei

    This is a step-by-step guide to common orthopedic procedures, highlighting pitfalls and offer possible solutions. Each intervention is supported by X-ray evidence. It describes minimal access approaches to allow surgeons to perform intramedullary nailing of the femur, tibia and humerus. The techniques covered are well illustrated with radiographs and drawings, and provide practical guidance on surgical techniques. This is a unique reference book explaining multiple variations of intramedullary nailing operative techniques in a detailed step-by-step manner. Includes guidelines on positioning of the patient, finding the correct entry point positioning of the guidewire, technique of reaming, and insertion of nail into an appropriate site in the bone to avoid subsequent complications, morbidity and mortality of the patient. Encompasses a broad range of surgeries including fixation techniques of long bones as well as hand fractures. Guidelines are based on a course accredited by the Royal College of Surgeons, England, UK, which is run by the author himself.

  • Martindale: The Complete Drugs Reference
    La comanda in aproximativ 4 saptamani
    3440.00 lei



    – Breadth: No other source of drug information contains the wide range of content or the same level of detail, making it the ideal first-line reference work as well as a trusted source of information for detailed and complex drug enquiries


    – Global coverage: The leading resource in terms of international content, including information from over 43 countries


    – Objectivity: Respected for the accuracy of content, appraised and authored by experts with editorial independence from the pharmaceutical industry. Based on information from published papers, regulatory sources and guidelines, with extensive referencing


    – International adoption: Recognised, trusted and adopted worldwide Martindale is depended upon by healthcare professionals throughout the world for its reliable and comprehensive information on international drugs and medicines. It is widely recognised for its unbiased and authoritative nature, as well as its unprecedented international coverage, including information from 43 countries and regions.


    A team of experts use the most clinically relevant and reliable information, giving healthcare professionals a complete resource for reference on drugs and medicines.


    Martindale contains proprietary drug information on preparations available worldwide, and remains a critical tool for identification of the local equivalent of a prescribed preparation and for assessing what alternatives might be suitable when needed.

    Martindale: The Complete Drug Reference provides unbiased and evaluated information on drugs and medicines in use around the world. It is prepared by an experienced team of pharmacists and life scientists who use their professional expertise to select the most clinically relevant and appropriate information from reliable published sources, to provide an unbiased and evaluated digest of the literature.


    Over 6,300 drug monographs
    Over 185,000 preparations
    Over 54,000 reference citations
    Over 20,000 manufacturers and distributors
    Proprietary preparations from 43 countries and regions
    Nearly 700 treatment reviews, with references from the published literature
    Enables identification of medicines, the local equivalent and the manufacturer
    Includes herbals, diagnostic agents, radiopharmaceuticals, pharmaceutical excipients, toxins, and poisons as well as drugs and medicines

    Changes to this new edition:

    More than 130 new monographs including:

    Lumacaftor: a cystic fibrosis transmembrane conductance regulator (CFTR) protein corrector

    Pitolisant: a central stimulant used in the treatment of narcolepsy

    Rolapitant: a neurokinin-1 receptor antagonist that is used for the prevention of nausea and vomiting associated with cancer chemotherapy

    Umeclidinium Bromide: a quaternary ammonium antimuscarinic used as a bronchodilator in the treatment of reversible airways obstruction

    New Hepatitis C treatment table and drugs including ledipasvir, ombitasvir, paritaprevir, and dasabuvir

    Coverage of proprietary preparations in 43 countries including Australia, China, UK, and USA, revised and updated



  • 3,60000lei 3300.00 lei



    Dramatically updated to reflect recent advances in the basic and clinical neurosciences, Youmans and Winn Neurological Surgery, 7th Edition remains your reference of choice for authoritative guidance on surgery of the nervous system. Four comprehensive volumes thoroughly cover all you need to know about functional and restorative neurosurgery, (FRN)/deep brain stimulation (DBS), stem cell biology, radiological and nuclear imaging, and neuro-oncology, as well as minimally-invasive surgeries in spine and peripheral nerve surgery, endoscopic and other approaches for cranial procedures and cerebrovascular diseases. Seventy new chapters, an expanded video library, and revised content throughout help you master new procedures, new technologies, and essential anatomic knowledge. This unparalleled multimedia resource covers the entire specialty with the unquestioned guidance you’ve come to expect from the "Bible of neurological surgery."


    Each clinical section contains chapters on technology specific for that particular clinical area.

    Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

    New To This Edition:

    An expanded video library includes more than 300 videos with audio commentary, including 36 stunning anatomy videosmore than 100 videos demonstrating intra-operative procedures, and lectures that clarify key concepts.

    70 new chapters provide cutting-edge information on Surgical Anatomy of the Skull Base; Coagulation for the Neurosurgeon; Brain Retraction; Optogenetics and Clarity; Ablative Procedures for Parkinson's Disease; Nerve Transfers; Indications and Techniques of Revision Spine Surgery; Traumatic Brain Injury: Proteomic Biomarkers; Acute Surgical and Endovascular Management of Ischemic/Hemorrhagic Stroke; and many more.

    Thorough coverage of new techniques and approaches, including minimally-invasive surgeries in spine and peripheral nerve surgery, endoscopic approaches for cranial procedures, and stereotactic and robot-assisted surgery.

    Each section contains a new chapter providing an expert overview from experienced Section Editors, including a report on ongoing controversies within that subspecialty.

    Updates include expanded coverage of the basic science of CNS infections, increased content on radiology and anatomy, new chapters on various aspects of patient safety, new coverage of anti-coagulation therapy in the elderly, new skull base approaches, an overview of spinal biomechanics for all forms of spinal instrumentation, detailed coverage of intraoperative navigation, improved methods of tumor resection and the role of whole-brain radiotherapy, and much more.

    Reorganized content facilitates ease of navigation, so you can find what you need quickly.

    Table Of Contents:

    VOLUME 1

    Introduction to Neurological Surgery

    PART 1


    Chapter 1 Historical Overview of Neurosurgery

    James Tait Goodrich and Eugene S. Flamm

    PART 2

    Basic Science

    Chapter 2 Surgical Anatomy of the

    Hung Tzu Wen, Albert L. Rhoton Jr, and
    Antônio C. M. Mussi

    Chapter 3 Molecular Biology Primer
    for Neurosurgeons

    Kevin Y. Miyashiro and James Eberwine

    Chapter 4 Neuroembryology

    Harvey B. Sarnat, Laura Flores-Sarnat, and
    Joseph D. Pinter

    Chapter 5 Stem Cell Biology
    in the Central Nervous

    Philip J. Horner and Samuel E. Nutt

    Chapter 6 Neurons and Neuroglia

    Bruce D. Trapp and Karl Herrup

    Chapter 7 Cellular Mechanisms
    of Brain Energy

    Albert Gjedde and Pierre Magistretti

    Chapter 8 Blood-Brain Barrier

    Shahid M. Nimjee, Gerald A. Grant,
    H. Richard Winn, and Damir Janigro

    Chapter 9 Cerebral Edema

    Robert J. Weil and Edward H. Oldfield

    Chapter 10 Physiology of the Cerebrospinal Fluid and Intracranial Pressure

    Anthony Marmarou and Andrew Beaumont

    Chapter 11 Neurosurgical Epidemiology and Outcomes Assessment

    Hugh Garton, Frederick G. Barker II, and
    Stephen J. Haines

    parT 3

    Approach To The Patient

    Chapter 12 Altered Consciousness

    Nicholas D. Schiff

    Chapter 13 Neuroophthalmology

    Timothy J. Martin and James J. Corbett

    Chapter 14 Neurotology

    P. Ashley Wackym and Christina L. Runge-Samuelson

    Chapter 15 Neurourology

    Brett D. Lebed and Eric S. Rovner

    Chapter 16 Neuropsychological Testing

    Jordan Grafman

    parT 4

    Radiologic Fundamen



  • 4,46200lei 3150.00 lei


    About this book

          This book documents the state of the art in pediatric neurosurgery with the intention of providing a comprehensive guide to the management of the full range of pediatric neurosurgical disorders that will aid in the delivery of optimal care. Detailed practical instruction, taking into account recent advances, is provided on the neurosurgical treatment of congenital brain malformations, cerebrovascular diseases, head injuries and spinal trauma, infections, functional disorders, congenital and developmental spinal disorders, and brain and spinal tumors. Pearls and pitfalls are highlighted, and attention drawn to the most useful tips and tricks.

          Information is also included on relevant related topics, including the principles of neuroimaging, the physiological responses of newborns, infants, and children to neurosurgical trauma, preoperative evaluation, anesthesiology and intensive care, and other forms of therapy. The authors are renowned experts in the field, and the text is supported by a wealth of high-quality images. Handbook of Pediatric Neurosurgery will be of value for neurosurgeons of all levels of experience, as well as for pediatricians, neuroradiologists, neuropathologists, and neuro-oncologists.


    Table of Contents:


    Pages i-xl


    Pages 1-1

    Development of the Central Nervous System

    Martin Catala

    Pages 3-77

    Neurologic Development and Objective Neurological Examination of the Infant and the Child

    Elvio Della Giustina

    Pages 79-108

    Principles of Neuroimaging

    Charles Raybaud

    Pages 109-131

    Physiological Responses of the Newborn, Infant, and Child to Neurosurgical Trauma

    Anthony Figaji

    Pages 133-151

    Basic Preoperative Evaluation, Anesthesiological, and Intensive Care Management in the Pediatric Patients

    Tomohiro Yamamoto, Ehrenfried Schindler

    Pages 153-172

    Pediatric Chemotherapy

    Didier Frappaz, Cécile Faure-Conter

    Pages 173-183

    Pediatric Radiotherapy: Background and Current Paradigms

    Ryan P. Lee, Christopher L. Tinkle, John T. Lucas Jr, Thomas E. Merchant, Frederick A. Boop

    Pages 185-208

    Pediatric Radiotherapy: Surgical Considerations, Sequelae, and Future Directions

    Ryan P. Lee, John T. Lucas Jr, Christopher L. Tinkle, Thomas E. Merchant, Frederick A. Boop

    Pages 209-218

    Congenital Brain Malformation and Acquired Disorders

    Pages 219-219

    Encephalocele, Meningocele, and Dermal Sinus

    Sandip Chatterjee, Kaushik Sil, L. S. Harishchandra

    Pages 221-241

    Chiari Malformations Types II, III, IV, and V

    Luca Massimi, Massimo Caldarelli, Concezio Di Rocco

    Pages 243-275

    Craniopagus Twins

    James Tait Goodrich, Andrew Joshua Kobets, Kamilah Dowling, Oren Tepper

    Pages 277-295

    Hydrocephalus: Generalities and Clinical Presentations

    Concezio Di Rocco, Paolo Frassanito

    Pages 297-332

    Neuroimaging in Pediatric Hydrocephalus

    Charles Raybaud

    Pages 333-423

    Fetal Hydrocephalus and Its Treatment In Utero

    Sergio Cavalheiro, Antonio Fernandes Moron, Marcos Devanir Silva da Costa, Patricia Alessandra Dastoli, Jardel Mendonça Nicacio, Italo Capraro Suriano

    Pages 425-442

    Posthemorrhagic Hydrocephalus

    Juan F. Martínez-Lage, Antonio L. López-Guerrero, María-José Almagro

    Pages 443-461

    Postinfective Hydrocephalus

    Deepak Gupta, Kanwaljeet Garg

    Pages 463-485

    Multiloculated Hydrocephalus

    Graciela Zuccaro, Javier González Ramos

    Pages 487-500

    Aqueductal Stenosis and Hydrocephalus

    Paolo Frassanito, Burcu Goker, Concezio Di Rocco

    Pages 501-519

    X-Linked Hydrocephalus

    Mami Yamasaki, Yonehiro Kanemura

    Pages 521-531

    Hydrocephalus Associated with Myelomeningocele

    Radovan M. Mijalcic

    Pages 533-547

    Hydrocephalus Associated with Tumors

    Mohamed A. El Beltagy

    Pages 549-559

    Medical Treatment of Hydrocephalus

    Burcu Goker, Gianpiero Tamburrini

    Pages 561-566

    Surgical Treatment of Hydrocephalus Based on CSF Shunt Devices

    Paolo Frassanito, Gianpiero Tamburrini, Concezio Di Rocco

    Pages 567-574

    In-Depth View: Functional Characteristics of CSF Shunt Devices (Pros and Cons)

    Alfred Aschoff

    Pages 575-604

    How to Perform a V-P CSF Shunt?

    Didier Scavarda, Maurice Choux

    Pages 605-617

    How to Perform a Ventriculo-atrial CSF Shunt

    Paolo Frassanito, Federico Bianchi, Gianpiero Tamburrini

    Pages 619-625

    In-Depth View: How to Perform a Lumboperitoneal CSF Shunt

    Soumya Mukherjee, Paul D. Chumas

    Pages 627-640

    How to Perform a Ventriculopleural Shunt

    Hamilton Matushita

    Pages 641-646

    How to Perform a Ventriculo-subgaleal CSF Shunt

    Paolo Frassanito, Simone Peraio, Luca Massimi

    Pages 647-653

    How to Perform a Ventriculo-gallbladder CSF Shunt

    Hamilton Matushita

    Pages 655-659

    External CSF Shunts

    Mario Garcia-Conde, Julio Plata-Bello, Liberto Brage-Martin, Lucia Martin-Viota

    Pages 661-680

    Complications Related to the Treatment of Hydrocephalus with Extrathecal Cerebrospinal  Fluid Shunts

    Carmine Mottolese, Pierre-Aurélien Beuriat, Alexandru Szathmari, Federico Di Rocco

    Pages 681-704

    Late Complications of Shunts

    Paolo Frassanito, Simone Peraio, Concezio Di Rocco

    Pages 705-727

    Endoscopic Treatment of Hydrocephalus Through Endoscopic Third Ventriculostomy

    Gianpiero Tamburrini

    Pages 729-754

    Endoscopic Third Ventriculostomy: Technique

    Gianpiero Tamburrini

    Pages 755-765

    Surgical Technique of Endoscopic Choroid Plexus Coagulation

    Waleed A. Azab

    Pages 767-771

    Complications of Endoscopic Third Ventriculostomy

    Roberta Rehder, Alan R. Cohen

    Pages 773-788

    Intracranial Congenital Arachnoid Cysts

    Luca Massimi, Massimo Caldarelli, Concezio Di Rocco

    Pages 789-829

    Dandy–Walker Malformations/Variants

    Pietro Spennato, Daniele Cascone, Giuliana Di Martino, Giuseppe Mirone, Claudio Ruggiero, Giuseppe Cinalli

    Pages 831-856

    Cortical Dysplasia

    Helio Rubens Machado, Marcelo Volpon Santos

    Pages 857-882

    Neurocutaneous Disorders

    Martino Ruggieri, Andrea D. Praticò, Agata Polizzi

    Pages 883-917

    Neurofibromatosis Type 1

    Sergey Gorelyshev, Natalia Serova, Nadezhda Mazerkina, Endzhe Valiakhmetova

    Pages 919-963

    Neurofibromatosis 2

    Sergey Gorelyshev, Endzhe Valiakhmetova, Igor Pronin

    Pages 965-988

    Sturge-Weber Syndrome

    Gianpiero Tamburrini, M. Mohsen Amen, Concezio Di Rocco

    Pages 989-998

    Tuberous Sclerosis

    Federica Novegno, Concezio Di Rocco

    Pages 999-1032

    Von Hippel-Lindau Disease

    Mario Giordano, Cinta Arraez, Concezio Di Rocco

    Pages 1033-1047


    Luca Massimi, Concezio Di Rocco

    Pages 1049-1080

    Congenital Brain Malformation and Acquired Disorders

    Cerebrocutaneous Melanosis

    Wolf Lüdemann, Concezio Di Rocco

    Pages 1081-1088

    Encephalocraniocutaneous Lipomatosis

    Luca D’Angelo

    Pages 1089-1095

    Cerebrovascular Diseases

    Pages 1097-1097

    Vein of Galen Aneurysmal Malformations

    Sergey Gorelyshev, Sergey Jakovlev, Adam Adaev

    Pages 1099-1134

    Pediatric Arterivenous Malformations

    Abilash Haridas, Reza Dashti, Tahaamin Shokuhfar, Ali Shaibani

    Pages 1135-1168


    Luca Massimi, Souvik Kar, Mario Giordano, Helmut Bertalanffy

    Pages 1169-1201

    Pediatric Intracranial Aneurysms

    Gao Zeng, Lidan Jiang

    Pages 1203-1263

    Moyamoya Disease

    Kyu Won Shim, Eun Kyung Park, Joong Uhn Choi, Dong Seok Kim

    Pages 1265-1281

    Head Injuries

    Pages 1283-1283

    Birth-Related Head Traumas

    Llewellyn C. Padayachy, A. Graham Fieggen

    Pages 1285-1296

    Accidental Head Traumas

    Jessica S. Wallisch, Michael J. Bell, Kimberly Foster

    Pages 1297-1319

    Neurosurgical Aspects of Nonaccidental Injury in Children

    Johannes Nicholaas Enslin, Anthony Figaji

    Pages 1321-1336

    Decompressive Craniectomy in Pediatric Traumatic Brain Injury

    Adam M. H. Young, Peter J. A. Hutchinson

    Pages 1337-1348

    Pediatric Traumatic Brain Injury: Outcomes and Rehabilitation

    Leigh E. Schrieff-Elson, Kevin G. F. Thomas, Ursula K. Rohlwink

    Pages 1349-1369

    Congenital Malformations of the Skull and Its Coverings

    Pages 1371-1371

    Craniosynostosis: Genetic Basis, Genes, Chromosomes, and Resulting Syndromes

    Wanda Lattanzi

    Pages 1373-1391

    Craniosynostoses: Lessons Learned from Animal Models

    Emilie Dambroise, Maxence Cornille, Davide Komla-Ebri, Nabil Kaci, Martin Biosse-Duplan, Federico Di Rocco et al.

    Pages 1393-1407

    Sagittal Synostoses

    Federico Di Rocco

    Pages 1409-1423

    Unilateral Coronal Craniosynostosis

    Luca Massimi, Concezio Di Rocco

    Pages 1425-1460

    Metopic Suture Synostoses

    Saffet Mutluer

    Pages 1461-1478

    Lambdoid Synostoses

    Gianpiero Tamburrini, M. Mohsen Amen, Concezio Di Rocco

    Pages 1479-1489

    Nonsyndromic Plurisutural Synostoses (Oxycephaly, Mercedes Benz Pattern Synostosis)

    Kazuaki Shimoji, Masakazu Miyajima, Hajime Arai

    Pages 1491-1510

    Syndromic Craniosynostosis

    José Hinojosa Mena-Bernal

    Pages 1511-1540

    Secondary Craniosynostoses

    Marek Mandera

    Pages 1541-1548

    ICP in Craniosynostosis

    Gianpiero Tamburrini

    Pages 1549-1555

    Management of Craniosynostosis: Evaluation of Results

    Martina Messing-Jünger

    Pages 1557-1566

    Blood-Sparing Techniques and the Perioperative Management of Blood Losses

    Federica Tosi, Angela Pusateri, Sonia Sensi, Rossella Garra

    Pages 1567-1576

    Osteogenic Distraction

    Leonid Satanin, Niina Salokorpi, Vitaliy Roginskiy, Alexander L. Ivanov, Willy Serlo

    Pages 1577-1592

    Endoscopic Treatment of Craniosynostosis

    José Hinojosa Mena-Bernal

    Pages 1593-1609

    Spring-Assisted Distraction: Principles and Techniques

    Noor Ul Owase Jeelani

    Pages 1611-1622

    Bone Splitting and Materials

    James Tait Goodrich, Kamilah Dowling, Oren Tepper

    Pages 1623-1642

    Neuropsychological Evaluation of Single Suture Craniosynostosis (SSC)

    Daniela Chieffo

    Pages 1643-1656

    Craniosynostosis: Repercussions on Schooling, Inclusive Education, and Siblings

    Séverine Colinet, Philippe Bonnet, Federico Di Rocco

    Pages 1657-1661

    Deformational Posterior Plagiocephaly

    Luca Massimi

    Pages 1663-1692

    Scalp Agenesis

    Luca D’Angelo

    Pages 1693-1698


    Pages 1699-1699

    Meningitis: Neurosurgical Implications

    Kristian Aquilina

    Pages 1701-1717


    Annie I. Drapeau, Lance S. Governale

    Pages 1719-1733

    Empyemas and Brain Abscesses

    Philipp R. Aldana, Kelly Gassie

    Pages 1735-1749

    Pediatric Tuberculosis and Parasitic and Fungal Infections

    Michael D. White, Michael M. McDowell, Taylor J. Abel

    Pages 1751-1771


    Pages 1773-1773

    Genetic Basis and Classification of Cerebral Neoplasms

    Vijay Ramaswamy, Carolina Nör

    Pages 1775-1791

    Familial Syndromes

    Isabelle Ferry, Saira Alli, James T. Rutka

    Pages 1793-1834

    Infantile and Congenital Tumor

    Federico Bianchi, Gianpiero Tamburrini

    Pages 1835-1851

    Cerebral Gliomas

    Justin Cohen, Sergui Bannykh, Joshua Breunig, Moise Danielpour

    Pages 1853-1875

    Thalamic Gliomas

    Dhruve S. Jeevan, James T. Rutka

    Pages 1877-1890

    Optic Pathway Gliomas

    Eveline Teresa Hidalgo, Cordelia Orillac, Jeffrey H. Wisoff

    Pages 1891-1907

    Pituitary Adenomas

    Davis G. Taylor, Panagiotis Mastorakos, Gabriella M. Paisan, I. Jonathan Pomeraniec, Maria-Beatriz S. Lopes, John A. Jane Jr.

    Pages 1909-1920


    Jean-Pierre Farmer, Todd Hankinson, Roy Dudley

    Pages 1921-1940

    Pineal Region Tumors

    Nir Shimony, Asim F. Choudhri, John T. Lucas Jr., Paul Klimo Jr.

    Pages 1941-1956


    Brainstem Tumors

    Peter A. Chiarelli, Jason K. Chu, Mark D. Krieger

    Pages 1957-1983

    Cerebellar Astrocytomas

    Travis J. Atchley, Jeffrey P. Blount

    Pages 1985-1995


    A. S. Guerreiro Stucklin, C. M. Kuzan-Fischer, Michael D. Taylor

    Pages 1997-2016


    John S. Myseros

    Pages 2017-2037

    Pediatric Meningioma

    Lissa C. Baird, Nathan R. Selden

    Pages 2039-2051


    Douglas R. Taylor, Jorge A. Lee Diaz, Frederick A. Boop

    Pages 2053-2070

    Choroid Plexus Tumors

    Kristian Aquilina

    Pages 2071-2093

    Skull Base Tumors

    Mark Calayag, Reid Hoshide, Joanna Kemp, Michael Levy

    Pages 2095-2105

    Skull Tumors and Scalp Lesions

    Timothy Beutler, Beth Currado, Zulma Tovar-Spinoza

    Pages 2107-2119

    Functional Disorders

    Pages 2121-2121

    What Is Epilepsy?

    Berge Minassian, Evan Lewis, Robyn Whitney

    Pages 2123-2141

    Medical Intractable Epilepsy: Preoperative Evaluation

    Cristina Y. Go

    Pages 2143-2154

    Catastrophic Epilepsy and Hemispherotomy

    Brian J. Dlouhy, Matthew D. Smyth

    Pages 2155-2167

    Temporal Lobe Epilepsy Surgery

    Sandi Lam, Howard L Weiner

    Pages 2169-2185

    Extratemporal Lobe Epilepsy in Children: Localization and Outcomes After Surgery

    James T. Rutka, Laura-Nanna Lohkamp, Brian Hanak

    Pages 2187-2201

    Palliative Surgical Techniques (VNS, Callosotomy)

    James E. Baumgartner, Fatima Q. Ajmal

    Pages 2203-2219


    Benjamin Davidson, George M. Ibrahim, James T. Rutka

    Pages 2221-2240


    Michael M. McDowell, Taylor J. Abel

    Pages 2241-2254

    Movement Disorders

    Vamsidhar Chavakula, Scellig S. D. Stone

    Pages 2255-2271

    Congenital and Developmental Spinal Disorders

    Pages 2273-2273

    Genetic Basis of Neural Tube Defects

    Andrew J. Copp, Philip Stanier, Nicholas D. E. Greene

    Pages 2275-2294

    Classification of Spinal Dysraphic Malformations According to Embryogenesis: Gastrulation Defects and Split Cord Malformation

    Dachling Pang, Yong Jin Hou, Sui T. Wong

    Pages 2295-2340

    Open Neural Tube Defects

    Jetan H. Badhiwala, Farshad Nassiri, Abhaya V. Kulkarni

    Pages 2341-2363

    Limited Dorsal Spinal Nondisjunctional Disorders: Limited Dorsal Myeloschisis, Congenital Spinal Dermal Sinus Tract, and Mixed Lesions

    Sui T. Wong, Amanda Kan, Dachling Pang

    Pages 2365-2422

    Secondary Neurulation Defects-1: Thickened Filum Terminale, Retained Medullary Cord

    Dachling Pang, Sangjoon Chong, Kyu-Chang Wang

    Pages 2423-2437

    Secondary Neurulation Defects-2: Terminal Myelocystocoele: Surgical Observations, Laboratory Findings, and Theory of Embryogenesis

    Dachling Pang, Ji Yeoun Lee, Kyu-Chang Wang

    Pages 2439-2480

    Surgical Management of Complex Spinal Cord Lipomas: How, Why, and When to Operate

    Dachling Pang

    Pages 2481-2532

    Antenatal Management of Spinal Dysraphism-2: Antenatal Surgery of Myelomeningocele

    Sergio Cavalheiro, Antonio Fernandes Moron, Mauricio Mendes Barbosa, Italo Capraro Suriano, Hérbene Jose Milani, Marcos Devanir Silva da Costa et al.

    Pages 2533-2555

    Caudal Agenesis and Associated Spinal Cord Malformations

    Ji Yeoun Lee, Dachling Pang, Kyu-Chang Wang

    Pages 2557-2575

    Spinal Cord Arteriovenous Shunts in the Pediatric Population

    Arturo Consoli, Georges Rodesch

    Pages 2577-2598

    Intraspinal Cysts Including Syringomyelia Unrelated to Chiari I Ma lformation

    Zubair Tahir, Dominic N. P. Thompson

    Pages 2599-2621

    Scoliosis and Other Congenital Vertebral Anomalies

    Mari L. Groves, Andrew C. Vivas, Amer F. Samdani

    Pages 2623-2633

    Craniovertebral Junction Disorders

    Pages 2635-2635

    Embryology, Classification, and Surgical Management of Bony Malformations of the Craniovertebral Junction

    Dachling Pang

    Pages 2637-2708

    Chiari I Malformation and Associated Syringomyelia

    Dominic N. P. Thompson

    Pages 2709-2732

    Anterior Surgical Approaches to the Craniovertebral Junction and Upper Cervical Spine

    Dominic N. P. Thompson

    Pages 2733-2754

    Special Considerations for Surgical Fusion of the Occiput and Cervical Spine

    Kyle G. Halvorson, Douglas L. Brockmeyer

    Pages 2755-2769

    Spine and Spinal Cord Neoplasms

    Pages 2771-2771

    Intramedullary Tumors

    Adam Ammar, Neil Haranhalli, Phillip Cezayirli, Andrew Joshua Kobets, Rick Abbott

    Pages 2773-2788

    Intradural Extramedullary Spinal Tumors

    Atul Goel

    Pages 2789-2809

    Vertebral Tumours

    Dominic N. P. Thompson

    Pages 2811-2833

    Spinal Trauma

    Pages 2835-2835

    Spine and Spinal Cord Injuries in Children: General Aspects Including Pure Ligamentous Injuries in Children

    Vijay M. Ravindra, Douglas L. Brockmeyer

    Pages 2837-2852

    Spinal Cord Injury Without Radiographic Abnormality (SCIWORA) in Children

    Dachling Pang, Sebastian Eibach

    Pages 2853-2882

    Traumatic Atlanto-Occipital Dislocation in Children

    Sui T. Wong, Dachling Pang

    Pages 2883-2905

    Atlantoaxial Rotatory Fixation (AARF)

    Dachling Pang

    Pages 2907-2939

    Infectious Diseases of the Spine

    Pages 2941-2941

    Tuberculosis of the Spine

    Sandip Chatterjee

    Pages 2943-2957

    Pediatric (Nontuberculous) Spinal Infections

    Chandrashekhar E. Deopujari, Chandan B. Mohanty

    Pages 2959-2974

    Pediatric Disc Disease

    Mark S. Dias, Elias Rizk

    Pages 2975-2989

    Intraoperative Neurophysiology Monitoring

    Pages 2991-2991

    Intraoperative Neurophysiology During Intracranial Surgery in Children

    Francesco Sala, Angela Coppola, Yong Jin Hou, Dachling Pang

    Pages 2993-3020

    Intraoperative Neurophysiology During Spine and Spinal Cord Surgery in Children

    Francesco Sala, Yong Jin Hou

    Pages 3021-3044

    Back Matter

    Pages 3045-3077


  • 3,93200lei 3146.00 lei


    This new edition builds upon the foundation of the first and second editions of the handbook, volumes separated by a decade of experience in the field, in a format that is both comprehensive and fluid. The combination of print and electronic versions will promote more rapid up-dating of chapters as new information appears. The Third Edition opens with general principles. The broad body of the volume encompasses diseases of the elderly and physiologic changes by system, as well as geriatric syndromes, perioperative management, and transitions of care into post-acute settings. The large concluding section is comprised of specialty-specific results of surgery in the elderly and suggested modifications recommended by experienced surgeons. Principles and Practice of Geriatric Surgery provides a comprehensive account that will allow all providers of healthcare to the elderly understand the issues involved in choosing surgery as a treatment option for their patients.

  • 3,75500lei 3100.00 lei

    The ultimate guide to aesthetic surgery from world famous aesthetic surgeon Foad Nahai

    The Art of Aesthetic Surgery, Principles and Techniques, Third Edition by internationally revered aesthetic surgeon Foad Nahai, five distinguished co-editors, and more than 100 new contributors is an encyclopedic, three-volume masterwork. Considered the quintessential resource on cosmetic surgery since its inception, the new edition features an e-book and access to online videos for the first time. The updated text and videos reflect significant and numerous exciting developments in aesthetic medicine and surgery.

    An impressive group of renowned global experts contribute valuable insights, pearls, and considerable expertise. Twenty new chapters feature a wealth of diverse state-of-the-art topics, while other chapters have been updated and greatly expanded. New areas of focus include practice management, volume enhancement in periorbital and facial rejuvenation, minimally invasive neck techniques, and body contouring procedures such as umbilicoplasty. Patient safety is prominent, with a major chapter on safety considerations in aesthetic surgery, as well as discussion of complications in different anatomic regions.

    Key Highlights

    ·         A state-of-the-art review of facial aesthetic surgery, with detailed coverage of all the key techniques needed to achieve facial rejuvenation

    ·         The latest primary and revision breast surgery techniques for augmentation, reduction, mastopexy, fat grafting, and asymmetry management

    ·         Significant new chapters on minimally invasive treatments reflect enormous changes in this field since the last edition

    ·         The addition of two new dedicated sections on genital rejuvenation and gender affirming surgery

    ·         About 6,000 beautiful illustrations enhance understanding of state-of-the-art approaches

    ·         An expanded video library featuring 14 new clips and the addition of pre- and post-op patient images provides expert procedural guidance

    This quintessential resource provides trainees and experienced practitioners with a solid foundation for learning basic principles and techniques in aesthetic surgery, with the ultimate goal of improving patient outcomes, developing innovations, and advancing the specialty.

    This book includes complimentary access to a digital copy on



    Table of Contents


    Part I Fundamentals
    1 The Patient
    2 Psychological Considerations in Aesthetic Surgery
    3 Photographic Essentials in Aesthetic Surgery
    4 Patient Safety in Aesthetic Surgery
    5 Sedation and Anesthesia for Aesthetic Surgery
    Part II Business Basics
    6 Why Offer Aesthetic Medicine in an Aesthetic Surgical Practice?
    7 Optimal Correction and Patient Retention: A Personal Philosophical and Practical Approach to Your Nonsurgical Practice
    8 The Spa and the Law
    9 Social Media
    10 Hiring and Training a Superstar Patient-Care Coordinator
    11 Evidence-Based Pricing Strategies That Work
    Part III Nonsurgical Cosmetic Treatments
    12 Clinical Decision Making for Nonsurgical Cosmetic Treatments
    13 Over-the-Counter Skin Care and Nutraceutical Basics for the Aesthetic Surgeon
    14 A Scientific Approach to Cosmeceuticals
    15 Botulinum Toxin Injection for Facial Rejuvenation
    16 Soft-Tissue Fillers
    17 Non-Light-Based Skin Resurfacing
    18 Chemical Peels
    19 Lasers and Light-Based Devices in Plastic Surgery
    20 Sclerotherapy and Laser Vein Treatment
    21 Nonsurgical Treatment of the Face and Neck
    Part IV Hair Transplantation
    22 Applied Anatomy in Hair Transplantation
    23 Clinical Decision Making in Hair Transplantation
    24 Hair Transplantation: Follicular Unit Micrografting and Minigrafting—Current Techniques and Future Directions
    25 Reoperation, Refinement, and Treatment of Complications after Hair Transplantation
    Part V Brow Lift
    26 Clinical Decision Making in Brow Lift: Brow Rejuvenation
    27 Temporal Brow Lift
    28 Endoscopic Brow Lift
    29 Endoscopic Brow Lift: My Personal Approach
    30 Other Approaches to Brow Lift
    Part VI Eyelid Surgery
    31 Eyelid and Periorbital Anatomy
    32 Clinical Decision Making in Aesthetic Eyelid Surgery
    33 Upper Eyelid Blepharoplasty
    34 Upper Blepharoplasty in the Asian Patient
    35 Ptosis Surgery in the Blepharoplasty Patient
    36 Lower Eyelid Blepharoplasty
    37 Transconjunctival Blepharoplasty
    38 The Lower Eyelid Pinch Blepharoplasty
    39 Avoidance and Treatment of Complications of Aesthetic Eyelid Surgery

    Part VII Midface Rejuvenation
    40 Clinical Decision Making in the Midface
    41 Midface Recontouring
    42 Endoscopic Rejuvenation of the Midface
    Part VIII Surgical Rejuvenation of the Face and Neck
    43 Clinical Anatomy of the Face and Neck: Visualizing the Face
    44 Clinical Decision Making in Facelift and Neck Lift
    45 Structural Fat Grafting: Basics and Clinical Applications in the Hand and Face
    46 The MACS Lift Short-Scar Rhytidectomy with Fat Grafting
    47 Short-Scar Rhytidectomy
    48 Extended SMAS Technique in Facial Rejuvenation
    49 Lamellar High-SMAS Facelift: Single-Flap Lifting of the Midface, Cheek, and Jawline
    50 Simultaneous Facelift and Facial Fat Grafting
    51 Facial Implant Augmentation
    52 Neck Lift
    53 Secondary Neck Lift
    54 Reoperative Rhytidectomy
    55 Avoidance and Management of Complications in Facial Aesthetic Surgery
    Part IX Rejuvenation of the Cheeks, Chin, Lips, and Ears
    56 Rejuvenation of the Aging Mouth
    57 Refinements in Otoplasty Techniques
    58 Rejuvenation of the Chin
    Part X Rhinoplasty
    59 Applied Anatomy of the Nose
    60 Clinical Decision Making in Rhinoplasty
    61 Primary Rhinoplasty
    62 Tip Grafting for Nasal Contouring
    63 Asian Rhinoplasty
    64 Ethnic Rhinoplasty
    65 Revision Rhinoplasty

    Part XI Breast Surgery
    66 Applied Anatomy of the Breast
    67 The Process of Breast Augmentation: Optimizing Clinical Decisions and Outcomes in Breast Augmentation
    68 Choosing the Right Breast Implant
    69 Breast Augmentation
    70 Fat Grafting of the Breast
    71 Composite Primary and Revision Breast Augmentation
    72 Capsular Contracture: Current Science, Prevention, and Management
    73 Primary and Revision Augmentation Mastopexy: Techniques and Considerations
    74 Clinical Decision Making in Breast Reduction and Mastopexy
    75 Medial Pedicle Vertical Breast Reduction
    76 Breast Reduction: The Lateral Pedicle Technique
    77 Short-Scar Mammaplasty with a Pectoralis Loop
    78 Alternative Approaches to Breast Reduction
    79 Control and Precision in Mastopexy
    80 Mastopexy and Breast Reduction in Massive-Weight-Loss Patients
    81 Management of Breast Asymmetry
    82 Treatment of Gynecomastia
    Part XII Body Contouring
    83 Applied Anatomy in Body Contouring
    84 Clinical Decision Making in Body Contouring
    85 Noninvasive and Minimally Invasive Techniques for Body Contouring
    86 Liposuction and High Definition Liposculpture: Basic Techniques and Safety Considerations



  • 2950.00 lei

    The 9th Edition of the European Pharmacopoeia (EP), main volume and supplements, is legally binding and details the qualitative and quantitative composition of medicines, the tests to be carried out on medicines, the raw materials used in the production of medicines and on the intermediates of synthesis. The EP is a single reference work for the quality control of medicines in Europe. All producers of medicines or substances for pharmaceutical use must apply the quality standards of the European Pharmacopoeia for the marketing and use of these products in Europe. KEY FEATURES ? Applicable in 38 European countries and used in over 100 worldwide. ? Delivers crucial information earlier than any other Pharmacopoeia. ? Over 50% new or revised texts compared to the previous edition. ? Allows free access to the ?Knowledge? database and the online archives. PUBLICATIONS & IMPLEMENTATION DATES VOLUME PUBLICATION DATE IMPLEMENTATION DATE 9.6 July 2018 01 January 2019 9.7 October 2018 01 April 2019 9.8 January 2019 01 July 2019

  • European Pharmacopoeia Supplements 9.3-9.5
    by EDQM
    La comanda in aproximativ 4 saptamani
    2900.00 lei

    The 9th edition of the European Pharmacopoeia (EP), main volume and supplements, is legally binding and details the qualitative and quantitative composition of medicines, the tests to be carried out on medicines, the raw materials used in the production of medicines and on the intermediates of synthesis.

    The EP is a single reference work for the quality control of medicines in Europe. All producers of medicines or substances for pharmaceutical use must apply the quality standards of the European Pharmacopoeia for the marketing and use of these products in Europe.


    These supplements contain all the regulatory information that will come into force in the course of 2018. They complement the 9th Edition launched last year and bring the total number of monographs to 2351 (including dosage forms), along with 361 general texts (including general monographs and methods of analysis) and around 2670 descriptions of reagents.




    · Applicable in 38 European countries and used in over 100 worldwide.

    · Delivers crucial information earlier than any other Pharmacopoeia.

    · Over 50% new or revised texts compared to the previous edition.

    · All versions (online, print and the NEW downloads) allow free access to the Knowledge Database and the online archives.





    9.3 July 2017 01 January 2018

    9.4 October 2017 01 April 2018

    9.5 January 2018 01 July 2018


  • 3,29000lei 2700.00 lei

    This fourth edition of the Oxford Textbook of Clinical Nephrology builds on the success and international reputation of the publication as an important resource for the practising clinician in the field. It provides practical, scholarly, and evidence-based coverage of the full spectrum of clinical nephrology, written by a global faculty of experts. The most relevant and important reference to clinical nephrology, this is an authoritative and comprehensive textbook combining the clinical aspects of renal disease essential to daily clinical practice with extensive information about the underlying basic science and current evidence available. Each section of the textbook has been critically and comprehensively edited under the auspices of a leading expert in the field. This new edition has been significantly expanded and reapportioned to reflect developments and new approaches to topics, and includes treatment algorithms to aid and enhance patient care where possible. The fourth edition offers increased focus on the medical aspects of transplantation, HIV-associated renal disease, and infection and renal disease, alongside entirely new sections on genetic topics and clinical and physiological aspects of fluid/electrolyte and tubular disorders. The emphasis throughout is on marrying advances in scientific research with clinical management. Richly illustrated throughout in full colour, this is a truly modern and attractive edition which reinforces the Oxford Textbook of Clinical Nephrology's position as an indispensable reference work of consistent quality and reliability. Enriched and refined by careful revision, this new edition continues the tradition of excellence.

  • 3,08900lei 2625.00 lei


    Sixth edition includes three new chapters and remaining chapters extensively updated and revised to include the latest clinical, radiological, and pathological data and clinical trial advances

    Written by leading melanoma experts from the United States, Australia, and Europe

    Incorporates clinical outcomes of more than 70,000 patients treated at major melanoma centers throughout the world

    The definitive and most authoritative textbook on melanoma used worldwide

    Offers the reader a balanced perspective of the risks and benefits involved in each treatment modality


    About this book


    Written by the leading melanoma experts from the United States, Australia, and Europe, this new edition incorporates the clinical outcomes of more than 70,000 patients treated at major melanoma centers throughout the world and is the definitive and most authoritative textbook on melanoma used worldwide. Providing the most up-to-date and comprehensive information needed for the clinical management and scientific study of melanoma, Cutaneous Melanoma, 6th edition covers everything from precursors of melanoma to advanced stages of metastatic disease.


    Table of Contents:


    Front Matter

    Pages i-xxix

    Biology and Immunology of Melanoma

    Front Matter

    Pages 1-1

    Biology of Melanocytes and Primary Melanoma

    M. Raza Zaidi, David E. Fisher, Helen Rizos

    Pages 3-40

    Immunology of Melanoma

    Paul F. Robbins, Yong-Chen Lu

    Pages 41-72

    Biomarkers for Melanoma

    Dirk Schadendorf, Keith T. Flaherty, Lyn M. Duncan, Mohammed Kashani-Sabet, Selma Ugurel

    Pages 73-104

    Diagnosis and Staging

    Front Matter

    Pages 105-105

    Clinical Presentations of Melanoma

    Allan C. Halpern, Ashfaq A. Marghoob, Arthur J. Sober, Victoria Mar, Michael A. Marchetti

    Pages 107-144

    Dermoscopy/Confocal Microscopy for Melanoma Diagnosis

    Katie J. Lee, Nicola di Meo, Oriol Yélamos, Josep Malvehy, Iris Zalaudek, H. Peter Soyer

    Pages 145-194

    Biopsy of Suspected Melanoma

    Noah Smith, Timothy M. Johnson, John W. Kelly, Arthur J. Sober, Christopher Bichakjian

    Pages 195-203

    Lymphoscintigraphy in Patients with Melanoma

    Roger F. Uren, Omgo E. Nieweg, John F. Thompson

    Pages 205-237

    Biopsy of the Sentinel Lymph Node

    Mark B. Faries, Alistair J. Cochran, Michael McLemore, Vernon K. Sondak, Sandra L. Wong, John F. Thompson

    Pages 239-270

    Melanoma Prognosis and Staging

    Emily Z. Keung, Charles M. Balch, John F. Thompson, John M. Kirkwood, Richard A. Scolyer, Vernon K. Sondak et al.

    Pages 271-297

    Models for Predicting Melanoma Outcome

    Lauren E. Haydu, Phyllis A. Gimotty, Daniel G. Coit, John F. Thompson, Jeffrey E. Gershenwald

    Pages 299-314


    Front Matter

    Pages 315-315

    Classification and Histopathology of Melanoma

    Richard A. Scolyer, Victor G. Prieto, David E. Elder, Alistair J. Cochran, Martin C. Mihm

    Pages 317-379

    Molecular Pathology and Genomics of Melanoma

    Klaus Georg Griewank, Rajmohan Murali, Thomas Wiesner

    Pages 381-422

    Epidemiology and Prevention of Melanoma

    Front Matter

    Pages 423-423

    Clinical Epidemiology of Melanoma

    Catherine M. Olsen, David C. Whiteman

    Pages 425-449

    Molecular Epidemiology of Melanoma

    Anne E. Cust, Hensin Tsao, Marianne Berwick, Graham J. Mann, Mark M. Iles

    Pages 451-469

    Clinical Genetics and Risk Assessment of Melanoma

    V. Bataille, Hensin Tsao, S. Raimondi, S. Gandini

    Pages 471-499

    Acquired Precursor Lesions and Phenotypic Markers of Increased Risk for Cutaneous Melanoma

    Cristian Navarrete-Dechent, Alon Scope, Hensin Tsao, Nadeem G. Marghoob, Arthur J. Sober, Ashfaq A. Marghoob

    Pages 501-524

    Melanoma Prevention and Screening

    Susan M. Swetter, Alan C. Geller, Sancy A. Leachman, John M. Kirkwood, Alexander Katalinic, Jeffrey E. Gershenwald

    Pages 525-570

    Management of Primary Melanoma and Locoregional Metastases

    Front Matter

    Pages 571-571

    Treatment of Primary Melanomas

    John F. Thompson, Michael A. Henderson, Gabrielle Williams, Merrick I. Ross

    Pages 573-594

    Reconstructive Options Following Surgery of Primary Melanoma

    Marc Moncrieff, Brian Gastman, Rogerio Izar Neves, Howard Peach, Anthony P. Tufaro

    Pages 595-656

    Axillary and Epitrochlear Lymph Node Dissection for Melanoma

    Sandra L. Wong, Douglas S. Tyler, Charles M. Balch, John F. Thompson, Kelly M. McMasters

    Pages 657-667

    Inguinofemoral, Iliac/Obturator, and Popliteal Lymphadenectomy for Melanoma

    Keith A. Delman, Lesly A. Dossett, Clara R. Farley, Kelly M. McMasters, Omgo E. Nieweg

    Pages 669-687

    Neck Dissection and Parotidectomy for Melanoma

    Brian Gastman, Rebecca Knackstedt, Ryan P. Goepfert, Baran Sumer, Ashok Shaha, Michael E. Kupferman

    Pages 689-704

    Local and Recurrent Regional Metastases of Melanoma

    Matthew C. Perez, Kenneth K. Tanabe, Charlotte E. Ariyan, John T. Miura, Dorotea Mutabdzic, Jeffrey M. Farma et al.

    Pages 705-737

    Radiotherapy for Primary and Regional Melanoma

    Angela M. Hong, Graham Stevens

    Pages 739-745

    Adjuvant Systemic Therapy for High-Risk Melanoma Patients

    Yana G. Najjar, Ryan Massa, Vernon K. Sondak, Alexander M. M. Eggermont, Helen Gogas, John M. Kirkwood

    Pages 747-766

    Neoadjuvant Systemic Therapy for High-Risk Melanoma Patients

    Emily Z. Keung, Rodabe N. Amaria, Vernon K. Sondak, Merrick I. Ross, John M. Kirkwood, Jennifer A. Wargo

    Pages 767-793

    Hyperthermic Regional Perfusion for Melanoma of the Limbs

    Douglas S. Tyler, Douglas L. Fraker, Harald J. Hoekstra, H. Richard Alexander Jr.

    Pages 795-825

    Isolated Limb Infusion for Melanoma

    Georgia Marie Beasley, John T. Miura, Jonathan S. Zager, Douglas S. Tyler, John F. Thompson, Hidde M. Kroon

    Pages 827-850

    Surveillance and Follow-Up of Melanoma Patients

    Rachael L. Morton, Anne Brecht Francken, Mbathio Dieng

    Pages 851-866

    Local Melanoma Recurrence, Satellitosis, and In-transit Metastasis: Incidence, Outcomes, and Selection of Treatment Options

    John F. Thompson, Nicola Mozzillo, Merrick I. Ross

    Pages 867-894

    Uncommon Presentations of Melanoma

    Front Matter

    Pages 895-895

    Acral Lentiginous Melanoma

    Yukiko Teramoto, Hector Martinez-Said, Jun Guo, Claus Garbe

    Pages 897-924

    Lentigo Maligna Melanoma

    Cristian Navarrete-Dechent, Kelly C. Nelson, Anthony M. Rossi, Erica H. Lee, Christopher A. Barker, Kishwer S. Nehal et al.

    Pages 925-951

    Mucosal Melanoma

    Michael A. Henderson, Charles M. Balch, Claus Garbe, Alexander N. Shoushtari, Bin Lian, Chuanliang Cui et al.

    Pages 953-968

    Melanoma in Children and Teenagers

    Ines B. Brecht, Ira J. Dunkel, Claus Garbe

    Pages 969-982

    Pregnancy and the Use of Hormones in Melanoma Patients

    Alexandra Gangi, Robyn Saw, Vernon K. Sondak

    Pages 983-996

    Diagnosis of Stage IV Melanoma

    Ahmad A. Tarhini, Sanjiv S. Agarwala, Arjun Khunger, Richard L. Wahl, Charles M. Balch

    Pages 997-1043

    Management of Distant Metastases

    Front Matter

    Pages 1045-1045

    Evolving Role of Chemotherapy-Based Treatment of Metastatic Melanoma

    Sanjiv S. Agarwala, Mark R. Middleton, Michael B. Atkins

    Pages 1047-1066

    Targeted Therapies for BRAF-Mutant Metastatic Melanoma

    Douglas B. Johnson, Reinhard Dummer, Keith T. Flaherty, Keiran S. Smalley

    Pages 1067-1085

    Molecularly Targeted Therapy for Patients with BRAF Wild-Type Melanoma

    Sunandana Chandra, Grant A. McArthur, Jeffrey Sosman

    Pages 1087-1108

    Cytokines (IL-2, IFN, GM-CSF, etc.) Melanoma

    John B. A. G. Haanen, Ryan J. Sullivan, John M. Kirkwood, Michael B. Atkins, Douglas J. Schwartzentruber

    Pages 1109-1140

    Checkpoint Inhibitors in the Treatment of Metastatic Melanoma

    Alison Weppler, Peter Lau, Grant A. McArthur

    Pages 1141-1164

    Novel Immunotherapies and Novel Combinations of Immunotherapy for Metastatic Melanoma

    Daniel J. Olson, Rodolfo Gutierrez, Salah Eddine Bentebibel, Randy F. Sweis, Omid Hamid, Adi Diab et al.

    Pages 1165-1186

    Management of Distant Metastases

    Managing Checkpoint Inhibitor Symptoms and Toxicity for Metastatic Melanoma

    Anna Pavlick, Jeffrey Weber

    Pages 1187-1214

    Sequencing and Combinations of Molecularly Targeted and Immunotherapy for BRAF-Mutant Melanoma

    Paolo A. Ascierto, Michael B. Atkins

    Pages 1215-1241

    Melanoma Vaccines

    Peter Hersey, Stuart J. Gallagher, John M. Kirkwood, Jonathan Cebon

    Pages 1243-1265

    Cellular Therapy for Melanoma

    Udai S. Kammula, Michael T. Lotze

    Pages 1267-1299

    Systemic Therapy for Mucosal, Acral, and Uveal Melanoma

    Suthee Rapisuwon, Yong Qin, Jason Roszik, Fernando Carapeto, Sapna Patel, Richard D. Carvajal

    Pages 1301-1335

    Dermatological Complications of Systemic Therapies for Melanoma

    Egle Ramelyte, Reinhard Dummer, Cristina Libenciuc, Gregory S. Phillips, Mario E. Lacouture, Caroline Robert

    Pages 1337-1358

    Surgical Management of Distant Melanoma Metastases

    John F. Thompson, Mark B. Faries, Erica B. Friedman, Jeffrey E. Lee, Charles M. Balch

    Pages 1359-1402

    Radiotherapy for Distant Melanoma Metastases

    Angela M. Hong, Christopher A. Barker

    Pages 1403-1420

    Melanoma Brain Metastases: Unique Biology and Implications for Systemic Therapy

    Kim Margolin, Michael Davies, Harriet Kluger, Hussein Tawbi

    Pages 1421-1454

    History of Melanoma

    Front Matter

    Pages 1455-1455

    A History of Melanoma: From Hunter to Morton

    Arthur J. Sober, Charles M. Balch, John F. Thompson, John M. Kirkwood

    Pages 1457-1475

    Back Matter

    Pages 1477-1510


  • 2,88000lei 2600.00 lei


    • The definitive major reference work in the field, covering key information that the infectious diseases specialist will need to know about antimicrobial drugs
    • Comprehensive coverage of the drug available, including those new to the market and, importantly, those currently under trial
    • Highly standardized content, structured for ease of reference
    • Globally applicable, compiled by an international team of expert editors and contributors
    • Added to this edition - new antivirals, particularly the highly effective compounds now available to treat HIV and viral hepatitis; new antibiotics - beta-lactamase inhibitors and cephalosporins, quinolones and fluoroquinolones, anti-tuberculosis agents; plus new antifungals and antiparasitics.


    Kucers’ The Use of Antibiotics is the definitive, internationally-authored reference, providing everything that the infectious diseases specialist and prescriber needs to know about antimicrobials in this vast and rapidly developing field. The much-expanded Seventh Edition comprises 4800 pages in 3 volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into four sections - antibiotics, anti-fungal drugs, anti-parasitic drugs, and anti-viral drugs - and is highly structured for ease of reference.

    Each chapter is organized in a consistent format, covering susceptibility, formulations and dosing (adult and pediatric), pharmacokinetics and pharmacodynamics, toxicity, and drug distribution, with detailed discussion regarding clinical uses - a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with expert contributors representing Europe, Africa, Asia, Australia, South America, the US, and Canada, the Seventh Edition adopts a truly global approach. It remains invaluable for anyone using antimicrobial agents in their clinical practice and provides, in a systematic and concise manner, all the information required when prescribing an antimicrobial to treat infection.

    Table of Contents

    Foreword, Obituary: Dr. Alvis Kucers, Hail the Greats, Preface, Abbrieviations. 

    SECTION I Introduction.

    SECTION II Antibiotics: Part 1 Penicillins and related drugs, Part 2 Cephalosporins and related drugs, Part 3 Carbapenems, Part 4 Glycopeptides and lipopeptides, Part 5 Aminoglycosides, Part 6 Macrolides and Ketolides, Part 7 Tetracyclines and related drugs, Part 8 Other antibiotics, Part 9 Anti-folate agents and other synthetic antibacterials, Part 10 Nitroimidazoles, Part 11 Quinolones and Fluoroquinolones. Part 12 Anti-tuberculosis drugs.

    SECTION III Antifungal drugs: Part 1 Polyenes, Part 2 Echinocandins, Part 3 Allylamines and benzylamine derivatives, Part 4 Systemic azoles, Part 5 Topical azoles, Part 6 Topical agents—thiocarbomates, hydroxypyridones, and morpholine, Part 7 Other antifungal agents.

    SECTION IV Antiparasitic drugs: Part 1 Anti-malarial drugs, Part 2 Agents active against intestinal and extra-intestinal protozoa, Part 3 Agents active against American trypanosomiasis, Part 4 Agents active against African trypanosomiasis, Part 5 Agents active against leishmania and other pathogens, Part 6 Agents active against helminths, Part 7 Agents active against ectoparasites.

    SECTION V Antiviral drugs: Part 1 Agents active against herpesviruses, Part 2 Agents active against the human immunodeficiency virus, Part 3 Agents active against hepatitis viruses, Part 4 Agents active against influenza viruses, Part 5 Investigational antiviral drugs.

  • 3,03100lei 2600.00 lei

    Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. A new addition to the best-selling Operative Techniques series, Operative Techniques in Plastic Surgery provides superbly illustrated, authoritative guidance on operative techniques along with a thorough understanding of how to select the best procedure, how to avoid complications, and what outcomes to expect. Easy to follow, up to date, and highly visual, this step-by-step reference covers nearly all operations in current use in plastic surgery, and is ideal for residents and physicians in daily practice. Comprehensively covers all areas of plastic surgery including facial aesthetic, breast, hand, trunk reconstruction and body contouring, head and neck reconstruction, craniofacial trauma and reconstruction, lower limb reconstruction, and pediatric plastic surgery. Succinct text, bulleted points, and quick-reference tables allow you to review information quickly and understand best practices and potential problems for each procedure. Hundreds of full-color intraoperative photographs and illustrations, as well as numerous high-quality videos, capture procedures step by step and help you immediately apply your knowledge. Each clinical problem is discussed in the same templated format: definition, anatomy, patient history and physical findings, imaging, differential diagnosis, nonoperative management where applicable, surgical management including preoperative planning and approach, step-by-step surgical techniques, pearls and pitfalls, postoperative care, outcomes, complications, and references. Perfect for a quick preoperative review of the steps of a procedure. Editors and contributors are globally renowned authorities in their respective subspecialties and are known for their surgical expertise. Enhance Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

  • 3,10000lei 2500.00 lei

    A comprehensive review of the current status of antidepressants - how we arrived at this point in their evolution and where we are going in both the near and the long term. It employs both a scientific and historical approach to accomplish these goals. This volume is intended for practitioners who use antidepressants on a daily basis in their practice as well as for the student and researcher. Each will find that it provides a comprehensive and logical approach to this important group of medications. This book is being published as we mark the end of the first 50 years of the modern antidepressant era.

  • 2,57300lei 2500.00 lei

    Still the most comprehensive reference available on surgical flaps, this classic two volume text has combine content from three previous volumes into two and remains your go-to source for practical, authoritative guidance on achieving the best possible outcomes for your patients. The thoroughly revised 4th Edition features an all-new, full-color format that greatly enhances its visual appeal and usefulness in your everyday practice. Dozens of internationally recognized experts describe every clinical proven flap option available for repairing both routine and unusual problems, lavishly illustrated with clinical photographs and diagrams of anatomy, blood supply, flap design, and operative procedures. Extensively indexed and organized by anatomic region, chapters follow a logical format that clearly presents all the information you need to know: indications, anatomy, blood supply, surgical techniques, complications, safeguards to keep in mind, and advantages and disadvantages of each flap. This comprehensive, clinically relevant information allows you to select the best flaps for safe, predictable, and aesthetically desirable results for every patient. Key Features * The most current, complete, and relevant reference available to date in the fast-changing field of plastic and reconstructive surgery.* A new full-color design throughout, with redrawn illustrations, color figures, and vibrant clinical photographs, enhances the clinical usefulness of the text.*Thirty three new chapters cover recent developments in the field, includingsupraclavicular artery island flap, fat grafting for breast reconstruction revision, , split gluteal muscle flap for autoprosthesis buttock augmentation, flaps, and .*Updated content on innovative perforator flaps that have led to more versatile flap designs in nearly all areas of the body, with the added benefit of limiting donor site morbidity and expanded applications of "propeller" flaps.* Chapters on less commonly used flaps moved online to preserve the encyclopedic scope of the reference, yet also maintain a manageable size in the print edition.*Clinically useful editorial comments throughout that reflect the four editors' more than 100 years of collective experience.Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like:*Complete content with enhanced navigation*Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web*Cross-linked pages, references, and more for easy navigation*Highlighting tool for easier reference of key content throughout the text* Ability to take and share notes with friends.<\\\\p>

  • Metabolic Syndrome: A Comprehensive Textbook
    La comanda in aproximativ 4 saptamani
    3,10000lei 2500.00 lei

    This comprehensive reference work edited by one of the leading authorities on obesity presents an up-to-date survey of the current scientific understanding of the metabolic syndrome, as well as an overview of the most significant changes to the field over the past 30 years. This volume is a thorough reference for obesity and the metabolic syndrome and will prove an indispensable resource for clinicians and researchers at levels worldwide.​ The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. In addition, when combined with other comorbidities such as hypertension and dyslipidemia, obesity often leads to a patient diagnosis of metabolic syndrome, a very troubling condition that has grown, and is continuing to grow, rapidly each year in prevalence worldwide. Metabolic syndrome is a cluster of conditions ― increased blood pressure, a high blood sugar level, excess body fat around the waist and abnormal cholesterol levels ― that occur together, increasing one’s risk of heart disease, stroke and diabetes. This resource covers the full range of scientific and clinical aspects: epidemiology, genetics, environmental factors, pathophysiology, diseases associated with obesity, and clinical management

  • 2,74600lei 2500.00 lei


    Offering a comprehensive, authoritative review of today’s orthopaedic surgery procedures, Operative Techniques in Orthopaedic Surgery, Third Edition, provides lavishly illustrated, expert guidance for virtually any orthopaedic procedure you’re likely to perform. This highly acclaimed reference focuses on mastery of operative techniques while also providing a thorough understanding of how to select the best procedure, how to avoid complications, and what outcomes to expect. More than 1,000 global experts take you step by step through each procedure, and 13,000 full-color intraoperative photographs and drawings clearly demonstrate how to perform the techniques, making this an essential daily resource for residents, fellows, and practitioners. 


    • Includes new procedures and comprehensive updates throughout all four volumes. 
    • Provides new procedural videos and a newly streamlined eBook for on-the-go reference. 
    • Covers all subspecialty areas including sports medicine, pediatrics, the spine, and orthopaedic oncology. 
    • Uses consistent, easy-to-follow chapter templates and extensive bulleted lists and tables for quick reference and review. 
    • Discusses each clinical problem using the same format: definition, anatomy, physical exams, pathogenesis, natural history, physical findings, imaging and diagnostic studies, differential diagnosis, non-operative management, surgical management, perils and pitfalls, postoperative care, outcomes, and complications. 
    • Features visually stunning, consistently rendered medical illustrations and labelled photographs that present how to perform each technique step by step. 

    Enrich Your eBook Reading Experience 

    • Read directly on your preferred device(s), such as computer, tablet, or smartphone. 
    • Easily convert to audiobook, powering your content with natural language text-to-speech. 

    Table of Contents:

    Preface xxxix
    Preface to the Second Edition xli
    Preface to the First Edition xliii
    VOLUME 1
    SECTION I Shoulder

    SECTION II Elbow
    SECTION I Pelvis and Hip
    SECTION II Femur and Knee
    SECTION IV Foot and Ankle
    SECTION I Hip Reconstruction
    SECTION II Hip Preservation
    SECTION III Knee Reconstruction
    VOLUME 2
    SECTION I Trauma
    SECTION II Arthroscopic and Sports Medicine
    SECTION III Reconstruction
    SECTION IV Neuromuscular Correction
    SECTION V Cysts
    SECTION VI Upper Extremity
    SECTION IX Foot and Ankle
    SECTION I Surgical Management
    SECTION II Shoulder Girdles and Upper Extremity
    SECTION III Spine and Pelvis
    SECTION IV Lower Extremities
    VOLUME 3
    SECTION I Evaluation and Anesthesia
    SECTION III Carpal Fractures, Avascular Necrosis and Instability
    SECTION IV Radius and Ulna Fractures and Dislocations
    SECTION V Hand and Wrist Arthroscopy
    SECTION VI Tendon Injuries and Disorders
    SECTION VII Nerve Injury and Compression
    SECTION VIII Hand and Wrist Arthritis
    SECTION IX Compartment Syndrome, Vascular Disorders and Infection
    SECTION X Soft Tissue Coverage, Contractures and Thermal Injuries
    SECTION I Anatomy and Approaches
    SECTION II Glenohumeral Instability
    SECTION III Rotator Cuff and Biceps
    SECTION IV Acromioclavicular Joint, Sternoclavicular
    SECTION V Humeral and Scapula Fractures
    SECTION VI Glenohumeral Arthritis
    SECTION VII Muscle Ruptures, Scapulothoracic Articulation, and Nerve Problems

    SECTION VIII Tendon Disorders of the Elbow
    SECTION IX Elbow Stiffness
    SECTION X Elbow Trauma
    SECTION XI Elbow Arthritis
    VOLUME 4
    SECTION I Forefoot
    SECTION II Midfoot
    SECTION III Hindfoot
    SECTION IV Ankle
    SECTION V Sports-Related Procedures for
    Index I-1


  • 2,80800lei 2480.00 lei

    Because pediatric orthopedic trauma involves fixing bones that are still growing, it has unique concerns and complexities that distinguish it from adult orthopedic trauma. Unlike previous books on this topic, this book utilizes a case atlas format to provide current management strategies for pediatric orthopedic injuries to the upper and lower extremity and axial skeleton in a clear and concise manner, demonstrating real-world clinical situations and methodology for successful treatment. Each case will be authored by an expert in the field and will contain comprehensive step-by-step instructions on how to handle each injury. In addition to pre-operative, intra-operative, and post-operative recommendations, each case will include multiple color images and radiographs, clinical pearls, and possible pitfalls to further guide the reader and provide the orthopedic surgeon, resident and fellow with quick, credible and reliable answers to “How do I fix this?”

  • 2410.00 lei

    This landmark book, a reference work now in its second edition, provides healthcare practitioners in neonatology with an up-to-date, comprehensive source of readily accessible practical advice that will assist in the expert management of patients and their diverse illnesses. Leading experts in their fields discuss the underlying causes and mechanisms and all aspects of the treatment of the full range of neonatal diseases and abnormalities, citing the evidence base whenever appropriate. In addition, detailed information is provided on epidemiology and fetal medicine; therapeutic issues such as the organization of care, transport services, and home care after discharge; legal issues; nutrition; and the consequences of medication use during pregnancy, maternal drug abuse and smoking, and maternal diabetes. The inclusion of summaries, tables, and carefully selected guidelines and recommendations will supply practitioners with quick references and instant solutions during daily practice. The book will be a superb resource for all involved in the care of newborn babies, including neonatologists, pediatricians, pediatric surgeons, anesthesiologists, midwives, and nursing staff. It is published within the SpringerReference program, which delivers access to living editions constantly updated through a dynamic peer-review publishing process.

  • 2,86600lei 2400.00 lei


    The undisputed gold standard text in the field, Ryan's Retina is your award-winning choice for the most current, authoritative information on new technologies, surgical approaches, scientific advances and diagnostic and therapeutic options for retinal diseases and disorders. Packed with timely updates throughout, new illustrations, and a dedicated team of editors who extend Dr. Ryan’s legacy in retina, this outstanding 6th Edition is a must-have reference for retinal specialists, ophthalmologists, and fellows in training.


    • Offers the most comprehensive content available on retina, balancing the latest scientific research and clinical correlations, covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology.
    • Provides a truly global perspective from five highly esteemed section editors and more than 350 other world authorities from across Europe, Asia, Australasia, and the Americas.

    New To This Edition:

    • Bullets Includes new chapters on widefield imaging, intraoperative OCT imaging, medical management of diabetes mellitus and age-related macular degeneration, and senile retinoschisis.
    • Includes more than 1,150 brand-new illustrations, scans, and photographs throughout.
    • Covers the explosion of new imaging options across optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging, including a greatly expanded OCT imaging chapter that features crucial information on OCT-Angiography (OCT-A).
    • Presents new pharmacotherapy data and the latest approaches in anti-VEGF therapy for age-related macular degeneration, diabetic retinopathy, and venous occlusive disease.
    • Features an expanded online video library highlighting the latest surgical techniques and new coverage of complications of vitreoretinal surgery.
    • Contains thorough content updates in every area of retina, including advanced imaging technologies, gene therapy, inflammation and immune responses, white dot syndromes, epigenetic mechanisms, transplantation frontiers to improve retinal function, macular hole, myopic eye disease, ocular trauma, drug delivery to the posterior segment, advances in macular surgery, vitrectomy and complex retinal detachment, tumors, and retinal genetics and biology.
    • Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.

    Table Of Contents:

    Part I: Retinal Imaging and Diagnostics

    1. Fluorescein Angiography: Basic Principles and Interpretation

    2. Clinical Applications of Diagnostic Indocyanine Green Angiography

    3. Optical Coherence Tomography

    4. Autofluorescence Imaging

    5. Widefield Imaging

    6. Intraoperative OCT Imaging

    7. Advanced Imaging Technologies

    8. Advanced Image Analysis

    9. Electrogenesis of the Electroretinogram

    10. Clinical Electrophysiology

    11. Diagnostic Ophthalmic Ultrasound

    12. Color Vision and Night Vision

    13. Visual Acuity and Contrast Sensitivity

    14. Visual Fields in Retinal Disease


    Part 2: Basic Science and Translation to Therapy

    Section 1: Anatomy and Physiology

    15. The Development of the Retina

    16. Structure and Function of Rod and Cone Photoreceptors

    17. Function and Anatomy of the Mammalian Retina

    18. Cell Biology of the Retinal Pigment Epithelium

    19. Cell Biology of Retinal Glia

    20. Retinal and Choroidal Vasculature: Retinal Oxygenation

    21. Mechanisms of Normal Retinal Adhesion

    22. Structure, Function, and Pathology of Bruch’s Membrane

    23. Vitreous and Vitreoretinal Interface

    Section 2: Basic Mechanisms of Injury in the Retina

    24. Mechanisms of Oxidative Stress in Retinal Injury

    25. Mechanisms of Endoplasmic Reticulum Stress in Retinal Disease

    26. Cell Death, Apoptosis, and Autophagy in Retinal Injury

    27. Inflammation and Immune Responses In Retinal Health and Disease

    28. Basic Mechanisms of Pathological Retinal and Choroidal Angiogenesis

    29. Blood-Retinal Barrier, Immune Privilege, and Autoimmunity

    30. Mechanisms of Macular Edema and Therapeutic Approaches

    31. Cellular Effects of Detachment and Reattachment on the Neural Retina and the Retinal Pigment Epithelium

    32. Pathogenesis of Serous Detachment of the Retina and Pigment Epithelium


    Section 3: Genetics

    33. Genetic Mechanisms of Retinal Disease

    34. Mitochondrial Genetics of Retinal Disease

    35. Epigenetic Mechanisms of Retinal Disease


    Section 4: Translational Basic Science

    36. Gene Therapy for Retinal Disease

    37. Stem Cells and Cellular Therapy

    38. Nanomedicine in Ophthalmology

    39. Neuroprotection

    40. Drug Delivery

    41. Retinal Laser Therapy: Biophysical Basis and Applications


    Medical Retina

    Section 1: Retinal Degenerations and Dystrophies

    42. Retinitis Pigmentosa and Allied Disorders

    43. Hereditary Vitreoretinal Degenerations

    44. Macular Dystrophies

    45. Hereditary Choroidal Diseases

    46. Abnormalities of Cone and Rod Function


    Section 2: Retinal Vascular Disease

    47. The Epidemiology of Diabetic Retinopathy

    48. Diabetic Retinopathy: Genetics and Etiologic Mechanisms

    49. Medical Management of Diabetes Mellitus

    50. Nonproliferative Diabetic Retinopathy and Diabetic Macular Edema

    51. Proliferative Diabetic Retinopathy

    52. Hypertension

    53. Telescreening for Diabetic Retinopathy

    54. Retinal Artery Occlusions

    55. Acquired Retinal Macroaneurysms

    56. Branch Vein Occlusion

    57. Central Retinal Vein Occlusion

    58. Macular Telangiectasia

    59. Coats Disease

    60. Hemoglobinopathies

    61. Radiation Retinopathy

    62. Ocular Ischemic Syndrome

    63. Coagulopathies

    64. Pediatric Retinal Vascular Diseases Retinopathy of Prematurity

    65. Telescreening for Retinopathy of Prematurity


    Section 3: Choroidal Vascular/Bruch's Membrane Disease

    66. Epidemiology and Risk Factors for Age-Related Macular Degeneration

    67. Pathogenetic Mechanisms in Age-Related Macular Degeneration

    68. Age-Related Macular Degeneration: Non-neovascular Early AMD, Intermediate AMD, and Geographic Atrophy

    69. Neovascular (Exudative or "Wet") Age-Related Macular Degeneration

    70. Pharmacotherapy of Age-Related Macular Degeneration

    71. Pathologic Myopia

    72. Angioid Streaks

    73. Ocular Histoplasmosis

    74. Polypoidal Choroidal Vasculopathy

    75. Central Serous Chorioretinopathy

    76. Uveal Effusion Syndrome and Hypotony Maculopathy


    Section 4: Inflammatory Disease/Uveitis

    77. Sympathetic Ophthalmia

    78. Vogt-Koyanagi-Harada Disease

    79. White Spot Syndromes and Related Diseases

    80. Autoimmune Retinopathies

    81. Sarcoidosis

    82. Intermediate Uveitis

    83. Rheumatic Diseases

    84. HIV-Associated Infections

    85. Mycobacterial Infections

    86. Eales Disease

    87. Spirochetal Infections

    88. Ocular Toxoplasmosis

    89. Helminthic Disease

    90. Endogenous Endophthalmitis: Bacterial and Fungal

    91. Acute Retinal Necrosis Syndrome


    Section 5: Miscellaneous

    92. Drug Toxicity of the Posterior Segment

    93. Photic Retinal Injuries: Mechanisms, Hazards, and Prevention

    94. Traumatic Chorioretinopathies

    95. Pregnancy-Related Diseases

    96. Optic Disc Anomalies, Pits, and Associated Serous Macular Detachment

    97. Retina-Related Clinical Trials: A Resource Bibliography


    Surgical Retina

    Section 1: The Pathophysiology of Retinal Detachment and Associated Problems

    98. Pathogenetic Mechanisms of Retinal Detachment

    99. Nonrhegmatogenous Retinal Detachment

    100. Senile Retinoschisis

    101. Pathogenesis of Proliferative Vitreoretinopathy

    102. Pathophysiology of Ocular Trauma


    Section 2: Retinal Reattachment: General Surgical Principles and Techniques

    103. The Effects and Action of Scleral Buckles in the Treatment of Retinal Detachment

    104. Techniques of Scleral Buckling

    105. Principles and Techniques of Vitreoretinal Surgery

    106. Primary Vitrectomy in Rhegmatogenous Retinal Detachment

    107. Pneumatic Retinopexy

    108. Special Adjuncts to Treatment

    109. Optimal Procedures for Retinal Detachment Repair

    110. Prevention of Retinal Detachment


    Section 3: Complicated Forms of Retinal Detachment

    111. Proliferative Vitreoretinopathy

    112. Retinotomies and Retinectomies

    113. Giant Retinal Tear

    114. Surgery for Ocular Trauma: Principles and Techniques of Treatment

    115. Surgery for Proliferative Diabetic Retinopathy

    116. Management of Combined Inflammatory and Rhegmatogenous Retinal Detachment

    117. High Myopia and the Vitreoretinal Complications

    118. Surgical Management of Retinopathy of Prematurity

    119. Surgery for Pediatric Vitreoretinal Disorders

    Section 4: Vitreous Surgery for Macular Disorders

    120. Epiretinal Membranes, Vitreoretinal Traction and Cystoid Macular Edema

    121. Macular Hole

    122. Surgical Management of Choroidal Neovascularization and Subretinal Hemorrhage

    123. 360 Degree Macular Translocation

    124. Retinal Pigment Epithelium and Choroid Translocation in Patients with Age-Related Macular Degeneration


    Section 5: Vitreous Surgery: Additional Considerations

    125. Infectious Endophthalmitis

    126. Diagnostic and Therapeutic Vitrectomy for Uveitis

    127 . Vitreous, Retinal, and Choroidal Biopsy

    128. Transplantation Frontiers

    129 . Artificial Vision

    130. Pharmacology During Surgery

    131. Complications In Vitreoretinal Surgery


    Tumors of the Retina, Choroid, and Vitreous

    Section 1: Tumors of the Retina

    132. Retinoblastoma

    133. Cavernous Hemangioma

    134. Capillary Hemangioblastoma of the Retina and von Hippel-Lindau Disease

    135. Tuberous Sclerosis and the Eye

    136. Phakomatoses

    137. Retinal Metastases

    138. Remote Effects of Cancer on the Retina

    139. Melanocytoma of the Optic Disc

    140. Congenital Hypertrophy of the Retinal Pigment Epithelium

    141. Combined Hamartoma of the Retinal Pigment Epithelium and Retina


    Section 2: Tumors of the Choroid

    142. Choroidal Nevi

    143. Epidemiology of Posterior Uveal Melanoma

    144. Prognosis of Posterior Uveal Melanoma

    145. Molecular Genetics of Choroidal Melanoma

    146. Pathology of Choroidal Melanoma

    147. Overview of Management of Posterior Uveal Melanoma

    148. Enucleation for Choroidal Melanomas

    149. Brachytherapy for Choroidal Melanoma

    150. Charged-Particle Irradiation of Uveal Melanoma

    151. Surgical Resection of Choroidal Melanoma

    152. Laser Treatment of Choroidal Melanoma

    153. Systemic Evaluation and Management of Patients with Metastatic Uveal Melanoma

    154. Collaborative Ocular Melanoma Study

    155. Choroidal Metastases

    156. Choroidal Osteoma

    157. Circumscribed Choroidal Hemangioma


    Section 3: Hematologic and Miscellaneous Tumors

    158. Miscellaneous Uveal Tumors

    159. Leukemias and Lymphomas

    160. Primary Vitreoretinal Lymphoma



  • 2,97400lei 2400.00 lei

    Scott-Brown's Otorhinolaryngology is used the world over as the definitive reference for trainee ENT surgeons, audiologists and trainee head and neck surgeons, as well as specialists who need detailed, reliable and authoritative information on all aspects of ear, nose and throat disease and treatment. Key points: ? accompanied by a fully searchable electronic edition, making it more accessible, containing the same content as the print edition, with operative videos and references linked to Medline ? highly illustrated in colour throughout to aid understanding ? updated by an international team of editors and contributors ? evidence-based guidelines will help you in your clinical practice ? features include key points, best clinical practice guidelines, details of the search strategies used to prepare the material and suggestions for future research ? new Endocrine section. Scott-Brown will provide trainee surgeons (ENT and Head and Neck), audiologists and ENT physicians with quick access to relevant information about clinical conditions, and provide them with a starting point for further research. The accompanying electronic edition, enhanced with operative videos, will enable both easy reference and accessibility on the move.

  • 2385.00 lei



    This volume provides an insight into the future strategies for commercial biocatalysis with a focus on sustainable technologies, together with chemoenzymatic and biotechnological approaches to synthesize various types of approved and new active pharmaceutical ingredients (APIs) via proven and latest synthetic routes using single-step biocatalytic or enzyme cascade reactions. Many of these drugs act as enzyme inhibitors, as discussed in a chapter with a variety of examples. The targeted enzymes are involved in diseases such as different cancers, metastatic and infectious diseases, osteoporosis, and cardiovascular disorders. The biocatalysts employed for API synthesis include hydrolytic enzymes, alcohol dehydrogenases, laccases, imine reductases, reductive aminases, peroxygenases, cytochrome P450 enzymes, polyketide synthases, transaminases, and halogenases. Many of them have been improved with respect to their properties by engineering methods. The book discusses the syntheses of drugs, including alkaloids and antibiotics, non-ribosomal peptides, antimalarial and antidiabetic drugs, prenylated xanthones, antioxidants, and many important (chiral) intermediates required for the synthesis of pharmaceuticals.


    Table of Contents:


    1. Future Strategies for Commercial Biocatalysis

    1.1 Introduction

    1.2 Cascades

    1.2.1 Cell-Free Enzyme Cascades

    1.2.2 Chemoenzymatic Cascades

    1.3 Micro- and Nanoscale Process Design Considerations

    1.3.1 Nanoscale Compartmentalisation

    1.3.2 Microfluidic Reactors

    1.4 Conclusion

    2. Synthetic Approaches to Inhibitors of Isoprenoid Biosynthesis

    2.1 Introduction

    2.2 Bisphosphonates

    2.2.1 Direct Method: Reaction of Carboxylic Derivatives with Phosphorous Reagents

    2.2.2 Indirect Method: Reaction of Acylphosphonates with Dialkyl Phosphites

    2.2.3 Michael Addition to Tetraethyl Vinylidenebisphosphonate

    2.2.4 Alkylation of Tetralkylbisphosphonate

    2.2.5 Other Methods

    2.3 Non-Bisphosphonate Derivative

    2.4 Concluding Remarks

    3. Using a Recombinant Metagenomic Lipase for Enantiomeric Separation of Pharmaceutically Important Drug Intermediates

    3.1 Introduction

    3.2 The Metagenomic Approach

    3.3 Lipases as Biocatalysts

    3.4 Use of Lipases in Drug Synthesis

    3.5 Results

    3.5.1 Metagenomic DNA Isolation and Purification

    3.5.2 Cloning of Lipase (LipR1) Gene from Soil Sample

    3.5.3 Expression and Purification of the LipR1 Protein

    3.5.4 Effect of Temperature

    3.5.5 Effect of pH

    3.5.6 Thermostability Studies

    3.5.7 Effect of Different Additives on Lipase Activity

    3.5.8 Substrate Specificity

    3.5.9 Kinetic Study of the Purified Lipase

    3.5.10 Application of This Lipase for Transesterification Reactions

    3.6 Use of Ionic Liquids

    3.6.1 Reaction with 1-INDANOL

    3.6.2 Reaction with (RS)-3-Benzyloxy-1,2-propanediol

    3.6.3 Reaction with (RS)-α-Methyl-4 Pyridine Methanol

    3.6.4 Reaction with (RS)-α-(Trifluoromethyl) Benzyl Alcohol

    3.6.5 Reaction with 1-(1-Naphthyl) Ethanol

    3.7 Summary

    4. Biotechnological Production of Prenylated Xanthones for Pharmaceutical Use

    4.1 Introduction

    4.2 Biosynthesis of the Core Structure

    4.3 Enzymatic Prenylation of Xanthone Scaffolds in Nature

    4.4 Limitations of Chemical Synthesis

    4.5 Biotechnological Approaches for in vitro Production of Xanthones

    4.5.1 In vitro Cultures

    4.5.2 Cascade Biocatalysis: Learning from Nature

    4.6 Pharmacological Potential: Effect of Pharmacophores on Cytotoxic Activity of Xanthones

    4.6.1 Bioactivities of Chiral Derivatives of Xanthones

    4.7 Conclusions

    5. Chemoenzymatic Approaches towards (S)-Duloxetine

    5.1 Introduction

    5.2 Chemoenzymatic Approaches towards (S)-Duloxetine

    5.3 Stereoselective Resolution Mediated Synthetic Approaches towards (S)-Duloxetine

    5.3.1 Synthesis of (S)-Duloxetine via Immobilized/Mobilized Lipases

    5.3.2 Modified Synthesis of (S)-Duloxetine through Dynamic Kinetic Resolution (DKR)

    5.4 Stereoselective Reduction Mediated Synthetic Approaches towards (S)-Duloxetine

    5.4.1 Synthesis of (S)-Duloxetine via Candida viswanathii

    5.4.2 Synthesis of (S)-Duloxetine through Candida pseudotropicalis

    5.4.3 Application of Rhodotorula glutinis to Synthesize (S)-Duloxetine

    5.4.4 Saccharomyces cerevisiae-Based Synthetic Approach for (S)-Duloxetine

    5.4.5 (S)-Duloxetine Synthesis via Candida tropicalis

    5.4.6 Synthesis of (S)-Duloxetine by Recombinant Aromatoleum aromaticum

    5.4.7 Construction of (S)-Duloxetine Entity via Recombinant Exiguobacterium sp. F42

    5.4.8 Synthesis of (S)-Duloxetine through Recombinant Chryseobacterium sp. CA49

    5.4.9 (S)-Duloxetine Synthesis via Recombinant Rhodosporidium toruloides

    5.4.10 Application of Recombinant Candida albicans to Synthesize (S)-Duloxetine

    5.5 Enantioselective Hydrocyanation Mediated Approaches towards (S)-Duloxetine

    5.5.1 Synthesis of (S)-Duloxetine via Prunus armeniaca

    5.6 Conclusion

    6. Synthesis of Antioxidants via Biocatalysis

    6.1 Introduction

    6.2 What Are Antioxidants?

    6.3 Mechanism of Action

    6.4 Free-Radical Sources and Implications

    6.5 Antioxidants from Biocatalysis

    6.5.1 Pure Enzyme Technology

    6.5.2 Whole-Cell Biotransformation

    6.6 Conclusion

    7. Biocatalysts: The Different Classes and Applications for Synthesis of APIs

    7.1 Introduction

    7.2 Classification of Biocatalysts

    7.3 Biocatalysts: Some General Properties

    7.4 Enzymes: Mechanisms and Applications

    7.4.1 Biocatalysts for Redox Reactions: Mechanisms Applications

    7.4.2 Transaminases: Mechanism and Applications

    7.4.3 Hydrolases: Mechanism and Applications

    7.4.4 Lyases: Aldolases—Mechanism Application in drug design

    7.4.5 Hydroxinitrile Lyases

    7.5 Conclusion

    8. Laccase-Mediated Synthesis of Novel Antibiotics and Amino Acid Derivatives

    8.1 Introduction

    8.2 Laccases as Mediator for Organic Synthesis

    8.3 Enzymatic Transformation of Antibiotics

    8.3.1 Phenolic Oxidative Homodimerization

    8.3.2 Phenolic Oxidative Heterodimerization

    8.3.3 Oxidation Followed by Nuclear Amination para-Dihydroxy aromatic acids and their derivatives aminated by amino-β-lactams ortho-Dihydroxy aromatic acids and their derivatives aminated by amino-β-lactams meta-Dihydroxy aromatics and their reactivity Catechols aminated by amino-β-lactams Alkyl-para-hydroquinones aminated by amino-β-lactams Dihydroxylated aromatics aminated by corollosporines Dihydroxylated aromatics aminated by morpholines Synthesis of mitomycin-like derivatives

    8.3.4 Oxidation Followed by Nuclear Thiolation Catechols thiolated by heterocyclic thiols 1,4-Naphthohydroquinones thiolated by aryl thiols

    8.4 Derivatization of Amino Acids

    8.5 Conclusions

    9. Hydrolytic Enzymes for the Synthesis of Pharmaceuticals

    9.1 Introduction

    9.2 Enzymatic Hydrolytic Reactions for the Synthesis of Pharmaceuticals

    9.2.1 Hydrolysis of Esters and Amino Esters

    9.2.2 Hydrolysis of Amides

    9.2.3 Hydrolysis of Epoxides and Nitriles

    9.3 Design of Synthetic Transformations over Hydrolysis Processes for the Production of Pharmaceuticals

    9.3.1 Esterification of Carboxylic Acids and Acylation of Alcohols and Diols

    9.3.2 Acylation Reactions of Amines

    9.3.3 Alkoxycarbonylation Reactions

    9.4 Conclusions

    10. Ene-Reductases in Pharmaceutical Chemistry

    10.1 Introduction

    10.2 Ene-Reductases: Classification, Substrate Scope, and Reaction Mechanism

    10.3 Biocatalytic Applications

    10.3.1 Enzyme Engineering

    10.3.2 Hydride Sources

    10.3.3 Multienzyme Reactions

    10.4 Industrial Use of Ene-Reductases

    10.4.1 Ene-Reductase Use in the Synthesis of Drugs Profens (2-arylpropanoic acids) Baclofen (β-(4-chlorophenyl)-γ-aminobutyric acid) Pregabalin ((S)-3-(aminomethyl)-5-methylhexanoic acid) Phosphonates Latanoprost

    10.4.2 Ene-Reductase Use in the Synthesis of Building Blocks

    10.5 Conclusion

    11. Biocatalyzed Synthesis of Antidiabetic Drugs

    11.1 Introduction

    11.2 Insulin and Insulin Analogues

    11.3 Amylin Analogues

    11.4 Sensitizers

    11.4.1 PPAR-α Agonists

    11.4.2 Thiazolidinediones (TZDS, Glitazones)

    11.4.3 Glitazars

    11.5 Insulin Secretagogues

    11.6 G Protein-Coupled Receptors Agonists

    11.6.1 Incretin Mimetics

    11.6.2 GPR119 Agonists

    11.7 Enzyme Inhibitors

    11.7.1 Dipeptidyl Peptidase-4 (DPP-4) Inhibitors Sitagliptin Saxagliptin Alogliptin, linagliptin, and trelagliptin Teneligliptin and gosogliptin Other DPP4 inhibitors

    11.7.2 11β-Hydroxysteroid Dehydrogenase type 1 (11β-HSD1) Inhibitors

    11.7.3 α-Glucosidase Inhibitors Iminosugars Carbasugars

    11.8 Glycosurics

    11.9 Conclusions

    12. Glucose-Sensitive Drug Delivery Systems Based on Phenylboronic Acid for Diabetes Treatment

    12.1 Introduction

    12.2 PBA-Mediated LbL Assembles

    12.3 PBA-Regulated Micelles and Vesicles

    12.4 PBA-Functionalized Gels

    12.5 Conclusion

    13. Synthesis of Important Chiral Building Blocks for Pharmaceuticals Using Lactobacillus and Rhodococcus Alcohol Dehydrogenases

    13.1 Introduction

    13.2 Requirements for Lactobacillus and Rhodococcus ADHs as Versatile Enzymes for the Synthesis of Enantiopure Alcohols

    13.3 Alcohols as Chiral Building Blocks Synthesized by Lactobacillus and Rhodococcus ADHs

    13.4 Synthesis of Enantiomerically Pure Alcohols with Lactobacillus and Rhodococcus ADHs in Preparative Scale with 1-Phenylethanol as Example

    13.5 ADHs from Lactobacillus and Rhodococcus Species in Biocatalytic Cascades

    13.6 Searching for New ADHs or Engineering of Well-Known ADHs for Novel Drug Candidates

    13.7 Summary

    14. Asymmetric Reduction of C=N Bonds by Imine Reductases and Reductive Aminases

    14.1 Introduction

    14.1.1 Why Are IREDs Important Tools for Biocatalysis

    14.1.2 Most Acyclic Imines Have a Low Stability in Aqueous Solutions—Reductive Aminases (RedAm) Solve This Problem

    14.1.3 Focus of This Book Chapter

    14.2 Imine Reductions Observed in Nature

    14.2.1 Imine Reductions of Substrates Bearing a Carboxylate Function

    14.2.2 Imine Reductions of Substrates Lacking a Carboxylate Function Alkaloid biosynthesis: IREDs installing an α-chiral amine moiety Alkaloid biosynthesis: IREDs installing a β-chiral amine moiety

    14.2.3 Reductive Aminations Observed in Nature

    14.3 Imine Reductases Explored for Biocatalytical Imine Reduction

    14.3.1 IREDs Belonging to the Hydroxyisobutyrate Dehydrogenases Subfamily

    14.3.2 Imine Reduction with Enzymes Belonging to Other Families or Created by Protein Engineering

    14.3.3 Scope of Biocatalytic Imine Reduction

    14.3.4 Scope of Biocatalytic Reductive Amination: IREDs Require a Large Excess of the Amine Nucleophiles

    14.3.5 Reductive Aminases Allow Usage of Near-Stoichiometric Amounts of Amine Nucleophiles for Selected Substrate Combinations

    14.3.6 Towards the Synthesis of β-Chiral Amines by Dynamic Kinetic Resolution (DKR) of Aldehydes

    14.4 IREDs and RedAms Employed in Cascade Reactions

    14.5 Mechanistic Basis of IREDs and RedAms

    14.5.1 Structural Features of IREDs Important for Imine Reduction

    14.5.2 Mechanistic Differences between Imine Reduction and Reductive Amination

    14.6 Conclusive Remarks

    15. Cipargamin: Biocatalysis in the Discovery and Development of an Antimalarial Drug

    15.1 Introduction

    15.1.1 Biocatalysis at Novartis

    15.1.2 Malaria and Drug Development

    15.2 Biocatalysis in Synthesis of a Drug Candidate

    15.3 Biocatalysis in the Synthesis of Metabolites of Cipargamin (KAE609)

    15.3.1 Biocatalytic Synthesis of M23

    15.4 Biocatalysis in the Synthesis of Cipargamin during Drug Development

    15.4.1 Design of a New Route

    15.4.2 Biocatalysis Using Kinetic Resolutions

    15.4.3 Biocatalysis as a Tool for Asymmetric Synthesis of Chiral Amines Ketone synthesis Transaminase approach Route comparison

    15.5 Conclusion

    16. Halogenases with Potential Applications for the Synthesis of Halogenated Pharmaceuticals

    16.1 Introduction

    16.2 Halogenation Mechanisms

    16.2.1 Electrophilic Mechanism: Haloperoxidases Heme-iron halogenases Vanadium-dependent alogenases Flavin-dependent halogenases

    16.2.2 Radical Mechanism

    16.2.3 Nucleophilic Mechanism

    16.3 Biosynthesis of Halogenated Pharmaceuticals

    16.3.1 Halogenated Pharmaceutical with Antitumor Activity

    16.3.2 Halogenated Pharmaceutical with Antibiotic Activity

    16.3.3 Halogenated Pharmaceutical with Antifungal Activity

    16.4 Perspective

    17. Conversion of Natural Products from Renewable Resources in Pharmaceuticals by Cytochromes P450

    17.1 Introduction

    17.2 Cytochromes P450: General Features

    17.2.1 Nomenclature and Classification

    17.2.2 Catalytic Cycle of Cytochromes P450

    17.3 Cytochromes P450 as Biocatalysts

    17.3.1 Importance of Cytochromes P450 in Biocatalysis

    17.3.2 Natural Products as a Source of Cytochromes P450 Substrates

    17.4 Pharmaceutical Biocatalysis by Cytochromes P450

    17.4.1 Synthesis of Statins

    17.4.2 Synthesis of Active Steroids

    17.4.3 Synthesis of Anticancer Drugs

    17.4.4 Synthesis of Antibiotics, Antifungal, and Antiprotozoal Agents

    17.4.5 Synthesis of New Natural Product–Inspired Drugs Hydroxy fatty acids Phytopharmaceuticals

    17.5 Conclusions and Future Perspectives

    18. Oxyfunctionalization of Pharmaceuticals by Fungal Peroxygenases

    18.1 Introduction

    18.2 Unspecific Peroxygenases

    18.2.1 Properties and Occurrence of Unspecific Peroxygenases

    18.2.2 Catalyzed Reactions and Reaction Mechanism

    18.3 Oxyfunctionalization of Pharmaceuticals

    18.3.1 Oxidation of Aliphatics

    18.3.2 Oxidation of Aromatics and Olefins

    18.3.3 Oxidations Resulting in Cleavage Reactions

    18.4 Conclusion and Outlook

    19. Biocatalytic Synthesis of Chiral 1,2,3,4-Tetrahydroquinolines

    19.1 Introduction

    19.2 Enantiomeric Synthesis of 1,2,3,4-Tetrahydroquinoline-4-ols

    19.3 Enantiomeric Synthesis of 1,2,3,4-Tetrahydroquinolines

    19.4 Conclusion

    20. New Strategies to Discover Non-Ribosomal Peptides as a Source of Antibiotics Molecules

    20.1 Introduction

    20.2 Molecular Mechanism of Antibiotic Resistance

    20.3 Nonribosomal Peptides as a Source of New Antibiotics

    20.4 Genome Mining Strategies to Find NRPs

    20.5 Conclusion

    21. Enzyme Kinetics and Drugs as Enzyme Inhibitors

    21.1 Introduction

    21.2 Enzyme Kinetics

    21.2.1 Michaelis–Menten Equation and the Determination of KM and Vmax

    21.2.2 Inhibition of Enzymes Competitive inhibition Non-competitive inhibition Uncompetitive inhibition Allosteric modulation Covalent (reversible)inhibition: Pros and cons Ki-/IC50-values and the residence-time model

    21.2.3 Enzyme Inhibitors and Activators as Drugs New treatment options for cardiac insufficiency The aldose reductase inhibitor fidarestat enforces chemotherapy Lipid-lowering agents Strategies to combat cancer

    21.3 Concluding Remarks



  • Oral and Maxillofacial Surgery, 3rd Edition
    La comanda in aproximativ 4 saptamani
    2,63200lei 2370.00 lei

    Stay on top of the latest advances, treatments, and best practices with the new third edition of Oral and Maxillofacial Surgery. This trusted, three-volume resource covers the full scope of the field with up-to-date, evidence-based coverage of surgical procedures performed today - including cleft and craniofacial surgeries, oral surgery, oncologic surgery, orthognathic surgery, trauma surgery, surgical pathology, surgery of TMJ disorders, dental implants, dentoalveolar surgery, cosmetic surgery, and reconstructive surgery. More than 4,800 full-color images and illustrations serve as valuable visual references. You’ll also find complete guidelines for a wide range of practice issues such as anesthesia, diagnostic imaging, treatment planning, , psychological considerations, office design and ergonomics, plus new information on implants and orthognathic surgery. It’s all the information you need to perfect your oral and maxillofacial surgical techniques and provide state-of-the-art care for your patients.

    New To This Edition:

    • NEW! Full color design provides a more vivid depiction of pathologies, concepts, and procedures.
    • NEW! Expert Consult website includes all of the chapters from the print text plus "classic" online-only chapters and an expanded image collection, references linked to PubMed, and periodic content updates.
    • NEW! Thoroughly revised and reorganized content reflects current information and advances in OMS.
    • NEW! New chapters on implants and orthognathic surgery cover the two areas where oral and maxillofacial surgeons have been expanding their practice.
    • NEW! Digital formats are offered in addition to the traditional print text and provide on-the-go access via mobile tablets and smart phones.

  • 2305.00 lei



    Written and edited by world-renowned experts in the field, Benzel’s Spine Surgery: Techniques, Complication Avoidance and Management, 5th Edition, provides expert, step-by-step guidance on the evaluation and management of disorders of the spine. This definitive, two-volume work explores the full spectrum of techniques used in spine surgery, giving you the tools you need to hone your skills and increase your knowledge in this challenging area. Clearly organized and extensively revised throughout, it features contributions from both neurosurgeons and orthopaedic surgeons to present a truly comprehensive approach to spine disease.  

    Table Of Contents:

    Part 1: Fundamentals of the Spine 1. History of Spine Surgery 2. History of Spine Biomechanics 3. History of Spinal Instrumentation: The Modern Era 4. Functional Anatomy of the Spine 5. Biomechanical Modeling of the Spine 6. The Intervertebral Disc: Anatomy, Pathophysiology, and Aging 7. Muscles and the Spine: Dynamic Stabilization 8. Bone Physiology and Osteoporosis 9. Applied Anatomy of the Thoracolumbar Spine 10. Fundamentals of Spinal Alignment and Balance 11. Applied Anatomy of the Spinal Cord 12. Molecular and Anatomic Mechanisms of Nerve Root, Spinal Nerve, and Peripheral Nerve Injury 13. Spine Fusion: Biology and Biomechanics 14. Implant Attributes: Cantilever Beam Fixation 15. Biomechanics and Implant Materials: The Anterior Column 16. Biomechanics of Motion Preservation Techniques 17. Complications in Spine Surgery: Expected Rates and Classification Part 2: Pathophysiology of Spinal Disorders Section 2.1: Pathophysiology of Congenital and Developmental Disorders 18. Spinal Cord Dysraphism and Myelodysplasia 19. Congenital Spinal Deformity 20. Early Onset Scoliosis 21. Late-Onset Idiopathic Scoliosis 22. Scheuermann Disease 23. Developmental Spondylolisthesis 24. Craniovertebral Junction Deformities 25. Developmental Deformity in the Cervical Spine 26. Tarlov Cysts 27. Dural and Meningeal Pathologies 28. Chiari Malformations and Syringomyelia Section 2.2: Pathophysiology of Degenerative Disorders 29. Pathophysiology of Cervical Spondylosis, Radiculopathy, and Myelopathy 30. Pathophysiology of Thoracic Spondylosis, Radiculopathy, and Myelopathy 31. Pathophysiology of Intervertebral Disc Degeneration and Pain 32. Deformity in the Cervical Spine 33. Adult Degenerative Scoliosis 34. Lumbar Spondylolisthesis Section 2.3: Pathophysiology of Traumatic Disorders 35. Occipitocervical Injuries 36. Subaxial Cervical Spine Injuries 37. Thoracic and Lumbar Spine Injuries 38. Peripheral Nerve Injury 39. Spinal Cord Injury 40. Spinal Injuries in Sports Section 2.4: Pathophysiology of Inflammatory and Infectious Disorders 41. Rheumatoid Arthritis 42. Ankylosing Spondylitis and Related Disorders 43. Ossification of the Posterior Longitudinal Ligament 44. Primary Infections of the Spine 45. Secondary Infections of the Spine 46. Primary Tumors of the Spine 47. Metastatic Tumors of the Spine 48. Intradural Extramedullary Spine Tumors 49. Intramedullary Spinal Cord Lesions 50. Brachial Plexus Tumors Extending into the Cervicothoracic Spine Section 2.6: Pathophysiology of Syndromic Disorders Affecting the Spine: Connective Tissue and Vascular 51. Spinal Disorders Associated with Connective Tissue Disorders 52. Osteoporosis, Osteomalacia, and Metabolic Bone Disease 53. Vascular Malformations of the Spine 54. Neuromuscular Disorders in the Pediatric Spine 55. Neurodegenerative Disorders in the Adult Spine Section 2.7: Pathophysiology of Postoperative Spinal Disorders 56. Postoperative Spinal Disorders - Cervical 57. Postoperative Spinal Deformity 58. Adjacent Segment Degeneration and Disease of the Cervical Spine 59. Adjacent Segment Degeneration and Disease of the Lumbar Spine 60. Proximal and Distal Junctional Kyphosis and Failure Part 3: Evaluation of Patients with Spinal Disorders 61. Physical and Neurologic Examination 62. Sagittal Spinal Alignment: An Evolutionary Perspective 63. Spinal Alignment: Significance and Preoperative Planning 64. Overview of Imaging Procedures Available for Spinal Diagnosis 65. Electrodiagnostic Studies 66. Differential Diagnosis of Surgical Disorders of the Spine 67. Patient Selection for Spine Surgery: Preoperative Optimization 68. Evaluation of the Aging Patient 69. Preoperative Evaluation of Psychosocial Aspects and Work-related Issues 70. Preoperative Evaluation of Patients with Tumors Affecting the Spine 71. Measuring Preoperative Health-Related Quality of Life: What Metrics Matter Part 4: Management of Spinal Disorders Section 4.1: Nonoperative Approaches 72. Rehabilitation, Interventions, and Medications in Management of Spinal Disorders 73. Spine Injections 74. Cognitive Behavioral Therapy and Back Pain 75. Regenerative Strategies and the Intervertebral Disc Degeneration 76. Neuromodulation and Rehabilitative Interventions for the Spine 77. Pain Management: Opioids and Alternatives Section 4.2: Operative Management of Spinal Disorders: Overview and Principles 78. Fundamentals of Spine Surgery 79. Perioperative Management Protocols: Enhanced Recovery After Surgery (ERAS) 80. Surgical Incisions, Positioning, and Retraction 81. Intraoperative Imaging Protocols 82. Anesthesia for Spine Surgery and the Prevention of Complications 83. Intraoperative Monitoring in Routine and Complex Surgery 84. Blood Management and Complex Spine Surgery 85. Intraoperative Crisis Management in Spine Surgery: What to Do When Things Go Bad 86. Biologics in Spine Fusion Surgery 87. Osteointegration: The Bone and Implant Interface 88. Common Complications in Spine Surgery: Pseudarthrosis 89. Postoperative Medical Complications 90. Preventing Postoperative Infections: An Evidence-Based Approach 91. Neurologic Complications of Common Spine Operations 92. Cerebrospinal Fluid Leak: Repair and Outcomes 93. Arachnoiditis 94. Arachnoiditis and Syringomyelia 95. Posttraumatic and Idiopathic Syringomyelia 96. Vascular and Soft Tissue Complications 97. Postoperative Spinal Deformities 98. Implant Wear, Degradation, and Breakage 99. Spine Readmissions and Reoperations Section 4.3: Operative Management of Spinal Disoders: Occipital and Cervical 100. Cervical Spine Construct Design 101. Occipitocervical Spine Approaches for Decompression 102. Occipitocervical Spine Posterior Approaches for Fusion 103. Endoscopic and Transnasal Approaches to the Craniocervical Junction 104. Cervical Spine and Cervicothoracic Junction - Posterior 105. Posterior Cervical Decompressions: Cervical Laminectomy and Laminoforaminotomy 106. Cervical Laminoplasty 107. Dorsal Subaxial Cervical Instrumentation Techniques 108. Posterior Percutaneous and Minimally Invasive Approaches to Decompression and Arthrodesis of the Cervical Spine 109. Cervical Spine and Cervicothoracic Junction - Anterior Approach 110. Anterior Cervical Discectomy and Corpectomy 111. Management of Soft Cervical Disc Herniation: Controversies and Complication Avoidance 112. Anterior Sub-Axial Cervical Fixation and Fusion Techniques 113. Cervical Total Disc Arthroplasty 114. Combined Ventral-Dorsal Surgery Section 4.4: Operative Management of Spinal Disorders: Thoracolumbar 115. Thoracic and Lumbar Spine Construct Design 116. Posterior Approaches to the Thoracic Spine 117. Anterior Approaches and Lateral Approaches to the Thoracic Spine 118. MIS Lateral Thoracic Decompression 119. Thoracoscopic Corpectomy and Reconstruction 120. Posterolateral Thoracolumbar Fusion 121. Posterior Thoracic and Lumbar Universal Spinal Instrumentation 122. Midline Lumbar Interbody Fusion with Cortical Bone Trajectory Pedicle Screw Placement 123. Transforaminal Lumbar Interbody Fusion 124. Dorsal Semi-Rigid Stabilization 125. Lumbar Total Disc Arthroplasty 126. Minimally Invasive Spinal Decompression and Stabilization Techniques I: Philosophy and Rationale 127. Posterior Approaches to the Lumbar Spine: Minimally Invasive Decompression 128. Endoscopic Approaches to the Cervical Spine 129. Endoscopic Surgical Approaches to the Lumbar Spine 130. Posterior Approaches to the Lumbar Spine: Minimally Invasive Fusion 131. Anterior Lumbar Interbody Fusion 132. Anterior and Anterolateral Lumbar Spine Decompression and Fusion: MIS Approaches 133. Complex Lumbosacropelvic Fixation Techniques 134. Spinal Augmentation for Vertebral Compression Fractures Part 5: Operative Management of Specific Disorders of the Spine Section 5.1: Degenerative Pathologies 135. Indications for Spine Fusion for Axial Pain 136. Cervical Disc Herniation 137. Lumbar Intervertebral Disc Herniation 138. Thoracic Discectomy 139. Degenerative Spondylolisthesis 140. Sacroiliac Joint Pain Section 5.2: Spinal Deformity 141. Surgical Principles for Spinal Deformity 142. An Approach for Treatment of Complex Adult Spinal Deformity 143. An Approach for Treatment of Complex Pediatric Spinal Deformity 144. Cervicothoracic Deformity: The Role of Anterior Surgery 145. Cervical and Cervicothoracic Deformity Correction: Posterior-based Osteotomies 146. The Role of Anterior Surgery for Thoracolumbar Deformity 147. Anterior Column Release in Deformity. 148. Posterior-based Management of Spinal Deformity 149. Minimally Invasive Approaches to Spinal Deformity 150. Surgical Management of High-Grade Dysplastic Spondylolisthesis 151. Deformity Surgery for Ankylosing Spondylitis 152. Failed Back Surgery Syndrome Section 5.3: Tumors of the Spine 153. Oncologic Approaches, and Outcomes for Primary Spine Tumors 154. Staging, Classification, and Oncologic Approaches for Metastatic Tumors Involving the Spine 155. Tumors at the Foramen Magnum and Craniocervical Junction 156. Cervicothoracic Junction Tumors 157. Thoracic and Thoracolumbar Spinal Tumors: Regional Challenges 158. Sacral Tumors: Regional Challenges 159. Radiosurgery for Spinal Tumors Section 5.4: Trauma and the Spine 160. The Acute Management of Traumatic Spinal Cord Injury and Polytrauma 161. Timing of Surgery Following Spinal Cord Injury 162. Medical Management of Adult and Pediatric Spinal Cord Injury 163. Spinal Traction 164. Medical Management of Fractures without Spinal Cord Injury 165. Anterior Surgery for Cervical Trauma 166. Posterior Surgery for Cervical Trauma 167. Surgical Approaches to Thoracolumbar Trauma 168. Surgical Approaches for Sacral Fractures and Sacropelvic Injuries 169. Rehabilitation and Recovery after Spinal Cord Injury Section 5.5: General Surgical Technique 170. Harvest of Autograft for Spinal Fusion 171. Vascularized Bone Grafts in Spine Surgery 172. Spinal Wound Closure Part 6: Evidence Development and Guidance of Informed Choice for Optimal Outcomes 173. Big Data in Health Care 174. Spine Registries 175. Conflicts of Interest in Spine Surgery 176. Art of the Clinical Trial 177. Meaningful Retrospective Analysis 178. Art and Science of Guideline Formation 179. Appropriate Use Criteria in Spine Surgery 180. Precision Medicine: Artificial Intelligence Applied to Evaluation and Management of Spinal Disorders 181. Healthcare Reform and Spine Surgery 182. Development of New Technologies in Spine Surgery


  • Art of Laparoscopic Surgery; Textbook and Atlas
    La comanda in aproximativ 4 saptamani
    2,70000lei 2300.00 lei

    This second edition discusses information pertaining to various minimal access surgeries. This edition is divided into four distinct volumes: basic laparoscopic surgery, esophagogastric surgery, colorectal surgery. and hepato-pancreato-biliary surgery. Each chapter includes detailed operative description and images in the form of atlas. The book illustrates advanced laparoscopic techniques and step-by-step information of operative procedures. It will assist in our understanding of current concepts of laparoscopic surgery and the technical details. Thoroughly revised edition including requisite advanced laparoscopic techniques with step-by-step description of the operative procedure and adequate number of high quality intraoperative pictures. Volume 1: Basic Laparoscopic Surgery provides a detailed description to give an overall view about the various basic aspects of laparoscopic surgery, the instrumentation, energy devices, training modules operation theatre staff nurse training and laparoscopic operation setup. This volume will be helpful to various minimally invasive surgeons in all the fields like General surgeons, Gastrointestinal surgeons, Urology surgeons, Surgical oncologists and Gynecologists. Volume 2: Esophagogastric Surgery includes detailed descriptions of the diseases of the oesophagus and stomach ranging from benign diseases to malignancies. Oesophageal and stomach cancer, particularly thoracoscopic esophagectomy in prone technique Ivor Lewis two stage esophagectomy and D2 radical gastrectomy, have been described in detail. Volume 3: Colorectal Surgery includes detailed descriptions of various minimally-invasive colorectal procedures involving the most recent approaches, such as minimally-invasive inter sphincteric resection for low rectal malignancies. Colon cancer, including transverse colon and rectum, prolapse rectum, total proctocolectomy with ileoanal pouch anastomosis, has been described in detail. Volume 4: Hepato-Pancreato-Biliary Surgery describes in detail all the minimally-invasive hepatobiliary surgeries. The World first laparoscopic Whipple's operation has been described, along with guidelines and selection for laparoscopy derived in the first international summit on laparoscopic pancreatic resection. A chapter on laparoscopic donor hepatectomy is also included in the book. This book has been well-accepted by the surgical fraternity and has also got translated into other languages like Spanish, Korean and Chinese.

  • 2,53000lei 2300.00 lei



    Schmidek and Sweet has been an indispensable reference for neurosurgery training and practice for nearly 50 years, and the 7th Edition of Operative Neurosurgical Techniques continues this tradition of excellence. A new editorial board led by editor-in-chief Dr. Alfredo Quinones-Hinojosa, along with more than 330 internationally acclaimed contributors, ensures that readers stay fully up to date with rapid changes in the field. New chapters, surgical videos, and quick-reference features throughout make this edition a must-have resource for expert procedural guidance for today’s practitioners.  

    Table Of Contents:

    Volume One

    1. Ensuring Patient Safety in Surgery-First Do No Harm
    2. Surgical Navigation with Intraoperative Imaging: Special Operating Room Concepts

    Section One

    Surgical Management of Brain and Skull Base Tumors

    Intra-Axial Brain Tumors

    1. Functional Tractography, Diffusion Tensor Imaging, Intraoperative Integration of Modalities, and Neuronavigation
    2. Intraoperative Neurophysiology: A Tool to Prevent and/or Document Intraoperative Injury to the Nervous System
    3. Gamma Knife Surgery for Cerebral Vascular Malformations and Tumors
    4. Cortical and Subcortical Brain Mapping
    5. Chemotherapy for Brain Tumors
    6. Current Surgical Management of High-Grade Gliomas
    7. Surgical Management of Low-Grade Gliomas
    8. Management of Recurrent Gliomas
    9. Tumors in Eloquent Areas of Brain
    10. Management of Primary Central Nervous System Lymphomas
    11. Surgical Management of Brain Stem Tumors in Adults
    12. Cerebellar Tumors in Adults
    13. Surgical Management of Cerebral Metastases

    Pituitary and Parapituitary Tumors

    1. Multimodal Assessment of Pituitary and Parasellar Lesions
    2. Medical Management of Hormone-Secreting Pituitary Tumors
    3. Growth Hormone-Secreting Tumors
    4. Prolactinomas
    5. Cushing?s Disease
    6. Endocrinologically Silent Pituitary Tumors
    7. Endoscopic Endonasal Pituitary and Skull Base Surgery
    8. Transcranial Surgery for Pituitary Macroadenomas
    9. Craniopharyngiomas
    10. Endoscopic Endonasal Approach for Craniopharyngiomas
    11. Arachnoid, Suprasellar, and Rathke?s Cleft Cysts

    Intraventricular Tumors

    1. Surgical Approaches to Lateral and Third Ventricular Tumors
    2. Transcallosal Surgery of Lesions Affecting the Third Ventricle: Basic Principles
    3. Endoscopic Approach to Intraventricular Brain Tumors
    4. Management of Pineal Region Tumors
    5. Management of Tumors of the Fourth Ventricle

    Extra-Axial and Posterior Tumors

    1. Surgical Management of Parasagittal and Convexity Meningiomas
    2. Surgical Approach to Falcine Meningiomas
    3. Surgical Management of Midline Anterior Skull Base Meningiomas
    4. Supraorbital Approach Variants for Intracranial Tumors
    5. Surgical Management of Sphenoid Wing Meningiomas
    6. Spheno-Orbital Meningioma
    7. Tumors Involving the Cavernous Sinus
    8. Surgery for Trigeminal Neurinomas
    9. Surgical Management of Petroclival Meningiomas
    10. Surgical Management of Lesions of the Clivus
    11. Surgical Management of Posterior Fossa Meningiomas
    12. Surgical Management of Tumors of the Foramen Magnum
    13. Surgical Management of Tumors of the Jugular Foramen

    Cerebellopontine Angle Tumors

    1. Suboccipital Retrosigmoid Surgical Approach for Vestibular Schwannoma (Acoustic Neuroma)
    2. Translabyrinthine Approach to Vestibular Schwannomas
    3. Transtemporal Approaches to Posterior Cranial Fossa
    4. Surgical Management of Neurofibromatosis Types 1 and 2
    5. Hearing Prosthetics: Surgical Techniques

    Lesions at the Skull Base

    1. Multimodal Treatment of Orbital Tumors
    2. Surgical Approaches to the Orbit603
    3. Anterior Midline Approaches to the Skull Base
    4. Orbitozygomatic Infratemporal Approach to Parasellar Meningiomas

    Section Two

    Operative Techniques in Pediatric Neurosurgery

    1. Methods for Cerebrospinal Fluid Diversion in Pediatric Hydrocephalus: From Shunt to Scope
    2. Posterior Fossa Tumors in the Pediatric Population: Multidisciplinary Management
    3. Supratentorial Tumors in the Pediatric Population: Multidisciplinary Management
    4. Mapping, Disconnection, and Resective Surgery in Pediatric Epilepsy
    5. Surgical Decision-Making and Treatment Options for Chiari Malformations in Children
    6. Fetal Surgery for Open Neural Tube Defects
    7. Surgical Management of Spinal Dysraphism
    8. Revascularization Techniques in Pediatric Cerebrovascular Disorders
    9. Management of Pediatric Severe Traumatic Brain Injury
    10. Contemporary Dorsal Rhizotomy Surgery for the Treatment of Spasticity in Childhood
    11. Instrumentation and Stabilization of the Pediatric Spine: Technical Nuances and Age-Specific Considerations
    12. Methods of Cranial Vault Reconstruction for Craniosynostosis

    Section Three

    Vascular Diseases

    Open Treatment

    1. Surgical Management of the Extracranial Carotid Artery Disease
    2. Management of Dissections of the Carotid and Vertebral Arteries
    3. Management of Unruptured Intracranial Aneurysms
    4. Surgical Management of Intracerebral Hemorrhage
    5. Surgical Management of Cerebellar Stroke-Hemorrhage and Infarction
    6. Surgical Treatment of Moyamoya Disease in Adults
    7. Surgical Treatment of Paraclinoid Aneurysms
    8. Surgical Management of Posterior Communicating, Anterior Choroidal, Carotid Bifurcation Aneurysms
    9. Surgical Management of Anterior Communicating and Anterior Cerebral Artery Aneurysms
    10. Surgical Management of Aneurysms of the Middle Cerebral Artery
    11. Surgical Management of Terminal Basilar and Posterior Cerebral Artery Aneurysms
    12. Surgical Management of Midbasilar and Lower Basilar Aneurysms
    13. Surgical Management of Aneurysms of the Vertebral and Posterior Inferior Cerebellar Artery CompleX
    14. Far Lateral Approach and Transcondylar and Supracondylar Extensions for Aneurysms of the Vertebrobasilar Junction
    15. Surgical Management of Cranial Dural Arteriovenous Fistulas
    16. Surgical Management of Cavernous Malformations of the Nervous System
    17. Surgical Management of Infratentorial Arteriovenous Malformations
    18. Surgical Management of Cerebral Arteriovenous Malformations

    Endovascular Treatment

    1. Endovascular Management of Intracranial Aneurysms1019
    2. Endovascular Treatment of Stroke
    3. Endovascular Treatment of Cerebral Arteriovenous Malformations
    4. Endovascular Treatment of Intracranial Occlusive Disease
    5. Endovascular Treatment of Extracranial Occlusive Disease
    6. Embolization of Tumors: Brain, Head, Neck, and Spine
    7. Endovascular Management of Dural Arteriovenous Fistulas
    8. Endovascular Management of Spinal Vascular Malformations
    9. Endovascular Treatment of Head and Neck Bleeding
    10. Imaging Evaluation and Endovascular Treatment of Vasospasm

    Section Four


    1. Surgical Management of Hydrocephalus in the Adult
    2. Adult Pseudotumor Cerebri Syndrome
    3. Endoscopic Third Ventriculostomy
    4. Management of Shunt Infections

    Section Five

    Stereotactic Radiosurgery

    1. Interstitial and LINAC-Radiosurgery for Brain Metastases
    2. Stereotactic Radiosurgery for Trigeminal Neuralgia
    3. CyberKnife Radiosurgery for Spinal Neoplasms
    4. Stereotactic Radiosurgery for Pituitary Adenomas
    5. Radiation Therapy and Radiosurgery in the Management of Craniopharyngiomas
    6. Vestibular Schwannomas: The Role of Stereotactic Radiosurgery
    7. Stereotactic Radiosurgery Meningiomas
    8. Role of Gamma Knife Radiosurgery in the Management of Arteriovenous Malformations
    9. Radiation Therapy of Epilepsy
    10. Gamma Surgery for Functional Disorders

    Volume Two
    Section Six: Functional Neurosurgery

    Surgical Management of Medically Intractable Epilepsy

    1. Presurgical Evaluation for Epilepsy Including Intracranial Electrodes
    2. Temporal Lobe Operations in Intractable Epilepsy
    3. Surgical Management of Extratemporal Lobe Epilepsy
    4. Multilobar Resection and Hemispherectomy in Epilepsy Surgery
    5. Corpus Callosotomy: Indications and Techniques
    6. Treatment of Intractable Epilepsy by Electrical Stimulation of the Vagus Nerve

    Surgical Management of Psychiatric and Movement Disorders

    1. Deep Brain Stimulation in Movement Disorders: Parkinson?s Disease, Essential Tremor, and Dystonia
    2. Cervical Dystonia and Spasmodic Torticollis: Indications and Techniques
    3. Novel Targets in Deep Brain Stimulation for Movement Disorders
    4. Molecular Therapies for Movement Disorders
    5. Cingulotomy for Intractable Psychiatric Illness
    6. Deep Brain Stimulation for Intractable Psychiatric Illness
    7. Brain-Computer Interfacing Prospects and Technical Aspects
    8. Thoracoscopic Sympathectomy for Hyperhidrosis
    9. Surgery for Intractable Spasticity

    Surgical Management of Intractable Pain

    1. Retrogasserian Glycerol Rhizolysis in Trigeminal Neuralgia
    2. Percutaneous Stereotactic Rhizotomy in the Treatment of Intractable Facial Pain
    3. Neurovascular Decompression in Cranial Nerves V, VII, IX, and X
    4. Deep Brain Stimulation for Pain
    5. Mesencephalic Tractotomy and Anterolateral Cordotomy for Intractable Pain
    6. Spinal Cord Stimulation for Chronic Pain
    7. Spinal Cord Stimulation and Intraspinal Infusions for Pain
    8. Dorsal Root Entry Zone Lesions
    9. Motor Cortex Stimulation for Intractable Facial Pain

    Section Seven


    1. Perioperative Management of Severe Traumatic Brain Injury in Adults
    2. Surgical Management of Severe Closed Head Injury in Adults
    3. Management of Penetrating and Blast Injuries of the Nervous System
    4. Decompressive Craniectomy for Traumatic Brain Injury
    5. Management of Skull Base Trauma
    6. Surgical Management of Chronic Subdural Hematoma in Adults
    7. Management of Cerebrospinal Fluid Leaks
    8. Principles of Scalp Surgery and Surgical Management of Major Defects of Scalp
    9. Surgical Management of Major Skull Defects and Potential Complications
    10. Management of Traumatic Intracranial Aneurysms
    11. Management of Penetrating Brain Injury

    Section Eight

    Surgical Management of Nervous System Infections

    1. Management of Suppurative Intracranial Infections
    2. Management of Infections After Craniotomy
    3. Spinal Infections: Vertebral Osteomyelitis and Spinal Epidural Abscess
    4. Neurosurgical Management of HIV-Related Focal Brain Lesions
    5. Management of Neurocysticercosis
    6. Management of Tuberculous Infections of the Nervous System
    7. Fungal Infections of the Central Nervous System
    8. Management of Intracranial Aneurysms Caused by Infection

    Section Nine: Neurosurgical Management of Spinal Disorders

    Degenerative Spine Disorder

    Cervical Spine

    1. Treatment Evolution in Management of Cervical Disc Disease
    2. Anterior Cervical Foraminotomy (Jho Procedure): Microscopic or Endoscopic
    3. Minimally Invasive Posterior Cervical Foraminotomy and Microdiscectomy
    4. Disc Replacement Technologies in the Cervical and Lumbar Spine
    5. Anterior Approaches for Multilevel Cervical Spondylosis
    6. Management of Cervical Spondylotic Myelopathy
    7. Cervical Laminoplasty: Indications and Techniques
    8. Circumferential Cervical Spinal Fusion

    Thoracic Spine

    1. Surgical Techniques in the Management of Thoracic Disc Herniations
    2. Video-Assisted Thoracoscopic Discectomy: Indications and Techniques

    Lumbar Spine

    1. Lumbar Microdiscectomy: Indications and Techniques
    2. Minimally Invasive Lumbar Microdiscectomy: Indications and Techniques
    3. Management of Far Lateral Lumbar Disc Herniations
    4. Lumbar Spinal Arthroplasty: Clinical Experiences of Motion Preservation
    5. Management of Degenerative Lumbar Stenosis and Spondylolisthesis
    6. Posterior Lumbar Fusion by Open Technique: Indications and Techniques
    7. Percutaneous Placement of Lumbar Pedicle Screws: Indications and Techniques
    8. Dynamic Stabilization of the Lumbar Spine: Indications and Techniques
    9. Posterior Lumbar Interbody Fusion
    10. Transforaminal Lumbar Interbody Fusion: Indications and Techniques
    11. Anterior Lumbar Interbody Fusion: Indications and Techniques
    12. Lateral Lumbar Interbody Fusion: Indications and Techniques
    13. Vertebroplasty and Kyphoplasty: Indications and Techniques

    Spine Trauma

    1. Management of Injuries of the Cervical Spine and Spinal Cord
    2. Transoral Approaches to the Cervical Spine
    3. Atlantoaxial Instability and Stabilization
    4. Stabilization of the Subaxial Cervical Spine (C3-C7)
    5. Thoracolumbar Anterolateral and Posterior Stabilization
    6. Management of Sacral Fractures
    7. Management of Penetrating Injuries to the Spine

    Congenital and Developmental Spinal Abnormalities

    1. Craniovertebral Abnormalities and Their Neurosurgical Management
    2. Management of Chiari Malformations and Syringomyelia
    3. Management of Occult Spinal Dysraphism in Adults
    4. Neurologic Problems of the Spine in Achondroplasia

    Spinal Deformity

    1. Management of Degenerative Scoliosis

    Spine Tumors

    1. Surgical Management of Intramedullary Spinal Cord Tumors in Adults
    2. Intradural Extramedullary Tumors
    3. Management of Spinal Cord Tumors and Arteriovenous Malformations
    4. Management of Cauda Equina Tumors
    5. Management of Primary Malignant Tumors of the Osseous Spine
    6. Surgical Approaches to the Cervicothoracic Junction
    7. Surgery for Metastatic Spine Disease
    8. Surgical Resection of Sacral Tumors

    Specific Complications of Spine Surgery

    1. Surgical Management of Cerebrospinal Fluid Leakage after Spinal Surgery

    Section Ten: Surgical Management of the Peripheral Nervous System

    1. Peripheral Nerve Injury
    2. Imaging for Peripheral Nerve Disorders
    3. Management of Adult Brachial Plexus Injuries
    4. Nerve Transfers: Indications and Techniques
    5. Management of Median Nerve Compression
    6. Management of Ulnar Nerve Compression
    7. Management of Entrapment Neuropathies
    8. Management of Nerve Sheath Tumors Involving the Spine
    9. Peripheral Nerve Tumors of the Extremities
    10. Management of Cranial Nerve Injuries
    11. Management of Thoracic Outlet Syndrome
    12. Nerve-Grafting Procedures for Birth-Related Peripheral Nerve Injuries

  • 2,64000lei 2300.00 lei

    Silverberg's Principles and Practice of Surgical Pathology and Cytopathology is one of the most durable reference texts in pathology. Thoroughly revised and updated, this state-of-the-art new edition encompasses the entire fields of surgical pathology and cytopathology in a single source. Its practice-oriented format uniquely integrates these disciplines to present all the relevant features of a particular lesion, side by side. Over 4000 color images depict clinical features, morphological attributes, histochemical and immunohistochemical findings, and molecular characteristics of all lesions included. This edition features new highly experienced and academically accomplished editors, while chapters are written by the leading experts in the field (several new to this edition, bringing a fresh approach). Dr Steven Silverberg's practical approach to problem solving has been carefully preserved. The print book is packaged with access to a secure, electronic copy of the book, providing quick and easy access to its wealth of text and images.

  • 2200.00 lei

    The AO Principles of Fracture Management has served many generations of surgeons around the world as the source of knowledge and essential reference in the field of orthopedic trauma surgery. The fundamental principles of fracture surgery have not changed in 60 years, but the biological and clinical knowledge, as well as technological advancements have extended new possibilities in surgical treatment and offered surgeons the opportunity to explore new ways of applying the AO principles.

    The new third edition of this book has been expanded to include new knowledge and explore state-of-the-art technology. It also addresses pressing challenges that face orthopedic surgeons today, such as the exponential rise in fragility fractures resulting from demographic changes and an aging population. The book aims to help surgeons to successfully rise to such challenges.

    Key features include:

    • Contributions from more than 50 highly renowned surgeons, scientists, and medical professionals
    • More than 2,100 high-quality illustrations and images, as well as access to over 250 video presentations
    • New chapters on periprosthetic fractures, knee dislocations, fragility fractures and orthogeriatric care and additional information on operating room setup and planning
    • Immediate access to AO's continually evolving range of online educational offerings via QR codes for mobile devices including animations, webcasts, webinars, lectures, AO Surgery Reference, AOSTART and more

    AOTrauma is pleased to bring you a new expanded, comprehensive, and updated edition of the AO Principles of Fracture Management for residents, fellows, course participants and faculty, Trauma and Orthopedic surgeons, and operating room personnel.

  • 2195.00 lei

    This book is a comprehensive guide to vascular imaging and endovascular interventions. Divided into fifteen sections, the first chapters provide an overview of vascular imaging, radiation safety, contrast agents and pharmacologics. The following sections cover vascular anatomy, pathology and non-invasive vascular imaging, with each topic further divided by anatomical region. The text continues with detail on angiographic techniques, then each of the following sections provides in depth information on the diagnosis and treatment of different vascular diseases. The book concludes with discussion on male and female genitoreproductive diagnosis and interventions. Written by internationally recognised authorities in the field, this book is highly illustrated with clinical images and diagrams. Key Points Comprehensive guide to vascular imaging and endovascular interventions Provides overview of vascular imaging, radiation safety, contrast agents and pharmacologics Covers diagnosis and treatment of numerous vascular disorders Internationally recognised author team

  • 2,66800lei 2180.00 lei

     Greenfield's Neuropathology, the world’s leading neuropathology reference, provides a comprehensive account of the pathological findings in neurological disease, their biological basis, and their clinical manifestations.

    The book’s detailed advice on pathological assessment and interpretation is based on clear descriptions of molecular and cellular processes and reactions that are relevant to the development of the nervous system, as well as its normal and abnormal functioning. The information is presented in an accessible way to readers working within a range of disciplines in the clinical neurosciences, and neuropathological findings are placed within the context of a broader diagnostic process.

    New for the Ninth Edition:

    Features online and downloadable digital formats with rapid search functions, annotation and bookmarking facilities, image collections, and live reference links

    Contains many color illustrations and high-quality clinical photographs to help with interpretation and understanding

    Includes more than 1000 new photographs and drawings

    Incorporates new design elements, such as alternate colour coding of chapters for easier navigation

    Known for its thorough yet practical approach, Greenfield's continues to provide trusted information to all neuropathologists and those in related specialties, including neurologists, neurosurgeons, general pathologists, neuroradiologists, and clinical neuroscientists.

  • 2,58800lei 2150.00 lei

    2788 RON 2300 RON

    This title is a compendium of nearly every procedure performed in orthopaedic surgery. The relevant trauma or pathophysiology is explained briefly, as a necessary adjunct to what to do to correct it. The presentation is templated and extremely rich in graphics for easy reading and retention. Coverage is comprehensive, including all joints as well as sports medicine, pediatrics, orthopaedic oncology, and spine.

    Key Features:

    • Find highly illustrated, expert guidance for virtually any orthopaedic procedure you’re likely to perform.
    • Stay up to date with the most current procedures – more than 50 procedures are new to this edition!
    • Quickly review the relevant trauma or pathophysiology before viewing step-by-step coverage of the procedure.
    • Easily locate and remember information thanks to bullet points, a highly templated format, and a graphic-rich presentation.
    • Get easy-to-follow details on orthopaedic procedures involving all joints, as well as sports medicine, pediatrics, the spine, and orthopaedic oncology.
    • Benefit from a consistent approach to each procedure that makes reference quick and easy: definition, anatomy, physical exams, pathogenesis, natural history, physical findings, imaging and diagnostic studies, differential diagnosis, non-operative management, surgical management, perils and pitfalls, postoperative care, outcomes, and complications.
    • Access an updated web-based version, now featuring easier navigation and search capabilities. Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like:
    • Complete content with enhanced navigation

  • 2,43600lei 2100.00 lei


    From the basic science underpinnings to the most recent developments in medical and surgical care, Campbell-Walsh-Wein Urology offers a depth and breadth of coverage you won’t find in any other urology reference. Now in three manageable volumes, the revised 12th Edition is a must-have text for students, residents, and seasoned practitioners, with authoritative, up-to-date content in an intuitively organized, easy-to-read format featuring key points, quick-reference tables, and handy algorithms throughout.

    Key Features:

    • Features shorter, more practical chapters that help you find key information quickly.
    • Includes new chapters on Urinary Tract Imaging: Basic Principles of Nuclear Medicine · Ethics and Informed Consent · Incisions and Access · Complications of Urologic Surgery · Urologic Considerations in Pregnancy · Intraoperative Consultation · Special Urologic Considerations in Transgender Individuals · and more.
    • Covers hot topics such as minimally invasive and robotic surgery; advancements in urologic oncology, including innovative therapeutics for personalized medicine; new approaches to male infertility; technological advances for the treatment of stones; and advances in imaging modalities.
    • Incorporates current AUA/EAU guidelines in each chapter as appropriate
    • Updates all chapters with new content, new advances, and current references and best practices. Extensively updated chapters include Urological Immunotherapy, Minimally Invasive Urinary Diversion, and Updated Focal Therapy for Prostate Cancer.
    • Features more than 175 video clips, including all-new videos on perineal ultrasound, abdominoplasty in prune belly syndrome, partial penectomy, low dose rate brachytherapy, and many more.
    • Written and edited by key opinion leaders, reflecting essential changes and controversies in the field.
    • Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.


    Table of Contents:


    Chapter 1: Evaluation of the Urologic Patient: History and Physical Examination


    Chapter 2: Evaluation of the Urologic Patient: Testing and Imaging


    Chapter 3: Urinary Tract Imaging: Basic Principles of CT, MRI, and Plain Film Imaging


    Chapter 4: Urinary Tract Imaging: Basic Principles of Urologic Ultrasonography


    Chapter 5: Urinary Tract Imaging: Basic Principles of Nuclear Medicine


    Chapter 6: Assessment of Urologic and Surgical Outcomes


    Chapter 7: Ethics and Informed Consent


    Chapter 8: Principles of Urologic Surgery: Perioperative Care


    Chapter 9: Principles of Urologic Surgery: Incisions and Access


    Chapter 10: Principles of Urologic Surgery: Intraoperative Technical Decisions


    Chapter 11: Lower Urinary Tract Catheterization


    Chapter 12: Fundamentals of Upper Urinary Tract Drainage


    Chapter 13: Principles of Urologic Endoscopy


    Chapter 14: Fundamentals of Laparoscopic and Robotic Urologic Surgery


    Chapter 15: Basic Energy Modalities in Urologic Surgery


    Chapter 16: Evaluation and Management of Hematuria


    Chapter 17: Complications of Urologic Surgery


    Chapter 18: Urologic Considerations in Pregnancy


    Chapter 19: Intraoperative Consultation


    Chapter 20: Embryology of the Genitourinary Tract


    Chapter 21: Urologic Aspects of Pediatric Nephrology


    Chapter 22: Perinatal Urology


    Chapter 23: Urologic Evaluation of the Child


    Chapter 24: Pediatric Urogenital Imaging


    Chapter 25: Infection and Inflammation of the Pediatric Genitourinary Tract


    Chapter 26: Core Principles of Perioperative Management in Children


    Chapter 27: Principles of Laparoscopic and Robotic Surgery in Children


    Chapter 28: Clinical and Urodynamic Evaluation of Lower Urinary Tract Dysfunction in Children


    Chapter 29: Management Strategies for Vesicoureteral Reflux


    Chapter 30: Bladder Anomalies in Children


    Chapter 31: Exstrophy-Epispadias Complex


    Chapter 32: Prune-Belly Syndrome


    Chapter 33: Posterior Urethral Valves


    Chapter 34: Neuromuscular Dysfunction of the Lower Urinary Tract in Children


    Chapter 35: Functional Disorders of the Lower Urinary Tract in Children


    Chapter 36: Management of Defecation Disorders


    Chapter 37: Lower Urinary Tract Reconstruction in Children


    Chapter 38: Anomalies of the Upper Urinary Tract


    Chapter 39: Renal Dysgenesis and Cystic Disease of the Kidney


    Chapter 40: Pathophysiology of Urinary Tract Obstruction


    Chapter 41: Ectopic Ureter, Ureterocele, and Ureteral Anomalies


    Chapter 42: Surgery of the Ureter in Children: Ureteropelvic Junction, Megaureter, and Vesicoureteral Reflux


    Chapter 43: Management of Pediatric Kidney Stone Disease


    Chapter 44: Management of Abnormalities of the External Genitalia in Boys


    Chapter 45: Hypospadias


    Chapter 46: Etiology, Diagnosis, and Management of the Undescended Testis


    Chapter 47: Management of Abnormalities of the Genitalia in Girls


    Chapter 48: Disorders of Sexual Development: Etiology, Evaluation, and Medical Management


    Chapter 49: Surgical Management of Differences of Sexual Differentiation and Cloacal and Anorectal Malformations


    Chapter 50: Adolescent and Transitional Urology


    Chapter 51: Urologic Considerations in Pediatric Renal Transplantation


    Chapter 52: Pediatric Genitourinary Trauma


    Chapter 53: Pediatric Urologic Oncology: Renal and Adrenal


    Chapter 54: Pediatric Urologic Oncology: Bladder and Testis


    Chapter 55: Infections of the Urinary Tract


    Chapter 56: Inflammatory and Pain Conditions of the Male Genitourinary Tract: Prostatitis and Related Pain Conditions, Orchitis, and Epididymitis


    Chapter 57: Interstitial Cystitis/Bladder Pain Syndrome and Related Disorders


    Chapter 58: Sexually Transmitted Diseases


    Chapter 59: Cutaneous Diseases of the External Genitalia


    Chapter 60: Tuberculosis and Parasitic Infections of the Genitourinary Tract


    Chapter 61: Basic Principles of Immunology and Immunotherapy in Urologic Oncology


    Chapter 62: Molecular Genetics and Cancer Biology


    Chapter 63: Surgical, Radiographic, and Endoscopic Anatomy of the Male Reproductive System


    Chapter 64: Male Reproductive Physiology


    Chapter 65: Integrated Men’s Health: Androgen Deficiency, Cardiovascular Risk, and Metabolic Syndrome


    Chapter 66: Male Infertility


    Chapter 67: Surgical Management of Male Infertility


    Chapter 68: Physiology of Penile Erection and Pathophysiology of Erectile Dysfunction


    Chapter 69: Evaluation and Management of Erectile Dysfunction


    Chapter 70: Priapism


    Chapter 71: Disorders of Male Orgasm and Ejaculation


    Chapter 72: Surgery for Erectile Dysfunction


    Chapter 73: Diagnosis and Management of Peyronie’s Disease


    Chapter 74: Sexual Function and Dysfunction in the Female


    Chapter 75: Surgical, Radiographic, and Endoscopic Anatomy of the Retroperitoneum


    Chapter 76: Neoplasms of the Testis


    Chapter 77: Surgery of Testicular Tumors


    Chapter 78: Laparoscopic and Robotic-Assisted Retroperitoneal Lymphadenectomy for Testicular Tumors


    Chapter 79: Tumors of the Penis


    Chapter 80: Tumors of the Urethra


    Chapter 81: Inguinal Node Dissection


    Chapter 82: Surgery for Benign Disorders of the Penis and Urethra


    Chapter 83: Surgery of the Scrotum and Seminal Vesicles


    Chapter 84: Surgical, Radiologic, and Endoscopic Anatomy of the Kidney and Ureter


    Chapter 85: Physiology and Pharmacology of the Renal Pelvis and Ureter


    Chapter 86: Renal Physiology and Pathophysiology Including Renovascular Hypertension


    Chapter 87: Renal Insufficiency and Ischemic Nephropathy


    Chapter 88: Urologic Complications of Renal Transplantation


    Chapter 89: Management of Upper Urinary Tract Obstruction


    Chapter 90: Upper Urinary Tract Trauma


    Chapter 91: Urinary Lithiasis: Etiology, Epidemiology, and Pathogenesis


    Chapter 92: Evaluation and Medical Management of Urinary Lithiasis


    Chapter 93: Strategies for Nonmedical Management of Upper Urinary Tract Calculi


    Chapter 94: Surgical Management for Upper Urinary Tract Calculi


    Chapter 95: Lower Urinary Tract Calculi


    Chapter 96: Benign Renal Tumors


    Chapter 97: Malignant Renal Tumors


    Chapter 98: Urothelial Tumors of the Upper Urinary Tract and Ureter


    Chapter 99: Surgical Management of Upper Urinary Tract Urothelial Tumors


    Chapter 100: Retroperitoneal Tumors


    Chapter 101: Open Surgery of the Kidney


    Chapter 102: Laparoscopic and Robotic Surgery of the Kidney


    Chapter 103: Nonsurgical Focal Therapy for Renal Tumors


    Chapter 104: Treatment of Advanced Renal Cell Carcinoma


    Chapter 105: Surgical and Radiographic Anatomy of the Adrenals


    Chapter 106: Pathophysiology, Evaluation, and Medical Management of Adrenal Disorders


    Chapter 107: Surgery of the Adrenal Glands


    Chapter 108: Surgical, Radiographic, and Endoscopic Anatomy of the Female Pelvis


    Chapter 109: Surgical, Radiographic, and Endoscopic Anatomy of the Male Pelvis


    Chapter 110: Physiology and Pharmacology of the Bladder and Urethra


    Chapter 111: Pathophysiology and Classification of Lower Urinary Tract Dysfunction: Overview


    Chapter 112: Evaluation and Management of Women with Urinary Incontinence and Pelvic Prolapse


    Chapter 113: Evaluation and Management of Men with Urinary Incontinence


    Chapter 114: Urodynamic and Video-Urodynamic Evaluation of the Lower Urinary Tract


    Chapter 115: Urinary Incontinence and Pelvic Prolapse: Epidemiology and Pathophysiology


    Chapter 116: Neuromuscular Dysfunction of the Lower Urinary Tract


    Chapter 117: Overactive Bladder


    Chapter 118: The Underactive Detrusor


    Chapter 119: Nocturia


    Chapter 120: Pharmacologic Management of Lower Urinary Tract Storage and Emptying Failure


    Chapter 121: Conservative Management of Urinary Incontinence: Behavioral and Pelvic Floor Therapy, Urethral and Pelvic Devices


    Chapter 122: Electrical Stimulation and Neuromodulation in Storage and Emptying Failure


    Chapter 123: Retropubic Suspension Surgery for Incontinence in Women


    Chapter 124: Vaginal and Abdominal Reconstructive Surgery for Pelvic Organ Prolapse


    Chapter 125: Slings: Autologous, Biologic, Synthetic, and Mid-Urethral


    Chapter 126: Complications Related to the Use of Mesh and Their Repair


    Chapter 127: Additional Therapies for Storage and Emptying Failure


    Chapter 128: Aging and Geriatric Urology


    Chapter 129: Urinary Tract Fistulae


    Chapter 130: Bladder and Female Urethral Diverticula


    Chapter 131: Surgical Procedures for Sphincteric Incontinence in the Male


    Chapter 132: Bladder Surgery for Benign Disease


    Chapter 133: Genital and Lower Urinary Tract Trauma


    Chapter 134: Special Urologic Considerations in Transgender Individuals


    Chapter 135: Tumors of the Bladder


    Chapter 136: Management Strategies for Non–Muscle-Invasive Bladder Cancer (Ta, T1, and CIS)


    Chapter 137: Management of Muscle-Invasive and Metastatic Bladder Cancer


    Chapter 138: Surgical Management of Bladder Cancer: Transurethral, Open, and Robotic


    Chapter 139: Use of Intestinal Segments in Urinary Diversion


    Chapter 140: Cutaneous Continent Urinary Diversion


    Chapter 141: Orthotopic Urinary Diversion


    Chapter 142: Minimally Invasive Urinary Diversion


    Chapter 143: Development, Molecular Biology, and Physiology of the Prostate


    Chapter 144: Benign Prostatic Hyperplasia: Etiology, Pathophysiology, Epidemiology, and Natural History


    Chapter 145: Evaluation and Nonsurgical Management of Benign Prostatic Hyperplasia


    Chapter 146: Minimally Invasive and Endoscopic Management of Benign Prostatic Hyperplasia


    Chapter 147: Simple Prostatectomy: Open and Robotic-Assisted Laparoscopic Approaches


    Chapter 148: Epidemiology, Etiology, and Prevention of Prostate Cancer


    Chapter 149: Prostate Cancer Biomarkers


    Chapter 150: Prostate Biopsy: Techniques and Imaging


    Chapter 151: Pathology of Prostatic Neoplasia


    Chapter 152: Diagnosis and Staging of Prostate Cancer


    Chapter 153: Active Management Strategies for Localized Prostate Cancer


    Chapter 154: Active Surveillance of Prostate Cancer


    Chapter 155: Open Radical Prostatectomy


    Chapter 156: Laparoscopic and Robotic-Assisted Laparoscopic Radical Prostatectomy and Pelvic Lymphadenectomy


    Chapter 157: Radiation Therapy for Prostate Cancer


    Chapter 158: Focal Therapy for Prostate Cancer


    Chapter 159: Treatment of Locally Advanced Prostate Cancer


    Chapter 160: Management Strategies for Biochemical Recurrence of Prostate Cancer


    Chapter 161: Hormonal Therapy for Prostate Cancer


    Chapter 162: Treatment of Castration-Resistant Prostate Cancer

  • 2,40000lei 2100.00 lei

    The Handbook of Pharmaceutical Excipients collects together essential data on the physical properties of excipients as well as providing information on their safe use and applications. All of the 400+ monographs are also thoroughly cross-referenced and indexed to allow their identification by chemical, non-proprietary or trade names. It is internationally recognised as the authoritative source of information on pharmaceutical excipients and a comprehensive guide to uses, properties and safety.

    Changes to this new edition:

    • Contains revised and updated monographs
    • 20 + new monographs including amino acids Arginine, Proline and Asparagine
    • Includes newly added Raman spectra for many excipients
    • New chapter content including information on excipients in oral solid dose formulations, and pediatric formulations

  • 2,57000lei 2056.00 lei

    This fourth edition of Surgery of the Anus, Rectum and Colon continues to redefine the field, with its comprehensive coverage of common and rare colorectal conditions, advances in the molecular biology and genetics of colorectal diseases, and new laparoscopic techniques. Contributions from international experts on specialized topics and various new illustrations ensure that the extensive text is not only current and authoritative, but easy to understand. No other book provides the expertise of a world-class editorial team with the cutting-edge knowledge you need to master colorectal surgery

  • 2,57200lei 2050.00 lei




    The most comprehensive, multi-disciplinary text in the field, Cummings Otolaryngology: Head and Neck Surgery, 7th Edition, provides detailed, practical answers and easily accessible clinical content on the complex issues that arise for otolaryngologists at all levels, across all subspecialties. This award-winning text is a one-stop reference for all stages of your career-from residency and board certification through the challenges faced in daily clinical practice. Updated content, new otology editor Dr. Howard W. Francis, and new chapters and videos ensure that this 7th Edition remains the definitive reference in today’s otolaryngology.

    Table Of Contents:



    Part I: Measuring Outcomes and Performance

    1. Outcomes Research

    2. Interpreting Medical Data

    3. Evidence-Based Performance Measurement

    Part II: General Otolaryngology

    4. History, Physical Examination, and the Preoperative Evaluation

    5. General Considerations of Anesthesia and Management of the Difficult Airway

    6. Surgical Management of the Difficult Adult Airway

    7. Tracheotomy

    8. Overview of Diagnostic Imaging of the Head and Neck

    9. Deep Neck and Odontogenic Infections

    10. Head and Neck Manifestations in the Immunocompromised Host

    11. Laryngeal and Tracheal Manifestations of Systemic Disease

    12. Oral Manifestations of Systemic Diseases

    13. Otolaryngology in the Elderly

    14. Pain Management in the Head and Neck Patient

    15. Sleep Apnea and Sleep Disorders

    Part III: Facial Plastic and Reconstructive Surgery

    Section 1: Facial Surgery

    16. Aesthetic Facial Analysis

    17. Recognition and Treatment of Skin Lesions

    18. Scar Revision, Keloids, and Camouflage

    19. Facial Trauma: Soft Tissue Lacerations and Burns

    20. Maxillofacial Trauma

    21. Reconstruction of Facial Defects

    22. Hair Restoration: Medical and Surgical Techniques

    23. Management of Aging Skin

    24. Rhytidectomy and Facial Liposuction

    25. The Aesthetic Brow and Forehead

    26. Blepharoplasty

    27. Mentoplasty

    28. Otoplasty

    Section 2: Rhinoplasty

    29. The Nasal Septum

    30. Nasal Fractures

    31. Rhinoplasty

    32. Special Rhinoplasty Techniques

    33. Non-Caucasian Rhinoplasty

    34. Revision Rhinoplasty

    Part IV: Sinus, Rhinology and Allergy/Immunology

    35. Allergy and Immunology of the Upper Airway

    36. Olfactory function and dysfunction

    37. Objective Assessment of Nasal Function

    38. Imaging of Nose and Sinuses

    39. Non-allergic Rhinitis

    40. Acute Rhinosinusitis: Pathogenesis, Treatment and Complications

    41. Pathogenesis of Chronic Rhinosinusitis

    42. Chronic Rhinosinusitis: Evidence based Medical Treatment

    43. Chronic Rhinosinusitis: Outcomes of Medical and Surgical Treatment

    44. Primary Sinus Surgery

    45. Causes of Failure, Revision Surgery for Rhinosinusitis, and Management of Complications in Endoscopic Sinus Surgery

    46. Management of the Frontal Sinuses

    47. Epistaxis

    48. Cerebrospinal Fluid Rhinorrhea

    49. Sino-orbital Interface

    50. Benign Tumors of the Sinonasal Tract

    51. Systemic Disease of the Nose and Sinuses

    52. Facial Pain

    Part V: Laryngology and Bronchoesophagology

    53. Laryngeal and Pharyngeal Function

    54. Visual Documentation of the Larynx

    55. Voice Evaluation and Therapy

    56. Neurologic Evaluation of the Larynx and Pharynx

    57. Neurologic Disorders of the Larynx

    58. The Professional Voice

    59. Laser Surgery: Basic Principles and Safety Considerations

    60. Benign Vocal Fold Mucosal Disorders

    61. Acute and Chronic Laryngopharyngitis

    62. Medialization Thyroplasty

    63. Arytenoid Adduction and Abduction

    64. Laryngeal Reinnervation

    65. Chronic Aspiration

    66. Laryngeal and Esophageal Trauma

    67. Surgical Management of Upper Airway Stenosis

    68. Diseases of the Esophagus

    69. Transnasal Esophagoscopy

    70. Zenker Diverticulum

    71. Tracheobronchial Endoscopy

    Part VI: Head and Neck Surgery and Oncology

    Section 1: General Considerations

    72. Fundamentals of Molecular Biology and Gene Therapy

    73. Biology of Head and Neck Cancers

    74. Human Papillomavirus (HPV) and the Epidemiology of Head and Neck Cancer

    75. Radiotherapy for Head and Neck Cancer: Radiation Physics, Radiobiology, and Clinical Principles

    76. Chemotherapy and Targeted Biologic Agents for Head and Neck Cancer

    77. Skin Flap Physiology and Wound Healing

    78. Free Tissue Transfer

    79. Integrating Palliative and Curative Care Strategies in the Practice of Otolaryngology

    80. The Management of Cutaneous Head and Neck Melanoma

    Section 2: Salivary Glands

    81. Physiology of the Salivary Glands

    82. Diagnostic Imaging and Fine-needle Aspiration of the Salivary Glands

    83. Inflammatory Disorders of the Salivary Glands

    84. Benign Neoplasms of the Salivary Glands

    85. Malignant Neoplasms of the Salivary Glands

    Section 3: Oral Cavity

    86. Physiology of the Oral Cavity

    87. Oral Mucosal Lesions

    88. Odontogenesis, Odontogenic Cysts, and Odontogenic Tumors

    89. Temporomandibular Joint Disorders

    90. Benign Tumors and Tumor-like Lesions of the Oral Cavity

    91. Malignant Neoplasms of the Oral Cavity

    92. Reconstruction of the Mandible and Maxilla

    93. Prosthetic Management of Head and Neck Defects

    94. Malignancies of the Paranasal Sinus

    Section 4: Pharynx and Esophagus

    95. Benign and Malignant Tumors of the Nasopharynx

    96. Malignant Neoplasms of the Oropharynx

    97. Transoral Approaches to Malignant Neoplasms of the Oropharynx

    98. Reconstruction of the Oropharynx

    99. Swallowing Function and Implications in Head and Neck Cancer

    100. Diagnostic Imaging of the Pharynx and Esophagus

    101. Neoplasms of the Hypopharynx and Cervical Esophagus

    102. Radiotherapy and Chemotherapy of Squamous Cell Carcinomas of the Hypopharynx and Esophagus

    103. Reconstruction of the Hypopharynx and Esophagus

    Section 5: Larynx

    104. Diagnostic Imaging of the Larynx

    105. Malignant Tumors of the Larynx

    106. Management of Early Glottic Cancer

    107. Transoral Laser Microresection of Advanced Laryngeal Tumors

    108. Conservation Laryngeal Surgery

    109. Total Laryngectomy and Laryngopharyngectomy

    110. Radiation Therapy for Cancer of the Larynx and Hypopharynx

    111. Vocal and Speech Rehabilitation After Laryngectomy

    112. Diagnosis and Management of Tracheal Neoplasms

    Section 6: Neck

    113. Differential Diagnosis of Neck Masses

    114. Ultrasound Imaging of the Neck

    115. Neoplasms of the Neck

    116. Lymphomas Presenting in the Head and Neck

    117. Radiation Therapy and Management of the Cervical Lymph Nodes and Malignant Skull Base Tumors

    118. Neck Dissection

    119. Complications of Neck Surgery

    120. Penetrating and Blunt Trauma to the Neck

    Section 7: Thyroid/Parathyroid

    121. Disorders of the Thyroid Gland

    122. Management of Thyroid Neoplasms

    123. Management of Parathyroid Disorders

    124. Surgical Robotics in Otolaryngology

    125. Management of Thyroid Eye Disease (Graves' Ophthalmopathy)

    Part VII: Otology, Neurotology, and Skull Base Surgery

    Section 1: Basic Science

    126. Anatomy of the Temporal Bone, External Ear, and Middle Ear


    128. Physiology of the Auditory System

    129. Anatomy of the Vestibular System

    130. Anatomy and Physiology of the Eustachian Tube

    131. Clinical Evaluation and Management of the Eustachian Tube


    133. Geriatric Otology: Population Health and Clinical Implications

    Section 2: Diagnostic Assessment

    134. Diagnostic Audiology and Electrophysiologic Assessment of Hearing

    135. Neuroradiology of the Temporal Bone and Skull Base

    136. Interventional Neuroradiology of the Skull Base, Head and Neck

    137. Otologic Symptoms and Syndromes

    Section 3: External Ear

    138. Infections of the External Ear

    139. Topical Therapies of External Ear Disorders

    Section 4: Middle Ear, Mastoid and Temporal Bone

    140. Chronic Otitis Media, Mastoiditis, and Petrositis

    141. Complications of Temporal Bone Infections

    142. Tympanoplasty and Ossiculoplasty

    143. Mastoidectomy: Surgical Techniques

    144. Middle Ear Endoscopic Surgery

    145. Clinical Assessment and Surgical Treatment of Conductive Hearing Loss

    146. Otosclerosis

    147. Management of Temporal Bone Trauma

    Section 5: Inner Ear

    148. Cochlear Transduction and the Molecular Basis of Auditory Pathology

    149. Genetics of Ear Disorders

    150. Genetic Sensorineural Hearing Loss

    151. Otologic Manifestations of Systemic Disease

    152. Sensorineural Hearing Loss in Adults

    153. Tinnitus and Hyperacusis

    154. Noise-Induced Hearing Loss

    155. Infections of the Labyrinth

    156. Autoimmune Inner-Ear Disease

    157. Vestibular and Auditory Ototoxicity

    158. Pharmacologic and Molecular Therapies of the Cochlear and Vestibular Labyrinth

    Section 6: Auditory Prosthetic Stimulation, Devices, and Rehabilitative Audiology

    159. Implantable Hearing Devices

    160. Cochlear Implantation: Patient Evaluation and Device Selection

    161. Medical and Surgical Considerations in Cochlear Implantation

    162. Cochlear Implantation in Adults: Results, Outcomes and Rehabilitation

    163. Auditory Brainstem Implantation

    164. Hearing Aid Amplification

    Section 7: Vestibular Disorders

    165. Principles of Applied Vestibular Physiology

    166. Evaluation of the Patient with Dizziness

    167. Peripheral Vestibular Disorders

    168. Central Vestibular Disorders

    169. Surgery for Vestibular Disorders

    170. Vestibular and Balance Rehabilitation Therapy: Program Essentials

    Section 8: Facial Nerve Disorders

    171. Tests of Facial Nerve Function

    172. Clinical Disorders of the Facial Nerve

    173. Intratermporal Facial Nerve Surgery

    174. Rehabilitation of Facial Paralysis

    Section 9: Cranial Base

    175. Surgical Anatomy of the Lateral Skull Base

    176. Surgery of the Anterior and Middle Cranial Base

    177. Transnasal Endoscopic-Assisted Surgery of the Anterior Skull Base

    178. Temporal Bone Neoplasms and Lateral Cranial Base Surgery

    179. Neoplasms of the Posterior Fossa

    180. Intraoperative Monitoring of Cranial Nerves in Neurotologic Surgery

    181. Radiation Therapy of Benign Tumors of the Cranial Base

    Part VIII: Pediatric Otolaryngology

    Section 1: General

    182. General Considerations in Pediatric Otolaryngology

    183. Pediatric Speech Disorders

    184. Anesthesia in Pediatric Otolaryngology

    185. Nonobstructive Pediatric Sleep Disorders

    186. Evaluation and Management of Pediatric Obstructive Sleep Apnea

    Section 2: Craniofacial

    187. Craniofacial Surgery for Congenital and Acquired Deformities

    188. Cleft Lip and Palate

    189. Velopharyngeal Dysfunction

    190. Congenital and Acquired Malformations of the Nose and Nasopharynx

    191. Pediatric Facial Fractures

    Section 3: Hearing Loss and Pediatric Otology

    192. Pediatric Otologic Surgery

    193. Early Detection and Diagnosis of Infant Hearing Impairment

    194. Congenital Malformations of the Inner Ear

    195. Microtia Reconstruction

    196. Pediatric Cochlear Implantation

    197. Evaluation and Management of Congenital Aural Atresia

    198. Evaluation and Management of Pediatric Vestibular Disorders