Wyllie’s Treatment of Epilepsy: Principles and Practice

Comprehensive, yet accessible, Wyllie’s Treatment of Epilepsy: Principles and Practice has provided a detailed and cohesive overview of seizure disorders and treatment options through six well-regarded editions. The 7th Edition remains the definitive reference in the field with extensive updates from Dr. Elaine Wyllie and her team of world-renowned editors and authors. Ideal for both clinical reference and exam preparation, this single-volume work on contemporary epileptology is an indispensable resource for neurologists, epilepsy specialists and epilepsy neurosurgeons, neurology and neurosurgery residents and fellows, and neuropsychologists.

• Features considerable new or significantly revised content reflecting the most current evidence-based treatment options.
• Offers an in-depth review of all aspects of epileptology, including neuroimaging; epilepsy surgery; antiseizure medications; principles of electroencephalography; psychosocial impact, quality of life, and comorbidities; economics of epilepsy; and more.
• Provides more than 500 CME-eligible review questions online, highlighting key concepts for the ABPN subspecialty exam and clinical practice.

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TABLE OF CONTENTS:

PART I  EPIDEMIOLOGY, GENETICS, AND MECHANISMS OF EPILEPTOGENESIS
HOWARD P. GOODKIN, ASSOCIATE EDITOR • TOBIAS LODDENKEMPER, QUESTIONS EDITOR
CHAPTER 1 Epidemiologic Aspects of Epilepsy 2
CHRISTINE LINEHAN • ANNE T. BERG
CHAPTER 2 The Natural History and Prognosis of Epilepsy 13
DING DING
CHAPTER 3 Experimental Models of Seizures and Mechanisms of Status Epilepticus and Epileptogenesis 18
TIM A. BENKE • MOLLY M. HUNTSMAN • AMY BROOKS-KAYAL
CHAPTER 4 Genetic Aspects of the Epilepsies 29
ERIKA TAKLE AXEEN • ANNAPURNA PODURI
CHAPTER 5 Pictorial Atlas of Epilepsy Substrates 36
AJAY GUPTA • RICHARD A. PRAYSON

PART II  BASIC PRINCIPLES OF ELECTROENCEPHALOGRAPHY
TOBIAS LODDENKEMPER, ASSOCIATE EDITOR, QUESTIONS EDITOR
CHAPTER 6 Neurophysiologic Basis of the Electroencephalogram 53
ERWIN-JOSEF SPECKMANN • CHRISTIAN E. ELGER • ALI GORJI
CHAPTER 7 Localization and Field Determination in Electroencephalography 68
RICHARD C. BURGESS
CHAPTER 8 Electroencephalographic Atlas of Epileptiform Abnormalities 90
SOHEYL NOACHTAR • ELAINE WYLLIE
CHAPTER 9 Quality Standards and Logistics of Establishing an Epilepsy Monitoring Unit 130
DEEPAK K. LACHHWANI

PART III  EPILEPTIC SEIZURES AND SYNDROMES
SECTION A ¦ ELECTROCLINICAL SYNDROMES
TOBIAS LODDENKEMPER, ASSOCIATE EDITOR, QUESTIONS EDITOR
CHAPTER 10 The Revised Definition and Classification of Seizures and Epilepsies 137
ROBERT S. FISHER • TOBIAS LODDENKEMPER
CHAPTER 11 Seizure Types and Semiology 145
CLAUDE STERIADE • PATRICK CHAUVEL • PRAKASH KOTAGAL
CHAPTER 12 Epileptic Auras 161
NORMAN K. SO
CHAPTER 13 Focal Epileptogenic Networks 172
DILEEP NAIR • JUAN C. BULACIO • PATRICK CHAUVEL
CHAPTER 14 Electroclinical Syndromes of Infancy 183
ELIA M. PESTANA KNIGHTCHAPTER 15 Electroclinical Syndromes in Childhood and Adolescence 200
KATHERINE NICKELS • RENÉE SHELLHAAS • ELAINE WYLLIE • ELAINE C. WIRRELL
CHAPTER 16 Continuous Spike-and-Wave During Sleep, Including Landau–Kleffner Syndrome 220
IVÁN SÁNCHEZ FERNÁNDEZ • TOBIAS LODDENKEMPER
CHAPTER 17 Epilepsy with Reflex Seizures 230
DOROTHÉE G. A. KASTELEIJN-NOLST TRENITÉ
SECTION B ¦ SPECIFIC ETIOLOGIES
HOWARD P . GOODKIN, ASSOCIATE EDITOR • TOBIAS LODDENKEMPER, QUESTIONS EDITOR
CHAPTER 18 Hippocampal Sclerosis and Dual Pathology 245
OLESYA GRINENKO • INGMAR BLÜMCKE • IMAD M. NAJM
CHAPTER 19 Malformations of Cortical Development and Epilepsy 252
RICHARD J. LEVENTER • RENZO GUERRINI
CHAPTER 20 New Neuropathologic Concepts in Focal Cortical Dysplasias 263
HARVEY B. SARNAT
CHAPTER 21 Brain Tumors and Epilepsy 272
LARA JEHI • INGMAR BLÜMCKE
CHAPTER 22 Posttraumatic Epilepsy 284
JAY R. GAVVALA • STEPHAN U. SCHUELE
CHAPTER 23 Epilepsy in the Setting of Cerebrovascular Disease 298
CHARLES ÁKOS SZABÓ • STEPHEN HANTUS • BERND POHLMANN-EDEN
CHAPTER 24 Epilepsy in the Setting of Neurocutaneous Syndromes 306
PHILLIP L. PEARL • AJAY GUPTA
CHAPTER 25 Epilepsy in the Setting of Inherited Metabolic and Mitochondrial Disorders 317
SUMIT PARIKH • DOUGLAS R. NORDLI JR • DARRYL C. DE VIVO
CHAPTER 26 Progressive Myoclonic Epilepsies 344
BERND A. NEUBAUER • ANDREAS HAHN
CHAPTER 27 Central Nervous System Infections and Epilepsy 359
GAGANDEEP SINGH • J. M. K. MURTHY
CHAPTER 28 Autoimmune Epilepsy and Encephalitis 369
CLAUDE STERIADE • NICOLAS GASPARD • AHSAN N. V. MOOSA
CHAPTER 29 Rasmussen Encephalitis 380
CHRISTIAN G. BIEN • FRANÇOIS DUBEAU
SECTION C ¦ DIAGNOSIS AND TREATMENT OF SEIZURES IN SPECIAL CLINICAL SETTINGS
HOWARD P . GOODKIN, ASSOCIATE EDITOR • TOBIAS LODDENKEMPER, QUESTIONS EDITOR
CHAPTER 30 Febrile Seizures and Genetic Epilepsy with Febrile Seizures Plus (GEFS+) 392
SYNDI A. SEINFELD • MICHAEL DUCHOWNY
CHAPTER 31 Approach to the Patient with a First Seizure 398
EMILY L. JOHNSON • GREGORY K. BERGEY
CHAPTER 32 Neonatal Seizures and EEG 404
COURTNEY J. WUSTHOFF • ELI M. MIZRAHI • ROBERT R. CLANCY • ELIA M. PESTANA KNIGHT
CHAPTER 33 Epilepsy in the Elderly 421
ANDREY S. STOJIC • CAMILO I. GARCÍA GRACIA • LARA JEHI • ILO E. LEPPIK
CHAPTER 34 Seizures Associated with Nonneurologic Medical Conditions 430
STEPHAN EISENSCHENK • SWAPNA SURABHI • YUE WANGCHAPTER 35 Sleep and Epilepsy 439
NANCY FOLDVARY-SCHAEFER • SILVIA NEME-MERCANTE
CHAPTER 36 Status Epilepticus 449
VINEET PUNIA • HOWARD P . GOODKIN
CHAPTER 37 Electroencephalography and Seizures in the Intensive Care Setting 464
STEPHEN HANTUS • NICHOLAS S. ABEND
SECTION D ¦ DIFFERENTIAL DIAGNOSIS OF EPILEPSY
LARA JEHI, ASSOCIATE EDITOR, QUESTIONS EDITOR
CHAPTER 38 Psychogenic Nonepileptic Seizures 473
W. CURT LAFRANCE JR • HAMADA HAMID ALTALIB • BECKY BIKAT TILAHUN
CHAPTER 39 Other Nonepileptic Paroxysmal Disorders 483
ELIA M. PESTANA KNIGHT • ADRIANA S. TANNER

PART IV  ANTISEIZURE MEDICATIONS
SECTION A ¦ GENERAL PRINCIPLES OF ANTISEIZURE MEDICATION THERAPY
BARRY E. GIDAL, ASSOCIATE EDITOR
CHAPTER 40 Antiseizure Medication Development and Experimental Models 503
MELISSA BARKER-HALISKI • H. STEVE WHITE
CHAPTER 41 Mechanisms of Action of Antiseizure Medication 509
MICHAEL A. ROGAWSKI • JOSÉ E. CAVAZOS
CHAPTER 42 Pharmacokinetics and Drug Interactions 520
GAIL D. ANDERSON
CHAPTER 43 Initiation and Discontinuation of Antiseizure Medications 531
VARDA GROSS-TSUR • RUTH C. SHINNAR • SHLOMO SHINNAR
CHAPTER 44 Treatment of Acute and Repetitive Seizures 544
IVÁN SÁNCHEZ FERNÁNDEZ • TOBIAS LODDENKEMPER
CHAPTER 45 Hormones, Catamenial Epilepsy, Sexual Function, and Reproductive and Bone Health in Epilepsy 553
NITIN K. SETHI • CYNTHIA L. HARDEN
CHAPTER 46 Treatment of Epilepsy During Pregnancy 561
PAGE B. PENNELL • P . EMANUELA VOINESCU
CHAPTER 47 Individual Approach to Laboratory Monitoring of Antiseizure Medication 569
SVEIN I. JOHANNESSEN • PHILIP N. PATSALOS
SECTION B ¦ SPECIFIC ANTIEPILEPTIC MEDICATIONS AND TREATMENTS
BARRY E. GIDAL, ASSOCIATE EDITOR
CHAPTER 48 Benzodiazepines 575
L. JOHN GREENFIELD JR • KINSHUK SAHAYA • SANG-HUN LEE
CHAPTER 49 Carbamazepine, Oxcarbazepine, and Eslicarbazepine 599
CARLOS A. M. GUERREIRO • MARILISA M. GUERREIRO • SCOTT MINTZER
CHAPTER 50 Ethosuximide 610
ANDRES M. KANNER • RAMSES RIBOT
CHAPTER 51 Felbamate 623
MONICA B. DHAKAR • EDWARD FAUGHT
CHAPTER 52 Gabapentin and Pregabalin 629
PIERO PERUCCACHAPTER 53 Lacosamide 641
ROBERT T. WECHSLER • RAJ D. SHETH
CHAPTER 54 Lamotrigine 646
JOHN M. STERN • BARRY E. GIDAL
CHAPTER 55 Levetiracetam and Brivaracetam 654
ERIN M. OKAZAKI • JOSEPH I. SIRVEN • KATHERINE H. NOE • MATTHEW T. HOERTH • PAVEL KLEIN
CHAPTER 56 Perampanel 663
GREGORY L. KRAUSS • BARRY E. GIDAL
CHAPTER 57 Phenobarbital and Primidone 669
JACQUELYN L. BAINBRIDGE • MARK C. SPITZ • PEI SHIEEN WONG • SARAH N. FISCHER
CHAPTER 58 Phenytoin and Fosphenytoin 678
JEANNINE M. CONWAY
CHAPTER 59 Rufinamide 693
GREGORY L. KRAUSS • RAMA MAGANTI
CHAPTER 60 Topiramate 701
WILLIAM E. ROSENFELD
CHAPTER 61 Valproate 715
ANGELA K. BIRNBAUM • SUSAN E. MARINO
CHAPTER 62 Vigabatrin 724
KELLY G. KNUPP • ELIZABETH A. THIELE
CHAPTER 63 Zonisamide 731
TIMOTHY E. WELTY
CHAPTER 64 Adrenocorticotropin and Steroids 738
CRISTINA GO • O. CARTER SNEAD III
CHAPTER 65 Cannabidiol 747
JERZY P . SZAFLARSKI • ORRIN DEVINSKY
CHAPTER 66 Antiseizure Medications in Clinical Development 752
DEANA M. GAZZOLA • NORMAN DELANTY • JACQUELINE A. FRENCH
CHAPTER 67 Less Commonly Used Antiseizure Medications 763
ROBERT J. KOTLOSKI • ROBERT T. WECHSLER • BASIM M. UTHMAN • BAILEY G. SALIMES
CHAPTER 68 Dietary Therapies for Epilepsy 772
ERIC H. W. KOSSOFF

PART V  EPILEPSY SURGERY
SECTION A ¦ IDENTIFYING SURGICAL CANDIDATES AND DEFINING THE EPILEPTOGENIC NETWORK
LARA JEHI, ASSOCIATE EDITOR, QUESTIONS EDITOR
CHAPTER 69 Issues of Medical Intractability for Surgical Candidacy 780
SAMUEL WIEBE • CHURL-SU KWON • NATHALIE JETTÉ
CHAPTER 70 Magnetic Resonance Imaging in the Evaluation for Epilepsy Surgery 788
AHSAN N. V. MOOSA • PAUL M. RUGGIERI
CHAPTER 71 Video–EEG Monitoring in the Presurgical Evaluation 806
JEFFREY W. BRITTON • DAVID B. BURKHOLDER
CHAPTER 72 Nuclear Imaging (PET, SPECT) 820
WILLIAM DAVIS GAILLARDCHAPTER 73 Magnetoencephalography 831
RICHARD C. BURGESS • JOHN C. MOSHER
CHAPTER 74 MRI Postprocessing Techniques and Clinical Applications 849
ZHONG IRENE WANG • STEPHEN E. JONES • ANDREA BERNASCONI
CHAPTER 75 MRI Connectivity Analyses: Imaging Networks in Epilepsy 860
EZEQUIEL GLEICHGERRCHT • LEONARDO BONILHA
CHAPTER 76 Diffusion Tensor Imaging (DTI) and EEG-Correlated fMRI 867
BEATE DIEHL • LOUIS LEMIEUX
CHAPTER 77 Mapping Epileptic Networks with Intracranial Electrodes 881
JUAN C. BULACIO • JORGE A. GONZÁLEZ-MARTÍNEZ
SECTION B ¦ MAPPING ELOQUENT CORTEX
LARA JEHI, ASSOCIATE EDITOR, QUESTIONS EDITOR
CHAPTER 78 Functional Mapping with Neurophysiologic Techniques 891
RIKI MATSUMOTO • SASHA DIONISIO • MARTIN STAUDT • JUAN C. BULACIO • DILEEP NAIR
CHAPTER 79 Language and Memory Mapping 905
JEFFREY R. BINDER • CHAD CARLSON
SECTION C ¦ EPILEPSY SURGERY IN SPECIFIC CLINICAL SETTINGS
TOBIAS LODDENKEMPER, ASSOCIATE EDITOR, QUESTIONS EDITOR
CHAPTER 80 Surgery for Medically Refractory Temporal Lobe Epilepsy 917
ALVIN Y. CHAN • WILLIAM E. BINGAMAN • IMAD M. NAJM • SUMEET VADERA
CHAPTER 81 Surgery for Focal Cortical Dysplasias (FCDs) 924
ANDRE PALMINI • IMAD M. NAJM • WILLIAM E. BINGAMAN
CHAPTER 82 Hemispherectomy: Indications, Procedures, and Outcome 934
AHSAN N. V. MOOSA • JORGE A. GONZÁLEZ-MARTÍNEZ • WILLIAM E. BINGAMAN
CHAPTER 83 Surgical Approach in Multilesional or Multilobar Epilepsies 945
ELIA M. PESTANA KNIGHT • ELAINE WYLLIE
CHAPTER 84 Surgical Approach in Nonlesional Cases 954
DEEPAK K. LACHHWANI • JORGE A. GONZÁLEZ-MARTÍNEZ
CHAPTER 85 Hypothalamic Hamartoma 964
JOHN F. KERRIGAN • ANGUS A. WILFONG
CHAPTER 86 Corpus Callosotomy and Multiple Subpial Transection 982
MICHAEL C. SMITH • RICHARD W. BYRNE • ANDRES M. KANNER
CHAPTER 87 Epilepsy Surgery: Special Considerations in Children 991
AHSAN N. V. MOOSA • ELAINE WYLLIE
CHAPTER 88 Ablative Treatments for Epilepsy 1001
PATRICK J. KARAS • A. BASIT KHAN • DANIEL J. CURRY
CHAPTER 89 Outcome and Complications of Epilepsy Surgery 1012
ROBERT A. MCGOVERN • LARA JEHI • JORGE A. GONZÁLEZ-MARTÍNEZ • WILLIAM E. BINGAMAN
CHAPTER 90 Vagus Nerve Stimulation Therapy 1027
JAMES W. WHELESS • ANDREW J. GIENAPP • BASANAGOUD MUDIGOUDAR
CHAPTER 91 Responsive Neurostimulation Therapy: RNS System 1043
CHRISTIANNE N. HECK • WILLIAM O. TATUM
CHAPTER 92 Deep Brain Stimulation Epilepsy 1048
ROBERT S. FISHERPART VI ¦ PSYCHOSOCIAL IMPACT, QUALITY OF LIFE, AND COMORBIDITIES, AND ECONOMICS OF EPILEPSY
LARA JEHI, ASSOCIATE EDITOR, QUESTIONS EDITOR
CHAPTER 93 Cognitive Effects of Epilepsy and Its Treatments 1058
KIMFORD J. MEADOR
CHAPTER 94 Psychiatric Comorbidity of Epilepsy 1064
BETH A. LEEMAN-MARKOWSKI • STEVEN C. SCHACHTER
CHAPTER 95 Sudden Unexpected Death in Epilepsy (SUDEP) 1078
DAVID P . HARRIS • LISA M. BATEMAN
CHAPTER 96 Driving and Social Issues in Epilepsy 1085
AMY Z. CREPEAU • JOSEPH F. DRAZKOWSKI
CHAPTER 97 Ambulatory Seizure Monitoring and Acute Seizure Detection 1092
STEVEN C. SCHACHTER
CHAPTER 98 Quality of Life with Epilepsy 1095
TATIANA FALCONE • JESSICA R. FESLER
APPENDIX ¦ ASSOCIATE EDITOR: BARRY E. GIDAL
Indications for Antiseizure Medications Sanctioned by the U.S. Food and Drug Administration 1101
BRITANY WALLS
Index 1103