The Pathology of Cardiac Transplantation: A clinical and pathological perspective

This is the first book to focus entirely on the role of pathology in cardiac transplantation, linked to the clinical perspective through clinical–pathological correlation, multidisciplinary team working, and collaborative research. It provides a scientific framework with up-to-date pathological protocols and classification schemes and guides the reader through the chronological phases of the transplant process in a step-by-step approach. Topics include end-stage heart failure with pathologies encountered in the native heart, current issues surrounding donor selection, the multiple faces of rejection pathology correlated with clinical management and immunology, other post-transplant complications, details of pediatric and combined heart/other organ transplantation, and a useful practical appendix. Many high-quality images and illustrative cases are presented, along with learning points and ample references.

Transplantation medicine today is continuously changing as collaborative research into novel diagnostic techniques and immunosuppressive therapies translates into improved recipient management and survival. This book is aimed at practicing transplant pathologists and specialist trainees. It will also appeal to general pathologists and to physicians and surgeons involved in cardiac transplantation who need to understand the role of pathology in the clinical management of transplant recipients.

Table of contents (25 chapters)

• Cardiac Transplantation and the Contribution of Pathology

Pages 3-10

Burke, Margaret, MB, FRCPath (et al.)

• Advanced End-Stage Heart Failure: Epidemiology and Management

Pages 13-20

Parissis, John (et al.)

• Mechanical Circulatory Support in End-Stage Heart Failure: Bridge to Transplantation and Destination Therapy

Pages 21-32

Stepanenko, Alexander, MD (et al.)

• Clinical Indications for Heart Transplantation

Pages 33-40

Tona, Francesco, MD, PhD (et al.)

• Pathologies Encountered in Explanted Native Hearts

Pages 41-99

Leone, Ornella (et al.)

• Pretransplant Endomyocardial Biopsy: When and Why

Pages 101-112

Veinot, John P., MD, FRCPC

• Donor Selection Criteria: Clinical and Pathological Insights

Pages 115-135

Leone, Ornella (et al.)

• Donor Organ Harvesting and Preservation

Pages 137-145

Bejko, Jonida (et al.)

• Perioperative Myocardial Damage to the Graft

Pages 147-152

Angelini, Annalisa (et al.)

• Graft Failure/Dysfunction: Clinical Issues and Role of Endomyocardial Biopsy

Pages 155-169

Potena, Luciano (et al.)

• Clinical Management of Transplant Recipients

Pages 171-184

Masetti, Marco, PhD (et al.)

• Practical Immunology for Pathologists

Pages 185-198

Smith, John D., FRCPath (et al.)

• Pathology of Acute Cellular Rejection

Pages 199-217

Neil, Desley A. H., MD (et al.)

• Pathology of Antibody-Mediated Rejection

Pages 219-242

Rotman, Samuel (et al.)

• “Mixed” Rejection in Heart Transplantation

Pages 243-250

Miller, Dylan V., MD (et al.)

• Pathological Non-rejection Findings in the Endomyocardial Biopsy

Pages 251-263

Doran, Helen (et al.)

• Noninvasive Tools for Monitoring Acute Cardiac Allograft Rejection: State of the Art

Pages 265-277

Parent, Marie-Claude, MD, MSc, FRCPC (et al.)

• Cardiac Allograft Vasculopathy

Pages 279-305

Fedrigo, Marny (et al.)

• Infections

Pages 309-327

Lebeaux, David (et al.)

• Malignancies After Heart Transplantation

Pages 329-352

Agostini, Valentina, MD (et al.)

Chronic Kidney Disease After Heart Transplantation: Risk Factors, Clinics, and Histopathology

Pages 353-364

Magnani, Gaia (et al.)

• Pathology of Pediatric Heart Transplantation

Pages 367-377

Huyen, Jean-Paul Duong, MD, PhD (et al.)

• Combined Heart Transplants

Pages 379-391

Goddard, Martin

• The Autopsy in Heart Transplantation

Pages 393-417

Angelini, Annalisa (et al.)

• Examination of Native Hearts with Implantable Mechanical Circulatory Support Systems

Pages 419-425

Aumayr, Klaus, MD (et al.)