Stroke Revisited: Pathophysiology of Stroke: From Bench to Bedside

Description:

This book presents state of the art knowledge on stroke pathophysiology, covering both basic and clinical aspects in detail. Readers will find up-to-date information on hemodynamics, cerebral vessel degeneration, cell death, and neurorepair. The mechanisms and clinical manifestations of large artery atherosclerosis, small vessel disease, and cardioembolism are extensively discussed, and the relation between specific conditions and stroke is explored. The book has a unique organizational style, with inclusion of historic experimental and clinical study results. The numerous photos and illustrations will facilitate understanding of practical aspects and rapid retrieval of fundamental information. As comprehension of stroke pathophysiology has deepened, a variety of drugs for stroke treatment have been developed and tested, and in recent years much research has focused on neurorestorative therapy using stem cells. It therefore seems timely to bring together within one volume the most important current knowledge on stroke pathophysiology. The book will be invaluable for stroke physicians, surgeons, and students alike.

Table of Contents:

Part I. Introduction on Stroke

1. General Facts of Stroke

2. Cerebral Vascular Anatomy

Part II. Clinical Science: Large Artery Atherothrombosis

3. Concept of Large Artery and Small Vessel

4. Pathophysiology of Large-Artery Atherosclerosis

5. Pathophysiology of Stroke Resulting from Large-Artery Atherothrombosis

Part III. Clinical Science: Small Vessel Disease

6. Cerebral Small Vessel Disease

7. Cerebral Amyloid Angiopathy: Emerging Evidence for Novel Pathophysiology and Pathogenesis

8. Cerebral Autosomal Dominant Arteriopathy with Subcortical Ischemic Strokes and Leukoencephalopathy (CADASIL)

Part IV. Clinical Science: Cardioembolism

9. Pathophysiology of Cardioembolism

10. Atrial Fibrillation and Other Cardiac Dysfunctions Related with Stroke

Part V. Clinical Science: Pathophysiology of Specific Causes

11. Cerebral Vessel Wall Diseases

12. Hemorrheologic Disease

13. Paradoxical Embolic Stroke

14. Hemorrhagic Diseases

Part VI. Brain Hemodynamics

15. Brain Hemodynamics

Part VII. Basic Aspect: Cell Death and Neurorepair

16. Pathophysiology of Neuronal Cell Death After Stroke

17. Emerging Mechanism of Cell Death Caused by Stroke: A Role of Neurovascular Unit

18. Basic Aspect: Neurorepair After Stroke

19. Mechanism of Recovery After Stroke

20. Neurorepair Strategies After Stroke

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