Textbook of Pancreatic Cancer

Description:

This textbook provides a practically applicable resource for understanding the surgical oncology management of pancreatic cancer. It discusses relevant aspects of anatomy and pathophysiology along with the latest diagnostic techniques. Insightful descriptions are then provided detailing how to perform critical surgical procedures when treating these patients.  Relevant perioperative management strategies and emerging themes in cancer biology critical to understanding and treating the disease are also described. The need for cross-discipline collaboration to facilitate and enhance innovation within the discipline is reinforced throughout the text. Each chapter presents the relevant current clinical standards along with areas of controversy in both research and clinical practice within “pearls and pitfalls” sections. Textbook of Pancreatic Cancer: Principles and Practice of Surgical Oncology is a detailed work covering the basic material important to trainees as well as advanced curriculum for established specialists in the field from a multi-disciplinary perspective. Therefore, it is crucial resource for all practicing and trainee professionals who encounter these patients in their day-to-day clinical practice.

Table of contents:

Cover

Front Matter

Part I. Pancreatic Cancer Disease Burden

1. Risk Factors for Pancreatic Cancer

2. Epidemiology of Pancreatic Cancer

3. Hereditary Syndromes and Pancreatic Cancer

4. Familial Pancreatic Cancer

Part II. Education, Training and Quality of Care

5. Education and Training in Pancreatic Surgery

6. Quality of Care Indicators in Pancreatic Cancer

7. The Quantity and Quality of Surgical Trials in Pancreatic Cancer

8. Mandatory Reporting Measurements in Trials for Potentially Resectable Pancreatic Cancer

9. Regionalization to Improve Outcomes in Pancreatic Surgery

10. Oncopolitics in Pancreatic Cancer

Part III. The Pancreas

11. Anatomy and Embryology of the Pancreatic Gland

12. Vascular Supply: Important Arterial and Venous Variants

13. The Lymphatic System and Lymph Nodes of the Pancreas

Part IV. Understanding Disease Biology

14. The Hallmarks of Pancreatic Cancer

15. Pathobiology of Precursors to Pancreatic Cancer

16. Cancer Cell Metabolism in Pancreatic Ductal Adenocarcinoma

17. The Cachexia Syndrome in Pancreatic Cancer

18. Role of Stroma in Pancreatic Cancer

19. Role of the Microbiome in Pancreatic Cancer

20. Immuno-Oncology in Pancreatic Cancer

21. Molecular Subtyping of Pancreatic Cancer

22. The Role of Epigenetics in Pancreatic Ductal Adenocarcinoma

Part V. Diagnosis, Imaging and Staging

23. Early Diagnosis of Sporadic Pancreatic Cancer

24. Clinical Presentation and Symptoms in Pancreatic Cancer

25. TNM Staging for Pancreatic Adenocarcinoma

26. Computed Tomography for Diagnosis and Staging in Pancreatic Cancer

27. MR/MRCP for Diagnosis and Staging

28. EUS Evaluation of Pancreatic Cystic Lesions

29. Imaging After Neoadjuvant Therapy

30. The Role of CA 19-9 in Pancreatic Adenocarcinoma

31. Biomarkers in Pancreatic Cancer

32. Difficult Diagnosis and Differentials to a Solid Pancreatic Tumour

33. The Multidisciplinary Team Conference

34. Gross Evaluation and Histopathology

35. Rare Tumors of the Pancreas

36. PET in Pancreatic Cancer

Part VI. Perioperative Care

37. Prehabilitation for Pancreatic Cancer Surgery

38. Enhanced Recovery Principles in Pancreatic Cancer Surgery

39. The Elderly Patient with Pancreatic Cancer: Trends and Medical Oncology

40. Surgery/Interventions in the Elderly Patient with Pancreatic Cancer

41. Preoperative Management of Jaundice

42. Nutritional Support and Therapy Before and After Pancreatic Surgery

43. Management of Pancreatic Exocrine Insufficiency

44. Chemotherapy for Advanced Pancreatic Cancer: Available Drugs, Mechanisms and Toxicity

45. Neoadjuvant Therapy in Upfront Resectable Pancreatic Cancer

46. Neoadjuvant and Adjuvant Radiotherapy in Operable Pancreatic Cancer

47. Preoperative Therapy in Patients with Borderline Resectable and Locally Advanced Pancreatic Cancer

48. The Evolution of Adjuvant Trials in Pancreatic Cancer

Part VII. Surgery

49. IPMN as a Premalignant Condition

50. Pancreatic Cystic Lesions and Risk of Cancer

51. EUS and Solid Pancreatic Lesions

52. The Role of Laparoscopic Staging in Pancreatic Cancer

53. Standard Pancreatoduodenectomy for Resectable Pancreatic Cancer

54. Pancreatoduodenectomy with Portal Vein Resection

55. The Artery-First Approach in Pancreatic Cancer Surgery

56. Pancreatic Surgery with Arterial Resections

57. Laparoscopic Pancreatoduodenectomy for Pancreatic Cancer

58. Robotic Surgery for Pancreatic Cancer

59. Robotic-Assisted Pancreatic Surgery for Pancreatic Cancer: Technical Aspects

60. The Role of Surgery in Oligo-Metastatic Pancreatic Cancer

61. Total Pancreatectomy

62. Open Distal Pancreatectomy for Pancreatic Cancer

63. Laparoscopic Distal Pancreatectomy

64. Distal Pancreatectomy with Celiac Artery Resection (DP-CAR)

65. Evolution of Surgery for Pancreatic Cancer and Future Directions

Part VIII. Complications After Pancreatic Surgery

66. Chyle Leak After Pancreatic Surgery

67. Post-op Pancreatic Hemorrhage

68. Post-Operative Pancreatic Fistula After Pancreatic Surgery

69. Delayed Gastric Emptying After Pancreatic Surgery

70. Uncommon and Rare Complications After Pancreatic Surgery

Part IX. Outcomes

71. Quality Metrics and Performance Evaluation in Pancreatic Surgery

72. Surveillance After Surgery for Pancreatic Cancer

73. Survival After Resection for Pancreatic Cancer

74. Patterns of Recurrence After Surgery for Pancreatic Cancer

75. Patient-Reported Outcomes and Quality of Life in Pancreatic Cancer

Part X. Palliation and End of Life Issues

76. Palliative Care in Pancreatic Cancer

77. Pain in Pancreatic Cancer: Mechanisms and Management

78. Jaundice in Pancreatic Cancer

79. Palliative Endoscopic Therapy in Pancreatic Cancer

80. Surgical Palliation for Inoperable Pancreatic Cancer

81. Definitive or Palliative Radiotherapy for Unresectable Pancreatic Cancer

82. Role of Ablation Technologies in Locally Advanced Pancreatic Cancer

83. Sonoporation to Enhance Drug Delivery in Metastatic Pancreatic Cancer

84. Best Supportive Care in Advanced Pancreatic Cancer

Correction to: Palliative Endoscopic Therapy in Pancreatic Cancer

Back Matter