Sunlight, Vitamin D and Skin Cancer

Description:

The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‑exposure to minimize the risks of developing vitamin D deficiency and skin cancer.

Table of contents:

Part I. Introduction

1. Lessons Learned from Paleolithic Models and Evolution for Human Health: A Snap Shot on Beneficial Effects and Risks of Solar Radiation

Part II. UV-Induced Cutaneous Synthesis of Vitamin D and the Physiologic Consequences (I)

2. Sunlight, UV Radiation, Vitamin D, and Skin Cancer: How Much Sunlight Do We Need?

Part III. Solar Radiation, Vitamin D and Human Health

3. Vitamin D Status and Cancer Incidence, Survival, and Mortality

4. Vitamin D Receptor Polymorphisms and Cancer

5. On the Relationship Between Sun Exposure and All-Cause Mortality

6. Epidemiology of Skin Cancer: Update 2019

Part IV. Epidemiology of Skin Cancer

7. Solar UV Exposure and Mortality from Skin Tumors: An Update

8. Solarium Use and Risk for Malignant Melanoma: Many Open Questions, Not the Time to Close the Debate

9. Molecular Biology of Basal and Squamous Cell Carcinomas

Part V. Photocarcinogenesis of Skin Cancer

10. Human Papillomaviruses and Skin Cancer

11. The Immune System and Pathogenesis of Melanoma and Non-melanoma Skin Cancer

12. Protection from Ultraviolet Damage and Photocarcinogenesis by Vitamin D Compounds

Part VI. The Relevance of the Vitamin D Endocrine System for Skin Cancer

13. The Role of Classical and Novel Forms of Vitamin D in the Pathogenesis and Progression of Nonmelanoma Skin Cancers

14. The Vitamin D Receptor as Tumor Suppressor in Skin

15. Crosstalk Between Vitamin D and p53 Signaling in Cancer: An Update

16. Sunlight, Vitamin D, and Xeroderma Pigmentosum

Part VII. Prevention and Management of Skin Cancer

17. Update: Solar UV Radiation, Vitamin D, and Skin Cancer Surveillance in Organ Transplant Recipients (OTRs)

18. Sunscreens in the United States: Current Status and Future Outlook

19. A Handful of Sunscreen for Whole-Body Application

20. Ultraviolet Exposure Scenarios: Balancing Risks of Erythema and Benefits of Cutaneous Vitamin D Synthesis

Part VIII. UV-Induced Cutaneous Synthesis of Vitamin D and the Physiologic Consequences – II. Promise and Outlook

21. The Paleolithic Nutrition Model in Relation to Ultraviolet Light and Vitamin D

Back Matter