Invasive Studies of the Human Epileptic Brain: Principles and Practice

Description:

No other neurological condition allows the same opportunities for an intracranial electrophysiological study of the human brain as epilepsy does. Epileptic surgery is designed to remove the epileptic focus from the human brain, thereby effecting either cure or substantial reduction of seizures in an individual with an otherwise intractable condition. Its use as a treatment modality dates from the late 19th century, and it has become a widely used treatment option throughout the world in the last 20-30 years. The complexity of epilepsy cases in surgical centres, and the need for invasive electrode studies for pre-surgical evaluation, are both greatly increasing. Invasive Studies of the Human Epileptic Brain is the definitive reference text on the use of invasive electroencephalographic (EEG) diagnostic studies in human epilepsy. Written by some of the most renowned epilepsy experts of the 20th and 21st centuries, the authors provide their expertise and insights into the identification and mapping of intracranial epileptiform and non-epileptiform activity, mapping of the human brain function, and approaches in the use of invasive electroencephalography in a variety of clinical situations. The book is organized into an easily readable series of chapters and is brilliantly illustrated with case studies; each providing an intuitively comprehensive approach to invasive brain studies.

Table of Contents:

Part I: General Overview

1. History of Invasive EEG

2. Principles of Invasive EEG

3. Technical and Practical Aspects of Invasive Recordings and Brain Stimulation

4. Subdural Grid Electrode Placement: Approaches and Complications

5. Depth Electrodes: Approaches and Complications

Part II: Identifying and Mapping Epileptiform and Non-Epileptiform Activity

6. Physiological Activity and artefacts in the Human Epileptic Brain Studied with Intracerebral Depth Electrode EEG

7. Physiological Activity and Artefacts in Epileptic Brain in Subdural EEG

8. The Irritative Zone and Seizure Onset Zone in Subdural EEG

9. The Irritative, Epileptogenic, and Ictal Onset Zones in Depth EEG

10. The Irritative Zone and Seizure Onset Zone in Acute ECoG: The Quest for Relevant Epileptogenic Tissue

11. High-Frequency Oscillations (HFO)

12. Direct Current Shift Recordings

13. Electrical Stimulation for Mapping of the Epileptogenic Zone

14. Invasive EEG and Hippocampal Sclerosis

15. Invasive EEG in Cortical Dysplasia

16. Invasive EEG in Tumoural Epilepsy

17. Invasive EEG in Tuberous Sclerosis

18. Invasive EEG in Grey Matter Heterotopia

19. SEEG in Polymicrogyria: When and How?

20. Invasive EEG in Hypothalamic Hamartoma

Part III: Invasive EEG approaches in specific clinical situations

21. SEEG in Temporal Lobe Epilepsy

22. Subdural EEG in Temporal Lobe Epilepsy

23. SEEG in Frontal Lobe Epilepsy

24. Subdural EEG in Frontal Lobe Epilepsy

25. SEEG in Posterior Cortex Epilepsies

26. Subdural EEG in Posterior Cortex Epilepsy

27. Invasive EEG Investigation of the Insula

28. Depth EEG in Sensorimotor Cortex Epilepsy

29. Invasive Studies of Sensorimotor Cortex Epilepsy

Part IV: Human Brain Mapping

30. Human Brain Mapping Using Subdural Electrodes

31. Intracranial Event-Related Potentials

32. Cortico-Cortical Evoked Potential Mapping

33. Dynamic Spectral Imaging: Online and Offline Functional Brain Mapping Using High-Frequency Activity [50–150 Hz] in SEEG

Part V: Therapy Using Invasive EEG

34. Thermocoagulation of the Ictal Onset Zone Using SEEG (Thermo-SEEG)

35. Therapeutic Stimulation of the Ictal Onset Zone

Part VI: Special Techniques and Future Prospects

36. Simultaneous Macro- and Microrecordings

37. Fast Analytical Sensing Technology: Microelectrode-Based Recordings of Tonic and Phasic Neurotransmitter Signalling in the Mammalian Brain

38. Mapping of Seizure Networks

39. SEEG Recordings: From Signal Processing to Models of Epileptogenic Networks

Index of Authors

Index