Biopsy Interpretation: The Frozen Section

 

Description:

 

Offering expert guidance on the practical use of the frozen section in the management of clinical problems, Biopsy Interpretation: The Frozen Section, 3rd Edition, is a highly illustrated, authoritative reference on this intraoperative consultative option. New editor Dr. Nicole A. Cipriani, along with Drs. Aliya N. Husain, Jerome B. Taxy, and a team of expert contributing authors, focus not only on how to view and interpret a slide, but also when to do a frozen section. Fully up to date with extensive new content and images, this third edition emphasizes intraoperative consultation and patient management, explaining the role the general surgical pathologist can play in the treatment of patients.

 

Table of Contents:

 

1 The Frozen Section: Historical Background

HISTORY OF THE FROZEN SECTION

2 Overview and General Concepts in Intraoperative Diagnosis

INDICATIONS FOR FROZEN SECTION

TECHNICAL CONSIDERATIONS AND QUALITY ASSURANCE INDICATORS IN FROZEN SECTION

Gross Inspection and Tissue Sampling

Tissue Freezing and Sectioning

Tissue Fixation and Staining

Intraoperative Cytology

General Quality Considerations

Documentation and Reporting

Frozen Section Discrepancies

TELEPATHOLOGY

Types of Telepathology Systems

Accuracy of Telepathology

CAP Requirements for Telepathology

IMMUNOHISTOCHEMISTRY FOR FROZEN SECTION

3 Infectious Disease

INTRODUCTION

BACTERIA

Actinomyces

Mycobacteria

Sarcoidosis

FUNGUS

Dimorphic Fungus

Molds

PARASITES

Echinococcus

Cysticercosis

Ameba

CONCLUSION

PURPOSE

SCOPE

QUALITY MANAGEMENT

SAFETY PRECAUTIONS

EQUIPMENT/SUPPLIES

PROCEDURE

4 Hematolymphoid Tissue

INTRODUCTION

TOUCH IMPRINT CYTOLOGY VERSUS FROZEN SECTION

HEMATOPOIETIC VERSUS NONHEMATOPOIETIC

INTERPRETATION OF TOUCH IMPRINT CYTOLOGY

Predominance of Intermediate to Large Cells

Touch Imprint with Mostly Blasts

Touch Imprints with Mostly Monotonous Small Lymphocytes

Touch Imprint with a Mixed Cellular Pattern

SPECIAL CONSIDERATIONS

Microbiologic Culture

Thin-Needle Biopsies

Mediastinal Lesions

Pediatric Patients

Patients with a History of Solid Organ or Bone Marrow Transplantation

Patients with History of HIV

5 Bone and Soft Tissue

INTRODUCTION

CLINICAL INFORMATION

RADIOGRAPHIC IMPRESSION

EFFECTS OF DECALCIFICATION METHODS

IMPORTANT DIFFERENTIALS THROUGH CASE STUDIES

Epiphyseal Lesions

Expansile Cystic Lesions

Marrow Processes

Cartilaginous Lesions

Previous Joint Replacement and Evaluation for Infection

SUMMARY

6 Female Genital Tract

INTRODUCTION

VULVA

VAGINA

CERVIX

ENDOMETRIUM

Gross Evaluation

Histologic Evaluation

MYOMETRIUM

OVARY

Ovarian Epithelial Tumors

Ovarian Nonepithelial Tumors

Metastatic Carcinomas Involving Ovaries

Endometriosis

PRODUCTS OF CONCEPTION

7 Lung, Mediastinum, and Pleura

INTRODUCTION

THE LUNG

Gross Assessment and Processing of Lung Specimens

Gross Examination of Infectious Lungs

The Lung Frozen Section: Major Intraoperative Questions

The Lung Frozen Section—University of Chicago Experience

The Lung Frozen Section and Interpretation of Neoplastic Lesions

The Lung Frozen Section and Interpretation of Nonneoplastic Conditions Presenting as a Lung Nodule

MEDIASTINAL LYMPH NODE AND MEDIASTINAL MASS FROZEN SECTION

Mediastinal Lymph Node Frozen Section: Major Intraoperative Questions

Mediastinal Lymph Node Frozen Section and Its Interpretation

Mediastinal Mass Frozen Section and Its Interpretation

Mediastinal Frozen Section—The University of Chicago Experience

PLEURAL FROZEN SECTION AND ITS INTERPRETATION

Pleural Frozen Section—The University of Chicago Experience

8 Pediatric Frozen Section

INTRODUCTION

PEDIATRIC SOLID TUMORS

Pediatric Solid Tumors: Major Intraoperative Questions

Pediatric Solid Tumors and Frozen Section Interpretation

Specimen Handling Considerations with Pediatric Solid Tumors

Cytomorphologic Findings in Specific Pediatric Solid Tumors

HIRSCHSPRUNG DISEASE

Surgical Treatment

Hirschsprung Disease: Major Intraoperative Questions

The Frozen Section

9 Breast and Sentinel Lymph Node

BREAST FROZEN SECTION

The Breast: Major Intraoperative Questions

Other Indications (and Contraindications) for Breast Frozen Section

The Breast: Gross Specimen Handling, Frozen Section, and Its Interpretation

The Breast: Possible Emerging Technologies

SENTINEL LYMPH NODE FROZEN SECTION

The Sentinel Lymph Node: Major Intraoperative Questions

The Sentinel Lymph Node after Neoadjuvant Chemotherapy

The Sentinel Lymph Node: Gross Specimen Handling, Frozen Section, and Its Interpretation

ACKNOWLEDGMENTS

10 Genitourinary System

INTRODUCTION: GENITOURINARY FROZEN SECTION

KIDNEY: INTRODUCTION

Kidney: The Intraoperative Questions

Kidney: Frozen Section Examination

UROTHELIAL CARCINOMA: INTRODUCTION

Urothelial Carcinoma: Intraoperative Questions

Urothelial Carcinoma: Frozen Section Examination

PROSTATE CANCER: INTRODUCTION

Prostate Margins and Pelvic Lymph Nodes: Intraoperative Questions

Prostate Margins and Pelvic Lymph Nodes: Frozen Section Examination

TESTIS: INTRODUCTION

Testicular Tumor: The Intraoperative Questions

Testicular Tumor: Frozen Section Examination

PENIS AND SCROTUM

11 Head and Neck

INTRODUCTION

MUCOSAL LESIONS OF THE HEAD AND NECK

An Immediate Diagnosis on a Primary Lesion

Oropharyngeal Lesions

The Complicating Effects of Previous Treatment

The Status of a Mucosal Resection Margin

Identification of Nodal Metastasis

SALIVARY GLAND TUMORS

Specimen Handling

Benign Tumors

Malignant Tumors

SINONASAL LESIONS

CONTRAINDICATIONS FOR HEAD AND NECK FROZEN SECTION

12 Thyroid and Parathyroid

THYROID

Thyroid Intraoperative Questions

Thyroid Gross Specimen Handling

Thyroid Microscopy

Adenomatous Nodules and Follicular Neoplasms

Lymphocytic Thyroiditis

Exophytic Thyroid Nodules versus Lymph Node Metastasis versus Lateral Aberrant Thyroid

Papillary Thyroid Carcinoma

Medullary Thyroid Carcinoma

Thyroid Summary

PARATHYROID

Parathyroid Gross Specimen Handling

Parathyroid Microscopy

Parathyroid Summary

13 Gastrointestinal Tract

INTRODUCTION

ESOPHAGUS

Major Intraoperative Questions

Interpretation of the Frozen Section

STOMACH

Major Intraoperative Questions

Interpretation of the Frozen Section

SMALL BOWEL

Major Intraoperative Questions

Interpretation of the Frozen Section

APPENDIX

Major Intraoperative Questions

Interpretation of the Frozen Section

COLON AND RECTUM

Major Intraoperative Questions

Interpretation of the Frozen Section

ACKNOWLEDGMENTS

14 Liver, Extrahepatic Biliary Tree, Gallbladder, and Pancreas

LIVER

Major Intraoperative Questions

Frozen Section Interpretation

Liver Biopsy Obtained at the Time of Bariatric Surgery

Cadaveric Donor Biopsy Evaluation

GALLBLADDER AND EXTRAHEPATIC BILIARY TREE

Major Intraoperative Question

Frozen Section Interpretation

PANCREAS

Introduction

Major Intraoperative Questions

Frozen Section Interpretation

15 The Skin

INTRODUCTION

MOHS MICROGRAPHIC SURGERY

Specimen Types and Biopsy Techniques

BASAL CELL CARCINOMA

Diagnostic Pitfalls

Squamous Cell Carcinoma

Diagnostic Pitfalls

MELANOMA

Diagnostic Pitfalls

OTHER CUTANEOUS NEOPLASMS

METASTATIC MALIGNANCIES

POTENTIALLY LIFE-THREATENING INFLAMMATORY CONDITIONS

Erythema Multiforme/Toxic Epidermal Necrolysis

Infections: Viral: Herpes

Infections: Bacterial

16 Central Nervous System

INTRODUCTION

Changing Role of Intraoperative Assessments

Radiology

Type of Procedure and Reasonable Expectations

Specimen Triage

Intraoperative Assessment by Special Stains and Molecular Studies

Specific Entities and Clinical Scenarios

Infiltrating Gliomas

Low-Grade Gliomas/Neuroglial Lesions/Pediatric Gliomas

Meningioma

Other Mesenchymal or Mesenchymal-like Lesions

Ventricular/Periventricular

Sellar/Suprasellar

Embryonal Tumors Including Medulloblastoma and Atypical Teratoid Rhabdoid Tumor (AT/RT)

Spine

Other Lesions

Index

 

An aparitie	19 July 2022
Autor	Nicole A. Cipriani MD, Aliya N. Husain MD, Jerome B. Taxy MD
Editura	LWW
Format	Hardcover
ISBN	9781975170073
Limba	Engleza
Nr pag	471