Volpe’s Neurology of the Newborn, 7th Edition

 

Description: Stay up to date with today’s latest advances in diagnosis and management, as well as the many scientific and technological advances that are revolutionizing neonatal neurology, with the definitive text in the field. Volpe's Neurology of the Newborn, 7th Edition, shares the knowledge and expertise of world authority Dr. Joseph Volpe, who, along with Dr. Terrie E. Inder of Children’s Hospital of Orange County and other distinguished editors, brings a wealth of insight to this classic text. Known for its clear, engaging writing style, vibrant, full-color illustrations, and authoritative information throughout, this reference is an indispensable resource for those who provide care for neonates with neurological conditions.

Features:

Provides clear, comprehensive coverage of neonatal neurology in Dr. Joseph Volpe’s own legendary, readable manner—for a masterful, cohesive source of answers to any question that arises in your practice. Brings the latest science into the clinical setting, with an emphasis on translating new knowledge to the infant’s bedside. Offers comprehensive updates with summary tables and text to reflect major advances in the study of hemorrhage; new insights into molecular genetics and molecular characterization of brain tumors; significant advances in drugs and the developing nervous system; and much more. Includes new chapters on fetal neurology which address the importance of understanding and investigating the maternal-fetal origins of neonatal disease, as well as new chapters on neurodevelopmental follow-up, inflammation, and neurology in low-resource settings. Contains more than 1,000 illustrations: clinical and pathological specimens, key experimental findings, schematics, algorithms, anatomical drawings, and neuroimaging throughout, as well as numerous tables and boxes that synthesize key points. An digital version is included with purchase. The digital allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

 

 

Table of Contents:

 

Unit I: Human Brain Development

Chapter 1. Neural Tube Development

Introduction

NORMAL DEVELOPMENT OF THE FUNDAMENTAL CENTRAL NEURO-AXIS

DISORDERS OF CRANIOSPINAL DEVELOPMENT

KEY REFERENCES

References

Chapter 2. Prosencephalic Development

Normal Prosencephalic Development

Disorders of Prosencephalic Development

KEY REFERENCES

REFERENCES

Chapter 3. Ventricular Development, Ventriculomegaly, and Hydrocephalus in the Fetus and Newborn

Introduction

Fetal Ventriculomegaly

Fetal Ventriculomegaly and Hydrocephalus

Management of Fetal Ventriculomegaly and Congenital Hydrocephalus

Prognosis of Fetal Ventriculomegaly and Congenital Hydrocephalus

KEY REFERENCES

REFERENCES

Chapter 4. Normal and Abnormal Development of the Posterior Fossa Structures

NORMAL DEVELOPMENT OF THE BRAINSTEM AND CEREBELLUM

ABNORMAL DEVELOPMENT OF THE POSTERIOR FOSSA STRUCTURES

KEY REFERENCES

REFERENCES

Chapter 5. Neuronal Proliferation

NEURONAL PROLIFERATION

Key References

References

Chapter 6. Neuronal Migration

MIGRATION

KEY REFERENCES

REFERENCES

Chapter 7. Organizational Events

NORMAL DEVELOPMENT

DISORDERS OF ORGANIZATIONAL EVENTS

DISORDERS OF MULTIPLE ORGANIZATIONAL EVENTS DELINEATED IN VIVO RELATED TO PREMATURITY-ASSOCIATED FACTORS

Conclusions

KEY REFERENCES

References

Chapter 8. Myelination Events

NORMAL DEVELOPMENT

DISORDERS

KEY REFERENCES

REFERENCES

Unit II: Fetal Neurology

Chapter 9. Specialized Diagnostic Studies for Assessment of the Fetal Central Nervous System

INTRODUCTION

IMAGING THE FETAL BRAIN

GENETIC EVALUATION OF FETAL BRAIN ANOMALIES

Conclusions

KEY REFERENCES

REFERENCES

Chapter 10. Placental Conditions With Consequences for the Fetal Brain

DEVELOPMENT OF NORMAL PLACENTAL STRUCTURE AND FUNCTION

ABNORMAL PLACENTAL DEVELOPMENT

KEY REFERENCES

REFERENCES

Chapter 11. Maternal and Fetal Conditions With Consequences for the Fetal Brain

ENDOCRINE DISORDERS IN PREGNANCY AND THE DEVELOPING FETAL BRAIN

MATERNAL MENTAL HEALTH DISORDERS OF PREGNANCY, FETAL BRAIN DEVELOPMENT, AND LONG-TERM NEUROPSYCHOLOGIC OUTCOME

FETAL CONDITIONS WITH SECONDARY ADVERSE EFFECTS ON THE FETAL BRAIN: CONGENITAL HEART DISEASE AND FETAL BRAIN DEVELOPMENT

KEY REFERENCES

REFERENCES

Unit III: Neurological Evaluation

Chapter 12. Neurological Examination: Normal and Abnormal Features

INTRODUCTION

NORMAL NEUROLOGICAL EXAMINATION

ABNORMAL NEUROLOGICAL FEATURES

VALUE OF THE NEONATAL NEUROLOGICAL EXAMINATION

KEY REFERENCES

REFERENCES

Chapter 13. Specialized Neurological Studies

CEREBROSPINAL FLUID EXAMINATION

NEUROPHYSIOLOGICAL STUDIES

Acknowledgement

KEY REFERENCES

REFERENCES

Chapter 14. Neurodevelopmental Follow-Up of High-Risk Newborns

INTRODUCTION

PRIMARY PURPOSE OF NEURODEVELOPMENTAL FOLLOW-UP

NEURODEVELOPMENT

WHICH INFANTS NEED FOLLOW-UP

MODELS OF NEURODEVELOPMENTAL FOLLOW-UP

TIMING OF FOLLOW-UP ASSESSMENTS

NEURODEVELOPMENTAL FOLLOW-UP PROGRAMS

FUNCTIONAL NEURODEVELOPMENTAL DOMAINS

CONCLUSIONS

Acknowledgment

KEY REFERENCES

REFERENCES

Unit IV: Seizures

Chapter 15. Neonatal Seizures

INTRODUCTION

PATHOPHYSIOLOGY

CLASSIFICATION

ETIOLOGY

DIAGNOSIS

PROGNOSIS

MANAGEMENT

KEY REFERENCES

REFERENCES

Unit V: Hypoxic-Ischemic and Related Disorders

Chapter 16. Pathophysiology: General Principles

DEFINITIONS

CAUSES OF PATHOLOGICAL HYPOXIA-ISCHEMIA

THE EVOLUTION OF CEREBRAL INJURY

PRIMARY MEDIATORS OF HYPOXIC-ISCHEMIC INJURY IN THE NEWBORN BRAIN—PHYSIOLOGICAL AND BIOCHEMICAL

CONCLUSIONS

KEY REFERENCES

REFERENCES

Chapter 17. Inflammation and the Newborn Brain

INTRODUCTION

EPIDEMIOLOGICAL AND CLINICAL EVIDENCE OF THE INPUT OF INFLAMMATION AND NEUROINFLAMMATION IN TERM NEWBORNS

EPIDEMIOLOGICAL AND CLINICAL EVIDENCE OF THE IMPACT OF INFLAMMATION AND NEUROINFLAMMATION IN PRETERM NEWBORNS

IMMUNE MEDIATORS

NEUROINFLAMMATION IN NEONATAL ENCEPHALOPATHY: EXPERIMENTAL STUDIES IN HYPOXIC-ISCHEMIC MODELS

SYSTEMIC INFLAMMATION, NEUROINFLAMMATION, AND BILATERAL COMMUNICATION IN PRETERM NEWBORNS

IMPACT OF NEUROINFLAMMATION ON THE PRETERM BRAIN

THE TERTIARY PHASE OF NEUROINFLAMMATION IN PRETERM INFANTS

IMPLICATIONS FOR NEUROPROTECTIVE STRATEGIES IN NEWBORNS

KEY REFERENCES

REFERENCES

Chapter 18. Encephalopathy of Prematurity: Neuropathology

NEUROPATHOLOGICAL FEATURES OF THE ENCEPHALOPATHY OF PREMATURITY

ENCEPHALOPATHY OF PREMATURITY—NEUROPATHOLOGY IN LIVING INFANTS

KEY REFERENCES

REFERENCES

Chapter 19. Encephalopathy of Prematurity: Pathophysiology

OVERVIEW OF PATHOGENESIS

PRETERM CEREBRAL GRAY MATTER INJURY AND DYSMATURATION

KEY REFERENCES

REFERENCES

Chapter 20. Encephalopathy of the Preterm—Clinical Aspects

INTRODUCTION

CLINICAL SETTINGS

NEUROLOGIC SYNDROME

DIAGNOSIS

PROGNOSIS AND CLINICOPATHOLOGICAL CORRELATIONS

MANAGEMENT

CONCLUSION

Acknowledgement

KEY REFERENCES

REFERENCES

Chapter 21. Intrauterine and Intrapartum Assessment of the Fetus

ANTEPARTUM ASSESSMENT

INTRAPARTUM ASSESSMENT

KEY REFERENCES

References

Chapter 22. Hypoxic-Ischemic Encephalopathy in the Term Infant: Neuropathology

Neuropathology

KEY REFERENCES

References

Chapter 23. Hypoxic-Ischemic Injury in the Term Infant: Pathophysiology

Introduction

PART A

PART B

KEY REFERENCES

References

Chapter 24. Hypoxic-Ischemic Injury in the Term Infant: Clinical-Neurological Features, Diagnosis, Imaging, Management, and Prognosis

CLINICAL SETTINGS

NEUROLOGICAL SYNDROME

Diagnosis

COMPUTED TOMOGRAPHY

MAGNETIC RESONANCE IMAGING

CLINICOPATHOLOGICAL CORRELATIONS

Management

Prognosis

KEY REFERENCES

References

Chapter 25. Stroke in the Newborn

CLASSIFICATION—NOMENCLATURE

PERINATAL ARTERIAL ISCHEMIC STROKE

CEREBRAL SINOVENOUS THROMBOSIS

KEY REFERENCES

References

Unit VI: Intracranial Hemorrhage

Chapter 26. Intracranial Hemorrhage: Subdural, Subarachnoid, Subpial, Intraventricular (Term Infant), Miscellaneous

Overview

SUBDURAL HEMORRHAGE

PRIMARY SUBARACHNOID HEMORRHAGE

INTRAVENTRICULAR HEMORRHAGE OF THE TERM INFANT

SUBPIAL HEMORRHAGE

MISCELLANEOUS EXAMPLES OF NEONATAL INTRACRANIAL HEMORRHAGE

KEY REFERENCES

References

Chapter 27. Cerebellar Hemorrhage

CEREBELLAR HEMORRHAGE: FETUS

CEREBELLAR HEMORRHAGE: PRETERM INFANT

CEREBELLAR HEMORRHAGE: TERM INFANT

KEY REFERENCES

References

Chapter 28. Preterm Intraventricular Hemorrhage/Posthemorrhagic Hydrocephalus

MAGNITUDE OF THE PROBLEM

Neuropathology

Pathogenesis

CLINICAL FEATURES

Diagnosis

Prognosis

Management

Conclusions

KEY REFERENCES

References

Unit VII: Metabolic Encephalopathies

Chapter 29. Glucose

Introduction

Definition

NORMAL METABOLIC ASPECTS

BIOCHEMICAL ASPECTS OF HYPOGLYCEMIA

Neuropathology

CLINICAL ASPECTS

KEY REFERENCES

References

Chapter 30. Bilirubin and Brain Injury

NORMAL BILIRUBIN STRUCTURE AND METABOLISM

Pathophysiology

Neuropathology

CLINICAL ASPECTS OF ACUTE AND CHRONIC BILIRUBIN ENCEPHALOPATHIES

KEY REFERENCES

References

Chapter 31. Amino Acids

OVERVIEW OF AMINOACIDOPATHIES WITH NEONATAL NEUROLOGICAL MANIFESTATIONS

MAPLE SYRUP URINE DISEASE

NONKETOTIC HYPERGLYCINEMIA

HYPERAMMONEMIA

ACQUIRED DISORDERS WITH NEONATAL HYPERAMNONEMIA

MISCELLANEOUS AMINO ACID DISORDERS

KEY REFERENCES

REFERENCES

Chapter 32. Organic Acids

OVERVIEW OF MAJOR ORGANIC ACID DISORDERS AND NEONATAL METABOLIC ACIDOSIS

DISORDERS OF PROPIONATE AND METHYLMALONATE METABOLISM

DISORDERS OF PYRUVATE AND MITOCHONDRIAL ENERGY METABOLISM

DISORDERS OF BRANCHED-CHAIN KETOACID METABOLISM

DISORDERS OF FATTY ACID OXIDATION

OTHER ORGANIC ACID DISORDERS

KEY REFERENCES

REFERENCES

Unit VIII: Degenerative Disorders

Chapter 33. Degenerative Disorders of the Newborn

MAJOR DISORDERS

DISORDERS PRIMARILY AFFECTING GRAY MATTER

DISORDERS PRIMARILY AFFECTING WHITE MATTER

DISORDERS AFFECTING BOTH GRAY AND WHITE MATTER

KEY REFERENCES

REFERENCES

Unit IX: Neuromuscular Disorders

Chapter 34. Evaluation, Special Studies

MOTOR SYSTEM

EVALUATION OF DISORDERS OF THE MOTOR SYSTEM

KEY REFERENCES

REFERENCES

Chapter 35. Arthrogryposis Multiplex Congenita

CLINICAL FEATURES

PATHOGENESIS

CLINICAL CLASSIFICATION

DIAGNOSIS

MANAGEMENT

KEY REFERENCES

REFERENCES

Chapter 36. Levels Above Lower Motor Neuron to Neuromuscular Junction

LEVELS ABOVE THE LOWER MOTOR NEURON

LEVEL OF THE LOWER MOTOR NEURON

LEVEL OF THE PERIPHERAL NERVE

LEVEL OF THE NEUROMUSCULAR JUNCTION

KEY REFERENCES

REFERENCES

Chapter 37. Muscle Involvement and Restricted Disorders

LEVEL OF THE MUSCLE

RESTRICTED NEUROMUSCULAR DISORDERS

DISTINGUISHING FEATURES OF DISORDERS OF THE MOTOR SYSTEM

KEY REFERENCES

REFERENCES

Unit X: Intracranial Infections

Chapter 38. Viral, Protozoan, and Related Intracranial Infections

DESTRUCTIVE VERSUS TERATOGENIC EFFECTS

TORCH INFECTIONS

OTHER VIRUSES

KEY REFERENCES

References

Chapter 39. Bacterial and Fungal Intracranial Infections

BACTERIAL MENINGITIS

BRAIN ABSCESS

DISSEMINATED FUNGAL INFECTION

TETANUS NEONATORUM

Acknowledgment

KEY REFERENCES

REFERENCES

Unit XI: Perinatal Trauma

Chapter 40. Injuries of Extracranial, Cranial, Intracranial, Spinal Cord, and Peripheral Nervous System Structures

INTRODUCTION

MAJOR VARIETIES OF PERINATAL TRAUMA

INJURY TO EXTRACRANIAL, CRANIAL, AND CENTRAL NERVOUS SYSTEM STRUCTURES

INJURY TO PERIPHERAL NERVOUS SYSTEM STRUCTURES

KEY REFERENCES

REFERENCES

Unit XII: Intracranial Mass Lesions

Chapter 41. Brain Tumors and Vein of Galen Malformations

BRAIN TUMORS

VEIN OF GALEN MALFORMATION

ARACHNOID CYSTS

KEY REFERENCES

References

Unit XIII: Drugs and the Developing Nervous System

Chapter 42. Passive Addiction and Teratogenic Effects

MAJOR FACTORS INVOLVED IN NEUROLOGIC DISTURBANCES ASSOCIATED WITH INTRAUTERINE DRUG EXPOSURE

DEVELOPMENTAL CONSEQUENCES FOR THE INFANT

Alcohol

ANTIEPILEPTIC DRUGS

Stimulants

Opioids

Antidepressants

Sedatives

Anesthetics

Marijuana

DRUG USE AND THE PRETERM INFANT

Conclusions

KEY REFERENCES

References

Unit XIV: Neurology in Low Resource Settings

Chapter 43. Neonatal Neurology in the Low-Resource Setting for the Term and Preterm Newborn

Introduction

HIE/NE IN THE TERM-BORN NEWBORN

PREMATURE INFANTS IN THE LRS—IVH

KEY REFERENCES

References

Index

 

An aparitie	11 apr 2024
Autor	Joseph J. Volpe, Terrie E. Inder
Editura	Elsevier
Format	Hardcover
ISBN	9780443105135
Limba	Engleza
Nr pag	1240