Age-Related Macular Degeneration

Book Description:

The value of Age-Related Macular Degeneration has stood the test of time, but progress in both basic and clinical ophthalmology has been relentless, mandating the need for an updated book. This second edition focuses on the pathophysiology and the epidemiology of age-related macular degeneration (AMD), the clinical features and management of dry and wet AMD, imaging techniques, and medical therapy for both non-neovascular AMD and neovascular AMD. It describes both clinically validated and experimental therapies as well as rehabilitation technology, and presents strategies to prevent the progression of non-exudative AMD. Results from current clinical trials are also included.

New chapters in this edition cover:

Genetics and treatment

Oxidative stress and its relation to the pathophysiology of AMD and CNV (choroidal neovascularization—a common symptom of wet AMD)

Polypoidal choroidal vasculopathy

Microperimetry and psychophysical testing and ways to track geographic atrophy progression

Non-VEGF pathways

Retinal stem cells

Table of Contents:

1. Histopathology of age-related macular degeneration

2. Immunology of age-related macular degeneration

3. Genetics of age-related macular degeneration

4. Choroidal neovascularization: VEGF pathways

5. Risk factors for age-related macular degeneration and choroidal neovascularization

6. Oxidative stress

7. Geographic atrophy

8. Non-neovascular age-related macular degeneration

9. Neovascular age-related macular degeneration

10. Polypoidal choroidal vasculopathy

11. Variants of neovascular age-related macular degeneration: Type 3 neovascularization (intraretina

12. Role of fluorescein angiography in the treatment of age-related macular degeneration

13. Use of indocyanine green angiography in the management of age-related macular degeneration

14. Role of optical coherence tomography in the evaluation of age-related macular degeneration

15. How to analyze OCT images for management of neovascular age-related macular degeneration

16. Fundus autofl uorescence imaging in age-related macular degeneration

17. Microperimetry and psychophysical testing to aid in the determination of progression of age-rela

18. Laser photocoagulation for choroidal neovascularization

19. Anti-VEGF drugs and clinical trials

20. Non-VEGF related antiangiogenesis pathways for treatment of age-related macular degeneration

21. Radiation therapy for age-related macular degeneration

22. Combination therapy for age-related macular degeneration

23. Photodynamic therapy for neovascular age-related macular degeneration

24. Photocoagulation of AMD-associated CNV feeder vessels: An optimized approach

25. Macular translocation and other surgical treatments

26. Prophylactic treatment: The AREDS study results

27. Visual cycle modulation

28. Cellular transplantation for advanced age-related macular degeneration

29. Novel therapeutic interventions: Stem cells

30. Clinical considerations for visual rehabilitation

31. Visual prosthesis for age-related macular degeneration: A challenging and important application

32. Clinical research trials