Williams Hematology, 10th Edition

Description:

The landmark text that has guided generations of hematologists and related practitioners―updated with the latest research findings and improved format and presentation Long revered for its comprehensiveness and extraordinary depth of detail, Williams Hematology provides essential coverage of the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood and marrow cells and coagulation proteins. The text contains a wealth of basic science and translational pathophysiology for optimal, lifelong learning. Experts in research and clinical hematology, the editors are known worldwide for their contributions to the field. This new edition contains everything that has made Williams Hematology the go-to resource for decades and has been updated with new chapters and critical new research into the molecular mechanisms responsible for hematological disorders and the impact on diagnosis and treatment. And the new format enables you to access each chapter via content modules covering key topics, with summaries, infographics, and cases―all linked to review questions for self-assessment. The full-color presentation integrates images of blood and tissue findings where they are cited in the text. NEW TO THIS EDITION: Updated and revised content reflecting the latest research and developments Convenient format that streamlines the learning process and improves retention Additional chapters added on: Immune Checkpoint Inhibitors Immune Cell Therapy: Chimeric Antigen Receptor T Cell Therapy Immune Cell Therapy Dendritic Cell and Natural Killer Cell Therapy The processes of cell death and survival Application of Big Data and Deep Learning in Hematology Williams Hematology Cases with multiple-choice questions including detailed explanations—perfect preparation for the boards Continuously updated online content with comprehensive drug therapy database and other resources

Table of contents:

PART I Clinical Evaluation of the Patient

1. Initial Approach to the Patient: History and Physical Examination

2. Examination of Blood and Marrow Cells

3. Consultative Hematology

PART II The Organization of the Lymphohematopoietic Tissues

4. Structure of the Marrow and the Hematopoietic Microenvironment

5. The Organization and Structure of Lymphoid Tissues

PART III Epochal Hematology

6. Hematology of the Fetus and Newborn

7. Hematology During Pregnancy

8. Hematology in Older Persons

PART IV Molecular and Cellular Hematology

9. Genetic Principles and Molecular Biology

10. Genomics and Epigenomics

11. Cytogenetic and Genetic Abnormalities

12. Application of Big Data and Deep Learning in Hematology

13. Metabolism of Hematologic Neoplastic Cells

14. Cell Death

15. Cell-Cycle Regulation and Hematologic Disorders

16. Signal Transduction Pathways

17. Hematopoietic Stem Cells, Progenitors, and Cytokines

18. The Inflammatory Response

19. Innate Immunity

20. The Biology of Innate Lymphoid Cells and Natural Killer Cells

21. Dendritic Cells and Adaptive Immunity

PART V Therapeutic Principles

22. Immune Checkpoint Inhibitors

23. Immune Cell Therapy: Chimeric Antigen Receptor T-Cell Therapy

24. Immune Cell Therapy: Dendritic Cell and Natural Killer Cell Therapy

25. Vaccine Therapy

26. Gene Therapy for Hematologic Diseases

27. Regenerative Medicine: Induced Pluripotent Stem Cells and Blood Cell Engineering

28. Pharmacology and Toxicity of Antineoplastic Drugs

29. Hematopoietic Stem Cell Transplantation

30. Therapeutic Apheresis: Indications, Efficacy, and Complications

31. Treatment of Infections in the Immunocompromised Host

32. Antithrombotic Therapy

PART VI The Erythrocyte

33. Structure and Composition of the Erythrocyte

34. Erythropoiesis and Red Cell Turnover

35. Clinical Manifestations and Classification of Erythrocyte Disorders

36. Aplastic Anemia: Acquired and Inherited

37. Pure Red Cell Aplasia

38. Anemia of Chronic Disease

39. Erythropoietic Effects of Endocrine Disorders

40. The Hereditary Dyserythropoietic Anemias

41. Paroxysmal Nocturnal Hemoglobinuria

42. Folate, Cobalamin, and Megaloblastic Anemias

43. Iron Metabolism

44. Iron Deficiency and Overload

45. Anemia Resulting from Other Nutritional Deficiencies

46. Anemia Associated with Marrow Infiltration

47. Erythrocyte Membrane Disorders

48. Erythrocyte Enzyme Disorders

49. Thalassemia: A Disorder of Globin Synthesis

50. Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities

51. Methemoglobinemia and Other Dyshemoglobinemias

52. Fragmentation Hemolytic Anemia

53. Erythrocyte Disorders as a Result of Toxic Agents

54. Hemolytic Anemia Resulting from Infections with Microorganisms

55. Hemolytic Anemia Resulting from Immune Injury

56. Alloimmune Hemolytic Disease of the Fetus and Newborn

57. Hypersplenism and Hyposplenism

58. Primary and Secondary Erythrocytoses/Polycythemias

59. The Porphyrias

60. Polyclonal and Hereditary Sideroblastic Anemias

PART VII Neutrophils, Eosinophils, Basophils, and Mast Cells

61. Structure and Composition of Neutrophils, Eosinophils, and Basophils

62. Classification and Clinical Manifestations of Neutrophil Disorders

63. Neutropenia and Neutrophilia

64. Disorders of Neutrophil Function

65. Eosinophils and Their Disorders

66. Basophils and Mast Cells and Their Disorders

PART VIII Monocytes and Macrophages

67. Structure, Receptors, and Functions of Monocytes and Macrophages

68. Production, Distribution, and Activation of Monocytes and Macrophages

69. Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages

70. Monocytosis and Monocytopenia

71. Inflammatory and Malignant Histiocytosis

72. Gaucher Disease and Related Lysosomal Storage Diseases

PART IX Lymphocytes and Plasma Cells

73. The Structure of Lymphocytes and Plasma Cells

74. Lymphopoiesis

75. Functions of B Lymphocytes and Plasma Cells In Immunoglobulin Production

76. Functions of T Lymphocytes: T-Cell Receptors for Antigen

77. Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders

78. Lymphocytosis and Lymphocytopenia

79. Immunodeficiency Diseases

80. Hematologic Manifestations of Human Immunodeficiency Virus and the Acquired Immunodeficiency Syndrome

81. Mononucleosis Syndromes

PART X Malignant Myeloid Diseases

82. Classification and Clinical Manifestations of the Clonal Myeloid Disorders

83. Polycythemia Vera

84. Essential Thrombocythemia

85. Primary Myelofibrosis

86. Myelodysplastic Syndromes

87. Acute Myelogenous Leukemia

88. Chronic Myelogenous Leukemia and Related Disorders

PART XI Malignant Lymphoid Diseases

89. Classification of Malignant Lymphoid Disorders

90. Acute Lymphoblastic Leukemia

91. Chronic Lymphocytic Leukemia

92. Hairy Cell Leukemia

93. Large Granular Lymphocytic Leukemia

94. General Considerations of Lymphomas: Incidence Rates, Etiology, Diagnosis, Staging, and Primary Extranodal Disease

95. Pathology of Lymphomas

96. Hodgkin Lymphoma

97. Diffuse Large B-Cell Lymphoma and Related Diseases

98. Follicular Lymphoma

99. Mantle Cell Lymphoma

100. Marginal Zone B-Cell Lymphomas

101. Burkitt Lymphoma

102. Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sézary Syndrome)

103. Mature T-Cell and Natural Killer Cell Lymphomas

104. Plasma Cell Neoplasms: General Considerations

105. Essential Monoclonal Gammopathy

106. Myeloma

107. Immunoglobulin Light Chain Amyloidosis

108. Macroglobulinemia

109. Heavy-Chain Disease

PART XII Hemostasis and Thrombosis

110. Megakaryopoiesis and Thrombopoiesis

111. Platelet Morphology, Biochemistry, and Function

112. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis

113. Control of Coagulation Reactions

114. Vascular Function in Hemostasis

115. Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis

116. Thrombocytopenia

117. Heparin-Induced Thrombocytopenia

118. Hereditary and Reactive Thrombocytosis

119. Inherited Platelet Disorders

120. Acquired Qualitative Platelet Disorders

121. The Vascular Purpuras

122. Hemophilia A and Hemophilia B

123. Inherited Deficiencies of Coagulation Factors II, V, V+VIII, VII, X, XI, and XIII

124. Hereditary Fibrinogen Abnormalities

125. von Willebrand Disease

126. Antibody-Mediated Coagulation Factor Deficiencies

127. Disseminated Intravascular Coagulation

128. Thrombotic Microangiopathies

129. Hemolytic Uremic Syndrome

130. Hemostatic Alterations in Liver Diseases and Liver Transplantation

131. Hereditary Thrombophilia

132. The Antiphospholipid Syndrome

133. Venous Thrombosis

134. Atherothrombosis: Disease Initiation, Progression, and Treatment

135. Fibrinolysis and Thrombolysis

PART XIII Transfusion Medicine

136. Erythrocyte Antigens and Antibodies

137. Human Leukocyte and Platelet Antigens

138. Blood Procurement and Red Cell Transfusion

139. Preservation and Clinical Use of Platelets

140. Using Plasma and Plasma Component Therapy

Acronyms and Abbreviations

Index