Yaffe and Aranda's Neonatal and Pediatric Pharmacology: Therapeutic Principles in Practice

Description:

The premier comprehensive textbook in the field, Yaffe and Aranda’s Neonatal and Pediatric Pharmacology, Fifth Edition, provides an authoritative overview of all aspects of drug therapy in newborns, children, and adolescents. It offers evidence-based guidelines for safe, effective, and rational drug therapy, including specific recommendations for all major drug classes and diseases. Now in a vibrant two-color format, this fully revised reference is an indispensable resource for pediatricians, neonatologists, pediatric residents, and fellows in different pediatric subspecialties, including neonatal medicine and pediatric critical care.

Provides updated information on drug interactions and regulatory issues, as well as new chapters on neonatal apnea, inflammatory bowel diseases, stem cells, monoclonal antibodies, antimalarials, antimycobacterial drugs, and probiotics.

Covers pharmacology in special settings and populations, antimicrobial pharmacology, neuropharmacology, antiseizure drugs, psychopharmacology, immunopharmacology, pharmacology of biologic drugs, nutritional pharmacology, adverse drug reactions and interactions, pediatric poisoning and antidotes, medications errors in children, and more.

Offers state-of-the-art discussions on pharmacokinetics, pharmacodynamics, pharmacogenetics, pharmacogenomics, pharmacoproteomics, drug development, and clinical trials in infants and children.

Features convenient appendices containing a neonatal formulary and a pediatric formulary.

Includes eBook access to downloadable formularies and annual updates.

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Table of Contents:

1.         Cover

2.         Title Page

3.         Copyright Page

4.         Dedication

5.         Tribute to Sumner J. Yaffe, MD

6.         Foreword

7.         Preface to the Fourth Edition

8.         Preface to the Fifth Edition

9.         Contributors

10.       Contents

11.       Introduction to the Fifth Edition and Historical Highlights

12.       SECTION I: General Principles

13.       1. Clinical Trials Involving Children: History, Rationale, Regulatory Framework, and Technical Considerations

14.       2. Clinical Pharmacokinetics in Infants and Children

15.       3. Developmental Pharmacodynamics, Receptor Function, and Drug Action in Newborns and Children

16.       4. Drug Absorption, Distribution, Metabolism, Excretion, and Transporters in Newborns and Children

17.       5. Pharmacogenetics, Pharmacogenomics, and Pharmacoproteomics in Newborns and Children

18.       6. Ethics of Drug Research in Newborns and Children

19.       7. Precision Medicine and Therapeutic Drug Monitoring

20.       8. Drug Formulations for Children

21.       SECTION II: Pharmacology in Special Settings and Population: The Newborn

22.       9. Role of Placenta in Drug Metabolism and Drug Transfer

23.       10. Maternal Medications During Pregnancy and Lactation

24.       11. Principles of Neonatal Pharmacology

25.       12. Renal Function and Excretion of Drugs in the Newborn

26.       13. Neuroprotective Drugs and Perinatal Brain Injury

27.       14. Pharmacologic Agents for Neonatal Hyperbilirubinemia

28.       15. Pharmacologic Treatment of Neonatal Apnea

29.       SECTION III: Pharmacology in Special Settings and Population

30.       16. Therapeutic Applications in Pediatric Intensive Care

31.       17. Drug Therapy in the Pediatric Emergency Department

32.       18. Topical Medications

33.       19. Ophthalmologic Drugs in Infants and Children

34.       SECTION IV: Antimicrobial Pharmacology

35.       20. Penicillins, Cephalosporins, and Other β-Lactams

36.       21. Glycopeptides, Lipoglycopeptides, and Lipopeptides

37.       22. Aminoglycosides

38.       23. Macrolides, Clindamycin, and Oxazolidinones

39.       24. Fluoroquinolones

40.       25. Sulfonamides, Dihydrofolate Reductase Inhibitors, and Dapsone

41.       26. Tetracyclines, Chloramphenicol, and Metronidazole

42.       27. Antimalarials

43.       28. Anthelminthics Drugs in Children

44.       29. Antimycobacterial Drugs (Mycobacterium tuberculosis and Atypical Mycobacteria)

45.       30. Antifungal Agents

46.       31. Antivirals in Newborns and Children

47.       32. Pharmacology of Antiretroviral Drugs in Pregnant and Breastfeeding Women and Their Newborns

48.       SECTION V: Neuropharmacology

49.       33. Anticonvulsants

50.       34. Antidepressants and Mood Stabilizers

51.       35. Stimulants, ADHD Treatments, and Antipsychotics

52.       36. Analgesics and Sedatives

53.       37. Pharmacologic Management of Neonatal Abstinence Syndrome

54.       38. Local Anesthetic Agents for Regional and Superficial Anesthesia in Infants, Children, and Adolescents

55.       SECTION VI: Immunopharmacology, Allergy, and Inflammation

56.       39. Nonsteroidal Anti-Inflammatory Drugs

57.       40. Antihistamine Drugs

58.       41. Antiasthmatics

59.       42. Immunosuppressive and Immunomodulatory Drugs

60.       SECTION VII: Pharmacology of Biologic Drugs

61.       43. Microbial Therapeutics: Beyond Probiotics

62.       44. Monoclonal Antibodies

63.       45. Stem Cells

64.       46. Drugs, Lung Development, and Pulmonary Surfactant

65.       47. Childhood Vaccines

66.       SECTION VIII: Cardiorenal Drugs

67.       48. Neonatal Cardiovascular Pharmacology

68.       49. Antiarrhythmic Drugs: Disorders of Cardiac Rhythm and Pharmacologic Management

69.       50. Antihypertensive Drugs

70.       51. Diuretics

71.       SECTION IX: Gastrointestinal Pharmacology

72.       52. Gastrointestinal Drugs

73.       53. Drugs in Inflammatory Bowel Diseases

74.       SECTION X: Endocrine and Hematologic Pharmacology

75.       54. Glucocorticoids

76.       55. Insulin and Diabetes

77.       56. Growth Hormone

78.       57. Thyroid Hormones

79.       58. Hematologic Agents

80.       59. Clinical Pharmacology of Antineoplastic Drugs

81.       SECTION XI: Nutritional Pharmacology, Pharmacotoxidromes, Adverse Drug Reactions, and Interactions

82.       60. Nutrient Supplements

83.       61. Herbal Drugs in Children

84.       62. Pediatric Poisonings and Antidotes

85.       63. Adverse Drug Reactions in Newborns and Children

86.       64. Medication Errors in Children

87.       65. Drug Interactions in Newborns and Children

88.       Appendix A1: Neonatal Drug Formulary

89.       Appendix A2: Pediatric Drug Formulary

90.       Index