Cutaneous Melanoma

Sixth edition includes three new chapters and remaining chapters extensively updated and revised to include the latest clinical, radiological, and pathological data and clinical trial advances

Written by leading melanoma experts from the United States, Australia, and Europe

Incorporates clinical outcomes of more than 70,000 patients treated at major melanoma centers throughout the world

The definitive and most authoritative textbook on melanoma used worldwide

Offers the reader a balanced perspective of the risks and benefits involved in each treatment modality

About this book

Written by the leading melanoma experts from the United States, Australia, and Europe, this new edition incorporates the clinical outcomes of more than 70,000 patients treated at major melanoma centers throughout the world and is the definitive and most authoritative textbook on melanoma used worldwide. Providing the most up-to-date and comprehensive information needed for the clinical management and scientific study of melanoma, Cutaneous Melanoma, 6th edition covers everything from precursors of melanoma to advanced stages of metastatic disease.

Table of Contents:

Front Matter

Pages i-xxix

Biology and Immunology of Melanoma

Front Matter

Pages 1-1

Biology of Melanocytes and Primary Melanoma

M. Raza Zaidi, David E. Fisher, Helen Rizos

Pages 3-40

Immunology of Melanoma

Paul F. Robbins, Yong-Chen Lu

Pages 41-72

Biomarkers for Melanoma

Dirk Schadendorf, Keith T. Flaherty, Lyn M. Duncan, Mohammed Kashani-Sabet, Selma Ugurel

Pages 73-104

Diagnosis and Staging

Front Matter

Pages 105-105

Clinical Presentations of Melanoma

Allan C. Halpern, Ashfaq A. Marghoob, Arthur J. Sober, Victoria Mar, Michael A. Marchetti

Pages 107-144

Dermoscopy/Confocal Microscopy for Melanoma Diagnosis

Katie J. Lee, Nicola di Meo, Oriol Yélamos, Josep Malvehy, Iris Zalaudek, H. Peter Soyer

Pages 145-194

Biopsy of Suspected Melanoma

Noah Smith, Timothy M. Johnson, John W. Kelly, Arthur J. Sober, Christopher Bichakjian

Pages 195-203

Lymphoscintigraphy in Patients with Melanoma

Roger F. Uren, Omgo E. Nieweg, John F. Thompson

Pages 205-237

Biopsy of the Sentinel Lymph Node

Mark B. Faries, Alistair J. Cochran, Michael McLemore, Vernon K. Sondak, Sandra L. Wong, John F. Thompson

Pages 239-270

Melanoma Prognosis and Staging

Emily Z. Keung, Charles M. Balch, John F. Thompson, John M. Kirkwood, Richard A. Scolyer, Vernon K. Sondak et al.

Pages 271-297

Models for Predicting Melanoma Outcome

Lauren E. Haydu, Phyllis A. Gimotty, Daniel G. Coit, John F. Thompson, Jeffrey E. Gershenwald

Pages 299-314

Pathology

Front Matter

Pages 315-315

Classification and Histopathology of Melanoma

Richard A. Scolyer, Victor G. Prieto, David E. Elder, Alistair J. Cochran, Martin C. Mihm

Pages 317-379

Molecular Pathology and Genomics of Melanoma

Klaus Georg Griewank, Rajmohan Murali, Thomas Wiesner

Pages 381-422

Epidemiology and Prevention of Melanoma

Front Matter

Pages 423-423

Clinical Epidemiology of Melanoma

Catherine M. Olsen, David C. Whiteman

Pages 425-449

Molecular Epidemiology of Melanoma

Anne E. Cust, Hensin Tsao, Marianne Berwick, Graham J. Mann, Mark M. Iles

Pages 451-469

Clinical Genetics and Risk Assessment of Melanoma

V. Bataille, Hensin Tsao, S. Raimondi, S. Gandini

Pages 471-499

Acquired Precursor Lesions and Phenotypic Markers of Increased Risk for Cutaneous Melanoma

Cristian Navarrete-Dechent, Alon Scope, Hensin Tsao, Nadeem G. Marghoob, Arthur J. Sober, Ashfaq A. Marghoob

Pages 501-524

Melanoma Prevention and Screening

Susan M. Swetter, Alan C. Geller, Sancy A. Leachman, John M. Kirkwood, Alexander Katalinic, Jeffrey E. Gershenwald

Pages 525-570

Management of Primary Melanoma and Locoregional Metastases

Front Matter

Pages 571-571

Treatment of Primary Melanomas

John F. Thompson, Michael A. Henderson, Gabrielle Williams, Merrick I. Ross

Pages 573-594

Reconstructive Options Following Surgery of Primary Melanoma

Marc Moncrieff, Brian Gastman, Rogerio Izar Neves, Howard Peach, Anthony P. Tufaro

Pages 595-656

Axillary and Epitrochlear Lymph Node Dissection for Melanoma

Sandra L. Wong, Douglas S. Tyler, Charles M. Balch, John F. Thompson, Kelly M. McMasters

Pages 657-667

Inguinofemoral, Iliac/Obturator, and Popliteal Lymphadenectomy for Melanoma

Keith A. Delman, Lesly A. Dossett, Clara R. Farley, Kelly M. McMasters, Omgo E. Nieweg

Pages 669-687

Neck Dissection and Parotidectomy for Melanoma

Brian Gastman, Rebecca Knackstedt, Ryan P. Goepfert, Baran Sumer, Ashok Shaha, Michael E. Kupferman

Pages 689-704

Local and Recurrent Regional Metastases of Melanoma

Matthew C. Perez, Kenneth K. Tanabe, Charlotte E. Ariyan, John T. Miura, Dorotea Mutabdzic, Jeffrey M. Farma et al.

Pages 705-737

Radiotherapy for Primary and Regional Melanoma

Angela M. Hong, Graham Stevens

Pages 739-745

Adjuvant Systemic Therapy for High-Risk Melanoma Patients

Yana G. Najjar, Ryan Massa, Vernon K. Sondak, Alexander M. M. Eggermont, Helen Gogas, John M. Kirkwood

Pages 747-766

Neoadjuvant Systemic Therapy for High-Risk Melanoma Patients

Emily Z. Keung, Rodabe N. Amaria, Vernon K. Sondak, Merrick I. Ross, John M. Kirkwood, Jennifer A. Wargo

Pages 767-793

Hyperthermic Regional Perfusion for Melanoma of the Limbs

Douglas S. Tyler, Douglas L. Fraker, Harald J. Hoekstra, H. Richard Alexander Jr.

Pages 795-825

Isolated Limb Infusion for Melanoma

Georgia Marie Beasley, John T. Miura, Jonathan S. Zager, Douglas S. Tyler, John F. Thompson, Hidde M. Kroon

Pages 827-850

Surveillance and Follow-Up of Melanoma Patients

Rachael L. Morton, Anne Brecht Francken, Mbathio Dieng

Pages 851-866

Local Melanoma Recurrence, Satellitosis, and In-transit Metastasis: Incidence, Outcomes, and Selection of Treatment Options

John F. Thompson, Nicola Mozzillo, Merrick I. Ross

Pages 867-894

Uncommon Presentations of Melanoma

Front Matter

Pages 895-895

Acral Lentiginous Melanoma

Yukiko Teramoto, Hector Martinez-Said, Jun Guo, Claus Garbe

Pages 897-924

Lentigo Maligna Melanoma

Cristian Navarrete-Dechent, Kelly C. Nelson, Anthony M. Rossi, Erica H. Lee, Christopher A. Barker, Kishwer S. Nehal et al.

Pages 925-951

Mucosal Melanoma

Michael A. Henderson, Charles M. Balch, Claus Garbe, Alexander N. Shoushtari, Bin Lian, Chuanliang Cui et al.

Pages 953-968

Melanoma in Children and Teenagers

Ines B. Brecht, Ira J. Dunkel, Claus Garbe

Pages 969-982

Pregnancy and the Use of Hormones in Melanoma Patients

Alexandra Gangi, Robyn Saw, Vernon K. Sondak

Pages 983-996

Diagnosis of Stage IV Melanoma

Ahmad A. Tarhini, Sanjiv S. Agarwala, Arjun Khunger, Richard L. Wahl, Charles M. Balch

Pages 997-1043

Management of Distant Metastases

Front Matter

Pages 1045-1045

Evolving Role of Chemotherapy-Based Treatment of Metastatic Melanoma

Sanjiv S. Agarwala, Mark R. Middleton, Michael B. Atkins

Pages 1047-1066

Targeted Therapies for BRAF-Mutant Metastatic Melanoma

Douglas B. Johnson, Reinhard Dummer, Keith T. Flaherty, Keiran S. Smalley

Pages 1067-1085

Molecularly Targeted Therapy for Patients with BRAF Wild-Type Melanoma

Sunandana Chandra, Grant A. McArthur, Jeffrey Sosman

Pages 1087-1108

Cytokines (IL-2, IFN, GM-CSF, etc.) Melanoma

John B. A. G. Haanen, Ryan J. Sullivan, John M. Kirkwood, Michael B. Atkins, Douglas J. Schwartzentruber

Pages 1109-1140

Checkpoint Inhibitors in the Treatment of Metastatic Melanoma

Alison Weppler, Peter Lau, Grant A. McArthur

Pages 1141-1164

Novel Immunotherapies and Novel Combinations of Immunotherapy for Metastatic Melanoma

Daniel J. Olson, Rodolfo Gutierrez, Salah Eddine Bentebibel, Randy F. Sweis, Omid Hamid, Adi Diab et al.

Pages 1165-1186

Management of Distant Metastases

Managing Checkpoint Inhibitor Symptoms and Toxicity for Metastatic Melanoma

Anna Pavlick, Jeffrey Weber

Pages 1187-1214

Sequencing and Combinations of Molecularly Targeted and Immunotherapy for BRAF-Mutant Melanoma

Paolo A. Ascierto, Michael B. Atkins

Pages 1215-1241

Melanoma Vaccines

Peter Hersey, Stuart J. Gallagher, John M. Kirkwood, Jonathan Cebon

Pages 1243-1265

Cellular Therapy for Melanoma

Udai S. Kammula, Michael T. Lotze

Pages 1267-1299

Systemic Therapy for Mucosal, Acral, and Uveal Melanoma

Suthee Rapisuwon, Yong Qin, Jason Roszik, Fernando Carapeto, Sapna Patel, Richard D. Carvajal

Pages 1301-1335

Dermatological Complications of Systemic Therapies for Melanoma

Egle Ramelyte, Reinhard Dummer, Cristina Libenciuc, Gregory S. Phillips, Mario E. Lacouture, Caroline Robert

Pages 1337-1358

Surgical Management of Distant Melanoma Metastases

John F. Thompson, Mark B. Faries, Erica B. Friedman, Jeffrey E. Lee, Charles M. Balch

Pages 1359-1402

Radiotherapy for Distant Melanoma Metastases

Angela M. Hong, Christopher A. Barker

Pages 1403-1420

Melanoma Brain Metastases: Unique Biology and Implications for Systemic Therapy

Kim Margolin, Michael Davies, Harriet Kluger, Hussein Tawbi

Pages 1421-1454

History of Melanoma

Front Matter

Pages 1455-1455

A History of Melanoma: From Hunter to Morton

Arthur J. Sober, Charles M. Balch, John F. Thompson, John M. Kirkwood

Pages 1457-1475

Back Matter

Pages 1477-1510