Diagnostic Assessment and Treatment of Peripheral Nerve Tumors

Description:

Tumors involving peripheral nerves may be extremely challenging lesions to diagnose and treat.  In order to optimize their management,  physicians should have a thorough knowledge of peripheral nerve anatomy and pathology (both gross and microscopic), as well as familiarity with microsurgical techniques and intraoperative neurophysiological recording. This  compendium deals with all aspects of tumors affecting peripheral nerves,  from diagnosis to treatment; the topics it addresses range  from epidemiology, anatomy, physiology, pathology, and clinical diagnosis to electrophysiology, imaging, genetic/cytomolecular aspects. Surgical approaches, biopsies and resection of various benign, malignant and pseudo-tumoral lesions, plexus tumors (both brachial and lumbosacral), and adjunctive treatment modalities and pain-related issues are described in detail.The  book is intended not only for neurosurgeons, hand surgeons, plastic and orthopedic surgeons new to the field, but also for seasoned specialists who wish to update their knowledge with new insights based on robust experimental and clinical material.  In addition, it will be a helpful tool for general and oncological surgeons who are sometimes faced with  the treatment of mass lesions that may be potential  nerve tumors, and for  all practitioners who are engaged in the arduous struggle to bring relief to patients affected by these lesions.

Table of Contents:

Part I. General Clinical and Surgical Principles in Peripheral Nerve Tumors

1. Epidemiology of Peripheral Nerve Sheath Tumors

2. Genetics of Nerve Tumors

3. Pathological Basis for Classification (Cytomolecular Aspects)

4. Clinical Assessment

5. Preoperative Neurophysiological Evaluation

6. Ultrasound Imaging

7. Magnetic Resonance Neurography

8. X-Ray, Computed Tomography (CT), Positron Emission Tomography (PET) Imaging, and Intraoperative Imaging Adjuncts in the Evaluation and Treatment of Peripheral Nerve Tumors

9. Indications and Techniques for Preoperative Biopsy in Peripheral Nerve Tumors

10. Fundamental Aspects of the Surgical Techniques for the Resection of Peripheral Nerve Tumors

11. Neurophysiological Monitoring during Surgery

12. Complications after Tumor Resection

13. Management of Painful Conditions Associated with Nerve Tumors

14. Indications for Radiotherapy and Chemotherapy in Malignant Tumors

Part II. Peripheral Nerve Tumors in the General Population

15. Schwannomas of the Extremities

16. Neurofibromas

17. Perineuriomas

18. Non-neurogenic Tumoral and Pseudotumoral Lesions Affecting Peripheral Nerve

19. Malignant Peripheral Nerve Sheath Tumors

20. Management of Brachial Plexus Tumors

21. Management of Lumbosacral Plexus Tumors

22. Management of Paraspinal Nerve Sheath Tumors

23. Nerve Tumors of Childhood and Infancy

Part III. Peripheral Nerve Tumors in Genetic Diseases

24. Epidemiology of Genetic Diseases with Peripheral Nerve Tumors

25. A General Introduction to Neurofibromatosis

26. Genetic Aspects of Peripheral Nervous System Tumors

27. Clinical Management of NF1 and Indications for Surgery

28. Plexiform Tumors

29. Management of MPNST in Neurofibromatosis

30. Schwannomatosis: Review of Diagnosis and Management