Translational Research in Stroke

Description:

This book mainly discusses the current status of stroke transnational research and allows the reader to understand the interplay of common comorbidities in the stroke population such as diabetes and hypertension, and provides insight into stroke targets to promote cell survival, angiogenesis, neurogenesis, and most importantly, functional recovery after stroke. Throughout the world, stroke is still a leading cause of mortality and morbidity; each year approximately 15 million people worldwide suffer from stroke. Stroke is now the leading cause of death and disability in China. Large communities of stroke survivors are eagerly awaiting scientific advances in transnational stroke research that would offer neuroprotective therapeutics for acute stroke management, or rehabilitation and regenerative strategies utilizing novel stem cell-based approaches. While research is ongoing, the Editors have compiled this volume to help the further understanding of the pathophysiology of stroke and to review and identify future potential biomarkers. The book is written for students, researchers and physicians in neurosciences, neurology and neuroradiology.

Table of Contents:

Part I. Stroke Epidemiology-Diagnosis

1. Stroke Therapy Development Successes: Research Guidelines and Embolic Stroke Models for Monotherapy and Adjuvant Therapy Development

2. Recent Success with Endovascular Stroke Therapy

3. Stroke Epidemiology

4. Pathophysiology of Ischemic Stroke

5. Pathophysiology of Hemorrhagic Stroke

6. Brain Imaging for Stroke

7. Unstable Carotid Artery Plaque Evaluation by Ultrasound

8. Hypertension and Stroke

9. Diabetics and Stroke

Part II. Stroke Mechanisms

10. Mitochondrial Dysfunction in Ischemic Stroke

11. Molecular Mechanisms of Inflammation in Stroke

12. Immunology of Ischemic Stroke: Impact, Mechanisms, and Immunomodulatory Therapies

13. Microglia Function in Stroke

14. Angiogenesis and Neurogenesis After Ischemic Stroke

15. MicroRNA Biomarkers for Stroke

16. Animal Models for Ischemic Stroke

Part III. Stroke Therapy

17. Neuroprotection of Heat Shock Proteins (HSPs) in Brain Ischemia

18. Photobiomodulation for Stroke

19. In Vitro Enzymatic Clot Lysis Using Focused Ultrasound Waves as an Adjunct to Thrombolytic Drug Tenecteplase and in Combination with Microbubbles

20. Gene Therapy for Stroke

21. Stem Cell Therapy in Stroke

22. Neuroprotective Strategies in Hemorrhagic Stroke

23. Improving Stroke Rehabilitation with Vagus Nerve Stimulation

24. Post-stroke Motor Rehabilitation

25. The Role of TMS for Predicting Motor Recovery and Outcomes After Stroke

26. Do We Have a Chance to Translate Bench-top Results to the Clinic Adequately? An Opinion