The Washington Manual of Hematopathology

 

Continuing in the rich tradition of this popular handbook series, The Washington Manual® of Hematopathology provides concise, high-yield content that reflects today’s fast-changing advances in the field. Edited by Drs. Brooj Abro, John L. Frater, Louis P. Dehner, John D. Pfeifer, and Anjum Hassan, this all-new volume focuses on the essential information you need to know, using a concise format, along with numerous figures, tables, algorithms, and images throughout. In one convenient, portable resource, you’ll find complete coverage of hematopathology—both benign and malignant entities—all at your fingertips for quick review and reference.

 

Table of Contents:

 

I Introduction to Hematopathology

1. Normal Anatomy

1.1 Blood, Bone Marrow, and Thymus

I. BLOOD COMPONENTS

II. BONE MARROW ARCHITECTURE

III. HEMATOPOIESIS

IV. MATURATION OF HEMATOPOIETIC LINEAGES

V. NON-HEMATOPOIETIC CELLS

VI. THYMUS

1.2 Lymph Node

I. LYMPH NODE ARCHITECTURE

II. NORMAL VARIATIONS IN LYMPH NODE MORPHOLOGY

III. FUNCTION

1.3 Spleen

I. GROSS ANATOMY

II. MICROSCOPIC ANATOMY

III. FUNCTION

IV. GROSS EXAMINATION AND TISSUE PROCESSING

2. Approach to the Bone Marrow and Lymph Node Biopsy

I. TISSUE SAMPLING, PROCESSING, AND GROSS EXAMINATION

II. APPROACH TO THE BONE MARROW BIOPSY

III. APPROACH TO THE LYMPH NODE BIOPSY

3. Approach to Fine Needle Aspiration of Hematologic Malignancies

I. INTRODUCTION TO FINE NEEDLE ASPIRATION

II. THE ROLE OF FINE NEEDLE ASPIRATION IN HEMATOLOGIC MALIGNANCIES

III. THE APPROACH TO FINE NEEDLE ASPIRATION IN HEMATOLOGIC MALIGNANCIES

II Non-neoplastic

4. Peripheral blood

4.1: Red Blood Cell Disorders

I. Normal Red Blood Cell Rheology

II. Nutritional Anemias

III. Red Blood Cell Enzyme Deficiency

IV. Cell Membrane Disorders

V. Immune Hemolytic Anemias

VI. Disorders of Hemoglobin

4.2: White Blood Cell Disorders

I. Neutrophils

II. Lymphocytes

III. Other Morphologic White Blood Cell Abnormalities

4.3: Platelet Disorders

I. Laboratory Assessment of Platelets

II. Acquired Disorders of Platelet Number

III. Acquired Nonneoplastic Disorders of Platelet Size and Morphology

IV. Inherited Disorders of Platelet Number, Morphology, and Function

5. Bone marrow

5.1 Bone Marrow Abnormalities in Systemic Conditions

I. BACTERIAL INFECTIONS

II. PARASITIC AND PROTOZOAL INFECTIONS

III. FUNGAL INFECTIONS

III. VIRAL INFECTIONS

IV. LIPID STORAGE DISORDERS

V. OTHER SYSTEMIC CONDITIONS

5.2 Bone Marrow Failure Syndromes

I. ACQUIRED CAUSES OF BONE MARROW FAILURE

II. INHERITED BONE MARROW FAILURE SYNDROMES

6. Lymph node

6.1: Reactive Lymphoid Hyperplasia and Benign Noninfectious Lymphadenopathies

I. REACTIVE LYMPHOID HYPERPLASIA PATTERNS

II. DERMATOPATHIC LYMPHADENOPATHY

III. INDOLENT B- AND T-LYMPHOBLASTIC PROLIFERATIONS

IV. RECTAL TONSIL

V. LYMPHOMA-LIKE LESIONS OF THE FEMALE GENITAL TRACT

VI. PROGRESSIVE TRANSFORMATION OF GERMINAL CENTERS

VII. KIKUCHI-FUJIMOTO DISEASE

VIII. KIMURA DISEASE

IX. IMMUNOGLOBULIN G4-RELATED DISEASE ASSOCIATED LYMPHADENOPATHY

X. Castleman Disease

XI. AUTOIMMUNE DISEASE-ASSOCIATED LYMPHADENOPATHY

6.2 Infectious Lymphadenopathies

I. VIRAL LYMPHADENITIS

II. BACTERIAL LYMPHADENITIS

III. OTHER INFECTIOUS LYMPHADENITIS

7. Spleen

7.1 Nonneoplastic Disorders of the Spleen

I. CONGENITAL ANOMALIES

II. SPLENIC TRAUMA

III. SPLENOMEGALY

IV. DISORDERS OF SPLENIC FUNCTION

V. REACTIVE SPLENIC DISORDERS

VI. STORAGE DISEASES COMMONLY INVOLVING THE SPLEEN

7.2 Non-hematopoietic Tumors and Tumor-Like Lesions of the Spleen

I. VASCULAR TUMORS

II. PSEUDONEOPLASTIC LESIONS

III. METASTATIC TUMORS

IV. OTHER NEOPLASMS

III Neoplastic

Part 1: Myeloid Neoplasms

8. Overview and Classification of Myeloid Neoplasms

I. OVERVIEW OF CHANGES IN MYELOPROLIFERATIVE NEOPLASMS

II. OVERVIEW OF MYELOID PRECURSOR LESIONS

III. OVERVIEW OF CHANGES IN MYELODYSPLASTIC SYNDROME

IV. OVERVIEW OF CHANGES IN MYELODYSPLASTIC SYNDROMES/MYELOPROLIFERATIVE NEOPLASMS

V. OVERVIEW OF ACUTE MYELOID LEUKEMIA AND RELATED PRECURSOR NEOPLASMS

VI. OVERVIEW OF SECONDARY MYELOID NEOPLASMS

VII. OVERVIEW OF CHANGES IN MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND GENE REARRANGEMENTS

IX. OVERVIEW OF CHANGES IN MASTOCYTOSIS

X. OVERVIEW OF PLASMACYTOID DENDRITIC CELL NEOPLASM

9. Myeloproliferative Neoplasms

I. CHRONIC MYELOID LEUKEMIA

II. POLYCYTHEMIA VERA

III. PRIMARY MYELOFIBROSIS

IV. ESSENTIAL THROMBOCYTHEMIA

V. JUVENILE MYELOMONOCYTIC LEUKEMIA

VI. OTHER MYELOPROLIFERATIVE NEOPLASMS

10. Myeloid Precursor Lesions and Myelodysplastic Syndromes/Neoplasms

I. MYELOID PRECURSOR LESIONS

II. MYELODYSPLASTIC NEOPLASMS

11. Myelodysplastic/Myeloproliferative Neoplasms

I. CHRONIC MYELOMONOCYTIC LEUKEMIA

II. MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASM WITH NEUTROPHILIA

III. MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASM WITH SF3B1 MUTATION AND THROMBOCYTOSIS

IV. MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASM, NOS

12. Acute Myeloid Leukemia

I. Acute Myeloid Leukemia: Introduction and Overview

II. Classification of Acute Myeloid Leukemia: World Health Organization and International Consensus Classification

III. Acute Myeloid Leukemia With Defining Genetic Abnormalities

IV. Acute Myeloid Leukemia, Myelodysplasia Related and Acute Myeloid Leukemia With Mutated TP53

V. Acute Myeloid Leukemia Defined by Differentiation/Acute Myeloid Leukemia-Not Otherwise Specified

VI. Myeloid Sarcoma

13. Secondary Myeloid Neoplasms

I. CLASSIFICATION OF SECONDARY MYELOID NEOPLASMS (WHO-HAEM5 AND ICC)

II. MYELOID NEOPLASMS POST-CYTOTOXIC THERAPY

III. MYELOID NEOPLASMS ASSOCIATED WITH GERMLINE PREDISPOSITION

IV. MYELOID PROLIFERATIONS ASSOCIATED WITH DOWN SYNDROME

ACKNOWLEDGMENTS

14. Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions

I. GENERAL FEATURES OF M/LN-eo-TK

II. M/LN-eo-TK WITH PDGFRA REARRANGEMENT

III. M/LN-eo-TK With PDGFRB Rearrangement

IV. M/LN-eo-TK WITH FGFR1 REARRANGEMENT

V. M/LN-eo-TK WITH JAK2 REARRANGEMENT

VI. M/LN-eo-TK WITH FLT3 REARRANGEMENT

VII. M/LN-eo-TK With ETV6::ABL1 Fusion

VIII. M/LN-eo-TK WITH OTHER TK GENE FUSIONS

15. Mastocytosis

I. CUTANEOUS MASTOCYTOSIS

II. SYSTEMIC MASTOCYTOSIS

III. MAST CELL SARCOMA

16. Plasmacytoid Dendritic Cell Neoplasms

I. BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM

II. MATURE PLASMACYTOID DENDRITIC CELL PROLIFERATION ASSOCIATED WITH MYELOID NEOPLASM

Part 2: Lymphoid Neoplasms

17. Overview and Classification of Lymphoid Neoplasms

I. OVERVIEW OF B-CELL LYMPHOID PROLIFERATIONS AND LYMPHOMAS

II. OVERVIEW OF TUMOR-LIKE LESIONS WITH B-CELL PREDOMINANCE

III. OVERVIEW OF ACUTE LEUKEMIA/LYMPHOMAS

IV. OVERVIEW OF MATURE B-CELL LYMPHOMAS

V. OVERVIEW OF HODGKIN LYMPHOMA

VI. OVERVIEW OF PLASMA CELL NEOPLASMS AND OTHER DISEASES WITH PARAPROTEINS

VII. OVERVIEW OF T CELL LYMPHOMAS

18. Precursor Lymphoid Neoplasms and Leukemias of Ambiguous Lineage

18.1 B-Lymphoblastic Leukemia/Lymphoma

18.2 T-Lymphoblastic Leukemia/Lymphoma

I. T-LYMPHOBLASTIC LEUKEMIA/LYMPHOMA, NOS

II. EARLY T-PRECURSOR LYMPHOBLASTIC LEUKEMIA/LYMPHOMA

III. NK-LYMPHOBLASTIC LEUKEMIA/LYMPHOMA

18.3 Acute Leukemias of Mixed or Ambiguous Lineage

I. ACUTE LEUKEMIA OF AMBIGUOUS LINEAGE WITH DEFINING GENETIC ABNORMALITIES

II. ACUTE LEUKEMIA OF AMBIGUOUS LINEAGE, IMMUNOPHENOTYPICALLY DEFINED

III. MIXED-PHENOTYPE ACUTE LEUKEMIA, RARE TYPES

IV. ACUTE UNDIFFERENTIATED LEUKEMIA

19. Mature B-cell and Plasma Cell Neoplasms

19.1 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Monoclonal B-Cell Lymphocytosis, and B-Cell Prolymphocytic Leukemia

I. CHRONIC LYMPHOCYTIC LEUKEMIA/SMALL LYMPHOCYTIC LYMPHOMA

II. MONOCLONAL B-CELL LYMPHOCYTOSIS

III. B-CELL PROLYMPHOCYTIC LEUKEMIA

19.2 Extranodal, Nodal, and Pediatric Nodal Marginal Zone Lymphoma

I. MARGINAL ZONE LYMPHOMA GENERAL FEATURES

II. EXTRANODAL MARGINAL ZONE LYMPHOMA OF MUCOSA-ASSOCIATED LYMPHOID TISSUE

III. NODAL MARGINAL ZONE LYMPHOMA

IV. PEDIATRIC NODAL MARGINAL ZONE LYMPHOMA

19.3 Lymphoplasmacytic Lymphoma

19.4 Splenic B-Cell Leukemias/Lymphomas

I. HAIRY CELL LEUKEMIA

II. SPLENIC MARGINAL ZONE LYMPHOMA

III. SPLENIC DIFFUSE RED PULP SMALL B-CELL LYMPHOMA/LEUKEMIA

IV. SPLENIC B-CELL LYMPHOMA/LEUKEMIA WITH PROMINENT NUCLEOLI

V. DIFFERENTIAL DIAGNOSIS OF SPLENIC B-CELL LEUKEMIAS/LYMPHOMAS

19.5 Follicular Lymphoma

I. FOLLICULAR LYMPHOMA

II. DUODENAL-TYPE FOLLICULAR LYMPHOMA

III. PEDIATRIC-TYPE FOLLICULAR LYMPHOMA

IV. IN SITU FOLLICULAR B-CELL NEOPLASM

19.6 Mantle Cell Lymphoma

I. MANTLE CELL LYMPHOMA

II. LEUKEMIC NON-NODAL MANTLE CELL LYMPHOMA

III. IN SITU MANTLE CELL NEOPLASM

19.7 Large B-Cell Lymphomas

I. DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED

II. LARGE B-CELL LYMPHOMA WITH IRF4 REARRANGEMENT

III. High-Grade B-Cell Lymphomas

IV. Large B-Cell Lymphomas With Polymorphic Pattern

V. LARGE B CELL LYMPHOMAS ASSOCIATED WITH SPECIFIC ANATOMIC SITES

VI. LARGE B-CELL LYMPHOMAS WITH PLASMABLASTIC FEATURES

VII. Large B-Cell Lymphomas Confined to Natural or Acquired Body Spaces

19.8 Burkitt Lymphoma

19.9 Kaposi Sarcoma Associated Herpes Virus (KSHV)/Human Herpesvirus 8 (HHV8) Associated B-Cell Proliferations and Lymphomas

I. KAPOSI SARCOMA–ASSOCIATED HERPESVIRUS/HUMAN HERPESVIRUS-8–ASSOCIATED MULTICENTRIC CASTLEMAN DISEASE

II. PRIMARY EFFUSION LYMPHOMA

III. KSHV/HHV8–POSITIVE DIFFUSE LARGE B-CELL LYMPHOMA

IV. KAPOSI SARCOMA–ASSOCIATED HERPESVIRUS/HUMAN HERPESVIRUS-8–POSITIVE GERMINOTROPIC LYMPHOPROLIFERATIVE DISORDER

19.10 Primary Cutaneous B-Cell Lymphoproliferative Disorders/Lymphomas

I. PRIMARY CUTANEOUS MARGINAL ZONE LYMPHOMA

II. PRIMARY CUTANEOUS DIFFUSE LARGE B-CELL LYMPHOMA, LEG TYPE

III. PRIMARY CUTANEOUS FOLLICLE CENTER TYPE LYMPHOMA

IV. EPSTEIN-BARR VIRUS–POSITIVE MUCOCUTANEOUS ULCER

19.11 Plasma Cell Neoplasms and Other Diseases Associated With Paraproteins

I. MONOCLONAL GAMMOPATHIES

II. DISEASES WITH MONOCLONAL IMMUNOGLOBULIN DEPOSITION

III. HEAVY CHAIN DISEASES

20. Hodgkin Lymphomas

20.1 Nodular Lymphocyte-Predominant Hodgkin Lymphoma

20.2 Classic Hodgkin Lymphoma

21. Mature T/NK-cell Neoplasms

21.1 Mature T-/NK-Cell Leukemias

I. T-Cell Prolymphocytic Leukemia

II. T-Cell Large Granular Lymphocytic Leukemia

III. NK-Cell Large Granular Lymphocytic Leukemia

IV. Aggressive NK-Cell Leukemia

V. Adult T-Cell Leukemia/Lymphoma

21.2 Intestinal T/NK-Cell Lymphoproliferative Disorders and Lymphomas

I. Indolent T-Cell Lymphoma of the Gastrointestinal Tract

II. Indolent Natural Killer Cell Lymphoproliferative Disorder of the Gastrointestinal Tract

III. Enteropathy-Associated T-Cell Lymphoma

Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma

IV. Intestinal T-Cell Lymphoma, NOS

21.3 Hepatosplenic T-Cell Lymphoma

21.4 Epstein Bar Virus-Positive NK-/T-Cell Lymphomas

I. Extranodal NK-/T-Cell Lymphoma

II. EBV-POSITIVE NODAL T-/NK-CELL LYMPHOMA

21.5 Anaplastic Large Cell Lymphomas

I. Anaplastic Lymphoma Kinase–Positive Anaplastic Large Cell Lymphoma

II. Anaplastic Lymphoma Kinase–Negative Anaplastic Large Cell Lymphoma

III. Breast Implant–Associated Anaplastic Large Cell Lymphoma

21.6 Primary Cutaneous T-Cell Lymphoproliferative Disorders/Lymphomas

I. Mycosis Fungoides

II. Sézary Syndrome

III. Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders

IV. Subcutaneous Panniculitis-Like T-Cell Lymphoma

V. Primary Cutaneous γδ T-Cell Lymphoma

VI. Primary Cutaneous Aggressive Epidermotropic CD8+ Cytotoxic T-Cell Lymphoma

VII. Primary Cutaneous Acral CD8-Positive T-Cell Lymphoproliferative Disorder

VIII. Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoproliferative Disorder

IX. Cutaneous Peripheral T-Cell Lymphoma, Not Otherwise Specified

21.7 Lymphomas of T Follicular Helper Cell Origin

I. Nodal T Follicular Helper Cell Lymphoma, Angioimmunoblastic Type

II. Nodal T Follicular Helper Cell Lymphoma, Follicular Type

III. Nodal T Follicular Helper Lymphoma, Not Otherwise Specified

21.8 Peripheral T-Cell Lymphoma, Not Otherwise Specified

21.9 Epstein Bar Virus-Positive NK-/T-Cell Lymphoproliferative Diseases of Childhood

I. Severe Mosquito Bite Allergy

II. Hydroa Vacciniforme Lymphoproliferative Disorder

III. Systemic Chronic Active Epstein-Barr Virus Disease

IV. Systemic Epstein-Barr Virus–Positive T-Cell Lymphoma of Childhood

Part 3: Immunodeficiency-Associated Lymphoproliferative Disorders

22. Overview and Classification of Immunodeficiency-Associated Lymphoproliferative Disorders

I. CLASSIFICATION OF IMMUNODEFICIENCY-ASSOCIATED LYMPHOPROLIFERATIVE DISORDERS ACCORDING TO THE WHO-HAEM4R

II. UPDATES TO THE CLASSIFICATION OF IMMUNODEFICIENCY-ASSOCIATED LYMPHOPROLIFERATIVE DISORDERS

23. Lymphoid Proliferations and Lymphomas Associated With Immune Deficiency/Dysregulation

I. HYPERPLASIAS ARISING IN SETTINGS OF IMMUNE DEFICIENCY/DYSREGULATION

II. POLYMORPHIC LYMPHOPROLIFERATIVE DISORDERS ARISING IN IMMUNE DEFICIENCY/DYSREGULATION

III. LYMPHOMAS ARISING IN IMMUNE DEFICIENCY/DYSREGULATION

24. Inborn Error of Immunity–Associated Lymphoid Proliferations and Lymphomas

Part 4: Histiocytic and Dendritic Cell Neoplasms

25. Introduction to Histiocytic and Dendritic Cell Neoplasms

I. “L” (LANGERHANS) GROUP

II. “C” GROUP: CUTANEOUS AND MUCOCUTANEOUS HISTIOCYTOSES

III. “M” GROUP: MALIGNANT HISTIOCYTOSES

IV. “R” GROUP: ROSAI-DORFMAN DISEASE AND MISCELLANEOUS NONCUTANEOUS, NON–LANGERHANS CELL HISTIOCYTOSES

V. “H” GROUP: HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS AND MACROPHAGE ACTIVATION SYNDROME

SUMMARY

26. Histiocytic Sarcoma

27. Langerhans Cell Tumors

28. Juvenile Xanthogranuloma

29. Rosai-Dorfman Disease

30. Other Histiocytic/Dendritic Cell Neoplasms

30.1 Dendritic Cell and Dendritic Cell–Like Neoplasms

I. INDETERMINATE DENDRITIC CELL TUMOR

II. INTERDIGITATING DENDRITIC CELL SARCOMA

III. DENDRITIC CELL–LIKE TUMORS (STROMAL-DERIVED NEOPLASMS OF LYMPHOID TISSUES)

IV. FOLLICULAR DENDRITIC CELL SARCOMA

V. EBV-POSITIVE INFLAMMATORY FOLLICULAR DENDRITIC CELL SARCOMA

VI. FIBROBLASTIC RETICULAR CELL TUMOR

30.2 Erdheim-Chester Disease

30.3 ALK-Positive Histiocytosis

IV Ancillary Techniques

31. Immunohistochemistry and Histochemistry

I. IMMUNOHISTOCHEMISTRY

II. INTERPRETATION

III. IN SITU HYBRIDIZATION TECHNIQUES

IV. HISTOCHEMICAL STAINS

32. Flow Cytometry

I. Basic Principles

II. Instrumentation

III. Types of Assays

IV. Gating and Interpretation

V. Background Signals and Artifacts

VI. Reporting of Leukemia/Lymphoma Flow Cytometry Interpretations

VII. Immunophenotyping for Leukemia/Lymphoma Characterization

VIII. Minimal/Measurable Residual Disease Flow Cytometry

IX. Common Cell Antigens Used in Clinical Flow Cytometry

33. Cytogenomics

I. TRADITIONAL CYTOGENETIC ANALYSIS

II. METAPHASE FLUORESCENCE IN SITU HYBRIDIZATION

III. MULTIPLEX METAPHASE FLUORESCENCE IN SITU HYBRIDIZATION

IV. COMPARATIVE GENOMIC HYBRIDIZATION

V. MICROARRAY ANALYSIS

VI. HUMAN CHROMOSOME NOMENCLATURE

ACKNOWLEDGMENTS

34. Molecular Diagnostics

34.1 Interphase Fluorescence In Situ Hybridization

I. FISH Applications and Probe Types

II. Interphase FISH Nomenclature

III. Limitations

IV. Use of Interphase FISH Versus Other Molecular Techniques

34.2 Polymerase Chain Reaction and Related Techniques

I. Specimen Requirements, Handling, and Processing

II. General Features of Polymerase Chain Reaction–Based Nucleic Acid Analysis

III. Basic Polymerase Chain Reaction Methodology

IV. Applications of Polymerase Chain Reaction

V. Sequence Analysis by Sanger Sequencing

VI. Identity Determination

VII. Clonality Assays

34.3 Next-Generation Sequencing

I. NGS METHODOLOGIES

II. NGS ASSAY SCOPE/TYPES OF NGS ASSAYS

III. BIOINFORMATICS

IV. REPORTING

V. RNA SEQUENCE ANALYSIS

VI. CLONALITY ASSAYS

VII. HUMAN LEUKOCYTE ANTIGEN TYPING

VIII. LIQUID BIOPSIES

Index

 

An aparitie	7 sep 2024
Autor	Brooj Abro MD, Anjum Hassan MD, John D. Pfeifer MD, PhD, Louis P. Dehner MD
Editura	LWW
Format	Paperback
ISBN	9781975199234
Limba	Engleza
Nr pag	640
Versiune digitala	DA