Parkinson Disease,An Issue of Clinics in Geriatric Medicine (Volume 36-1)

·  Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology

·  Key points

·  Introduction

·  Neuropathology

·  Epidemiology

·  Genetics and pathophysiology

·  Alpha-synuclein aggregation and spread of pathology

·  Summary

·  Diagnosis and Differential Diagnosis of Parkinson Disease

·  Key points

·  Introduction

·  Parkinson disease

·  Multiple system atrophy

·  Progressive supranuclear palsy

·  Corticobasal degeneration

·  Dementia with Lewy bodies

·  Vascular parkinsonism

·  Summary

·  Disclosure

·  Does This Patient Have Parkinson Disease or Essential Tremor?

·  Key points

·  Just when you thought you could distinguish Parkinson disease from essential tremor

·  Some other types of tremor in the elderly

·  Management of Early Parkinson Disease

·  Key points

·  Introduction

·  Early Parkinson disease

·  Pharmacologic agents for early Parkinson disease

·  Treatment strategies in early Parkinson disease

·  Levodopa: early versus delayed use

·  Nonmotor symptoms

·  Surgical treatment of Parkinson disease

·  Exercise in Parkinson disease

·  Summary

·  Management of Motor Features in Advanced Parkinson Disease

·  Key points

·  Introduction

·  Defining fluctuations and dyskinesias

·  Treatment of motor fluctuations associated with levodopa treatment

·  Treatment of dyskinesias associated with levodopa treatment

·  Advanced treatments of Parkinson disease

·  Management of motor symptoms refractory to dopaminergic therapy

·  Summary

·  Orthostatic Hypotension in Parkinson Disease

·  Key points

·  Introduction

·  Epidemiology

·  Pathophysiology

·  Approach to the patient with orthostatic hypotension

·  Diagnosis of neurogenic orthostatic hypotension

·  Management of neurogenic orthostatic hypotension

·  Neurogenic supine hypertension

·  Summary

·  Management of Urologic and Sexual Dysfunction in Parkinson Disease

·  Key points

·  Introduction

·  Anatomy/pathophysiology

·  Management of urinary symptoms

·  Management of disorders of sexual performance

·  Management of disorders of sexual desire (libido)

·  Summary

·  Gastrointestinal Care of the Parkinson Patient

·  Key points

·  Introduction

·  Weight loss

·  Drooling

·  Dysphagia

·  Gastroparesis

·  Defecatory dysfunction

·  Constipation

·  Effects of Parkinson disease therapies on gastrointestinal symptoms

·  Summary

·  Depression and Anxiety in Parkinson Disease

·  Key points

·  Introduction

·  Epidemiology

·  Classification

·  Risk factors for depression and anxiety

·  Scales

·  Pharmacologic intervention

·  Optimizing dopaminergic treatment

·  Nonpharmacologic therapy

·  Management of anxiety

·  Summary

·  Hallucinations, Delusions and Impulse Control Disorders in Parkinson Disease

·  Key points

·  Introduction

·  Approach to compulsive and psychotic symptoms in Parkinson disease

·  Delirium in Parkinson disease

·  Chronic psychosis in Parkinson disease

·  Impulse control disorders in Parkinson disease

·  Summary

·  Overview of Sleep and Circadian Rhythm Disorders in Parkinson Disease

·  Key points

·  Introduction

·  Most common sleep disorders associated with Parkinson disease

·  Summary

·  Orthopedic Care of Patients with Parkinson Disease

·  Key points

·  Introduction

·  Causes of fall-related fractures in Parkinson disease

·  Orthopedic interventions for shoulder problems in Parkinson disease

·  Spine surgery in Parkinson disease

·  Knee and hip surgery in Parkinson disease

·  Cognitive decline and orthopedic surgeries in patients with Parkinson

·  Summary

·  Driving in Parkinson Disease

·  Key points

·  Epidemiology of driving issues in Parkinson disease

·  Neurological substrates of driving issues

·  Naturalistic studies

·  Simulator studies

·  Road studies

·  Driving rehabilitation

·  Policy issues

·  Future of driving in Parkinson disease

·  Summary

·  Palliative Care for Parkinson Disease

·  Key points

·  Relevance of palliative care to Parkinson disease

·  Summary

·  Multidisciplinary Care to Optimize Functional Mobility in Parkinson Disease

·  Key points

·  Introduction

·  Assessment of functional mobility

·  Multidisciplinary management to improve functional mobility

·  Organization of multidisciplinary care

·  Summary

·  Hospital Management of Parkinson Disease Patients

·  Key points

·  Introduction

·  Causes of urgent and elective hospitalization in patients with Parkinson disease

·  Care of patients with Parkinson disease in the hospital setting

·  Perioperative care

·  Strategies to minimize hospitalization in Parkinson disease

·  Palliative care