Robbins & Cotran Pathologic Basis of Disease (Robbins Pathology)

 

Description:

Readable and highly illustrated, Robbins and Cotran Pathologic Basis of Disease, 10th Edition presents an in-depth, state-of-the-art overview of human diseases and their cellular and molecular basis. This best-selling text delivers the latest, most essential pathology knowledge in a readable, interesting manner, ensuring optimal understanding of the latest basic science and clinical content. More than 1,000 high-quality photographs and full-color illustrations highlight new information in molecular biology, disease classifications, new drugs and drug therapies, and much more. This superb learning package also includes an enhanced eBook with a full complement of ancillary content on Student Consult.

Provides uniquely authoritative and readable coverage, ideal for USMLE or specialty board preparation, as well as for coursework.

Covers the hot topics you need to know about, including novel therapies for hepatitis C, classification of lymphomas, unfolded protein response, non-apoptotic pathways of cell death, coronavirus infections, liquid biopsy for cancer detection, regulation of iron absorption, clonal hematopoiesis and atherosclerosis, thrombotic microangiopathies, heparin-induced thrombocytopenias, inflammatory myopathies, genetic tools for treatment of cystic fibrosis, and many more. 

Uses an outstanding full-color, user-friendly design to simplify your study and quickly direct you to the information you need to know, with learning features such as boldface overviews at the beginning of each section, key concepts boxes, suggested readings, schematic diagrams that illustrate complex concepts, and new gross and microscopic figures for clarity of morphology.

Brings you up to date with the latest information in molecular and genetic testing, mechanisms of disease, personalized medicine and its impact on treatment of human diseases, the role of microbiome and metabolome in non-communicable diseases, and much more.

Provides access to a wealth of interactive ancillaries online: pathology case studies, videos, self-assessment questions, Targeted Therapy boxes that discuss drug therapy for specific diseases, interactive cases, and more.

Evolve Instructor site with an image and test bank is available to instructors through their Elsevier sales rep or via request at https://evolve.elsevier.com.

 

 

Table of Contents:

 

Chapter 1 The Cell as a Unit of Health and Disease

The Genome

Cellular Housekeeping

Cellular Metabolism and Mitochondrial Function

Cellular Activation

Growth Factors and Receptors

Extracellular Matrix

Maintaining Cell Populations

Suggested Readings

 

Chapter 2 Cell Injury, Cell Death, and Adaptations

Introduction to Pathology

Overview of Cellular Responses to Stress and Noxious Stimuli

Reversible Cell Injury

Cell Death

Mechanisms of Cell Injury

Clinicopathologic Correlations: Selected Examples of Cell Injury and DEATH

Adaptations of Cellular Growth and Differentiation

Intracellular Accumulations

Pathologic Calcification

Cellular Aging

Suggested Readings

 

Chapter 3 Inflammation and Repair

Overview of Inflammation: Definitions and General Features

Acute Inflammation

Chronic Inflammation

Systemic Effects of Inflammation

Tissue Repair

Suggested Readings

 

Chapter 4 Hemodynamic Disorders, Thromboembolic Disease, and Shock

Edema and Effusions

Hyperemia and Congestion

Hemostasis, Hemorrhagic Disorders, and Thrombosis

Embolism

Infarction

Shock

Suggested Readings

 

Chapter 5 Genetic Disorders

Genes and Human Diseases

Mendelian Disorders

Complex Multigenic Disorders

Chromosomal Disorders

Single-Gene Disorders With Nonclassic Inheritance

Molecular Genetic Diagnosis

Acknowledgment

Suggested Readings

 

Chapter 6 Diseases of the Immune System

The Normal Immune Response

Hypersensitivity: Immunologically Mediated Tissue Injury

Autoimmune Diseases

Rejection of Tissue Transplants

Immunodeficiency Diseases

Amyloidosis

Suggested Readings

 

Chapter 7 Neoplasia

Nomenclature

Characteristics of Benign and Malignant Neoplasms

Epidemiology of Cancer

Molecular Basis of Cancer: Role of Genetic and Epigenetic Alterations

Carcinogenic Agents and Their Cellular Interactions

Clinical Aspects of Neoplasia

Suggested Readings

 

Chapter 8 Infectious Diseases

 

General Principles of Microbial Pathogenesis

Viral Infections

Bacterial Infections

Fungal Infections

Parasitic Infections

Sexually Transmitted Infections

Emerging Infectious Diseases

Special Techniques for Diagnosing Infectious Agents

Suggested Readings

 

Chapter 9 Environmental and Nutritional Diseases

Health Effects of Climate Change

Toxicity of Chemical and Physical Agents

Environmental Pollution

Occupational Health Risks: Industrial and Agricultural Exposures

Effects of Alcohol

Injury by Therapeutic Drugs and Drugs of Abuse

Injury by Physical Agents

Nutritional Diseases

Suggested Readings

 

Chapter 10 Diseases of Infancy and Childhood

Congenital Anomalies

Prematurity and Fetal Growth Restriction

Perinatal Infections

Fetal Hydrops

Inborn Errors of Metabolism and Other Genetic Disorders

Sudden Infant Death Syndrome

Tumors and Tumorlike Lesions of Infancy and Childhood

Suggested Readings

 

Chapter 11 Blood Vessels

Vascular Structure and Function

Vascular Anomalies

Vascular Wall Response to Injury

Hypertensive Vascular Disease

Arteriosclerosis

Atherosclerosis

Aneurysms and Dissection

Vasculitis

Disorders of Blood Vessel Hyperreactivity

Veins and Lymphatics

Vascular Tumors

Pathology of Vascular Intervention

Suggested Readings

 

Chapter 12 The Heart

Cardiac Structure and Specializations

Overview of Cardiac Pathophysiology

Heart Failure

Cardiac Development

Congenital Heart Disease

Ischemic Heart Disease

Arrhythmias

Hypertensive Heart Disease

Valvular Heart Disease

Cardiomyopathies

Pericardial Disease

Tumors of the Heart

Cardiac Transplantation

Cardiac Devices

Suggested Readings

 

Chapter 13 Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus

Normal Hematopoiesis

Disorders of White Cells

Spleen

Thymus

Suggested Readings

 

Chapter 14 Red Blood Cell and Bleeding Disorders

Anemias

Polycythemia

Bleeding Disorders: Hemorrhagic Diatheses

Suggested Readings

 

Chapter 15 The Lung

Congenital Anomalies

Atelectasis (Collapse)

Pulmonary Edema

Acute Lung Injury and Acute Respiratory Distress Syndrome (Diffuse Alveolar Damage)

Obstructive and Restrictive Lung Diseases

Obstructive Lung Diseases

Chronic Diffuse Interstitial (Restrictive) Diseases

Diseases of Vascular Origin

Pulmonary Infections

Lung Transplantation

Tumors

Pleura

Suggested Readings

 

Chapter 16 Head and Neck

Oral Cavity

Upper Airways

Ears

Neck

Salivary Glands

Suggested Readings

 

Chapter 17 The Gastrointestinal Tract

Congenital Abnormalities

Esophagus

Stomach

Small Intestine and Colon

Peritoneal Cavity

Suggested Readings

 

Chapter 18 Liver and Gallbladder

The Liver and Bile Ducts

Gallbladder

Suggested Readings

 

Chapter 19 The Pancreas

Congenital Anomalies

Pancreatitis

Nonneoplastic Cysts

Neoplasms

Suggested Readings

 

Chapter 20 The Kidney

Clinical Manifestations of Renal Diseases

Glomerular Diseases

Tubular and Interstitial Diseases

Vascular Diseases

Congenital and Developmental Anomalies

Cystic Diseases of the Kidney

Urinary Tract Obstruction (Obstructive Uropathy)

Urolithiasis (Renal Calculi, Stones)

Neoplasms of the Kidney

Suggested Readings

 

Chapter 21 The Lower Urinary Tract and Male Genital System

The Lower Urinary Tract

The Male Genital Tract

Suggested Readings

 

Chapter 22 The Female Genital Tract

Vulva

Vagina

Cervix

Body of Uterus and Endometrium

Ovaries

Gestational and Placental Disorders

Suggested Readings

 

Chapter 23 The Breast

Disorders of Development

Clinical Presentations of Breast Disease

Inflammatory Disorders

Benign Epithelial Lesions

Carcinoma of the Breast

Stromal Tumors

Other Malignant Tumors of the Breast

Suggested Readings

 

Chapter 24 The Endocrine System

Pituitary Gland

Thyroid Gland

Parathyroid Glands

The Endocrine Pancreas

Adrenal Glands

Multiple Endocrine Neoplasia Syndromes

Pineal Gland

Suggested Readings

 

Chapter 25 The Skin

The Skin: More Than a Mechanical Barrier

Disorders of Pigmentation and Melanocytes

Benign Epithelial Tumors

Adnexal (Appendage) Tumors

Premalignant and Malignant Epidermal Tumors

Tumors of the Dermis

Tumors of Cellular Migrants to the Skin

Disorders of Epidermal Maturation

Acute Inflammatory Dermatoses

Chronic Inflammatory Dermatoses

Blistering (Bullous) Diseases

Disorders of Epidermal Appendages

Panniculitis

Infection

Suggested Readings

 

Chapter 26 Bones, Joints, and Soft Tissue Tumors

Bone

Joints

Soft Tissue Tumors

Suggested Readings

 

Chapter 27 Peripheral Nerves and Skeletal Muscles

Diseases of Peripheral Nerves

Diseases of the Neuromuscular Junction

Diseases of Skeletal Muscle

Peripheral Nerve Sheath Tumors

Suggested Readings

 

Chapter 28 The Central Nervous System

Cellular Pathology of the Central Nervous System

Cerebral Edema, Hydrocephalus, Raised Intracranial Pressure, and Herniation

Malformations and Developmental Disorders

Perinatal Brain Injury

Trauma

Cerebrovascular Disease

Infections

Demyelinating Diseases

Neurodegenerative Diseases

Genetic Metabolic Diseases

Toxic and Acquired Metabolic Diseases

Tumors

Acknowledgment

Suggested Readings

 

Chapter 29 The Eye

Orbit

Eyelid

Conjunctiva

Sclera

Cornea

Anterior Segment

Uvea

Retina and Vitreous

Optic Nerve

The End-Stage Eye: Phthisis Bulbi

Suggested Readings

Index

 

An aparitie	30 Jun. 2020
Autor	Vinay Kumar MBBS MD FRCPath (Author), Abul K. Abbas MBBS (Author), Jon C. Aster MD PhD
Dimensiuni	22.23 x 4.45 x 27.94 cm
Editura	Elsevier
Format	Hardcover
ISBN	9780323531139
Limba	Engleza
Nr pag	1392