Central Nervous System Metastases

Focuses on the topic of brain metastases

Provides a comprehensive guide to brain metastasis pathophysiology and management

Presents new therapeutic strategies, such as surgical techniques, radiation therapy techniques and new systemic treatment approaches, including targeted- and immunotherapy

About this book

This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives.

Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach.

Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.

Table of contents (32 chapters)

Epidemiology of Central Nervous System Metastases

Pages 3-14

Dirven, Linda (et al.)

Pathology of Brain Metastasis

Pages 15-29

Mustafa, Dana A. (et al.)

Molecular Mechanisms in Brain Metastasis

Pages 31-41

Er, Ekrem Emrah (et al.)

Genomic Characterization of Brain Metastases: Implications for Precision Medicine

Pages 43-58

Ippen, Franziska M. (et al.)

Brain Metastases Cell Partners and Tumor Microenvironment

Pages 59-71

García-Gómez, Pedro (et al.)

Liquid Biopsy Diagnosis of CNS Metastases

Pages 73-86

Antunes Ferreira, Mafalda (et al.)

Preclinical Models of Brain Metastases

Pages 87-105

Wu, Alex (et al.)

Clinical Presentation of Brain Metastases

Pages 109-115

Compter, Annette (et al.)

Epilepsy in CNS Metastases

Pages 117-125

Rudà, Roberta (et al.)

Safety, Tolerability, and Use of Steroids

Pages 127-137

Wolpert, Fabian (et al.)

Anticoagulation in Patients with Brain Metastases

Pages 139-143

Marosi, Christine (et al.)

Imaging of Brain Metastases: Diagnosis and Monitoring

Pages 145-158

Garcia, Gabriel C. T. E. (et al.)

Metabolic Imaging of Brain Metastasis

Pages 159-171

Galldiks, Norbert (et al.)

Clinical, Imaging, and CSF Cytological Presentation of Leptomeningeal Metastases from Solid Non-CNS Primary Tumors

Pages 173-179

Le Rhun, Emilie (et al.)

Surgery in Brain Metastasis Management: Therapeutic, Diagnostic, and Strategic Considerations

Pages 183-190

Metellus, Philippe (et al.)

Surgical Resection for Brain Metastases

Pages 191-198

Haider, Ali S. (et al.)

Stereotactic Radiosurgery for Brain Metastases

Pages 199-238

Marques, Christophe (et al.)

Whole Brain Radiotherapy (WBRT) for Brain Metastases

Pages 239-245

Dhermain, Frédéric

Combining Radiosurgery and Systemic Therapies for Treatment of Brain Metastases

Pages 247-258

Chiang, Veronica (et al.)

Brain Metastases from Lung Tumors

Pages 259-266

Dhawan, Andrew (et al.)

Current Treatment Strategies in Breast Cancer Brain Metastases

Pages 267-279

Bartsch, Rupert (et al.)

Management of Melanoma Brain Metastasis

Pages 281-287

Boutros, C. (et al.)

Miscellaneous Metastases

Pages 289-299

Dhawan, Andrew (et al.)

Treatment of Leptomeningeal Metastases

Pages 301-311

Le Rhun, Emilie (et al.)

Neurocognitive Toxicity from Radiation Therapy for Brain Metastases

Pages 315-328

Feghali, Karine A. (et al.)

Neurological Complications of Chemotherapy

Pages 329-340

Diaz, Maria (et al.)

Neurological Complications of Targeted Therapies

Pages 341-363

Chukwueke, Ugonma N. (et al.)

Neurological Complications of Immune-Based Therapies

Pages 365-372

Chukwueke, Ugonma N. (et al.)

Health-Related Quality of Life Related to Toxicity Treatments in Central Nervous System Metastases

Pages 373-382

Walbert, Tobias (et al.)

Prognostic Indices for Patients with Brain Metastases

Pages 385-396

Sperduto, Paul W.

Prevention Strategies for Brain Metastasis

Pages 397-406

Soffietti, Riccardo (et al.)

Clinical Trials: Endpoints and Outcome Assessment

Pages 407-421

Lin, Nancy U.