For more than 30 years, Perez and Brady's Principles and Practice of Radiation Oncology has been the must-have standard reference for radiation oncologists and radiation oncology residents who need a comprehensive text covering both the biological and physical science aspects of this complex field as well as disease site-specific information on the integrated, multidisciplinary management of patients with cancer.

The book has established itself as the discipline’s "text-of-record," belonging on the shelf of all of those working in the field. The Seventh Edition continues this tradition of excellence with extensive updates throughout, many new chapters, and more than 1,400 full-color illustrations that highlight key concepts in tumor pathogenesis, diagnosis, and targeted radiation therapy.

•         Comprehensive coverage of the current state of knowledge of cancer biology; medical radiation physics; clinical radiation oncology; and radiation oncology economics, ethics, and public policy.

•         Regular, twice-yearly content updates available with the digital version of the text.

•         Ideal for radiation oncologists, radiation oncology residents, radiation biologists, medical radiation physicists, oncologists, physicists-in-training, radiation dosimetrists, and nurses and physician assistants working in radiation oncology departments.

•         New chapters include: Proton and Carbon Ion Beam Dosimetry and Treatment Planning; Stereotactic Radiation Therapy; Re-Irradiation; Error Avoidance; Undergraduate, Graduate, and Continuing Medical Education in Radiation Oncology; and a completely rewritten chapter on the economics of radiation oncology.

•         Designed to provide a better understanding of the natural history of cancer, the physical and technological methods of radiation application, the effects of irradiation on normal tissues, and the most judicious ways in which radiation therapy can be employed in the treatment of patients with cancer, either as a single modality or as part of a multi-modality treatment program.

•         All references printed in the book are now streamlined for quick access to further information.

•         Site-specific chapters include relevant background information on each tumor—including epidemiology, pathology, diagnostic work-up, prognostic factors, treatment techniques, applications of surgery, chemotherapy, immunotherapy and biological therapy, end results, and more.

•         Increased focus on new approaches and technologies with new and updated chapters.

•         Greater emphasis on palliative and supportive care reflects the role of radiation treatment in non-curative roles.

•         An international group of expert chapter authors keeps you well-informed.

•         A completely revised first chapter is designed to provide an overview of the discipline of radiation oncology. This will be particularly useful for residents beginning training and medical students beginning a radiation oncology clinical clerkship. The chapter is supplemented with multiple sidebars to augment the reader's understanding of the field.

•        

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•         Customize for your language, including right-to-left reading, vertical writing, and enhanced annotation in over 30 languages

•         Easily convert to audiobook, powering your content with natural language text-to-speech

•         Adapt for unique reading needs, supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more

 Highly specialized structures, microanatomy of individual components, and overall structural density make the head and neck one of the most challenging areas in radiology. Imaging Anatomy: Head and Neck provides radiologists, residents, and fellows with a truly comprehensive, superbly illustrated anatomy reference that is designed to improve interpretive skills in this complex area. A wealth of high-quality, cross-sectional images, corresponding medical illustrations, and concise, descriptive text offer a unique opportunity to master the fundamentals of normal anatomy and accurately and efficiently recognize pathologic conditions.

Improved surgical techniques and increasing patient expectations have transformed the field of cosmetic facial surgery, and Art and Science of Facelift Surgery brings you up to speed with today’s best and latest procedures. This highly practical resource features a superbly illustrated print reference with step-by-step procedures accompanied by surgical videos of each technique. Comprehensive, easy-to-follow instruction from internationally renowned expert Dr. Joe Niamtu helps you achieve optimal outcomes on frequently requested procedures.

Table Of Contents:

Chapter 1: What is a Facelift? History and Semantics 1

Chapter 2: The Aging Face 6

Chapter 3: Evaluating the Cosmetic Facial Surgery Patient:

The Art of the Consult and the Office Patient

Experience 21

Chapter 4: Facelift Instrumentation and Surgery Center 45

Chapter 5: Facelift Anatomy 53

Chapter 6: Facelift Surgery (Cervicofacial Rhytidectomy) 62

Chapter 7: Case Presentations 144

Chapter 8: Modified Facelift Procedures 160

Chapter 9: Complications of Face and Neck Lift: Recognition,

Treatment and Prevention 183

 Highly visual and packed with useful, practical information, Atlas of Endovascular Venous Surgery, 2nd Edition, provides real-world instruction on the evaluation, diagnostic imaging, and medical and endovascular surgical management of acute and chronic venous diseases. Dr. Jose Almeida, pioneering expert in the field and host of the annual International Vein Congress, along with other highly regarded practitioners, offers an authoritative understanding of what causes increased venous pressure and solutions for reducing venous hypertension. Detailed, full-color intraoperative illustrations capture key teaching moments, helping you better understand the nuances of surgery and improve your ability to perform cutting-edge procedures.

Features:

•             Uses full-color line art to depict key anatomic features and anatomic approaches to venous surgeries, providing you with an overview of the relevant clinical anatomy for each procedure.

•             Shows the correlation between radiologic appearance (ultrasound, CT, MRI) and anatomic and surgical views.

•             Accompanies each surgical procedure with concise, descriptive text, giving you a step-by-step "walk through" of each technique. High-quality intraoperative videos demonstrate key stages of intraoperative technique.

•             Ideal for all practitioners who treat patients with venous disorders, including vascular and general surgeons as well as interventional radiologists.

New To This Edition:

•             Reflects the many developments that have taken place in the treatment of the deep venous system, especially the use of new anticoagulants and techniques to treat the sequelae of acute and chronic venous thromboembolic disease.

•             Includes five brand-new chapters covering venous hemodynamics; new concepts in the management of pulmonary embolus; endothermal heat induced thrombosis; deep venous incompetence and valve repair; and nutcracker syndrome.

•             Features significant updates throughout, including new devices in the management of thromboembolic disease; aggressive techniques for recanalizing iliofemoral venous occlusions, new nomenclature and endovascular approach to the treatment of pelvic venous disorders, new non-thermal devices for saphenous vein ablation, new stents for treatment of iliac vein obstruction and new devices for clot management, and endovascular and open repair of deep vein obstruction and reflux.

•             Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

 •             Includes complete information for each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, epidemiology, and public health and regulatory issues - plus complete information for each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies.

•             Analyzes the cost-benefit and cost-effectiveness of different vaccine options.

•             Helps you clearly visualize concepts and objective data through an abundance of tables and figures.

New To This Edition:

•             Covers the new oral cholera and zoster vaccines, as well as newly licensed meningococcal group B vaccines and a newly licensed dengue vaccine.

•             Brings you up to date on successful human trials of Ebola vaccines, an enterovirus 71 vaccine licensed in China, and new recommendations and changes to polio vaccines.

•             Features a new chapter on maternal immunization.

•             Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Written by an international team of authors specializing in microbiology and infectious disease, this new edition of Evidenced-based Infectious Diseases presents practical, up-to-date information on the care of individual patients suffering from infectious diseases. Each chapter addresses a series of focused clinical questions addressed in a systematic fashion, including a comprehensive literature search, and a rating of the quality of evidence using principles of the GRADE framework. Evidence-Based Infectious Diseases is the ideal reference work for all those involved with microbiology, infectious diseases, and clinical management. 

Table of contents

List of Contributors vii

Preface xi

1 Introduction to Evidence‐based Infectious Diseases 1

Dominik Mertz, Nick Daneman, and Fiona Smaill

Part 1 Specific Diseases 11

2 Skin and Soft‐tissue Infections 13

Douglas Austgarden and Guilio DiDiodato

3 Bone and Joint Infections 23

Nora Renz and Andrej Trampuz

4 Infective Endocarditis 37

Bahareh Ghadaki and Deborah Yamamura

5 Meningitis and Encephalitis 53

Christopher E. Kandel and Wayne L. Gold

6 Community‐acquired Pneumonia 73

Mark Downing and Jennie Johnstone

7 Healthcare‐associated Pneumonia 81

Jennie Johnstone and Mark Downing

8 Tuberculosis 87

Peter Daley and Marek Smieja

9 Clostridium Difficile Infection in Adults 99

Louis Valiquette

10 Urinary Tract Infections 107

Thomas Fekete

11 Sexually Transmitted Infections 127

Courtney A. Thompson, Darrell H. S. Tan, and Kaede Sullivan

12 Human Immunodeficiency Virus (HIV) 149

Ali Amini, Monique Andersson, Ravindra Gupta, and Brian Angus

13 Hepatitis 181

Lise Bondy and Michael S. Silverman

14 Influenza 193

Ashley Roberts and Joanne M. Langley

15 Critical Care 201

Bram Rochwerg and Jocelyn A. Srigley

Part 2 Special Populations 215

16 Infection Prevention and Control 217

Graham M. Snyder and Eli N. Perencevich

17 Antimicrobial Stewardship 235

Alainna J. Jamal and Andrew M. Morris

18 Infections in Neutropenic Hosts 251

Eric J. Bow

19 Infections in General Surgery 269

Paul A. Moroz and Christine H. Lee

20 Infections in Healthcare Workers 279

Gregory W. Rose

Index 287

Perfect your lab skills with the gold standard in microbiology! Serving as both the #1 bench reference for practicing microbiologists and as a favorite text for students in clinical laboratory science programs, Bailey & Scott’s Diagnostic Microbiology, 14th Edition covers all the topical information and critical thinking practice you need for effective laboratory testing. This new edition also features hundreds step-by-step procedures, updated visuals, new case studies, and new material on the latest trends and equipment in clinical microbiology - including automation, automated streaking, MALDI-TOF, and incubator microscopes. It’s everything you need to get quality lab results in class and in clinical practice!

Features:

•             More than 800 detailed, full-color illustrations aid comprehension and help in visualizing concepts.

•             Expanded sections on parasitology, mycology, and virology eliminate the need to purchase separate books on this material.

•             General and Species boxes in the organism chapters highlight the important topics that will be discussed in the chapter.

•             Case studies provide the opportunity to apply information to a variety of diagnostic scenarios, and help improve decision-making and critical thinking skills.

•             Hands-on procedures include step-by-step instructions, full-color photos, and expected results.

•             A glossary of terms is found at the back of the book for quick reference.

•             Learning objectives begin each chapter, offering a measurable outcome to achieve by the completing the material.

•             Learning resources on the Evolve companion website enhance learning with review questions and procedures.

New To This Edition:

•             NEW! Coverage of automation, automated streaking, MALDI-TOF, and incubator microscopes keeps you in the know on these progressing topics.

•             NEW! Updated images provide a more vivid look into book content and reflect the latest procedures.

•             NEW! Thoroughly reviewed and updated chapters equip you with the most current information.

•             NEW! Significant lab manual improvements provide an excellent learning resource at no extra cost.

•             NEW! 10 extra case studies on the Evolve companion website offer more opportunities to improve critical thinking skills.

The world's leading knee reconstruction and sports medicine surgeons guide you to manage the toughest cases you'll see.

Step-by-step guidance for more than 70 advanced reconstruction techniques.

Developed in collaboration with The Knee Society, this powerful resource puts the expertise of top surgeons at your fingertips - tips, pearls, and techniques that reflect the leading edge of knee reconstruction.

Procedures are liberally illustrated with full-color intraoperative photographs. Selected techniques are enhanced with videos demonstrating pearls from master surgeons.

Techniques chapters are clearly organized for quick reference:

•         Indications

•         Contraindications

•         Alternative Treatments

•         Results

•         Technique

•         Setup and Exposure

•         Instruments, Equipment, Implants Required

•         Wound Closure

•         Postoperative Regimen

•         Avoiding Pitfalls and Complications

•         Bibliography

Major sections include:

•         Primary Total Knee Arthroplasty

•         Complex Total Knee Arthroplasty

•         Complications After Total Knee Arthroplasty

•         Revision Total Knee Arthroplasty

•         Alternative Reconstructive Procedures

Sports Medicine:

•         ACL Reconstruction

•         PCL Reconstruction

•         Collateral Ligament Reconstruction

•         Knee Dislocation

•         Meniscal Injuries

•         Patellofemoral Injuries

•         Knee and Sports Medicine

Get ready to help more and more patients stay active as you learn step-by-step from the creators of these surgical breakthroughs.

Delve deep into the complicated cases that mark your practice and manage the most formidable situations with new confidence.

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 OKU: Pediatrics 5 reflects the substantial number of high-quality studies in pediatric orthopaedics, as well as the most recent clinical practice guidelines and appropriate use criteria. This comprehensive multispecialty resource explores the latest advances in pediatric trauma, sports-related injuries, and upper and lower extremity conditions, with a brand-new section on Neuromuscular, Metabolic, and Inflammatory Disorders.

Developed in partnership with the Pediatric Orthopaedic Society of North America (POSNA), this concentrated guide to new techniques, new approaches, and current controversies is ideal for anyone who treats pediatric musculoskeletal injuries.

Recognized section editors and contributors bring fresh approaches and perspectives, with a focus on delivering a well-rounded update of this rapidly evolving subspecialty.

Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities!

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•         Adapt for unique reading needs, supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more

Introducing the book that bridges the gap between a dermatologic surgery textbook and a dedicated flap and reconstructive guide

Dermatologic Surgery is a unique resource that offers the benefits of both a single-volume multi-author global dermatologic surgery textbook and a dedicated flap and reconstructive reference. Conveniently organized by flap type as well as regional approach, it offers by far the most comprehensive flap and reconstruction sections of any general dermatologic surgery book.

The book’s content breakdown attempts to reflect the proportion of time, effort, and training required for a given subject. For example, there are five full chapters (in addition to numerous other sections) dedicated to Mohs surgery. Similarly, a total of 17 richly illustrated chapters, including those devoted to particular flap techniques and regional approaches to reconstruction, address flap and graft closures. Since anatomy is the foundation on which all surgery is built, the anatomy chapter was built on a true ground-up cadaveric study of head and neck anatomy with an eye to clinical relevance.

Full-length high-quality videos are an essential adjunct to learning procedural techniques, and this text includes the largest video resource of its kind ever compiled. This coupled with almost 3, 000 high-quality clinical photographs and nearly 500 professional medical illustrations, including infographics with surgical pearls for each chapter – many bolstered by beginner tips, expert tips, cautions, patient education points, and even billing tips – make this a true primer for real-world skin surgery practice.

 Paediatric patients with neurological problems are a special population. Managing these patients requires special anaesthetic considerations and a detailed book is much needed. This book is a comprehensive reference book and includes topics ranging from basic sciences (neuroanatomy, neurophysiology, and neuropharmacology) to special situations such as brain death, ethical issues, and palliative care. Besides the chapters dealing with various neurological surgical problems, there is a dedicated section on common procedures performed on paediatric patients in the operation theatre and ICUs, such as insertion of venous cannula, arterial line, central line, etc., all of which are challenging. This section is supported by tutorial videos. The fact that basic sciences are included along with clinical sciences makes it unique and helpful for the readers.

 •             An MRI-based guide, followed by laparoscopic and histopathological correlations

•             Intended for radiologists, gynaecologists and all other professionals interested in deep endometriosis

•             Features a wealth of images, addressing the most important radiological aspects of deep endometriosis

About this book

This Atlas presents an MRI-based guide to the diagnosis, treatment and follow up of deep endometriosis. Developed by professionals with a extensive clinical experience in the diagnosis and treatment of deep endometriosis, it provides a global overview of the disease, from basic clinical aspects of imaging diagnosis, to the correlation with surgical findings and histopathological results.

Deep endometriosis is a serious gynecological condition, which can severely impact on women’s quality of life. It shares the main features of regular endometriosis, but also displays a highly infiltrative pattern, involving multiple organs and leading to severe symptoms such as dysmenorrhea, chronic pelvic pain and dyspareunia.  Atlas of Deep Endometriosis – MRI and Laparoscopic Correlations is a complete guide, intended for radiologists, gynecologists and all other medical professionals interested on the diagnosis and treatment of deep endometriosis.

Long considered one of ophthalmology's premier texts, this award-winning title by Drs. Myron Yanoff and Jay S. Duker remains your go-to reference for virtually any topic in this fast-changing field. In a single, convenient volume, it offers detailed, superbly illustrated guidance on nearly every ophthalmic condition and procedure you may encounter, making it a must-have resource no matter what your level of experience. Extensive updates throughout keep you current with all that's new in every subspecialty area of the field.

Offers truly comprehensive coverage, including basic foundations through diagnosis and treatment advances across all subspecialties: genetics, optics, refractive surgery, lens and cataract, cornea, retina, uveitis, tumors, glaucoma, neuro-ophthalmology, pediatric and adult strabismus, and oculoplastics.

Features streamlined, templated chapters, a user-friendly visual layout, and key features boxes for quick access to clinically relevant information and rapid understanding of any topic.

Contains nine brand-new chapters covering OCT angiography and optical coherence tomography, small incision lenticule extraction (SMILE), corneal imaging, electrophysiology in neuro-ophthalmology, glaucoma drainage implants, thyroid eye disease, orbital infections, and aesthetic fillers and botulinum toxin for wrinkle reduction.

Covers new imaging techniques including wide-field imaging, anterior segment OCT (AS-OCT), and high definition OCT, as well as two completely reorganized sections on optics and refraction and intraocular tumors that provide a more logical and user-friendly approach for enhanced understanding.

Includes more than 2,000 high-quality illustrations (most in full color) and an expanded video library with 50 clips of diagnostic and surgical techniques. New videos cover refractive surgery advances, phakic intraocular lenses, combined cataract procedures, nystagmus, eye movement examinations, and more.

Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Dr. Richard Polin's Neonatology Questions and Controversies 7-volume series highlights the most challenging aspects of neonatal care, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today's practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient.

Stay fully up to date in this fast-changing field with seven comprehensive volumes in the Neonatology Questions and Controversies series.

Each volume provides expert guidance on key challenges facing practitioners in clinical settings.

Updated editions (including one entirely new volume on Infectious Disease and Pharmacology) highlight new information on genetics and pharmacology, two increasingly important areas in neonatology.

New topics include the molecular basis for genetic disorders, new strategies for genetic diagnosis (such as whole exome sequencing and microarrays), antenatal genetic testing, CRISPR technology for removing harmful genes, ethical conundrums and genetic counselling, and much more new content throughout every volume.

Consistent chapter organization to help you find information quickly and easily.

The most authoritative advice available from world-class neonatologists who share their knowledge of new trends and developments in neonatal care.

Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Purchase each volume individually, or get the entire 7-volume set, which includes online access that allows you to search across all titles! Gastroenterology and Nutrition Hematology, Immunology and Genetics Hemodynamics and Cardiology Infectious Disease and Pharmacology New Volume! Nephrology and Fluid/Electrolyte Physiology Neurology The Newborn Lung

Written by experts in the field of pharmacovigilance and patient safety, this concise resource provides a succinct, easy-to-digest overview of an increasingly critical area of medical safety. Drs. Thao Doan, Cheryl Renz, Fabio Lievano, Mondira Bhattacharya, and Linda Scarazzini provide essential information for health care professionals, clinical researchers, and regulators who need a comprehensive, up-to-date source of information on the principles and practice of pharmacovigilance.

Features:

•             Covers the evolving regulatory landscape, as well as current and future use of digital technologies.

•             Uses case studies to ensure content is relevant to everyday practice.

•             Discusses behavioral science and patient perspectives, risk communication, and new frontiers in pharmacovigilance.

•             Consolidates today’s available information on this timely topic into one convenient resource.

Table Of Contents:

Introduction

Section I. The Regulatory Enviroment

1. Does Regulation Drive Science or Does Science Drive Regulation?

Section II. Data and Real World Evidence

2. Role of Epidemiology in Pharmaceutical Industry

3. Real World Epidemiologic Studies and Patient Registries

Section III. Benefit-Risk in the Drug Development Life Cycle

4. Signal Management and Methods of Signal Detection

5. Causality Assessment and Examples of Adverse Drug Reactions (Drug Induced Liver Injury, Skin, Major Adverse Cardiac Events and Renal)

6. Product Safety Monitoring in Clinical Trials

7. Benefit-Risk Assessments

8. Communicating benefit risk

9. Pharmacovigilance and Medical Devices

10. Vaccine Safety Surveillance

11. Pharmacovigilance in Special Populations (Pediatrics and Elderly)

12. Pharmacovigilance in Pregnancy

Section IV. The Role of the Digital Revolution

13. Impact and Implications of Technology on Pharmacovigilance

Section V. The Next Frontier

14. The Future of Pharmacovigilance

 The only anatomy atlas illustrated by physicians, Atlas of Human Anatomy, 7th edition, brings you world-renowned, exquisitely clear views of the human body with a clinical perspective. In addition to the famous work of Dr. Frank Netter, you’ll also find nearly 100 paintings by Dr. Carlos A. G. Machado, one of today’s foremost medical illustrators. Together, these two uniquely talented physician-artists highlight the most clinically relevant views of the human body. In addition, more than 50 carefully selected radiologic images help bridge illustrated anatomy to living anatomy as seen in everyday practice.

New to this edition

Updates to the 7th Edition - based on reader requests:

Full downloadable image bank, now with on/off functionality for individual labels, available at NetterReference.com.

New Systems Overview section featuring brand-new, full-body views of surface anatomy, vessels, nerves, and lymphatics.

More than 25 new illustrations by Dr. Machado, including the clinically important fascial columns of the neck, deep veins of the leg, hip bursae, and vasculature of the prostate; and difficult-to-visualize areas like the infratemporal fossa.

New Clinical Tables at the end of each regional section that focus on structures with high clinical significance. These tables provide quick summaries, organized by body system, and indicate where to best view key structures in the illustrated plates.

More than 50 new radiologic images - some completely new views and others using newer imaging tools - have been included based on their ability to assist readers in grasping key elements of gross anatomy.

Updated terminology based on the international anatomic standard, Terminologia Anatomica, with common clinical eponyms included.

Purchase of this Professional Edition allows access to the full downloadable image bank of the current Atlas as well as additional plates from previous editions and other bonus content at NetterReference.com. [*Your Registered User License allows for the creation of presentations for your individual, personal use which you can present in small group settings of 10 or fewer people. It also permits registered student users to include images in posters at scientific conferences as long as proper citation is included. Complete Registered User License as well as contact information for Institutional sales can be found at www.NetterReference.com.] Access will terminate 5 years from publication or upon publication of the next edition of this title.

• Nearly 1, 000 state-of-the-art illustrations—all created by esteemed professors of medical illustration at Johns  Hopkins  University—are designed to help surgeons visualize the procedure as they step to the operating table

• Comprehensive coverage encompassing 62 must-know procedures, each of which is fully explained with high-yield  text and accompanying illustrations

• Consistent format includes Indications, Preoperative Preparation, Anesthesia, Position, Incision and Exposure, Closure, and Postoperative Care

• Section on minimally invasive pediatric surgery examines the latest procedural approaches to this critical surgical  area

Introducing the most essential all-in-one MIS tutorial and atlas for 21st-century practice

If you are a laparoscopic surgeon who strives to be at the vanguard of clinical practice, your atlas has arrived. Overflowing with nearly 1, 000 beautifully rendered, medically accurate illustrations, The Atlas of Minimally Invasive Surgical Operations is the definitive laparoscopic surgery procedural primer and visual roadmap.

This indispensable, one-stop resource delivers easy-to-follow procedural guidance that builds on the vital work of laparoscopic surgery pioneers at OHSU and other leading academic centers in the United States who have adapted common open operations to an MIS environment. Accompanying this skill-sharpening content are detailed illustrations that take you through each step to consider while performing current minimally invasive techniques.

 MASTER MODERN MEDICINE!

Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine

The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms.

Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible.

Essential for practice and education, the landmark 20th Edition features:

•                     Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care.

•                     State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals.

•                     All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine— Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine.

•                     Important and timely new chapters—such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more—offer the very latest, definitive perspectives on must-know topics in medical education and practice. 

•                     Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes.

•                     End-of-chapter suggested readings reinforcement

 This book provides the reader with up-to-date information on important advances in the understanding of breast cancer and innovative approaches to its management. Current and emerging perspectives on genetics, biology, and prevention are first discussed in depth, and individual sections are then devoted to pathology, imaging, oncological surgery, plastic and reconstructive surgery, medical oncology, and radiotherapy. In each case the focus is on the most recent progress and/or state of the art therapies and techniques. Further topics to receive detailed consideration include particular conditions requiring multidisciplinary approaches, the investigation of new drugs and immunological agents, lifestyle and psychological aspects, and biostatistics and informatics. The book will be an excellent reference for practitioners, interns and residents in medical oncology, oncologic surgery, radiotherapy, pathology, and human genetics, researchers, and advanced medical students.

 Authored by experienced radiologists and surgeons, Imaging in Abdominal Surgery, by Drs. Michael P. Federle and James Lau, is a unique reference specially tailored to meet the needs of today's general surgeons. This one-stop resource provides high-quality visual information to help guide clinical diagnosis, surgical planning, and postoperative evaluation. Ideal for surgeons at all levels of expertise, it contains pertinent cross-sectional imaging anatomy as well as the principles underlying the optimal selection of imaging modalities and protocols.

Provides thorough coverage of abdominal radiology especially relevant to general surgeons, including important diagnoses, radiology background and terminology, normal imaging anatomy, and easy-to-understand captions with just the right amount of detail

Covers key topics such as imaging evaluation of blunt and penetrating trauma, imaging evaluation of the "acute abdomen," and optimal pre- and postoperative evaluation for esophageal cancer, bariatric, and antireflux surgery

Features a consistent, bulleted format highlighted by abundant multi-modality images of the adult GI tract, all designed for quick reference at the point of care

Details how to choose among different imaging tests in evaluating specific clinical situations, including the strengths and weaknesses of those tests

Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Scott-Brown's Otorhinolaryngology is used the world over as the definitive reference for trainee ENT surgeons, audiologists and trainee head and neck surgeons, as well as specialists who need detailed, reliable and authoritative information on all aspects of ear, nose and throat disease and treatment. Key points: ? accompanied by a fully searchable electronic edition, making it more accessible, containing the same content as the print edition, with operative videos and references linked to Medline ? highly illustrated in colour throughout to aid understanding ? updated by an international team of editors and contributors ? evidence-based guidelines will help you in your clinical practice ? features include key points, best clinical practice guidelines, details of the search strategies used to prepare the material and suggestions for future research ? new Endocrine section. Scott-Brown will provide trainee surgeons (ENT and Head and Neck), audiologists and ENT physicians with quick access to relevant information about clinical conditions, and provide them with a starting point for further research. The accompanying electronic edition, enhanced with operative videos, will enable both easy reference and accessibility on the move.

This second edition of Pediatric Diagnosis is a colour atlas of clinical conditions in pediatric surgery. It provides an illustrated guide to the diagnosis of all common and most rare paediatric surgical conditions. Extensively used for examination preparation, the atlas comprises 1400 photographs of congenital and acquired anomalies. This book offers extensive coverage of all the common, and many of the rare conditions in paediatric surgery. Table of Contents Antenatal diagnosis. Major neonatal conditions. Head and neck. The thorax. The abdomen. Abdominal wall and inguino-scrotal conditions. The Urinary tract. Gynaecological conditions. The limbs and soft tissues.

Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome, Second Edition, provides an overview of the current diabetes epidemic, outlines the consequences of this crisis, and lays out strategies to forestall and prevent diabetes, obesity and other intricate issues of metabolic syndrome. Contributing experts provide up-to-date global approaches to the critical consequences of metabolic syndrome and make the book an important reference for those working with the treatment, evaluation or public health planning for the effects of metabolic syndrome and diabetes. Completely revised with 15 new chapters, the book includes coverage of the roles of gut microbiome in obesity and diabetes, macrovascular and microvascular complications, diabetes, metabolic syndrome and kidney disease, aspects of diabetic cardiomyopathy, diabetes, Alzheimer?s and neurodegenerative diseases, roles of SGLT2 inhibitors in the treatment of type 2 diabetes, novel biomarkers in diabetes, roles of Trigonella foenum-graecumseed extract in type 2 diabetes, beneficial effects of chromium (III) and vanadium supplements in diabetes, prevention of type 1 diabetes, novel drugs in the therapeutic intervention of type 2 diabetes, eHealth and mobile apps for self-management, artificial pancreatic transplantation, non-invasive glucose monitoring, and the app for glucose regulation. Contains a scientific discussion of the epidemiology and pathophysiology of the relationship between diabetes and metabolic syndrome Includes coverage of Pre-diabetes conditions, plus both Type I and Type II Diabetes Presents both prevention and treatment options

Covering the full spectrum of endoscopic ultrasound, Endosonography, 4th Edition, by Drs. Robert Hawes, Paul Fockens, and Shyam Varadarajulu, is a comprehensive, one-stop resource for mastering both diagnostic and therapeutic EUS procedures. Leading global authorities guide you step by step through both introductory and advanced techniques, covering everything from interpretation and accurate diagnosis to treatment recommendations. Dozens of how-to videos, high-quality images, and an easy-to-navigate format make this updated reference a must-have for both beginning and experienced endosonographers.

Features:

•             Provides practical information on establishing an endoscopic practice, from what equipment to buy to providing effective cytopathology services.

•             Employs a user-friendly templated format to cover all topics from basic applications to advanced interventions, with procedures organized by body system.

New To This Edition:

•             Features completed updated content throughout, including new sections on high-intensity focused ultrasound, through-the-needle biopsy, benign pancreatic masses, and gastro-jejunostomy.

•             Includes perspectives from new contributors who provide global experience and knowledge.

•             Contains new and enhanced illustrations that correlate with high-quality endoscopic images.

•             Teaches clinically relevant techniques through dozens of new how-to videos.

•             Covers cutting-edge techniques for performing therapeutic interventions, such as drainage of pancreatic pseudocysts and EUS-guided anti-tumor therapy, as well as fine needle aspiration (FNA) procedures.

•             Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

 Seven Bypasses: Tenets and Techniques for Revascularization is the third book in a trilogy of bravura, technical nuance, and strategy by master neurosurgeon Michael Lawton. Like his first two books on aneurysms and AVMs, Seven Bypasses provides unparalleled firsthand insights and guidance on complex pathologies in vascular neurosurgery. The fundamentals of microsurgical anastomosis and the craft of bypass surgery are explored in depth with clinical pearls in every chapter.

Lawton eloquently reveals the art of cerebral revascularization in exquisite, metaphorical detail. The surgeon performing bypass surgery is like an architect envisioning and building a beautiful structure. A bypass is designed to fit the patient's unique anatomy; blueprints designate anastomotic sites, connections, and conduits; the anastomoses are constructed; and the bypass is brought to life with pulsations, flow, and reperfusion. The book highlights Lawton's aesthetic, which has evolved from the common STA-MCA bypasses to IC-IC bypasses and elaborate arterial reconstructions.

Key Highlights

•         Stepwise discussion of the three anastomoses that form the building blocks of all bypasses: end-to-side, side-to-side, and end-to-end anastomoses

•         Ten tenets delineate nuances of bypass: dexterity, preparing donors and recipients, establishing a working zone, temporary arterial occlusion, arteriotomy, suturing technique, tissue handling, knot tying, patency, and aneurysm occlusion

•         Step-by-step guidance on the seven bypasses: EC-IC bypass, EC-IC interpositional bypass, arterial reimplantation, in-situ bypass, reanastomosis, IC-IC interpositional bypass, and combination bypass

•         Strategies and algorithms for aneurysms organized by specific anatomical sites, including the MCA and the Sylvian cistern, ACA and the interhemispheric cistern, basilar artery and the basal cisterns, and PICA and the cisterna magna

•         More than 1,500 radiographs, operative photographs, and exquisite illustrations drawn by artist Kenneth Xavier Probst elucidate anatomy, surgical principles, and clinical cases

Dr. Lawton has bequeathed a remarkable treasure of knowledge to current and future generations of neurosurgeons and their patients. The Seven series is destined to be an enduring classic for residents, fellows, and neurosurgeons specializing in the treatment of cerebrovascular disease, and for those who believe that manual dexterity and technical skill still matter.

As part of the successful THE REQUISITES series, the second edition of Thoracic Radiology: The Requisites, by Theresa McLoud, MD and Phillip Boiselle, MD, presents the most essential information you need to know about chest radiology, including some of the more recent techniques in chest imaging such as CTA and PET imaging. Its concise and up-to-date coverage prepares you for examinations and clinical practice. Abundantly illustrated with over 800 images and covering all functional units of chest organs, this book discusses diagnostic imaging of the most frequently seen problems and the interventional techniques performed in thoracic radiology.

Summarizes key information with numerous outlines, tables, ''pearls,'' and boxed material for easy reference.

Focuses on essentials to pass the certifying board exam and ensure accurate diagnoses in clinical practice.

Approximately 90% of the more than 1,000 images are new, reflecting the very latest thoracic imaging modalities and techniques. Many diagrams and images are also now in full color.

New material on acute and critical care including post-operative complications, trauma, ICU diagnosis, and implantable devices.

More interventional content including diagnostic biopsy techniques, fiducial placement to aid VATs resection, and ablative therapies including microwave and cryoablation.

Expanded and updated lung cancer coverage including new tumor staging, new surgical and bronchoscopic staging techniques, and lung cancer screening.

New information on thoracic MRI indications, protocols, and case material outlining how MRI adds specificity to tissue characterization of masses and extent of disease.

Expanded content on interstitial lung disease including color anatomic drawings and extensive new case material.

Current pulmonary nodule management strategies including the updated 2017 Fleischner criteria for incidental nodules.

New editor, authors, and section editors bring a fresh perspective to this completely revised book.

Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of electronic devices.

Widely known as THE survival guide for radiology residents, fellows, and junior faculty, the "purple book" provides comprehensive, up-to-date coverage of diagnostic imaging in an easy-to-read, bulleted format. Focusing on the core information you need for learning and practice, this portable resource combines the full range of diagnostic imaging applications with the latest imaging modalities, making it the perfect clinical companion and review tool. Table Of Contents: Primer of Diagnostic Imaging 6th Edition 1. Chest Imaging 2. Cardiac Imaging 3. Gastrointestinal Imaging 4. Genitourinary Imaging 5. Musculoskeletal Imaging 6. Neurologic Imaging 7. Head and Neck Imaging 8. Vascular Imaging 9. Breast Imaging 10. Obstetric Imaging 11. Pediatric Imaging 12. Nuclear Imaging 13. Contrast Agents 14. Imaging Physics

Ronald E. Goldstein?s Esthetics in Dentistry, Third Edition provides a thoroughly updated and expanded revision to the definitive reference to all aspects of esthetic and cosmetic dentistry, from principles and treatments to specific challenges and complications. ? Provides a current, comprehensive examination of all aspects of esthetic and cosmetic dentistry ? Presents 23 new chapters from international experts in the field and complete updates to existing chapters ? Offers more than 3,700 high-quality photographs and illustrations ? Adds clinical case studies and treatment algorithms for increased clinical relevance ? Emphasizes clinical relevance, with all information thoroughly rooted in the scientific evidence

This classic text on paediatric neurology is now in its 4th edition. Leading academics from around the world present evidence from their various areas of expertise, placing it firmly in the clinical context. Each chapter covers the basic science of the disorder and relevant genetic advances. New to this edition are chapters on fetal neurology, movement disorders, basal ganglia disease and psychogenic disorders. References at the end of each chapter are thorough, guiding the clinician to relevant further reading. The international team of editors has maintained the clinical approach of the late Jean Aicardi, which distinguishes this book from others in the field. Succinctly given, patient-focused information makes Aicardi's Diseases of Nervous System in Childhood a comprehensive yet readable resource for busy clinicians in paediatric neurology, general paediatrics, neurodisability and all the related medical disciplines. New for the 4th Edition NEW Completely revised and updated NEW International team of expert editors NEW Updates on genetic advances NEW Sections on Fetal Neurology, Basal Ganglia and Movement Disorders NEW Easy to use presentation NEW Full colour illustrations throughou

Following the success of the previous three editions, Physical Management for Neurological Conditions 4th edition remains the most up-to-date evidence-based textbook for undergraduate students and qualified health professionals. Written by an international team of clinicians and researchers, it is applicable to a number of healthcare systems, with a special focus on physiotherapy. New chapters have been added to cover both common and rare conditions, such as hereditary disorders, functional motor disorders, and neuromuscular diseases. Together with the Pocketbook of Neurological Physiotherapy, it covers all essential components and conditions. Features: ? Comprehensive and handy reference on physical management and movement limitations, suitable to any health care context and environment ? Use of eclectic approach which focuses on selecting the appropriate evidence-based tools to assess and treat neurological conditions without subscribing to any specific treatment approaches ? International case studies are presented to provide worldwide scientific evidence New To This Edition: ? Fully revised by international contributors with the inclusion of 8 new chapters covering: o Common impairments o Inherited neurological disorders o Complex case management o Virtual reality and interactive gaming technologies

With authoritative coverage of rare and common hemostatic disorders, Consultative Hemostasis and Thrombosis, 4th Edition, keeps you both up to date with all that?s new in this fast-moving field as well as reviewing background and development and citing pertinent classical literature. Broad differential diagnoses are provided, underscoring the editors? position that correct treatment begins with correct diagnosis. This trusted resource by Drs. Craig S. Kitchens, Craig M. Kessler, Barbara A. Konkle, Michael B. Streiff, and David A. Garcia is designed for rapid reference and critical decision making at the point of care. Features: ? Emphasizes real-world problems and solutions, with quick access to concise descriptions of each condition, associated symptoms, laboratory findings, differential diagnosis, and treatment. ? Features a user-friendly design, full-color format, abundant laboratory protocols, and at-a-glance tables and charts throughout. New To This Edition: ? Provides thorough updates on core information on hemostasis and thrombosis, including deep venous thrombosis (DVT), pulmonary embolisms, hypercoagulability, thrombocytopenia, von Willenbrand disease, and more. ? Covers new treatment information on hemophilia A and B. ? Contains new chapters on hereditary hemorrhagic telangiectasia, hemolytic uremic syndrome, and paroxymal nocturnal hemoglobinuria. ? Two new editors, Dr. Michael B. Streiff and Dr. David A. Garcia, offer fresh perspectives and valuable experience. ? Expert Consult? eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Hepatobiliary and Pancreatic Surgery meets the needs of surgeons in higher training and practising consultants for a contemporary and evidence-based account of this sub-specialty that is relevant to their general surgical practice. It is a practical reference source incorporating the most current information on recent developments, management issues and operative procedures. The text is thoroughly referenced and supported by evidence-based recommendations wherever possible, distinguishing between strong evidence to support a conclusion, and evidence suggesting that a recommendation can be reached on the balance of probabilities. For this Sixth Edition the authorship team across the series has been expanded to include additional European and World experts, with an increased emphasis on global practice. Throughout all six volumes the contents have been extensively revised in line with recently published evidence. Detailed supportive key references are provided and are also included within the comprehensive list of references in the accompanying ebook. Links to recommended online videos have been added where appropriate. Features: ? The Companion to Specialist Surgical Practice series provides a current and concise summary of the key topics within the major sub-specialties of general surgery. ? Each volume highlights evidence-based practice both in the text and within the extensive list of references at the end of every chapter. New To This Edition: This edition of Hepatobiliary and Pancreatic Surgery includes new chapters on pancreas, islet and liver transplantation. The text includes new treatment options such as radioembolization, antiangiogenics and ALPPS, the latest guidelines on HCC and colorectal liver metastases management with recent evidence on treatment of biliary tract cancer, pancreatic cystic lesions and complicated acute pancreatitis. Over half of the chapters have been re-written by new authors thus ensuring that this edition is fresh, relevant and incorporates the latest developments and most up-to-date evidence base. Table Of Contents: ? Liver function and failure ? Hepatic, biliary and pancreatic anatomy ? Staging and assessment of hepatobiliary malignancies ? Benign liver lesions ? Primary malignant tumours of the liver ? Colorectal liver metastases ? Non-colorectal hepatic metastases ? Portal hypertension and liver transplantation ? Pancreas and Islet transplantation ? Spleen ? Gallstones ? Benign biliary tract diseases ? Malignant lesions of the biliary tract ? Complicated Acute Pancreatitis ? Chronic pancreatitis ? Pancreatic adenocarcinoma ? Cystic and neuroendocrine tumours of the pancreas ? Hepatobiliary and pancreatic trauma

? Provides an easily understood guide and daily reference for the clinical management of melanoma Written by melanoma specialists and experts within their respective fields Richly illustrated with color photographs, figures and illustrations About this book This text serves as a very useful clinical guide and realistic approach to the clinical management of melanoma. Primary care physicians, specialists from varying areas of medical practice and numerous other healthcare providers will find this text to be quite useful as a standard daily reference and use in the office setting. It provides a clear and concise source of information in order to make real-life, evidence-based decisions for all aspects of management for cutaneous melanoma. This book also provides the latest breakthroughs in melanoma research, ranging from recent discoveries in genomics and epigenetics, to newly identified genes that have been selectively targeted for the development of a personalized approach to treatment. All chapters are written by specialists and true experts within their respective fields, incorporating the latest scientific, clinical and evidence-based medicine for melanoma (and non-melanoma skin cancers). This up-to-date information can be easily applied and translated to the clinical setting for the melanoma patient.

Up to 15% of all strokes occur in hospitalized patients, many of whom are there for surgical procedures or cardiac disorders. Outcomes can be poor, with high mortality - possibly related to co-morbidities and the complexities of hospital care. Risk factors for in-hospital stroke include specific operations and procedures (such as cardiac surgery), previous medical disorders (especially a history of stroke or transient ischemic attack), and certain physiological characteristics (including fever and dehydration). More rapid diagnosis and evaluation for interventional therapies is needed. This major new book examines the causes of treatment-related stroke in most hospital-based situations. Therapeutic approaches ? including interventional therapies and intra-arterial thrombolysis ? are highlighted, including experimental agents and interventions where other treatment possibilities are limited. Increasing the awareness of such interventions is an important factor in reducing delays in the assessment of patients who have strokes while in hospital, thus decreasing morbidity and reducing costs.

Now in its third edition, this essential and detailed guide provides wide-ranging support for those diagnosing, treating and assessing complex types of cerebrovascular diseases, in a high pressure, time-constrained environment. Authored by leading clinicians in the field of neurology, and supported by advanced in brain-mapping technologies, this cutting-edge manual provides physicians, neurologists and emergency practitioners at all levels with a vital commentary on those relatively uncommon types of cerebrovascular disease that can lead to patients suffering a stroke. This new edition offers chapter-by-chapter imaging findings, evaluation and management advice, alongside insights into new topics such as CARASIL, sickle cell disease, radiation-induced cerebrovascular disease and blue rubber bleb syndrome. Updated and thorough, the guide provides a clear presentation on the nature, diagnosis, and treatment of everyday symptoms, through to more specialised cases. Building upon existing experience, practitioners can confidently assess patient needs, and correctly diagnose symptoms first time.

This book approaches the topic of management of acute ischemic stroke in an interdisciplinary manner, explaining how best to utilize the methods currently available for medical, surgical, and endovascular care. After an opening section on basics such as pathophysiology, radiological assessment, and pathology, comprehensive and up-to-date information is provided on each of the available therapies, techniques, and practices. Special attention is paid to recent advances in neurointerventional and neurosurgical procedures, with clear description of important technical details.The book includes plentiful high-quality case illustrations and a wealth of practical information that will prove of value in emergency rooms, angiography suites, operating rooms, and intensive care units. It will aid not only neurologists, neurointerventionists, and neurosurgeons, but also all others who are involved in the management of acute ischemic stroke, from radiologists and emergency physicians to healthcare providers.

This book mainly discusses the current status of stroke transnational research and allows the reader to understand the interplay of common comorbidities in the stroke population such as diabetes and hypertension, and provides insight into stroke targets to promote cell survival, angiogenesis, neurogenesis, and most importantly, functional recovery after stroke. Throughout the world, stroke is still a leading cause of mortality and morbidity; each year approximately 15 million people worldwide suffer from stroke. Stroke is now the leading cause of death and disability in China. Large communities of stroke survivors are eagerly awaiting scientific advances in transnational stroke research that would offer neuroprotective therapeutics for acute stroke management, or rehabilitation and regenerative strategies utilizing novel stem cell-based approaches. While research is ongoing, the Editors have compiled this volume to help the further understanding of the pathophysiology of stroke and to review and identify future potential biomarkers. The book is written for students, researchers and physicians in neurosciences, neurology and neuroradiology.

This book provides detailed practical guidance on the management of acute ischemic stroke in the clinical settings encountered in daily practice. Real-life cases are used to depict a wide range of clinical scenarios and to highlight significant aspects of management of ischemic stroke. In addition, diagnostic and therapeutic protocols are presented and helpful decision-making algorithms are provided that are specific to the different professionals involved in delivery of acute stroke care and to differing types of hospital facility. The coverage is completed by the inclusion of up-to-date scientific background information relevant to diagnosis and therapy. Throughout, the approach adopted is both practical and multidisciplinary. The book will be of value for all practitioners involved in the provision of acute stroke care, and also for medical students.

This second edition provides updated and expanded chapters that critically address the issues or rodent stroke modeling, from choosing the model and outcome measures, designing the experiment, conducting and analyzing it, to reporting it in a scientific publication. Rodent Models of Stroke, Second Edition aims to help its readers understand the limitations and the opportunities of modeling stroke in rodents and enable them to conduct experiments which will not only improve our understanding of the pathophysiology of this devastating disorder but also serve as the basis for developing new highly effective treatments. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory. Authoritative and practical, Rodent Models of Stroke, Second Edition provides authoritative reviews of the most commonly used, well-honed approaches in the field today.

This revised, expanded second edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genomewide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed.Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.

This book provides detailed practical guidance on the management of hemorrhagic stroke in the clinical settings encountered in daily practice. Real-life cases are used to depict a wide range of clinical scenarios and to highlight significant aspects of management of hemorrhagic stroke. In addition, diagnostic and therapeutic protocols are presented and helpful decision-making algorithms are provided that are specific to the different professionals involved in delivery of stroke care and to differing types of hospital facility. The coverage is completed by the inclusion of up-to-date scientific background information relevant to diagnosis and therapy. Throughout, the approach adopted is both practical and multidisciplinary. The book will be of value for all practitioners involved in the provision of stroke care, and also for medical students.

This complete resource captures state-of-the-art strategies and the accelerated pace of discovery that is revolutionizing what is known about ischemic stroke and its treatment. Therapeutics for acute management, secondary prevention, recovery, rehabilitation, asymptomatic cerebral ischemia, and implementation of stroke systems of care are all discussed in this comprehensive yet practical guide. Chapters are authored by leading academicians with extensive clinical practice experience from all over the world and feature the scientific evidence behind prevailing therapeutic strategies for managing ischemic cerebrovascular disease. The specialist or general practitioner will gain critical knowledge in stroke management, current clinical challenges and promising new therapies under investigation.

Part of McGraw-Hill?s Radiology Case Review Series, this unique resource challenges you to look at a group of images, determine the diagnosis, answer related questions, and gauge your knowledge by reviewing the answer. It all adds up to the best review of chest imaging available?one that?s ideal for certification or recertification, or as an incomparable clinical refresher. Distinguished by a cohesive 2-page design, each volume in this series is filled with cases, annotated images, questions & answers, pearls, and relevant literature references that will efficiently prepare you for virtually any exam topic. Radiology and cardiac residents and fellows, medical students, radiologists, and physicians who want to increase their knowledge of chest imaging will find this book to be an invaluable study partner.

This book gives a comprehensive overview on the use of image-guided radiation therapy (IGRT) in the treatment of lung cancer, covering step-by-step guidelines for clinical implementations, fundamental principles and key technical advances. It covers benefits and limitations of techniques as well as quality and safety issues related to IGRT practice. Addresses imaging simulation, treatment planning, verification, and delivery Discusses important quality assurance issues Describes current methods using specialized machines and technologies Jing Cai, PhD, is an Associate Professor of Radiation Oncology at Duke University Medical Center. Joe Y. Chang, MD, PhD, is Professor in the Department of Radiation Oncology at The University of Texas MD Anderson Cancer Center in Houston. Fang-Fang Yin, PhD, is Chief of the Division of Radiation Physics, Professor of Radiation Oncology, and Director of the Medical Physics program at Duke University.

Lung cancer remains the leading cause of cancer-related deaths worldwide. Early diagnosis can improve the effectiveness of treatment and increase a patient?s chances of survival. Thus, there is an urgent need for new technology to diagnose small, malignant lung nodules early as well as large nodules located away from large diameter airways because the current technology?namely, needle biopsy and bronchoscopy?fail to diagnose those cases. However, the analysis of small, indeterminate lung masses is fraught with many technical difficulties. Often patients must be followed for years with serial CT scans in order to establish a diagnosis, but inter-scan variability, slice selection artifacts, differences in degree of inspiration, and scan angles can make comparing serial scans unreliable. Lung Imaging and Computer Aided Diagnosis brings together researchers in pulmonary image analysis to present state-of-the-art image processing techniques for detecting and diagnosing lung cancer at an early stage. The book addresses variables and discrepancies in scans and proposes ways of evaluating small lung masses more consistently to allow for more accurate measurement of growth rates and analysis of shape and appearance of the detected lung nodules. Dealing with all aspects of image analysis of the data, this book examines: Lung segmentation Nodule segmentation Vessels segmentation Airways segmentation Lung registration Detection of lung nodules Diagnosis of detected lung nodules Shape and appearance analysis of lung nodules Contributors also explore the effective use of these methodologies for diagnosis and therapy in clinical applications. Arguably the first book of its kind to address and evaluate image-based diagnostic approaches for the early diagnosis of lung cancer, Lung Imaging and Computer Aided Diagnosis constitutes a valuable resource for biomedical engineers, researchers, and clinicians in lung disease imaging.

Part of the highly regarded Specialty Imaging series, this fully updated second edition by Drs. Santiago Mart�nez-Jim�nez, Melissa L. Rosado-de-Christenson, and Brett W. Carter, reflects the many recent changes in HRCT diagnostic interpretation. An easy-to-read bulleted format and state of the art imaging examples guide you step-by-step through every aspect of thin-section CT and HRCT in the evaluation of patients with suspected lung disease. This book is an ideal resource for radiologists who need an easily accessible tool to help them understand the indications, strengths, and limitations of HRCT in their practice. Superb illustrations with comprehensive captions display both typical and variant findings on HRCT scans Introductory sections are specifically designed to lead the general radiologist to differential diagnoses from specific imaging findings, pathologic patterns, or from the disease/pathology itself Time-saving bulleted format distills essential information for fast and easy comprehension Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, videos, and references from the book on a variety of devices. Updated content includes changes in HRCT interpretation and novel disease processes such as DIPNECH, new classification of idiopathic interstitial pneumonias, airway-centered interstitial fibrosis, light-chain deposition disease, and interstitial pneumonia with autoimmune features (IPAF) Fully revised throughout with new references, images, and histopathologic correlations

Computed Tomography of the Lung: A Pattern Approach aims to enable the reader to recognize and understand the CT signs of lung diseases and diseases with pulmonary involvement as a sound basis for diagnosis. After an introductory chapter, basic anatomy and its relevance to the interpretation of CT appearances is discussed. Advice is then provided on how to approach a CT scan of the lungs, and the different distribution and appearance patterns of disease are described. Subsequent chapters focus on the nature of these patterns, identify which diseases give rise to them, and explain how to differentiate between the diseases. The concluding chapter presents a large number of typical and less typical cases that will help the reader to practice application of the knowledge gained from the earlier chapters. Since the first edition, the book has been adapted and updated, with the inclusion of many new figures and case studies.

Written by two of the world?s most respected specialists in the field, Thoracic Imaging: Pulmonary and Cardiovascular Radiology, Third Edition brings you completely up to date with all you need to know for optimal imaging of the heart and lungs. This comprehensive title provides practical, authoritative guidance for the radiologic assessment and diagnosis of both congenital and acquired cardiovascular and pulmonary diseases. A must-have reference for more than ten years, Thoracic Imaging is your one-stop source for current, accurate coverage of pulmonary infections, diffuse lung diseases, mediastinal masses, coronary artery CT, myocardial disease, pericardial disease, CT of ischemic heart disease, and much more. Key Features: Today?s most comprehensive text-reference in the field, written by pulmonary imaging expert W. Richard Webb, MD and cardiac imaging expert Charles B. Higgins, MD. More than 2700 high-quality images, many in full color, help you visualize key aspects of chest imaging. A new chapter on MR and CT in in Atrial and Ventricular Arrhythmias brings you up to date on the latest imaging techniques. Updated images and content throughout, including expanded coverage of PET/CT. Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like: Complete content with enhanced navigation Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web Cross-linked pages, references, and more for easy navigation Highlighting tool for easier reference of key content throughout the text Ability to take and share notes with friends and colleagues Quick reference tabbing to save your favorite content for future use