Stereotactic and Functional Neurosurgery

Description:

This text presents a comprehensive and state-of the-art approach to stereotactic and functional neurosurgery. Overarching sections include achieving stereotactic precision, defining trajectories and targets, the biophysics of stereotactic therapies, diseases and targets, and the future of functional neurosurgery.  Each section is designed to be inclusive of all relevant topics, serving as an unbiased resource to new clinicians in this field or established clinicians that are aiming to better understand complementary methods. Importantly, each section and the associated chapters can be used by basic and translational scientists as well as engineers and industry to better understand and deliver innovation to the field. Chapters within each section methodically analyze traditional and recently emerging concepts and techniques; address underlying principles with examples drawn from specific diseases and applications; and cover patient selection, target selection, available stereotactic methods, nuanced surgical methods, and clinical evidence across treatment options. Written by experts in each area, Stereotactic and Functional Neurosurgery is a definitive guide to the latest developments in stereotactic targeting, electrode implantation, surgical treatment of neurological and psychiatric disorders, the renaissance of stereotactic lesions, and the frontier of restorative neurosurgery for a variety of disorders that have no other therapeutic options.

Table of Contents:

Part I. Achieving Stereotactic Precision

1. Traditional and Mini-Frames

2. Stereotactic Robots

3. Intraoperative Magnetic Resonance Imaging and Computed Tomography

4. Frameless Image Guidance in Stereotactic Radiosurgery

Part II. Defining Trajectories and Targets

5. Principles of Safe Stereotactic Trajectories

6. Structural Imaging and Target Visualization

7. Network-Based Imaging and Connectomics

8. Microelectrode Recording in Neurosurgical Patients

9. Local Field Potentials and ECoG

10. Awake Testing to Confirm Target Engagement

11. Cloud-Based Stereotactic and Functional Neurosurgery and Registries

Part III. The Biophysics of Functional Neurosurgical Therapy

12. Responsive Neurostimulation

13. Spinal Stimulation

14. Peripheral Nerve Stimulation

15. Non-invasive Central Neuromodulation with Transcranial Magnetic Stimulation

16. Ablation: Radiofrequency, Laser, and HIFU

17. Radiosurgery

Part IV. The Future of Functional Neurosurgery

18. Parkinson’s Disease: Deep Brain Stimulation

19. Parkinson’s Disease: Lesions

20. Essential Tremor: Deep Brain Stimulation

21. Essential Tremor: Lesions

22. Dystonia

23. Epilepsy: Invasive Monitoring

24. Epilepsy: Mesial Temporal

25. Epilepsy: Neocortical

26. Pediatric Epilepsy

27. Epilepsy: Neuromodulation

28. Treatment-Resistant Depression: Deep Brain Stimulation

29. Obsessive-Compulsive Disorder: Deep Brain Stimulation

30. Obsessive-Compulsive Disorder: Lesions

31. Gilles de la Tourette Syndrome: Deep Brain Stimulation

32. Chronic Pain: Neuromodulation

33. Chronic Pain: Lesions

34. Cluster Headache: Deep Brain Stimulation

Part V. Diseases and Targets

35. Developing New Indications: Strategies and Hurdles to Discovery

36. Imaging: Patient Selection, Targeting, and Outcome Biomarkers

37. The Design of Clinical Studies for Neuromodulation

38. Registries and Big Data

Back Matter