Diagnostic Pathology: Blood and Bone Marrow

Description:

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of nonneoplastic and neoplastic conditions of blood and bone marrow, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Blood and Bone Marrow is a visually stunning, one-stop resource for every practicing pathologist, hematopathologist, oncologist, hematologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource. 

Features:

• Provides practicing pathologists with key details about new entities, newly recognized causes of morphologic change in blood and bone marrow abnormalities, and new strategies for appropriate workup of neoplastic processes—all with a focus on key tests and key differential diagnostic considerations 
• Helps pathologists recognize unique blood and bone marrow findings that can be an indicator for specific exposures, such as new medications, new targeted therapies, or toxins 
• Integrates updated technologies, newly recognized disorders, complications/features in blood and bone marrow, new targeted therapies, and the increased use of homeopathic remedies 
• Contains new chapters covering SARS-CoV-2 infection features in blood and bone marrow; myelodysplastic syndrome (MDS) mimics; blood and bone marrow findings linked to targeted therapies; blood and bone marrow findings linked to other medications; and more 
• Updates all existing chapters and contains expanded information on T-cell neoplasms in blood and bone marrow and intravascular large B-cell lymphoma in blood and bone marrow  
• Includes details from the WHO’s fifth edition Classification of Tumours of Haematopoietic and Lymphoid Tissues as well as the International Consensus Classification of Hematolymphoid Neoplasms, reflecting new and renamed diagnostic entities, tumor classification changes and updates, and terminology changes and updates 
• Discusses molecular testing strategies based on specific neoplasms and specific differential diagnostic consideration 
• Clearly delineates numerous genetic disorders often found in blood and bone marrow 
• Features nearly 2,600 superb images (many new or updated), including histology and gross pathology photographs, full-color illustrations and schematics, clinical photographs, and radiologic images 
• Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care 
• Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices 

Table Of Contents:

2 Introduction     
3  Hematopoiesis and Bone Marrow Histology     
4  Bone Marrow Examination and Techniques     
5  Synoptic Bone Marrow Reporting     
6  Overview of Constitutional and Acquired Bone Marrow Disorders     
7 Anemia      
8  Overview of Anemia     
9  Acquired Anemias     
10   Anemias of Inflammation, Chronic Renal Disease, and Cancer    
11   Iron Deficiency Anemia    
12   Autoimmune Hemolytic Anemias    
13   Alloimmune Hemolytic Anemia and Hemolytic Disease of Newborn    
14   Microangiopathic Hemolytic Anemia    
15   Megaloblastic Anemia    
16   Acquired Nonneoplastic Sideroblastic Anemia    
17   Alcoholism-Associated Anemia    
18   Anemia in the Elderly    
19   Copper Deficiency-Associated Anemia    
20   Acquired Red Cell Aplasia    
21   Transient Erythroblastopenia of Childhood    
22   Parvovirus-Induced Red Cell Aplasia    
23   Paroxysmal Nocturnal Hemoglobinuria    
24   Acquired Aplastic Anemia    
25  Constitutional Anemias     
26   Thalassemia    
27   Sickle Cell Anemia    
28   Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency    
29   Pyruvate Kinase Deficiency    
30   Hereditary Spherocytosis    
31   Hereditary Elliptocytosis, Including Hereditary Pyropoikilocytosis    
32   Diamond-Blackfan Anemia    
33   Fanconi Anemia    
34   Congenital Dyserythropoietic Anemia    
35   Congenital Sideroblastic Anemia    
36   Congenital Megaloblastic Anemia    
37 Erythrocytosis      
38  Constitutional     
39   Congenital Erythrocytosis    
40  Acquired     
41   Acquired Erythrocytosis    
42 Benign Leukocyte Disorders in Blood and Bone Marrow      
43  Overview of Benign Leukocyte Disorders in Blood and Bone Marrow     
44  Pancytopenia     
45  Neutropenia     
46  Neutrophilia     
47  Monocytosis     
48  Eosinophilia     
49  Basophilia     
50  Lymphocytosis     
51  Lymphopenia, Constitutional and Acquired     
52  Plasmacytosis of Bone Marrow     
53  Hematogones in Bone Marrow     
54  Lymphoid Aggregates in Bone Marrow     
55  Granulomas in Bone Marrow     
56 Constitutional Granulocytic Disorders      
57  Constitutional Neutropenias     
58   Severe Congenital Neutropenia and Cyclic Neutropenia    
59   Shwachman-Diamond Syndrome    
60   Chediak-Higashi Syndrome    
61   Myelokathexis in WHIM Syndrome    
62  Constitutional Neutrophil Anomalies     
63   Pelger-Huët Anomaly    
64   *MYH9*-Related Disorders    
65   Selected Lysosomal Storage Diseases With Abnormal Leukocyte Granulation    
66 Megakaryocytic Disorders      
67  Overview of Megakaryocytic Disorders     
68  Acquired Platelet Disorders With Thrombocytopenia     
69   Immune-Mediated Thrombocytopenia    
70   Hemolytic-Uremic Syndrome    
71   Heparin-Induced Thrombocytopenia (HIT)    
72   Thrombotic Thrombocytopenic Purpura    
73   Pregnancy-Associated Thrombocytopenia    
74  Constitutional Platelet Disorders With Thrombocytopenia     
75   Macrothrombocytopenia    
76   Thrombocytopenia Absent Radius Syndrome    
77   Congenital Amegakaryocytic Thrombocytopenia    
78   Gray Platelet Syndrome    
79   Wiskott-Aldrich Syndrome-Related Disorders    
80   Congenital Thrombotic Thrombocytopenic Purpura    
81  Thrombocytosis     
82   Thrombocytosis    
83 Infection      
84  Overview of Infection     
85  Hantavirus Pulmonary Syndrome     
86  Human Immunodeficiency Virus     
87  Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus)     
88  Parvovirus B19 Infection     
89  Bacterial Infections, Blood and Bone Marrow Features     
90  Fungal Infections, Blood and Bone Marrow Features     
91  Helminthic Infections     
92  Malaria     
93  Other Protozoan Infections     
94  COVID-19 Infection     
95 Miscellaneous Nonneoplastic Disorders and Conditions      
96  Overview and Classification of Hemophagocytic Disorders in Bone Marrow     
97  Hematologic Manifestations of Collagen Vascular Disorders     
98  Hematologic Manifestations of Chronic Renal Disorders     
99  Lysosomal Storage Diseases With Predominantly Histiocytic Storage     
100  Homeopathic Remedies and Medications Affecting Blood and Bone Marrow     
101  Other Pregnancy-Associated Hematologic Disorders     
102  VEXAS Syndrome     
103  Gelatinous Transformation and Other Bone Marrow Stromal Disorders     
104  Crystals in Bone Marrow     
105  Bone Abnormalities in Bone Marrow Specimens     
106 Myeloid Neoplasms      
107  Overview and Classification of Myeloid Neoplasms     
108  Specialized Testing in Myeloid Neoplasms     
109  Clinical Practice Guidelines for Initial Work-Up of Acute Leukemia     
110  Myeloproliferative Neoplasms     
111   Overview of Myeloproliferative Neoplasms    
112   Chronic Myeloid Leukemia, *BCR-ABL1* Positive    
113   Chronic Neutrophilic Leukemia    
114   Polycythemia Vera    
115   Primary Myelofibrosis    
116   Essential Thrombocythemia    
117   Chronic Eosinophilic Leukemia, Not Otherwise Specified    
118   Myeloproliferative Neoplasm, Unclassifiable    
119  Mastocytosis     
120   Systemic Mastocytosis    
121   Mast Cell Leukemia    
122  Myeloid and Lymphoid Neoplasms With Eosinophilia and Gene Rearrangements     
123   Myeloid and Lymphoid Neoplasms With *PDGFRA* Rearrangement    
124   Myeloid and Lymphoid Neoplasms With *PDGRFB* Rearrangement    
125   Myeloid and Lymphoid Neoplasms With *FGFR1* Rearrangement    
126   Myeloid and Lymphoid Neoplasms With *FLT3* Rearrangement    
127  Myelodysplastic/Myeloproliferative Neoplasms     
128   Overview of Myelodysplastic/Myeloproliferative Neoplasms    
129   Chronic Myelomonocytic Leukemia    
130   Atypical Chronic Myeloid Leukemia, *BCR-ABL1* Negative (aCML)    
131   Juvenile Myelomonocytic Leukemia    
132   Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis    
133   Myelodysplastic/Myeloproliferative Neoplasms, Unclassifiable    
134  Myelodysplastic Syndromes     
135   Overview and Classification of Myelodysplastic Syndromes    
136   Clonal Hematopoiesis of Indeterminant Potential (CHIP)    
137   Myelodysplastic Syndrome With Single Lineage Dysplasia    
138   Myelodysplastic Syndromes With Ring Sideroblasts    
139   Myelodysplastic Syndrome With Multilineage Dysplasia    
140   Myelodysplastic Syndromes With Excess Blasts    
141   Myelodysplastic Syndrome With Isolated del(5q)    
142   Myelodysplastic Syndrome, Unclassifiable    
143   Childhood Myelodysplastic Syndrome (Refractory Cytopenia of Childhood)    
144  Acute Myeloid Leukemia     
145   Overview of Acute Myeloid Leukemia    
146   Familial AML/MDS (Germline Predisposition)    
147   Acute Myeloid Leukemia With t(8;21)(q22;q22.1), *RUNX1-RUNX1T1*    
148   Acute Myeloid Leukemia With inv(16)(p13.1q22) or t(16;16)(p13.1;q22), *CBFB-MYH11*    
149   Acute Promyelocytic Leukemia With *PML-RARA*    
150   Acute Promyelocytic Leukemia With Variant *RARA* Rearrangement    
151   Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3), *KMT2A-MLLT3*    
152   Subtypes of Acute Myeloid Leukemia: t(6;9), inv(3), t(1;22), t(9;22), Mutated *NPM1,* Biallelic Mutated *CEBPA,* Mutated *RUNX1*    
153   Acute Myeloid Leukemia With Myelodysplasia-Related Changes    
154   Therapy-Related Myeloid Neoplasms    
155   Acute Myeloid Leukemia With Minimal Differentiation (AML, NOS)    
156   Acute Myeloid Leukemia Without Maturation (AML, NOS)    
157   Acute Myeloid Leukemia With Maturation (AML, NOS)    
158   Acute Myelomonocytic Leukemia (AML, NOS)    
159   Acute Monoblastic and Monocytic Leukemia (AML, NOS)    
160   Pure Erythroid Leukemia (AML, NOS)    
161   Acute Megakaryoblastic Leukemia, Not Otherwise Specified    
162   Acute Basophilic Leukemia (AML, NOS)    
163   Acute Panmyelosis With Myelofibrosis (AML, NOS)    
164   Myeloid Proliferations Related to Down Syndrome    
165   Measurable Residual Disease Testing Strategies in AML    
166  Blastic Plasmacytoid Dendritic Cell Neoplasm     
167   Blastic Plasmacytoid Dendritic Cell Neoplasm    
168 Acute Leukemias of Ambiguous Lineage      
169  Acute Undifferentiated Leukemia     
170  Mixed Phenotype Acute Leukemia     
171 Lymphoid Neoplasms      
172  Overview of Lymphoid Neoplasms     
173  Specialized Testing in Lymphoid Neoplasms     
174  B-Precursor Neoplasms     
175   B-Lymphoblastic Leukemia    
176   Novel Genetic Subtypes of B-Lymphoblastic Leukemia    
177   BCR-ABL1-Like ALL    
178   Measurable Residual Disease Testing Strategies in ALL    
179  T-Precursor Neoplasms     
180   T-Lymphoblastic Leukemia/Lymphoma    
181   Early T-Cell Precursor Acute Lymphoblastic Leukemia    
182  Mature B-Cell Neoplasms     
183   Overview and Classification of Mature B-Cell Leukemias, Immunosecretory Lymphomas    
184   Monoclonal B-Cell Lymphocytosis    
185   Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma    
186   B-Cell Prolymphocytic Leukemia    
187   Splenic Marginal Zone Lymphoma    
188   Hairy Cell Leukemia    
189   Splenic B-Cell Leukemia, Hairy Cell Leukemia Variant    
190   Lymphoplasmacytic Lymphoma    
191   Gamma Heavy Chain Disease    
192   Monoclonal Gammopathy of Undetermined Significance    
193   Plasma Cell Myeloma    
194   Burkitt Leukemia/Lymphoma    
195   Mantle Cell Lymphoma in Blood and Bone Marrow    
196   Follicular Lymphoma in Blood and Bone Marrow    
197   Marginal Zone Lymphoma in Blood and Bone Marrow    
198   Large B-Cell Lymphomas in Blood and Bone Marrow    
199  Mature T-/NK-Cell Neoplasms     
200   Overview and Classification of Mature T-/NK-Cell Neoplasms in Blood and Bone Marrow    
201   T-Cell Prolymphocytic Leukemia    
202   T-Cell Large Granular Lymphocytic Leukemia    
203   Chronic Lymphoproliferative Disorder of NK Cells    
204   Aggressive NK-Cell Leukemia    
205   Adult T-Cell Leukemia    
206   Mycosis Fungoides/Sézary Syndrome    
207   Anaplastic Large Cell Lymphoma in Blood and Bone Marrow    
208   Other T-Cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow    
209  Hodgkin Lymphoma in Bone Marrow     
210   Hodgkin Lymphoma in Bone Marrow, Classic and Lymphocyte-Predominant Subtypes    
211 Other Neoplasms Involving Bone Marrow      
212  Langerhans Cell Histiocytosis in Bone Marrow     
213  Posttransplant Lymphoproliferative Disorders in Bone Marrow     
214  Metastatic Carcinoma and Sarcoma     
215 CAP Protocol      
216  Protocol for the Examination of Specimens from Patients with Non-Hodgkin Lymphoma/Lymphoid Neoplasms