Practical Medical Oncology Textbook

Didactically structured with a wealth of figures, schemes, tables and diagrams to foster the learning process

Summarizes clinical recommendations from the main international guidelines

Includes expert tips and comments in text boxes with key points, hints for deeper insight and suggested further reading

Discusses clinical cases for all tumor types described

About this book

  This textbook combines essential information on clinical cancer medicine with a guide to the latest advances in molecular oncology and tumor biology. Providing a systematic overview of all types of solid tumors, including epidemiology and cancer prevention, genetic aspects of hereditary cancers, differential diagnosis, typical signs and symptoms, diagnostic strategies and staging, and treatment modalities, it also discusses new and innovative cancer treatments, particularly targeted therapy and immunotherapy. Expert commentaries at the end of each chapter highlight key points, offer insights, suggest further reading and discuss clinical application using case descriptions. This textbook is an invaluable, practice-oriented tool for medical students just beginning their clinical oncology studies, as well as for medical oncology residents and young professionals.

Editors and Affiliations

Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy

Antonio Russo

Oncology Department, University of Antwerp, Edegem, Belgium

Marc Peeters

Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy

Lorena Incorvaia

Center for Thoracic Oncology, Tisch Cancer Institute, Mount Sinai System & Icahn School of Medicine, Mount Sinai, USA

Christian Rolfo

Table of contents (60 chapters)

From Basic Research to Cancer Diagnosis

Epidemiology and Cancer Prevention

Francesco Vitale, Lucia Mangone

Pages 3-13

Tumor Biology and Natural History

Daniele Fanale, Juan Lucio Iovanna, Antonio Giordano, Antonio Russo, Viviana Bazan

Pages 15-31

Histopathology of the Tumors

Giancarlo Troncone, Elena Vigliar

Pages 33-41

Biomarkers

Fiorella Guadagni, Sofia Cutaia, Giorgio Madonia, Valerio Gristina, Lorena Incorvaia, Lidia Rita Corsini

Pages 43-64

Hereditary Cancers and Genetics

Daniele Fanale, Laura Ottini, Enrico Ricevuto, Valerio Gristina, Valentina Calò, Lorena Incorvaia

Pages 65-98

Liquid Biopsy

Marta Castiglia, Lorena Incorvaia, Valerio Gristina, Umberto Malapelle, Viviana Bazan, Christian Rolfo

Pages 99-122

Diagnosis and Staging

Mauro Cives, Marco Tucci, Franco Silvestris

Pages 123-135

Molecular Diagnostics: Innovative Technologies for Clinical and Translational Research

Marta Castiglia, Francesco Pepe, Alessandro Perez, Umberto Malapelle

Pages 137-151

Principles of Cancer Therapeutics

Chemotherapy

Antonino Grassadonia, Davide Brocco, Clara Natoli, Nicola Tinari

Pages 155-168

Endocrine Therapy

Francesco Schettini, Giuseppe Buono, Mario Giuliano, Grazia Arpino, Sabino De Placido

Pages 169-180

Targeted Therapy

Maurizio D’Incalci, Elena Monti, Lorena Incorvaia, Marta Castiglia, Antonio Russo, Viviana Bazan

Pages 181-206

Immunotherapy

Andrea Botticelli, Claudia Trojaniello, Paolo A. Ascierto, Paolo Marchetti

Pages 207-223

Integrated Treatments: The Role of Surgery

Salvatore Gruttadauria, Duilio Pagano, Alessandro Bertani

Pages 225-235

Integrated Treatments: The Role of Radiotherapy

Ivan Fazio, Carla Germana Rinaldi, Filippo Alongi, Antonella Mazzonello, Manuela Federico, Sara Ramella

Pages 237-248

Response Assessment to Cancer Therapy

Massimo Midiri, Patrizia Toia, Giuseppe La Tona, Massimo Galia, Giuseppe Lo Re

Pages 249-257

Clinical Trials and Methodology of Cancer Research

Massimo Di Maio, Francesco Perrone

Pages 259-267

Basic Principles of Bioinformatics for Next-Generation Sequencing Molecular Testing in Oncology

Simona De Summa, Stefania Tommasi

Pages 269-279

Principles of Cancer Therapeutics

New Drugs Development

Paolo G. Casali

Pages 281-287

Management of Adverse Effects and Post Treatment Considerations

Treatment Toxicity

Tindara Franchina, Giuseppina Rosaria Rita Ricciardi, Alessandro Russo, Vincenzo Adamo

Pages 291-308

Cardio-Oncology

Giuseppina Novo, Lorena Incorvaia, Laura Ajello, Enrico Bronte, Puja Mehta, Susmita Parashar

Pages 309-325

Cancer Cachexia

Iñaki Eguren-Santamaría, Carlos Centeno, Ignacio Gil-Bazo

Pages 327-347

Supportive and Palliative Care

Fabio Fulfaro

Pages 349-356

Patient–Physician Communication

Elisabetta Razzaboni

Pages 357-364

Bone Health in Cancer Patients

Daniele Santini, Giulia Ribelli, Sonia Simonetti, Michele Iuliani, Francesco Pantano, Giuseppe Tonini

Pages 365-380

Nutrition and Cancer

Daniele Fanale, Lorena Incorvaia, Antonio Russo, Valter D. Longo, Mario G. Mirisola

Pages 381-389

Personalized Medicine

Pierosandro Tagliaferri, Pierfrancesco Tassone

Pages 391-399

Tumor Board and Molecular Tumor Board

Lorena Incorvaia, Maria La Mantia, Giorgio Madonia, Daniele Fanale, Valerio Gristina, Viviana Bazan

Pages 401-409

Precision Medicine in Oncology: Glossary of Relevant Scientific Terms

On behalf of the AIOM – SIAPEC – SIBIOC – SIF Working Group, Stefania Gori, Lorena Incorvaia, Mauro Truini, Antonio Marchetti, Ettore Domenico Capoluongo

Pages 411-416

Patients Categorization

Paolo Tralongo, Francesca Caspani, Antonino Carmelo Tralongo, Antonella Surbone

Pages 417-424

Clinical Oncology: Diagnosis and Treatment of Solid Tumors

Locoregional and Locally Advanced Breast Cancer

Gaia Griguolo, Maria Vittoria Dieci, Valentina Guarneri, Pier Franco Conte

Pages 429-466

Metastatic Breast Cancer

Giuseppe Buono, Francesco Schettini, Grazia Arpino, Mario Giuliano, Sabino De Placido

Pages 467-479

Lung Cancer

Francesco Passiglia, Valerio Gristina, Christian Rolfo, Nadia Barraco, Viviana Bazan, Antonio Russo

Pages 481-515

Malignant Pleural Mesothelioma

Enrica Capelletto, Silvia Novello

Pages 517-538

Cancer of the Esophagus

Eugenio Fiorentino, Angelica Petrillo, Luca Pompella, Ina Macaione, Ferdinando De Vita

Pages 539-558

Gastric Cancer: Locoregional Disease

Valerio Gristina, Nadia Barraco, Antonio Galvano, Daniele Fanale, Maria La Mantia, Marc Peeters

Pages 559-585

Clinical Oncology: Diagnosis and Treatment of Solid Tumors

Gastric Cancer: Advanced/Metastatic Disease

Ferdinando De Vita, Giuseppe Tirino, Luca Pompella, Angelica Petrillo

Pages 587-604

Colorectal Cancer: Locoregional Disease

Erika Martinelli, Claudia Cardone, Giulia Martini

Pages 605-616

Colorectal Cancer: Metastatic Disease

Antonio Galvano, Aurelia Ada Guarini, Valerio Gristina, Nadia Barraco, Maria La Mantia, Marta Castiglia

Pages 617-633

Anal Cancer

Antonio Galvano, Aurelia Ada Guarini, Valerio Gristina, Maria La Mantia, Antonio Russo

Pages 635-644

Cancer of Exocrine Pancreas

Daniele Fanale, Giorgio Madonia, Antonio Galvano, Marc Peeters, Albert J. ten Tije, Juan Lucio Iovanna

Pages 645-674

Biliary Cancer

Giuseppe Tonini, Michele Iuliani, Giulia Ribelli, Sonia Simonetti, Francesco Pantano

Pages 675-688

Hepatocellular Cancer

Riccardo Memeo, Patrick Pessaux, Nicola Silvestris, Oronzo Brunetti, Antonio Giovanni Solimando, Andrea Casadei Gardini

Pages 689-706

Head and Neck Cancers

Carlo Resteghini, Donata Galbiati, Giuseppina Calareso, Nicola Alessandro Iacovelli, Alberto Paderno, Cesare Piazza

Pages 707-729

Central Nervous System Malignancies

Giuseppe Badalamenti, Massimiliano Cani, Lidia Rita Corsini, Lorena Incorvaia, Alessandro Inno, Stefania Gori

Pages 731-754

Renal Cancer

Lorena Incorvaia, Giuseppe Procopio, Camillo Porta

Pages 755-774

Bladder Cancer

Hector Josè Soto Parra, Fiorenza Latteri, Laura Noto, Marco Maria Aiello

Pages 775-790

Prostate Cancer: Locoregional Disease

Roberto Iacovelli, Claudia Mosillo, Chiara Ciccarese, Renzo Mazzarotto, Maria Angela Cerruto

Pages 791-803

Prostate Cancer: Advanced and Metastatic Disease

Roberto Iacovelli, Raffaele Ratta, Chiara Ciccarese, Emanuela Fantinel, Davide Bimbatti, Elena Verzoni

Pages 805-821

Testicular Cancer

Andreia Coelho, Patricia Gago, Miguel Barbosa, Antonio Teira

Pages 823-834

Cancer of the Penis

Alchiede Simonato, Cristina Scalici Gesolfo, Alberto Abrate

Pages 835-842

Ovarian Cancer, Early Primary Disease

Domenica Lorusso, Giuseppa Maltese, Ilaria Sabatucci, Elisa Tripodi

Pages 843-859

Ovarian Cancer: Primary Advanced and Recurrent Disease

Domenica Lorusso, Giuseppa Maltese, Lorena Incorvaia, Ilaria Sabatucci, Stefano Lepori

Pages 861-883

Endometrial and Cervical Cancers

Lorena Incorvaia, Luisa Castellana, Lavinia Insalaco, Giuseppa Maltese, Domenica Lorusso

Pages 885-922

Vulvar and Vaginal Cancers

Nicla La Verde, Aurelia Ada Guarini, Lavinia Insalaco, Domenica Lorusso

Pages 923-932

Cancer of the Adrenal Gland

Mélanie Claps, Deborah Cosentini, Elisa Roca, Alfredo Berruti

Pages 933-955

Clinical Oncology: Diagnosis and Treatment of Solid Tumors

Cancer of the Thyroid

Valerio Gristina, Nadia Barraco, Silvio Buscemi, Lorena Incorvaia, Alfredo Berruti

Pages 957-978

Cutaneous Melanoma and Other Skin Cancers

Paola Queirolo, Andrea Boutros, Enrica Teresa Tanda

Pages 979-1007

Soft Tissue Sarcomas (STS)

Giuseppe Badalamenti, Bruno Vincenzi, Massimiliano Cani, Lorena Incorvaia

Pages 1009-1020

Gastrointestinal Stromal Tumors (GISTs)

Lorena Incorvaia, Giuseppe Badalamenti, Sergio Rizzo, Viviana Bazan, Antonio Russo, Alessandro Gronchi

Pages 1021-1059

Neuroendocrine Neoplasms (NENs)

Nicola Fazio, Francesca Spada, Roberta Elisa Rossi, Valentina Ambrosini, Lorena Incorvaia, Francesco Passiglia

Pages 1061-1089