Description: Through six outstanding and award-winning editions, Ryan’s Retina has offered unsurpassed coverage of this complex subspecialty-everything from basic science through the latest research, therapeutics, technology, and surgical techniques. The fully revised 7th Edition, edited by Drs. SriniVas R. Sadda, Andrew P. Schachat, Charles P. Wilkinson, David R. Hinton, Peter Wiedemann, K. Bailey Freund, and David Sarraf, continues the tradition of excellence, balancing the latest scientific research and clinical correlations and covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology. More than 300 global contributors share their knowledge and expertise to create the most comprehensive reference available on retina today.
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Prelims 1 Fluorescein Angiography: Basic Principles and Interpretation 1 Fluorescein Angiography: Basic Principles and Interpretation 2 Clinical Applications of Diagnostic Indocyanine Green Angiography 2 Clinical Applications of Diagnostic Indocyanine Green Angiography 3 Optical Coherence Tomography 3 Optical Coherence Tomography 4 Optical Coherence Tomography Angiography (OCTA) 4 Autofluorescence Imaging 5 Autofluorescence Imaging 5 Widefield Imaging 6 Widefield Imaging 6 Intraoperative OCT Imaging 7 Advanced Imaging Technologies 7 Advanced Imaging Technologies 8 Artificial Intelligence and Advanced Imaging Analysis 8 Advanced Image Analysis 9 Clinical Electrophysiology 9 Electrogenesis of the Electroretinogram 10 Diagnostic Ophthalmic Ultrasound 10 Clinical Electrophysiology 11 Color Vision and Night Vision 11 Diagnostic Ophthalmic Ultrasound 12 Visual Acuity and Contrast Sensitivity 12 Color Vision and Night Vision 13 Visual Fields in Retinal Disease 13 Visual Acuity and Contrast Sensitivity 14 The Development of the Retina 14 Visual Fields in Retinal Disease 15 Function and Anatomy of the Mammalian Retina 15 The Development of the Retina 16 Structure and Function of Rod and Cone Photoreceptors 16 Structure and Function of Rod and Cone Photoreceptors 17 Cell Biology of the Retinal Pigment Epithelium 17 Function and Anatomy of the Mammalian Retina 18 Glial Cells of the Fovea 18 Cell Biology of the Retinal Pigment Epithelium 19 Retinal and Choroidal Vasculature: Retinal Oxygenation 19 Cell Biology of Retinal Glia 20 Mechanisms of Normal Retinal Adhesion 20 Retinal and Choroidal Vasculature: Retinal Oxygenation 21 Structure, Function, and Pathology of Bruch’s Membrane 21 Mechanisms of Normal Retinal Adhesion 22 Vitreous and Vitreoretinal Interface 22 Structure, Function, and Pathology of Bruch’s Membrane 23 Mechanisms of Oxidative Stress in Retinal Injury 23 Vitreous and Vitreoretinal Interface 24 Mechanisms of Endoplasmic Reticulum Stress in Retinal Disease 24 Mechanisms of Oxidative Stress in Retinal Injury 25 Cell Death, Apoptosis, and Autophagy in Retinal Injury 25 Mechanisms of Endoplasmic Reticulum Stress in Retinal Disease 26 Inflammation and Immune Responses In Retinal Health and Disease 26 Cell Death, Apoptosis, and Autophagy in Retinal Injury 27 Basic Mechanisms of Pathological Retinal and Choroidal Angiogenesis 27 Blood-Retinal Barrier, Immune Privilege, and Autoimmunity 27 "Basic Mechanisms of Pathological Retinal and Choroidal Angiogenesis " 27 Inflammation and Immune Responses In Retinal Health and Disease 28 Blood-Retinal Barrier, Immune Privilege, and Autoimmunity 28 Cellular Effects of Detachment and Reattachment on the Neural Retina and the Retinal Pigment Epithelium 28 "Basic Mechanisms of Pathological Retinal and Choroidal Angiogenesis " 29 Cell Biology of Retinal Glia 29 Structure, Function, and Pathology of Bruch’s Membrane 29 Retinal and Choroidal Vasculature: Retinal Oxygenation 29 Pathogenesis of Serous Detachment of the Retina and Pigment Epithelium 29 Mechanisms of Macular Edema and Therapeutic Approaches 29 Genetic Mechanisms of Retinal Disease 29 Blood-Retinal Barrier, Immune Privilege, and Autoimmunity 30 Cellular Effects of Detachment and Reattachment on the Neural Retina and the Retinal Pigment Epithelium 30 Mechanisms of Macular Edema and Therapeutic Approaches 31 Retinal Manifestation of Neurodegeneration: A Focus on Alzheimer's Disease 31 Cellular Effects of Detachment and Reattachment on the Neural Retina and the Retinal Pigment Epithelium 32 Genetic Mechanisms of Retinal Disease 32 Pathogenesis of Serous Detachment of the Retina and Pigment Epithelium 33 Mitochondrial Genetics of Retinal Disease 33 Genetic Mechanisms of Retinal Disease 34 Epigenetic Mechanisms of Retinal Disease 34 Neuroprotection 34 Mitochondrial Genetics of Retinal Disease 35 Microbiome and Retinal Disease 35 Epigenetic Mechanisms of Retinal Disease 36 Electrogenesis of the Electroretinogram 36 Advanced Image Analysis 36 Intraoperative OCT Imaging 36 Gene Therapy for Retinal Disease 36 Macular Dystrophies 36 Gene Therapy for Retinal Disease 37 Stem Cells and Cellular Therapy 37 Stem Cells and Cellular Therapy 38 Nanomedicine in Ophthalmology 38 Nanomedicine in Ophthalmology 39 Neuroprotection 39 Neuroprotection 40 Drug Delivery 40 Drug Delivery 41 Retinal Laser Therapy: Biophysical Basis and Applications 41 Diabetic Retinopathy: Genetics and Etiologic Mechanisms 41 Retinal Laser Therapy: Biophysical Basis and Applications 42 Macular Dystrophies 42 Retinitis Pigmentosa and Allied Disorders 43 Retinitis Pigmentosa and Allied Disorders 43 Hereditary Vitreoretinal Degenerations 44 The Epidemiology of Diabetic Retinopathy 44 Proliferative Diabetic Retinopathy 44 Abnormalities of Rod and Cone Function 44 Macular Dystrophies 45 Hereditary Vitreoretinal Degenerations 45 Hereditary Choroidal Diseases 46 Hereditary Choroidal Diseases 46 Abnormalities of Cone and Rod Function 47 Diabetic Retinopathy: Genetics and Etiologic Mechanisms 47 The Epidemiology of Diabetic Retinopathy 48 Diabetes Mellitus 48 Diabetic Retinopathy: Genetics and Etiologic Mechanisms 49 Nonproliferative Diabetic Retinopathy and Diabetic Macular Edema 49 Medical Management of Diabetes Mellitus 49 Medical Management of Diabetes Mellitus 50 Proliferative Diabetic Retinopathy 50 Nonproliferative Diabetic Retinopathy and Diabetic Macular Edema 51 Telescreening for Diabetic Retinopathy 51 Proliferative Diabetic Retinopathy 52 Hypertension 52 Hypertension 53 Retinal Artery and Capillary Occlusions 53 Telescreening for Diabetic Retinopathy 54 Acquired Retinal Macroaneurysms 54 Retinal Artery Obstructions 55 Telescreening for Retinopathy of Prematurity 55 Branch Retinal Vein Occlusion 55 Acquired Retinal Macroaneurysms 56 Central Retinal Vein Occlusion 56 Branch Vein Occlusion 57 Macular Telangiectasia Type 2 57 Central Retinal Vein Occlusion 58 Coats Disease 58 Macular Telangiectasia 59 Hemoglobinopathies 59 Coats Disease 60 Radiation Retinopathy 60 Hemoglobinopathies 61 Ocular Ischemic Syndrome 61 Radiation Retinopathy 62 Systemic Coagulopathy Syndromes 62 Ocular Ischemic Syndrome 63 Pediatric Retinal Vascular Diseases Retinopathy of Prematurity 63 Coagulopathies 64 Epidemiology and Risk Factors for Age-Related Macular Degeneration 64 Pediatric Retinal Vascular Diseases 65 Pathogenetic Mechanisms in Age-Related Macular Degeneration 65 Telescreening for Retinopathy of Prematurity 66 Age-Related Macular Degeneration: Non-Neovascular AMD: Early, Intermediate, and Geographic Atrophic Stages 66 Epidemiology and Risk Factors for Age-Related Macular Degeneration 67 Neovascular Age-Related Macular Degeneration 67 Pathogenetic Mechanisms in Age-Related Macular Degeneration 68 Pharmacotherapy of Age-Related Macular Degeneration 68 Age-Related Macular Degeneration: Non-neovascular Early AMD, Intermediate AMD, and Geographic Atrophy 69 Pathologic Myopia 69 Neovascular (Exudative or “Wet”) Age-Related Macular Degeneration 70 Angioid Streaks 70 Pharmacotherapy of Age-Related Macular Degeneration 71 Ocular Histoplasmosis 71 Myopic Macular Degeneration 72 Pachychoroid Disease and Its Association with Polypoidal Choroidal Vasculopathy 72 Angioid Streaks 73 Central Serous Chorioretinopathy 73 Ocular Histoplasmosis 74 Uveal Effusion Syndrome and Hypotony Maculopathy 74 Polypoidal Choroidal Vasculopathy 75 Sympathetic Ophthalmia 75 Central Serous Chorioretinopathy 76 Vogt-Koyanagi-Harada Disease 76 Uveal Effusion Syndrome and Hypotony Maculopathy 77 White Spot Syndromes and Related Diseases 77 Sympathetic Ophthalmia 78 Autoimmune Retinopathies 78 Vogt-Koyanagi-Harada Disease 79 Sarcoidosis 79 White Spot Syndromes and Related Diseases 80 Intermediate Uveitis 80 Autoimmune Retinopathies 81 Rheumatic Diseases 81 Sarcoidosis 82 HIV-Associated Infections 82 Intermediate Uveitis 83 Mycobacterial Infections 83 Rheumatic Diseases 84 Eales Disease 84 HIV-Associated Infections 85 Spirochetal Infections 85 Mycobacterial Infections 86 Ocular Toxoplasmosis 86 Eales Disease 87 Helminthic Disease 87 Spirochetal Infections 88 Endogenous Endophthalmitis: Bacterial and Fungal 88 Ocular Toxoplasmosis 89 Acute Retinal Necrosis Syndrome 89 Helminthic Disease 90 Drug Toxicity of the Posterior Segment 90 Endogenous Endophthalmitis: Bacterial and Fungal 91 Photic Retinal Injuries: Mechanisms, Hazards, and Prevention 91 Acute Retinal Necrosis Syndrome 92 Traumatic Chorioretinopathies 92 Drug Toxicity of the Posterior Segment 93 Retinal and Choroidal Disorders in Pregnancy (Pregnancy-Related Diseases) 93 Photic Retinal Injuries: Mechanisms, Hazards, and Prevention 94 Optic Disc Anomalies, Drusen, Pits, Hypoplasia and Associated Retinal Pathology 94 Traumatic Chorioretinopathies 95 Retina-Related Clinical Trials: A Resource Bibliography 95 Pregnancy-Related Diseases 96 Pathogenetic Mechanisms of Retinal Detachment 96 Optic Disc Anomalies, Pits, and Associated Serous Macular Detachment 97 Nonrhegmatogenous Retinal Detachment 97 Retina-Related Clinical Trials: A Resource Bibliography 98 Degenerative Retinoschisis 98 Pathogenetic Mechanisms of Retinal Detachment 99 Pathogenesis of Proliferative Vitreoretinopathy 99 Nonrhegmatogenous Retinal Detachment 100 Pathophysiology of Ocular Trauma 100 Senile Retinoschisis 101 The Biomechanics of Scleral Buckles in the Treatment of Retinal Detachment 101 Pathogenesis of Proliferative Vitreoretinopathy 102 Techniques of Scleral Buckling 102 Pathophysiology of Ocular Trauma 103 Principles and Techniques of Vitreoretinal Surgery 103 The Effects and Action of Scleral Buckles in the Treatment of Retinal Detachment 104 Intraoperative OCT Imaging 104 Techniques of Scleral Buckling 105 Primary Vitrectomy in Rhegmatogenous Retinal Detachment 105 Principles and Techniques of Vitreoretinal Surgery 106 Pneumatic Retinopexy 106 Primary Vitrectomy in Rhegmatogenous Retinal Detachment 107 Special Adjuncts to Treatment 107 Pneumatic Retinopexy 108 Optimal Procedures for Retinal Detachment Repair 108 Special Adjuncts to Treatment 109 Prevention of Retinal Detachment 109 Optimal Procedures for Retinal Detachment Repair 110 Proliferative Vitreoretinopathy 110 Prevention of Retinal Detachment 111 Retinotomies and Retinectomies 111 Proliferative Vitreoretinopathy 112 Giant Retinal Tear 112 Retinotomies and Retinectomies 113 Surgery for Ocular Trauma: Principles and Techniques of Treatment 113 360 Degree Macular Translocation 113 Surgical Management of Choroidal Neovascularization and Subretinal Hemorrhage 113 Giant Retinal Tear 114 Surgery for Proliferative Diabetic Retinopathy 114 Surgery for Ocular Trauma: Principles and Techniques of Treatment 115 Management of Combined Inflammatory and Rhegmatogenous Retinal Detachment 115 Surgery for Proliferative Diabetic Retinopathy 116 High Myopia and the Vitreoretinal Complications 116 Management of Combined Inflammatory and Rhegmatogenous Retinal Detachment 117 Surgical Management of Retinopathy of Prematurity 117 High Myopia and the Vitreoretinal Complications 118 Surgery for Pediatric Vitreoretinal Disorders 118 Surgical Management of Retinopathy of Prematurity 119 Epiretinal Membranes, Vitreoretinal Traction, Cystoid Macular Edema, and Submacular Hemorrhage 119 Surgery for Pediatric Vitreoretinal Disorders 120 Macular Hole 120 Epiretinal Membranes, Vitreoretinal Traction and Cystoid Macular Edema 121 Retinal Pigment Epithelium and Choroid Translocation in Patients with Age-Related Macular Degeneration 121 Macular Hole 122 Infectious Endophthalmitis 122 Surgical Management of Choroidal Neovascularization and Subretinal Hemorrhage 123 Diagnostic and Therapeutic Vitrectomy for Uveitis 123 360 Degree Macular Translocation 124 Vitreous, Retinal, and Choroidal Biopsy 124 Retinal Pigment Epithelium and Choroid Translocation in Patients with Age-Related Macular Degeneration 125 Transplantation Frontiers 125 Infectious Endophthalmitis 126 Artificial Vision 126 Remote Effects of Cancer on the Retina 126 Diagnostic and Therapeutic Vitrectomy for Uveitis 127 Pharmacology During Surgery 127 Vitreous, Retinal, and Choroidal Biopsy 128 Complications in Vitreoretinal Surgery 128 Transplantation Frontiers 129 Retinoblastoma 129 Artificial Vision 130 Cavernous Hemangioma 130 Epidemiology of Posterior Uveal Melanoma 130 Pharmacology During Surgery 131 Capillary Hemangioblastoma of the Retina and von Hippel-Lindau Disease 131 Complications in Vitreoretinal Surgery 132 Tuberous Sclerosis and the Eye 132 Retinoblastoma 133 Phakomatoses 133 Cavernous Hemangioma 134 Retinal Metastases 134 Capillary Hemangioblastoma of the Retina and von Hippel-Lindau Disease 135 Tuberous Sclerosis and the Eye 135 Remote Effects of Cancer: Paraneoplastic Autoimmune Retinopathies 136 Optic Disc Melanocytoma 136 Phakomatoses 137 Congenital Hypertrophy of the Retinal Pigment Epithelium 137 Retinal Metastases 138 Combined Hamartoma of the Retinal Pigment Epithelium and Retina 138 Remote Effects of Cancer on the Retina 139 Choroidal Nevi 139 Laser Treatment of Choroidal Melanoma 139 Melanocytoma of the Optic Disc 140 Epidemiology of Posterior Uveal Melanoma 140 Congenital Hypertrophy of the Retinal Pigment Epithelium 141 Prognosis of Posterior Uveal Melanoma 141 Combined Hamartoma of the Retinal Pigment Epithelium and Retina 142 Molecular Genetics of Choroidal Melanoma 142 Choroidal Nevi 143 Pathology of Choroidal Melanoma 143 Epidemiology of Posterior Uveal Melanoma 144 Overview of Management of Posterior Uveal Melanoma 144 Prognosis of Posterior Uveal Melanoma 145 Enucleation for Choroidal Melanomas 145 Molecular Genetics of Choroidal Melanoma 146 Brachytherapy for Choroidal Melanoma 146 Pathology of Choroidal Melanoma 147 Charged-Particle Irradiation of Uveal Melanoma 147 Overview of Management of Posterior Uveal Melanoma 148 Surgical Resection of Choroidal Melanoma 148 Enucleation for Choroidal Melanomas 149 Laser Treatment of Choroidal Melanoma 149 Brachytherapy for Choroidal Melanoma 150 Systemic Evaluation and Management of Patients with Metastatic Uveal Melanoma 150 Charged-Particle Irradiation of Uveal Melanoma 151 Collaborative Ocular Melanoma Study 151 Surgical Resection of Choroidal Melanoma 152 Choroidal Metastases 152 Laser Treatment of Choroidal Melanoma 153 Choroidal Osteoma 153 Systemic Evaluation and Management of Patients with Uveal Melanoma 154 Circumscribed Choroidal Hemangioma 154 Collaborative Ocular Melanoma Study 155 Miscellaneous Uveal Tumors 155 Choroidal Metastases 156 Leukemias and Lymphomas 156 Choroidal Osteoma 157 Primary Vitreoretinal Lymphoma 157 Circumscribed Choroidal Hemangioma Index 158 Miscellaneous Uveal Tumors 159 Leukemias and Lymphomas 160 Primary Vitreoretinal Lymphoma
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