Liver Diseases: A Multidisciplinary Textbook

 About this Textbook

This book provides an in-depth coverage not only of liver pathology but also of diagnosis of the numerous types of liver disease, placing specific emphasis on current treatments of liver pathology including the most up-to-date information on liver transplantation.

The first part of provides an in-depth account of the liver pathology in different conditions such as Hepatits, liver ischaemia reperfusion injury, Lyme disease, cirrhotic cardiomyopathy and hepatocellular carcinoma. The second part provides a comprehensive overview of diagnostic methods. Of particular interest are chapters on the latest techniques in Patient-specific 3D printing and transient elastography (FibroScan). The final part focuses on treatment and provides a step-by step guide to the therapeutic management of liver diseases starting with pharmacological treatment and techniques including surgery and liver transplantation.

 This is an invaluable book  for clinicians, practitioners including academics, scientists/researchers and postgraduates to provide the newest knowledge in the field of liver pathogenesis. It is written by a multidisciplinary team of experts in hepathology, gastroenterology, and surgery especially from liver transplantation.

Table of contents

·  1. Anatomy and Embryology of the Liver

·  2. Liver Histology

·  3. Hepatic Progenitor Cells and Biliary Tree Stem Cells

·  4. Hepatocellular Death: Apoptosis, Autophagy, Necrosis and Necroptosis

·  5. Liver Inflammation: Short Uptodate

·  6. Molecular Basis of Fibrogenesis and Angiogenesis During Chronic Liver Disease: Impact of TGF-β and VEGF on Pathogenic Pathways

·  7. Hepatotoxicity: Mechanisms of Liver Injury

·  8. Crosstalk of Molecular Signaling in Hepatocellular Carcinoma

·  9. Drug Induced Liver Injury: Mechanisms, Diagnosis, and Clinical Management

·  10. Acquired Metabolic Disorders

·  11. Vascular Disorders of the Liver

·  12. Liver Ischaemia-Reperfusion Injury

·  13. Autoimmune Hepatitis

·  14. Primary Sclerosing Cholangitis

·  15. Parasitic Liver Diseases

·  16. Viral Hepatitis B

·  17. Viral Hepatitis C

·  18. Non-B, Non-C Viral Hepatitis

·  19. The Microbiome in Liver Diseases

·  20. Polycystic Liver Diseases

·  21. Hepato- and Porto-pulmonary Hypertension

·  22. Hepatic Abscesses

·  23. Liver Cirrhosis

·  24. Primary Biliary Cholangitis

·  25. The Paucity of Interlobular Bile Ducts

·  26. Nonalcoholic Fatty Liver Disease: A Wide Spectrum Disease

·  27. Alcoholic Liver Disease

·  28. Liver Disease in Pregnancy

·  29. Cirrhotic Cardiomyopathy

·  30. Benign Liver Tumours

·  31. Liver Cancer

·  32. Acute Liver Failure

·  33. Chronic Liver Failure and Acute-on-Chronic Liver Failure

·  Part II. Diagnostic Methods

·  34. History and Physical Examination

·  35. Assessment of Liver Function

·  36. Noninvasive Biomarkers for Liver Fibrosis

·  37. Peritoneal Fluid Analysis

·  38. Measurement of the Hepatic Venous Pressure Gradient (HVPG)

·  39. Liver Biopsy for Histopathology

·  40. Liver Ultrasonography

·  41. Endoscopy in Hepatic Diseases

·  42. Dynamic and Multi-phase Contrast-Enhanced CT Scan

·  43. Patient-Specific 3D Printing in Liver Disease

·  44. Dynamic Contrast-Enhanced Ultrasonography of the Liver

·  45. Ultrasound Elastography

·  46. MR Elastography and Functional MRI of the Liver

·  47. Contrast Enhanced MR imaging of Liver

·  48. Transient Elastography in Chronic Liver Diseases

·  49. Portal Venography

·  50. Minilaparoscopy and Conventional Laparoscopy

·  Part III. Treatment

·  51. Medical Nutrition Therapy in Liver Disease

·  52. Molecular Targets in Liver Disease

·  53. Specific Medications for Chronic Viral Hepatitis

·  54. Portal Vein Embolization (PVE) and Partial TIPE ALPPS: Beyond the Limitations of PVE

·  55. Endoscopic and Pharmacological Treatment of Esophageal Varices

·  56. Procedure for Gastric Variceal Bleeding: From BRTO to PARTO to CARTO, Three Decades of Progress

·  57. Endoscopy and Endoscopic Ultrasound for the Evaluation and Treatment of Gastric and Ectopic Varices

·  58. Portacaval Shunting for Portal Hypertension

·  59. Systemic Therapy of Advanced Liver Cancer

·  60. Embolization Therapy for Liver Cancer

·  61. Ablation of Hepatocellular Carcinoma

·  62. Laparoscopic Liver Resection

·  63. New Loco Regional Approaches to Treat Liver Cancer

·  64. Hepatic Encephalopathy

·  65. Management of Ascites

·  66. Extracorporeal Non cellular Liver Assisted Devices

·  67. Extracorporeal Cellular Liver Assisted Devices

·  68. Liver Transplantation for Acute and Chronic Liver Failure

·  69. Surgical Complications Following Liver Transplant and Their Management

·  70. Anaesthesia for Liver Transplantation

·  71. Surgery in Liver Disease

·  72. Robotic Liver Resection

·  73. Cardiac Surgery Risks in Liver Dysfunction

·  74. Future Approaches in Liver Disorders: Regenerative Medicine