Central Nervous System Metastases. Diagnosis and Treatment

Description:

This is a multi-specialty book on the diagnosis, evaluation, and treatment of CNS metastases of the brain and spine. Written by renowned experts in their fields, the book covers essential contemporary topics in CNS metastases care. The book is divided into seven parts that begin with chapters that cover the fundamental biology of disease so that subsequent chapters on imaging, diagnosis, treatment, and palliation can be properly contextualized. This text also provides a framework for understanding the biology of radiation therapy so that radiation treatment options of the brain and spine can be more fully understood. New medications and technologies are reviewed from the perspective of maximizing efficacy and minimizing toxicity, independently and as combinatorial therapy. Central Nervous System Metastases: Diagnosis and Treatment serves as a practical reference for health care providers and trainees. It provides the comprehensive, detailed perspective required to provide holistic care to patients with metastatic disease to the brain and spin

Table of Contents:

Part I. Fundamentals

1. Epidemiology and Socioeconomic Impact of CNS Metastases

2. Basic Biology of Brain Metastasis

3. Preclinical Models of Brain Metastasis

4. Pathology of Brain Metastases

5. Role of Precision Medicine in Patients with CNS Metastasis

6. Classification of Brain Metastases

7. The Role of Advanced Imaging in the Management of Brain Metastases

Part II. Evaluation of CNS Metastasis

8. Clinical Presentation of Central Nervous System Metastases

9. Management of Seizures in Brain Metastases

10. Cerebrovascular Complications in Patients with Cancer

11. Mood Disorders in Patients with CNS Metastases

12. Leptomeningeal Disease and the Role of Intrathecal Therapy

13. Paraneoplastic Neurological Disorders

14. Systemic Therapy of Brain Metastases: Lung Cancer

15. Systemic Therapy of Brain Metastases: Breast Cancer

16. Systemic Therapy for Brain Metastases: Melanoma

17. Systemic Therapy for Brain Metastases in Other Primary Cancers (Genitourinary, Gastrointestinal, Gynecology, Head/Neck)

18. Management of Solid Tumor CNS Metastases in Children

Part III. Radiation Therapy of CNS Metastasis

19. Basic Radiobiology and Radiation Physics Primer

20. Role of Whole-Brain Radiotherapy

21. Stereotactic Radiosurgery Technology

22. Stereotactic Radiosurgery: Indications and Outcomes in Central Nervous System and Skull Base Metastases

23. Hypofractionated Stereotactic Radiosurgery (HF-SRS) in the Treatment of Brain Metastases

24. Challenges and Controversies in Stereotactic Radiosurgery

25. Synergy of Immunotherapy and Radiosurgery

26. Salvage Irradiation for Patients with Recurrent Brain Metastases

27. Applications of Stereotactic Radiosurgery for Brain Metastases

28. Radiation Necrosis Following the Radiosurgical Treatment of Brain Metastases

29. Neurocognitive Effects of Brain Metastases and Their Treatment

Part IV. Surgical Treatment of Brain Metastasis

30. The Role of Surgery in the Management of Brain Metastases

31. Intraoperative Brachytherapy for Resected Brain Metastases

32. Laser Interstitial Thermal Therapy for Brain Metastases and Radiation Necrosis

33. Preventing Cranial Wound Complications in Cancer Patients

Part V. Spinal Metastases: Foundations

34. Introduction to Spinal Metastases

35. Epidemiology of Spinal Metastatic Disease

36. Bone Metabolism in Cancer

37. Systemic Therapies for Patients with Metastatic Spinal Disease

38. The Role of Advanced Imaging in Spinal Metastases

39. Decision-Making Algorithms for Surgical Treatment of Spine Metastatic Disease

Part VI. Surgical Treatment of Spinal Metastases

40. Biomechanics of Spinal Fixation in Metastatic Disease

41. Separation Surgery for Spinal Metastases

42. Vertebrectomy for Spinal Metastases

43. Minimally Invasive Surgery for Spinal Metastases

44. Deformity Secondary to Vertebral Body Metastases

45. Postoperative Complications and Spinal Metastases

46. Vertebral Augmentation Procedures for Treatment of Pathologic Vertebral Body Fractures

47. Spinal Laser Interstitial Thermal Therapy for Metastatic Tumors

48. Optimizing Wound Healing in Metastatic Spine Surgery

49. Contemporary Radiation for Spinal Metastasis and Spinal Cord Compression

50. Intraoperative Radiation for Spinal Metastatic Disease

Part VII. Pain

51. Approach to Pain in Patients with Central Nervous System Metastases

52. Interventions for Refractory Pain in Cancer Patients

53. Complementary and Integrative Therapies (CIM) in Patients with CNS Metastasis

54. The Palliative Care of Patients with Brain Metastases

Back Matter