Ocular Oncology

Book Description:

Survival rates in cases of uveal melanoma and retinoblastoma - the leading intraocular malignancies in adults and children - may be high, but means of earlier diagnosis and improved treatment options are needed to preserve vision and prevent metastasis. This reference deals principally with the molecular biology and genetic factors which trigger and promote the two most common ocular tumours.

Table of Contents:

1. Clinical Overview of Uveal Melanoma: Introduction to Tumors of the Eye

2. Clinical Overview: Retinoblastoma

3. Epidemiology of Uveal Melanoma: Patient Characteristics, Risk Factors, and Predisposing Elements

4. Epidemiology of Retinoblastoma

5. Genetics of Uveal Melanoma: Chromosomal Rearrangements and the Identification of Genes Involved in Tumorigenesis

 6. Structural Alterations and Gene Expression in the Pathogenesis of Uveal Melanoma

7. A Cascade of Genomic Changes Leads to Retinoblastoma

8. The Role of the Retinoblastoma Protein in Health, Malignancy, and the Pathogenesis of Retinoblastoma

9. Biochemical Pathways: Differential Gene Expression and Cellular Pathways Determining Tumor Phenotype Comparison of Uveal Melanocytes and Uveal Melanoma Cells in Vitro

10. p53 and the Molecular Regulation of Cell Fate in Retinoblastoma

11. Immunology of Uveal Melanoma: Adaptive Antitumor Immunity and the Basis for Immunotherapy

12. Immunology of Uveal Melanoma: Immunosuppressive Factors and the Basis for Immunotherapy

13. Models of Uveal Melanoma: Characterization of Transgenic Mice and Other Animal Models for Melanoma

14. Using Retinoblastoma Models to Develop New Treatment: Vitamin D Analogues

15. Therapy of Uveal Melanoma: Methods and Risk Factors Associated with Treatment

16. The Treatment of Retinoblastoma

17. Clinical Trials in Uveal Melanoma: Patient Characteristics and the Treatment of Intraocular Tumors

18. Clinical Trials in Retinoblastoma

19. Pathology of Uveal Melanoma: Histological Parameters and Patient Prognosis

 20. Retinoblastoma: Pathology and Prognosis

21. Molecular Genetics of Retinoblastoma

22. Genetically Engineered Mouse Models of Retinoblastoma

23. Treatment of Extraocular Retinoblastoma